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'Studies in rodents have shown that male sexual function can be disrupted by fetal or neonatal administration of compounds that alter endocrine homeostasis, such as the synthetic nonsteroidal estrogen diethylstilbestrol [...]

According to recent research published in the journal Behavioral Neuroscience, 'Genetic variation of the serotonin transporter (SCL6A4, 5-HTT) has been associated with fear- and anxiety-related behaviors. while a polymorphism in [...]

Bionovo, Inc. (NASDAQ:BNVI) announced results describing predictable estrogen regulatory elements that can be used to identify estrogenic drugs that are safer. The data, published in Molecular and Cellular Endocrinology, showed [...]

California, USA-based Bionovo has announced results describing predictable estrogen regulatory elements that can be used to identify estrogenic drugs that are safer. The data, published in Molecular and Cellular Endocrinology, [...]

The brain's serotonergic system plays an important role in alcohol preference and consumption. New findings show that specific DNA sequence variations of the serotonin transporter gene can influence drinking intensity [...]

Metaplastic breast cancers with select gene profiles may respond to tyrosine kinase inhibitors. 'Metaplastic breast carcinomas are reported to harbour epidermal growth factor receptor (EGFR) overexpression in up to 80% [...]

Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility. 'Autism is a pervasive developmental disorder affecting more males than females. Heritability estimates for autism can rise above [...]

Protein tyrosine phosphatase nonreceptor type 22 gene 1858T variant is rare in Asian Indians. 'Recently, a gain of function variant C1858T of the lymphoid-specific protein tyrosine phosphatase nonreceptor (LYP, PTPN22) [...]

According to recent research from the United States published in the journal Biological Psychiatry, the serotonin transporter (5-HTT) gene SLC6A4 is not associated with autism. '5-HTT has long been considered [...]

Fms-like tyrosine kinase 3/ITD is a relevant marker for acute myeloid leukemia prognosis. According to recent research from the Netherlands, 'In acute myeloid leukemia (AML), activating mutations in the fms-like [...]

According to research from the People's Republic of China, dopamine system genes are associated with attention deficit hyperactivity disorder (ADHD). 'Molecular genetic investigations of ADHD have found associations with a [...]

According to recent research from the People's Republic of China, estrogen receptor (ER) alpha polymorphisms are associated with susceptibility to hepatocellular carcinoma (HCC) in hepatitis B virus carriers. 'Overexpression of [...]

According to recently published research from South Korea, serotonin transporter protein polymorphism is influential in migraine without aura (MWOA). J.W. Park and colleagues, Catholic University Korea, wrote that the study [...]

Estradiol and TPA exert their effects on TFF1 gene expression by different mechanisms. According to recent research from Canada, 'Histone H3 phosphorylation is a downstream response to activation of the [...]

Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes. According to recent research published in the journal Diabetologia, 'We analysed the contribution of the [...]

Prostate cancer susceptibility was linked to estrogen receptor beta (ER beta) polymorphism. 'After cloning of the second estrogen receptor, ER beta in 1996, increasing evidence of its importance in prostate [...]

Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts. A recent report from the United States notes, & [...]

Mammographic density may be influenced by estrogen and progesterone receptor polymorphisms. & quot;Postmenopausal hormone therapy increases mammographic density, a strong breast cancer risk factor, but effects vary across women, & [...]

A study from Taiwan has reported that dopamine receptor D1 A-48G polymorphism is associated with methamphetamine abuse. 'Several lines of evidence have suggested that substance abuse is mediated by the [...]

Nurr1 and Pitx3 cooperatively promote terminal maturation to the midbrain dopamine neuron phenotype. According to recent research published in the journal Proceedings of the National Academy of Sciences of the [...]

Protein tyrosine phosphatase-N1 polymorphisms are linked to coronary calcified plaque in the Diabetes Heart Study. 'Individuals with type 2 diabetes are at increased risk of cardiovascular disease (CVD) mortality and [...]

Estrogen receptor-alpha gene polymorphism may be associated with left ventricular mass. A recent study from Israel notes, 'The development of left ventricular hypertrophy (LVH) is influenced by gender and by [...]

According to research from the People's Republic of China, no association exists between VNTR polymorphisms of dopamine transporter (DAT) gene and attention deficit hyperactivity disorder (ADHD) in Chinese children. 'DAT [...]

According to research from Italy, a functional serotonin (5HT) transporter (5HTT) gene polymorphism is associated with binge eating disorder (BED). 'The pathophysiological mechanisms underlying BED are poorly understood. There is [...]

The estrogen receptor-beta gene in women is associated with an increased risk of colorectal cancer. According to a report from the United States, 'Estrogen and androgens are thought to be [...]

The therapeutic value of selective estrogen receptor modulators in breast cancer were recently reviewed in Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 'Despite the beneficial effects of estrogens [...]

According to recently published research from England, serotonin transporter gene polymorphisms influence cognitive decline and abilities in the nondemented elderly. 'Dysfunction of the serotonergic pathway disrupts normal cognitive functioning and [...]

For the more than 18 million Americans who suffer from depressive illnesses, the best pharmacological treatments are those that increase levels of serotonin, the brain chemical that regulates mood, sleep, [...]

Shp2 tyrosine phosphatase overexpression was implicated in the leukemogenesis in adult human leukemia. According to a study from the People's Republic of China, 'Shp2 tyrosine phosphatase plays a critical role [...]

Hypertension and estrogen receptor polymorphisms are linked to left ventricular hypertrophy. 'Left ventricular (LV) hypertrophy is a significant risk factor for cardiovascular disease. Given sex-based differences in cardiac structure and [...]

A report from the United States has summarized a family-based association study of dopamine transporter gene (DAT1) and dopamine receptor D4 gene (DRD4) polymorphism in Korean children with Attention Deficit [...]

The presence of the PvuII polymorphism in the estrogen receptor-alpha increases breast cancer risk in postmenopausal women. In a recent study from the Netherlands, scientists 'aimed to investigate whether the [...]

According to recent research from Wales, dopamine transporter (DAT1) gene is not associated with and Attention Deficit Hyperactivity Disorder (ADHD). 'Several groups have reported an association between the 10-repeat allele [...]

According to recent research published in the journal Mechanisms of Ageing and Development, a long-allele genotype of the serotonin transporter (5HTT)-linked gene is prevalent in centenarians. 'Negative affect such as [...]

ERTargetDB (http://bioinformatics.med.ohio-state.edu/ERTargetDB/index.jsp) is a valuable resource for information on estrogen receptor (ER) target gene regulation. ER 'plays an important role in several physiologic functions of both the reproductive and nonreproductive [...]

In Chinese families the estrogen receptor alpha gene is not linked to bone mineral density or body mass index. 'Estrogen receptor alpha (ER-alpha) plays an important role in mediating estrogen [...]

A role in breast cancer risk was not seen with certain estrogen metabolizing polymorphisms in older white women. Scientists in the United States conducted a study 'to investigate breast cancer [...]

The occurrence of EGFR tyrosine kinase domain mutations can be used to predict the pathogenesis of lung cancer. In a recent article published in the journal Cancer Research, scientists in [...]

Dopamine transporter (DAT) genotype influences the response to methylphenidate treatment in children with attention deficit hyperactivity disorder (ADHD). 'Stimulant medications, such as methylphenidate (MPH), are the most commonly used, effective [...]

Serotonin gene polymorphisms do not interact in schizophrenia. According to new research from South Korea, 'this study was to aim at investigating the potential interaction for the serotonin receptor gene [...]

Testing of 7,883 people did not reveal any significant association between the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes. 'Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 [...]

Testing of 7,883 people did not reveal any significant association between the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes. 'Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 [...]

Testing of 7,883 people did not reveal any significant association between the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes. 'Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 [...]

Testing of 7,883 people did not reveal any significant association between the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes. 'Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 [...]

Testing of 7,883 people did not reveal any significant association between the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes. 'Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 [...]

Testing of 7,883 people did not reveal any significant association between the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes. 'Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 [...]

Testing of 7,883 people did not reveal any significant association between the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes. 'Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 [...]

Testing of 7,883 people did not reveal any significant association between the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes. 'Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 [...]

According to recent research from France published in the journal Human Molecular Genetics, activating mutations of the tyrosine kinase receptor fibroblast growth factor receptor 3 (FGFR3) are associated with benign [...]