150 results on '"Pettit, Shirley"'
Search Results
2. Risk Factors for Hospital Readmission Following Noncardiac Surgery: International Cohort Study
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McGillion, Michael H., Borges, Flavia K., Conen, David, Sessler, Daniel I., Coleman, Brenda L., Marcucci, Maura, Ouellette, Carley, Bird, Marissa, Whitmore, Carly, Henry, Shaunattonie, Ofori, Sandra, Pettit, Shirley M., Bedini, Deborah M., Gauthier, Leslie P., Lounsbury, Jennifer, Carter, Nancy M., Tandon, Vikas, Patel, Ameen, Cafaro, Teresa, Simunovic, Marko R., Harlock, John A., Heels-Ansdell, Diane, Elias, Fadi, Rapanos, Theodore, Forbes, Shawn, Peter, Elizabeth, Watt-Watson, Judy, Metcalfe, Kelly, Carroll, Sandra L., and Devereaux, Philip J.
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- 2024
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3. Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial
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Conen, David, Devereaux, PJ, Vincent, Jessica, Wang, Michael Ke, Wells, Jennifer R., Healey, Jeff S., Landoni, Giovanni, McIntyre, William F., Popova, Ekaterine, Sessler, Daniel I., Srinathan, Sadeesh K., Amir, Mohammed, Bangdiwala, Shrikant I., Bossard, Matthias, Chan, Matthew TV, Eikelboom, John W., Fleischmann, Edith, Jolly, Sanjit, Montes, Felix Ramón, Reimer, Cara, Schmartz, Denis, Wang, Chew Yin, Ofori, Sandra N., Blum, Steffen, Alvarez-Garcia, Jesus, Lo Bianco, Giuliana, Traquair, Hugh, Guerrero-Pinedo, Fernando Andres, Oleynick, Christopher, Meyre, Pascal B., Méndez-Zurita, Francisco, Chiarella-Redfern, Helene, Marcucci, Maura, Donati, Francesco, Gonzalez-Osuna, Aranzazu, Minervini, Fabrizio, Moreno Weidmann, Zoraida, Guerra-Ramos, Jose M., Dion, Gabriel, Ramos-Pachón, Anna, Borges, Flavia K., de Sa Boasquevisque, Danielle, Mosconi, Maria Giulia, Amarenco, Pierre, Mitchell, L. Brent, Wyse, George, Cheng, Davy, McAlister, Finlay A., Wells, George A., Baskaran, Geethan, Burns, Andrew T., Gennaccaro, Julia, Howe, Rosemary, Mastrangelo, Louise, Pettit, Shirley, Popovic, Michelle, Shahbaz, Subana, Tosh, Makayla, Zucchetto, Simona J., Heenan, Laura, Lee, Shun Fu, Li, Zhuoru, Xu, Lizhen, Kabon, Barbara, Hoetzenecker, Konrad, Schweiger, Thomas, Reiterer, Christian, Zotti, Oliver, Bsuchner, Paul, Hochreiter, Beatrix, Taschner, Alexander, Adamowitsch, Nikolas, Horvath, Katharina, Hantáková, Nicole, Bidgoli, Javad, Huybrechts, Isabelle, Cappeliez, Serge, Neary, John D., Shargall, Yaron, Tandon, Vikas, Finley, Christian, Agzarian, John, Hanna, Waël, Abdulrahman, Muammar, Lawrence, Kelly, Gregus, Krysten, Quraishi, Faraaz, Wikkerink, Spencer, Wallace, Christine, Prine, Merissa, Gregus, Emily, Hare, Jacqueline, Lombardo, Kristen, Fezia, Behashta, Columbus, Teresa, Rushton, Jacob, DuMerton, Deborah, Reid, Ken, Parlow, Joel, Chung, Wiley, Karizhenskaia, Maria, Malik, Aftab, Tanzola, Rob, Giles, Andrew, McLean, Sean R., McGuire, Anna, Lohser, Jens, Lim, Shirley, Grey, Rebecca, Yee, John, Grant, Kyle, Lee, Alex L., Choi, James J., Dewar, Leith R., Durkin, Christopher, Schisler, Travis, Hecht, Patrick, Hughes, Bevan, Kidane, Biniam, Liu, Richard, Tan, Lawrence, Gowing, Stephen, Buduhan, Gordon, Enns, Stephanie, Poole, Emma, Graham, Kristin, Dubik, Niina, Chin, Alex, Maziak, Donna E., Seely, Andrew JE, Gilbert, Sebastien, Villeneuve, P. James, Sundaresan, Sudhir, Gingrich, Molly, Fazekas, Anna, Bucciero, Kirby, Malthaner, Richard A., Lewis, Deb, Fortin, Dalilah, Qiabi, Mehdi, Nayak, Rahul, Plourde, Madelaine Marie, Haider, Tehmina, Murphy, Rowan, Sellers, Daniel, Donahoe, Laura, Lefebvre, Marco, Lanthier, Luc, Ko, Michael Augustine, Parente, David, Cheung, Victoria, Schieman, Colin, Bessissow, Amal, Wong, Randolph HL, Joynt, Gavin M., Lam, Carmen KM, Lau, Rainbow WH, Wan, Innes YP, Underwood, Malcolm J., Wu, William KK, Wong, Wai Tat, Choi, Gordon YS, Lee, Eva, Hui, Ka Yan, Fung, Beaker, Chan, Chee Sam, Ng, Fung Kei, Thung, Kin Hoi, Gutiérrez-Soriano, Laura, Castañeda, Laura Carmenza, Téllez, Luis Jaime, Ortiz-Ramirez, Lina Marcela, Baiardo-Redaelli, Martina, Belletti, Alessandro, Dieci, Elisa, Monaco, Fabrizio, Muriana, Piergiorgio, Nakhnoukh, Cristina, Novellis, Pierluigi, Turi, Stefano, Viscardi, Stefano, Veronesi, Giulia, Voltolini, Luca, Bongiolatti, Stefano, Salvicchi, Alberto, Gatteschi, Lavinia, Indino, Rossella, Tombelli, Simone, Ravasin, Alice, Salimbene, Ottavia, Rosboch, Giulio Luca, Balzani, Eleonora, Ceraolo, Edoardo, Neitzert, Luca, Brazzi, Luca, Londero, Francesco, Grossi, William, Massullo, Domenico, Fiorelli, Silvia, Margaritora, Stefano, Hashim, Shahrul Amry, Krishnasamy, Sivakumar, See, Woan Shiang, Nawaz, Mohammed Asghar, Bilal, Haris, Trujillo Reyes, Juan Carlos, Martínez-Téllez, Elisabeth, Belda Sanchis, Josep, Planas Canovas, Georgina, Libreros Niño, Alejandra, Parera Ruiz, Ana, Cladellas Gutierrez, Esther, Guarino, Mauro, Urrutia Cuchi, Gerard, Argilaga Nogues, Marta, Rovira Juan, Anna, Medina-Aedo, Melixa, Turró Castillejo, Mª Asunción, Gil Sanchez, Josep Mª, Araúz-Sarmiento, Ibell, Herranz Perez, Gracia, Chavarria Murillo, Stephania, Garcia-Osuna, Alvaro, Rodriguez-Arias, Ainhoa, Berga Garrote, Nuria, Martín Grande, Ascension, Parise Roux, Diego, Gajate Martín, Luis, De Pablo Pajares, Angélica, Candela Toha, Angel Manuel, Moreno Mata, Nicolás, Muñoz Molina, Gema, Caballero Silva, Usue, Cabañero, Alberto, Fra Fernandez, Sara, Cavestany García-Matres, Cristina, Simón, Luisa, Montenegro, Cristina, Pozo, Sergio, Gonzàlez-Tallada, Anna, González Suarez, Susana, Ribas Ball, Montserrat, De Nadal Clanchet, Miriam, Pérez Vélez, Javier, Cruz, Patrícia, Sánchez-Pedrosa, Guillermo, Duque, Patricia, González, Guillermo, Huerta, Luis, Rodríguez, Laura, Garutti, Ignacio, Ruiz-Villa, Laura, Martí-Ejarque, Maria del Mar, Gili-Bueno, Mireia, Maddio Vieyra, Ricardo Matias, Fibla, Juan J., Durán, Núria, de Temple Pla, Marina, Rodríguez-Fuster, Alberto, Bermejo-Martínez, Silvia, Carramiñana, Albert, Opitz, Isabelle, Etienne, Harry, Cata, Juan P., Guerra-Londono, Juan Jose, Rajaram, Ravi, Corrales, German, Vaporciyan, Ara, Mehran, Reza, Sepesi, Boris, Walsh, Garrett, Rice, David, Cukierman, Daniel S., Swisher, Stephen, Marchant, Bryan E., Harris, Lynne C., Cusson, Bruce D., Miller, Scott A., Ayad, Sabry, Araujo, Jorge, Marquez-Roa, Leonardo, Hofstra, Richard L., Wudel, Jr., Leonard J., Minear, Steven C., Teixeira, Camila, Pimentel, Mario, Popoff, Andrew M., Marsack, Kelly, Meehan, Sarah, Chen, Tzonghuei H., Essandoh, Michael, Poppers, Jeremy S., Ke Wang, Michael, Chan, Matthew T V, Cata, Juan P, McLean, Sean R, Srinathan, Sadeesh K, Reyes, Juan Carlos Trujillo, Grande, Ascension Martín, Tallada, Anna Gonzalez, Sessler, Daniel I, Maziak, Donna E, McIntyre, William F, Wong, Randolph H L, McGuire, Anna L, Roux, Diego Parise, Wells, Jennifer R, Ofori, Sandra N, Eikelboom, John W, Jolly, Sanjit S, Healey, Jeff S, and Devereaux, P J
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- 2023
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4. Rationale and design of the colchicine for the prevention of perioperative atrial fibrillation in patients undergoing major noncardiac thoracic surgery (COP-AF) trial
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Devereaux, Vincent, Jessica, Wang, Michael Ke, Wells, Jennifer R., Conen, David, Devereaux, PJ, Healey, Jeff S., Landoni, Giovanni, McIntyre, William F., Popova, Ekaterine, Sessler, Daniel I., Srinathan, Sadeesh K., Amir, Mohammed, Bangdiwala, Shrikant I., Bossard, Matthias, Chan, Matthew T.V., Eikelboom, John W., Fleischmann, Edith, Jolly, Sanjit S., Montes, Felix Ramón, Reimer, Cara, Schmartz, Denis, Wang, Chew Yin, Alvarez-Garcia, Jesus, Bianco, Giuliana Lo, Blum, Steffen, Boasquevisque, Danielle de Sa, Borges, Flavia K., Chiarella-Redfern, Helene, Gonzalez-Osuna, Aranzazu, Guerra-Ramos, Jose M., Marcucci, Maura, Meyre, Pascal B., Ofori, Sandra N., Oleynick, Christopher, Ramos-Pachón, Anna, Traquair, Hugh, Mitchell, L. Brent, Wyse, George, Cheng, Davy, McAlister, Finlay A., Wells, George A., Baskaran, Geethan, Gennaccaro, Julia, Howe, Rosemary, Mastrangelo, Louise, Pettit, Shirley, Shahbaz, Subana, Tosh, Makayla, Zucchetto, Simona J., Heenan, Laura, Lee, Shun Fu, Li, Zhuoru, Xu, Lizhen, Kabon, Barbara, Reiterer, Christian, Taschner, Alexander, Horvath, Katharina, Adamowitsch, Nikolas, Zotti, Oliver, Hantáková, Nicole, Hochreiter, Beatrix, Huybrechts, Isabelle, Cappeliez, Serge, Neary, John D., Shargall, Yaron, Tandon, Vikas, Finley, Christian, Agzarian, John, Hanna, Waël, Abdulrahman, Muammar, Lawrence, Kelly, Gregus, Krysten, Quraishi, Faraaz, Wikkerink, Spencer, Wallace, Christine, Prine, Merissa, Gregus, Emily, Hare, Jacqueline, Lombardo, Kristen, Fezia, Behashta, Columbus, Teresa, DuMerton, Deborah, Reid, Ken, Parlow, Joel, Chung, Wiley, Karizhenskaia, Maria, Malik, Aftab, Kidane, Biniam, Liu, Richard, Tan, Lawrence, Gowing, Stephen, Buduhan, Gordon, Enns, Stephanie, Poole, Emma, Graham, Kristin, McLean, Sean R., McGuire, Anna, Lohser, Jens, Lim, Shirley, Grey, Rebecca, Grant, Kyle, Lee, Alex L., Choi, James J., Dewar, Leith R., Yee, John, Maziak, Donna E., Seely, Andrew J.E., Gilbert, Sebastien, Villeneuve, P. James, Sundaresan, Sudhir, Moffatt-Bruce, Susan D., Gingrich, Molly, Fazekas, Anna, Bucciero, Kirby, Malthaner, Richard A., Lewis, Deb, Fortin, Dalilah, Qiabi, Mehdi, Nayak, Rahul, Plourde, Madelaine Marie, Sellers, Daniel, Donahoe, Laura, Lefebvre, Marco, Lanthier, Luc, Schieman, Colin, Bessissow, Amal, Joynt, Gavin M., Wong, Randolph H.L., Lau, Rainbow W.H., Wong, Wai Tat, Choi, Gordon Y.S., Lee, Eva, Hui, Ka Yan, Fung, Beaker, Chan, Chee Sam, Gutiérrez-Soriano, Laura, Castañeda, Laura Carmenza, Téllez, Luis Jaime, Ortiz-Ramirez, Lina Marcela, De Santis, Simona, Favaro, Giovanni, Muriana, Piergiorgio, Nakhnoukh, Cristina, Novellis, Pierluigi, Turi, Stefano, Veronesi, Giulia, Angelini, Matteo, Voltolini, Luca, Bongiolatti, Stefano, Salvicchi, Alberto, Gatteschi, Lavinia, Indino, Rossella, Tombelli, Simone, Ravasin, Alice, Salimbene, Ottavia, Rosboch, Giulio Luca, Balzani, Eleonora, Massullo, Domenico, Fiorelli, Silvia, Londero, Francesco, Grossi, William, Ng, Tyng Yan, See, Woan Shiang, Nawaz, Mohammed Asghar, Reyes, Juan Carlos Trujillo, Tellez, Elisabeth Martinez, Sanchis, Josep Belda, Cánovas, Georgina Planas, Ruiz, Ana Parera, Gutierrez, Esther Cladellas, Guarino, Mauro, Cuchi, Gerard Urrutia, Nogues, Marta Argilaga, Juan, Anna Rovira, Medina-Aedo, Melixa, Grande, Ascensión Martín, Roux, Diego Parise, Martín, Luis Gajate, Pajares, Angélica De Pablo, Toha, Angel Manuel Candela, Mata, Nicolás Moreno, Molina, Gema Muñoz, Silva, Usue Caballero, Cabañero, Alberto, Fernandez, Sara Fra, Tallada, Anna Gonzàlez, Suarez, Susana González, Ball, Montserrat Ribas, Clanchet, Miriam De Nadal, Ruiz-Villa, Laura, Martí-Ejarque, M.M., Gili-Bueno, Mireia, Ferrández, Jorge Hernández, Llobet, Neus Pons, Cruz, Patricia, Sánchez-Pedrosa, Guillermo, Duque, Patricia, Azcárate, Leire, Martín-Albo, Lorena, Rodríguez-Fuster, Alberto, Bermejo-Martínez, Silvia, Carramiñana, Albert, Minervini, Fabrizio, Cata, Juan P., Rajaram, Ravi, Corrales, German, Guerra-Londono, Juan Jose, Mehran, Reza, Sepesi, Boris, Walsh, Garrett, Cukierman, Daniel S., Marchant, Bryan E., Harris, Lynne C., Cusson, Bruce D., Miller, Scott A., Minear, Steven C., Teixeira, Camila, Pimentel, Mario, Popoff, Andrew M., Cheung, Wing Lee, Marsack, Kelly, Ayad, Sabry, Araujo, Jorge, Chen, Tzonghuei H., Essandoh, Michael, Poppers, Jeremy S., Trujillo Reyes, Juan Carlos, Gonzalez Tallada, Anna, and Garg, Amit X.
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- 2023
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5. High-Sensitivity Cardiac Troponin I Thresholds to Identify Myocardial Injury After Noncardiac Surgery: A Cohort Study
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Duceppe, Emmanuelle, Borges, Flavia K., Tiboni, Maria, Pearse, Rupert, Chan, Matthew T.V., Srinathan, Sadeesh, Kavsak, Peter A., Garg, Amit X., Sessler, Daniel I., Sapsford, Robert, Heels-Ansdell, Diane, Pettit, Shirley, Vasquez, Javiera, Mueller, Christian, Walsh, Micheal, Szczeklik, Wojciech, Rodseth, Reitze, Lalu, Manoj, Thabane, Lehana, Guyatt, Gordon, and Devereaux, P.J.
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- 2023
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6. Examination of psychological risk factors for chronic pain following cardiac surgery: protocol for a prospective observational study.
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McGillion, Michael H, Henry, Shaunattonie, Busse, Jason W, Ouellette, Carley, Katz, Joel, Choinière, Manon, Lamy, Andre, Whitlock, Richard, Pettit, Shirley, Hare, Jacqueline, Gregus, Krysten, Brady, Katheryn, Dvirnik, Nazari, Yang, Stephen Su, Parlow, Joel, Dumerton-Shore, Deborah, Gilron, Ian, Buckley, D Norman, Shanthanna, Harsha, Carroll, Sandra L, Coyte, Peter C, Ebrahim, Shanil, Isaranuwatchai, Wanrudee, Guerriere, Denise N, Hoch, Jeffrey, Khan, James, MacDermid, Joy, Martorella, Geraldine, Victor, J Charles, Watt-Watson, Judy, Howard-Quijano, Kimberly, Mahajan, Aman, Chan, Matthew TV, Clarke, Hance, and Devereaux, PJ
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cardiac surgery ,health economics ,pain management ,Clinical Sciences ,Public Health and Health Services ,Other Medical and Health Sciences - Abstract
INTRODUCTION:Approximately 400 000 Americans and 36 000 Canadians undergo cardiac surgery annually, and up to 56% will develop chronic postsurgical pain (CPSP). The primary aim of this study is to explore the association of pain-related beliefs and gender-based pain expectations on the development of CPSP. Secondary goals are to: (A) explore risk factors for poor functional status and patient-level cost of illness from a societal perspective up to 12 months following cardiac surgery; and (B) determine the impact of CPSP on quality-adjusted life years (QALYs) borne by cardiac surgery, in addition to the incremental cost for one additional QALY gained, among those who develop CPSP compared with those who do not. METHODS AND ANALYSES:In this prospective cohort study, 1250 adults undergoing cardiac surgery, including coronary artery bypass grafting and open-heart procedures, will be recruited over a 3-year period. Putative risk factors for CPSP will be captured prior to surgery, at postoperative day 3 (in hospital) and day 30 (at home). Outcome data will be collected via telephone interview at 6-month and 12-month follow-up. We will employ generalised estimating equations to model the primary (CPSP) and secondary outcomes (function and cost) while adjusting for prespecified model covariates. QALYs will be estimated by converting data from the Short Form-12 (version 2) to a utility score. ETHICS AND DISSEMINATION:This protocol has been approved by the responsible bodies at each of the hospital sites, and study enrolment began May 2015. We will disseminate our results through CardiacPain.Net, a web-based knowledge dissemination platform, presentation at international conferences and publications in scientific journals. TRIAL REGISTRATION NUMBER:NCT01842568.
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- 2019
7. Determinants of tobacco smoking abstinence one year after major noncardiac surgery: a secondary analysis of the VISION study
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Ofori, Sandra N., Marcucci, Maura, Mbuagbaw, Lawrence, Conen, David, Borges, Flavia K., Chow, Clara K., Sessler, Daniel I., Chan, Matthew T.V., Hillis, Graham S., Pettit, Shirley, Heels-Ansdell, Diane, and Devereaux, Philip J.
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- 2022
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8. Association of Preoperative Growth Differentiation Factor-15 Concentrations and Postoperative Cardiovascular Events after Major Noncardiac Surgery
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Duceppe, Emmanuelle, Borges, Flavia K., Conen, David, Tiboni, Maria, Chan, Matthew T. V., Patel, Ameen, Sessler, Daniel I., Kavsak, Peter A., Ofori, Sandra, Srinathan, Sadeesh, Pearse, Rupert, Jaffe, Allan S., Heels-Ansdell, Diane, Garg, Amit X., Pettit, Shirley, Sapsford, Robert, and Devereaux, P. J.
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- 2023
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9. The relative merits of using a high-sensitivity cardiac Troponin T assay compared to a non-high-sensitivity Troponin T assay after noncardiac surgery
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Borges, Flavia K., primary, Sessler, Daniel I., additional, Tiboni, Maria, additional, Patel, Ameen, additional, LeManach, Yannick, additional, Heels-Ansdell, Diane, additional, Srinathan, Sadeesh, additional, Wang, Chew Yin, additional, Chow, Clara, additional, Duceppe, Emmanuelle, additional, Kavsak, Peter, additional, Ofori, Sandra N., additional, Pettit, Shirley, additional, Berwanger, Otavio, additional, Kurz, Andrea, additional, Turan, Alparslan, additional, Tonelli, Ana Claudia, additional, and Devereaux, PJ, additional
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- 2024
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10. Technology-Enabled Remote Monitoring and Self-Management — Vision for Patient Empowerment Following Cardiac and Vascular Surgery: User Testing and Randomized Controlled Trial Protocol
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Mcgillion, Michael H, Devereaux, P J, Yost, Jennifer, Turner, Andy, Bender, Duane, Scott, Ted, Carroll, Sandra L, Ritvo, Paul, Peter, Elizabeth, Lamy, Andre, Furze, Gill, Krull, Kirsten, Dunlop, Valerie, Good, Amber, Bedini, Debbie, Naus, Frank, Pettit, Shirley, Henry, Shaunattonie, Probst, Christine, Mills, Joseph, Gossage, Elaine, Travale, Irene, Duquette, Janine, Taberner, Christy, Bhavnani, Sanjeev, Khan, James, Cowan, David, Romeril, Eric, Lee, John, Collela, T, Choiniere, Manon, Busse, Jason W, Katz, Joel, Victor, J. Charles, Hoch, Jeffrey S, Isranauwatchai, W, Kaasalainen, Sharon, Ladak, Salima SJ, O'Keefe-McCarthy, Sheila, Parry, Monica, Sessler, Daniel, Stacey, Michael, Stevens, Bonnie, Stremler, Robyn, Thabane, Lehana, Watt-Watson, Judy, Whitlock, Richard, Macdermid, Joy C, Leegaard, Marit, McKelvie, Robert, Hillmer, Michael, Cooper, L, Arthur, Gavin, Sider, Krista, Oliver, Susan, Boyajian, Karen, Farrow, Mark, Lawton, Chris, Gamble, Darryl, Welch, Jake, S LeFort S, Field M, Clyne, Wendy, Ricuppero, Maria, Poole, Laurie, Russell-Wood, Karsten, Weber, Michael, McNeil, Jolene, Alpert, Robyn, Sharpe, Sarah, Bhella, Sue, Mohajer, David, Ponnambalam, Sem, Lakhani, Naeem, Khan, Rabia, and Liu, Peter
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Technology-Enabled ,Remote ,Monitoring ,Self-Management ,Vision ,Patient ,Empowerment ,Following ,Cardiac ,Vascular ,Surgery ,Testing ,Randomized ,Controlled ,Trial ,Protocol - Published
- 2016
11. Association Between Myocardial Injury and Cardiovascular Outcomes of Orthopaedic Surgery: A Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Substudy
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Thomas, Sabu, Borges, Flavia, Bhandari, Mohit, De Beer, Justin, Urrútia Cuchí, Gerard, Adili, Anthony, Winemaker, Mitchell, Avram, Victoria, Chan, Matthew T.V., Lamas, Claudia, Cruz, Patricia, Aguilera, Xavier, Garutti, Ignacio, Alonso-Coello, Pablo, Villar, Juan Carlos, Jacka, Michael, Wang, C.Y., Berwanger, Otavio, Chow, Clara, Srinathan, Sadeesh, Pettit, Shirley, Heels-Ansdell, Dianne, Rubery, Paul, Devereaux, P.J., Thomas, Sabu, Walsh, Michael, Tiboni, Maria, Guyatt, Gordon, Heels-Ansdell, Diane, Thorlund, Kristian, Thabane, Lehana, Bhandari, Mohit, Bosch, Jackie, Chan, Matthew T.V., Shatin, NT, Alonso-Coello, Pablo, Berwanger, Otavio, Carlos Villar, Juan, Wang, C.Y., Garutti, R. Ignacio, Jacka, Michael J., Sigamani, Alben, Srinathan, Sadeesh, Biccard, Bruce M., Rodseth, Reitze N., Chow, Clara K., Abraham, Valsa, Pettit, Shirley, McQueen, Matthew J., VanHelder, Tomas, Szczeklik, Wojciech, Buse, Giovanna Lurati, Botto, Fernando, Yusuf, Salim, Sessler, Daniel I., Kurz, Andrea, Garg, Amit X., Mrkobrada, Marko, Pearse, Rupert M., Polanczyk, Carisi A., Malaga, German, Nagele, Peter, Le Manach, Yannick, Leuwer, Martin, and Devereaux, P.J.
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- 2020
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12. Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study
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Mrkobrada, Marko, Chan, Matthew T.V., Cowan, David, Campbell, Douglas, Wang, Chew Yin, Torres, David, Malaga, German, Sanders, Robert D., Sharma, Manas, Brown, Carl, Sigamani, Alben, Szczeklik, Wojciech, Sharma, Mukul, Guyatt, Gordon, Smith, Eric E., Agid, Ronit, Dmytriw, Adam A., Spence, Jessica, Adunuri, Nikesh R., Borges, Flavia K., Short, Timothy G., Hill, Michael D., Saad, Feryal, Copland, Ingrid, Pettit, Shirley, Ibrahim, Quazi, Bangdiwala, Shrikant I., Yusuf, Salim, Tsai, Scott, Sahlas, Demetrios J, Mensinkai, Arun, Sposato, Luciano A, Hussain, Sara, Yang, Steven, Siegal, Deborah, Khaw, Alexander, Mandzia, Jennifer, Simpson, Sara, Raval, Manoj, Karimuddin, Ahmer, Phang, PT, Mok, Vincent CT, Wu, William KK, Yu, Simon CH, Gin, Tony, Loh, Pui San, Liew, Mun Thing, Ramli, Norlisah, Siow, Yee Lein, Fuentes, Maite, Ortiz-Soriano, Victor, Waymouth, Ellen, Kumar, Jonathan, Sadana, Divya, Thomas, Lenimol, Kaczmarek, Bogusz, Lindroth, Heidi, Sessler, Daniel, Apolcer, Sarah, Trombetta, Amelia, Handsor, Stephanie, Dasgupta, Monidipa, Murkin, John M, Lee, Shun Fu, and Devereaux, P.J.
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- 2019
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13. Preoperative levels of natriuretic peptides and the incidence of postoperative atrial fibrillation after noncardiac surgery: a prospective cohort study
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Szczeklik, Wojciech, LeManach, Yannick, Fronczek, Jakub, Polok, Kamil, Conen, David, McAlister, Finlay A., Srinathan, Sadeesh, Alonso-Coello, Pablo, Biccard, Bruce, Duceppe, Emmanuelle, Heels-Ansdell, Diane, Gorka, Jacek, Pettit, Shirley, Roshanov, Pavel S., and Devereaux, P.J.
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Atrial fibrillation -- Risk factors ,Postoperative complications -- Risk factors ,Natriuretic peptides -- Health aspects ,Health - Abstract
BACKGROUND: Postoperative atrial fibrillation (POAF) is associated with clinically significant short- and long-term complications after noncardiac surgery. Our aim was to describe the incidence of clinically important POAF after noncardiac surgery and establish the prognostic value of N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in this context. METHODS: The Vascular events In noncardiac Surgery patients cOhort evaluatioN (VISION) Study was a prospective cohort study involving patients aged 45 years and older who had inpatient noncardiac surgery that was performed between August 2007 and November 2013. We determined 30-day incidence of clinically important POAF (i.e., resulting in angina, congestive heart failure, symptomatic hypotension or requiring treatment) using logistic regression models to analyze the association between preoperative NT-proBNP and POAF. RESULTS: In 37664 patients with no history of atrial fibrillation, we found that the incidence of POAF was 1.0% (95% confidence interval [CI] 0.9%-1.1%; 369 events); 3.2% (95% CI 2.3%-4.4%) in patients undergoing major thoracic surgery, 1.3% (95% CI 1.2%-1.5%) in patients undergoing major nonthoracic surgery and 0.2% (95% CI 0.1%0.3%) in patients undergoing low-risk surgery. In a subgroup of 9789 patients with preoperative NT-proBNP measurements, the biomarker improved the prediction of POAF risk over conventional prognostic factors (likelihood ratio test p < 0.001; fraction of new information from NT-proBNP was 16%). Compared with a reference NT-proBNP measurement set at 100 ng/L, adjusted odds ratios for the occurrence of POAF were 1.31 (95% CI 1.15-1.49) at 200 ng/L, 2.07 (95% CI 1.27-3.36) at 1500 ng/L and 2.39 (95% CI 1.26-4.51) at 3000 ng/L. INTERPRETATION: We determined that the incidence of clinically important POAF after noncardiac surgery was 1.0%. We also found that preoperative NT-proBNP levels were associated with POAF independent of established prognostic factors. Trial registration: ClinicalTrials.gov, no. NCT00512109, Postoperative atrial fibrillation (POAF) is the most common arrhythmia that occurs after noncardiac surgery (1) and is associated with prolonged hospital stays and an increased risk of stroke and death, [...]
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- 2020
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14. Persistent Incisional Pain after Noncardiac Surgery: An International Prospective Cohort Study
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Khan, James S., Sessler, Daniel I., Chan, Matthew T. V., Wang, C. Y., Garutti, Ignacio, Szczeklik, Wojciech, Turan, Alparslan, Busse, Jason W., Buckley, D. Norman, Paul, James, McGillion, Michael, Fernández-Riveira, Carmen, Srinathan, Sadeesh K., Shanthanna, Harsha, Gilron, Ian, Jacka, Michael, Jackson, Paul, Hankinson, James, Paniagua, Pilar, Pettit, Shirley, and Devereaux, P. J.
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- 2021
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15. Postoperative Remote Automated Monitoring: Need for and State of the Science
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McGillion, Michael H., Duceppe, Emmanuelle, Allan, Katherine, Marcucci, Maura, Yang, Stephen, Johnson, Ana P., Ross-Howe, Sara, Peter, Elizabeth, Scott, Ted, Ouellette, Carley, Henry, Shaunattonie, Le Manach, Yannick, Paré, Guillaume, Downey, Bernice, Carroll, Sandra L., Mills, Joseph, Turner, Andrew, Clyne, Wendy, Dvirnik, Nazari, Mierdel, Sandra, Poole, Laurie, Nelson, Matthew, Harvey, Valerie, Good, Amber, Pettit, Shirley, Sanchez, Karla, Harsha, Prathiba, Mohajer, David, Ponnambalam, Sem, Bhavnani, Sanjeev, Lamy, Andre, Whitlock, Richard, and Devereaux, P.J.
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- 2018
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16. Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial
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Devereaux, P.J., Duceppe, Emmanuelle, Bangdiwala, Shrikant I., Connolly, Stuart, Eikelboom, John, Guyatt, Gordon, Kearon, Clive, Pettit, Shirley, Pogue, Janice, Rodseth, Reitze, Sessler, Daniel I., Vincent, Jessica, Yusuf, Salim, Di Diodato, Sara, Gasic, Zora, Mastrangelo, Louise J., Molnar, Sarah H., Swanson, Jennifer L., Tosh, Makayla L., Wells, Jennifer R., Botto, Fernando, Diaz, Rafael, Chow, Clara K., Berwanger, Otavio, Gonzales, Beatriz, Tandon, Vikas, Villar, Juan Carlos, Vásquez, Skarlet, Jansky, Petr, Dušek, Radovan, Meyhoff, Christian S., Coriat, Pierre, Hoeft, Andreas, Wittmann, Maria, Yonga, Gerald, Xavier, Denis, Rao, Mangala, Mathur, Nandini, Franzosi, Maria Grazia, Seletti, Elena, Malaga, German, Tumanan-Mendoza, Bernadette A., Tagle, Maria Pamela A., Szczeklik, Wojciech, Biccard, Bruce M., Alonso-Coello, Pablo, Popova, Ekaterine, Shields, Martin, Le Manach, Yannick, Moayyedi, Paul, van Zanten, Sander, Fleischmann, Edith, Garg, Amit, Karaye, Kamilu, McFalls, Edward, Sigamani, Alben, Belley-Côté, Emilie, Biedroń, Grzegorz, Borges, Flavia, Frosi Stella, Steffan, Haarmark Nielsen, Christian, Leong, Darryl P., Spence, Jessica, Tran, Allen, Wawrzycka-Adamczyk, Katarzyna, Yang, Stephen S., Yung, Terence, Wyse, D. George, Cheng, Davy, Johnstone, David E., Wells, George A., Joseph, Philip, Patel, Ameen, Gregus, Krysten, Lawrence, Kelly, Doharris, Lindsay, Conen, David, Cheung, Jason, Douketis, Jim, Wright, Douglas, Wikkerink, Spencer, Dechert, William, Panju, Mohamed, Azzam, Khalid, Rapanos, Theodore, Van Helder, Tomas, Shroff, Anjali, Hare, Jacqueline, Kidane, Biniam, Nguyen, Thang, Leydier, Larissa, Bayaraa, Vanessa, Parlow, Joel, DuMerton, Deborah A., Thakrar, Amar, Shelley, Jessica, Deligne, Benoit, Carling, Roberta Daila, Mrkobrada, Marko, Dresser, George K., Jacka, Michael J., Hornstein, David, Winkelaar, Gerrit B., Haider, Zoeb Hussain, Lanjewar, Pravina Prashant, Varughese, Valsamma, Calton, Rajneesh, Ahuja, Hemani, George, Preetha, Sharma, Ambika, Bhatt, Keyur Sureshchandra, Mangukiya, Dhaval Odhavajibhai, Nandaniya, Karshan Vira, Parekh, Viral Vasantrai, Pillai, Ashok Bhaskaran, Menon, Vidya P., Desai, Sanjay Channappa, Sidhu, Ravinder Singh, Gupta, Sandeep Kumar, George, Robbie K., Gurunath, T.R., Drummond, Leanne W., Torborg, Alexandra M., Küsel, Belinda S., Naidoo, Prebashini, Naidoo, Datshana P., Rajah, Chantal, Farina, Zane, von Rahden, Richard Peter, Gumede, Simphiwe, Chishala, Chishala, Coetzee, Ettienne, Dyer, Robert A., Diedericks, Johan, Bielański, Piotr, Kaczmarek, Bogusz, Studzińska, Dorota, Zaniewski, Maciej, Libura, Marek Józef, Zacharias-Nalichowski, Tomasz Mikołaj, Sega, Aurelia A.S., Salwa, Jakub, Kózka, Mateusz, Górka, Jacek, Wludarczyk, Anna, Nowak-Kózka, Ilona, Grudzień, Paweł Szczepan, Gucwa, Jaroslaw W., Słowiaczek, Michał Piotr, Dobosz, Paweł P.D., Gögenur, Ismail, Eriksen, Jens Ravn, Borup, Tine, Kirkegaard, Tove, Isbye, Dan, Sonne, Asger, Rasmussen, Lars S., Pedersen, Sofie, Troensegaard, Hannibal, Duus, Camilla L., Halle, Benedikte M., Gundel, Ossian N., Bernholm, Katrine F., Martinsen, Kristian Rønsholt, Pedersen, Søren, Itenov, Theis S., Camio, Elena, Vázquez, Carles, Matarin, Silvia, Cano, Esther, Álvarez-García, Jesús, India, Inmaculada, González-Osuna, Aránzazu, Vives, Marc, Rosselló, Elena, Serrano, Ana B., Turiel, Maurizio, Drago, Lorenzo, Colombo, Chiara, Marra, Federica, Mos, Lucio, Arteni, Franco, Lembo, Rosalba, Ortalda, Alessandro, Passarani, Simonetta, Mokini, Zhirajr, Figueiredo, Estevao Lanna, Werner, Gustavo Fonseca, Petriz, Joao Luiz, Maia, Lilia Nigro, Bergo, Ricardo R., Precoma, Dalton Bertolim, Saraiva, José Francisco Kerr, Vilamajo, Oscar Gomez, Allegrini, Eduardo, Benzadón, Mariano, Parody, Maria Leonor, Duronto, Ernesto A., Ingaramo, Adrián C., Parra, Gustavo Adolfo, Novoa, Danny, Miller, Scott A., Thomas, Sabu, Karlapudi, Sudhakar P., Bourji, Mohamad H., Banerjee, Subhash, Gupta, Anita, Opole, Isaac O., Fischer, Michal, Mendoza, Victor Lecaros, Reyes, Eugenio Borja, Pierson, Richard J., Shields, Martin O., Piriou, Vincent, Zacharowski, Kai, Rotta-Rotta, Aida, Paper, Main, Srinathan, Sadeesh K., Erb, Jason, Magloire, Patrick, Neary, John, Rahate, Prashant, Chaudhry, Navneet, Mayosi, Bogani, de Nadal, Miriam, Paniagua Iglesias, Pilar, Sharma, Mike, Rao-Melacini, Purnima, Devereaux, P J, Biccard, Bruce M, Meyhoff, Christian S, Srinathan, Sadeesh K, Rahate, Prashant V, Chaudhry, Navneet K, Mayosi, Bongani, Iglesias, Pilar Paniagua, Eikelboom, John W, Sessler, Daniel I, Sharma, Mukul, Connolly, Stuart J, and Bangdiwala, Shrikant I
- Published
- 2018
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17. Design of a Randomized Placebo-Controlled Trial to Assess Dabigatran and Omeprazole in Patients with Myocardial Injury after Noncardiac Surgery (MANAGE)
- Author
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Duceppe, Emmanuelle, Yusuf, Salim, Tandon, Vikas, Rodseth, Reitze, Biccard, Bruce M., Xavier, Denis, Szczeklik, Wojciech, Meyhoff, Christian S., Franzosi, Maria Grazia, Vincent, Jessica, Srinathan, Sadeesh K., Parlow, Joel, Magloire, Patrick, Neary, John, Rao, Mangala, Chaudhry, Navneet K., Mayosi, Bongani, de Nadal, Miriam, Popova, Ekaterine, Villar, Juan Carlos, Botto, Fernando, Berwanger, Otavio, Guyatt, Gordon, Eikelboom, John W., Sessler, Daniel I., Kearon, Clive, Pettit, Shirley, Connolly, Stuart J., Sharma, Mukul, Bangdiwala, Shrikant I., and Devereaux, P.J.
- Published
- 2018
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18. One-year Results of a Factorial Randomized Trial of Aspirin versus Placebo and Clonidine versus Placebo in Patients Having Noncardiac Surgery
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Sessler, Daniel I., Conen, David, Leslie, Kate, Yusuf, Salim, Popova, Ekaterina, Graham, Michelle, Kurz, Andrea, Villar, Juan Carlos, Mrkobrada, Marko, Sigamani, Alben, Biccard, Bruce M., Meyhoff, Christian S., Parlow, Joel L., Guyatt, Gordon, Xavier, Denis, Chan, Matthew T. V., Kumar, Priya A., Forget, Patrice, Malaga, German, Fleischmann, Edith, Amir, Mohammed, Torres, David, Wang, C. Y., Paniagua, Pilar, Berwanger, Otavio, Srinathan, Sadeesh, Landoni, Giovanni, Manach, Yannick Le, Whitlock, Richard, Lamy, André, Balasubramanian, Kumar, Gilron, Ian, Turan, Alparslan, Pettit, Shirley, and Devereaux, P. J.
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- 2020
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19. Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery :An International Randomized Controlled Trial.
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Marcucci, Maura, Painter, Thomas TW, Conen, David, Lomivorotov, Vladimir, Sessler, Daniel I, Chan, Matthew T V, Borges, Flavia K, Leslie, Kate, Duceppe, Emmanuelle, Martínez-Zapata, María José, Wang, Chew Yin, Xavier, Denis, Ofori, Sandra N, Wang, Michael Ke, Efremov, Sergey, Landoni, Giovanni, Kleinlugtenbelt, Ydo YV, Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X, Short, Timothy TG, Wittmann, Maria, Meyhoff, Christian Sylvest, Amir, Mohammed, Torres, David, Patel, Ameen, Ruetzler, Kurt, Parlow, Joel JL, Tandon, Vikas, Fleischmann, Edith, Polanczyk, Carísi Anne, Lamy, Andre, Jayaram, Raja, Astrakov, Sergey SV, Wu, William Ka Kei, Cheong, Chao Chia, Ayad, Sabry, Kirov, Mikhail M.Y., de Nadal, Miriam, Likhvantsev, Valery VV, Paniagua, Pilar, Aguado, Hector HJ, Maheshwari, Kamal, Whitlock, Richard RP, McGillion, Michael MH, Vincent, Jessica, Copland, Ingrid, Balasubramanian, Kumar, Biccard, Bruce BM, Srinathan, Sadeesh, Ismoilov, Samandar, Pettit, Shirley, Stillo, David, Kurz, Andrea, Belley-Côté, Emilie EP, Spence, Jessica, McIntyre, William WF, Bangdiwala, Shrikant SI, Guyatt, Gordon, Yusuf, Salim, Devereaux, P J, POISE-3 Trial Investigators and Study Groups, Marcucci, Maura, Painter, Thomas TW, Conen, David, Lomivorotov, Vladimir, Sessler, Daniel I, Chan, Matthew T V, Borges, Flavia K, Leslie, Kate, Duceppe, Emmanuelle, Martínez-Zapata, María José, Wang, Chew Yin, Xavier, Denis, Ofori, Sandra N, Wang, Michael Ke, Efremov, Sergey, Landoni, Giovanni, Kleinlugtenbelt, Ydo YV, Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X, Short, Timothy TG, Wittmann, Maria, Meyhoff, Christian Sylvest, Amir, Mohammed, Torres, David, Patel, Ameen, Ruetzler, Kurt, Parlow, Joel JL, Tandon, Vikas, Fleischmann, Edith, Polanczyk, Carísi Anne, Lamy, Andre, Jayaram, Raja, Astrakov, Sergey SV, Wu, William Ka Kei, Cheong, Chao Chia, Ayad, Sabry, Kirov, Mikhail M.Y., de Nadal, Miriam, Likhvantsev, Valery VV, Paniagua, Pilar, Aguado, Hector HJ, Maheshwari, Kamal, Whitlock, Richard RP, McGillion, Michael MH, Vincent, Jessica, Copland, Ingrid, Balasubramanian, Kumar, Biccard, Bruce BM, Srinathan, Sadeesh, Ismoilov, Samandar, Pettit, Shirley, Stillo, David, Kurz, Andrea, Belley-Côté, Emilie EP, Spence, Jessica, McIntyre, William WF, Bangdiwala, Shrikant SI, Guyatt, Gordon, Yusuf, Salim, Devereaux, P J, and POISE-3 Trial Investigators and Study Groups
- Abstract
Among patients having noncardiac surgery, perioperative hemodynamic abnormalities are associated with vascular complications. Uncertainty remains about what intraoperative blood pressure to target and how to manage long-term antihypertensive medications perioperatively., SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2023
20. Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial
- Author
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Whitlock, Richard P, Devereaux, P J, Teoh, Kevin H, Lamy, Andre, Vincent, Jessica, Pogue, Janice, Paparella, Domenico, Sessler, Daniel I, Karthikeyan, Ganesan, Villar, Juan Carlos, Zuo, Yunxia, Avezum, Álvaro, Quantz, Mackenzie, Tagarakis, Georgios I, Shah, Pallav J, Abbasi, Seyed Hesameddin, Zheng, Hong, Pettit, Shirley, Chrolavicius, Susan, and Yusuf, Salim
- Published
- 2015
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21. Accelerated Surgery Versus Standard Care in Hip Fracture (HIP ATTACK-1): A Kidney Substudy of a Randomized Clinical Trial
- Author
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Veevaete, Laurent, le Polain de Waroux, Bernard, Lavand'homme, Patricia, Cornu, Olivier, Tribak, Karim, Yombi, Jean C., Touil, Nassim, Bhutia, Jigme T., Clinckaert, Carol, De Clippeleir, Dirk, Reu, Maike, Patel, Ameen, Tandon, Vikas, Gauthier, Leslie P., Avram, Victoria RA., Winemaker, Mitchell, Tushinski, Daniel M., de Beer, Justin, Worster, Andrew, Simpson, Diane L., Alvarado, Kim A., Gregus, Krysten K., Lawrence, Kelly H., Leong, Darryl P., Joseph, Philip G., Magloire, Patrick, Deheshi, Benjamin, Bisland, Stuart, Wood, Thomas J., Wilson, David AJ., Ofori, Sandra N., Spence, Jessica, Duceppe, Emmanuelle, Tiboni, Maria E., Neary, John D., Adili, Anthony, Cowan, David D., Khanna, Vickas, Zaki, Amna, Farrell, Janet C., MacDonald, Anne Marie, Conen, David, Wong, Steven CW., Karbassi, Arsha, Wright, Douglas S., Shanthanna, Harsha, Ganame, Javier, Cheung, Andrew, Coughlin, Ryan, Khan, Moin, Wikkerink, Spencer, Quraishi, Faraaz A., Lawendy, Abdel-Rahman, Kishta, Waleed, Schemitsch, Emil, Carey, Timothy, Macleod, Mark D., Sanders, David W., Vasarhelyi, Edward, Bartley, Debra, Dresser, George K., Tieszer, Christina, Jenkinson, Richard J., Shadowitz, Steven, Lee, Jacques S., Choi, Stephen, Kreder, Hans J., Nousiainen, Markku, Kunz, Monica R., Tuazon, Ravianne, Shrikumar, Mopina, Ravi, Bheeshma, Wasserstein, David, Stephen, David J.G., Nam, Diane, Henry, Patrick D.G., Wood, Gavin CA., Mann, Stephen M., Jaeger, Melanie T., Sivilotti, Marco LA., Smith, Christopher A., Frank, Christopher C., Grant, Heather, Ploeg, Leone, Yach, Jeff D., Harrison, Mark M., Campbell, Aaron R., Bicknell, Ryan T., Bardana, Davide D., Feibel, Robert J., McIlquham, Katie, Gallant, Catherine, Halman, Samantha, Thiruganasambandamoorth, Venkatesh, Ruggiero, Sara, Hadden, William J., Chen, Brian PJ., Coupal, Stephanie A., McMahon, Stephen J., McLean, Lisa M., Shirali, Hemant R., Haider, Syed Y., Smith, Crystal A., Watts, Evan, Santone, David J., Koo, Kevin, Yee, Allan J., Oyenubi, Ademilola N., Nauth, Aaron, Schemitsch, Emil H., Daniels, Timothy R., Ward, Sarah E., Hall, Jeremy A., Ahn, Henry, Whelan, Daniel B., Atrey, Amit, Khoshbin, Amir, Puskas, David, Droll, Kurt, Cullinan, Claude, Payendeh, Jubin, Lefrancois, Tina, Mozzon, Lise, Marion, Travis, Jacka, Michael J., Greene, James, Menon, Matthew, Stiegelmahr, Robert, Dillane, Derek, Irwin, Marleen, Beaupre, Lauren, Coles, Chad P., Trask, Kelly, MacDonald, Shelley, Trenholm, J.A.I., Oxner, William, Richardson, C.G., Dehghan, Niloofar, Sadoughi, Mehdi, Sharma, Achal, White, Neil J., Olivieri, Loretta, Hunt, Stephen B., Turgeon, Thomas R., Bohm, Eric R., Tran, Sarah, Giilck, Stephen M., Hupel, Tom, Guy, Pierre, O'Brien, Peter J., Duncan, Andrew W., Crawford, Gordon A., Zhou, Junlin, Zhao, Yanrui, Liu, Yang, Shan, Lei, Wu, Anshi, Muñoz, Juan M., Chaudier, Philippe, Douplat, Marion, Fessy, Michel Henri, Piriou, Vincent, Louboutin, Lucie, David, Jean Stephane, Friggeri, Arnaud, Viste, Anthony, Vacheron, Charles Hervé, Li Leung, Frankie Ka, Fang, Christian Xinshuo, Hang Yee, Dennis King, Sancheti, Parag K., Pradhan, Chetan V., Patil, Atul A., Puram, Chetan P., Borate, Madhav P., Kudrimoti, Kiran B., Adhye, Bharati A., Dongre, Himanshu V., John, Bobby, Abraham, Valsamma, Pandey, Ritesh A., Rajkumar, Arti, George, Preetha E., Sigamani, Alben, Stephen, Manesh, Chandran, Nitheesh, Ashraf, Mohammed, Georgekutty, A.M., Sulthan, Ahamad S., Adinarayanan, S., Sharma, Deep, Barnawal, Satish P., Swaminathan, Srinivasan, Bidkar, Prasanna U., Mishra, Sandeep K., Menon, Jagdish, Niranjan, M., Varghese, Z.K., Hiremath, Santosh A., Madhusudhan, N.C., Jawali, Abhijit, Gnanadurai, Kingsly R., George, Carolin E., Maddipati, Tatarao, Mary, K.P., Sharma, Vijay, Farooque, Kamran, Malhotra, Rajesh, Mittal, Samarth, Sawhney, Chavi, Gupta, Babita, Mathur, Purva, Gamangati, Shivanand, Tripathy, Vijaylaxmi, Menon, Prem H., Dhillon, Mandeep S., Chouhan, Devendra K., Patil, Sharanu, Narayan, Ravi, Lal, Purushotham, Bilchod, Prashanth N., Singh, Surya U., Gattu, Uttam V., Dashputra, Ravi P., Rahate, Prashant V., Turiel, Maurizio, Accetta, Riccardo, Perazzo, Paolo, Stella, Daniele, Bonadies, Marika, Colombo, Chiara, De Blasio, Giuseppe, Fozzato, Stefania, Pino, Fabio, Morelli, Ilaria, Ortalda, Alessandro, De Donato, Francesco, Colnaghi, Eleonora, Salini, Vincenzo, Placella, Giacomo, Giardina, Giuseppe, Lombardi, Gaetano, Marcato, Anna, Guzzetti, Luca, Rivetti, Ilaria, Greco, Massimiliano, Khor, H.M., Lai, Hou Yee, Kumar, C.S., Chee, K.H., Loh, P.S., Tan, Kit Mun, Singh, Simmrat, Foo, Li Lian, Prakasam, Komella, Chaw, Sook Hui, Lee, Meng-Li, Ngim, Joanne HL., Boon, Huck Wee, Chin, Im Im, Kleinlugtenbelt, Ydo V., Landman, Ellie BM., Flikweert, Elvira R., Roerdink, Herbert W., Brokelman, Roy BG., Elskamp-Meijerman, Hannie F., Staffhorst, Bas, Cobben, Jan-Hein MG., Umer, Masood, Begum, Dilshad, Anjum, Anila, Hashmi, Pervaiz M., Ahmed, Tashfeen, Rashid, Haroon U., Khattak, Mujahid J., Rashid, Rizwan H., Lakdawala, Riaz H., Noordin, Shahryar, Juman, Naveed M., Khan, Robyna I., Riaz, Muhammad M., Bokhari, Syedah S., Almas, Ayesha, Wahab, Hussain, Ali, Arif, Khan, Hammad N., Khan, Eraj K., Nur, Aamer Nabi, Janjua, Kholood A., Orakzai, Sajjad H., Khan, Abdus S., Mustafa, Khawaja J., Sohail, Mian A., Umar, Muhammad, Khan, Siddra A., Ashraf, Muhammad, Khan, Muhammad K., Shiraz, Muhammad, Furgan, Ahmad, Ślęczka, Paweł, Dąbek, Piotr, Kumoń, Adam, Satora, Wojciech, Ambroży, Wojciech, Święch, Mariusz, Rycombel, Jacek, Grzelak, Adrian, Nowak-Kózka, Ilona, Gucwa, Jaroslaw, Machala, Waldemar, Ramokgopa, Mmampapatla T., Firth, Gregory B., Karera, Mwalimu, Fourtounas, Maria, Singh, Virsen, Biscardi, Anna, Iqbal, Muhammad N., Campbell, Ryan J., Maluleke, Matimba L., Moller, Carien, Nhlapo, Lerato, Maqungo, Sithombo, Flint, Margot, Nejthardt, Marcin B., Chetty, Sean, Venter, Stephen, Guerra-Farfan, Ernesto, Tomas-Hernandez, Jordi, Garcia-Sanchez, Yaiza, Clua, Miriam Garrido, Molero-Garcia, Vicente, Teixidor-Serra, Jordi, Villar-Casares, Maria del Mar, Marsa, Jordi Selga, Porcel-Vazquez, Juan A., Andres- Peiro, Jose-Vicente, Mestre-Torres, Jaume, Guilabert, Patricia, Paños Gozalo, M Luisa, Abarca, Luis, Martin, Nuria, Usua, Gemma, Lalueza-Broto, Pilar, Sanchez-Raya, Judith, Nuñez Camarena, Jorge, Fraguas-Castany, Antoni, Piedra Calle, Carlos, Leiva, Diego Soza, Carrasco, Maria Garcia, Balaguer-Castro, Mariano, Jornet-Gibert, Montsant, Monfort-Mira, Montserrat, Gasset-Teixidor, Alfons, Marcano-Fernández, Francesc Antoni, Simó- Sánchez, Isabel, Mari-Alfonso, Begoña, Yela-Verdú, Christian, Pellejero-García, Raúl, Casas-Codina, Júlia, Iglesias- Sanjuan, Ruben, Balcells-Nolla, Pau, Vila-Sánchez, Oriol, de Bustos, Mercè Bertrana, Castillón, Pablo, Bernaus, Martí, Quintas, Saioa, Gómez, Olga, Salvador, Jordi, Abarca, Javier, Estrada, Cristina, Novellas, Marga, Anglès, Francesc, Dealbert, Alfred, Macho, Oscar, Ivanov, Alexia, Valldosera, Esther, Arroyo, Marta, Pey, Borja, Yuste, Antoni, Mateo, Llorenç, De Caso, Julio, Anaya, Rafael, Higa-Sansone, J.L., Millan, Angelica, Baños, Victoria, Herrera-Mateo, Sergio, Aguado, Hector J., García-Virto, Virginia, Simón-Pérez, Clarisa, Chavez, Sergio, Bragado, María, Plata, María, Guerado, Enrique, Cruz, Encarnacion, Cano, Juan R., Bogallo, Jose M., Sa-ngasoongsong, Paphon, Kulachote, Noratep, Sirisreetreerux, Norachart, Pengrung, Nachapan, Chalacheewa, Theerawat, Arnuntasupakul, Vanlapa, Yingchoncharoen, Teerapat, Naratreekoon, Bundit, Kadry, Miriam A., Thayaparan, Surendini, Babu, Victor, Aframian, Arash, Bentoumi, Souad, Sayan, Amrinder, Abdlaziz, Ihab, Vizcaychipi, Marcela P., Correia, Patricia, Patil, Shashank, Haire, Kevin, Mayor, Amy SE., Dillingham, Sally, Nicholson, Laura, Brooke, Ben T., John, Joby, Nanjayan, Shashi K., Parker, Martyn J., O'Sullivan, Susan, Marmor, Meir T., Matityahu, Amir, McClellan, Robert T., Comstock, Curt, Ding, Anthony, Toogood, Paul, Slobogean, Gerard, O’Toole, Robert, Sciadini, Marcus, Nascone, Jason, O’Hara, Nathan, Ryan, Scott P., Clark, Molly E., Cassidy, Charles, Balonov, Konstantin, Weaver, Tristan, Phieffer, Laura S., Bergese, Sergio D., Marcantonio, Andrew J., Devereaux, P.J., Bhandari, Mohit, Borges, Flavia K., Balasubramanian, Kumar, Bangdiwala, Shrikant I., Harvey, Valerie, McGillion, Michael H., Pettit, Shirley, Vincent, Jessica, Dragic-Taylor, Sanela, Maxwell, Chelsea, Molnar, Sarah, Wells, Jennifer R., Forget, Patrice, Landais, Paul, Landoni, Giovanni, Wang, Chew Yin, Szczeklik, Wojciech, Biccard, Bruce M., Popova, Ekaterine, Moppett, Iain K., Roberts, Robin, Chairperson, McAlister, Finlay, Sackett, David, Wright, James, Cuerden, Meaghan, Sontrop, Jessica M., Guerra-Farfán, Ernesto, Neary, John, Tiboni, Maria, Ramokgopa, Mmampapatla Thomas, Sancheti, Parag, Jenkinson, Richard, Wood, Gavin C.A., McMahon, John Stephen, Tomás-Hernández, Jordi, and Garg, Amit X.
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- 2022
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22. High-sensitivity Troponin I Predicts Major Cardiovascular Events after Non-Cardiac Surgery: A Vascular Events in Non-Cardiac Surgery Patients Cohort Evaluation (VISION) Substudy.
- Author
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Borges, Flavia K., Duceppe, Emmanuelle, Heels-Ansdell, Diane, Patel, Ameen, Sessler, Daniel I., Tandon, Vikas, Chan, Matthew, Pearse, Rupert, Srinathan, Sadeesh, Garg, Amit X., Sapsford, Robert J., Ofori, Sandra N., Marcucci, Maura, Kavsak, Peter A., Pettit, Shirley, Spence, Jessica, Belley-Cote, Emilie, McGillion, Michael, Whitlock, Richard, and Lamy, Andre
- Published
- 2023
- Full Text
- View/download PDF
23. Accelerated Surgery Versus Standard Care in Hip Fracture (HIP ATTACK-1): A Kidney Substudy of a Randomized Clinical Trial.
- Author
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UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - SSS/IREC/NMSK - Neuro-musculo-skeletal Lab, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anesthésiologie, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, UCL - (SLuc) Service de médecine interne générale, Borges, Flavia K, Devereaux, P J, Cuerden, Meaghan, Sontrop, Jessica M, Bhandari, Mohit, Guerra-Farfán, Ernesto, Patel, Ameen, Sigamani, Alben, Umer, Masood, Neary, John, Tiboni, Maria, Tandon, Vikas, Ramokgopa, Mmampapatla Thomas, Sancheti, Parag, Lawendy, Abdel-Rahman, Balaguer-Castro, Mariano, Jenkinson, Richard, Ślęczka, Paweł, Nur, Aamer Nabi, Wood, Gavin C A, Feibel, Robert J, McMahon, John Stephen, Biccard, Bruce M, Ortalda, Alessandro, Szczeklik, Wojciech, Wang, Chew Yin, Tomás-Hernández, Jordi, Vincent, Jessica, Harvey, Valerie, Pettit, Shirley, Balasubramanian, Kumar, Slobogean, Gerard, Garg, Amit X, HIP ATTACK-1 Investigators, Veevaete, Laurent, Le Polain de Waroux, Bernard, Lavand'homme, Patricia, Cornu, Olivier, Tribak, Karim, Yombi, Jean Cyr, Touil, Nassim, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - SSS/IREC/NMSK - Neuro-musculo-skeletal Lab, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anesthésiologie, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, UCL - (SLuc) Service de médecine interne générale, Borges, Flavia K, Devereaux, P J, Cuerden, Meaghan, Sontrop, Jessica M, Bhandari, Mohit, Guerra-Farfán, Ernesto, Patel, Ameen, Sigamani, Alben, Umer, Masood, Neary, John, Tiboni, Maria, Tandon, Vikas, Ramokgopa, Mmampapatla Thomas, Sancheti, Parag, Lawendy, Abdel-Rahman, Balaguer-Castro, Mariano, Jenkinson, Richard, Ślęczka, Paweł, Nur, Aamer Nabi, Wood, Gavin C A, Feibel, Robert J, McMahon, John Stephen, Biccard, Bruce M, Ortalda, Alessandro, Szczeklik, Wojciech, Wang, Chew Yin, Tomás-Hernández, Jordi, Vincent, Jessica, Harvey, Valerie, Pettit, Shirley, Balasubramanian, Kumar, Slobogean, Gerard, Garg, Amit X, HIP ATTACK-1 Investigators, Veevaete, Laurent, Le Polain de Waroux, Bernard, Lavand'homme, Patricia, Cornu, Olivier, Tribak, Karim, Yombi, Jean Cyr, and Touil, Nassim
- Abstract
To the Editor: Acute kidney injury (AKI) is a lesser-known complication of hip fracture that may come about owing to decreased kidney perfusion and heightened inflammation from trauma, pain, bleeding, and fasting. Approximately 15%-20% of patients undergoing surgery for a hip fracture develop AKI, with 0.5%-1.8% receiving dialysis. [...]
- Published
- 2022
24. Intraoperative Inspiratory Oxygen Fraction and Myocardial Injury After Noncardiac Surgery:Results From an International Observational Study in Relation to Recent Controlled Trials
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Pedersen, Sofie S., Holse, Cecilie, Mathar, Clara E., Chan, Matthew T.V., Sessler, Daniel I., Liu, Yingzhi, Zhang, Lin, Kurz, Andrea, Jacka, Mike, Torborg, Alexandra, Biyase, Thuli, Montes, Felix R., Wang, Chew Yin, Pettit, Shirley, Devereaux, P. J., Meyhoff, Christian S., Pedersen, Sofie S., Holse, Cecilie, Mathar, Clara E., Chan, Matthew T.V., Sessler, Daniel I., Liu, Yingzhi, Zhang, Lin, Kurz, Andrea, Jacka, Mike, Torborg, Alexandra, Biyase, Thuli, Montes, Felix R., Wang, Chew Yin, Pettit, Shirley, Devereaux, P. J., and Meyhoff, Christian S.
- Abstract
BACKGROUND: Two trials reported that a high inspiratory oxygen fraction (F io2 ) does not promote myocardial infarction or death. Observational studies can provide larger statistical strength, but associations can be due to unobserved confounding. Therefore, we evaluated the association between intraoperative F io2 and cardiovascular complications in a large international cohort study to see if spurious associations were observed. METHODS: We included patients from the Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) study, who were ≥45 years of age, scheduled for overnight hospital admission, and had intraoperative F io2 recorded. The primary outcome was myocardial injury after noncardiac surgery (MINS), and secondary outcomes included mortality and pneumonia, all within 30 postoperative days. Data were analyzed with logistic regression, adjusted for many baseline cardiovascular risk factors, and illustrated in relation to findings from 2 recent controlled trials. RESULTS: We included 6588 patients with mean age of 62 years of whom 49% had hypertension. The median intraoperative F io2 was 0.46 (5%-95% range, 0.32-0.94). There were 808 patients (12%) with MINS. Each 0.10 increase in median F io2 was associated with a confounder-adjusted increase in odds for MINS: odds ratio (OR), 1.17 (95% confidence interval [CI], 1.12-1.23; P < .0001). MINS occurred in contrast with similar frequencies and no significant difference in controlled trials (2240 patients, 194 events), in which patients were given 80% vs 30% oxygen. Mortality was 2.4% and was not significantly associated with a median F io2 (OR, 1.07; 95% CI, 0.97-1.19 per 0.10 increase; P = .18), and 2.9% of patients had pneumonia (OR, 1.05; 95% CI, 0.95-1.15 per 0.10 increase; P = .34). CONCLUSIONS: We observed an association between intraoperative F io2 and risk of myocardial injury within 30 days after noncardiac surgery, which contrasts with recent controlled clinical trials. F io2 w
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- 2022
25. Intraoperative Inspiratory Oxygen Fraction and Myocardial Injury After Noncardiac Surgery: Results From an International Observational Study in Relation to Recent Controlled Trials
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Pedersen, Sofie S., primary, Holse, Cecilie, additional, Mathar, Clara E., additional, Chan, Matthew T. V., additional, Sessler, Daniel I., additional, Liu, Yingzhi, additional, Zhang, Lin, additional, Kurz, Andrea, additional, Jacka, Mike, additional, Torborg, Alexandra, additional, Biyase, Thuli, additional, Montes, Felix R., additional, Wang, Chew Yin, additional, Pettit, Shirley, additional, Devereaux, P. J., additional, and Meyhoff, Christian S., additional
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- 2022
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26. High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality
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Devereaux, P.J., primary, Lamy, Andre, additional, Chan, Matthew T.V., additional, Allard, René V., additional, Lomivorotov, Vladimir V., additional, Landoni, Giovanni, additional, Zheng, Hong, additional, Paparella, Domenico, additional, McGillion, Michael H., additional, Belley-Côté, Emilie P., additional, Parlow, Joel L., additional, Underwood, Malcolm J., additional, Wang, Chew Yin, additional, Dvirnik, Nazari, additional, Abubakirov, Marat, additional, Fominskiy, Evgeny, additional, Choi, Stephen, additional, Fremes, Stephen, additional, Monaco, Fabrizio, additional, Urrútia, Gerard, additional, Maestre, Marialuz, additional, Hajjar, Ludhmila A., additional, Hillis, Graham S., additional, Mills, Nicholas L., additional, Margari, Vito, additional, Mills, Joseph D., additional, Billing, J. Stephen, additional, Methangkool, Emily, additional, Polanczyk, Carisi A., additional, Sant’Anna, Roberto, additional, Shukevich, Dmitry, additional, Conen, David, additional, Kavsak, Peter A., additional, McQueen, Matthew J., additional, Brady, Katheryn, additional, Spence, Jessica, additional, Le Manach, Yannick, additional, Mian, Rajibul, additional, Lee, Shun Fu, additional, Bangdiwala, Shrikant I., additional, Hussain, Sara, additional, Borges, Flavia K., additional, Pettit, Shirley, additional, Vincent, Jessica, additional, Guyatt, Gordon H., additional, Yusuf, Salim, additional, Alpert, Joseph S., additional, White, Harvey D., additional, and Whitlock, Richard P., additional
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- 2022
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27. Post-discharge after surgery Virtual Care with Remote Automated Monitoring-1 (PVC-RAM-1) technology versus standard care: randomised controlled trial
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McGillion, Michael H, primary, Parlow, Joel, additional, Borges, Flavia K, additional, Marcucci, Maura, additional, Jacka, Michael, additional, Adili, Anthony, additional, Lalu, Manoj M, additional, Ouellette, Carley, additional, Bird, Marissa, additional, Ofori, Sandra, additional, Roshanov, Pavel S, additional, Patel, Ameen, additional, Yang, Homer, additional, O’Leary, Susan, additional, Tandon, Vikas, additional, Hamilton, Gavin M, additional, Mrkobrada, Marko, additional, Conen, David, additional, Harvey, Valerie, additional, Lounsbury, Jennifer, additional, Mian, Rajibul, additional, Bangdiwala, Shrikant I, additional, Arellano, Ramiro, additional, Scott, Ted, additional, Guyatt, Gordon H, additional, Gao, Peggy, additional, Graham, Michelle, additional, Nenshi, Rahima, additional, Forster, Alan J, additional, Nagappa, Mahesh, additional, Levesque, Kelsea, additional, Marosi, Kristen, additional, Chaudhry, Sultan, additional, Haider, Shariq, additional, Deuchar, Lesly, additional, LeBlanc, Brandi, additional, McCartney, Colin J L, additional, Schemitsch, Emil H, additional, Vincent, Jessica, additional, Pettit, Shirley M, additional, DuMerton, Deborah, additional, Paulin, Angela Djuric, additional, Simunovic, Marko, additional, Williams, David C, additional, Halman, Samantha, additional, Harlock, John, additional, Meyer, Ralph M, additional, Taylor, Dylan A, additional, Shanthanna, Harsha, additional, Schlachta, Christopher M, additional, Parry, Neil, additional, Pichora, David R, additional, Yousuf, Haroon, additional, Peter, Elizabeth, additional, Lamy, Andre, additional, Petch, Jeremy, additional, Moloo, Husein, additional, Sehmbi, Herman, additional, Waggott, Melissa, additional, Shelley, Jessica, additional, Belley-Cote, Emilie P, additional, and Devereaux, P J, additional
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- 2021
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28. Clonidine in Patients Undergoing Noncardiac Surgery
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Devereaux, P. J., Sessler, Daniel I., Leslie, Kate, Kurz, Andrea, Mrkobrada, Marko, Alonso-Coello, Pablo, Villar, Juan Carlos, Sigamani, Alben, Biccard, Bruce M., Meyhoff, Christian S., Parlow, Joel L., Guyatt, Gordon, Robinson, Andrea, Garg, Amit X., Rodseth, Reitze N., Botto, Fernando, Buse, Giovanna Lurati, Xavier, Denis, Chan, Matthew T.V., Tiboni, Maria, Cook, Deborah, Kumar, Priya A., Forget, Patrice, Malaga, German, Fleischmann, Edith, Amir, Mohammed, Eikelboom, John, Mizera, Richard, Torres, David, Wang, C. Y., VanHelder, Tomas, Paniagua, Pilar, Berwanger, Otavio, Srinathan, Sadeesh, Graham, Michelle, Pasin, Laura, Le Manach, Yannick, Gao, Peggy, Pogue, Janice, Whitlock, Richard, Lamy, André, Kearon, Clive, Chow, Clara, Pettit, Shirley, Chrolavicius, Susan, and Yusuf, Salim
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- 2014
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29. Aspirin in Patients Undergoing Noncardiac Surgery
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Devereaux, P. J., Mrkobrada, Marko, Sessler, Daniel I., Leslie, Kate, Alonso-Coello, Pablo, Kurz, Andrea, Villar, Juan Carlos, Sigamani, Alben, Biccard, Bruce M., Meyhoff, Christian S., Parlow, Joel L., Guyatt, Gordon, Robinson, Andrea, Garg, Amit X., Rodseth, Reitze N., Botto, Fernando, Buse, Giovanna Lurati, Xavier, Denis, Chan, Matthew T.V., Tiboni, Maria, Cook, Deborah, Kumar, Priya A., Forget, Patrice, Malaga, German, Fleischmann, Edith, Amir, Mohammed, Eikelboom, John, Mizera, Richard, Torres, David, Wang, C. Y., VanHelder, Tomas, Paniagua, Pilar, Berwanger, Otavio, Srinathan, Sadeesh, Graham, Michelle, Pasin, Laura, Le Manach, Yannick, Gao, Peggy, Pogue, Janice, Whitlock, Richard, Lamy, André, Kearon, Clive, Baigent, Colin, Chow, Clara, Pettit, Shirley, Chrolavicius, Susan, and Yusuf, Salim
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- 2014
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30. Post Discharge after Surgery Virtual Care with Remote Automated Monitoring Technology (PVC-RAM): protocol for a randomized controlled trial
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McGillion, Michael H., primary, Parlow, Joel, additional, Borges, Flavia K., additional, Marcucci, Maura, additional, Jacka, Michael, additional, Adili, Anthony, additional, Lalu, Manoj M., additional, Yang, Homer, additional, Patel, Ameen, additional, O’Leary, Susan, additional, Tandon, Vikas, additional, Hamilton, Gavin M., additional, Mrkobrada, Marko, additional, Ouellette, Carley, additional, Bird, Marissa, additional, Ofori, Sandra, additional, Conen, David, additional, Roshanov, Pavel S., additional, Harvey, Valerie, additional, Guyatt, Gordon H., additional, Le Manach, Yannick, additional, Bangdiwala, Shrikant I., additional, Arellano, Ramiro, additional, Scott, Ted, additional, Lounsbury, Jennifer, additional, Taylor, Dylan A., additional, Nenshi, Rahima, additional, Forster, Alan J., additional, Nagappa, Mahesh, additional, Lamy, Andre, additional, Peter, Elizabeth, additional, Levesque, Kelsea, additional, Marosi, Kristen, additional, Chaudhry, Sultan, additional, Haider, Shariq, additional, Deuchar, Lesly, additional, LeBlanc, Brandi, additional, McCartney, Colin J.L., additional, Schemitsch, Emil H., additional, Vincent, Jessica, additional, Pettit, Shirley M., additional, Paul, James, additional, DuMerton, Deborah, additional, Paulin, Angela Djuric, additional, Simunovic, Marko, additional, Williams, David C., additional, Halman, Samantha, additional, Schlachta, Christopher M., additional, Shelley, Jessica, additional, Harlock, John, additional, Meyer, Ralph M., additional, Graham, Michelle, additional, Shanthanna, Harsha, additional, Parry, Neil, additional, Pichora, David R., additional, Yousef, Haroon, additional, Moloo, Husein, additional, Sehmbi, Herman, additional, Waggott, Melissa, additional, Belley-Cote, Emilie P., additional, Whitlock, Richard, additional, and Devereaux, P.J., additional
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- 2021
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31. ASSOCIATION BETWEEN HIGH-SENSITIVITY TROPONIN I AND MAJOR CARDIOVASCULAR EVENTS AFTER NON-CARDIAC SURGERY
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Duceppe, Emmanuelle, primary, Borges, Flavia K., additional, Tiboni, Maria, additional, Pearse, Rupert, additional, Chan, Matthew T.V., additional, Srinathan, Sadeesh, additional, Kavsak, Peter, additional, Szalay, David, additional, Garg, Amit, additional, Sessler, Daniel, additional, Sapsford, Robert, additional, Pettit, Shirley, additional, Vasquez, Javiera, additional, and Devereaux, P.J., additional
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- 2020
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32. Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial
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Borges, Flavia K, primary, Bhandari, Mohit, additional, Guerra-Farfan, Ernesto, additional, Patel, Ameen, additional, Sigamani, Alben, additional, Umer, Masood, additional, Tiboni, Maria E, additional, Villar-Casares, Maria del Mar, additional, Tandon, Vikas, additional, Tomas-Hernandez, Jordi, additional, Teixidor-Serra, Jordi, additional, Avram, Victoria RA, additional, Winemaker, Mitchell, additional, Ramokgopa, Mmampapatla T, additional, Szczeklik, Wojciech, additional, Landoni, Giovanni, additional, Wang, Chew Yin, additional, Begum, Dilshad, additional, Neary, John D, additional, Adili, Anthony, additional, Sancheti, Parag K, additional, Lawendy, Abdel-Rahman, additional, Balaguer-Castro, Mariano, additional, Ślęczka, Paweł, additional, Jenkinson, Richard J, additional, Nur, Aamer Nabi, additional, Wood, Gavin CA, additional, Feibel, Robert J, additional, McMahon, Stephen J, additional, Sigamani, Alen, additional, Popova, Ekaterine, additional, Biccard, Bruce M, additional, Moppett, Iain K, additional, Forget, Patrice, additional, Landais, Paul, additional, McGillion, Michael H, additional, Vincent, Jessica, additional, Balasubramanian, Kumar, additional, Harvey, Valerie, additional, Garcia-Sanchez, Yaiza, additional, Pettit, Shirley M, additional, Gauthier, Leslie P, additional, Guyatt, Gordon H, additional, Conen, David, additional, Garg, Amit X, additional, Bangdiwala, Shrikant I, additional, Belley-Cote, Emilie P, additional, Marcucci, Maura, additional, Lamy, Andre, additional, Whitlock, Richard, additional, Le Manach, Yannick, additional, Fergusson, Dean A, additional, Yusuf, Salim, additional, Devereaux, PJ, additional, Veevaete, Laurent, additional, le Polain de Waroux, Bernard, additional, Lavand'homme, Patricia, additional, Cornu, Olivier, additional, Tribak, Karim, additional, Yombi, Jean Cyr, additional, Touil, Nassim, additional, Reul, Maike, additional, Bhutia, Jigme Tshering, additional, Clinckaert, Carol, additional, De Clippeleir, Dirk, additional, de Beer, Justin, additional, Simpson, Diane L, additional, Worster, Andrew, additional, Alvarado, Kim A, additional, Gregus, Krysten K, additional, Lawrence, Kelly H, additional, Leong, Darryl P, additional, Joseph, Philip G, additional, Magloire, Patrick, additional, Deheshi, Benjamin, additional, Bisland, Stuart, additional, Wood, Thomas J, additional, Tushinski, Daniel M, additional, Wilson, David AJ, additional, Kearon, Clive, additional, Cowan, David D, additional, Khanna, Vickas, additional, Zaki, Amna, additional, Farrell, Janet C, additional, MacDonald, Anne Marie, additional, Wong, Steven CW, additional, Karbassi, Arsha, additional, Wright, Douglas Steven, additional, Shanthanna, Harsha, additional, Coughlin, Ryan, additional, Khan, Moin, additional, Wikkerink, Spencer, additional, Quraishi, Faraaz A, additional, Kishta, Waleed, additional, Schemitsch, Emil, additional, Carey, Timothy, additional, Macleod, Mark D, additional, Sanders, David W, additional, Vasarhelyi, Edward, additional, Bartley, Debra, additional, Dresser, George K, additional, Tieszer, Christina, additional, Shadowitz, Steven, additional, Lee, Jacques S, additional, Choi, Stephen, additional, Kreder, Hans J, additional, Nousiainen, Markku, additional, Kunz, Monica R, additional, Tuazon, Ravianne, additional, Shrikumar, Mopina, additional, Ravi, Bheeshma, additional, Wasserstein, David, additional, Stephen, David JG, additional, Nam, Diane, additional, Henry, Patrick DG, additional, Mann, Stephen M, additional, Jaeger, Melanie T, additional, Sivilotti, Marco LA, additional, Smith, Christopher A, additional, Frank, Christopher C, additional, Grant, Heather, additional, Ploeg, Leone, additional, Yach, Jeff D, additional, Harrison, Mark M, additional, Campbell, Aaron R, additional, Bicknell, Ryan T, additional, Bardana, Davide D, additional, McIlquham, Katie, additional, Gallant, Catherine, additional, Halman, Samantha, additional, Thiruganasambandamoorth, Venkatesh, additional, Ruggiero, Sara, additional, Hadden, William J, additional, Chen, Brian P-J, additional, Coupal, Stephanie A, additional, McLean, Lisa M, additional, Shirali, Hemant R, additional, Haider, Syed Y, additional, Smith, Crystal A, additional, Watts, Evan, additional, Santone, David J, additional, Koo, Kevin, additional, Yee, Allan J, additional, Oyenubi, Ademilola N, additional, Nauth, Aaron, additional, Schemitsch, Emil H, additional, Daniels, Timothy R, additional, Ward, Sarah E, additional, Hall, Jeremy A, additional, Ahn, Henry, additional, Whelan, Daniel B, additional, Atrey, Amit, additional, Khoshbin, Amir, additional, Puskas, David, additional, Droll, Kurt, additional, Cullinan, Claude, additional, Payendeh, Jubin, additional, Lefrancois, Tina, additional, Mozzon, Lise, additional, Marion, Travis, additional, Jacka, Michael J, additional, Greene, James, additional, Menon, Matthew, additional, Stiegelmahr, Robert, additional, Dillane, Derek, additional, Irwin, Marleen, additional, Beaupre, Lauren, additional, Coles, Chad P, additional, Trask, Kelly, additional, MacDonald, Shelley, additional, Trenholm, J Andrew I, additional, Oxner, William, additional, Richardson, C Glen, additional, Dehghan, Niloofar, additional, Sadoughi, Mehdi, additional, Sharma, Achal, additional, White, Neil J, additional, Olivieri, Loretta, additional, Hunt, Stephen B, additional, Turgeon, Thomas R, additional, Bohm, Eric R, additional, Tran, Sarah, additional, Giilck, Stephen M, additional, Hupel, Tom, additional, Guy, Pierre, additional, O'Brien, Peter J, additional, Duncan, Andrew W, additional, Crawford, Gordon A, additional, Zhou, Junlin, additional, Zhao, Yanrui, additional, Liu, Yang, additional, Shan, Lei, additional, Wu, Anshi, additional, Muñoz, Juan Manuel, additional, Chaudier, Philippe, additional, Douplat, Marion, additional, Fessy, Michel Henri, additional, Piriou, Vincent, additional, Louboutin, Lucie, additional, David, Jean Stephane, additional, Friggeri, Arnaud, additional, Beroud, Sebastien, additional, Fayet, Jean Marie, additional, Leung, Frankie Ka Li, additional, Fang, Christian Xinshuo, additional, Yee, Dennis King Hang, additional, Sancheti, Parag Kantilal, additional, Pradhan, Chetan Vijay, additional, Patil, Atul Ashok, additional, Puram, Chetan Prabhakar, additional, Borate, Madhav Pandurang, additional, Kudrimoti, Kiran Bhalchandra, additional, Adhye, Bharati Anil, additional, Dongre, Himanshu Vijaykumar, additional, John, Bobby, additional, Abraham, Valsamma, additional, Pandey, Ritesh Arvind, additional, Rajkumar, Arti, additional, George, Preetha Elizabeth, additional, Stephen, Manesh, additional, Chandran, Nitheesh, additional, Ashraf, Mohammed, additional, Georgekutty, AM, additional, Sulthan, Ahamad Shaheel, additional, Adinarayanan, S, additional, Sharma, Deep, additional, Barnawal, Satish Prasad, additional, Swaminathan, Srinivasan, additional, Bidkar, Prasanna Udupi, additional, Mishra, Sandeep Kumar, additional, Menon, Jagdish, additional, M, Niranjan, additional, K, Varghese Zachariah, additional, Hiremath, Santosh Angad, additional, NC, Madhusudhan, additional, Jawali, Abhijit, additional, Gnanadurai, Kingsly Robert, additional, George, Carolin Elizabeth, additional, Maddipati, Tatarao, additional, KP, Mary KP, additional, Sharma, Vijay, additional, Farooque, Kamran, additional, Malhotra, Rajesh, additional, Mittal, Samarth, additional, Sawhney, Chavi, additional, Gupta, Babita, additional, Mathur, Purva, additional, Gamangati, Shivanand, additional, Tripathy, Vijaylaxmi, additional, Menon, Prem Haridas, additional, Dhillon, Mandeep S, additional, Chouhan, Devendra K, additional, Patil, Sharanu, additional, Narayan, Ravi, additional, Lal, Purushotham, additional, Bilchod, Prashanth Nabhirajappa, additional, Singh, Surya Udai, additional, Gattu, Uttam Vaidya, additional, Dashputra, Ravi Prabhakar, additional, Rahate, Prashant Vitthal, additional, Turiel, Maurizio, additional, De Blasio, Giuseppe, additional, Accetta, Riccardo, additional, Perazzo, Paolo, additional, Stella, Daniele, additional, Bonadies, Marika, additional, Colombo, Chiara, additional, Fozzato, Stefania, additional, Pino, Fabio, additional, Morelli, Ilaria, additional, Colnaghi, Eleonora, additional, Salini, Vincenzo, additional, Denaro, Giuseppe, additional, Beretta, Luigi, additional, Placella, Giacomo, additional, Giardina, Giuseppe, additional, Binda, Mirko, additional, Marcato, Anna, additional, Guzzetti, Luca, additional, Piccirillo, Fabio, additional, Cecconi, Maurizio, additional, Khor, HM, additional, Lai, Hou Yee, additional, Kumar, CS, additional, Chee, KH, additional, Loh, PS, additional, Tan, Kit Mun, additional, Singh, Simmrat, additional, Foo, Li Lian, additional, Prakasam, Komella, additional, Chaw, Sook Hui, additional, Lee, Meng-Li, additional, Ngim, Joanne HL, additional, Boon, Huck Wee, additional, Chin, Im Im, additional, Kleinlugtenbelt, Ydo V, additional, Landman, Ellie BM, additional, Flikweert, Elvira R, additional, Roerdink, Herbert W, additional, Brokelman, Roy B.G., additional, Elskamp-Meijerman, Hannie F, additional, Horst, Maarten R, additional, Cobben, Jan-Hein MG, additional, Anjum, Anila, additional, Hashmi, Pervaiz Mehmood, additional, Ahmed, Tashfeen, additional, Rashid, Haroon Ur, additional, Khattak, Mujahid Jamil, additional, Rashid, Rizwan Haroon, additional, Lakdawala, Riaz Hussain, additional, Noordin, Shahryar, additional, Juman, Naveed Muhammed, additional, Khan, Robyna Irshad, additional, Riaz, Muhammad Mehmood, additional, Bokhari, Syedah Saira, additional, Almas, Ayesha, additional, Wahab, Hussain, additional, Ali, Arif, additional, Khan, Hammad Naqi, additional, Khan, Eraj Khurshid, additional, Janjua, Kholood Abid, additional, Orakzai, Sajjad Hassan, additional, Khan, Abdus Salam, additional, Mustafa, Khawaja Junaid, additional, Sohail, Mian Amjad, additional, Umar, Muhammad, additional, Khan, Siddra Ahmed, additional, Ashraf, Muhammad, additional, Khan, Muhammad Kashif, additional, Shiraz, Muhammad, additional, Furgan, Ahmad, additional, Dąbek, Piotr, additional, Kumoń, Adam, additional, Satora, Wojciech, additional, Ambroży, Wojciech, additional, Święch, Mariusz, additional, Rycombel, Jacek, additional, Grzelak, Adrian, additional, Gucwa, Jaroslaw, additional, Machala, Waldemar, additional, Ramokgopa, Mmampapatla Thomas, additional, Firth, Gregory Bodley, additional, Karera, Mwalimu, additional, Fourtounas, Maria, additional, Singh, Virsen, additional, Biscardi, Anna, additional, Iqbal, Muhammad Nasir, additional, Campbell, Ryan Jonathan, additional, Maluleke, Matimba Lenny, additional, Moller, Carien, additional, Nhlapo, Lerato, additional, Maqungo, Sithombo, additional, Flint, Margot, additional, Nejthardt, Marcin B, additional, Chetty, Sean, additional, Naidoo, Rubendren, additional, Garrido Clua, Miriam, additional, Molero-Garcia, Vicente, additional, Minguell-Monyart, Joan, additional, Selga Marsa, Jordi, additional, Porcel-Vazquez, Juan A, additional, Andres-Peiro, Jose-Vicente, additional, Aguilar, Marc, additional, Mestre-Torres, Jaume, additional, Colomina, Maria J, additional, Guilabert, Patricia, additional, Paños Gozalo, M Luisa, additional, Abarca, Luis, additional, Martin, Nuria, additional, Usua, Gemma, additional, Martinez-Ripol, Pedro, additional, Gonzalez Posada, MA, additional, Lalueza-Broto, Pilar, additional, Sanchez-Raya, Judith, additional, Nuñez Camarena, Jorge, additional, Fraguas-Castany, Antoni, additional, Torner, Pere, additional, Jornet-Gibert, Monsant, additional, Serrano-Sanz, Jorge, additional, Cámara-Cabrera, Jaume, additional, Salomó-Domènech, Mònica, additional, Yela-Verdú, Christian, additional, Peig-Font, Anna, additional, Ricol, Laura, additional, Carreras-Castañer, Anna, additional, Martínez-Sañudo, Luis, additional, Herranz, Susana, additional, Feijoo-Massó, Carlos, additional, Sianes-Gallén, Mònica, additional, Castillón, Pablo, additional, Bernaus, Martí, additional, Quintas, Saioa, additional, Gómez, Olga, additional, Salvador, Jordi, additional, Abarca, Javiera, additional, Estrada, Cristina, additional, Novellas, Marga, additional, Torra, Mercè, additional, Dealbert, Alfred, additional, Macho, Oscar, additional, Ivanov, Alexia, additional, Valldosera, Esther, additional, Arroyo, Marta, additional, Pey, Borja, additional, Yuste, Antoni, additional, Mateo, Llorenç, additional, De Caso, Julio, additional, Anaya, Rafael, additional, Higa-Sansone, JL, additional, Millan, Angelica, additional, Baños, Victoria, additional, Herrera-Mateo, Sergio, additional, Aguado, Hector J, additional, Martinez-Municio, Gonzalo, additional, León, Ricardo, additional, Santiago-Maniega, Silvia, additional, Zabalza, Ana, additional, Labrador, Gregorio, additional, Guerado, Enrique, additional, Cruz, Encarnacion, additional, Cano, Juan Ramon, additional, Bogallo, Jose Manuel, additional, Sa-ngasoongsong, Paphon, additional, Kulachote, Noratep, additional, Sirisreetreerux, Norachart, additional, Pengrung, Nachapan, additional, Chalacheewa, Theerawat, additional, Arnuntasupakul, Vanlapa, additional, Yingchoncharoen, Teerapat, additional, Naratreekoon, Bundit, additional, Kadry, Miriam Adel, additional, Thayaparan, Surendini, additional, Abdlaziz, Ihab, additional, Aframian, Arash, additional, Imbuldeniya, Arjuna, additional, Bentoumi, Souad, additional, Omran, Sherif, additional, Vizcaychipi, Marcela Paola, additional, Correia, Patricia, additional, Patil, Shashank, additional, Haire, Kevin, additional, Mayor, Amy SE, additional, Dillingham, Sally, additional, Nicholson, Laura, additional, Elnaggar, Mohamed, additional, John, Joby, additional, Nanjayan, Shashi Kumar, additional, Parker, Martyn J, additional, O'Sullivan, Susan, additional, Marmor, Meir T, additional, Matityahu, Amir, additional, McClellan, Robert Trigg, additional, Comstock, Curt, additional, Ding, Anthony, additional, Toogood, Paul, additional, Slobogean, Gerard, additional, Joseph, Katherine, additional, O'Toole, Robert, additional, Sciadini, Marcus, additional, Ryan, Scott P, additional, Clark, Molly E, additional, Cassidy, Charles, additional, Balonov, Konstantin, additional, Bergese, Sergio D, additional, Phieffer, Laura S, additional, Gonzalez Zacarias, Alicia A, additional, Marcantonio, Andrew J, additional, Borges, Flavia K, additional, Dragic-Taylor, Sanela, additional, Maxwell, Chelsea, additional, Molnar, Sarah, additional, Wells, Jennifer R, additional, Ofori, Sandra N, additional, Yang, Stephen S, additional, Wang, Michael K, additional, Duceppe, Emmanuelle, additional, Spence, Jessica, additional, Vasquez, Javiera P, additional, Marcano-Fernández, Francesc, additional, Ham, Hyungjoo, additional, Prada, Carlos, additional, Yung, Terence CH, additional, Sanz Pérez, Isidro, additional, Bosch, Michael J, additional, Prystajecky, Michael R, additional, Chowdhury, Chinmoy, additional, Khan, James S, additional, Stella, Steffan F, additional, Heidary, Behrouz, additional, Tran, Allen, additional, Wawrzycka-Adamczyk, Katarzyna, additional, Chen, Yu Chiao Peter, additional, González-Osuna, Aránzazu, additional, Biedroń, Grzegorz, additional, Wludarczyk, Anna, additional, Lefebvre, Marco, additional, Ernst, Jaclyn A, additional, Staffhorst, Bas, additional, Woodfine, Jason D, additional, Alwafi, Emad M, additional, Mrkobrada, Marko, additional, Parlow, Simon, additional, Roberts, Robin, additional, McAlister, Finlay, additional, Sackett, David, additional, and Wright, James, additional
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- 2020
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33. Patient preferences of the timing, number and duration of surgeon in-hospital visits on orthopaedic surgery and neurosurgery wards
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Bhandari, Mohit, Sprague, Sheila, Williams, Dale, Pettit, Shirley, Moro, Jaydeep K, Hanson, Beate, and Reddy, Kesava
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- 2003
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34. Preoperative N-Terminal Pro–B-Type Natriuretic Peptide and Cardiovascular Events After Noncardiac Surgery
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Duceppe, Emmanuelle, primary, Patel, Ameen, additional, Chan, Matthew T.V., additional, Berwanger, Otavio, additional, Ackland, Gareth, additional, Kavsak, Peter A., additional, Rodseth, Reitze, additional, Biccard, Bruce, additional, Chow, Clara K., additional, Borges, Flavia K., additional, Guyatt, Gordon, additional, Pearse, Rupert, additional, Sessler, Daniel I., additional, Heels-Ansdell, Diane, additional, Kurz, Andrea, additional, Wang, Chew Yin, additional, Szczeklik, Wojciech, additional, Srinathan, Sadeesh, additional, Garg, Amit X., additional, Pettit, Shirley, additional, Sloan, Erin N., additional, Januzzi Jr., James L., additional, McQueen, Matthew, additional, Buse, Giovanna Lurati, additional, Mills, Nicholas L., additional, Zhang, Lin, additional, Sapsford, Robert, additional, Paré, Guillaume, additional, Walsh, Michael, additional, Whitlock, Richard, additional, Lamy, Andre, additional, Hill, Stephen, additional, Thabane, Lehana, additional, Yusuf, Salim, additional, and Devereaux, P.J., additional
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- 2019
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35. Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture: a substudy protocol of the hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) international randomised controlled trial
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Borges, Flavia K, primary, Devereaux, P J, additional, Cuerden, Meaghan, additional, Bhandari, Mohit, additional, Guerra-Farfán, Ernesto, additional, Patel, Ameen, additional, Sigamani, Alben, additional, Umer, Masood, additional, Neary, John, additional, Tiboni, Maria, additional, Tandon, Vikas, additional, Ramokgopa, Mmampapatla Thomas, additional, Sancheti, Parag, additional, John, Bobby, additional, Lawendy, AbdelRahman, additional, Balaguer-Castro, Mariano, additional, Jenkinson, Richard, additional, Ślęczka, Paweł, additional, Nabi Nur, Aamer, additional, Wood, Gavin C A, additional, Feibel, Robert, additional, McMahon, John Stephen, additional, Sigamani, Alen, additional, Biccard, Bruce M, additional, Landoni, Giovanni, additional, Szczeklik, Wojciech, additional, Wang, Chew Yin, additional, Tomas-Hernandez, Jordi, additional, Abraham, Valsa, additional, Vincent, Jessica, additional, Harvey, Valerie, additional, Pettit, Shirley, additional, Sontrop, Jessica, additional, and Garg, Amit X, additional
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- 2019
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36. Rationale and design of the HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) Trial: a protocol for an international randomised controlled trial evaluating early surgery for hip fracture patients
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Borges, Flavia K, primary, Bhandari, Mohit, additional, Patel, Ameen, additional, Avram, Victoria, additional, Guerra-Farfán, Ernesto, additional, Sigamani, Alben, additional, Umer, Masood, additional, Tiboni, Maria, additional, Adili, Anthony, additional, Neary, John, additional, Tandon, Vikas, additional, Sancheti, Parag K, additional, Lawendy, AbdelRahman, additional, Jenkinson, Richard, additional, Ramokgopa, Mmampapatla, additional, Biccard, Bruce M, additional, Szczeklik, Wojciech, additional, Wang, Chew Yin, additional, Landoni, Giovanni, additional, Forget, Patrice, additional, Popova, Ekaterine, additional, Wood, Gavin, additional, Nabi Nur, Aamer, additional, John, Bobby, additional, Ślęczka, Paweł, additional, Feibel, Robert J, additional, Balaguer-Castro, Mariano, additional, Deheshi, Benjamin, additional, Winemaker, Mitchell, additional, de Beer, Justin, additional, Kolesar, Richard, additional, Teixidor-Serra, Jordi, additional, Tomas-Hernandez, Jordi, additional, McGillion, Michael, additional, Shanthanna, Harsha, additional, Moppett, Iain, additional, Vincent, Jessica, additional, Pettit, Shirley, additional, Harvey, Valerie, additional, Gauthier, Leslie, additional, Alvarado, Kim, additional, and Devereaux, P J, additional
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- 2019
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37. Independent Reading in the Sixth Grade: Free Choice and Access to Material.
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Coy-Shaffer, Joye and Pettit, Shirley
- Abstract
A study conducted in the Orange County Public Schools in central Florida investigated the reading interests of sixth-grade students. The study also gathered information from teachers regarding the nature and source of reading materials used for independent reading in their classrooms and on the implementation of sustained silent reading practices. Thirty-seven reading teachers completed a two-page survey, and 279 students completed a one-page survey. Results showed that students were most interested in mysteries, adventure, and "scary" stories. Favorite authors were Judy Blume, Beverly Cleary, and Stephen King. Teachers reported that independent reading is a significant part of the sixth-grade reading program. The study revealed, however, that approximately 48% of the teachers provided half or more of the materials used during independent reading periods from personal funds. Recommendations include several suggestions for strengthening an independent reading program. (Copies of the student survey and the teacher survey are attached.) (SR)
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- 1989
38. Rationale and design for the detection and neurological impact of cerebrovascular events in non-cardiac surgery patients cohort evaluation (NeuroVISION) study: a prospective international cohort study
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Mrkobrada, Marko, primary, Chan, Matthew T V, additional, Cowan, David, additional, Spence, Jessica, additional, Campbell, Douglas, additional, Wang, Chew Yin, additional, Torres, David, additional, Malaga, German, additional, Sanders, Robert D, additional, Brown, Carl, additional, Sigamani, Alben, additional, Szczeklik, Wojciech, additional, Dmytriw, Adam Andrew, additional, Agid, Ronit, additional, Smith, Eric E, additional, Hill, Michael D, additional, Sharma, Manas, additional, Sharma, Mukul, additional, Tsai, Scott, additional, Mensinkai, Arun, additional, Sahlas, Demetrios J, additional, Guyatt, Gordon, additional, Pettit, Shirley, additional, Copland, Ingrid, additional, Wu, William K K, additional, Yu, Simon C H, additional, Gin, Tony, additional, Loh, Pui San, additional, Ramli, Norlisah, additional, Siow, Yee Lein, additional, Short, Timothy G, additional, Waymouth, Ellen, additional, Kumar, Jonathan, additional, Dasgupta, Monidipa, additional, Murkin, John M, additional, Fuentes, Maite, additional, Ortiz-Soriano, Victor, additional, Lindroth, Heidi, additional, Simpson, Sara, additional, Sessler, Daniel, additional, and Devereaux, P J, additional
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- 2018
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39. Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE):an international, randomised, placebo-controlled trial
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Devereaux, P J, Duceppe, Emmanuelle, Guyatt, Gordon, Tandon, Vikas, Rodseth, Reitze, Biccard, Bruce M, Xavier, Denis, Szczeklik, Wojciech, Meyhoff, Christian S, Vincent, Jessica, Franzosi, Maria Grazia, Srinathan, Sadeesh K, Erb, Jason, Magloire, Patrick, Neary, John, Rao, Mangala, Rahate, Prashant V, Chaudhry, Navneet K, Mayosi, Bongani, de Nadal, Miriam, Iglesias, Pilar Paniagua, Berwanger, Otavio, Villar, Juan Carlos, Botto, Fernando, Eikelboom, John W, Sessler, Daniel I, Kearon, Clive, Pettit, Shirley, Sharma, Mukul, Connolly, Stuart J, Bangdiwala, Shrikant I, Rao-Melacini, Purnima, Hoeft, Andreas, Yusuf, Salim, Devereaux, P J, Duceppe, Emmanuelle, Guyatt, Gordon, Tandon, Vikas, Rodseth, Reitze, Biccard, Bruce M, Xavier, Denis, Szczeklik, Wojciech, Meyhoff, Christian S, Vincent, Jessica, Franzosi, Maria Grazia, Srinathan, Sadeesh K, Erb, Jason, Magloire, Patrick, Neary, John, Rao, Mangala, Rahate, Prashant V, Chaudhry, Navneet K, Mayosi, Bongani, de Nadal, Miriam, Iglesias, Pilar Paniagua, Berwanger, Otavio, Villar, Juan Carlos, Botto, Fernando, Eikelboom, John W, Sessler, Daniel I, Kearon, Clive, Pettit, Shirley, Sharma, Mukul, Connolly, Stuart J, Bangdiwala, Shrikant I, Rao-Melacini, Purnima, Hoeft, Andreas, and Yusuf, Salim
- Abstract
BACKGROUND: Myocardial injury after non-cardiac surgery (MINS) increases the risk of cardiovascular events and deaths, which anticoagulation therapy could prevent. Dabigatran prevents perioperative venous thromboembolism, but whether this drug can prevent a broader range of vascular complications in patients with MINS is unknown. The MANAGE trial assessed the potential of dabigatran to prevent major vascular complications among such patients.METHODS: In this international, randomised, placebo-controlled trial, we recruited patients from 84 hospitals in 19 countries. Eligible patients were aged at least 45 years, had undergone non-cardiac surgery, and were within 35 days of MINS. Patients were randomly assigned (1:1) to receive dabigatran 110 mg orally twice daily or matched placebo for a maximum of 2 years or until termination of the trial and, using a partial 2-by-2 factorial design, patients not taking a proton-pump inhibitor were also randomly assigned (1:1) to omeprazole 20 mg once daily, for which results will be reported elsewhere, or matched placebo to measure its effect on major upper gastrointestinal complications. Research personnel randomised patients through a central 24 h computerised randomisation system using block randomisation, stratified by centre. Patients, health-care providers, data collectors, and outcome adjudicators were masked to treatment allocation. The primary efficacy outcome was the occurrence of a major vascular complication, a composite of vascular mortality and non-fatal myocardial infarction, non-haemorrhagic stroke, peripheral arterial thrombosis, amputation, and symptomatic venous thromboembolism. The primary safety outcome was a composite of life-threatening, major, and critical organ bleeding. Analyses were done according to the intention-to-treat principle. This trial is registered with ClinicalTrials.gov, number NCT01661101.FINDINGS: Between Jan 10, 2013, and July 17, 2017, we randomly assigned 1754 patients t
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- 2018
40. Five-Year Outcomes after Off-Pump or On-Pump Coronary-Artery Bypass Grafting
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Lamy, André, Devereaux, PJ, Prabhakaran, Dorairaj, Taggart, David P, Hu, Shengshou, Straka, Zbynek, Piegas, Leopoldo S, Avezum, Alvaro, Akar, Ahmet R, Lanas Zanetti, Fernando, Jain, Anil R, Noiseux, Nicolas, Padmanabhan, Chandrasekar, Bahamondes, Juan-Carlos, Novick, Richard J, Tao, Liang, Olavegogeascoechea, Pablo A, Airan, Balram, Sulling, Toomas-Andres, Whitlock, Richard P, Ou, Yongning, Gao, Peggy, Pettit, Shirley, Yusuf, Salim, and CORONARY Investigators
- Abstract
BACKGROUND: We previously reported that there was no significant difference at 30 days or at 1 year in the rate of the composite outcome of death, stroke, myocardial infarction, or renal failure between patients who underwent coronary-artery bypass grafting (CABG) performed with a beating-heart technique (off-pump) and those who underwent CABG performed with cardiopulmonary bypass (on-pump). We now report the results at 5 years (the end of the trial). METHODS: A total of 4752 patients (from 19 countries) who had coronary artery disease were randomly assigned to undergo off-pump or on-pump CABG. For this report, we analyzed a composite outcome of death, stroke, myocardial infarction, renal failure, or repeat coronary revascularization (either CABG or percutaneous coronary intervention). The mean follow-up period was 4.8 years. RESULTS: There were no significant differences between the off-pump group and the on-pump group in the rate of the composite outcome (23.1% and 23.6%, respectively; hazard ratio with off-pump CABG, 0.98; 95% confidence interval [CI], 0.87 to 1.10; P=0.72) or in the rates of the components of the outcome, including repeat coronary revascularization, which was performed in 2.8% of the patients in the off-pump group and in 2.3% of the patients in the on-pump group (hazard ratio, 1.21; 95% CI, 0.85 to 1.73; P=0.29). The secondary outcome for the overall period of the trial - the mean cost in U.S. dollars per patient - also did not differ significantly between the off-pump group and the on-pump group ($15,107 and $14,992, respectively; between-group difference, $115; 95% CI, -$697 to $927). There were no significant between-group differences in quality-of-life measures. CONCLUSIONS: In our trial, the rate of the composite outcome of death, stroke, myocardial infarction, renal failure, or repeat revascularization at 5 years of follow-up was similar among patients who underwent off-pump CABG and those who underwent on-pump CABG. (Funded by the Canadian Institutes of Health Research; CORONARY ClinicalTrials.gov number, NCT00463294 .).
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- 2016
41. Colchicine for Prevention of Perioperative Atrial Fibrillation in patients undergoing lung resection surgery: a pilot randomized controlled study
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Bessissow, Amal, primary, Agzarian, John, additional, Shargall, Yaron, additional, Srinathan, Sadeesh, additional, Neary, John, additional, Tandon, Vikas, additional, Finley, Christian, additional, Healey, Jeff S, additional, Conen, David, additional, Rodseth, Reitze, additional, Pettit, Shirley, additional, Dechert, William, additional, Regalado, Otto, additional, Ramasundarahettige, Chinthanie, additional, Alshalash, Saleh, additional, and Devereaux, P J, additional
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- 2017
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42. Preoperative N-Terminal Pro-B-Type Natriuretic Peptide and Cardiovascular Events After Noncardiac Surgery: A Cohort Study.
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Duceppe, Emmanuelle, Patel, Ameen, Chan, Matthew T.V., Berwanger, Otavio, Ackland, Gareth, Kavsak, Peter A., Rodseth, Reitze, Biccard, Bruce, Chow, Clara K., Borges, Flavia K., Guyatt, Gordon, Pearse, Rupert, Sessler, Daniel I., Heels-Ansdell, Diane, Kurz, Andrea, Wang, Chew Yin, Szczeklik, Wojciech, Srinathan, Sadeesh, Garg, Amit X., and Pettit, Shirley
- Subjects
CARDIOVASCULAR diseases ,CARDIOVASCULAR surgery ,BRAIN natriuretic factor ,COHORT analysis ,SURGERY ,LONGITUDINAL method - Abstract
Background: Preliminary data suggest that preoperative N-terminal pro-B-type natriuretic peptide (NT-proBNP) may improve risk prediction in patients undergoing noncardiac surgery.Objective: To determine whether preoperative NT-proBNP has additional predictive value beyond a clinical risk score for the composite of vascular death and myocardial injury after noncardiac surgery (MINS) within 30 days after surgery.Design: Prospective cohort study.Setting: 16 hospitals in 9 countries.Patients: 10 402 patients aged 45 years or older having inpatient noncardiac surgery.Measurements: All patients had NT-proBNP levels measured before surgery and troponin T levels measured daily for up to 3 days after surgery.Results: In multivariable analyses, compared with preoperative NT-proBNP values less than 100 pg/mL (the reference group), those of 100 to less than 200 pg/mL, 200 to less than 1500 pg/mL, and 1500 pg/mL or greater were associated with adjusted hazard ratios of 2.27 (95% CI, 1.90 to 2.70), 3.63 (CI, 3.13 to 4.21), and 5.82 (CI, 4.81 to 7.05) and corresponding incidences of the primary outcome of 12.3% (226 of 1843), 20.8% (542 of 2608), and 37.5% (223 of 595), respectively. Adding NT-proBNP thresholds to clinical stratification (that is, the Revised Cardiac Risk Index [RCRI]) resulted in a net absolute reclassification improvement of 258 per 1000 patients. Preoperative NT-proBNP values were also statistically significantly associated with 30-day all-cause mortality (less than 100 pg/mL [incidence, 0.3%], 100 to less than 200 pg/mL [incidence, 0.7%], 200 to less than 1500 pg/mL [incidence, 1.4%], and 1500 pg/mL or greater [incidence, 4.0%]).Limitation: External validation of the identified NT-proBNP thresholds in other cohorts would reinforce our findings.Conclusion: Preoperative NT-proBNP is strongly associated with vascular death and MINS within 30 days after noncardiac surgery and improves cardiac risk prediction in addition to the RCRI.Primary Funding Source: Canadian Institutes of Health Research. [ABSTRACT FROM AUTHOR]- Published
- 2020
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43. Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery.
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Devereaux, P J, Biccard, Bruce M, Sigamani, Alben, Xavier, Denis, Chan, Matthew T V, Srinathan, Sadeesh K, Walsh, Michael, Abraham, Valsa, Pearse, Rupert, Wang, C Y, Sessler, Daniel I, Kurz, Andrea, Szczeklik, Wojciech, Berwanger, Otavio, Villar, Juan Carlos, Malaga, German, Garg, Amit X, Chow, Clara K, Ackland, Gareth, Patel, Ameen, Borges, Flavia Kessler, Belley-Cote, Emilie P, Duceppe, Emmanuelle, Spence, Jessica, Tandon, Vikas, Williams, Colin, Sapsford, Robert J, Polanczyk, Carisi A, Tiboni, Maria, Alonso-Coello, Pablo, Faruqui, Atiya, Heels-Ansdell, Diane, Lamy, Andre, Whitlock, Richard, LeManach, Yannick, Roshanov, Pavel S, McGillion, Michael, Kavsak, Peter, McQueen, Matthew J, Thabane, Lehana, Rodseth, Reitze N, Buse, Giovanna A Lurati, Bhandari, Mohit, Garutti, Ignacia, Jacka, Michael J, Schünemann, Holger J, Cortes, Olga Lucía, Coriat, Pierre, Dvirnik, Nazari, Botto, Fernando, Pettit, Shirley, Jaffe, Allan S, Guyatt, Gordon H, Devereaux, P J, Biccard, Bruce M, Sigamani, Alben, Xavier, Denis, Chan, Matthew T V, Srinathan, Sadeesh K, Walsh, Michael, Abraham, Valsa, Pearse, Rupert, Wang, C Y, Sessler, Daniel I, Kurz, Andrea, Szczeklik, Wojciech, Berwanger, Otavio, Villar, Juan Carlos, Malaga, German, Garg, Amit X, Chow, Clara K, Ackland, Gareth, Patel, Ameen, Borges, Flavia Kessler, Belley-Cote, Emilie P, Duceppe, Emmanuelle, Spence, Jessica, Tandon, Vikas, Williams, Colin, Sapsford, Robert J, Polanczyk, Carisi A, Tiboni, Maria, Alonso-Coello, Pablo, Faruqui, Atiya, Heels-Ansdell, Diane, Lamy, Andre, Whitlock, Richard, LeManach, Yannick, Roshanov, Pavel S, McGillion, Michael, Kavsak, Peter, McQueen, Matthew J, Thabane, Lehana, Rodseth, Reitze N, Buse, Giovanna A Lurati, Bhandari, Mohit, Garutti, Ignacia, Jacka, Michael J, Schünemann, Holger J, Cortes, Olga Lucía, Coriat, Pierre, Dvirnik, Nazari, Botto, Fernando, Pettit, Shirley, Jaffe, Allan S, and Guyatt, Gordon H
- Abstract
Little is known about the relationship between perioperative high-sensitivity troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac surgery (MINS). To determine the association between perioperative hsTnT measurements and 30-day mortality and potential diagnostic criteria for MINS (ie, myocardial injury due to ischemia associated with 30-day mortality). Prospective cohort study of patients aged 45 years or older who underwent inpatient noncardiac surgery and had a postoperative hsTnT measurement. Starting in October 2008, participants were recruited at 23 centers in 13 countries; follow-up finished in December 2013. Patients had hsTnT measurements 6 to 12 hours after surgery and daily for 3 days; 40.4% had a preoperative hsTnT measurement. A modified Mazumdar approach (an iterative process) was used to determine if there were hsTnT thresholds associated with risk of death and had an adjusted hazard ratio (HR) of 3.0 or higher and a risk of 30-day mortality of 3% or higher. To determine potential diagnostic criteria for MINS, regression analyses ascertained if postoperative hsTnT elevations required an ischemic feature (eg, ischemic symptom or electrocardiography finding) to be associated with 30-day mortality. Among 21 842 participants, the mean age was 63.1 (SD, 10.7) years and 49.1% were female. Death within 30 days after surgery occurred in 266 patients (1.2%; 95% CI, 1.1%-1.4%). Multivariable analysis demonstrated that compared with the reference group (peak hsTnT <5 ng/L), peak postoperative hsTnT levels of 20 to less than 65 ng/L, 65 to less than 1000 ng/L, and 1000 ng/L or higher had 30-day mortality rates of 3.0% (123/4049; 95% CI, 2.6%-3.6%), 9.1% (102/1118; 95% CI, 7.6%-11.0%), and 29.6% (16/54; 95% CI, 19.1%-42.8%), with corresponding adjusted HRs of 23.63 (95% CI, 10.32-54.09), 70.34 (95% CI, 30.60-161.71), and 227.01 (95% CI, 87.35-589.92), respectively. An absolute hsTnT change of 5 ng/L or higher was associated wi
- Published
- 2017
44. Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery
- Author
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Devereaux, P.J., Biccard, Bruce M., Sigamani, Alben, Xavier, Denis, Chan, Matthew T. V., Srinathan, Sadeesh K., Walsh, Michael, Abraham, Valsa, Pearse, Rupert, Wang, Y., Sessler, Daniel I., Kurz, Andrea, Szczeklik, Wojciech, Berwanger, Otavio, Villar, Juan Carlos, Malaga, German, Garg, Amit X., Chow, Clara K., Ackland, Gareth, Patel, Ameen, Kessler Borges, Flavia, Belley-Cote, Emilie P., Duceppe, Emmanuelle, Spence, Jessica, Tandon, Vikas, Williams, Colin, Sapsford, Robert J., Polanczyk, Carisi A., Tiboni, Maria, Alonso-Coello, Pablo, Faruqui, Atiya, Heels-Ansdell, Diane, Lamy, Andre, Whitlock, Richard, LeManach, Yannick, Roshanov, Pavel S., McGillion, Michael, Kavsak, Peter, McQueen, Matthew J., Thabane, Lehana, Rodseth, Reitze N., Lurati Buse, Giovanna A., Bhandari, Mohit, Garutti, Ignacia, Jacka, Michael J., Schunemann, Holger J., Cortes, Olga Lucia, Coriat, Pierre, Dvirnik, Nazari, Botto, Fernando, Pettit, Shirley, Jaffe, Allan S., Guyatt, Gordon H., and VISION Study Investigators
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Male ,Myocardial Ischemia/mortality ,Myocardial Infarction ,Myocardial Ischemia ,030204 cardiovascular system & hematology ,Risk Assessment ,Preoperative care ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Troponin T ,030202 anesthesiology ,medicine ,Humans ,Prospective Studies ,Postoperative Period ,Myocardial infarction ,Prospective cohort study ,Myocardial Infarction/mortality ,Aged ,Troponin T/blood ,medicine.diagnostic_test ,business.industry ,Hazard ratio ,General Medicine ,Perioperative ,Middle Aged ,medicine.disease ,purl.org/pe-repo/ocde/ford#3.02.00 [https] ,Editorial ,Anesthesia ,Female ,Risk assessment ,business ,Electrocardiography - Abstract
IMPORTANCE Little is known about the relationship between perioperative high-sensitivity troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac surgery (MINS). OBJECTIVE To determine the association between perioperative hsTnT measurements and 30-day mortality and potential diagnostic criteria for MINS (ie, myocardial injury due to ischemia associated with 30-day mortality). DESIGN, SETTING, AND PARTICIPANTS Prospective cohort study of patients aged 45 years or older who underwent inpatient noncardiac surgery and had a postoperative hsTnT measurement. Starting in October 2008, participants were recruited at 23 centers in 13 countries; follow-up finished in December 2013. EXPOSURES Patients had hsTnT measurements 6 to 12 hours after surgery and daily for 3 days; 40.4% had a preoperative hsTnT measurement. MAIN OUTCOMES AND MEASURES A modified Mazumdar approach (an iterative process) was used to determine if there were hsTnT thresholds associated with risk of death and had an adjusted hazard ratio (HR) of 3.0 or higher and a risk of 30-day mortality of 3% or higher. To determine potential diagnostic criteria for MINS, regression analyses ascertained if postoperative hsTnT elevations required an ischemic feature (eg, ischemic symptom or electrocardiography finding) to be associated with 30-day mortality. RESULTS Among 21 842 participants, the mean age was 63.1 (SD, 10.7) years and 49.1% were female. Death within 30 days after surgery occurred in 266 patients (1.2%; 95% CI, 1.1%-1.4%). Multivariable analysis demonstrated that compared with the reference group (peak hsTnT = 5 ng/L or hsTnT >= 65 ng/L) without an ischemic feature was associated with 30-day mortality (adjusted HR, 3.20; 95% CI, 2.37-4.32). Among the 3904 patients (17.9%; 95% CI, 17.4%-18.4%) with MINS, 3633 (93.1%; 95% CI, 92.2%-93.8%) did not experience an ischemic symptom. CONCLUSIONS AND RELEVANCE Among patients undergoing noncardiac surgery, peak postoperative hsTnT during the first 3 days after surgery was significantly associated with 30-day mortality. Elevated postoperative hsTnT without an ischemic feature was also associated with 30-day mortality.
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- 2017
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45. Technology-Enabled Remote Monitoring and Self-Management — Vision for Patient Empowerment Following Cardiac and Vascular Surgery: User Testing and Randomized Controlled Trial Protocol
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McGillion, Michael, primary, Yost, Jennifer, additional, Turner, Andrew, additional, Bender, Duane, additional, Scott, Ted, additional, Carroll, Sandra, additional, Ritvo, Paul, additional, Peter, Elizabeth, additional, Lamy, Andre, additional, Furze, Gill, additional, Krull, Kirsten, additional, Dunlop, Valerie, additional, Good, Amber, additional, Dvirnik, Nazari, additional, Bedini, Debbie, additional, Naus, Frank, additional, Pettit, Shirley, additional, Henry, Shaunattonie, additional, Probst, Christine, additional, Mills, Joseph, additional, Gossage, Elaine, additional, Travale, Irene, additional, Duquette, Janine, additional, Taberner, Christy, additional, Bhavnani, Sanjeev, additional, Khan, James S, additional, Cowan, David, additional, Romeril, Eric, additional, Lee, John, additional, Colella, Tracey, additional, Choinière, Manon, additional, Busse, Jason, additional, Katz, Joel, additional, Victor, J Charles, additional, Hoch, Jeffrey, additional, Isaranuwatchai, Wanrudee, additional, Kaasalainen, Sharon, additional, Ladak, Salima, additional, O'Keefe-McCarthy, Sheila, additional, Parry, Monica, additional, Sessler, Daniel I, additional, Stacey, Michael, additional, Stevens, Bonnie, additional, Stremler, Robyn, additional, Thabane, Lehana, additional, Watt-Watson, Judy, additional, Whitlock, Richard, additional, MacDermid, Joy C, additional, Leegaard, Marit, additional, McKelvie, Robert, additional, Hillmer, Michael, additional, Cooper, Lynn, additional, Arthur, Gavin, additional, Sider, Krista, additional, Oliver, Susan, additional, Boyajian, Karen, additional, Farrow, Mark, additional, Lawton, Chris, additional, Gamble, Darryl, additional, Walsh, Jake, additional, Field, Mark, additional, LeFort, Sandra, additional, Clyne, Wendy, additional, Ricupero, Maria, additional, Poole, Laurie, additional, Russell-Wood, Karsten, additional, Weber, Michael, additional, McNeil, Jolene, additional, Alpert, Robyn, additional, Sharpe, Sarah, additional, Bhella, Sue, additional, Mohajer, David, additional, Ponnambalam, Sem, additional, Lakhani, Naeem, additional, Khan, Rabia, additional, Liu, Peter, additional, and Devereaux, PJ, additional
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- 2016
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46. Myocardial Injury after Noncardiac Surgery : a Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes
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Surgery Patients Cohort Evaluation, Vascular Events In Noncardiac, Botto, Fernando, Alonso-Coello, Pablo, Chan, Matthew T. V., Villar, Juan Carlos, Xavier, Denis, Srinathan, Sadeesh, Guyatt, Gordon H., Cruz, Patricia, Graham, Michelle, Berwanger, Otavio, Pearse, Rupert M., Biccard, Bruce M., Abraham, Valsa, Malaga, German, Hillis, Graham S., Rodseth, Reitze N., Cook, Deborah, Polanczyk, Carisi A., Szczeklik, Wojciech, Sessler, Daniel I., Sheth, Tej, Ackland, Gareth L., Leuwer, Martin, Garg, Amit X., LeManach, Yannick, Pettit, Shirley, Heels-Ansdell, Diane, LuratiBuse, Giovanna, Walsh, Michael, Sapsford, Robert, Schunemann, Holger J., Kurz, Andrea, Thomas, Sabu, Mrkobrada, Marko, Thabane, Lehana, Gerstein, Hertzel, Paniagua, Pilar, Nagele, Peter, Raina, Parminder, Yusuf, Salim, and Devereaux, P.-J.
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- 2014
47. Colchicine for Prevention of Perioperative Atrial Fibrillation in patients undergoing lung resection surgery: a pilot randomized controlled study.
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Bessissow, Amal, Agzarian, John, Shargall, Yaron, Srinathan, Sadeesh, Neary, John, Tandon, Vikas, Finley, Christian, Healey, Jeff S., Conen, David, Rodseth, Reitze, Pettit, Shirley, Decherti, William, Regalado, Otto, Ramasundarahettige, Chinthanie, Alshalash, Saleh, and Devereaux, P. J.
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ATRIAL fibrillation ,COLCHICINE ,LUNG surgery ,THORACIC surgery ,PLACEBOS ,PATIENTS ,THERAPEUTICS - Abstract
OBJECTIVES: We carried out a pilot randomized controlled study to determine the feasibility of a large trial evaluating the impact of colchicine versus placebo on postoperative atrial fibrillation or atrial flutter (POAF) among patients undergoing lung resection surgery. METHODS: Patients >55 years of age undergoing lung resection surgery were randomly assigned to receive colchicine 0.6mg or placebo starting a few hours before surgery. Postoperatively, patients received colchicine 0.6mg or placebo twice daily for an additional 9 days. Our feasibility outcomes included the period of time required to recruit 100 patients, the completeness of follow-up and compliance with the study drug. The primary efficacy outcome was POAF within 30 days of randomization. RESULTS: One hundred patients were randomized (49 to colchicine and 51 to placebo) over a period of 12 months at 2 centres in Canada. All patients completed the 30-day follow-up. The mean staff time required to recruit and to follow-up each patient was 165 min. In all, 71% of patients completed the study drug course without interruption. Patient refusal to continuing taking the study drug was the main reason for permanent drug discontinuation. New POAF occurred in 5 (10.2%) patients in the colchicine group and 7 (13.7%) patients in the placebo group (adjusted hazard ratio 0.69, 95% confidence interval 0.20–2.34). CONCLUSIONS: These results show the feasibility of a trial evaluating Colchicine for the prevention of perioperative Atrial Fibrillation in patients undergoing lung resection surgery. This pilot study will serve as the foundation for the large multicentre COP-AF trial. [ABSTRACT FROM AUTHOR]
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- 2018
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48. The RADICAL-PC trial.
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Pinthus, Jehonathan H, primary, Klotz, Laurence, additional, Lukka, Himanshu, additional, Duivenvoorden, Wilhelmina CM, additional, Pettit, Shirley, additional, Pohl, Kayla, additional, Siemens, D. Robert, additional, Fradet, Vincent, additional, Mourtzakis, Marina, additional, Kavsac, Peter, additional, Devereaux, PJ, additional, and Leong, Darryl, additional
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- 2016
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49. High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study
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Kavsak, Peter A., Walsh, Mike, Srinathan, Sadeesh, Thorlacius, Laurel, Buse, Giovanna Lurati, Botto, Fernando, Pettit, Shirley, McQueen, Matthew J., Hill, Stephen A., Thomas, Sabu, Mrkobrada, Marko, Alonso-Coello, Pablo, Berwanger, Otavio, Biccard, Bruce M., Cembrowski, George, Chan, Matthew T.V., Chow, Clara K., de Miguel, Angeles, Garcia, Mercedes, Graham, Michelle M., Jacka, Michael J., Kueh, J.H., Li, Stephen C.H., Lit, Lydia C.W., Martínez-Brú, Cecília, Naidoo, Prebashini, Nagele, Peter, Pearse, Rupert M., Rodseth, Reitze N., Sessler, Daniel I., Sigamani, Alben, Szczeklik, Wojciech, Tiboni, Maria, Villar, Juan Carlos, Wang, C.Y., Xavier, Denis, and Devereaux, P.J.
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- 2011
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50. Aspirin in patients undergoing noncardiac surgery
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UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - (SLuc) Service d'anesthésiologie, Devereaux, P J, Mrkobrada, Marko, Sessler, Daniel I, Leslie, Kate, Alonso-Coello, Pablo, Kurz, Andrea, Villar, Juan Carlos, Sigamani, Alben, Biccard, Bruce M, Meyhoff, Christian S, Parlow, Joel L, Guyatt, Gordon, Robinson, Andrea, Garg, Amit X, Rodseth, Reitze N, Botto, Fernando, Lurati Buse, Giovanna, Xavier, Denis, Chan, Matthew T V, Tiboni, Maria, Cook, Deborah, Kumar, Priya A, Forget, Patrice, Malaga, German, Fleischmann, Edith, Amir, Mohammed, Eikelboom, John, Mizera, Richard, Torres, David, Wang, C Y, VanHelder, Tomas, Paniagua, Pilar, Berwanger, Otavio, Srinathan, Sadeesh, Graham, Michelle, Pasin, Laura, Le Manach, Yannick, Gao, Peggy, Pogue, Janice, Whitlock, Richard, Lamy, André, Kearon, Clive, Baigent, Colin, Chow, Clara, Pettit, Shirley, Chrolavicius, Susan, Yusuf, Salim, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - (SLuc) Service d'anesthésiologie, Devereaux, P J, Mrkobrada, Marko, Sessler, Daniel I, Leslie, Kate, Alonso-Coello, Pablo, Kurz, Andrea, Villar, Juan Carlos, Sigamani, Alben, Biccard, Bruce M, Meyhoff, Christian S, Parlow, Joel L, Guyatt, Gordon, Robinson, Andrea, Garg, Amit X, Rodseth, Reitze N, Botto, Fernando, Lurati Buse, Giovanna, Xavier, Denis, Chan, Matthew T V, Tiboni, Maria, Cook, Deborah, Kumar, Priya A, Forget, Patrice, Malaga, German, Fleischmann, Edith, Amir, Mohammed, Eikelboom, John, Mizera, Richard, Torres, David, Wang, C Y, VanHelder, Tomas, Paniagua, Pilar, Berwanger, Otavio, Srinathan, Sadeesh, Graham, Michelle, Pasin, Laura, Le Manach, Yannick, Gao, Peggy, Pogue, Janice, Whitlock, Richard, Lamy, André, Kearon, Clive, Baigent, Colin, Chow, Clara, Pettit, Shirley, Chrolavicius, Susan, and Yusuf, Salim
- Abstract
BACKGROUND: There is substantial variability in the perioperative administration of aspirin in patients undergoing noncardiac surgery, both among patients who are already on an aspirin regimen and among those who are not. METHODS: Using a 2-by-2 factorial trial design, we randomly assigned 10,010 patients who were preparing to undergo noncardiac surgery and were at risk for vascular complications to receive aspirin or placebo and clonidine or placebo. The results of the aspirin trial are reported here. The patients were stratified according to whether they had not been taking aspirin before the study (initiation stratum, with 5628 patients) or they were already on an aspirin regimen (continuation stratum, with 4382 patients). Patients started taking aspirin (at a dose of 200 mg) or placebo just before surgery and continued it daily (at a dose of 100 mg) for 30 days in the initiation stratum and for 7 days in the continuation stratum, after which patients resumed their regular aspirin regimen. The primary outcome was a composite of death or nonfatal myocardial infarction at 30 days. RESULTS: The primary outcome occurred in 351 of 4998 patients (7.0%) in the aspirin group and in 355 of 5012 patients (7.1%) in the placebo group (hazard ratio in the aspirin group, 0.99; 95% confidence interval [CI], 0.86 to 1.15; P=0.92). Major bleeding was more common in the aspirin group than in the placebo group (230 patients [4.6%] vs. 188 patients [3.8%]; hazard ratio, 1.23; 95% CI, 1.01, to 1.49; P=0.04). The primary and secondary outcome results were similar in the two aspirin strata. CONCLUSIONS: Administration of aspirin before surgery and throughout the early postsurgical period had no significant effect on the rate of a composite of death or nonfatal myocardial infarction but increased the risk of major bleeding. (Funded by the Canadian Institutes of Health Research and others; POISE-2 ClinicalTrials.gov number, NCT01082874.).
- Published
- 2014
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