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7 results on '"Petukhova LM"'

1. Protein degradation to low-molecular compounds after death and during reanimation

Author

A A Vinarskaya, Petukhova Lm, Anna S. Konikova, Antonina V. Pogossova, and V I Nikulin

Subjects
Resuscitation, Spleen, Hypothermia, Protein degradation, Postmortem Changes, Bone and Bones, Pathology and Forensic Medicine, In vivo, medicine, Protein biosynthesis, Animals, Amino Acids, Hypoxia, chemistry.chemical_classification, Muscles, Brain, Proteins, Hypoxia (medical), Amino acid, Death, medicine.anatomical_structure, chemistry, Biochemistry, Liver, Spinal Cord, Rabbits, medicine.symptom, Peptides
Abstract

The process of protein degradation to amino acids and peptides in rabbits following death and during reanimation in terms of the effects of artificial postmortem cooling on that process has been studied. Protein degradation was judged by increase of low-molecular nitrogenous compounds in serum and in organs by increase in soluble radioactivity with time in animals the proteins of which had been marked in vivo with radioisotopes. It has been found that immediately after death resulting from acute anoxia the processes of protein degradation to amino acids as well as synthesis stops in liver, skeletal and cardiac muscles, spleen, brain and spinal cord. Similar phenomenon takes place in the case of deep hypothermy. During reanimation the process of protein degradation to low-molecular compounds in organs restores.

Published
1975

2. [Tetragastrin activation of rat gastric mucosa adenyl cyclase in vitro].

Author

Karelin AA and Petukhova LM

Subjects
Animals, Drug Synergism, Enzyme Activation, Histamine Antagonists, In Vitro Techniques, Male, Rats, Tetragastrin administration & dosage, Adenylyl Cyclases metabolism, Cimetidine administration & dosage, Gastric Mucosa enzymology, Gastrins pharmacology, Guanidines administration & dosage, Histamine pharmacology, Tetragastrin pharmacology
Abstract

The effect of tetragastrin and histamine on the adenylate cyclase activity of the rat gastric mucosa was examined in vitro. Tetragastrin and histamine were demonstrated to stimulate the activity of the enzyme in question. The antagonist of histamine H2-receptors, cimetidine inhibits the stimulatory effect of histamine in vitro and activates tetragastrin stimulation of the adenylate cyclase activity. It is suggested that tetragastrin and histamine activate adenylate cyclase of the rat gastric mucosa via different receptors.

Published
1981

3. [Importance of cooling after death for restoration of metabolism during resuscitation].

Author

Pogosova AV, Petukhova LM, Nikulin VI, and Konikova AS

Subjects
Acute Disease, Animals, Chinchilla, DNA biosynthesis, Hypothermia, Induced, Hypoxia metabolism, Male, Protein Biosynthesis, RNA biosynthesis, Rabbits, Hypoxia therapy, Resuscitation
Abstract

Incorporation of labelled metabolites into proteins, RNA and DNA was completely inhibited in rabbit tissues under conditions of prolonged hypothermia (10 degrees). The incorporation of labelled metabolites into all the biopolymers studied was restored after subsequent warming up to 38 degrees. Within 60-90 min after death of the animals due to acute anoxia, the labelled metabolites did not incorporate into protein, RNA and DNA. Artificial postmortal hypothermia (20 degrees) increased (by about 2.5-3-fold) the period of viability, during which reanimation is possible. The hypothermia enables subsequent restoration of the anabolic processes from the zero level.

Published
1978

4. Restoration of nucleic acid biosynthesis after clinical death and factors stimulating the process in vivo.

Author

Konikova AS, Petukhova LM, Pogossova AV, Vinarskaya AA, and Nikulin VI

Subjects
Adenosine Triphosphate blood, Animals, Myocardium metabolism, Pancreas metabolism, Rabbits, Spinal Cord metabolism, Stimulation, Chemical, Time Factors, Cold Temperature, DNA biosynthesis, Death, RNA biosynthesis, Resuscitation
Abstract

The biosynthesis of RNA and DNA falls almost to zero in 60 min after the death of rabbits from anoxia, in all the organs of the body. Rapid artificial cooling of the rabbits to 20 degrees C undertaken within 10 min after death preserved nucleic acid biosynthesis and permitted restoration of life 3-4 h after death, with recovery beginning in 60 min. During the reanimation the addition of ATP to the blood stimulated the restoration of RNA biosynthesis in the spinal cord to a considerable extent; the addition of cocarboxylase to the blood promoted cardiac RNA biosynthesis as well as cardiac and pancreatic DNA biosynthesis during recovery.

Published
1975
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5. Protein degradation to low-molecular compounds after death and during reanimation.

Author

Konikova AS, Vinarskaya AA, Nikulin VI, Pogossova AV, and Petukhova LM

Subjects
Amino Acids metabolism, Animals, Bone and Bones metabolism, Brain metabolism, Hypothermia, Hypoxia, Liver metabolism, Muscles metabolism, Peptides metabolism, Postmortem Changes, Rabbits, Spinal Cord metabolism, Spleen metabolism, Death, Proteins metabolism, Resuscitation
Abstract

The process of protein degradation to amino acids and peptides in rabbits following death and during reanimation in terms of the effects of artificial postmortem cooling on that process has been studied. Protein degradation was judged by increase of low-molecular nitrogenous compounds in serum and in organs by increase in soluble radioactivity with time in animals the proteins of which had been marked in vivo with radioisotopes. It has been found that immediately after death resulting from acute anoxia the processes of protein degradation to amino acids as well as synthesis stops in liver, skeletal and cardiac muscles, spleen, brain and spinal cord. Similar phenomenon takes place in the case of deep hypothermy. During reanimation the process of protein degradation to low-molecular compounds in organs restores.

Published
1975
Full Text
View/download PDF

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