40 results on '"Pezzola, D."'
Search Results
2. Efficacy of frovatriptan and other triptans in the treatment of acute migraine of hypertensive and normotensive subjects: a review of randomized studies
- Author
-
Tullo, V., Bussone, G., Omboni, S., Barbanti, P., Cortelli, P., Curone, M., Peccarisi, C., Benedetto, C., Pezzola, D., Zava, D., and Allais, G.
- Published
- 2013
- Full Text
- View/download PDF
3. Frovatriptan vs. other triptans for the acute treatment of oral contraceptive-induced menstrual migraine: pooled analysis of three double-blind, randomized, crossover, multicenter studies
- Author
-
Allais, G., Tullo, V., Omboni, S., Pezzola, D., Zava, D., Benedetto, C., and Bussone, G.
- Published
- 2013
- Full Text
- View/download PDF
4. The economic impact of moderate stage Alzheimer's disease in Italy: Evidence from the UP-TECH randomized trial
- Author
-
Chiatti, C., Furneri, G., Rimland, J. M., Demma, F., Bonfranceschi, F., Cassetta, L., Masera, F. b, Cherubini, Corsonello, A., Lattanzio, F., Baldassarri, D., Bitti, L., Carosi, A., Sabbatini, M., Paolasini, E., Fiori, T., Fronzi, C., Giacchetta, S., Giacomini, V., Giovagnoli, L., Lattanzi, G., Manca, A. M., Marinelli, I., Pigini, V., Pignotti, M., Proietti, M. C., Quarticelli, A., Rovedi, M., Tasso, L., Valeri, V., Antonioli, A., Barabucci, M., Bassani, M., Bollettini, P., Bruttapasta, M. C., Buccolini, C., Carangella, R., Carboni, F., Ceccolini, D., D'Incecco, P., Di Felice, M., Dini, L., Gioia, G., Di Prima, G., Giusepponi, G., Lanciotti, C., Loffreda, A., Luciani, O., Mariani, L., Mastrorilli, F., Moroni, R., Piatkowska, I., Rucoli, R., Scoccia, G., Teodori, N., Tonelli, T., Angeloni, R., Bratti, R. A., Bonafede, G., Lorenzetti, S., Paci, C., Picciotti, G., Pezzola, D., Rea, V., Scialè, V., Signorino, M., Sorvillo, F., Tomassini, P. F., Ciccola, A., Cionfrini, L., Alessandrini, D., De Santis, A., Formica, B., Tacchi, G., Tortorelli, S., Marchegiani, G., Pozzari, G., Santarelli, G., Bartolucci, D., Caraffa, G., Cavallo, Filippo, Di Furia, L., Lacetera, A., Maffei, C. M., Manzoli, L., Postacchini, D., Bevilacqua, R., Bonfigli, A. R., Bustacchini, S., Capasso, M., Civerchia, P., Di Rosa, M., Giuli, C., Marcellini, M., Marinelli, P., Melchiorre, G., Moraca, M. E., Principi, A., Rocchetti, C., Spazzafumo, L., Vincitorio, D., Bartulewicz, K., Olivetti, P., and Rossi, L.
- Subjects
Gerontology ,Male ,very elderly ,cost of illness ,Public expenditure ,morbidity ,residential care ,community care ,Italian (citizen) ,cost analysis ,Surveys and Questionnaires ,Health care ,Activities of Daily Living ,80 and over ,Medicine ,organization and management ,caregiver ,media_common ,Aged, 80 and over ,Public sector ,Mini Mental State Examination ,aged ,Alzheimer disease ,Article ,controlled study ,daily life activity ,disease severity ,economic aspect ,female ,health care ,health care cost ,human ,Italy ,major clinical study ,mortality ,physical performance ,prescription ,prevalence ,randomized controlled trial ,scoring system ,social care ,socioeconomics ,welfare ,economics ,male ,quality of life ,questionnaire ,statistical model, Activities of Daily Living ,Aged ,Alzheimer Disease ,Caregivers ,Cost of Illness ,Female ,Health Expenditures ,Humans ,Linear Models ,Quality of Life ,Alzheimer's disease ,community-living ,RCT ,UP-TECH ,Psychiatry and Mental health ,Clinical Psychology ,Alzheimer’s disease ,media_common.quotation_subject ,Quality of life (healthcare) ,Dementia ,Medical prescription ,Socioeconomic status ,business.industry ,statistical model ,medicine.disease ,Geriatrics and Gerontology ,business ,Welfare - Abstract
Background:There is consensus that dementia is the most burdensome disease for modern societies. Few cost-of-illness studies examined the complexity of Alzheimer's disease (AD) burden, considering at the same time health and social care, cash allowances, informal care, and out-of-pocket expenditure by families.Methods:This is a comprehensive cost-of-illness study based on the baseline data from a randomized controlled trial (UP-TECH) enrolling 438 patients with moderate AD and their primary caregiver living in the community.Results:The societal burden of AD, composed of public, patient, and informal care costs, was about €20,000/yr. Out of this, the cost borne by the public sector was €4,534/yr. The main driver of public cost was the national cash-for-care allowance (€2,324/yr), followed by drug prescriptions (€1,402/yr). Out-of-pocket expenditure predominantly concerned the cost of private care workers. The value of informal care peaked at €13,590/yr. Socioeconomic factors do not influence AD public cost, but do affect the level of out-of-pocket expenditure.Conclusion:The burden of AD reflects the structure of Italian welfare. The families predominantly manage AD patients. The public expenditure is mostly for drugs and cash-for-care benefits. From a State perspective in the short term, the advantage of these care arrangements is clear, compared to the cost of residential care. However, if caregivers are not adequately supported, savings may be soon offset by higher risk of caregiver morbidity and mortality produced by high burden and stress. The study has been registered on the website www.clinicaltrials.org (Trial Registration number: NCT01700556).
- Published
- 2015
5. Socioeconomic Predictors of the Employment of Migrant Care Workers by Italian Families Assisting Older Alzheimer's Disease Patients: Evidence From the Up-Tech Study
- Author
-
Barbabella, F., Chiatti, C., Rimland, J. M., Melchiorre, M. G., Lamura, G., Lattanzio, F., Baldassarri, D., Bitti, L., Carosi, A., Sabbatini, M., Paolasini, E., Fiori, T., Fronzi, C., Giacchetta, S., Giacomini, V., Giovagnoli, L., Lattanzi, G., Manca, A. M., Pigini, V., Pignotti, M., Proietti, M. C., Quarticelli, A., Rovedi, M., Tasso, L., Valeri, V., Antonioli, A., Barabucci, M., Bassani, M., Bollettini, P., Bruttapasta, M. C., Buccolini, C., Carangella, R., Carboni, F., Ceccolini, D., D'Incecco, P., Di Felice, M., Dini, L., Gioia, G., Di Prima, G., Giusepponi, G., Lanciotti, C., Loffreda, A., Luciani, O., Mariani, L., Mastrorilli, F., Moroni, R., Piatkowska, I., Rucoli, R., Scoccia, G., Teodori, N., Tonelli, T., Angeloni, R., Bratti, R. A., Bonafede, G., Lorenzetti, S., Paci, C., Picciotti, G., Pezzola, D., Rea, V., Scialè, V., Signorino, M., Sorvillo, F., Tomassini, P. F., Ciccola, A., Cionfrini, L., Alessandrini, D., De Santis, A., Formica, B., Tacchi, G., Tortorelli, S., Regional, M., Marchegiani, G., Pozzari, G., Santarelli, G., Bartolucci, D., Caraffa, G., Cavallo, Filippo, Di Furia, L., Lacetera, A., Maffei, C. M., Manzoli, L., Postacchini, D., Bonfigli, A. R., Bonfranceschi, F., Bustacchini, S., Capasso, M., Cassetta, L., Civerchia, P., Demma, F., Di Rosa, M., Furneri, G., Giuli, C., Marcellini, M., Marinelli, P., Melchiorre, G., Moraca, M. E., Principi, A., Rocchetti, C., Spazzafumo, L., Vincitorio, D., Bartulewicz, K., Olivetti, P., and Rossi, L.
- Subjects
Gerontology ,Migrant care worker ,Male ,Financing, Government ,very elderly ,aged ,Alzheimer disease ,caregiver ,economics ,educational status ,employment ,female ,financial management ,home care ,human ,Italy ,long term care ,male ,middle aged ,migration ,socioeconomics ,standards ,statistics and numerical data ,supply and distribution ,very elderly, Aged ,Aged, 80 and over ,Alzheimer Disease ,Caregivers ,Educational Status ,Employment ,Female ,Financing, Personal ,Home Care Services ,Humans ,Long-Term Care ,Middle Aged ,Socioeconomic Factors ,Transients and Migrants ,Alzheimer's disease ,Care allowance ,Family caregiver ,Socioeconomic factors ,Up-Tech ,Disease ,0302 clinical medicine ,050602 political science & public administration ,80 and over ,030212 general & internal medicine ,Family caregivers ,05 social sciences ,0506 political science ,Clinical Psychology ,Government ,population characteristics ,Financing ,geographic locations ,Social Psychology ,Social class ,Financial management ,03 medical and health sciences ,medicine ,Personal ,Socioeconomic status ,Aged ,business.industry ,medicine.disease ,Long-term care ,Care workers ,Geriatrics and Gerontology ,business - Abstract
The availability of family caregivers of older people is decreasing in Italy as the number of migrant care workers (MCWs) hired by families increases. There is little evidence on the influence of socioeconomic factors in the employment of MCWs.We analyzed baseline data from 438 older people with moderate Alzheimer's disease (AD), and their family caregivers enrolled in the Up-Tech trial. We used bivariate analysis and multilevel regressions to investigate the association between independent variables-education, social class, and the availability of a care allowance-and three outcomes-employment of a MCW, hours of care provided by the primary family caregiver, and by the family network (primary and other family caregivers).The availability of a care allowance and the educational level were independently associated with employing MCWs. A significant interaction between education and care allowance was found, suggesting that more educated families are more likely to spend the care allowance to hire a MCW.Socioeconomic inequalities negatively influenced access both to private care and to care allowance, leading disadvantaged families to directly provide more assistance to AD patients. Care allowance entitlement needs to be reformed in Italy and in countries with similar long-term care and migration systems.
- Published
- 2014
6. Tracheostomy in Patients with Respiratory Failure Receiving Mechanical Ventilation: How, when, and for whom?
- Author
-
Apezteguia, C., primary, Ríos, F., additional, and Pezzola, D., additional
- Full Text
- View/download PDF
7. Dexketoprofen trometamol in the acute treatment of migraine attack: A phase II, randomized, double-blind, crossover, placebo-controlled, dose optimization study
- Author
-
Mainardi, F., primary, Maggioni, F., additional, Pezzola, D., additional, Zava, D., additional, and Zanchin, G., additional
- Published
- 2013
- Full Text
- View/download PDF
8. Significato e importanza dei rilievi manometrici nell'acalasia esofagea
- Author
-
Missale, Guido, Pezzola, D., and Lojacono, L.
- Published
- 1985
9. L'endoscopia nella malattia diverticolare del colon. Validità diagnostica nella nostra esperienza
- Author
-
Cestari, Renzo, Braga, M., Missale, Guido, Pezzola, D., and Ravelli, P.
- Published
- 1986
10. La malattia diverticolare del colon: indicazioni e trattamento chirurgico in urgenza e in elezione. (Nostra esperienza)
- Author
-
Braga, M., Casella, Claudio, Pezzola, D., Farfaglia, R., and Lojacono, L.
- Published
- 1989
11. Immunoscintigrafia dei carcinomi colo-rettali con anticorpi marcati anti-CEA e anti-CA 19-9
- Author
-
Pezzola, D., Farfaglia, R., Tonni, M. P., Tonini, G., Missale, Guido, Guerra, Up, and Terzi, A.
- Published
- 1987
12. L'endoscopia nel follow-up dei pazienti operati per neoplasia colo-rettale
- Author
-
Cestari, Renzo, Pezzola, D., Missale, Guido, and Ravelli, P.
- Published
- 1986
13. Il cancro del retto nei pazienti ad alto rischio: trattamento locale
- Author
-
Pezzola, D., Ravelli, P., Missale, Guido, Zappella, A., and Cestari, Renzo
- Published
- 1989
14. La colecistectomia associata ad altri interventi di chirurgia addominale: rischio aumentato?
- Author
-
DE NOBILI, Umberto, Mittempergher, F., Farfaglia, R., Missale, Guido, and Pezzola, D.
- Published
- 1986
15. Il trattamento dell'early gastric cancer nella nostra esperienza. Risultati a distanza
- Author
-
Cestari, Renzo, Pezzola, D., Terraroli, C., Braga, M., Missale, Guido, Tonini, G., and Lojacono, L.
- Published
- 1987
16. Early gastric cancer: correlazioni endoscopico-anatomopatologiche in 39 casi
- Author
-
Cestari, Renzo, Missale, Guido, Pezzola, D., Braga, M., Lojacono, L., Zorzi, F., and Baronchelli, C.
- Published
- 1985
17. Il trattamento endoscopico delle stenosi esofagee benigne: indicazioni, tecnica e risultati (esperienza personale)
- Author
-
Cestari, Renzo, Ravelli, P., Missale, Guido, Lancini, P., Braga, M., and Pezzola, D.
- Published
- 1988
18. La nostra esperienza sull'impiego della ranitidina nelle emorragie gastroduodenali
- Author
-
Cestari, Renzo, Missale, Guido, Pezzola, D., Salerni, Bruno, and Lojacono, L.
- Published
- 1984
19. Heavy Metals Slow Release from Retained Lead Projectiles and Thermometer's Mercury
- Author
-
Giampreti, A., Lonati, D., Bigi, S., Vecchio, S., Locatelli, C., valeria margherita petrolini, Manzo, L., Pellicciotti, A., and Pezzola, D.
20. Comparison of frovatriptan plus dexketoprofen (25 mg or 37.5 mg) with frovatriptan alone in the treatment of migraine attacks with or without aura: a randomized study
- Author
-
Giuliano Sette, Marcella Curone, Fabio Frediani, Florindo d’Onofrio, Deborha Pezzola, Gianni Allais, Dario Zava, Piero Barbanti, Pietro Cortelli, Fabio Valguarnera, Vincenzo Tullo, Chiara Benedetto, Gennaro Bussone, Tullo, V., Valguarnera, F., Barbanti, P., Cortelli, P., Sette, G., Allais, G., D'Onofrio, F., Curone, M., Zava, D., Pezzola, D., Benedetto, C., Frediani, F., and Bussone, G.
- Subjects
Male ,Photophobia ,NSAIDs ,Triptans ,Migraine Disorder ,Drug Combination ,triptan ,Tromethamine ,skin and connective tissue diseases ,Analgesics ,education.field_of_study ,Frovatriptan ,Dexketoprofen ,Migraine attacks ,Anti-Inflammatory Agents, Non-Steroidal ,General Medicine ,Middle Aged ,NSAID ,Tryptamines ,Serotonin Receptor Agonists ,Drug Combinations ,Phonophobia ,Ketoprofen ,Anesthesia ,Female ,medicine.symptom ,Human ,medicine.drug ,Adult ,Nausea ,Migraine Disorders ,Population ,Carbazole ,Carbazoles ,migraine attack ,digestive system ,Double-Blind Method ,medicine ,Humans ,education ,business.industry ,medicine.disease ,digestive system diseases ,Migraine ,Serotonin Receptor Agonist ,Analgesic ,Neurology (clinical) ,business - Abstract
Background Drugs for migraine attacks include triptans and NSAIDs; their combination could provide greater symptom relief. Methods A total of 314 subjects with history of migraine, with or without aura, were randomized to frovatriptan 2.5 mg alone (Frova), frovatriptan 2.5 mg + dexketoprofen 25 mg (FroDex25) or frovatriptan 2.5 mg + dexketoprofen 37.5 mg (FroDex37.5) and treated at least one migraine attack. This was a multicenter, randomized, double-blind, parallel-group study. The primary end point was the proportion of pain free (PF) at two hours. Secondary end points were PF at one and four hours, pain relief (PR) at one, two, four hours, sustained PF (SPF) at 24 and 48 hours, recurrence at 48 hours, resolution of nausea, photophobia and phonophobia at two and four hours, the use of rescue medication and the judgment of the treatment. Results The results were assessed in the full analysis set (FAS) population, which included all subjects randomized and treated for whom at least one post-dose intensity of headache was recorded. The proportions of subjects PF at two hours (primary end point) were 29% (27/93) with Frova compared with 51% (48/95 FroDex25 and 46/91 FroDex37.5) with each combination therapies ( p Conclusion FroDex improved initial efficacy at two hours compared to Frova whilst maintaining efficacy at 48 hours in this study. Tolerability profiles were comparable. Intrinsic pharmacokinetic properties of the two single drugs contribute to this improved efficacy profile.
- Published
- 2014
21. Efficacy of early vs. late use of frovatriptan combined with dexketoprofen vs. frovatriptan alone in the acute treatment of migraine attacks with or without aura
- Author
-
Marcella Curone, Piero Barbanti, Giorgio Reggiardo, Gianni Allais, Dario Zava, Stefano Omboni, Florindo d’Onofrio, Giuliano Sette, Pietro Cortelli, Fabio Valguarnera, Vincenzo Tullo, Fabio Frediani, Chiara Benedetto, Gennaro Bussone, Deborha Pezzola, Allais, G., Tullo, V., Cortelli, P., Barbanti, P., Valguarnera, F., Sette, G., D'Onofrio, F., Curone, M., Zava, D., Pezzola, D., Reggiardo, G., Omboni, S., Frediani, F., Bussone, G., and Benedetto, C.
- Subjects
Male ,Migraine without Aura ,Time Factors ,Aura ,Migraine with Aura ,Pilot Projects ,Tryptamine ,law.invention ,Randomized controlled trial ,law ,Medicine ,Migraine ,Frovatriptan ,Dexketoprofen ,Early intake ,Late intake ,Tromethamine ,Anti-Inflammatory Agents, Non-Steroidal ,General Medicine ,Middle Aged ,Tryptamines ,Serotonin Receptor Agonists ,Psychiatry and Mental health ,Treatment Outcome ,Ketoprofen ,Anesthesia ,Drug Therapy, Combination ,Female ,medicine.symptom ,Human ,medicine.drug ,Adult ,Adolescent ,Time Factor ,Carbazoles ,Carbazole ,Clinical Neurology ,Dermatology ,Young Adult ,Pharmacotherapy ,Double-Blind Method ,Post-hoc analysis ,Humans ,Pain Management ,Pilot Project ,Aged ,SYMPOSIUM Migraine and its varieties ,business.industry ,medicine.disease ,Migraine with aura ,Serotonin Receptor Agonist ,Neurology (clinical) ,business - Abstract
Early triptan use after headache onset may help improve the efficacy of acute migraine treatment. This may be particularly the case when triptan therapy is combined with a nonsteroidal anti-inflammatory drug (NSAID). The objective of this is to assess whether the combination of frovatriptan 2.5 mg + dexketoprofen 25 or 37.5 mg (FroDex25 and FroDex37.5) is superior to frovatriptan 2.5 mg alone (Frova) in the acute treatment of migraine attacks in patients who took the drug within 30 min from the onset of pain (early use) or after (late use). A total of 314 subjects with a history of migraine with or without aura were randomized into a double-blind, multicenter, parallel group, pilot study to Frova, FroDex25 or FroDex37.5 and were required to treat at least one migraine attack. In the present post hoc analysis, traditional migraine endpoints were compared across study drugs for subgroups of the 279 patients of the full analysis set according to early (n = 172) or late (n = 107) drug use. The proportion of patients pain free at 2 h in the early drug use subgroup was 33 % with Frova, 50 % with FroDex25 and 51 % with FroDex37.5 mg (p = NS combinations vs. monotherapy), while in the late drug use subgroup was 22, 51 and 50 % (p
- Full Text
- View/download PDF
22. Pulsed Radiofrequency Application on Femoral and Obturator Nerves for Hip Joint Pain: Retrospective Analysis with 12-Month Follow-up Results.
- Author
-
Tinnirello A, Todeschini M, Pezzola D, and Barbieri S
- Subjects
- Aged, Denervation methods, Female, Femoral Nerve radiation effects, Follow-Up Studies, Hip Joint radiation effects, Humans, Male, Middle Aged, Obturator Nerve radiation effects, Retrospective Studies, Osteoarthritis, Hip therapy, Pain Management methods, Pulsed Radiofrequency Treatment methods
- Abstract
Background: Osteoarthritis of the hip joint is a common cause of pain and disability. Patients not responding to conservative management often cannot undergo joint replacement due to the presence of multiple comorbidities, while some other patients prefer to postpone surgery as long as possible. Radiofrequency denervation of articular branches of the femoral and obturator nerves, which supply innervation of the joint, is a novel technique to reduce hip joint pain. Previous studies reported positive results after application of continuous radiofrequency to the target nerves; however, this approach carries the potential risk of neuritis and neuroma formation. Pulsed radiofrequency (PRF) is a safer alternative to continuous radiofrequency not creating necrosis but a complex neuromodulatory effect on target nerves. There is no published evidence of PRF efficacy after 3 month follow-up., Objectives: This single-center study objective was to evaluate the short and medium term effectiveness of PRF on the femoral articular branches and obturator nerves in patients with chronic hip pain., Study Design: Retrospective single-center study., Setting: Italian National Health Service Public Hospital., Methods: Retrospective analysis of 14 patients treated with PRF for severe hip joint pain (mean numericAL rating scale (NRS) 7.7 ± 1.2 mean Oxford Hip Score (OHS) 20 ± 8.4). Mean pain and disability scores were evaluated with NRS and OHS respectively at 1, 3, 6 and 12-month follow-up. Mean pain and disability scores were evaluated with NRS and OHS respectively at 1, 3, 6, and 12-month follow-up. All patients were treated with pulsed radiofrequency applied under fluoroscopy on the articular branches of the femoral and obturator nerves for 300 seconds each., Results: Eight patients out of 14 (57%) reported an NRS reduction > 50% at 1 month post procedure. Overall, both pain and disability scores were significantly (P < 0.01) lower at all follow-up until 6 months, mean NRS at 1, 3, and 6 months was 3.6 ± 3; 4.1 ± 3.3; 4.8 ± 2.9 while OHS was 37.6 ± 17.7; 35.8 ± 17.7; 35.8 ± 14 respectively. At 12 months, NRS was 5.8 ± 2.4 while OHS 23.3 ± 12.7, it must be pointed out that even if both scores are significantly (P < 0.01) lower than basal, only 3 patients out of 14 (21%) maintained a NRS reduction > 50% from basal at 12 months post procedure. We reported 2 femoral artery punctures without any significant complication., Limitations: Retrospective study, small sample size., Conclusions: Pulsed radiofrequency is a safe and effective modality to treat hip joint pain in the short and medium term. Definition of positive outcome predictors is required to reserve radiofrequency treatment only for those patients who can benefit from this procedure., Key Words: Hip joint pain, pulsed radiofrequency, obturator nerve, femoral nerve, interventional pain management, radiofrequency.
- Published
- 2018
23. Comparison of frovatriptan plus dexketoprofen (25 mg or 37.5 mg) with frovatriptan alone in the treatment of migraine attacks with or without aura: a randomized study.
- Author
-
Tullo V, Valguarnera F, Barbanti P, Cortelli P, Sette G, Allais G, d'Onofrio F, Curone M, Zava D, Pezzola D, Benedetto C, Frediani F, and Bussone G
- Subjects
- Adult, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Double-Blind Method, Drug Combinations, Female, Humans, Ketoprofen administration & dosage, Male, Middle Aged, Serotonin Receptor Agonists administration & dosage, Analgesics administration & dosage, Carbazoles administration & dosage, Ketoprofen analogs & derivatives, Migraine Disorders drug therapy, Tromethamine administration & dosage, Tryptamines administration & dosage
- Abstract
Background: Drugs for migraine attacks include triptans and NSAIDs; their combination could provide greater symptom relief., Methods: A total of 314 subjects with history of migraine, with or without aura, were randomized to frovatriptan 2.5 mg alone (Frova), frovatriptan 2.5 mg + dexketoprofen 25 mg (FroDex25) or frovatriptan 2.5 mg + dexketoprofen 37.5 mg (FroDex37.5) and treated at least one migraine attack. This was a multicenter, randomized, double-blind, parallel-group study. The primary end point was the proportion of pain free (PF) at two hours. Secondary end points were PF at one and four hours, pain relief (PR) at one, two, four hours, sustained PF (SPF) at 24 and 48 hours, recurrence at 48 hours, resolution of nausea, photophobia and phonophobia at two and four hours, the use of rescue medication and the judgment of the treatment., Results: The results were assessed in the full analysis set (FAS) population, which included all subjects randomized and treated for whom at least one post-dose intensity of headache was recorded. The proportions of subjects PF at two hours (primary end point) were 29% (27/93) with Frova compared with 51% (48/95 FroDex25 and 46/91 FroDex37.5) with each combination therapies ( P < 0.05). Proportions of SPF at 24 hours were 24% (22/93) for Frova, 43% (41/95) for FroDex25 ( P < 0.001) and 42% (38/91) for FroDex37.5 ( P < 0.05). SPF at 48 hours was 23% (21/93) with Frova, 36% (34/95) with FroDex25 and 33% (30/91) with FroDex37.5 ( P = NS). Recurrence was similar for Frova (22%, 6/27), FroDex25 (29%, 14/48) and FroDex37.5 (28%, 13/46) ( P = NS), meaning a lack of improvement with the combination therapy. Statistical adjustment for multiple comparisons was not performed. No statistically significant differences were reported in the occurrence of total and drug-related adverse events. FroDex25 and FroDex37.5 showed a similar efficacy both for primary and secondary end points. There did not seem to be a dose response curve for the addition of dexketoprofen., Conclusion: FroDex improved initial efficacy at two hours compared to Frova whilst maintaining efficacy at 48 hours in this study. Tolerability profiles were comparable. Intrinsic pharmacokinetic properties of the two single drugs contribute to this improved efficacy profile.
- Published
- 2014
- Full Text
- View/download PDF
24. Efficacy of frovatriptan and other triptans in the treatment of acute migraine of normal weight and obese subjects: a review of randomized studies.
- Author
-
Saracco MG, Allais G, Tullo V, Zava D, Pezzola D, Reggiardo G, Omboni S, Benedetto C, Bussone G, and Aguggia M
- Subjects
- Humans, Randomized Controlled Trials as Topic, Carbazoles therapeutic use, Migraine Disorders drug therapy, Migraine Disorders physiopathology, Obesity physiopathology, Serotonin Receptor Agonists therapeutic use, Tryptamines therapeutic use
- Abstract
An association between obesity and migraine has been observed in recent studies and it is supported by plausible biological mechanisms. The objective of this study is to evaluate the efficacy of frovatriptan and other triptans in the acute treatment of migraine, in patients enrolled in three randomized, double-blind, crossover, Italian studies and classified according to body mass index (BMI) levels, as normal weight or non-obese (NO, BMI 18.5-24.9 kg/m(2)) and overweight or obese subjects (O, BMI ≥ 25 kg/m(2)). 414 migraineurs with or without aura were randomized to frovatriptan 2.5 mg or rizatriptan 10 mg (study 1), frovatriptan 2.5 mg or zolmitriptan 2.5 mg (study 2), frovatriptan 2.5 mg or almotriptan 12.5 mg (study 3). After treating up to three episodes of migraine in 3 months with the first treatment, patients switched to the alternate treatment for the next 3 months. The present analysis assessed triptan efficacy in 220 N and in 109 O subjects of the 346 individuals of the intention-to-treat population. The proportion of pain free at 2 h did not significantly differ between frovatriptan and the comparators in either NO (30 vs. 34 %) or O (24 vs. 27 %). However, the rate of pain free at 2 h was significantly (p < 0.05) larger in NO than in O, irrespective of the type of triptan. Pain relief at 2 h was also similar between drug treatments for either subgroup. Pain relapse occurred at 48 h in significantly (p < 0.05) fewer episodes treated with frovatriptan in both NO (26 vs. 36 %) and O (27 vs. 49 %). The rate of 48-h relapse was similar in NO and O with frovatriptan, while it was significantly (p < 0.05) higher in O with the comparators. Frovatriptan, in contrast to other triptans, retains a sustained antimigraine effect in NO and even more so in O subjects.
- Published
- 2014
- Full Text
- View/download PDF
25. Efficacy of early vs. late use of frovatriptan combined with dexketoprofen vs. frovatriptan alone in the acute treatment of migraine attacks with or without aura.
- Author
-
Allais G, Tullo V, Cortelli P, Barbanti P, Valguarnera F, Sette G, D'Onofrio F, Curone M, Zava D, Pezzola D, Reggiardo G, Omboni S, Frediani F, Bussone G, and Benedetto C
- Subjects
- Adolescent, Adult, Aged, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Ketoprofen therapeutic use, Male, Middle Aged, Pain Management methods, Pilot Projects, Time Factors, Treatment Outcome, Young Adult, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Carbazoles therapeutic use, Ketoprofen analogs & derivatives, Migraine with Aura drug therapy, Migraine without Aura drug therapy, Serotonin Receptor Agonists therapeutic use, Tromethamine therapeutic use, Tryptamines therapeutic use
- Abstract
Early triptan use after headache onset may help improve the efficacy of acute migraine treatment. This may be particularly the case when triptan therapy is combined with a nonsteroidal anti-inflammatory drug (NSAID). The objective of this is to assess whether the combination of frovatriptan 2.5 mg + dexketoprofen 25 or 37.5 mg (FroDex25 and FroDex37.5) is superior to frovatriptan 2.5 mg alone (Frova) in the acute treatment of migraine attacks in patients who took the drug within 30 min from the onset of pain (early use) or after (late use). A total of 314 subjects with a history of migraine with or without aura were randomized into a double-blind, multicenter, parallel group, pilot study to Frova, FroDex25 or FroDex37.5 and were required to treat at least one migraine attack. In the present post hoc analysis, traditional migraine endpoints were compared across study drugs for subgroups of the 279 patients of the full analysis set according to early (n = 172) or late (n = 107) drug use. The proportion of patients pain free at 2 h in the early drug use subgroup was 33 % with Frova, 50 % with FroDex25 and 51 % with FroDex37.5 mg (p = NS combinations vs. monotherapy), while in the late drug use subgroup was 22, 51 and 50 % (p < 0.05 FroDex25 and FroDex37.5 vs. Frova), respectively. Pain-free episodes at 4 h were 54 % for early and 34 % for late use of Frova, 71 and 57 % with FroDex25 and 74 and 68 % with FroDex37.5 (p < 0.05 for early and p < 0.01 for late use vs. Frova). The proportion of sustained pain free at 24 h was 26 % under Frova, 43 % under FroDex25 mg and 40 % under FroDex37.5 mg (p = NS FroDex25 or 37.5 vs. Frova) in the early drug intake subgroup, while it was 19 % under Frova, 43 % under FroDex25 mg and 45 % under FroDex37.5 mg (p < 0.05 FroDex25 and FroDex37.5 vs. Frova) in the late drug intake subgroup. Risk of relapse at 48 h was similar (p = NS) among study drug groups (Frova: 25 %, FroDex25: 21 %, and FroDex37.5: 37 %) for the early as well as for the late drug use subgroup (14, 42 and 32 %). FroDex was found to be more effective than Frova taken either early or late. The intrinsic pharmacokinetic properties of the two single drug components made FroDex combination particularly effective within the 2-48-h window from the onset of the acute migraine attack. The efficacy does not seem to be influenced by the time of drug use relative to the onset of headache.
- Published
- 2014
- Full Text
- View/download PDF
26. Dexketoprofen trometamol in the acute treatment of migraine attack: a phase II, randomized, double-blind, crossover, placebo-controlled, dose optimization study.
- Author
-
Mainardi F, Maggioni F, Pezzola D, Zava D, and Zanchin G
- Subjects
- Adult, Cross-Over Studies, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Ketoprofen administration & dosage, Male, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Ketoprofen analogs & derivatives, Migraine Disorders drug therapy, Tromethamine administration & dosage
- Abstract
Unlabelled: Migraine is a disabling disease that can significantly affect a person's quality of life. This study assessed the efficacy and tolerability of the 2 doses of dexketoprofen trometamol (DKP) compared to placebo for migraine treatment. Ninety-three patients with at least 1 migraine attack per month in the preceding 6 months were enrolled and randomized to 25 mg DKP, 50 mg DKP, and placebo in a randomized, double-blind, single-center, crossover, placebo-controlled study. Primary endpoint was pain-free episodes 2 hours after drug intake. The presence of accompanying symptoms and adverse effects was also recorded. Seventy-six patients (mean age 40.5 ± 10.9 and 61% female) completed the study. At baseline, mean number of attacks/month was 3.7 ± 1.3, with a mean duration of 15.4 ± 13.5 hours. Prevalence of pain-free episodes after drug intake was significantly reduced by 50 mg DKP vs placebo (33.8 vs 14.7%, P = .0065) whereas the dose of DKP 25 mg was better than placebo but did not reach statistical significance (23 vs 14.7%, P = .1182). Both 25 mg DKP (56.8 vs 25.3%, P = .0002) and 50 mg DKP improved headache relief compared to placebo. Furthermore, both doses of DKP increased the absence of functional disability (25 mg DKP, 39.7 vs 24%, P = .045; and 50 mg DKP, 45.9 vs 24%, P < .0004). Both doses of DKP were effective and well tolerated for acute migraine treatment., Perspective: This article demonstrates the efficacy and tolerability of DKP in the treatment of migraine without and with aura attacks. Its rapid absorption rate with higher maximum plasma concentrations and shorter time to maximum values suggest that this drug is a good option for acute migraine treatment., (Copyright © 2014 American Pain Society. Published by Elsevier Inc. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
27. Lung function and organ dysfunctions in 178 patients requiring mechanical ventilation during the 2009 influenza A (H1N1) pandemic.
- Author
-
Ríos FG, Estenssoro E, Villarejo F, Valentini R, Aguilar L, Pezzola D, Valdez P, Blasco M, Orlandi C, Alvarez J, Saldarini F, Gómez A, Gómez PE, Deheza M, Zazu A, Quinteros M, Chena A, Osatnik J, Violi D, Gonzalez ME, and Chiappero G
- Subjects
- Adult, Argentina epidemiology, Cohort Studies, Female, Hospital Mortality, Humans, Influenza, Human virology, Intensive Care Units, Male, Middle Aged, Multiple Organ Failure physiopathology, Pneumonia mortality, Pneumonia physiopathology, Prospective Studies, Real-Time Polymerase Chain Reaction, Respiratory Function Tests, Survival Analysis, Influenza A Virus, H1N1 Subtype isolation & purification, Influenza, Human epidemiology, Influenza, Human physiopathology, Lung physiopathology, Multiple Organ Failure epidemiology, Pneumonia virology, Respiration, Artificial
- Abstract
Introduction: Most cases of the 2009 influenza A (H1N1) infection are self-limited, but occasionally the disease evolves to a severe condition needing hospitalization. Here we describe the evolution of the respiratory compromise, ventilatory management and laboratory variables of patients with diffuse viral pneumonitis caused by pandemic 2009 influenza A (H1N1) admitted to the ICU., Method: This was a multicenter, prospective inception cohort study including adult patients with acute respiratory failure requiring mechanical ventilation (MV) admitted to 20 ICUs in Argentina between June and September of 2009 during the influenza A (H1N1) pandemic. In a standard case-report form, we collected epidemiological characteristics, results of real-time reverse-transcriptase--polymerase-chain-reaction viral diagnostic tests, oxygenation variables, acid-base status, respiratory mechanics, ventilation management and laboratory tests. Variables were recorded on ICU admission and at days 3, 7 and 10., Results: During the study period 178 patients with diffuse viral pneumonitis requiring MV were admitted. They were 44 ± 15 years of age, with Acute Physiology And Chronic Health Evaluation II (APACHE II) scores of 18 ± 7, and most frequent comorbidities were obesity (26%), previous respiratory disease (24%) and immunosuppression (16%). Non-invasive ventilation (NIV) was applied in 49 (28%) patients on admission, but 94% were later intubated.Acute respiratory distress syndrome (ARDS) was present throughout the entire ICU stay in the whole group (mean PaO2/FIO2 170 ± 25). Tidal-volumes used were 7.8 to 8.1 ml/kg (ideal body weight), plateau pressures always remained < 30 cmH2O, without differences between survivors and non-survivors; and mean positive end-expiratory pressure (PEEP) levels used were between 8 to 12 cm H2O. Rescue therapies, like recruitment maneuvers (8 to 35%), prone positioning (12 to 24%) and tracheal gas insufflation (3%) were frequently applied. At all time points, pH, platelet count, lactate dehydrogenase assay (LDH) and Sequential Organ Failure Assessment (SOFA) differed significantly between survivors and non-survivors. Lack of recovery of platelet count and persistence of leukocytosis were characteristic of non-survivors. Mortality was high (46%); and length of MV was 10 (6 to 17) days., Conclusions: These patients had severe, hypoxemic respiratory failure compatible with ARDS that persisted over time, frequently requiring rescue therapies to support oxygenation. NIV use is not warranted, given its high failure rate. Death and evolution to prolonged mechanical ventilation were common outcomes. Persistence of thrombocytopenia, acidosis and leukocytosis, and high LDH levels found in non-survivors during the course of the disease might be novel prognostic findings.
- Published
- 2011
- Full Text
- View/download PDF
28. [The role of intraoperative parathyroid hormone assay in the surgical management of hyperparathyroidism].
- Author
-
Balzano R, Camoni G, Lazzari L, Pezzola D, Farfaglia R, Cappelli C, and Braga M
- Subjects
- Adenoma diagnosis, Aged, Carcinoma, Papillary surgery, Diagnosis, Differential, Female, Follow-Up Studies, Goiter, Nodular surgery, Humans, Hyperparathyroidism blood, Hyperparathyroidism diagnosis, Immunoenzyme Techniques, Intraoperative Care, Luminescent Measurements, Male, Parathyroid Neoplasms diagnosis, Thyroid Neoplasms surgery, Thyroidectomy, Time Factors, Adenoma surgery, Hyperparathyroidism surgery, Parathyroid Hormone blood, Parathyroid Neoplasms surgery
- Abstract
Surgical management of primary hyperparathyroidism has undergone several chances in recent years and historically has required bilateral neck exploration with identification of the parathyroid adenoma together with three normal glands. The intraoperative hormone assay allows a more limited procedure by confirming complete removal of hypersecreting tissue. The Authors report surgical treatment of 24 consecutive hyperparathyroidism and conclude that evaluation of intraoperative hormone assay accurately predicts the determination of adequacy of resection and the correct outcome of surgery in patients with parathyroid adenomas.
- Published
- 2004
29. [Impact of a screening program on the surgical treatment of breast carcinoma].
- Author
-
Braga M, Pinelli D, Filippini L, Ragni F, Piccini PI, Pezzola D, Bianchi AM, and Perna E
- Subjects
- Age Factors, Aged, Biopsy, Breast pathology, Breast Neoplasms pathology, Female, Humans, Italy, Lymph Node Excision, Lymphatic Metastasis, Mammography, Mastectomy, Mastectomy, Modified Radical, Mastectomy, Radical, Mastectomy, Segmental, Middle Aged, Breast Neoplasms prevention & control, Breast Neoplasms surgery, Mass Screening
- Abstract
Results are presented concerning the first two cycles of a breast cancer screening program carried out by USSL 41 (the local social health center). 38,000 women were examined in a period ranging from 1987 to 1993 and more than 250 early stage tumors were diagnosed. Early detection by screening is confirmed by tumor size and nodal involvement. Overall, this program carried out in Brescia met requirements set by international and national scientific committees. Good results were obtained as far as quality standards are concerned. The importance of screening is evaluated concerning surgical treatment undergone by the patients. The study of surgical treatment clearly shows the gradual progression of conservative surgery deviating from more destructive operations.
- Published
- 1996
30. [Agenesis of the retrohepatic segment of the inferior vena cava: a case].
- Author
-
Balzano R, Pezzola D, Farfaglia R, Braga M, Ragni F, Pinelli D, Grazioli L, and Mutascio B
- Subjects
- Adult, Female, Humans, Liver, Vena Cava, Inferior abnormalities
- Published
- 1996
31. [Intestinal anastomosis with biodegradable ring].
- Author
-
Ragni F, Braga M, Balzano R, Piccini I, Pezzola D, Pinelli D, Pasini M, Roncali S, Ghedi M, and Damiani E
- Subjects
- Adult, Aged, Aged, 80 and over, Anastomosis, Surgical instrumentation, Biodegradation, Environmental, Female, Humans, Intestinal Diseases complications, Male, Middle Aged, Postoperative Complications, Treatment Outcome, Intestinal Diseases surgery, Intestines surgery
- Abstract
The authors report their experience using biofragmentable anastomosis ring (BAR) in bowel anastomosis. Starting January 1993 to February 1994, 46 intestinal anastomoses were performed using BAR, and particularly 39 end-to-end colo-colostomies, 2 end-to-side colo-colostomies and 5 end-to-side ileo-colostomies. 35 patients were affected by colonic neoplasm, 5 patients by diverticular colonic complications- and 5 patients by several unusual bowel diseases. Four emergency operations were performed, while 42 patients had an accurate bowel preparation before surgery. In this series of patients one case of preoperative mortality is reported, due to massive pulmonary embolism. Instead several minor complications occurred in other patients, such as paroxysmal atrial fibrillation (one case), basal pleuritis (one case), hyperpyrexia (three cases), temporary subocclusion or delayed canalization (five cases). Only one patient suffered from intestinal occlusion induced by adhesions and a second laparotomy was required. Delayed canalization seems to be caused by the small size of the BAR employed (25 mm) or by inadequate intestinal preparation, that usually occurs in emergency operations. After surgery all patients were followed up and 18 of them were examined by coloscopy six months after surgery. No clinical problem connected with bowel anastomosis was reported and all anastomosis looked quite previous and resilient. No anastomotic stenosis was found. In our experience and from recent reviewed reports, BAR seems to be a rapid, effective and safe device for sutureless bowel anastomosis.
- Published
- 1996
32. [Solitary splenic metastasis of bladder carcinoma. Report of a clinical case].
- Author
-
Vittoria A, Pinelli D, Pezzola D, Filippini L, Vaiana R, Bianchi A, Ghedi M, and Camoni G
- Subjects
- Aged, Humans, Male, Carcinoma, Transitional Cell secondary, Splenic Neoplasms secondary, Urinary Bladder Neoplasms pathology
- Abstract
Several authors assumed that spleen was resistant to neoplastic dissemination because of spleen metastasis are rare in relation to the incidence of metastasis in other parenchymatous organs. We report a clinical case of a symptomatic solitary spleen metastasis in cystic-looking bladder cancer; afterwards we'll examine real incidence of secondary splenic injury. In autopsy studies, the incidence of splenic metastatic spread is in contrast with the rarity of clinical manifestations of solitary metastasis. The case reported is really uncommon: a voluminous single metastasis, cystic-looking, with splenomegaly, abdominal pain and rapid onset. In the presence of a high malignancy primitive tumor, the evaluation of the effective utility of the surgical treatment carried out is premature, because of the relatively short follow-up. On the other hand, the painful symptomatology, the risk of disruption in peritoneal cavity, the impossibility to make inquiries about the nature of the cystic mass, imposed, in our opinion, a surgical treatment.
- Published
- 1996
33. Results of a mammographic and clinical screening in a health district (USSL) of Brescia, Italy.
- Author
-
Filippini L, Braga M, Perna E, Bianchi AM, Bettoni C, Lucini L, Pezzola D, Pinelli D, Tonini G, Tonini G, and Callea F
- Subjects
- Axilla, Breast Neoplasms pathology, Breast Neoplasms surgery, Female, Humans, Italy, Lymphatic Metastasis, Mass Screening methods, Mastectomy, Middle Aged, Breast Neoplasms diagnostic imaging, Mammography statistics & numerical data, Mass Screening statistics & numerical data
- Abstract
Aims and Background: Screening by mammography has been shown to be effective in reducing breast cancer mortality. We present the results of a mammographic and clinical screening program carried out in an Italian health district., Methods: The first screening round started in June 1987 and ended in July 1990, and 25,100 women between the age of 50 and 60 years were invited. The second screening round invited 34,332 women between the age of 50 and 64 years and was carried out from September 1990 to September 1993. Women with positive or equivocal results at palpation or mammography were referred for immediate diagnostic assessment followed by surgery, when required., Results: The attendance rate was 67.3% at the first and 62.1% at the repeat screening. At the first screening, 206 biopsies were advised and 197 were performed; 129 of the 197 were found to be malignant. At repeat screening, 248 biopsies were recommended, 208 were performed, and 125 were found to be malignant. The cancer detection rate was 7.7 per thousand at the first and 5.9 per thousand at repeat screening. Of 129 cancers, 107 (83.0%) were T1 at first screening; 6.2% were in situ carcinomas. Axillary lymph nodes were histologically positive in 24% of cases. At repeat screening, 77.6% (97/125) of cancers were T1; 11.2% were in situ carcinomas. Positive axillary lymph nodes were found in 16.8% of cases., Conclusions: The attendance to screening was satisfactory. A higher frequency of small tumors (83.0%) was found at first screening than before the introduction of screening (56.6%). A marked difference in lymph node positivity (24.0% vs 40.6% in the pre-screening era) was also observed. Such a difference was even more evident at repeat screening. Quality standards of the screening in our study proved to be higher than those currently recommended. The reported results are encouraging, also considering the greater chance for conservative treatment.
- Published
- 1996
- Full Text
- View/download PDF
34. [Thyroid carcinoma in hyperthyroid syndromes].
- Author
-
Ragni F, Pinelli D, Facchini M, Ghedi M, Piccini I, Pasini M, Roncali S, Pezzola D, and Braga M
- Subjects
- Adenocarcinoma, Follicular etiology, Adult, Carcinoma, Papillary etiology, Disease-Free Survival, Female, Graves Disease complications, Graves Disease surgery, Humans, Hyperthyroidism complications, Middle Aged, Syndrome, Thyroid Neoplasms etiology, Thyroidectomy, Adenocarcinoma, Follicular surgery, Carcinoma, Papillary surgery, Hyperthyroidism surgery, Thyroid Neoplasms surgery
- Abstract
The relationship between hyperthyroidism and carcinoma of the thyroid is still uncertain. The incidence of thyroid carcinoma ranges from 0.3 to 16.6%. Between 1984 and 1994 the Authors observed 9 patients affected with thyroid cancer and toxic nodular goiter (4 patients) or Basedow disease (2 patients) or scintigraphic evidence of single hyperfunctioning nodule (3 patients). Six out of the 9 cases were diagnosed as papillary cancer, while three as follicular cancer. A carcinoma was diagnosed before operation in only one case, while in the other 8 patients, the diagnosis was obtained by histological examination of the specimen. Four patients underwent subtotal thyroidectomy, while five patients underwent radical lobectomy. All patients are alive and in good health; the average follow-up was 48 months.
- Published
- 1996
35. [Cystic adenoid carcinoma of the esophagus. Description of a case and review of the literature].
- Author
-
Tonini G, Ragni F, Pezzola D, Balzano R, Villanacci V, and Baronchelli C
- Subjects
- Humans, Male, Middle Aged, Carcinoma, Adenoid Cystic pathology, Carcinoma, Adenoid Cystic therapy, Esophageal Neoplasms pathology, Esophageal Neoplasms therapy
- Abstract
The clinical and histopathologic characteristics of a case of adenoid cystic carcinoma of the esophagus are reported. The authors reviewed the literature on the matter and stressed the more aggressive behaviour of the tumor that differs from the same tumor of the salivary glands and other anatomical sites. Surgical resection is the treatment of choice, however the aggressiveness of the tumor requires, also, a chemo and radiotherapeutic approach.
- Published
- 1995
36. Simultaneous catheter replacement-removal during infectious complications in peritoneal dialysis.
- Author
-
Cancarini GC, Manili L, Brunori G, Camerini C, Zubani R, Colombrita D, Pezzola D, and Maiorca R
- Subjects
- Humans, Infections etiology, Peritonitis etiology, Peritonitis therapy, Reoperation, Catheters, Indwelling adverse effects, Infections therapy, Peritoneal Dialysis adverse effects
- Abstract
The aim of this study was to verify whether the replacement of the peritoneal catheter in a single operation and during infectious complications of peritoneal dialysis is effective and safe. Sixty-eight infectious complications refractory to appropriate antibiotic therapy were treated by this technique: 26 tunnel infections, 22 peritonitis-complicating tunnel infections, 12 refractory peritonitis, and 8 recurrent peritonitis. Operations were successful in all cases of tunnel infection and recurring peritonitis, and in all cases but one of peritonitis-complicating tunnel infection. Ten failures occurred among the 12 catheters removed for refractory peritonitis. Microorganisms cultured in these 10 failures were: Fungi (3 cases), Mycobacterium (2 cases), Pseudomonas (2 cases), Acinetobacter (1 case), Acinetobacter+Pseudomonas (1 case), and Enterococcus (1 case). Complications were 3 one-way obstructions and 2 external dialysate leaks. This study supports the simultaneous catheter replacement-removal procedure during infectious complications of peritoneal dialysis (PD) with the exception of refractory peritonitis; this technique spares the patient the temporary vascular access, the shift to hemodialysis, and a second operation to insert a new catheter. There are few complications.
- Published
- 1994
37. [The diagnosis by a Doppler color echocardiographic method of an aortocaval fistula following the rupture of an aortic aneurysm into the inferior vena cava].
- Author
-
Bolognesi R, Tsialtas D, Straneo U, Pezzola D, and Manca C
- Subjects
- Aortic Aneurysm complications, Aortic Diseases etiology, Arteriovenous Fistula etiology, Humans, Male, Middle Aged, Rupture, Spontaneous, Aortic Aneurysm diagnostic imaging, Aortic Diseases diagnostic imaging, Arteriovenous Fistula diagnostic imaging, Echocardiography, Doppler methods, Vena Cava, Inferior diagnostic imaging
- Abstract
We describe a clinical case presenting 2 rare features. The first was a spontaneous aortocaval fistula which had developed from rupture of an atherosclerotic aortic aneurysm into the inferior vena cava. The second infrequent feature depended on the unusual method by which the diagnosis was performed. In fact, using an echo-color Doppler flow imaging (HP 77020A ultrasound system) with a 2.5 MHz echocardiographic probe abdominal examination showed an aneurysm of the descending aorta that communicated to a dilated inferior vena cava. Furthermore, flow study with color Doppler showed a continuous turbulent, mixed (arterial and venous) blood flow into the inferior vena cava.
- Published
- 1991
38. [Concentration of trace elements in maternal milk, powdered and cow's milk. Considerations on current metabolic and physiologic knowledge].
- Author
-
Caramia G, Muzzarelli RA, Eugeni CE, Pezzola D, and Tanfani F
- Subjects
- Animals, Cattle, Humans, Trace Elements metabolism, Infant Food analysis, Milk analysis, Milk, Human analysis, Trace Elements analysis
- Published
- 1984
39. [The role of electroatmospheric factors in asthmatic pathology in children].
- Author
-
Caramia G, Murri A, Scuterini C, Rinaldini MT, Braccili T, Catalani MP, Pezzola D, Picciotti G, and Tirone M
- Subjects
- Air Ionization, Child, Epidemiologic Methods, Humans, Italy, Asthma etiology, Atmosphere, Electricity adverse effects
- Published
- 1984
40. Cisplatin, high dose folinic acid and 5-fluorouracil in squamous cell carcinoma of the esophagus. A pilot study.
- Author
-
Zaniboni A, Simoncini E, Tonini G, Pezzola D, Farfaglia R, Lancini GP, Marpicati P, Montini E, and Marini G
- Subjects
- Aged, Antineoplastic Combined Chemotherapy Protocols adverse effects, Cisplatin administration & dosage, Female, Fluorouracil administration & dosage, Humans, Leucovorin administration & dosage, Male, Middle Aged, Remission Induction, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Squamous Cell drug therapy, Esophageal Neoplasms drug therapy
- Abstract
We treated 20 patients with squamous cell carcinoma of the esophagus with the following regimen: cisplatin = 100 mg/m2 i.v. day 1, HDFA = 200 mg/m2 i.v. day 1 to 5, 5-fluorouracil = 370 mg/m2 i.v. day 1 to 5 repeated every 28 days. Among the 17 evaluable patients, 4 (23%) had a partial remission, 6 had stable disease while 7 progressed. The median survival for all patients was 6+ months. Grade III or IV toxicity included 2 patients with grade III leukopenia, 1 with grade III thrombocytopenia, 1 patient with grade IV and 3 patients with grade III oral mucositis, 3 patients with grade III diarrhea. The regimen did not seem particularly active in the treatment of squamous cell carcinoma of the esophagus and had manageable but substantial toxicity.
- Published
- 1987
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.