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Your search keyword '"Phani, Nagaraja M."' showing total 12 results
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12 results on '"Phani, Nagaraja M."'

2. Characterization of 40 novel HLA class I and class II alleles identified in umbilical cord blood units.

Author

Rajendran, Sureka, Murugan, Alagupandian, Nandakumar, Yogesh, Chaturvedi, Ankur, Phani, Nagaraja M., Padhiar, Chirayu, Goditala, Pardhasaradhi, and Gambhir, Prakash Sadashiv

Subjects
FRAMESHIFT mutation, CORD blood, SINGLE nucleotide polymorphisms, ALLELES
Abstract

Forty novel HLA class I and class II alleles were identified in umbilical cord blood (UCB) samples and categorized based on various types of mutations: non‐synonymous, synonymous, frameshift, and premature termination codon. This study described 14 novel HLA‐A alleles, 9 novel HLA‐B alleles, 4 novel HLA‐C alleles, 3 novel HLA‐DRB1 alleles and 10 novel HLA‐DQB1 alleles. Comparing the new allele sequence with the most homologous sequence, 60% of the novel alleles exhibited non‐synonymous substitution, 32.5% observed with synonymous substitution, 5% displayed premature stop codon, and 2.5% presented with frameshift mutation. The majority of the new alleles contained a single nucleotide variation when compared with the most similar sequence. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Population Specific Impact of Genetic Variants in KCNJ11 Gene to Type 2 Diabetes: A Case-Control and Meta-Analysis Study

Author

Phani, Nagaraja M., primary, Guddattu, Vasudeva, additional, Bellampalli, Ravishankara, additional, Seenappa, Venu, additional, Adhikari, Prabha, additional, Nagri, Shivashankara K., additional, D′Souza, Sydney C., additional, Mundyat, Gopinath P., additional, Satyamoorthy, Kapaettu, additional, and Rai, Padmalatha S., additional

Published
2014
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12. Significance of 5,10-methylenetetrahydrofolate reductase gene variants in acute lymphoblastic leukemia in Indian population: an experimental, computational and meta-analysis.

Author

Bellampalli, Ravishankara, Phani, Nagaraja M., Bhat, Kamalakshi G., Prasad, Krishna, Bhaskaranand, Nalini, Guruprasad, Kanive P., Rai, Padmalatha S., and Satyamoorthy, Kapaettu

Subjects
*METHYLENETETRAHYDROFOLATE reductase, *LYMPHOBLASTIC leukemia, *META-analysis, *SINGLE nucleotide polymorphisms, *MICRORNA, *CASE-control method, *PATIENTS
Abstract

Acute lymphoblastic leukemia (ALL) arises due to several genetic alterations in progenitor cells, and methotrexate is frequently used as part of the treatment regimen. Although there is evidence for an effect of 5,10-methylenetetrahydrofolate reductase gene ( MTHFR) C677T and A1298C variations on drug response in ALL, its risk association for ALL is still unresolved. In a case-control study of 203 patients with ALL and 246 controls and meta-analysis in the Indian population, we showed an insignificant association of MTHFR C677T and A1298C genotypes with childhood and adult ALL. Comprehensive in silico characterization of non-synonymous single nucleotide polymorphisms (nsSNPs) and SNPs of the 3′ untranslated region (UTR) revealed nine nsSNPs as deleterious, and three SNPs in the 3′UTR could possibly alter the binding of miRNAs. The study revealed that several overlooked SNPs may contribute to the risk of ALL susceptibility and further studies of these SNPs with functional characterization in a large sample size are required to understand the significant role of MTHFR in ALL development. [ABSTRACT FROM AUTHOR]

Published
2015
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