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4,877 results on '"Pezzini A."'

1. The generalized Mukai conjecture for spherical varieties with a reductive general isotropy group

Author

Bravi, Paolo and Pezzini, Guido

Subjects
Mathematics - Algebraic Geometry, Mathematics - Representation Theory, 14M27 (Primary) 14J45 (Secondary)
Abstract

In the case of spherical varieties with reductive general isotropy group we prove a conjecture of G. Gagliardi and J. Hofscheier, which implies the generalized Mukai conjecture of L. Bonavero, C. Casagrande, O. Debarre and S. Druel for these varieties.

Published
2025

2. Built-in Bernal gap in large-angle-twisted monolayer-bilayer graphene

Author

Boschi, Alex, Gebeyehu, Zewdu M., Slizovskiy, Sergey, Mišeikis, Vaidotas, Forti, Stiven, Rossi, Antonio, Watanabe, Kenji, Taniguchi, Takashi, Beltram, Fabio, Fal'ko, Vladimir I., Coletti, Camilla, and Pezzini, Sergio

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Atomically thin materials offer multiple opportunities for layer-by-layer control of their electronic properties. While monolayer graphene (MLG) is a zero-gap system, Bernal-stacked bilayer graphene (BLG) acquires a finite band gap when the symmetry between the layers' potential energy is broken, usually, via a displacement electric field applied in double-gate devices. Here, we introduce a twistronic stack comprising both MLG and BLG, synthesized via chemical vapor deposition, showing a Bernal gap in the absence of external fields. Although a large ($\sim30^{\circ}$) twist angle decouples the MLG and BLG electronic bands near Fermi level, proximity-induced energy shifts in the outermost layers result in a built-in asymmetry, which requires a displacement field of $0.14$ V/nm to be compensated. The latter corresponds to a $\sim10$ meV intrinsic BLG gap, a value confirmed by our thermal-activation measurements. The present results highlight the role of structural asymmetry and encapsulating environment, expanding the engineering toolbox for monolithically-grown graphene multilayers., Comment: 25 pages, 4 figures and supplementary information

Published
2024
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3. Fully Kinetic Simulations of Proton-Beam-Driven Instabilities from Parker Solar Probe Observations

Author

Pezzini, Luca, Zhukov, Andrei N., Bacchini, Fabio, Arrò, Giuseppe, López, Rodrigo A., Micera, Alfredo, Innocenti, Maria Elena, and Lapenta, Giovanni

Subjects
Astrophysics - Solar and Stellar Astrophysics, Physics - Plasma Physics, Physics - Space Physics
Abstract

The expanding solar wind plasma ubiquitously exhibits anisotropic non-thermal particle velocity distributions. Typically, proton Velocity Distribution Functions (VDFs) show the presence of a core and a field-aligned beam. Novel observations made by Parker Solar Probe (PSP) in the innermost heliosphere have revealed new complex features in the proton VDFs, namely anisotropic beams that sometimes experience perpendicular diffusion. In this study, we use a 2.5D fully kinetic simulation to investigate the stability of proton VDFs with anisotropic beams observed by PSP. Our setup consists of a core and an anisotropic beam populations that drift with respect to each other. This configuration triggers a proton-beam instability from which nearly parallel fast magnetosonic modes develop. Our results demonstrate that before this instability reaches saturation, the waves resonantly interact with the beam protons, causing perpendicular heating at the expense of the parallel temperature.

Published
2024
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4. Current trends in antiplatelet strategies for emergent carotid stenting in acute tandem occlusions: a web-based, nationwide survey in the Italian neurovascular community

Author

Milazzo, Nicola, Da Ros, Valerio, Diomedi, Marina, Menozzi, Roberto, Pezzini, Alessandro, Ruggiero, Maria, Simonetti, Luigi, Zini, Andrea, Romano, Daniele Giuseppe, Napoletano, Rosa, Vallone, Stefano, Bigliardi, Guido, Plebani, Mauro, Cappellari, Manuel, Cristaudo, Concetto, Mangiafico, Salvatore, Toni, Danilo, and Consoli, Arturo

Published
2025
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5. Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC.

Author

Lupo, Francesca, Pezzini, Francesco, Pasini, Davide, Fiorini, Elena, Adamo, Annalisa, Veghini, Lisa, Bevere, Michele, Frusteri, Cristina, Delfino, Pietro, Dagosto, Sabrina, Andreani, Silvia, Piro, Geny, Malinova, Antonia, Wang, Tian, De Sanctis, Francesco, Lawlor, Rita, Hwang, Changil, Carbone, Carmine, Amelio, Ivano, Bailey, Peter, Bronte, Vincenzo, Tuveson, David, Scarpa, Aldo, Ugel, Stefano, and Corbo, Vincenzo

Subjects
PANCREATIC CANCER, Animals, Humans, Mice, Axon Guidance, Carcinoma, Pancreatic Ductal, Cell Line, Tumor, Cell Movement, Neuropilin-1, Pancreatic Neoplasms, Phenotype, Semaphorin-3A, Signal Transduction
Abstract

OBJECTIVE: The dysregulation of the axon guidance pathway is common in pancreatic ductal adenocarcinoma (PDAC), yet our understanding of its biological relevance is limited. Here, we investigated the functional role of the axon guidance cue SEMA3A in supporting PDAC progression. DESIGN: We integrated bulk and single-cell transcriptomic datasets of human PDAC with in situ hybridisation analyses of patients tissues to evaluate SEMA3A expression in molecular subtypes of PDAC. Gain and loss of function experiments in PDAC cell lines and organoids were performed to dissect how SEMA3A contributes to define a biologically aggressive phenotype. RESULTS: In PDAC tissues, SEMA3A is expressed by stromal elements and selectively enriched in basal-like/squamous epithelial cells. Accordingly, expression of SEMA3A in PDAC cells is induced by both cell-intrinsic and cell-extrinsic determinants of the basal-like phenotype. In vitro, SEMA3A promotes cell migration as well as anoikis resistance. At the molecular level, these phenotypes are associated with increased focal adhesion kinase signalling through canonical SEMA3A-NRP1 axis. SEMA3A provides mouse PDAC cells with greater metastatic competence and favours intratumoural infiltration of tumour-associated macrophages and reduced density of T cells. Mechanistically, SEMA3A functions as chemoattractant for macrophages and skews their polarisation towards an M2-like phenotype. In SEMA3Ahigh tumours, depletion of macrophages results in greater intratumour infiltration by CD8+T cells and better control of the disease from antitumour treatment. CONCLUSIONS: Here, we show that SEMA3A is a stress-sensitive locus that promotes the malignant phenotype of basal-like PDAC through both cell-intrinsic and cell-extrinsic mechanisms.

Published
2024

6. Reperfusion therapies in patients with acute ischaemic stroke and atrial fibrillation: data on safety and effectiveness from a multi-centre cohort study

Author

Cancelloni, Virginia, Buratti, Mariachiara, Tsivgoulis, Georgios, Furie, Karen L., Tadi, Prasanna, Caso, Valeria, Becattini, Cecilia, Agnelli, Giancarlo, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Alberti, Andrea, Venti, Michele, de Magistris, Ilaria Leone, Acciarresi, Monica, D’Amore, Cataldo, Mosconi, Maria G., Cimini, Ludovica A., Cappellari, Manuel, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Turgut, Bandini, Fabio, Marcheselli, Simona, Pezzini, Alessandro, Sohn, Sung-I. I., Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Ntaios, George, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Sagris, Dimitrios, Adamou, Anastasia, Vadikolias, Kostantinos, Palaiodimou, Lina, Chondrogianni, Maria, Mumoli, Nicola, Galati, Franco, Sacco, Simona, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Silvestrelli, Giorgio, Ciccone, Alfonso, Mancuso, Michelangelo, Orlandi, Giovanni, Pascarella, Rosario, Tassinari, Tiziana, Rueckert, Christina, Baldi, Antonio, Toni, Danilo, Lettieri, Federica, Giuntini, Martina, Lotti, Enrico M., Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Halvatsiotis, Panagiotis, Monaco, Serena, Baronello, Mario M., Csiba, Laszlò, Szabò, Lilla, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel, Patrik, Vanacker, Peter, Barlinn, Kristian, Pallesen, Lars P., Kepplinger, Jessica, Deleu, Dirk, Gourbali, Vanessa, Yaghi, Shadi, and Paciaroni, Maurizio

Published
2024
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7. Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice

Author

Zumerle, Sara, Sarill, Miles, Saponaro, Miriam, Colucci, Manuel, Contu, Liliana, Lazzarini, Edoardo, Sartori, Roberta, Pezzini, Camilla, Rinaldi, Anna, Scanu, Anna, Sgrignani, Jacopo, Locatelli, Patrizia, Sabbadin, Marianna, Valdata, Aurora, Brina, Daniela, Giacomini, Isabella, Rizzo, Beatrice, Pierantoni, Alessandra, Sharifi, Saman, Bressan, Silvia, Altomare, Claudia, Goshovska, Yulia, Giraudo, Chiara, Luisetto, Roberto, Iaccarino, Luca, Torcasio, Cristina, Mosole, Simone, Pasquini, Emiliano, Rinaldi, Andrea, Pellegrini, Laura, Peron, Gregorio, Fassan, Matteo, Masiero, Stefano, Giori, Andrea Maria, Dall’Acqua, Stefano, Auwerx, Johan, Cippà, Pietro, Cavalli, Andrea, Bolis, Marco, Sandri, Marco, Barile, Lucio, Montopoli, Monica, and Alimonti, Andrea

Published
2024
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8. Association between procedural time and outcome in unsuccessful mechanical thrombectomy for acute ischemic stroke: analysis from the Italian Registry of Endovascular Treatment in Acute Stroke

Author

Sallustio, Fabrizio, Nicolini, Ettore, Saia, Valentina, Pracucci, Giovanni, Mascolo, Alfredo Paolo, Marrama, Federico, Gandini, Roberto, Da Ros, Valerio, Diomedi, Marina, Alemseged, Fana, Casetta, Ilaria, Fainardi, Enrico, Castellan, Lucio, Del Sette, Massimo, Limbucci, Nicola, Nencini, Patrizia, Bergui, Mauro, Cerrato, Paolo, Saletti, Andrea, De Vito, Alessandro, Cioni, Samuele, Tassi, Rossana, Simonetti, Luigi, Zini, Andrea, Ruggiero, Maria, Longoni, Marco, Tessitore, Agostino, Ferraù, Ludovica, Cavasin, Nicola, Critelli, Adriana, Vallone, Stefano, Bigliardi, Guido, Zimatore, Domenico Sergio, Petruzzellis, Marco, Boghi, Andrea, Naldi, Andrea, Comai, Alessio, Dall’Ora, Elisa, Sanfilippo, Giuseppina, Persico, Alessandra, Gallesio, Ivan, Sepe, Federica, Menozzi, Roberto, Pezzini, Alessandro, Besana, Michele, Giossi, Alessia, Sanna, Antioco, Tassinari, Tiziana, Burdi, Nicola, Boero, Giovanni, Augelli, Raffaele, Cappellari, Manuel, Cosottini, Mirco, Giannini, Nicola, Romano, Daniele G., Frauenfelder, Giulia, Nuzzi, Paolo Nunzio, Spinelli, Maria Carmela, Paladini, Adriana, Rizzo, Annalisa, Filizzolo, Marco, Mannino, Marina, Timpani, Carmine, De Santis, Federica, Carità, Giuseppe, Russo, Monia, Galvano, Gianluca, Sicurella, Luigi, Mangiafico, Salvatore, and Toni, Danilo

Published
2024
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9. Open-label evaluation of oral trehalose in patients with neuronal ceroid lipofuscinoses

Author

Della Vecchia, Stefania, Gammaldi, Nicola, Ricca, Ivana, Mero, Serena, Doccini, Stefano, Ardissone, Anna, Bagnoli, Silvia, Battini, Roberta, Colombi, Elisa, Favaro, Jacopo, Furlan, Roberto, Giordano, Lucio, Ingannato, Assunta, Mandelli, Alessandra, Manzoni, Francesca Maria Paola, Milito, Giuseppe, Moroni, Isabella, Nacmias, Benedetta, Nardocci, Nardo, Parmeggiani, Lucio, Pezzini, Francesco, Pietrafusa, Nicola, Sartori, Stefano, Specchio, Nicola, Trivisano, Marina, ETS, A.-N. C. L., Simonati, Alessandro, and Santorelli, Filippo Maria

Published
2025
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12. Exactly energy-conserving electromagnetic Particle-in-Cell method in curvilinear coordinates

Author

Croonen, Joost, Pezzini, Luca, Bacchini, Fabio, and Lapenta, Giovanni

Subjects
Physics - Plasma Physics, Physics - Computational Physics
Abstract

In this paper, we introduce and discuss an exactly energy-conserving Particle-in-Cell method for arbitrary curvilinear coordinates. The flexibility provided by curvilinear coordinates enables the study of plasmas in complex-shaped domains by aligning the grid to the given geometry, or by focusing grid resolution on regions of interest without overresolving the surrounding, potentially uninteresting domain. We have achieved this through the introduction of the metric tensor, the Jacobian matrix, and contravariant operators combined with an energy-conserving fully implicit solver. We demonstrate the method's capabilities using a Python implementation to study several one- and two-dimensional test cases: the electrostatic two-stream instability, the electromagnetic Weibel instability, and the geomagnetic environment modeling (GEM) reconnection challenge. The test results confirm the capability of our new method to reproduce theoretical expectations (e.g. instability growth rates) and the corresponding results obtained with a Cartesian uniform grid when using curvilinear grids. Simultaneously, we show that the method conserves energy to machine precision in all cases., Comment: 14 pages, 5 figures

Published
2023

13. Growth and applications of two-dimensional single crystals

Author

Zhang, Zhibin, Forti, Stiven, Meng, Wanqing, Pezzini, Sergio, Hu, Zehua, Coletti, Camilla, Wang, Xinran, and Liu, Kaihui

Subjects
Condensed Matter - Materials Science, Physics - Applied Physics
Abstract

Two-dimensional (2D) materials have received extensive research attentions over the past two decades due to their intriguing physical properties (such as the ultrahigh mobility and strong light-matter interaction at atomic thickness) and a broad range of potential applications (especially in the fields of electronics and optoelectronics). The growth of single-crystal 2D materials is the prerequisite to realize 2D-based high-performance applications. In this review, we aim to provide an in-depth analysis of the state-of-the-art technology for the growth and applications of 2D materials, with particular emphasis on single crystals. We first summarize the major growth strategies for monolayer 2D single crystals. Following that, we discuss the growth of multilayer single crystals, including the control of thickness, stacking sequence, and heterostructure composition. Then we highlight the exploration of 2D single crystals in electronic and optoelectronic devices. Finally, a perspective is given to outline the research opportunities and the remaining challenges in this field.

Published
2023
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14. Scalable High-Mobility Graphene/hBN Heterostructures

Author

Martini, Leonardo, Mišeikis, Vaidotas, Esteban, David, Azpeitia, Jon, Pezzini, Sergio, Paletti, Paolo, Ochapski, Michał, Convertino, Domenica, Hernandez, Mar, Jimenez, Ignacio, and Coletti, Camilla

Subjects
Physics - Applied Physics, Condensed Matter - Materials Science
Abstract

Graphene-hexagonal boron nitride (hBN) scalable heterostructures are pivotal for the development of graphene-based high-tech applications. In this work, we demonstrate the realization of high-quality graphene-hBN heterostructures entirely obtained with scalable approaches. hBN continuous films were grown via ion beam-assisted physical vapor deposition directly on commercially available $SiO_2/Si$ and used as receiving substrates for graphene single-crystal matrixes grown by chemical vapor deposition on copper. The structural, chemical, and electronic properties of the heterostructure were investigated by atomic force microscopy, Raman spectroscopy, and electrical transport measurements. We demonstrate graphene carrier mobilities exceeding $10,000 cm^2/Vs$ in ambient conditions, 30% higher than those directly measured on $SiO_{2}/Si$. We prove the scalability of our approach by measuring more than 100 transfer length method devices over a centimeter scale, which present an average carrier mobility of $7500 \pm 850 cm^{2}/Vs$. The reported high-quality all-scalable heterostructures are of relevance for the development of graphene-based high-performing electronic and optoelectronic applications.

Published
2023
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16. Association of Hypertension With Early‐Onset Cryptogenic Ischemic Stroke by the Presence of Patent Foramen Ovale: A Case–Control Study

Author

Jukka Putaala, Bettina von Sarnowski, Ulf Schminke, Raila Busch, Nicolas Martinez‐Majander, Pauli Ylikotila, Riikka Lautamäki, Marialuisa Zedde, Teresa Grimaldi, Tomi Sarkanen, Marko Virtanen, Kristina Ryliskiene, Diana Zakarkaite, Lauri Tulkki, Jani Pirinen, Radim Licenik, Phillip Ferdinand, Cheryl Oxley, Janika Kõrv, Piibe Muda, Alessandro Pezzini, Carlo Mario Lombardi, Georgios Tsivgoulis, Satu Suihko, Heli Tolppanen, Ana Catarina Fonseca, Patricia Martínez‐Sánchez, Laura Amaya Pascasio, Nilufer Yesilot, Ali Elitok, Ulrike Waje‐Andreassen, Sahrai Saeed, Petra Redfors, Odd Bech‐Hanssen, Juha Huhtakangas, Marja Hedman, Pekka Jäkälä, Juha Sinisalo, and Eva Gerdts

Subjects
blood pressure, foramen ovale, patent, hypertension, ischemic stroke, risk factors, Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2024
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17. Phonon-mediated room-temperature quantum Hall transport in graphene

Author

Vaquero, Daniel, Clericò, Vito, Schmitz, Michael, Delgado-Notario, Juan Antonio, Martín-Ramos, Adrian, Salvador-Sánchez, Juan, Müller, Claudius S. A., Rubi, Km, Watanabe, Kenji, Taniguchi, Takashi, Beschoten, Bernd, Stampfer, Christoph, Diez, Enrique, Katsnelson, Mikhail I., Zeitler, Uli, Wiedmann, Steffen, and Pezzini, Sergio

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

The quantum Hall (QH) effect in two-dimensional electron systems (2DESs) is conventionally observed at liquid-helium temperatures, where lattice vibrations are strongly suppressed and bulk carrier scattering is dominated by disorder. However, due to large Landau level (LL) separation (~2000 K at B = 30 T), graphene can support the QH effect up to room temperature (RT), concomitant with a non-negligible population of acoustic phonons with a wave-vector commensurate to the inverse electronic magnetic length. Here, we demonstrate that graphene encapsulated in hexagonal boron nitride (hBN) realizes a novel transport regime, where dissipation in the QH phase is governed predominantly by electron-phonon scattering. Investigating thermally-activated transport at filling factor 2 up to RT in an ensemble of back-gated devices, we show that the high B-field behaviour correlates with their zero B-field transport mobility. By this means, we extend the well-accepted notion of phonon-limited resistivity in ultra-clean graphene to a hitherto unexplored high-field realm., Comment: 17 pages, 4 figures. Supplementary information available at https://doi.org/10.1038/s41467-023-35986-3

Published
2023
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18. Predictors and Prognostic Impact of Hematoma Expansion in Infratentorial Cerebral Hemorrhage

Author

Pezzini, Debora, Nawabi, Jawed, Schlunk, Frieder, Li, Qi, Mazzacane, Federico, Busto, Giorgio, Scola, Elisa, Arba, Francesco, Brancaleoni, Laura, Giacomozzi, Sebastiano, Simonetti, Luigi, Laudisi, Michele, Cavallini, Anna, Katsanos, Aristeidis H., Shoamanesh, Ashkan, Zini, Andrea, Casetta, Ilaria, Fainardi, Enrico, Morotti, Andrea, and Padovani, Alessandro

Published
2024
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22. Evidence of survival bias in the association between APOE-Є4 and age at ischemic stroke onset

Author

Joanna von Berg, Patrick F. McArdle, Paavo Häppölä, Jeffrey Haessler, Charles Kooperberg, Robin Lemmens, Alessandro Pezzini, Vincent Thijs, Sara L. Pulit, Steven J. Kittner, Braxton D. Mitchell, Jeroen de Ridder, and Sander W. van der Laan

Subjects
genome-wide association study, stroke, age at onset, APOE, atherosclerosis, Genetics, QH426-470
Abstract

IntroductionLarge genome-wide association studies (GWASs) using case–control study designs have now identified tens of loci associated with ischemic stroke (IS). As a complement to these studies, we performed GWAS in a case-only design to identify loci influencing the age at onset (AAO) of ischemic stroke.MethodsAnalyses were conducted in a discovery cohort of 10,857 ischemic stroke cases using a linear regression framework. We meta-analyzed all SNPs with p-value C allele was associated with a 1.29-year earlier stroke AAO (meta p-value = 2.48 x 10−11). This APOE variant has previously been associated with increased mortality and ischemic stroke AAO. We hypothesized that the association with AAO may reflect a survival bias attributable to an age-related decrease in mortality among APOE-Є4 carriers and have no association to stroke AAO per se. A simulation study showed that a variant associated with overall mortality might indeed be detected with an AAO analysis. A variant with a 2-fold increase in mortality risk would lead to an observed effect of AAO that is comparable to what we found.DiscussionIn conclusion, we detected a robust association of the APOE locus with stroke AAO and provided simulations to suggest that this association may be unrelated to ischemic stroke per se but related to a general survival bias.

Published
2024
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23. The balance between hemorrhage and thrombosis in patients surviving spontaneous intracerebral bleeding: the nightmare of a neurologist

Author

Alessandro Pezzini

Subjects
Intracerebral hemorrhage, thrombosis, antithrombotic, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

With approximately 3 million people worldwide affected each year and the highly associated mortality and morbidity, intracerebral hemorrhage is the stroke subtype with the most severe clinical consequences. This is mainly due, on the one hand, to the lack of specific acute treatments, as opposed to the ischemic counterpart of stroke, on the other hand, to the occurrence of further vascular events after the index bleeding [...].

Published
2024
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24. Combining Intravenous Thrombolysis and Dual Antiplatelet Treatment in Patients With Minor Ischemic Stroke: A Propensity Matched Analysis of the READAPT Study Cohort

Author

Raffaele Ornello, Matteo Foschi, Federico De Santis, Michele Romoli, Tiziana Tassinari, Valentina Saia, Silvia Cenciarelli, Chiara Bedetti, Chiara Padiglioni, Bruno Censori, Valentina Puglisi, Luisa Vinciguerra, Maria Guarino, Valentina Barone, Marialuisa Zedde, Ilaria Grisendi, Marina Diomedi, Maria Rosaria Bagnato, Marco Petruzzellis, Domenico Maria Mezzapesa, Pietro Di Viesti, Vincenzo Inchingolo, Manuel Cappellari, Cecilia Zivelonghi, Paolo Candelaresi, Vincenzo Andreone, Giuseppe Rinaldi, Alessandra Bavaro, Anna Cavallini, Stefan Moraru, Pietro Querzani, Valeria Terruso, Marina Mannino, Alessandro Pezzini, Giovanni Frisullo, Francesco Muscia, Maurizio Paciaroni, Maria Giulia Mosconi, Andrea Zini, Ruggiero Leone, Carmela Palmieri, Letizia Maria Cupini, Michela Marcon, Rossana Tassi, Enzo Sanzaro, Cristina Paci, Giovanna Viticchi, Daniele Orsucci, Anne Falcou, Simone Beretta, Roberto Tarletti, Patrizia Nencini, Eugenia Rota, Federica Nicoletta Sepe, Delfina Ferrandi, Luigi Caputi, Gino Volpi, Salvatore La Spada, Mario Beccia, Claudia Rinaldi, Vincenzo Mastrangelo, Francesco Di Blasio, Paolo Invernizzi, Giuseppe Pelliccioni, Maria Vittoria De Angelis, Laura Bonanni, Giampietro Ruzza, Emanuele Alessandro Caggia, Monia Russo, Agnese Tonon, Maria Cristina Acciarri, Sabrina Anticoli, Cinzia Roberti, Giovanni Manobianca, Gaspare Scaglione, Francesca Pistoia, Alberto Fortini, Antonella De Boni, Alessandra Sanna, Alberto Chiti, Leonardo Barbarini, Marcella Caggiula, Maela Masato, Massimo Del Sette, Francesco Passarelli, Maria Roberta Bongioanni, Danilo Toni, Stefano Ricci, Eleonora De Matteis, and Simona Sacco

Subjects
dual antiplatelet treatment, functional outcome, intravenous thrombolysis, ischemic stroke, real world, safety, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background The optimal treatment for acute minor ischemic stroke is still undefined. and options include dual antiplatelet treatment (DAPT), intravenous thrombolysis (IVT), or their combination. We aimed to investigate benefits and risks of combining IVT and DAPT versus DAPT alone in patients with MIS. Methods and Results This is a prespecified propensity score‐matched analysis from a prospective multicentric real‐world study (READAPT [Real‐Life Study on Short‐Term Dual Antiplatelet Treatment in Patients With Ischemic Stroke or Transient Ischemic Attack]). We included patients with MIS (National Institutes of Health Stroke Scale score at admission ≤5), without prestroke disability (modified Rankin scale [mRS] score ≤2). The primary outcomes were 90‐day mRS score of 0 to 2 and ordinal mRS distribution. The secondary outcomes included 90‐day risk of stroke and other vascular events and 24‐hour early neurological improvement or deterioration (≥2‐point National Institutes of Health Stroke Scale score decrease or increase from the baseline, respectively). From 1373 patients with MIS, 240 patients treated with IVT plus DAPT were matched with 427 patients treated with DAPT alone. At 90 days, IVT plus DAPT versus DAPT alone showed similar frequency of mRS 0 to 2 (risk difference, 2.3% [95% CI −2.0% to 6.7%]; P=0.295; risk ratio, 1.03 [95% CI 0.98–1.08]; P=0.312) but more favorable ordinal mRS scores distribution (odds ratio, 0.57 [95% CI 0.41–0.79]; P

Published
2024
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27. Defining short-term outcomes of minor ischemic stroke due to small artery occlusion in the era of dual antiplatelet treatment: A READAPT study sub-analysis

Author

Foschi, Matteo, De Matteis, Eleonora, De Santis, Federico, Romoli, Michele, Tassinari, Tiziana, Saia, Valentina, Cenciarelli, Silvia, Bedetti, Chiara, Padiglioni, Chiara, Censori, Bruno, Puglisi, Valentina, Vinciguerra, Luisa, Guarino, Maria, Barone, Valentina, Zedde, Marialuisa, Grisendi, Ilaria, Diomedi, Marina, Bagnato, Maria Rosaria, Petruzzellis, Marco, Mezzapesa, Domenico Maria, Di Viesti, Pietro, Inchingolo, Vincenzo, Cappellari, Manuel, Zivelonghi, Cecilia, Candelaresi, Paolo, Andreone, Vincenzo, Rinaldi, Giuseppe, Bavaro, Alessandra, Cavallini, Anna, Moraru, Stefan, Querzani, Pietro, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Frisullo, Giovanni, Muscia, Francesco, Paciaroni, Maurizio, Mosconi, Maria Giulia, Zini, Andrea, Leone, Ruggiero, Palmieri, Carmela, Cupini, Letizia Maria, Marcon, Michela, Tassi, Rossana, Sanzaro, Enzo, Paci, Cristina, Viticchi, Giovanna, Orsucci, Daniele, Falcou, Anne, Diamanti, Susanna, Tarletti, Roberto, Nencini, Patrizia, Rota, Eugenia, Sepe, Federica Nicoletta, Ferrandi, Delfina, Caputi, Luigi, Volpi, Gino, La Spada, Salvatore, Beccia, Mario, Rinaldi, Claudia, Mastrangelo, Vincenzo, Di Blasio, Francesco, Invernizzi, Paolo, Pelliccioni, Giuseppe, De Angelis, Maria Vittoria, Bonanni, Laura, Ruzza, Giampietro, Caggia, Emanuele Alessandro, Russo, Monia, Tonon, Agnese, Acciarri, Maria Cristina, Anticoli, Sabrina, Roberti, Cinzia, Manobianca, Giovanni, Scaglione, Gaspare, Pistoia, Francesca, Fortini, Alberto, De Boni, Antonella, Sanna, Alessandra, Chiti, Alberto, Barbarini, Leonardo, Caggiula, Marcella, Masato, Maela, Del Sette, Massimo, Passarelli, Francesco, Bongioanni, Maria Roberta, Toni, Danilo, Ricci, Stefano, Sacco, Simona, and Ornello, Raffaele

Published
2024
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28. Disentangling the veil line for Brazilian biodiversity: An overview from two long-term research programs reveals huge gaps in ecological data reporting

Author

Guimaraes, Aretha Franklin, de Alagao Querido, Luciano Carramaschi, Rocha, Taina, de Jesus Rodrigues, Domingos, Viana, Pedro Lage, de Godoy Bergallo, Helena, Fernandes, Geraldo Wilson, Toma, Tiago Shizen Pacheco, Streit, Helena, Overbeck, Gerhard Ernst, de Souza, Alberico Queiroz Salgueiro, Lima, Albertina Pimentel, da Rosa, Clarissa Alves, de Viveiros Grelle, Carlos Eduardo, Lopes, Alessandra Monteiro, Curcino, Alexandre, de Paula, Alexandre Souza, Andriolo, Aline, dos Santos Dias, Aline, Santos, Aline Tavares, Bernardes, Amanda Araujo, da Silva Oliveira, Amanda Batista, de Barros, Ana Angelica Monteiro, e Silva, Ana Carolina Borges Lins, da Cruz, Ana Carolina Rodrigues, de Holanda, Ana Sofia Sousa, Bueno, Anderson Saldanha, Nunes-Freitas, Andre Felippe, Yves, Andre, da Silva Alencar, Andreia, Scabin, Andressa Barbara, Manzatto, Angelo Gilberto, Lima, Antonio Cesar Silva, Pontes, Antonio Rossano Mendes, Castro, Arlison B., Gomes, Arthur Monteiro, Banhos, Aureo, Rosado, Bruno H.P., dos Santos Batista, Caio Augusto, Siqueira, Carla Costa, Fontana, Carla Suertegaray, da Rocha, Carlos Frederico Duarte, Brocardo, Carlos R., da Costa Doria, Carolina Rodrigues, Castilho, Carolina Volkmer, Pessanha, Caroline, Cordeiro, Cesar A.M.M., Cronemberger, Cecilia, Andretti, Christian Borges, Cornelius, Cintia, Campos, Ciro, Borges-Matos, Clarice, Barros, Claudia Franca, Keller, Claudia, de Oliveira Cavalcante, Claymir, de Sales Dambros, Cristian, da Silva Machado, Davi Nepomuceno, Tassinari, Diego, Villela, Dora Maria, Chiaraniv, Eduardo, de Farias Geisler, Eduardo, Velez-Martin, Eduardo, Carvalho-Junior, Elildo Alves Ribeiro, Drechsler-Santos, Elisandro Ricardo, Lourenco, Elizabete Captivo, Franklin, Elizabeth, Higashikawa, Emilio Manabu, Pezzini, Flavia, de Oliveira Roque, Fabio, Baccaro, Fabricio Beggiato, Becker, Fernando Gertum, Cabeceira, Fernando Goncalvez, do Prado Florencio, Fernando, Barbosa, Flavia Rodrigues, Zuquim, Gabriela, Ferreira, Guilherme Braga, de Vargas, Guilherme Krahl, Mourao, Guilherme, Rousseau, Guillaume Xavier, de Lima, Haroldo Cavalcante, Farias, Hugo Leonardo Sousa, Kaefer, Igor Luis, Ghizoni, Ivo Rohling, da Costa de Noronha, Janaina, de Oliveira, Jaqueline Lopes, Santos, Jhonson Reginaldo Silva, Jarenkow, Joao Andre, de Melo-Junior, Joao Carlos Ferreira, dos Santos, Joao Vitor Chave, de Oliveira, Jocieli, de Souza, Jorge Luiz Pereira, Baumgratz, Jose Fernando Andrade, de Morais, Jose Wellinton, de Melo Silva, Joyce, de Gois Silva, Julia, Wingert, Juliana M., Menger, Juliana, Ferrer, Juliano, Dayrell, Jussara Santos, da Silva-Goncalves, Kelly Cristina, Torralvo, Kelly, da Silva Cruz, Kely, da Silva Sylvestre, Lana, de Andrade Ribas, Leonor, Battirola, Leandro Dênis, Ramos, Leticia, Caires, Leticia Rocha, da Silva Carvalho, Lidiany Camila, Stegmann, Lis Fernandes, Carvalho, Lucelia Nobre, da Silva Menezes, Luciana, Costa, Luciana Moraes, Podgaiski, Luciana Regina, Silveira, Luis Fabio, Malabarba, Luiz Roberto, Frangipani, Marcelo Araujo, Tabarelli, Marcelo, Nascimento, Marcelo Trindade, Marques, Marcia Cristina Mendes, Spies, Marcia R., de Oliveira dos Santos, Marco Antonio, Anaicy, Marcos, Vital, Marcos Jose Salgado, Silveira, Marcos, Vieira, Marcus Vinicius, de Moura Araujo, Maria Aparecida, de Almeida Silveira, Maria Aurea Pinheiro, Barros, Maria Fabiola, Faitanin, Mariana Alves, Iguatemy, Mariana, da Cunha, Mariana Souza, da Silva Murakami, Mariana Moreira, Messias, Mariluce Rezende, Martins, Marlucia Bonifacio, Camana, Mateus, de Medeiros Correa, Nadjara, Fonseca, Nathan Castro, Prieto-Benavides, Oscar Oswaldo, Pena Rodrigues, Pablo J.F., de Andrade, Paloma Leal, Pequeno, Pedro Aurelio Costa Lima, Gananca, Pedro Henrique Salomao, da Silva Ferreira, Pedro Paulo, de Andrade, Poliana Cristina Rodrigues, Azarak, Priscila Alencar, de Fraga, Rafael, Rabelo, Rafael M., de Lima Santos, Raylanne, Barbosa, Reinaldo Imbrozio, Dala-Corte, Renato Bolson, Vicente, Ricardo Eduardo, de Oliveira Perdiz, Ricardo, da Cunha Araujo, Rodrigo Paulo, de Andrade, Ricardo Teixeira Gregorio, de Cassia Quitete Portela, Rita, Fadini, Rodrigo, Feitosa, Rodrigo Machado, Santa-Brigida, Rosangela, Cerqueira, Rui, Muller, Sandra Cristina, Santorelli, Sergio, dos Santos, Sonia Barbosa, Cechin, Sonia Zanini, Avilla, Stefano Spiteri, Pansini, Susamar, Aragon, Susan, da Silva Figueiredo, Taina, Sobroza, Tainara Venturini, de Fatima Ramos Guimaraes, Tais, dos Santos, Talitha Ferreira, Emilio, Thaise, de Azevedo Amorim, Thiago, Izzo, Thiago, Sogral, Thadeu, dos Santos, Tiago Gomes, Vincent, Timothy Lee, de Lima Rocha, Tomas, Pillar, Valerio D., Mesquita, Vanessa Pontes, Silva, Vinicius Duncan, Cyrino, Vitor Melo Erse, Borges-Junior, Vitor Nelson Teixeira, Layme, Viviane Maria Guedes, Mota, Wendarlem Galvao, Santos, Wenderson Nunes, Drose, William, Silva, Williamar Rodrigues, and Magnusson, William E.

Published
2024
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30. Moir\'e-Induced Transport in CVD-Based Small-Angle Twisted Bilayer Graphene

Author

Piccinini, Giulia, Mišeikis, Vaidotas, Novelli, Pietro, Watanabe, Kenji, Taniguchi, Takashi, Polini, Marco, Coletti, Camilla, and Pezzini, Sergio

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

To realize the applicative potential of 2D twistronic devices, scalable synthesis and assembly techniques need to meet stringent requirements in terms of interface cleanness and twist-angle homogeneity. Here, we show that small-angle twisted bilayer graphene assembled from separated CVD-grown graphene single-crystals can ensure high-quality transport properties, determined by a device-scale-uniform moire\'e potential. Via low-temperature dual-gated magnetotransport, we demonstrate the hallmarks of a $2.4^\circ$ -twisted superlattice, including tunable regimes of interlayer coupling, reduced Fermi velocity, large interlayer capacitance, and density-independent Brown-Zak oscillations. The observation of these moir\'e-induced electrical transport features establishes CVD-based twisted bilayer graphene as an alternative to 'tear-and-stack' exfoliated flakes for fundamental studies, while serving as a proof-of-concept for future large-scale assembly., Comment: This is the unedited authors' version of the submitted article, published in its final form on Nano Letters 2022 at https://pubs.acs.org/doi/full/10.1021/acs.nanolett.2c01114 , main text, 17 pages, 4 figures

Published
2022
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31. Light emission properties of mechanical exfoliation induced extended defects in hexagonal boron nitride flakes

Author

Ciampalini, G., Tappy, C. V. Blaga. N., Pezzini, S., Watanabe, Taniguchi, Bianco, F, Roddaro, S., Morral, A. Fontcuberta i, and Fabbri, F.

Subjects
Condensed Matter - Materials Science, Physics - Applied Physics
Abstract

Recently hBN has become an interesting platform for quantum optics due to the peculiar defect-related luminescence properties. Concomitantly, hBN was established as the ideal insulating support for realizing 2D materials device, where, on the contrary, defects can affect the device performance. In this work, we study the light emission properties of hBN flakes obtained by mechanical exfoliation with particular focus on extended defects generated in the process. In particular, we tackle different issues as the light emission in hBN flakes of different thicknesses in the range of hundreds of nm, revealing a higher concentration of deep level emission in thinner area of the flake. We recognize the effect of crystal deformation in some areas of the flake with an important blue-shift (130 meV) of the room temperature near band edge emission of hBN and the concurrent presence of a novel emission at 2.36 eV related to the formation of array of dislocations. We studied the light emission properties by means of cathodoluminescence and sub-bandgap excitation photoluminescence of thickness steps with different crystallographic orientations, revealing the presence of different concentration of radiative centers. CL mapping allows to detect buried thickness steps, invisible to the SEM and AFM morphological analysis., Comment: 27 pages, 6 figures, 1 table

Published
2022
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34. Susceptibility to brain ischemia and the association between migraine and spontaneous cervical artery dissection

Author

Del Zotto, Elisabetta, Grassi, Mario, Zedde, Marialuisa, Zini, Andrea, Bersano, Anna, Gandolfo, Carlo, Silvestrelli, Giorgio, Baracchini, Claudio, Cerrato, Paolo, Lodigiani, Corrado, Marcheselli, Simona, Paciaroni, Maurizio, Spalloni, Alessandra, Cappellari, Manuel, Del Sette, Massimo, Cavallini, Anna, Lotti, Enrico Maria, DeLodovici, Maria Luisa, Gentile, Mauro, Magoni, Mauro, Padroni, Marina, Azzini, Cristiano, Calloni, Maria Vittoria, Giorli, Elisa, Braga, Massimiliano, La Spina, Paolo, Melis, Fabio, Tassi, Rossana, Terruso, Valeria, Calabrò, Rocco Salvatore, Piras, Valeria, Giossi, Alessia, Sanguigni, Sandro, Zanferrari, Carla, Mannino, Marina, Colombo, Irene, Dallocchio, Carlo, Nencini, Patrizia, Bignamini, Valeria, Adami, Alessandro, Bella, Rita, Pascarella, Rosario, and Pezzini, Alessandro

Published
2023
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37. Corrigendum: Tandem occlusions involving the internal carotid and anterior cerebral arteries—A rare form of stroke: results from the multicenter EVATRISP collaboration study

Author

Andrei Filioglo, Naaem Simaan, Asaf Honig, Mirjam Heldner, Alessandro Pezzini, Nicolas Martinez-Majander, Visnja Padjen, Philipp Baumgartner, Panagiotis Papanagiotou, Alexander Salerno, Christian Nolte, Annika Nordanstig, Stefan Engelter, Andrea Zini, Marialuisa Zedde, João Pedro Marto, Marcel Arnold, Mauro Magoni, Henrik Gensicke, Jose Cohen, and Ronen Leker

Subjects
cerebrovascular disease, endovascular, stroke, thrombectomy, anterior cerebral artery, Neurology. Diseases of the nervous system, RC346-429
Published
2024
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38. La isla como laboratorio semiótico de la identidad. Robinson revisitado

Author

Isabella Pezzini

Subjects
Mitismo de la isla, Inversión, Subversión, Identidad, Alteridad, Social Sciences
Abstract

En esta intervención, retomaré la insistencia y la convergencia de intereses de una serie de estudiosos significativos para mí en torno a algunos textos fundamentales de la literatura isleña. Son testimonio, como clásicos del canon occidental y fuente renovable de interpretaciones siempre nuevas, de lo que podríamos llamar precisamente la eficacia de la literatura -o del texto estético en general- para articular los temas fundamentales de la condición humana. Esta eficacia podría consistir, en última instancia, en la capacidad de tratar de forma figurada, es decir, no sobre la base de argumentos puramente racionales y/o cognitivos, sino a través de narraciones e incluso figuraciones fantásticas, cuestiones complejas y fundamentales. Concretamente, veremos los resultados de la inversión del mito de Robinson por Michel Tournier en los comentarios de Algirdas Julien Greimas y Bruno Latour.

Published
2024

40. Parallel transport and layer-resolved thermodynamic measurements in twisted bilayer graphene

Author

Piccinini, Giulia, Mišeikis, Vaidotas, Watanabe, Kenji, Taniguchi, Takashi, Coletti, Camilla, and Pezzini, Sergio

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We employ dual-gated 30{\deg}-twisted bilayer graphene to demonstrate simultaneous ultra-high mobility and conductivity (up to 40 mS at room temperature), unattainable in a single-layer of graphene. We find quantitative agreement with a simple phenomenology of parallel conduction between two pristine graphene sheets, with a gate-controlled carrier distribution. Based on the parallel transport mechanism, we then introduce a method for in situ measurements of the chemical potential of the two layers. This twist-enabled approach, neither requiring a dielectric spacer, nor separate contacting, has the potential to greatly simplify the measurement of thermodynamic quantities in graphene-based systems of high current interest., Comment: This is the unedited authors' version of the submitted article, published in Phys. Rev. B 104, L241410 (2021), 23 pages, main text and supplementary information

Published
2021
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42. Lack of hemodynamic changes in critically ill Covid-19 patients using enteral nutrition with arginine: A prospective observational study

Author

Ricardo Schilling Rosenfeld, Mariana Rubin Pezzini, Cledia Deberaldini, Gian Pietro Filippo, Mariana Albuquerque, and Juan B. Ochoa Gaultier

Subjects
SARS-CoV-2, COVID-19, Arginine, Enteral nutrition, Hemodynamics, Nutrition. Foods and food supply, TX341-641
Abstract

Summary: Background & Aims: This study aims to correlate recommended arginine doses for an immunomodulatory effect to hemodynamic changes during the first week of enteral nutrition (EN) in SARS-CoV-2 patients. Methods: This is a prospective observational study of critically ill SARS-CoV2 patients. Patients were followed during the early ICU acute phase. EN was administered according to gastrointestinal tolerance to feeding. Arginine doses were correlated with hemodynamic, perfusion, and IV drug changes. Results: From December 2020 to May 2021, we prospectively and sequentially included 64 SARS-CoV-2 patients. Supplemental arginine delivered above the recommendations for normal individuals (≥6 g/d) did not result in significant hemodynamic changes measured by mean arterial pressure (MAP), systolic arterial pressure (SAP), need for higher vasopressors doses, or tissue hypoperfusion clinical signs (P = 0.063). Arginine doses >10g/day were reached on the fifth ICU admission day. Addition of arginine did not increase vasopressor requirements (mean dose

Published
2023
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43. Manifestações de um trauma existir e resistir à violência contra as mulheres em Mulheres empilhadas, de Patrícia Melo

Author

Paula Grinko Pezzini

Subjects
female authorship, brazilian literature, latin america, Romanic languages, PC1-5498, French literature - Italian literature - Spanish literature - Portuguese literature, PQ1-3999
Abstract

In Latin America, literary works produced by authoresses seek to contest discourses sacralized by the colonial/modern gender system. In Mulheres empilhadas(2019), writer Patrícia Melo highlights multiple forms of violence against women to perceive Brazilian social constructs through lenses that focus on a different perspective from the one built for centuries regarding female bodies. In this paper, I intend to analyze narrative strategies used by the authoress so that themes such as pain and manifestations derived from traumatic processes are addressed. Based on studies by Rita Segato (2003), who contextualizes the structural elements of Latin American violence; María Lugones (2008), who emphasizes the decolonial perspective and coloniality of gender; Zilá Bernd (2013), on memory and narratives of resistance; and Lúcia Zolin (2019), who stresses Feminist Literary Criticism as a methodology for analyzing literary texts – in addition to other Latin American feminists who depart from the epistemologies of the South –, I conclude thatMulheres empilhadas challenges patriarchal conceptions by representing the collective struggle of women as a possibility of resistance.

Published
2023
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44. Long-Term Risk of Arterial Thrombosis After Intracerebral Hemorrhage: MUCH-Italy

Author

Pezzini, Alessandro, Iacoviello, Licia, Di Castelnuovo, Augusto, Costanzo, Simona, Tarantino, Barbara, de Gaetano, Giovanni, Zedde, Marialuisa, Marcheselli, Simona, Silvestrelli, Giorgio, Ciccone, Alfonso, DeLodovici, Maria Luisa, Princiotta Cariddi, Lucia, Paciaroni, Maurizio, Azzini, Cristiano, Padroni, Marina, Gamba, Massimo, Magoni, Mauro, Del Sette, Massimo, Tassi, Rossana, De Franco, Ivo Giuseppe, Cavallini, Anna, Calabrò, Rocco Salvatore, Cappellari, Manuel, Giorli, Elisa, Giacalone, Giacomo, Lodigiani, Corrado, Zenorini, Mara, Valletta, Francesco, Pascarella, Rosario, Grisendi, Ilaria, Assenza, Federica, Napoli, Manuela, Moratti, Claudio, Acampa, Maurizio, and Grassi, Mario

Published
2024
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49. Developing the Protocol Infrastructure for DNA Sequencing Natural History Collections

Author

Giada Ferrari, Lore Esselens, Michelle Hart, Steven Janssens, Catherine Kidner, Maurizio Mascarello, Joshua Peñalba, Flávia Pezzini, Thomas von Rintelen, Gontran Sonet, Carl Vangestel, Massimiliano Virgilio, and Peter Hollingsworth

Subjects
Museomics, hDNA, biodiversity genomics, natural hi, Biology (General), QH301-705.5
Abstract

Intentionally preserved biological material in natural history collections represents a vast repository of biodiversity. Advances in laboratory and sequencing technologies have made these specimens increasingly accessible for genomic analyses, offering a window into the genetic past of species and often permitting access to information that can no longer be sampled in the wild. Due to their age, preparation and storage conditions, DNA retrieved from museum and herbarium specimens is often poor in yield, heavily fragmented and biochemically modified. This not only poses methodological challenges in recovering nucleotide sequences, but also makes such investigations susceptible to environmental and laboratory contamination. In this paper, we review the practical challenges associated with making the recovery of DNA sequence data from museum collections more routine. We first review key operational principles and issues to address, to guide the decision-making process and dialogue between researchers and curators about when and how to sample museum specimens for genomic analyses. We then outline the range of steps that can be taken to reduce the likelihood of contamination including laboratory set-ups, workflows and working practices. We finish by presenting a series of case studies, each focusing on protocol practicalities for the application of different mainstream methodologies to museum specimens including: (i) shotgun sequencing of insect mitogenomes, (ii) whole genome sequencing of insects, (iii) genome skimming to recover plant plastid genomes from herbarium specimens, (iv) target capture of multi-locus nuclear sequences from herbarium specimens, (v) RAD-sequencing of bird specimens and (vi) shotgun sequencing of ancient bovid bone samples.

Published
2023
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50. Sub-THz wireless transmission based on graphene-integrated optoelectronic mixer

Author

Alberto Montanaro, Giulia Piccinini, Vaidotas Mišeikis, Vito Sorianello, Marco A. Giambra, Stefano Soresi, Luca Giorgi, Antonio D’Errico, K. Watanabe, T. Taniguchi, Sergio Pezzini, Camilla Coletti, and Marco Romagnoli

Subjects
Science
Abstract

Abstract Optoelectronics is a valuable solution to scale up wireless links frequency to sub-THz in the next generation antenna systems and networks. Here, we propose a low-power consumption, small footprint building block for 6 G and 5 G new radio wireless transmission allowing broadband capacity (e.g., 10–100 Gb/s per link and beyond). We demonstrate a wireless datalink based on graphene, reaching setup limited sub-THz carrier frequency and multi-Gbit/s data rate. Our device consists of a graphene-based integrated optoelectronic mixer capable of mixing an optically generated reference oscillator approaching 100 GHz, with a baseband electrical signal. We report >96 GHz optoelectronic bandwidth and −44 dB upconversion efficiency with a footprint significantly smaller than those of state-of-the-art photonic transmitters (i.e.,

Published
2023
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