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The interview with Dr. med. Nadine Peukert, specialist in dermatology and venereology, discusses the innovative combination product HArmonyCaTM, which is referred to as a biostimulator of the latest generation. The product consists of cross-linked hyaluronic acid and calcium hydroxylapatite and offers different treatment options than traditional fillers through a dual mechanism of action. It can replenish lost volume and improve skin elasticity. The product can be used in various ways to restore lost facial contours and improve skin structure. It is suitable for patients who desire an immediate and long-lasting lifting effect and an improvement in skin structure. The recommendation is to inject the product retrogradely with a blunt cannula. The significant difference between calcium hydroxylapatite products with active ingredient combinations based on methylcellulose and hyaluronic acid lies in their immediate effect and durability. Products with hyaluronic acid have an immediate lifting effect that can last 3-12 months, while products with carboxymethylcellulose are absorbed after 2-3 months. The mode of action of the products cannot be compared, as the carrier gel methylcellulose degrades more quickly, while the hyaluronic acid is broken down over several months and continuously releases additional CaHA microspheres. [Extracted from the article]