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2. Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis

Author

Wannan, Cassandra M J, primary, Nelson, Barnaby, additional, Addington, Jean, additional, Allott, Kelly, additional, Anticevic, Alan, additional, Arango, Celso, additional, Baker, Justin T, additional, Bearden, Carrie E, additional, Billah, Tashrif, additional, Bouix, Sylvain, additional, Broome, Matthew R, additional, Buccilli, Kate, additional, Cadenhead, Kristin S, additional, Calkins, Monica E, additional, Cannon, Tyrone D, additional, Cecci, Guillermo, additional, Chen, Eric Yu Hai, additional, Cho, Kang Ik K, additional, Choi, Jimmy, additional, Clark, Scott R, additional, Coleman, Michael J, additional, Conus, Philippe, additional, Corcoran, Cheryl M, additional, Cornblatt, Barbara A, additional, Diaz-Caneja, Covadonga M, additional, Dwyer, Dominic, additional, Ebdrup, Bjørn H, additional, Ellman, Lauren M, additional, Fusar-Poli, Paolo, additional, Galindo, Liliana, additional, Gaspar, Pablo A, additional, Gerber, Carla, additional, Glenthøj, Louise Birkedal, additional, Glynn, Robert, additional, Harms, Michael P, additional, Horton, Leslie E, additional, Kahn, René S, additional, Kambeitz, Joseph, additional, Kambeitz-Ilankovic, Lana, additional, Kane, John M, additional, Kapur, Tina, additional, Keshavan, Matcheri S, additional, Kim, Sung-Wan, additional, Koutsouleris, Nikolaos, additional, Kubicki, Marek, additional, Kwon, Jun Soo, additional, Langbein, Kerstin, additional, Lewandowski, Kathryn E, additional, Light, Gregory A, additional, Mamah, Daniel, additional, Marcy, Patricia J, additional, Mathalon, Daniel H, additional, McGorry, Patrick D, additional, Mittal, Vijay A, additional, Nordentoft, Merete, additional, Nunez, Angela, additional, Pasternak, Ofer, additional, Pearlson, Godfrey D, additional, Perez, Jesus, additional, Perkins, Diana O, additional, Powers, Albert R, additional, Roalf, David R, additional, Sabb, Fred W, additional, Schiffman, Jason, additional, Shah, Jai L, additional, Smesny, Stefan, additional, Spark, Jessica, additional, Stone, William S, additional, Strauss, Gregory P, additional, Tamayo, Zailyn, additional, Torous, John, additional, Upthegrove, Rachel, additional, Vangel, Mark, additional, Verma, Swapna, additional, Wang, Jijun, additional, Rossum, Inge Winter-van, additional, Wolf, Daniel H, additional, Wolff, Phillip, additional, Wood, Stephen J, additional, Yung, Alison R, additional, Agurto, Carla, additional, Alvarez-Jimenez, Mario, additional, Amminger, Paul, additional, Armando, Marco, additional, Asgari-Targhi, Ameneh, additional, Cahill, John, additional, Carrión, Ricardo E, additional, Castro, Eduardo, additional, Cetin-Karayumak, Suheyla, additional, Mallar Chakravarty, M, additional, Cho, Youngsun T, additional, Cotter, David, additional, D’Alfonso, Simon, additional, Ennis, Michaela, additional, Fadnavis, Shreyas, additional, Fonteneau, Clara, additional, Gao, Caroline, additional, Gupta, Tina, additional, Gur, Raquel E, additional, Gur, Ruben C, additional, Hamilton, Holly K, additional, Hoftman, Gil D, additional, Jacobs, Grace R, additional, Jarcho, Johanna, additional, Ji, Jie Lisa, additional, Kohler, Christian G, additional, Lalousis, Paris Alexandros, additional, Lavoie, Suzie, additional, Lepage, Martin, additional, Liebenthal, Einat, additional, Mervis, Josh, additional, Murty, Vishnu, additional, Nicholas, Spero C, additional, Ning, Lipeng, additional, Penzel, Nora, additional, Poldrack, Russell, additional, Polosecki, Pablo, additional, Pratt, Danielle N, additional, Rabin, Rachel, additional, Rahimi Eichi, Habiballah, additional, Rathi, Yogesh, additional, Reichenberg, Avraham, additional, Reinen, Jenna, additional, Rogers, Jack, additional, Ruiz-Yu, Bernalyn, additional, Scott, Isabelle, additional, Seitz-Holland, Johanna, additional, Srihari, Vinod H, additional, Srivastava, Agrima, additional, Thompson, Andrew, additional, Turetsky, Bruce I, additional, Walsh, Barbara C, additional, Whitford, Thomas, additional, Wigman, Johanna T W, additional, Yao, Beier, additional, Yuen, Hok Pan, additional, Ahmed, Uzair, additional, Byun, Andrew (Jin Soo), additional, Chung, Yoonho, additional, Do, Kim, additional, Hendricks, Larry, additional, Huynh, Kevin, additional, Jeffries, Clark, additional, Lane, Erlend, additional, Langholm, Carsten, additional, Lin, Eric, additional, Mantua, Valentina, additional, Santorelli, Gennarina, additional, Ruparel, Kosha, additional, Zoupou, Eirini, additional, Adasme, Tatiana, additional, Addamo, Lauren, additional, Adery, Laura, additional, Ali, Munaza, additional, Auther, Andrea, additional, Aversa, Samantha, additional, Baek, Seon-Hwa, additional, Bates, Kelly, additional, Bathery, Alyssa, additional, Bayer, Johanna M M, additional, Beedham, Rebecca, additional, Bilgrami, Zarina, additional, Birch, Sonia, additional, Bonoldi, Ilaria, additional, Borders, Owen, additional, Borgatti, Renato, additional, Brown, Lisa, additional, Bruna, Alejandro, additional, Carrington, Holly, additional, Castillo-Passi, Rolando I, additional, Chen, Justine, additional, Cheng, Nicholas, additional, Ching, Ann Ee, additional, Clifford, Chloe, additional, Colton, Beau-Luke, additional, Contreras, Pamela, additional, Corral, Sebastián, additional, Damiani, Stefano, additional, Done, Monica, additional, Estradé, Andrés, additional, Etuka, Brandon Asika, additional, Formica, Melanie, additional, Furlan, Rachel, additional, Geljic, Mia, additional, Germano, Carmela, additional, Getachew, Ruth, additional, Goncalves, Mathias, additional, Haidar, Anastasia, additional, Hartmann, Jessica, additional, Jo, Anna, additional, John, Omar, additional, Kerins, Sarah, additional, Kerr, Melissa, additional, Kesselring, Irena, additional, Kim, Honey, additional, Kim, Nicholas, additional, Kinney, Kyle, additional, Krcmar, Marija, additional, Kotler, Elana, additional, Lafanechere, Melanie, additional, Lee, Clarice, additional, Llerena, Joshua, additional, Markiewicz, Christopher, additional, Matnejl, Priya, additional, Maturana, Alejandro, additional, Mavambu, Aissata, additional, Mayol-Troncoso, Rocío, additional, McDonnell, Amelia, additional, McGowan, Alessia, additional, McLaughlin, Danielle, additional, McIlhenny, Rebecca, additional, McQueen, Brittany, additional, Mebrahtu, Yohannes, additional, Mensi, Martina, additional, Hui, Christy Lai Ming, additional, Suen, Yi Nam, additional, Wong, Stephanie Ming Yin, additional, Morrell, Neal, additional, Omar, Mariam, additional, Partridge, Alice, additional, Phassouliotis, Christina, additional, Pichiecchio, Anna, additional, Politi, Pierluigi, additional, Porter, Christian, additional, Provenzani, Umberto, additional, Prunier, Nicholas, additional, Raj, Jasmine, additional, Ray, Susan, additional, Rayner, Victoria, additional, Reyes, Manuel, additional, Reynolds, Kate, additional, Rush, Sage, additional, Salinas, Cesar, additional, Shetty, Jashmina, additional, Snowball, Callum, additional, Tod, Sophie, additional, Turra-Fariña, Gabriel, additional, Valle, Daniela, additional, Veale, Simone, additional, Whitson, Sarah, additional, Wickham, Alana, additional, Youn, Sarah, additional, Zamorano, Francisco, additional, Zavaglia, Elissa, additional, Zinberg, Jamie, additional, Woods, Scott W, additional, and Shenton, Martha E, additional

Published
2024
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3. Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ):Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis

Author

Wannan, Cassandra M.J., Nelson, Barnaby, Addington, Jean, Allott, Kelly, Anticevic, Alan, Arango, Celso, Baker, Justin T., Bearden, Carrie E., Billah, Tashrif, Bouix, Sylvain, Broome, Matthew R., Buccilli, Kate, Cadenhead, Kristin S., Calkins, Monica E., Cannon, Tyrone D., Cecci, Guillermo, Chen, Eric Yu Hai, Cho, Kang Ik K., Choi, Jimmy, Clark, Scott R., Coleman, Michael J., Conus, Philippe, Corcoran, Cheryl M., Cornblatt, Barbara A., Diaz-Caneja, Covadonga M., Dwyer, Dominic, Ebdrup, Bjørn H., Ellman, Lauren M., Fusar-Poli, Paolo, Galindo, Liliana, Gaspar, Pablo A., Gerber, Carla, Glenthøj, Louise Birkedal, Glynn, Robert, Harms, Michael P., Horton, Leslie E., Kahn, René S., Kambeitz, Joseph, Kambeitz-Ilankovic, Lana, Kane, John M., Kapur, Tina, Keshavan, Matcheri S., Kim, Sung Wan, Koutsouleris, Nikolaos, Kubicki, Marek, Kwon, Jun Soo, Langbein, Kerstin, Lewandowski, Kathryn E., Light, Gregory A., Mamah, Daniel, Marcy, Patricia J., Mathalon, Daniel H., McGorry, Patrick D., Mittal, Vijay A., Nordentoft, Merete, Nunez, Angela, Pasternak, Ofer, Pearlson, Godfrey D., Perez, Jesus, Perkins, Diana O., Powers, Albert R., Roalf, David R., Sabb, Fred W., Schiffman, Jason, Shah, Jai L., Smesny, Stefan, Spark, Jessica, Stone, William S., Strauss, Gregory P., Tamayo, Zailyn, Torous, John, Upthegrove, Rachel, Vangel, Mark, Verma, Swapna, Wang, Jijun, Rossum, Inge Winter van, Wolf, Daniel H., Wolff, Phillip, Wood, Stephen J., Yung, Alison R., Agurto, Carla, Alvarez-Jimenez, Mario, Amminger, Paul, Armando, Marco, Asgari-Targhi, Ameneh, Cahill, John, Carrión, Ricardo E., Castro, Eduardo, Cetin-Karayumak, Suheyla, Mallar Chakravarty, M., Cho, Youngsun T., Cotter, David, D'Alfonso, Simon, Ennis, Michaela, Fadnavis, Shreyas, Fonteneau, Clara, Gao, Caroline, Gupta, Tina, Gur, Raquel E., Gur, Ruben C., Hamilton, Holly K., Hoftman, Gil D., Jacobs, Grace R., Jarcho, Johanna, Ji, Jie Lisa, Kohler, Christian G., Lalousis, Paris Alexandros, Lavoie, Suzie, Lepage, Martin, Liebenthal, Einat, Mervis, Josh, Murty, Vishnu, Nicholas, Spero C., Ning, Lipeng, Penzel, Nora, Poldrack, Russell, Polosecki, Pablo, Pratt, Danielle N., Rabin, Rachel, Rahimi Eichi, Habiballah, Rathi, Yogesh, Reichenberg, Avraham, Reinen, Jenna, Rogers, Jack, Ruiz-Yu, Bernalyn, Scott, Isabelle, Seitz-Holland, Johanna, Srihari, Vinod H., Srivastava, Agrima, Thompson, Andrew, Turetsky, Bruce I., Walsh, Barbara C., Whitford, Thomas, Wigman, Johanna T.W., Yao, Beier, Yuen, Hok Pan, Ahmed, Uzair, Byun, Andrew Jin Soo, Chung, Yoonho, Do, Kim, Hendricks, Larry, Huynh, Kevin, Jeffries, Clark, Lane, Erlend, Langholm, Carsten, Lin, Eric, Mantua, Valentina, Santorelli, Gennarina, Ruparel, Kosha, Zoupou, Eirini, Adasme, Tatiana, Addamo, Lauren, Adery, Laura, Ali, Munaza, Auther, Andrea, Aversa, Samantha, Baek, Seon Hwa, Bates, Kelly, Bathery, Alyssa, Bayer, Johanna M.M., Beedham, Rebecca, Bilgrami, Zarina, Birch, Sonia, Bonoldi, Ilaria, Borders, Owen, Borgatti, Renato, Brown, Lisa, Bruna, Alejandro, Carrington, Holly, Castillo-Passi, Rolando I., Chen, Justine, Cheng, Nicholas, Ching, Ann Ee, Clifford, Chloe, Colton, Beau Luke, Contreras, Pamela, Corral, Sebastián, Damiani, Stefano, Done, Monica, Estradé, Andrés, Etuka, Brandon Asika, Formica, Melanie, Furlan, Rachel, Geljic, Mia, Germano, Carmela, Getachew, Ruth, Goncalves, Mathias, Haidar, Anastasia, Hartmann, Jessica, Jo, Anna, John, Omar, Kerins, Sarah, Kerr, Melissa, Kesselring, Irena, Kim, Honey, Kim, Nicholas, Kinney, Kyle, Krcmar, Marija, Kotler, Elana, Lafanechere, Melanie, Lee, Clarice, Llerena, Joshua, Markiewicz, Christopher, Matnejl, Priya, Maturana, Alejandro, Mavambu, Aissata, Mayol-Troncoso, Rocío, McDonnell, Amelia, McGowan, Alessia, McLaughlin, Danielle, McIlhenny, Rebecca, McQueen, Brittany, Mebrahtu, Yohannes, Mensi, Martina, Hui, Christy Lai Ming, Suen, Yi Nam, Wong, Stephanie Ming Yin, Morrell, Neal, Omar, Mariam, Partridge, Alice, Phassouliotis, Christina, Pichiecchio, Anna, Politi, Pierluigi, Porter, Christian, Provenzani, Umberto, Prunier, Nicholas, Raj, Jasmine, Ray, Susan, Rayner, Victoria, Reyes, Manuel, Reynolds, Kate, Rush, Sage, Salinas, Cesar, Shetty, Jashmina, Snowball, Callum, Tod, Sophie, Turra-Fariña, Gabriel, Valle, Daniela, Veale, Simone, Whitson, Sarah, Wickham, Alana, Youn, Sarah, Zamorano, Francisco, Zavaglia, Elissa, Zinberg, Jamie, Woods, Scott W., Shenton, Martha E., Wannan, Cassandra M.J., Nelson, Barnaby, Addington, Jean, Allott, Kelly, Anticevic, Alan, Arango, Celso, Baker, Justin T., Bearden, Carrie E., Billah, Tashrif, Bouix, Sylvain, Broome, Matthew R., Buccilli, Kate, Cadenhead, Kristin S., Calkins, Monica E., Cannon, Tyrone D., Cecci, Guillermo, Chen, Eric Yu Hai, Cho, Kang Ik K., Choi, Jimmy, Clark, Scott R., Coleman, Michael J., Conus, Philippe, Corcoran, Cheryl M., Cornblatt, Barbara A., Diaz-Caneja, Covadonga M., Dwyer, Dominic, Ebdrup, Bjørn H., Ellman, Lauren M., Fusar-Poli, Paolo, Galindo, Liliana, Gaspar, Pablo A., Gerber, Carla, Glenthøj, Louise Birkedal, Glynn, Robert, Harms, Michael P., Horton, Leslie E., Kahn, René S., Kambeitz, Joseph, Kambeitz-Ilankovic, Lana, Kane, John M., Kapur, Tina, Keshavan, Matcheri S., Kim, Sung Wan, Koutsouleris, Nikolaos, Kubicki, Marek, Kwon, Jun Soo, Langbein, Kerstin, Lewandowski, Kathryn E., Light, Gregory A., Mamah, Daniel, Marcy, Patricia J., Mathalon, Daniel H., McGorry, Patrick D., Mittal, Vijay A., Nordentoft, Merete, Nunez, Angela, Pasternak, Ofer, Pearlson, Godfrey D., Perez, Jesus, Perkins, Diana O., Powers, Albert R., Roalf, David R., Sabb, Fred W., Schiffman, Jason, Shah, Jai L., Smesny, Stefan, Spark, Jessica, Stone, William S., Strauss, Gregory P., Tamayo, Zailyn, Torous, John, Upthegrove, Rachel, Vangel, Mark, Verma, Swapna, Wang, Jijun, Rossum, Inge Winter van, Wolf, Daniel H., Wolff, Phillip, Wood, Stephen J., Yung, Alison R., Agurto, Carla, Alvarez-Jimenez, Mario, Amminger, Paul, Armando, Marco, Asgari-Targhi, Ameneh, Cahill, John, Carrión, Ricardo E., Castro, Eduardo, Cetin-Karayumak, Suheyla, Mallar Chakravarty, M., Cho, Youngsun T., Cotter, David, D'Alfonso, Simon, Ennis, Michaela, Fadnavis, Shreyas, Fonteneau, Clara, Gao, Caroline, Gupta, Tina, Gur, Raquel E., Gur, Ruben C., Hamilton, Holly K., Hoftman, Gil D., Jacobs, Grace R., Jarcho, Johanna, Ji, Jie Lisa, Kohler, Christian G., Lalousis, Paris Alexandros, Lavoie, Suzie, Lepage, Martin, Liebenthal, Einat, Mervis, Josh, Murty, Vishnu, Nicholas, Spero C., Ning, Lipeng, Penzel, Nora, Poldrack, Russell, Polosecki, Pablo, Pratt, Danielle N., Rabin, Rachel, Rahimi Eichi, Habiballah, Rathi, Yogesh, Reichenberg, Avraham, Reinen, Jenna, Rogers, Jack, Ruiz-Yu, Bernalyn, Scott, Isabelle, Seitz-Holland, Johanna, Srihari, Vinod H., Srivastava, Agrima, Thompson, Andrew, Turetsky, Bruce I., Walsh, Barbara C., Whitford, Thomas, Wigman, Johanna T.W., Yao, Beier, Yuen, Hok Pan, Ahmed, Uzair, Byun, Andrew Jin Soo, Chung, Yoonho, Do, Kim, Hendricks, Larry, Huynh, Kevin, Jeffries, Clark, Lane, Erlend, Langholm, Carsten, Lin, Eric, Mantua, Valentina, Santorelli, Gennarina, Ruparel, Kosha, Zoupou, Eirini, Adasme, Tatiana, Addamo, Lauren, Adery, Laura, Ali, Munaza, Auther, Andrea, Aversa, Samantha, Baek, Seon Hwa, Bates, Kelly, Bathery, Alyssa, Bayer, Johanna M.M., Beedham, Rebecca, Bilgrami, Zarina, Birch, Sonia, Bonoldi, Ilaria, Borders, Owen, Borgatti, Renato, Brown, Lisa, Bruna, Alejandro, Carrington, Holly, Castillo-Passi, Rolando I., Chen, Justine, Cheng, Nicholas, Ching, Ann Ee, Clifford, Chloe, Colton, Beau Luke, Contreras, Pamela, Corral, Sebastián, Damiani, Stefano, Done, Monica, Estradé, Andrés, Etuka, Brandon Asika, Formica, Melanie, Furlan, Rachel, Geljic, Mia, Germano, Carmela, Getachew, Ruth, Goncalves, Mathias, Haidar, Anastasia, Hartmann, Jessica, Jo, Anna, John, Omar, Kerins, Sarah, Kerr, Melissa, Kesselring, Irena, Kim, Honey, Kim, Nicholas, Kinney, Kyle, Krcmar, Marija, Kotler, Elana, Lafanechere, Melanie, Lee, Clarice, Llerena, Joshua, Markiewicz, Christopher, Matnejl, Priya, Maturana, Alejandro, Mavambu, Aissata, Mayol-Troncoso, Rocío, McDonnell, Amelia, McGowan, Alessia, McLaughlin, Danielle, McIlhenny, Rebecca, McQueen, Brittany, Mebrahtu, Yohannes, Mensi, Martina, Hui, Christy Lai Ming, Suen, Yi Nam, Wong, Stephanie Ming Yin, Morrell, Neal, Omar, Mariam, Partridge, Alice, Phassouliotis, Christina, Pichiecchio, Anna, Politi, Pierluigi, Porter, Christian, Provenzani, Umberto, Prunier, Nicholas, Raj, Jasmine, Ray, Susan, Rayner, Victoria, Reyes, Manuel, Reynolds, Kate, Rush, Sage, Salinas, Cesar, Shetty, Jashmina, Snowball, Callum, Tod, Sophie, Turra-Fariña, Gabriel, Valle, Daniela, Veale, Simone, Whitson, Sarah, Wickham, Alana, Youn, Sarah, Zamorano, Francisco, Zavaglia, Elissa, Zinberg, Jamie, Woods, Scott W., and Shenton, Martha E.

Abstract

This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals., This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.

Published
2024

8. Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS

Author

Woods, Scott W., Parker, Sophie, Kerr, Melissa J., Walsh, Barbara C., Wijtenburg, S. Andrea, Prunier, Nicholas, Nunez, Angela R., Buccilli, Kate, Mourgues-Codern, Catalina, Brummitt, Kali, Kinney, Kyle S., Trankler, Carli, Szacilo, Julia, Colton, Beau-Luke, Ali, Munaza, Haidar, Anastasia, Billah, Tashrif, Huynh, Kevin, Ahmed, Uzair, Adery, Laura L., Corcoran, Cheryl M., Perkins, Diana O., Schiffman, Jason, Perez, Jesus, Mamah, Daniel, Ellman, Lauren M., Powers, Albert R., Coleman, Michael J., Anticevic, Alan, Fusar-Poli, Paolo, Kane, John M., Kahn, Rene S., McGorry, Patrick D., Bearden, Carrie E., Shenton, Martha E., Nelson, Barnaby, Calkins, Monica E., Hendricks, Larry, Bouix, Sylvain, Addington, Jean, McGlashan, Thomas H., Yung, Alison R., Allott, Kelly, Clark, Scott R., Kapur, Tina, Lavoie, S., Lewandowski, Kathryn E., Mathalon, Daniel H., Pasternak, Ofer, Stone, William S., Torous, John, Rowland, Laura M., Zhan, Ming, Amminger, Paul, Arango, Celso, Broome, Matthew R., Cadenhead, Kristin S., Chen, Eric Y.H., Choi, Jimmy, Kevin Cho, Kang Ik, Conus, Philippe, Cornblatt, Barbara A., Glenthøj, Louise Birkedal, Horton, Leslie E., Kambeitz, Joseph, Keshavan, Matcheri S., Koutsouleris, Nikolaos, Langbein, Kerstin, Diaz-Caneja, Covadonga Martinez, Mittal, Vijay A., Nordentoft, Merete, Gaspar Ramos, Pablo A., Pearlson, Godfrey D., Shah, Jai L., Smesny, Stefan, Strauss, Gregory P., Wang, Jijun, Marcy, Patricia J., Matneja, Priya, Phassouliotis, Christina, Ray, Susan, Snowball, Collum, Spark, Jessica, and Tod, Sophie

Subjects
Article
Abstract

AIM: To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR-P): the Structured Interview for Psychosis-risk Syndromes (SIPS) and the Comprehensive Assessment of At-Risk Mental States (CAARMS). METHODS: The initial workshop is described in the companion report from Addington et al. After the workshop, lead experts for each instrument continued harmonizing attenuated positive symptoms and criteria for psychosis and CHR-P through an intensive series of joint videoconferences. RESULTS: Full harmonization was achieved for attenuated positive symptom ratings and psychosis criteria, and partial harmonization for CHR-P criteria. The semi-structured interview, named P ositive SY mptoms and Diagnostic Criteria for the C AARMS H armonized with the S IPS (PSYCHS), generates CHR-P criteria and severity scores for both CAARMS and SIPS. CONCLUSION: Using the PSYCHS for CHR-P ascertainment, conversion determination, and attenuated positive symptom severity rating will help in comparing findings across studies and in meta-analyses.

Published
2023

14. Stress hormones and verbal memory in young people over the first 12 weeks of treatment for psychosis

Author

Allott, Kelly, Yuen, Hok Pan, Bartholomeusz, Cali, Rapado-Castro, Marta, Phassouliotis, Christina, Butselaar, Felicity, Wood, Stephen, Proffitt, Tina-Marie, Savage, Greg, Phillips, Lisa, Bendall, Sarah, Markulev, Connie, Reniers, Renate, Pantelis, Christos, Baldwin, Lara, McGorry, Patrick, Garner, Belinda, Allott, Kelly, Yuen, Hok Pan, Bartholomeusz, Cali, Rapado-Castro, Marta, Phassouliotis, Christina, Butselaar, Felicity, Wood, Stephen, Proffitt, Tina-Marie, Savage, Greg, Phillips, Lisa, Bendall, Sarah, Markulev, Connie, Reniers, Renate, Pantelis, Christos, Baldwin, Lara, McGorry, Patrick, and Garner, Belinda

Abstract

Aims Memory impairment in psychosis may be mediated through detrimental effects of hypothalamic-pituitary-adrenal (HPA) axis function. This study prospectively investigated the relationship between cortisol, sulphate dehydroepiandrosterone (DHEA(S) and cortisol: DHEA(S) ratio and memory in 35 first-episode psychosis (FEP) patients during the first 12 weeks of treatment and 23 healthy controls (HC). Methods Morning blood sampling and tests of attention, working memory and verbal memory occurred at baseline and 12-week follow-up. Results FEP and HC groups did not significantly differ in levels of cortisol, DHEA(S) or their ratio at baseline or over 12-weeks. The FEP group performed significantly below HC on all cognitive measures at baseline and over 12-weeks. Cortisol levels were unrelated to cognition in both groups. At baseline, DHEA(S) was positively associated with attention in HCs, but negatively associated with attention in FEP participants. Change in DHEA(S) was negatively associated with change in memory over 12-weeks in both groups. At 12-weeks, there was a negative correlation between the cortisol: DHEA(S) ratio and attention in both groups. Conclusions These findings are mostly in contrast to findings in chronic schizophrenia. Investigation at different illness phases and over longer-follow-up periods is required to determine the complex relationship between HPA-axis and memory functioning in psychosis.

Published
2018

16. Stability of retrospective self‐reports of childhood trauma in first‐episode psychosis.

Author

Simpson, Samantha, Phillips, Lisa, Baksheev, Gennady, Garner, Belinda, Markulev, Connie, Phassouliotis, Christina, Alvarez‐Jimenez, Mario, McGorry, Patrick, and Bendall, Sarah

Subjects
PSYCHOSES, CHILDREN, YOUTH, DELUSIONS, STATISTICAL correlation
Abstract

Aim: Childhood trauma (CT), abuse and neglect are commonly reported by individuals experiencing psychosis. However, there are concerns that acute psychotic symptoms, in particular delusions, may contribute to inaccurate reporting of CT. As a result, individuals experiencing psychosis may not be asked about their experiences of abuse when they are being seen in psychiatric settings. This lack of attention can directly impact on the tailoring of their clinical care. This study aimed to investigate the stability of reports of CT by young people experiencing a first psychotic episode (FEP) compared to healthy comparison subjects. Methods: Responses of 24 young people during the acute FEP and 3 months later to items on the Childhood Trauma Questionnaire (CTQ) were compared to 30 non‐psychiatric controls. All participants were aged 15 to 25 years. Results: FEP participants reported higher CT than controls at both time points. Reliability analyses (interclass correlation coefficients [ICCs]) suggested strong agreement between CT reports at baseline and follow‐up for FEP participants (.81) and controls (.91). Positive psychotic symptoms were unrelated to CT reports. Although the severity of CT reports fluctuated between assessments, complete retractions of severe abuse claims occurred rarely. Conclusions: The results suggest that retrospective self‐report can be used to reliably assess CT in young people experiencing acute psychosis. [ABSTRACT FROM AUTHOR]

Published
2019
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17. Adjunctive Taurine in First-Episode Psychosis

Author

O’Donnell, Colin P., primary, Allott, Kelly A., additional, Murphy, Brendan P., additional, Yuen, Hok Pan, additional, Proffitt, Tina-Marie, additional, Papas, Alicia, additional, Moral, Jennifer, additional, Pham, Tee, additional, O’Regan, Michaela K., additional, Phassouliotis, Christina, additional, Simpson, Raelene, additional, and McGorry, Patrick D., additional

Published
2016
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18. Does co‐occurring borderline personality disorder influence acute phase treatment for first‐episode psychosis?

Author

Francey, Shona M., Jovev, Martina, Phassouliotis, Christina, Cotton, Sue M., and Chanen, Andrew M.

Subjects
BORDERLINE personality disorder, PSYCHOSES, COMORBIDITY, SUICIDE, GUIDELINES
Abstract

Background: This aims of this study were: (1) to determine the prevalence of co‐occurring borderline personality disorder (BPD) in a first‐episode psychosis (FEP) sample; (2) to determine differences between patients with and without BPD on demographics, comorbidities and clinical risks and other variables; and (3) to examine whether BPD comorbidity influenced treatment received by patients for FEP during their first 3 months after service entry to a specialist early psychosis service. Methods: A file audit was conducted for 100 consecutive admissions to an early psychosis service. Patients with a clinician‐rated co‐occurring diagnosis of BPD were compared with patients without clinician‐rated BPD on a range of variables. Results: Twenty‐two percent of the FEP sample was diagnosed with co‐occurring BPD by clinician ratings. The FEP group with co‐occurring BPD was found to be younger, more likely to have other comorbidities, and were at higher risk of suicide and violent behaviour. Group differences were found in treatment received for FEP, whereby patients with co‐occurring BPD had poorer access to standard treatment, including guideline concordant antipsychotic medication prescription. Conclusion: Young people with co‐occurring clinician‐rated BPD and FEP experienced greater difficulty accessing standard care for FEP and received relatively different treatment, including different pharmacotherapy, compared with those FEP patients without BPD. There is a need to develop new clinical guidelines and effective treatments for this specific subgroup with early psychosis and co‐occurring BPD that take into account interpersonal and "premorbid" aspects of their presenting problems. [ABSTRACT FROM AUTHOR]

Published
2018
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19. The impact of neuropsychological functioning and coping style on perceived stress in individuals with first-episode psychosis and healthy controls

Author

Allott, Kelly, Rapado-Castro, Marta, Proffitt, Tina-Marie, Bendall, Sarah, Garner, Belinda, Butselaar, Felicity, Markulev, Connie, Phassouliotis, Christina, McGorry, Patrick, Wood, Stephen, Cotton, Sue, Phillips, Lisa, Allott, Kelly, Rapado-Castro, Marta, Proffitt, Tina-Marie, Bendall, Sarah, Garner, Belinda, Butselaar, Felicity, Markulev, Connie, Phassouliotis, Christina, McGorry, Patrick, Wood, Stephen, Cotton, Sue, and Phillips, Lisa

Abstract

Stress is implicated in the development and course of psychotic illness, but the factors that influence stress levels are not well understood. The aim of this study was to examine the impact of neuropsychological functioning and coping styles on perceived stress in people with first-episode psychosis (FEP) and healthy controls (HC). Thirty-four minimally treated FEP patients from the Early Psychosis Prevention and Intervention Centre, Melbourne, Australia, and 26 HC participants from a similar demographic area participated in the study. Participants completed a comprehensive neuropsychological test battery as well as the Coping Inventory for Stressful Situations (task-, emotion- and avoidance-focussed coping styles) and Perceived Stress Scale (PSS). Linear regressions were used to determine the contribution of neuropsychological functioning and coping style to perceived stress in the two groups. In the FEP group, higher levels of emotion-focussed and lower levels of task-focussed coping were associated with elevated stress. Higher premorbid IQ and working memory were also associated with higher subjective stress. In the HC group, higher levels of emotion-focussed coping, and contrary to the FEP group, lower premorbid IQ, working memory and executive functioning, were associated with increased stress. Lower intellectual functioning may provide some protection against perceived stress in FEP.

Published
2015

20. The relationship between stress, HPA axis functioning and brain structure in first episode psychosis over the first 12 weeks of treatment

Author

Reniers, Renate, Garner, Belinda, Phassouliotis, Christina, Phillips, Lisa, Markulev, Connie, Pantelis, Christof, Bendall, Sarah, McGorry, Patrick, Wood, Stephen, Reniers, Renate, Garner, Belinda, Phassouliotis, Christina, Phillips, Lisa, Markulev, Connie, Pantelis, Christof, Bendall, Sarah, McGorry, Patrick, and Wood, Stephen

Abstract

Stress and abnormal hypothalamic-pituitary-adrenal axis functioning have been implicated in the early phase of psychosis and may partly explain reported changes in brain structure. This study used magnetic resonance imaging to investigate whether biological measures of stress were related to brain structure at baseline and to structural changes over the first 12 weeks of treatment in first episode patients (n=22) compared with matched healthy controls (n=22). At baseline, no significant group differences in biological measures of stress, cortical thickness or hippocampal volume were observed, but a significantly stronger relationship between baseline levels of cortisol and smaller white matter volumes of the cuneus and anterior cingulate was found in patients compared with controls. Over the first 12 weeks of treatment, patients showed a significant reduction in thickness of the posterior cingulate compared with controls. Patients also showed a significant positive relationship between baseline cortisol and increases in hippocampal volume over time, suggestive of brain swelling in association with psychotic exacerbation, while no such relationship was observed in controls. The current findings provide some support for the involvement of stress mechanisms in the pathophysiology of early psychosis, but the changes are subtle and warrant further investigation.

Published
2015

23. Relationship between vocational status and perceived stress and daily hassles in first-episode psychosis: an exploratory study

Author

Allott, Kelly, Yuen, Hok Pan, Garner, Belinda, Bendall, Sarah, Killackey, Eoin, Alvarez-Jimenez, Mario, Phassouliotis, Christina, Markulev, Connie, Yun, Yang, McGorry, Patrick, Phillips, Lisa, Allott, Kelly, Yuen, Hok Pan, Garner, Belinda, Bendall, Sarah, Killackey, Eoin, Alvarez-Jimenez, Mario, Phassouliotis, Christina, Markulev, Connie, Yun, Yang, McGorry, Patrick, and Phillips, Lisa

Abstract

PURPOSE Vocational recovery is a primary treatment goal of young people with first-episode psychosis (FEP), yet treatment in this domain is often delayed due to concerns that it might be too stressful. This study aimed to examine whether a relationship exists between vocational status and level of perceived stress and daily hassles in FEP. METHODS Forty-seven FEP participants were recruited upon admission to the Early Psychosis Prevention and Intervention Centre (EPPIC), Melbourne. Demographics, psychopathology, perceived stress (Perceived Stress Scale; PSS) and daily hassles (Hassles Scale; HS) were measured. RESULTS Regarding vocational status, 19 participants were unemployed, 13 were employed, 14 were students, and 1 reported 'home duties'. ANOVAs and post hoc tests comparing the first three groups on perceived stress and daily hassles revealed that the mean PSS Total and mean PSS Distress scores of the employed group were significantly lower than those of the unemployed and student groups. Regarding hassles scores, the employed group had a significantly lower mean Hassles Intensity score than the unemployed group. Results were largely unchanged when covariates were included. There were no significant differences between the three groups in levels of anxiety, negative or positive symptoms. The employed group reported lower depression than the student group, but this finding disappeared after controlling for gender. CONCLUSIONS These results provide preliminary evidence supporting the notion that working or studying is not associated with increased perceived stress or daily hassles in FEP. The findings require replication in larger samples and in different phases of psychosis.

Published
2013

24. Relationship between vocational status and perceived stress and daily hassles in first-episode psychosis: an exploratory study

Author

Allott, Kelly A., primary, Yuen, Hok Pan, additional, Garner, Belinda, additional, Bendall, Sarah, additional, Killackey, Eoin J., additional, Alvarez-Jimenez, Mario, additional, Phassouliotis, Christina, additional, Markulev, Connie, additional, Yun, Yang, additional, McGorry, Patrick D., additional, and Phillips, Lisa J., additional

Published
2012
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27. Adjunctive Taurine in First-Episode Psychosis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study.

Author

O'Donnell CP, Allott KA, Murphy BP, Yuen HP, Proffitt TM, Papas A, Moral J, Pham T, O'Regan MK, Phassouliotis C, Simpson R, and McGorry PD

Subjects
Adolescent, Adult, Antipsychotic Agents administration & dosage, Antipsychotic Agents adverse effects, Cognitive Dysfunction etiology, Double-Blind Method, Drug Therapy, Combination, Early Medical Intervention, Female, Humans, Male, Psychotic Disorders complications, Taurine administration & dosage, Taurine adverse effects, Young Adult, Antipsychotic Agents pharmacology, Cognitive Dysfunction drug therapy, Outcome Assessment, Health Care, Psychotic Disorders drug therapy, Taurine pharmacology
Abstract

Objective: Taurine is an inhibitory neuromodulatory amino acid in the central nervous system that activates the GABA- and glycine-insensitive chloride channel and inhibits the N-methyl-D-aspartate receptor. It also functions as a neuroprotective agent and has a role in neural development and neurogenesis. The aim of this study was to determine the efficacy of adjunctive taurine in improving symptomatology and cognition among patients with a DSM-IV first-episode psychotic disorder., Methods: 121 patients with first-episode psychosis, aged 18-25 years, attending early intervention services consented to participate in this randomized, double-blind, placebo-controlled trial conducted from January 2007 to May 2009. Patients taking low-dose antipsychotic medication were randomly assigned to receive once-daily taurine 4 g or placebo for 12 weeks. The coprimary outcomes were change in symptomatology (measured by the Brief Psychiatric Rating Scale [BPRS] total score) and change in cognition (measured by the Measurement and Treatment Research to Improve Cognition in Schizophrenia [MATRICS] Consensus Cognitive Battery composite score) at 12 weeks. Secondary outcomes included tolerability and safety and additional clinical and functioning measures., Results: 86 participants (n = 47 taurine; n = 39 placebo) were included in the final analysis. Taurine significantly improved symptomatology measured by the BPRS total score (95% CI, 1.8-8.5; P = .004) and psychotic subscale (95% CI, 0.1-1.5; P = .026) compared to placebo. Additionally, improvements were observed in the Calgary Depression Scale for Schizophrenia (95% CI, 0.1-3.0; P = .047) and Global Assessment of Functioning (95% CI, 0.3-8.8; P = .04) scores. There was no group difference in composite cognitive score (95% CI, -1.7 to 1.0; P = .582). A significant group difference was found on one safety and tolerability item (psychic item 2, asthenia/lassitude/increased fatigability) of the Udvalg for Kliniske Undersogelser, with the taurine group showing a more favorable outcome (P = .006)., Conclusions: Adjunctive taurine did not improve cognition, but it appears to improve psychopathology in patients with first-episode psychosis. The use of taurine warrants further investigation in larger randomized studies, particularly early in the course of psychosis., Trial Registration: ClinicalTrials.gov identifier: NCT00420823., (© Copyright 2016 Physicians Postgraduate Press, Inc.)

Published
2016
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