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2. P1345: IMMUNE RECONSTITUTION AFTER BMT FOR NON-MALIGNANT HEMATOLOGICAL CONDITIONS FOR RELATED, UNRELATED AND HAPLOIDENTICAL DONORS. A STUDY IN THE PEDIATRIC DEPARTMENT AT ST MARY’S HOSPITAL BETWEEN 2019&2020

Author

Khoder, A., primary, Gassas, A., additional, Bremathas, S., additional, Rabanal, O., additional, Hennesy, K., additional, Loaiza, S., additional, Lund, K., additional, Petterson, T., additional, Karnik, L., additional, and Josu de la Fuente, J., additional

Published
2022
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3. P656: INCIDENT VENOUS THROMBOEMBOLISM (VTE) IN PATIENTS WITH MONOCLONAL B-CELL LYMPHOCYTOSIS (MBL) AND CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) – A POPULATION-BASED STUDY

Author

Koehler, A., primary, Moise, M., additional, Call, T., additional, Rabe, K., additional, Achenbach, S., additional, Crusan, D., additional, Bailey, K., additional, Petterson, T., additional, Ding, W., additional, Kenderian, S., additional, Leis, J., additional, Wang, Y., additional, Muchtar, E., additional, Hampel, P., additional, Schwager, S., additional, Slager, S., additional, Kay, N., additional, Ashrani, A., additional, and Parikh, S., additional

Published
2022
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14. LDH based neonatal diagnostics on a low-cost slipdisc based sample preparation platform

Author

Banerjee, Indradumna, Salih, Tagrid, Ramachandraiah, Harisha, Erlandsson, J., Petterson, T., Silva, AC, Karlsson, M, and Russom, Aman

Subjects
Teknik och teknologier, Engineering and Technology
Abstract

INTRODUCTION Slipdisc is developed as a sample preparation platform based on slipchip technology [1], using a handwinded clockwork mechanism allowing sample processing from one spot to another with defined precision without the need for sophisticated tools or alignment (Fig.1). An ordinary smartphone or camera can be used to image and analyse the results making it an ideal tool for resource limited settings. Here, we demonstrate a bioassay for detecting LDH (Fig.2), a crucial enzyme found in all living cells which leaks out when the cellular membrane is damaged. This makes LDH a biomarker for several medical conditions in newborns, such as Ozkiraz-13, necrotizing enterocolitis (NEC), and Asphyxia. EXPERIMENTAL For assembling the slipdisc optically transparent, robust and disposable CD like polycarbonate discs were used with superhydrophobic coating on all except the embedded microfluidic channels. For the LDH assay, heparinized plasma samples were spiked with 7 different concentrations of the LDH enzyme (Lee Biosolutions, USA). These concentrations ranged from clinically normal to abnormal concentrations and used to construct a standard curve for LDH enzyme. RESULTS AND DISCUSSION The ability of the SlipDisc to quantify LDH enzyme levels from plasma samples was evaluated (Fig.3). Using 7 different concentrations, a standard curve with clinically relevant LDH concentrations was obtained (Fig4). Image and data analyses, including linear regression and Pearson’s correlation, were completed using Image processing tool in Matlab. CONCLUSION We demonstrate a low-cost neonatal diagnostics platform for the detection of LDH from plasma using a novel SlipDisc platform. The SlipDisc can further be modified to separate plasma from whole blood samples in order to fully integrate the assay. Its simple operation and smartphone based detection capabilities make it an ideal device for point-of-care neonatal diagnostics. QC 20190819

Published
2016

19. Morality and religion; A weakened relationship?

Author

Halman, L.C.J.M., Petterson, T., and TS Social and Behavioral Sciences

Subjects
religion, ComputingMilieux_LEGALASPECTSOFCOMPUTING, sociology and psychology, ethics, moral values
Published
1996

20. Outcome following unrelated cord blood transplant in 136 patients with malignant and non-malignant diseases: a report from the Australian and New Zealand children's haematology and oncology group

Author

Petterson, T E, primary, Gabriel, M, additional, Tiedemann, K, additional, Teague, L, additional, Shaw, P J, additional, Baker, D, additional, Bolton-Jones, R, additional, Tapp, H, additional, Oswald, C, additional, Vowels, M R, additional, and O'Brien, T A, additional

Published
2008
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21. Well-being and treatment satisfaction in older people with diabetes.

Author

Petterson, T., Lee, P., Hollis, S., Young, B., Newton, P., Dornan, T. L., Petterson, T., Lee, P., Hollis, S., Young, B., Newton, P., and Dornan, T. L.

Abstract

OBJECTIVE: To measure well-being and treatment satisfaction and their correlates in older people with diabetes. RESEARCH DESIGN AND METHODS: A postal survey was conducted of 1,000 diabetic patients aged > or = 60 years, representing 56% of the resident older diabetic population in an inner-city health district with a largely indigenous population of 230,000 people and a widely varied socioeconomic mix. Well-being and treatment satisfaction were measured with diabetes-specific instruments and correlated with patient data held in a central register. RESULTS: There was an 81% response. The general well-being scores (median [interquartile range]) for patients on diet alone, tablets, and insulin were 54 (44-60), 53 (42-61), and 48 (35-56) (P < 0.001 comparing insulin with diet and tablets) compared with a scale maximum of 66. Treatment satisfaction scores were 35 (31-36), 35 (32-36), and 34 (30-36) (P < 0.001 comparing insulin with diet and tablets), scale maximum 36. Mean HbA1c concentrations were 5.0 +/- 1.4% (for patients on diet alone), 5.8 +/- 1.6% (tablets), and 6.6 +/- 1.7% (insulin) (P < 0.001 for each difference). Neither well-being nor treatment satisfaction correlated with HbA1c. Insulin-treated patients were younger and had been diabetic longer than non-insulin-treated patients; their well-being remained slightly, but significantly, lower when adjusted for age, sex, BMI, and diabetes duration, but treatment satisfaction was no longer significantly different. Women had lower well-being than men. CONCLUSIONS: It has proved possible to measure well-being and treatment satisfaction in a large community-based samples of older people with diabetes. At the level of glycemic control in this population, neither parameter correlated with HbA1c. The lower well-being in insulin-treated patients remained significant in multivariate analysis.

Published
1998

22. Dyspepsia: endoscopy-guided tx, empiric therapy cost the same

Author

Silverstein, M.D., Petterson, T., and Talley, N.J.

Subjects
Indigestion -- Care and treatment, Endoscopy -- Evaluation, Antiulcer drugs -- Dosage and administration, Health, Seniors
Abstract

The cost of managing dyspepsia with empiric [H.sub.2] antagonist therapy or a treatment strategy guided by an initial endoscopy is about the same, according to these authors from the Mayo [...]

Published
1996

23. A randomized trial of intravenous immunoglobulin in inflammatory demyelinating optic neuritis

Author

Noseworthy, J. H., primary, O'Brien, P. C., additional, Petterson, T. M., additional, Weis, J., additional, Stevens, L., additional, Peterson, W. K., additional, Sneve, D., additional, Cross, S. A., additional, Leavitt, J. A., additional, Auger, R. G., additional, Weinshenker, B. G., additional, Dodick, D. W., additional, Wingerchuk, D. M., additional, and Rodriguez, M., additional

Published
2001
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24. IV immunoglobulin does not reverse established weakness in MS: A double-blind, placebo-controlled trial

Author

Noseworthy, J. H., primary, O'Brien, P. C., additional, Weinshenker, B. G., additional, Weis, J. A., additional, Petterson, T. M., additional, Erickson, B. J., additional, Windebank, A. J., additional, Whisnant, J. P., additional, Stolp-Smith, K. A., additional, Harper, C. M., additional, Low, P. A., additional, Romme, L. J., additional, Johnson, M., additional, An, K.-N., additional, and Rodriguez, M., additional

Published
2000
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38. The genetic background of tumour necrosis factor receptor-associated periodic syndrome and other systemic autoinflammatory disorders.

Author

Stjernberg-Salmela, S., Ranki, A., Karenko, L., Petterson, T., and Pettersson, T

Subjects
INFLAMMATION, FAMILIAL Mediterranean fever, GENETIC disorders, FAMILIAL diseases, TUMOR necrosis factors, IMMUNITY
Abstract

Systemic autoinflammatory disorders are hereditary diseases with symptoms of acute inflammation and a rise in serum acute phase proteins as a consequence, but with no signs of autoimmunity. By the end of the 1990s, four types of hereditary periodic fever had been described in the medical literature: familial Mediterranean fever, hyperimmunoglobulinemia D with periodic fever syndrome (HIDS), tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS) and Muckle-Wells syndrome. Since then, the number of diseases classified as systemic autoinflammatory disorders has increased to eight. In patients of Nordic descent, cases of HIDS and TRAPS have been reported. We provide an overview of the genetic background and main clinical aspects of the different autoinflammatory disorders, with an emphasis on TRAPS. [ABSTRACT FROM AUTHOR]

Published
2004

42. Well-being and treatment satisfaction in older people with diabetes.

Author

Petterson, T, Lee, P, Hollis, S, Young, B, Newton, P, and Dornan, T

Abstract

OBJECTIVE: To measure well-being and treatment satisfaction and their correlates in older people with diabetes. RESEARCH DESIGN AND METHODS: A postal survey was conducted of 1,000 diabetic patients aged > or = 60 years, representing 56% of the resident older diabetic population in an inner-city health district with a largely indigenous population of 230,000 people and a widely varied socioeconomic mix. Well-being and treatment satisfaction were measured with diabetes-specific instruments and correlated with patient data held in a central register. RESULTS: There was an 81% response. The general well-being scores (median [interquartile range]) for patients on diet alone, tablets, and insulin were 54 (44-60), 53 (42-61), and 48 (35-56) (P < 0.001 comparing insulin with diet and tablets) compared with a scale maximum of 66. Treatment satisfaction scores were 35 (31-36), 35 (32-36), and 34 (30-36) (P < 0.001 comparing insulin with diet and tablets), scale maximum 36. Mean HbA1c concentrations were 5.0 +/- 1.4% (for patients on diet alone), 5.8 +/- 1.6% (tablets), and 6.6 +/- 1.7% (insulin) (P < 0.001 for each difference). Neither well-being nor treatment satisfaction correlated with HbA1c. Insulin-treated patients were younger and had been diabetic longer than non-insulin-treated patients; their well-being remained slightly, but significantly, lower when adjusted for age, sex, BMI, and diabetes duration, but treatment satisfaction was no longer significantly different. Women had lower well-being than men. CONCLUSIONS: It has proved possible to measure well-being and treatment satisfaction in a large community-based samples of older people with diabetes. At the level of glycemic control in this population, neither parameter correlated with HbA1c. The lower well-being in insulin-treated patients remained significant in multivariate analysis.

Published
1998

44. Mucositis, conjunctivitis but no rash - the 'Atypical Stevens - Johnson syndrome'

Author

Dc, Mcgouran, Petterson T, Jm, Mclaren, and Mariusz Wolbinski

Subjects
Diagnosis, Differential, Male, Mucositis, Adolescent, Stevens-Johnson Syndrome, Mouth Mucosa, Humans, Exanthema, Conjunctivitis, Follow-Up Studies
Abstract

The Stevens-Johnson syndrome (SJS) classically involves a rash, conjunctivitis and mucositis. We describe the case of a young adult male with isolated mucositis and conjunctivitis . Previous rare reports of severe SJS like syndromes without a rash are confined to children, usually with mycoplasma pnemoniae infection.(1) Terminology for this syndrome includes - "Stevens-Johnson Syndrome without skin lesions", or "Atypical Stevens - Johnson Syndrome".(2) This case highlights the importance of maintaining an open mind when a "full house" of clinical features is absent. It also illustrates the use of a rapid electronic literature review as a clinical tool. The importance of updating records when a drug has been cleared of causing harm is highlighted.

48. Evaluating the Risk for Pregnancy-Associated Venous Thromboembolism: A 30-Year Study.

Author

Heit, J. A., Kobbervig, C. E., James, A. H., Petterson, T. M., Bailey, K. R., and Melton, III, L. J.

Subjects
THROMBOEMBOLISM, PREGNANT women, PULMONARY embolism, WOMEN'S health
Abstract

The article focuses on a study, which evaluates the risk for pregnancy-associated venous thromboembolism. 50,000 women who lived in Olmsted County, Minnesota, and who were pregnant during a 30-year period from 1966 to 1995 were included in the study. In general, risk for venous thromboembolism increased with each successive trimester of pregnancy but was highest in the postpartum period. In fact, the overall incidence of venous thromboembolism was 4 times higher in the postpartum period than it was during pregnancy, and the incidence of pulmonary embolism was 15 times higher.

Published
2005
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50. Is lipid lowering therapy an independent risk factor for venous thromboembolism? A population-based case-control study.

Author

Ashrani, A. A., Barsoum, M. K., Crusan, D. J., Petterson, T. M., Bailey, K. R., and Heit, J. A.

Subjects
*LIPID analysis, *PULMONARY embolism, *ANTILIPEMIC agents, *VENOUS thrombosis, *MYOCARDIAL infarction, THROMBOEMBOLISM treatment
Abstract

INTRODUCTION: The independent effect of lipid lowering therapy (LLT) on venous thromboembolism (VTE) risk is uncertain. OBJECTIVE: To test statin and non-statin LLT as potential VTE risk factors. METHODS: Using Rochester Epidemiology Project resources, we identified all Olmsted County, MN residents with objectively diagnosed incident VTE (cases) over the 13-year period, 1988-2000 (n=1340), and one to two matched controls (n=1538). We reviewed their complete medical records for baseline characteristics previously identified as independent VTE risk factors, and for statin and non-statin LLT. Using conditional logistic regression, we tested the overall effect of LLT on VTE risk and also separately explored the role of statin versus that of non-statin LLT, adjusting for other baseline characteristics. RESULTS: Among cases and controls, 74 and 111 received statin LLT, and 32 and 50 received non-statin LLT, respectively. Univariately, and after individually controlling for other potential VTE risk factors (i.e., BMI, trauma/fracture, leg paresis, hospitalization for surgery or medical illness, nursing home residence, active cancer, central venous catheter, varicose veins, prior superficial vein thrombosis, diabetes, congestive heart failure, angina/myocardial infarction, stroke, peripheral vascular disease, smoking, anticoagulation), LLT was associated with decreased odds of VTE (unadjusted OR=0.73; p=0.03). When considered separately, statin and non-statin LLT were each associated with moderate, non-significant lower odds of VTE. After adjusting for angina/myocardial infarction, each was significantly associated with decreased odds of VTE (OR=0.63, p<0.01 and OR=0.61, p=0.04, respectively). CONCLUSIONS: LLT is associated with decreased VTE risk after adjusting for known risk factors. [ABSTRACT FROM AUTHOR]

Published
2015
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