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982 results on '"Pette, D"'

1. Muscle Function at Altitude

Author

Cerretelli, P., Kayser, B., Hoppeler, H., Pette, D., Lahiri, Sukhamay, editor, Cherniack, Neil S., editor, and Fitzgerald, Robert S., editor

Published
1991
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3. Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8nr00603b

Author

Newland, B., Taplan, C., Pette, D., Friedrichs, J., Steinhart, M., Wang, W., Voit, B., Seib, F. P., and Werner, C.

Subjects
Nanotubes, Polymers, Breast Neoplasms, 3T3 Cells, Neoplasms, Experimental, Polyethylene Glycols, Chemistry, Drug Liberation, Mice, Drug Delivery Systems, Doxorubicin, Cell Line, Tumor, Animals, Humans
Abstract

Soft/flexible PEG-based polymer nanotubes released doxorubicin over a sustained period and reduced tumor growth in a metastatic breast cancer model., Nanotubes are emerging as promising materials for healthcare applications but the selection of clinically relevant starting materials for their synthesis remains largely unexplored. Here we present, for the first time, the synthesis of poly(ethylene glycol) (PEG) based nanotubes via the photopolymerization of poly(ethylene glycol) diacrylate and other diacrylate derivatives within the pores of anodized aluminum oxide templates. Template-assisted synthesis allowed the manufacture of a diverse set of polymeric nanotubes with tunable physical characteristics including diameter (∼200–400 nm) and stiffness (405–902 kPa). PEG nanotubes were subjected to cytotoxicty assessment in cell lines and primary stem cells and showed excellent cytocompatability (IC50 > 120 μg ml–1). Nanotubes were readily drug loaded but released the majority of the drug over 5 days. Direct administration of drug loaded nanotubes to human orthotopic breast tumors substantially reduced tumor growth and metastasis and outperformed i.v. administration at the equivalent dose. Overall, this nanotube templating platform is emerging as a facile route for the manufacture of poly(ethylene glycol) nanotubes.

Published
2018

9. Prolonged contraction-relaxation cycle of fast-twitch muscles in parvalbumin knockout mice

Author

Schwaller, B., Dick, J., Dhoot, G., Carroll, S., Vrbova, G., Nicotera, P., Pette, D., Wyss, A., Bluethmann, H., Hunziker, W., and Celio, M.R.

Subjects
Calcium-binding proteins -- Research, Muscle contraction -- Research, Muscles -- Physiological aspects, Mice -- Physiological aspects, Biological sciences
Abstract

Parvalbumin (PV)-deficient mice were created via homologous recombination to investigate the physiological role of the calcium-binding protein in fast-twitch muscles of mammals. Substantial differences in the PV -/- mice compared with wild-type animals were noted from isometric contraction in the tibialis anterior muscles and Ca2+ measurements in isolated fibers of fast-twitch muscles. A significant increase in both the half-relaxation and the rise time to the peak twitch tension was noted as well as, consequently, a higher twitch force than in heterozygous or wild-type animals.

Published
1999

20. Muscle Structure and Function after Exposure to High Altitude Hypoxia

Author

Howald, H., primary, Hoppeler, H., additional, Ciaassen, H., additional, Kayar, S., additional, Kleinert, E., additional, Schlegel, C., additional, Winterhaider, R., additional, Martinelli, M., additional, Pette, D., additional, Simoneau, J.-A., additional, Uber, A., additional, Cerretelli, P., additional, di Prampero, P.E., additional, and Ferretti, G., additional

Published
1990
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34. Cytoarchitectural and metabolic adaptations in muscles with mitochondrial and cytosolic creatine kinase deficiencies

Author

Steeghs, K., Oerlemans, F., de Haan, A., Heerschap, A., Verdoodt, L., de Bie, M., Ruitenbeek, W., Benders, A., Jost, C., Deursen, J., Tullson, P., Terjung, R., Jap, P., Jacob, W., Pette, D., Wieringa, B., and Kinesiology

Subjects
Adaptation and Cell Death [Cellular reprogramming in tissues of neuro-muscular origin as a response on genetic defects in the network for energy-homeostasis], Biomedische Magnetische Resonantie, adaptatie en celdood [Cellulaire herprogrammering in neuromusculaire weefsels in respons op genetische defecten in het cellulaire netwerk voor energie-homeostase], Biomedical Magnetic Resonance
Abstract

Item does not contain fulltext 12 p.

Published
1998

35. Altered Ca2+ Responses in Muscles with Combined Mitochondrial and Cytosolic Creatine Kinase Deficiencies

Author

Benders, A.A.G.M., Oerlemans, F.T.J.J., Haan, A.L.M. de, Heerschap, A., Ruitenbeek, W., Jost, C.R., Deursen, J.M.A. van, Perryman, B., Pette, D., Brückwilder, M.L.P., Koudijs, J.C.M., Jap, P.H.K., Veerkamp, J.H., and Wieringa, B.

Subjects
GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 24579___.PDF (Publisher’s version ) (Open Access)

Published
1997

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