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4. IGF-I does not affect the net increase in GH release in response to arginine

Author

Nass, Ralf, Pezzoli, Suzan S., Chapman, Ian M., Patrie, James, Hintz, Raymond L., Hartman, Mark L., and Thorner, Michael O.

Subjects
Somatotropin, Insulin-like growth factor 1 -- Physiological aspects, Arginine -- Physiological aspects, Biological sciences
Abstract

Arginine stimulates growth hormone (GH) secretion, possibly by inhibiting hypothalamic somatostatin (SS) release. Insulin-like growth factor I (IGF-I) inhibits GH secretion via effects at the pituitary and/or hypothalamus. We hypothesized that if the dominant action of IGF-I is to suppress GH release at the level of the pituitary, then the arginine-induced net increase in GH concentration would be unaffected by an IGF-I infusion. Eight healthy young adults (3 women, 5 men) were studied on day 2 of a 47-h fast for 12 h (35th-47th h) on four occasions. Saline (Sal) or 10 [micro]g*[kg.sup.-1]*[h.sup.-1] recombinant human IGF-I was infused intravenously for 5 h from 37 to 42 h of the 47-h fast. Arginine (Arg) (30 g iv) or Sal was infused over 30 min during the IGF-I or Sal infusion from 40 to 40.5 h of the fast. Subjects received the following combinations of treatments in random order: 1) Sal + Sal; 2) Sal + Arg; 3) IGF-I + Sal; 4) IGF-I + Arg. Peak GH concentration on the IGF-I + Arg day was ~45% of that on the Sal + Arg day. The effect of arginine on net GH release was calculated as [(Sal + Arg)-(Sal + Sal)]-[(IGF-I + Arg)-(IGF-I + Sal)]. There was no significant effect of IGF-I on net arginine-induced GH release over control conditions. These findings suggest that the negative feedback effect of IGF-I on GH secretion is primarily mediated at the pituitary level and/or at the hypothalamus through a mechanism different from the stimulatory effect of arginine. growth hormone; insulin-like growth factor I

Published
2002

15. Oral Administration of Growth Hormone (GH) Releasing Peptide-Mimetic MK-677 Stimulates the GH/Insulin-Like Growth Factor-I Axis in Selected GH-Deficient Adults1

Author

Chapman, Ian M., primary, Pescovitz, Ora H., additional, Murphy, Gail, additional, Treep, Theresa, additional, Cerchio, Kristine A., additional, Krupa, David, additional, Gertz, Barry, additional, Polvino, William J., additional, Skiles, Emily H., additional, Pezzoli, Suzan S., additional, and Thorner, Michael O., additional

Published
1997
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