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4. Fading SARS-CoV-2 humoral VOC cross-reactivity and sustained cellular immunity in convalescent children and adolescents

Author

Paniskaki, Krystallenia, Goretzki, Sarah, Anft, Moritz, Konik, Margarethe J., Lechtenberg, Klara, Vogl, Melanie, Meister, Toni L., Pfaender, Stephanie, Zettler, Markus, Jäger, Jasmin, Dolff, Sebastian, Westhoff, Timm H., Rohn, Hana, Felderhoff-Mueser, Ursula, Stervbo, Ulrik, Witzke, Oliver, Dohna-schwake, Christian, and Babel, Nina

Published
2023
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5. Copper and silver thin film systems display differences in antiviral and antibacterial properties -- implications for the prevention of SARS-CoV-2 infections

Author

Meister, Toni Luise, Fortmann, Jill, Breisch, Marina, Sengstock, Christina, Steinmann, Eike, Koeller, Manfred, Pfaender, Stephanie, and Ludwig, Alfred

Subjects
Physics - Medical Physics, Physics - Biological Physics
Abstract

The current Coronavirus Disease 19 (COVID-19) pandemic has exemplified the need for simple and efficient prevention strategies that can be rapidly implemented to mitigate infection risks. Various surfaces have a long history of antimicrobial properties and are well described for the prevention of bacterial infections. However, their effect on many viruses has not been studied in depth. In the context of COVID-19, several surfaces, including copper (Cu) and silver (Ag) coatings have been described as efficient antiviral measures that can easily be implemented to slow viral transmission. In this study, we detected antiviral properties against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) on surfaces, which were coated with Cu by magnetron sputtering. However, no effect of Ag on viral titers was observed, in clear contrast to its well-known antibacterial properties. Further enhancement of Ag ion release kinetics based on an electrochemical sacrificial anode mechanism did not increase antiviral activity. These results clearly demonstrate that Cu and Ag thin film systems display significant differences in antiviral and antibacterial properties which need to be considered upon implementation.

Published
2021

7. Impact of low eGFR on the immune response against COVID-19

Author

Blazquez-Navarro, Arturo, Mittmann, Lisa, Thieme, Constantin Joachim, Anft, Moritz, Paniskaki, Krystallenia, Doevelaar, Adrian, Seibert, Felix Sebastian, Hoelzer, Bodo, Konik, Margarete Justine, Berger, Marc Moritz, Brenner, Thorsten, Tempfer, Clemens, Watzl, Carsten, Meister, Toni Luise, Pfaender, Stephanie, Steinmann, Eike, Dolff, Sebastian, Dittmer, Ulf, Witzke, Oliver, Stervbo, Ulrik, Roch, Toralf, Or-Guil, Michal, Westhoff, Timm Henning, and Babel, Nina

Published
2023
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8. Exploring the relationship between HCMV serostatus and outcomes in COVID-19 sepsis

Author

Ziehe, Dominik, primary, Wolf, Alexander, additional, Rahmel, Tim, additional, Nowak, Hartmuth, additional, Haberl, Helge, additional, Bergmann, Lars, additional, Rump, Katharina, additional, Dyck, Birte, additional, Palmowski, Lars, additional, Marko, Britta, additional, Witowski, Andrea, additional, Willemsen, Katrin Maria, additional, Pfaender, Stephanie, additional, Eisenacher, Martin, additional, Anft, Moritz, additional, Babel, Nina, additional, Bracht, Thilo, additional, Sitek, Barbara, additional, Bayer, Malte, additional, Zarbock, Alexander, additional, von Groote, Thilo, additional, Putensen, Christian, additional, Ehrentraut, Stefan Felix, additional, Weisheit, Christina, additional, Adamzik, Michael, additional, Unterberg, Matthias, additional, and Koos, Björn, additional

Published
2024
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9. SARS-CoV-2 infects human cardiomyocytes promoted by inflammation and oxidative stress

Author

Tangos, Melina, Budde, Heidi, Kolijn, Detmar, Sieme, Marcel, Zhazykbayeva, Saltanat, Lódi, Mária, Herwig, Melissa, Gömöri, Kamilla, Hassoun, Roua, Robinson, Emma Louise, Meister, Toni Luise, Jaquet, Kornelia, Kovács, Árpád, Mustroph, Julian, Evert, Katja, Babel, Nina, Fagyas, Miklós, Lindner, Diana, Püschel, Klaus, Westermann, Dirk, Mannherz, Hans Georg, Paneni, Francesco, Pfaender, Stephanie, Tóth, Attila, Mügge, Andreas, Sossalla, Samuel, and Hamdani, Nazha

Published
2022
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10. Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication

Author

Stegmann, Kim M., Dickmanns, Antje, Heinen, Natalie, Blaurock, Claudia, Karrasch, Tim, Breithaupt, Angele, Klopfleisch, Robert, Uhlig, Nadja, Eberlein, Valentina, Issmail, Leila, Herrmann, Simon T., Schreieck, Amelie, Peelen, Evelyn, Kohlhof, Hella, Sadeghi, Balal, Riek, Alexander, Speakman, John R., Groß, Uwe, Görlich, Dirk, Vitt, Daniel, Müller, Thorsten, Grunwald, Thomas, Pfaender, Stephanie, Balkema-Buschmann, Anne, and Dobbelstein, Matthias

Published
2022
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13. The triglyceride-synthesizing enzyme diacylglycerol acyltransferase 2 modulates the formation of the hepatitis C virus replication organelle.

Author

Reichert, Isabelle, Lee, Ji-Young, Weber, Laura, Fuh, Marceline M., Schlaeger, Lina, Rößler, Stefanie, Kinast, Volker, Schlienkamp, Sarah, Conradi, Janina, Vondran, Florian W. R., Pfaender, Stephanie, Scaturro, Pietro, Steinmann, Eike, Bartenschlager, Ralf, Pietschmann, Thomas, Heeren, Joerg, Lauber, Chris, and Vieyres, Gabrielle

Subjects
HEPATITIS C virus, UNSATURATED fatty acids, INTRACELLULAR membranes, ENDOPLASMIC reticulum, HEPATITIS C
Abstract

The replication organelle of hepatitis C virus (HCV), called membranous web, is derived from the endoplasmic reticulum (ER) and mainly comprises double membrane vesicles (DMVs) that concentrate the viral replication complexes. It also tightly associates with lipid droplets (LDs), which are essential for virion morphogenesis. In particular acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), a rate-limiting enzyme in triglyceride synthesis, promotes early steps of virus assembly. The close proximity between ER membranes, DMVs and LDs therefore permits the efficient coordination of the HCV replication cycle. Here, we demonstrate that exaggerated LD accumulation due to the excessive expression of the DGAT1 isozyme, DGAT2, dramatically impairs the formation of the HCV membranous web. This effect depended on the enzymatic activity and ER association of DGAT2, whereas the mere LD accumulation was not sufficient to hamper HCV RNA replication. Our lipidomics data indicate that both HCV infection and DGAT2 overexpression induced membrane lipid biogenesis and markedly increased phospholipids with long chain polyunsaturated fatty acids, suggesting a dual use of these lipids and their possible competition for LD and DMV biogenesis. On the other hand, overexpression of DGAT2 depleted specific phospholipids, particularly oleyl fatty acyl chain-containing phosphatidylcholines, which, in contrast, are increased in HCV-infected cells and likely essential for viral infection. In conclusion, our results indicate that lipid exchanges occurring during LD biogenesis regulate the composition of intracellular membranes and thereby affect the formation of the HCV replication organelle. The potent antiviral effect observed in our DGAT2 overexpression system unveils lipid flux that may be relevant in the context of steatohepatitis, a hallmark of HCV infection, but also in physiological conditions, locally in specific subdomains of the ER membrane. Thus, LD formation mediated by DGAT1 and DGAT2 might participate in the spatial compartmentalization of HCV replication and assembly factories within the membranous web. Author summary: Lipid droplets are fat storage organelles with an increasingly recognized importance for the infectious cycle of multiple pathogens. In particular, they support hepatitis C virion morphogenesis and the formation of the picornaviral replication organelle. Unexpectedly, we observed that exaggerated lipid droplet biogenesis, due to an excessive expression of the triglyceride forming enzyme DGAT2, is deleterious to hepatitis C virus replication. More precisely, the formation and maintenance of the viral replication organelle was impeded. Exaggerated lipid droplet biogenesis induced by DGAT2 also profoundly altered the cell lipidome, with strong accumulation of neutral lipids and changes in the membrane lipid composition. Our results support a model where lipid flux occurring during lipid droplet biogenesis regulates the composition of the endoplasmic reticulum membranes, where lipid droplets are formed, and thereby affect the capacity of hepatitis C virus to remodel these membranes into its replication organelle. Since DGAT1 and its triglyceride synthesis were previously reported to contribute to virus assembly, this also implies that lipid droplet biogenesis driven by DGAT1 and DGAT2 but also membrane contact sites between endoplasmic reticulum and lipid droplets might locally restrict and determine the formation of hepatitis C virus replication and assembly factories. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients

Author

Thieme, Constantin J., Anft, Moritz, Paniskaki, Krystallenia, Blazquez-Navarro, Arturo, Doevelaar, Adrian, Seibert, Felix S., Hoelzer, Bodo, Konik, Margarethe Justine, Berger, Marc Moritz, Brenner, Thorsten, Tempfer, Clemens, Watzl, Carsten, Meister, Toni L., Pfaender, Stephanie, Steinmann, Eike, Dolff, Sebastian, Dittmer, Ulf, Westhoff, Timm H., Witzke, Oliver, Stervbo, Ulrik, Roch, Toralf, and Babel, Nina

Published
2020
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17. Productive infection of primary human hepatocytes with SARS-CoV-2 induces antiviral and proinflammatory responses

Author

Heinen, Natalie, primary, Khanal, Rajendra, additional, Westhoven, Saskia, additional, Klöhn, Mara, additional, Herrmann, Simon T, additional, Herrmann, Maike, additional, Tuoc, Tran, additional, Ulmke, Pauline Antonie, additional, Nguyen, Hoang Duy, additional, Nguyen, Huu Phuc, additional, Steinmann, Eike, additional, Todt, Daniel, additional, Brown, Richard J P, additional, Sharma, Amar Deep, additional, and Pfaender, Stephanie, additional

Published
2023
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18. Natural and hybrid immunity after SARS-CoV-2 infection in children and adolescents

Author

Rothoeft, Tobias, primary, Maier, Christoph, additional, Talarico, Adriana, additional, Hoffmann, Anna, additional, Schlegtendal, Anne, additional, Lange, Berit, additional, Petersmann, Astrid, additional, Denz, Robin, additional, Timmesfeld, Nina, additional, Toepfner, Nicole, additional, Vidal-Blanco, Elena, additional, Pfaender, Stephanie, additional, Lücke, Thomas, additional, and Brinkmann, Folke, additional

Published
2023
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19. LY6E impairs coronavirus fusion and confers immune control of viral disease

Author

Pfaender, Stephanie, Mar, Katrina B., Michailidis, Eleftherios, Kratzel, Annika, Boys, Ian N., V’kovski, Philip, Fan, Wenchun, Kelly, Jenna N., Hirt, Dagny, Ebert, Nadine, Stalder, Hanspeter, Kleine-Weber, Hannah, Hoffmann, Markus, Hoffmann, Hans-Heinrich, Saeed, Mohsan, Dijkman, Ronald, Steinmann, Eike, Wight-Carter, Mary, McDougal, Matthew B., Hanners, Natasha W., Pöhlmann, Stefan, Gallagher, Tom, Todt, Daniel, Zimmer, Gert, Rice, Charles M., Schoggins, John W., and Thiel, Volker

Published
2020
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20. Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 by WHO-Recommended Hand Rub Formulations and Alcohols

Author

Kratzel, Annika, Todt, Daniel, Vkovski, Philip, Steiner, Silvio, Gultom, Mitra, Thao, Tran Thi Nhu, Ebert, Nadine, Holwerda, Melle, Steinmann, Jorg, Niemeyer, Daniela, Dijkman, Ronald, Kampf, Gunter, Drosten, Christian, Steinmann, Eike, Thiel, Volker, and Pfaender, Stephanie

Subjects
Severe acute respiratory syndrome -- Health aspects, Alcohols -- Health aspects, Coronaviruses -- Health aspects, COVID-19 -- Health aspects, Health
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third highly pathogenic human coronavirus to cross the species barrier into the human population during the past 20 years (2-3). SARS-CoV-2 [...]

Published
2020
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21. Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

Author

Thi Nhu Thao, Tran, Labroussaa, Fabien, Ebert, Nadine, V’kovski, Philip, Stalder, Hanspeter, Portmann, Jasmine, Kelly, Jenna, Steiner, Silvio, Holwerda, Melle, Kratzel, Annika, Gultom, Mitra, Schmied, Kimberly, Laloli, Laura, Hüsser, Linda, Wider, Manon, Pfaender, Stephanie, Hirt, Dagny, Cippà, Valentina, Crespo-Pomar, Silvia, Schröder, Simon, Muth, Doreen, Niemeyer, Daniela, Corman, Victor M., Müller, Marcel A., Drosten, Christian, Dijkman, Ronald, Jores, Joerg, and Thiel, Volker

Published
2020
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22. The Magnitude and Functionality of SARS-CoV-2 Reactive Cellular and Humoral Immunity in Transplant Population Is Similar to the General Population Despite Immunosuppression

Author

Thieme, Constantin J., Anft, Moritz, Paniskaki, Krystallenia, Blazquez-Navarro, Arturo, Doevelaar, Adrian, Seibert, Felix S., Hoelzer, Bodo, Justine Konik, Margarethe, Meister, Toni L., Pfaender, Stephanie, Steinmann, Eike, Moritz Berger, Marc, Brenner, Thorsten, Kölsch, Uwe, Dolff, Sebastian, Roch, Toralf, Witzke, Oliver, Schenker, Peter, Viebahn, Richard, Stervbo, Ulrik, Westhoff, Timm H., and Babel, Nina

Published
2021
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23. Immune protection against reinfection with nonprimate hepacivirus

Author

Pfaender, Stephanie, Walter, Stephanie, Grabski, Elena, Todt, Daniel, Bruening, Janina, Romero-Brey, Inés, Gather, Theresa, Brown, Richard J. P., Hahn, Kerstin, Puff, Christina, Pfankuche, Vanessa M., Hansmann, Florian, Postel, Alexander, Becher, Paul, Thiel, Volker, Kalinke, Ulrich, Wagner, Bettina, Bartenschlager, Ralf, Baumgärtner, Wolfgang, Feige, Karsten, Pietschmann, Thomas, Cavalleri, Jessika M. V., and Steinmann, Eike

Published
2017

24. Virucidal Activity of World Health Organization–Recommended Formulations Against Enveloped Viruses, Including Zika, Ebola, and Emerging Coronaviruses

Author

Siddharta, Anindya, Pfaender, Stephanie, Vielle, Nathalie Jane, Dijkman, Ronald, Friesland, Martina, Becker, Britta, Yang, Jaewon, Engelmann, Michael, Todt, Daniel, Windisch, Marc P., Brill, Florian H., Steinmann, Joerg, Steinmann, Jochen, Becker, Stephan, Alves, Marco P., Pietschmann, Thomas, Eickmann, Markus, Thiel, Volker, and Steinmann, Eike

Published
2017

26. Increased SARS‐CoV‐2 reactive low avidity T cells producing inflammatory cytokines in pediatric post‐acute COVID‐19 sequelae (PASC).

Author

Paniskaki, Krystallenia, Goretzki, Sarah, Anft, Moritz, Konik, Margarethe J., Meister, Toni L., Pfaender, Stephanie, Lechtenberg, Klara, Vogl, Melanie, Dogan, Burcin, Dolff, Sebastian, Westhoff, Timm H., Rohn, Hana, Felderhoff‐Mueser, Ursula, Stervbo, Ulrik, Witzke, Oliver, Dohna‐Schwake, Christian, and Babel, Nina

Subjects
T cells, POST-acute COVID-19 syndrome, MENTAL illness, SARS-CoV-2, COVID-19, CHEST pain, TASTE disorders
Abstract

Background: A proportion of the convalescent SARS‐CoV‐2 pediatric population presents nonspecific symptoms, mental health problems, and a reduction in quality of life similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID‐19 symptomatic. However, data regarding its clinical manifestation and immune mechanisms are currently scarce. Methods: In this study, we perform a comprehensive clinical and immunological profiling of 17 convalescent COVID‐19 children with post‐acute COVID‐19 sequelae (PASC) manifestation and 13 convalescent children without PASC manifestation. A detailed medical history, blood and instrumental tests, and physical examination were obtained from all patients. SARS‐CoV‐2 reactive T‐cell response was analyzed via multiparametric flow cytometry and the humoral immunity was addressed via pseudovirus neutralization and ELISA assay. Results: The most common PASC symptoms were shortness of breath/exercise intolerance, paresthesia, smell/taste disturbance, chest pain, dyspnea, headache, and lack of concentration. Blood count and clinical chemistry showed no statistical differences among the study groups. We detected higher frequencies of spike (S) reactive CD4+ and CD8+ T cells among the PASC study group, characterized by TNFα and IFNγ production and low functional avidity. CRP levels are positively correlated with IFNγ producing reactive CD8+ T cells. Conclusions: Our data might indicate a possible involvement of a persistent cellular inflammatory response triggered by SARS‐CoV‐2 in the development of the observed sequelae in pediatric PASC. These results may have implications on future therapeutic and prevention strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Significant Fade of Neutralizing Antibodies and Stable Cellular Immunity in 4 Times COVID-19 Vaccinated Noninfected Compared to COVID-19 Convalescent and 3 Times Vaccinated Hemodialysis Patients

Author

Anft, Moritz, primary, Skrzypczyk, Sarah, additional, Frahnert, Michael, additional, Fricke, Lutz, additional, Zapka, Jan, additional, Kühn, Daniel, additional, Koos, Björn, additional, Adamzik, Michael, additional, Pfaender, Stephanie, additional, Stervbo, Ulrik, additional, Westhoff, Timm H., additional, and Babel, Nina, additional

Published
2023
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28. Relevance of microRNAs in SARS-CoV-2 infection of primary human hepatocytes

Author

Khanal, Rajendra, additional, Heinen, Natalie, additional, Bogomolova, Alexandra, additional, Meister, ToniLuise, additional, Todt, Daniel, additional, Jockenhövel, Freya, additional, Vondran, Florian, additional, Brown, RichardJ.P., additional, Steinmann, Eike, additional, Zimmer, Gert, additional, Ott, Michael, additional, Pfaender, Stephanie, additional, and Sharma, AmarDeep, additional

Published
2023
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29. SARS-CoV-2 vaccination improves HBV seroconversion rate through heterological immunity

Author

Anft, Moritz, primary, Paniskaki, Krystallenia, additional, Giglio, Tina, additional, Wellenkötter, Jacqueline, additional, Blazquez-Navarro, Arturo, additional, Meister, Toni L., additional, Roch, Toralf, additional, Giesecke-Thiel, Claudia, additional, Westhoff, Timm H., additional, Stervbo, Ulrik, additional, Pfaender, Stephanie, additional, Cinkilic, Okan, additional, and Babel, Nina, additional

Published
2023
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32. Low avidity circulating SARS-CoV-2 reactive CD8+ T cells with proinflammatory TEMRA phenotype are associated with post-acute sequelae of COVID-19

Author

Paniskaki, Krystallenia, Konik, Margarethe J., Anft, Moritz, Heidecke, Harald, Meister, Toni L., Pfaender, Stephanie, Krawczyk, Adalbert, Zettler, Markus, Jäger, Jasmin, Gaeckler, Anja, Dolff, Sebastian, Westhoff, Timm H., Rohn, Hana, Stervbo, Ulrik, Scheibenbogen, Carmen, Witzke, Oliver, and Babel, Nina

Subjects
Microbiology (medical), Medizin, Microbiology
Abstract

The role of adaptive SARS-CoV-2 specific immunity in post-acute sequelae of COVID-19 (PASC) is not well explored, although a growing population of convalescent COVID-19 patients with manifestation of PASC is observed. We analyzed the SARS-CoV-2-specific immune response, via pseudovirus neutralizing assay and multiparametric flow cytometry in 40 post-acute sequelae of COVID-19 patients with non-specific PASC manifestation and 15 COVID-19 convalescent healthy donors. Although frequencies of SARS-CoV-2-reactive CD4+ T cells were similar between the studied cohorts, a stronger SARS-CoV-2 reactive CD8+ T cell response, characterized by IFNγ production and predominant TEMRA phenotype but low functional TCR avidity was detected in PASC patients compared to controls. Of interest, high avidity SARS-CoV-2-reactive CD4+ and CD8+ T cells were comparable between the groups demonstrating sufficient cellular antiviral response in PASC. In line with the cellular immunity, neutralizing capacity in PASC patients was not inferior compared to controls. In conclusion, our data suggest that PASC may be driven by an inflammatory response triggered by an expanded population of low avidity SARS-CoV-2 reactive pro-inflammatory CD8+ T cells. These pro-inflammatory T cells with TEMRA phenotype are known to be activated by a low or even without TCR stimulation and lead to a tissue damage. Further studies including animal models are required for a better understanding of underlying immunopathogensis. Summary: A CD8+ driven persistent inflammatory response triggered by SARS-CoV-2 may be responsible for the observed sequelae in PASC patients. CA extern

Published
2023

33. Increased migratory/activated CD8+ T cell and low avidity SARS-CoV-2 reactive cellular response in post-acute COVID-19 syndrome

Author

Paniskaki, Krystallenia, primary, Konik, Margarethe J., additional, Anft, Moritz, additional, Heidecke, Harald, additional, Meister, Toni L., additional, Pfaender, Stephanie, additional, Krawczyk, Adalbert, additional, Zettler, Markus, additional, Jäger, Jasmin, additional, Gaeckler, Anja, additional, Dolff, Sebastian, additional, Westhoff, Timm H., additional, Rohn, Hana, additional, Stervbo, Ulrik, additional, Scheibenbogen, Carmen, additional, Witzke, Oliver, additional, and Babel, Nina, additional

Published
2022
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34. Impact of SARS-CoV-2 vaccination on systemic immune responses in people living with HIV

Author

Bessen, Clara, primary, Plaza-Sirvent, Carlos, additional, Simsek, Agit, additional, Bhat, Jaydeep, additional, Marheinecke, Corinna, additional, Urlaub, Doris, additional, Bonowitz, Petra, additional, Busse, Sandra, additional, Schumann, Sabrina, additional, Blanco, Elena Vidal, additional, Skaletz-Rorowski, Adriane, additional, Brockmeyer, Norbert H., additional, Overheu, Oliver, additional, Reinacher-Schick, Anke, additional, Faissner, Simon, additional, Watzl, Carsten, additional, Pfaender, Stephanie, additional, Potthoff, Anja, additional, and Schmitz, Ingo, additional

Published
2022
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35. Superior humoral immunity in vaccinated SARS-CoV-2 convalescence as compared to SARS-COV-2 infection or vaccination

Author

Paniskaki, Krystallenia, primary, Konik, Margarethe J., additional, Anft, Moritz, additional, Meister, Toni L., additional, Marheinecke, Corinna, additional, Pfaender, Stephanie, additional, Jäger, Jasmin, additional, Krawczyk, Adalbert, additional, Zettler, Markus, additional, Dolff, Sebastian, additional, Westhoff, Timm H., additional, Rohn, Hana, additional, Stervbo, Ulrik, additional, Witzke, Oliver, additional, and Babel, Nina, additional

Published
2022
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36. Comparison of disease-modifying anti-rheumatic drugs in inducing immunogenicity to SARS-CoV2 vaccines in adult patients with autoimmune musculoskeletal inflammatory rheumatic diseases

Author

Andreica, Ioana, Blazquez-Navarro, Arturo, Sokolar, Jan, Anft, Moritz, Kiltz, Uta, Pfaender, Stephanie, Vidal Blanco, Elena, Westhoff, Timm, Babel, Nina, Stervbo, Ulrik, and Baraliakos, Xenofon

Subjects
Medicine and health
Abstract

Introduction: The interplay between humoral and cellular response after vaccination against COVID-19 infection in patients with autoimmune inflammatory rheumatic diseases (AIRD) remains unknown. We investigated the impact of 4 different immunosuppressive therapies in AIRD patients under stable low disease [for full text, please go to the a.m. URL]

Published
2022
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37. SARS-CoV-2 neutralizing camelid heavy-chain-only antibodies as powerful tools for diagnostic and therapeutic applications

Author

Schlör, Anja, primary, Hirschberg, Stefan, additional, Amor, Ghada Ben, additional, Meister, Toni Luise, additional, Arora, Prerna, additional, Pöhlmann, Stefan, additional, Hoffmann, Markus, additional, Pfaender, Stephanie, additional, Eddin, Omar Kamal, additional, Kamhieh-Milz, Julian, additional, and Hanack, Katja, additional

Published
2022
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39. Different humoral but similar cellular responses of patients with autoimmune inflammatory rheumatic diseases under disease-modifying antirheumatic drugs after COVID-19 vaccination

Author

Andreica, Ioana, primary, Blazquez-Navarro, Arturo, additional, Sokolar, Jan, additional, Anft, Moritz, additional, Kiltz, Uta, additional, Pfaender, Stephanie, additional, Vidal Blanco, Elena, additional, Westhoff, Timm, additional, Babel, Nina, additional, Stervbo, Ulrik, additional, and Baraliakos, Xenofon, additional

Published
2022
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40. Immune response in ofatumumab treated multiple sclerosis patients after SARS-CoV-2 vaccination

Author

Faissner, Simon, primary, Heitmann, Neele, additional, Plaza-Sirvent, Carlos, additional, Trendelenburg, Paulina, additional, Ceylan, Ulas, additional, Motte, Jeremias, additional, Bessen, Clara, additional, Urlaub, Doris, additional, Watzl, Carsten, additional, Overheu, Oliver, additional, Reinacher-Schick, Anke, additional, Hellwig, Kerstin, additional, Pfaender, Stephanie, additional, Schmitz, Ingo, additional, and Gold, Ralf, additional

Published
2022
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41. SARS-CoV-2 entry route impacts a range of downstream viral and cellular processes

Author

Qu, Bingqian, primary, Miskey, Csaba, additional, Gömer, André, additional, Potmus, Dylan, additional, Nocke, Maximillian, additional, Kleinert, Robin D.V., additional, Itotia, Tabitha K., additional, Valder, Lara, additional, Brückmann, Janice, additional, Höck, Sebastian, additional, Hastert, Florian D., additional, von Rhein, Christine, additional, Schürmann, Christoph, additional, Ebenig, Aileen, additional, Widera, Marek, additional, Ciesek, Sandra, additional, Pfaender, Stephanie, additional, Ivics, Zoltán, additional, Schnierle, Barbara S., additional, Tarr, Alexander W., additional, Goffinet, Christine, additional, Mühlebach, Michael D., additional, Todt, Daniel, additional, and Brown, Richard J.P., additional

Published
2022
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42. Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after TH2-biased immunization

Author

Ebenig, Aileen, primary, Muraleedharan, Samada, additional, Kazmierski, Julia, additional, Todt, Daniel, additional, Auste, Arne, additional, Anzaghe, Martina, additional, Gömer, André, additional, Postmus, Dylan, additional, Gogesch, Patricia, additional, Niles, Marc, additional, Plesker, Roland, additional, Miskey, Csaba, additional, Gellhorn Serra, Michelle, additional, Breithaupt, Angele, additional, Hörner, Cindy, additional, Kruip, Carina, additional, Ehmann, Rosina, additional, Ivics, Zoltan, additional, Waibler, Zoe, additional, Pfaender, Stephanie, additional, Wyler, Emanuel, additional, Landthaler, Markus, additional, Kupke, Alexandra, additional, Nouailles, Geraldine, additional, Goffinet, Christine, additional, Brown, Richard J.P., additional, and Mühlebach, Michael D., additional

Published
2022
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44. Impact of low eGFR on the immune response against COVID-19

Author

Blazquez-Navarro, Arturo, primary, Mittmann, Lisa, additional, Thieme, Constantin Joachim, additional, Anft, Moritz, additional, Paniskaki, Krystallenia, additional, Doevelaar, Adrian, additional, Seibert, Felix Sebastian, additional, Hoelzer, Bodo, additional, Konik, Margarete Justine, additional, Berger, Marc Moritz, additional, Brenner, Thorsten, additional, Tempfer, Clemens, additional, Watzl, Carsten, additional, Meister, Toni Luise, additional, Pfaender, Stephanie, additional, Steinmann, Eike, additional, Dolff, Sebastian, additional, Dittmer, Ulf, additional, Witzke, Oliver, additional, Stervbo, Ulrik, additional, Roch, Toralf, additional, Or-Guil, Michal, additional, Westhoff, Timm Henning, additional, and Babel, Nina, additional

Published
2022
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46. Mouthrinses against SARS-CoV-2 – High antiviral effectivity by membrane disruption in vitro translates to mild effects in a randomized placebo-controlled clinical trial

Author

Meister, Toni Luise, primary, Gottsauner, Josef-Maximilian, additional, Schmidt, Barbara, additional, Heinen, Natalie, additional, Todt, Daniel, additional, Audebert, Franz, additional, Buder, Felix, additional, Lang, Henriette, additional, Gessner, André, additional, Steinmann, Eike, additional, Vielsmeier, Veronika, additional, Pfaender, Stephanie, additional, and Cieplik, Fabian, additional

Published
2022
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47. Inferior cellular and humoral immunity against Omicron and Delta variants of concern compared with SARS-CoV-2 wild type in hemodialysis patients immunized with 4 SARS-CoV-2 vaccine doses

Author

Anft, Moritz, primary, Blazquez-Navarro, Arturo, additional, Frahnert, Michael, additional, Fricke, Lutz, additional, Meister, Toni L., additional, Roch, Toralf, additional, Stervbo, Ulrik, additional, Pfaender, Stephanie, additional, Westhoff, Timm H., additional, and Babel, Nina, additional

Published
2022
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49. Inactivation of Hepatitis C Virus Infectivity by Human Breast Milk

Author

Pfaender, Stephanie, Heyden, Julia, Friesland, Martina, Ciesek, Sandra, Ejaz, Asim, Steinmann, Joerg, Steinmann, Jochen, Malarski, Angelika, Stoiber, Heribert, Tsiavaliaris, Georgios, Bader, Werner, Jahreis, Gerhard, Pietschmann, Thomas, and Steinmann, Eike

Published
2013

Catalog

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