37 results on '"Pettus, Liping H."'
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2. Asymmetric syn-selective aldol reactions of gamma-oxygenated vinylogous urethane with a second generation of chiral auxiliary: application in construction of (+)-3-deoxy-D-manno-2-octulosonic acid
3. Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2
4. Discovery of (R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies
5. Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors
6. The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors
7. Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2
8. Discovery of (R)‑8-(6-Methyl-4-oxo-1,4,5,6-tetrahydro-pyrrolo[3,4‑b]-pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)-amino)-quinazolin-4(3H)‑one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological...
9. Phosphoinositide-3-kinase inhibitors: Evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511
10. Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors
11. Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors
12. Synthesis and structure–activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold
13. Identification of triazolopyridazinones as potent p38α inhibitors
14. Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors
15. Part 2: Structure–activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase
16. Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease
17. Part 1: Structure–Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase
18. Correction to Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511
19. Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511
20. Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases
21. ChemInform Abstract: Asymmetric syn-Selective Aldol Reactions of γ-Oxygenated Vinylogous Urethane with a Second Generation Chiral Auxiliary: Application in Construction of (+)-3-Deoxy-D-manno-2-octulosonic Acid.
22. Discovery and Evaluation of 7-Alkyl-1,5-bis-aryl-pyrazolopyridinones as Highly Potent, Selective, and Orally Efficacious Inhibitors of p38α Mitogen-Activated Protein Kinase⊥⊥ Atomic coordinates and structure factors for crystal structure of compound3dwith p38α can be accessed using PDB code 3LHJ.
23. Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility
24. 3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38α Mitogen-Activated Protein Kinase†
25. Cycloadditions of o-Quinone Dimethides with p-Quinol Derivatives: Regiocontrolled Formation of Anthracyclic Ring Systems.
26. Synthesis of (±)-Epoxysorbicillinol Using a Novel Cyclohexa-2,5-dienone with Synthetic Applications to Other Sorbicillin Derivatives
27. Enantioselective Hydride Abstraction in Organic Substrates: A Novel Use for Chiral Carbenium Ions†
28. Asymmetric Syn-Selective Aldol Reactions of γ-Oxygenated Vinylogous Urethane with a Second Generation Chiral Auxiliary: Application in Construction of (+)-3-Deoxy-d-manno-2-octulosonic Acid
29. Cycloadditions of o-quinone dimethides with p-quinol derivatives: regiocontrolled formation of anthracyclic ring systems
30. Selective Class I Phosphoinositide3-KinaseInhibitors: Optimization of a Series of Pyridyltriazines Leading tothe Identification of a Clinical Candidate, AMG 511.
31. Structure-Based Designof a Novel Series of Potent, Selective Inhibitors of the Class IPhosphatidylinositol 3-Kinases.
32. Asymmetric Syn-Selective Aldol Reactions of ...-Oxygenated Vinylogous Urethane with a Second...
33. ChemInform Abstract: Asymmetric syn-Selective Aldol Reactions of γ-Oxygenated Vinylogous Urethane with a Second Generation Chiral Auxiliary: Application in Construction of (+)-3-Deoxy-D-manno-2-octulosonic Acid.
34. AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients With MTAP-Deleted Cancers.
35. Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.
36. Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.
37. Small molecule p38 MAP kinase inhibitors for the treatment of inflammatory diseases: novel structures and developments during 2006-2008.
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