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6 results on '"Phan, Tom"'

1. Innovations in medical education in Vietnam

Author

Duong, David B, primary, Phan, Tom, additional, Trung, Nguyen Quang, additional, Le, Bao Ngoc, additional, Do, Hoa Mai, additional, Nguyen, Hoang Minh, additional, Tang, Sang Hung, additional, Pham, Van-Anh, additional, Le, Bao Khac, additional, Le, Linh Cu, additional, Siddiqui, Zarrin, additional, Cosimi, Lisa A, additional, and Pollack, Todd, additional

Published
2021
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2. Purification and Analysis of in Vivo-Differentiated Oligodendrocytes Expressing the Green Fluorescent Protein

Author

Fuss, Babette, Mallon, Barbara, Phan, Tom, Ohlemeyer, Carsten, Kirchhoff, Frank, Nishiyama, Akiko, and Macklin, Wendy B.

Subjects
Developmental biology -- Research, Oligodendroglia -- Research, Cell differentiation -- Research, Biological sciences
Abstract

A complete understanding of the molecular mechanisms involved in the formation and repair of the central nervous system myelin sheath requires an unambiguous identification and isolation of in vivo-differentiated myelin-forming cells. In order to develop a novel tool for the analysis of in vivo-differentiated oligodendrocytes, we generated transgenic mice expressing a red-shifted variant of the green fluorescent protein under the control of the proteolipid protein promoter. We demonstrate here that green fluorescent protein-derived fluorescence in the central nervous system of 9-day- to 7-week-old mice is restricted to mature oligodendrocytes, as determined by its spatiotemporal appearance and by both immunocytochemical and electrophysiological criteria. Green fluorescent protein-positive oligodendrocytes could easily be visualized in live and fixed tissue. Furthermore, we show that this convenient and reliable identification now allows detailed physiological analyses of differentiated oligodendrocytes in situ. In addition, we developed a novel tissue culture system for in vivo-differentiated oligodendrocytes. Initial data using this system indicate that, for oligodendrocytes isolated after differentiation in vivo, as yet unidentified factors secreted by astrocytes are necessary for survival and/or reappearance of a mature phenotype in culture.

Published
2000

4. Oral History of Tom Phan

Author

Vo Dang, Thuy, Phan, Tom, Vo Dang, Thuy, and Phan, Tom

Abstract

An oral history with Mr. Tom Phan, born in 1955 in Nha Trang, Vietnam. In March 1975, Mr. Phan was a teenager attending boarding school in Da Lat when Vietnam fell. On April 27, 1975, his family flew from Saigon to the United States. Mr. Phan enrolled in the local university majoring in computer engineering, and worked minimum wage jobs. In 1978, he was the first Asian hired at Electronic Data Systems, where he worked for eight years. On December 15, 1978, he married his wife. In 1988, he formed his own company, Customer Focus International, which developed software. In 1998 he sold the company and retired. During his retirement, he spent more time with his family and took them on many vacations, including taking his entire extended family to Vietnam for a month in 2000. In 2007, his son approached him about opening a Vietnamese restaurant, which is now called Phans 55. It currently has two locations in Irvine and Fullerton. He has children and lives in Irvine, California with his wife., Recorded Digitally

Published
2013

6. Six-months assessment of a hand prosthesis with intraneural tactile feedback

Author

Petrini, Francesco, Valle, Giacomo, Strauss, Ivo, Granata, Giuseppe, Di Iorio, Riccardo, d'Anna, Edoardo, Čvančara, Paul, Mueller, Matthias, Carpaneto, Jacopo, Clemente, Francesco, Controzzi, Marco, Bisoni, Lorenzo, Carboni, Caterina, Barbaro, Michael, Iodice, Francesco, Andreu, David, Hiairrassary, Arthur, Divoux, Jean-Louis, Cipriani, Christian, Guiraud, David, Raffo, Luigi, Fernandez, Eduardo, Stieglitz, Thomas, Raspopovic, Stanisa, Rossini, Paolo Maria, Micera, Silvestro, Fondation Bertarelli Chair inTranslational Neuroscience and Neuroengineering [Lausanne], Center for Neuroprosthetics and Institute of Bioengineering, EPFL.-Fondation Bertarelli, Università cattolica del Sacro Cuore [Roma] (Unicatt), Fondazione 'Policlinico Universitario A. Gemelli' [Rome], Bernstein Center Freiburg (BCF), Albert-Ludwigs-Universität Freiburg, Scuola Universitaria Superiore Sant'Anna [Pisa] (SSSUP), Department of Electrical and Electronic Engineering [University of Cagliari] (DIEE), University of Cagliari, Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), MXM-AXONIC, University of Freiburg [Freiburg], Department of Health Sciences and Technology [ETH Zürich] (D-HEST), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), This work was supported by EU grant CP-FP-INFSO224012 (TIME project), the project NEMESIS (Neurocontrolled Mechatronic Hand Prosthesis) funded by the Italian Ministry of Health, EU grant FP7-611687 (NEBIAS, NEurocontrolled BIdirectional Artificial upperlimb and hand prosthesiS), EU grant FP7-HEALTH-1602547 (EPIONE, Natural Sensory Feedback for Phan-tom Limb Pain Modulation and Therapy), the SwissNational Science Foundation through the National Center of Competence in Research Robotics, and the Bertarelli Foundation., European Project: 602547,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,EPIONE(2013), European Project: 611687,EC:FP7:ICT,FP7-ICT-2013-10,NEBIAS(2013), Ecole Polytechnique Fédérale de Lausanne (EPFL)-Fondation Bertarelli, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM)

Subjects
Neuroprosthetics, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Neural stimulation, Sensory feedback, [SPI.AUTO]Engineering Sciences [physics]/Automatic
Abstract

International audience; OBJECTIVE:Hand amputation is a highly disabling event, which significantly affects quality of life. An effective hand replacement can be achieved if the user, in addition to motor functions, is provided with the sensations that are naturally perceived while grasping and moving. Intraneural peripheral electrodes have shown promising results toward the restoration of the sense of touch. However, the long-term usability and clinical relevance of intraneural sensory feedback have not yet been clearly demonstrated.METHODS:To this aim, we performed a six months clinical study with three trans-radial amputees who received implants of transverse intrafascicular multichannel electrodes (TIMEs) in their median and ulnar nerves. After calibration, electrical stimulation was delivered through the TIMEs connected to artificial sensors in the digits of a prosthesis to generate sensory feedback, which was then used by the subjects while performing different grasping tasks.RESULTS:All the subjects, notwithstanding their important clinical differences, reported stimulation-induced sensations from the phantom hand for the whole duration of the trial. They also successfully integrated the sensory feedback into their motor control strategies while performing experimental tests simulating tasks of real life (with and without the support of vision). Finally, they reported a decrement of their phantom limb pain and a general improvement in mood state.INTERPRETATION:The promising results achieved with all subjects show the feasibility of the use of intraneural stimulation in clinical settings.

Published
2019
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