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13 results on '"Phani, Sudarshan"'

1. Real-World Treatment Patterns and Clinical Outcomes Among Patients with Metastatic or Unresectable EGFR-Mutated Non-Small Cell Lung Cancer Previously Treated with Osimertinib and Platinum-Based Chemotherapy

Author

Patel, Jyoti, Meng, Jie, Le, Hoa, Tanaka, Yoko, Phani, Sudarshan, Salas, Maribel, Wu, Chuntao, Sternberg, David, Esker, Stephen, Anderson, Jeffrey P., Crowley, Aaron, Zhou, Summera Q., Lieb, Camryn, Sun, Haiyan, Doan, Quan V., Santhanagopal, Anu, and Reckamp, Karen L.

Published
2024
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2. Abstract 6754: Clinical characteristics, real-world treatment patterns, and clinical outcomes among patients with previously treated metastatic or unresectable EGFR-mutated non-small cell lung cancer in the United States

Author

Patel, Jyoti D., primary, Meng, Jie, additional, Phani, Sudarshan, additional, Crowley, Aaron, additional, Zhou, Summera, additional, Salas, Maribel, additional, Tanaka, Yoko, additional, Le, Hoa, additional, Anderson, Jeffrey, additional, and Reckamp, Karen L., additional

Published
2023
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4. A Comprehensive Survey of Managed Care Organization (MCO) Medication Adherence Intervention Programs

Author

Jones, Clifford, primary, Piracha, Fawad, additional, Ng, Kenny, additional, Sullivan, Ian, additional, Boice, Michael, additional, Coutts, David, additional, Mazlish, Stefanie, additional, Nagarian, Aishwarya, additional, Alex, Slanix Paul, additional, Phani, Sudarshan, additional, Shah, Kalee, additional, Sheth, Aneesh, additional, Sip, Kamila, additional, Van Kempen, Tracey, additional, and Basu Roy, Upal, additional

Published
2016
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5. Classic and New Animal Models of Parkinson's Disease

Author

Blesa, Javier, Phani, Sudarshan, Jackson-Lewis, Vernice, and Przedborski, Serge

Subjects
Article Subject
Abstract

Neurological disorders can be modeled in animals so as to recreate specific pathogenic events and behavioral outcomes. Parkinson’s Disease (PD) is the second most common neurodegenerative disease of an aging population, and although there have been several significant findings about the PD disease process, much of this process still remains a mystery. Breakthroughs in the last two decades using animal models have offered insights into the understanding of the PD disease process, its etiology, pathology, and molecular mechanisms. Furthermore, while cellular models have helped to identify specific events, animal models, both toxic and genetic, have replicated almost all of the hallmarks of PD and are useful for testing new neuroprotective or neurorestorative strategies. Moreover, significant advances in the modeling of additional PD features have come to light in both classic and newer models. In this review, we try to provide an updated summary of the main characteristics of these models as well as the strengths and weaknesses of what we believe to be the most popular PD animal models. These models include those produced by 6-hydroxydopamine (6-OHDA), 1-methyl-1,2,3,6-tetrahydropiridine (MPTP), rotenone, and paraquat, as well as several genetic models like those related to alpha-synuclein, PINK1, Parkin and LRRK2 alterations.

Published
2012
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6. The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis

Author

Ikiz, Burcin, primary, Alvarez, Mariano J., additional, Ré, Diane B., additional, Le Verche, Virginia, additional, Politi, Kristin, additional, Lotti, Francesco, additional, Phani, Sudarshan, additional, Pradhan, Radhika, additional, Yu, Changhao, additional, Croft, Gist F., additional, Jacquier, Arnaud, additional, Henderson, Christopher E., additional, Califano, Andrea, additional, and Przedborski, Serge, additional

Published
2015
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8. Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

Author

Re, Diane B., primary, Le Verche, Virginia, additional, Yu, Changhao, additional, Amoroso, Mackenzie W., additional, Politi, Kristin A., additional, Phani, Sudarshan, additional, Ikiz, Burcin, additional, Hoffmann, Lucas, additional, Koolen, Martijn, additional, Nagata, Tetsuya, additional, Papadimitriou, Dimitra, additional, Nagy, Peter, additional, Mitsumoto, Hiroshi, additional, Kariya, Shingo, additional, Wichterle, Hynek, additional, Henderson, Christopher E., additional, and Przedborski, Serge, additional

Published
2014
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9. Gene expression studies of the VTA in an animal model of Parkinson's disease and the emergence of gremlin as a dopaminergic neuroprotective factor

Author

Phani, Sudarshan and Phani, Sudarshan

Abstract

Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disorder afflicting as many as one million Americans and is thought to arise from a loss of dopamine (DA) signaling in the striatum due to the progressive degeneration of DA neurons of the Substantia Nigra (SN). Importantly, neighboring DA cells of the Ventral Tegmental Area (VTA) are relatively spared, raising the hypothesis that there are factors intrinsic to the VTA that are neuroprotective. The studies presented in this thesis aimed to test this hypothesis. Studies were conducted by generating an MPTP mouse model of PD, followed by genomic scale gene expression analysis of the DA neurons of the SN and VTA. Examination of the results revealed that the VTA has a dynamic transcriptional response to MPTP treatment. This response encompasses many areas of cellular function, including protein regulation, ion/metal regulation, and increased expression of peptides thought to be neuroprotective. Notably, this response was largely absent in the cells of the SN. Following gene expression analysis, we set out to develop a primary culture assay system in which to test VTA derived neuroprotective factors in the absence of VTA neurons. We were successfully able to separate SN and VTA neurons from the mouse midbrain, and culture them independent of each other, thus creating a model system in which to test VTA derived protective factors. One such factor identified as being upregulated in the VTA was gremlin. Using cell lines, primary cell culture, and a mouse model of PD, we showed that gremlin was neuroprotective against MPTP/MPP+ both in vivo and in vitro. Moreover, we demonstrated that the protective activity of gremlin was dependent on the VEGF receptor-MAP kinase signaling pathway. In conclusion, these studies provide strong evidence that the VTA has an active response to MPTP insult, including the upregulation of many potentially protective factors, such as gremlin. In the future, these studies may aid

Published
2011

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