244 results on '"Petruzzelli, M."'
Search Results
2. Free-amino acid metabolic profiling of visceral adipose tissue from obese subjects
- Author
-
Piro, M. C., Tesauro, M., Lena, A. M., Gentileschi, P., Sica, G., Rodia, G., Annicchiarico-Petruzzelli, M., Rovella, V., Cardillo, C., Melino, G., Candi, E., and Di Daniele, N.
- Published
- 2020
- Full Text
- View/download PDF
3. Demographic, clinical, and service-use characteristics related to the clinician’s recommendation to transition from child to adult mental health services
- Author
-
Gerritsen, S, van Bodegom, L, Dieleman, G, Overbeek, M, Verhulst, F, Wolke, D, Rizopoulos, D, Appleton, R, van Amelsvoort, T, Bodier Rethore, C, Bonnet-Brilhault, F, Charvin, I, Da Fonseca, D, Davidovic, N, Dodig-Curkovic, K, Ferrari, A, Fiori, F, Franic, T, Gatherer, C, de Girolamo, G, Heaney, N, Hendrickx, G, Jardri, R, Kolozsvari, A, Lida-Pulik, H, Lievesley, K, Madan, J, Mastroianni, M, Maurice, V, Mcnicholas, F, Nacinovich, R, Parenti, A, Paul, M, Purper-Ouakil, D, Rivolta, L, de Roeck, V, Russet, F, Saam, M, Sagar-Ouriaghli, I, Santosh, P, Sartor, A, Schulze, U, Scocco, P, Signorini, G, Singh, S, Singh, J, Speranza, M, Stagi, P, Stagni, P, Street, C, Tah, P, Tanase, E, Tremmery, S, Tuffrey, A, Tuomainen, H, Walker, L, Wilson, A, Maras, A, Adams, L, Allibrio, G, Armando, M, Aslan, S, Baccanelli, N, Balaudo, M, Bergamo, F, Bertani, A, Berriman, J, Boon, A, Braamse, K, Breuninger, U, Buttiglione, M, Buttle, S, Schandrin, A, Cammarano, M, Canaway, A, Cantini, F, Cappellari, C, Carenini, M, Carra, G, Ferrari, C, Chianura, K, Coleman, P, Colonna, A, Conese, P, Costanzo, R, Daffern, C, Danckaerts, M, de Giacomo, A, Ermans, J, Farmer, A, Fegert, J, Ferrari, S, Galea, G, Gatta, M, Gheza, E, Goglia, G, Grandetto, M, Griffin, J, Levi, F, Humbertclaude, V, Ingravallo, N, Invernizzi, R, Kelly, C, Killilea, M, Kirwan, J, Klockaerts, C, Kovac, V, Liew, A, Lippens, C, Macchi, F, Manenti, L, Margari, F, Margari, L, Martinelli, P, Mcfadden, L, Menghini, D, Miller, S, Monzani, E, Morini, G, Mutafov, T, O'Hara, L, Negrinotti, C, Nelis, E, Neri, F, Nikolova, P, Nossa, M, Cataldo, M, Noterdaeme, M, Operto, F, Panaro, V, Pastore, A, Pemmaraju, V, Pepermans, A, Petruzzelli, M, Presicci, A, Prigent, C, Rinaldi, F, Riva, E, Roekens, A, Rogers, B, Ronzini, P, Sakar, V, Salvetti, S, Martinelli, O, Sandhu, T, Schepker, R, Siviero, M, Slowik, M, Smyth, C, Conti, P, Spadone, M, Starace, F, Stoppa, P, Tansini, L, Toselli, C, Trabucchi, G, Tubito, M, van Dam, A, van Gutschoven, H, van West, D, Vanni, F, Vannicola, C, Varuzza, C, Varvara, P, Ventura, P, Vicari, S, Vicini, S, von Bentzel, C, Wells, P, Williams, B, Zabarella, M, Zamboni, A, Zanetti, E, Gerritsen S. E., van Bodegom L. S., Dieleman G. C., Overbeek M. M., Verhulst F. C., Wolke D., Rizopoulos D., Appleton R., van Amelsvoort T. A. M. J., Bodier Rethore C., Bonnet-Brilhault F., Charvin I., Da Fonseca D., Davidovic N., Dodig-Curkovic K., Ferrari A., Fiori F., Franic T., Gatherer C., de Girolamo G., Heaney N., Hendrickx G., Jardri R., Kolozsvari A., Lida-Pulik H., Lievesley K., Madan J., Mastroianni M., Maurice V., McNicholas F., Nacinovich R., Parenti A., Paul M., Purper-Ouakil D., Rivolta L., de Roeck V., Russet F., Saam M. C., Sagar-Ouriaghli I., Santosh P. J., Sartor A., Schulze U. M. E., Scocco P., Signorini G., Singh S. P., Singh J., Speranza M., Stagi P., Stagni P., Street C., Tah P., Tanase E., Tremmery S., Tuffrey A., Tuomainen H., Walker L., Wilson A., Maras A., Adams L., Allibrio G., Armando M., Aslan S., Baccanelli N., Balaudo M., Bergamo F., Bertani A., Berriman J., Boon A., Braamse K., Breuninger U., Buttiglione M., Buttle S., Schandrin A., Cammarano M., Canaway A., Cantini F., Cappellari C., Carenini M., Carra G., Ferrari C., Chianura K., Coleman P., Colonna A., Conese P., Costanzo R., Daffern C., Danckaerts M., de Giacomo A., Ermans J. -P., Farmer A., Fegert J. M., Ferrari S., Galea G., Gatta M., Gheza E., Goglia G., Grandetto M. R., Griffin J., Levi F. M., Humbertclaude V., Ingravallo N., Invernizzi R., Kelly C., Killilea M., Kirwan J., Klockaerts C., Kovac V., Liew A., Lippens C., Macchi F., Manenti L., Margari F., Margari L., Martinelli P., McFadden L., Menghini D., Miller S., Monzani E., Morini G., Mutafov T., O'Hara L., Negrinotti C., Nelis E., Neri F., Nikolova P., Nossa M., Cataldo M. G., Noterdaeme M., Operto F., Panaro V., Pastore A., Pemmaraju V., Pepermans A., Petruzzelli M. G., Presicci A., Prigent C., Rinaldi F., Riva E., Roekens A., Rogers B., Ronzini P., Sakar V., Salvetti S., Martinelli O., Sandhu T., Schepker R., Siviero M., Slowik M., Smyth C., Conti P., Spadone M. A., Starace F., Stoppa P., Tansini L., Toselli C., Trabucchi G., Tubito M., van Dam A., van Gutschoven H., van West D., Vanni F., Vannicola C., Varuzza C., Varvara P., Ventura P., Vicari S., Vicini S., von Bentzel C., Wells P., Williams B., Zabarella M., Zamboni A., Zanetti E., Gerritsen, S, van Bodegom, L, Dieleman, G, Overbeek, M, Verhulst, F, Wolke, D, Rizopoulos, D, Appleton, R, van Amelsvoort, T, Bodier Rethore, C, Bonnet-Brilhault, F, Charvin, I, Da Fonseca, D, Davidovic, N, Dodig-Curkovic, K, Ferrari, A, Fiori, F, Franic, T, Gatherer, C, de Girolamo, G, Heaney, N, Hendrickx, G, Jardri, R, Kolozsvari, A, Lida-Pulik, H, Lievesley, K, Madan, J, Mastroianni, M, Maurice, V, Mcnicholas, F, Nacinovich, R, Parenti, A, Paul, M, Purper-Ouakil, D, Rivolta, L, de Roeck, V, Russet, F, Saam, M, Sagar-Ouriaghli, I, Santosh, P, Sartor, A, Schulze, U, Scocco, P, Signorini, G, Singh, S, Singh, J, Speranza, M, Stagi, P, Stagni, P, Street, C, Tah, P, Tanase, E, Tremmery, S, Tuffrey, A, Tuomainen, H, Walker, L, Wilson, A, Maras, A, Adams, L, Allibrio, G, Armando, M, Aslan, S, Baccanelli, N, Balaudo, M, Bergamo, F, Bertani, A, Berriman, J, Boon, A, Braamse, K, Breuninger, U, Buttiglione, M, Buttle, S, Schandrin, A, Cammarano, M, Canaway, A, Cantini, F, Cappellari, C, Carenini, M, Carra, G, Ferrari, C, Chianura, K, Coleman, P, Colonna, A, Conese, P, Costanzo, R, Daffern, C, Danckaerts, M, de Giacomo, A, Ermans, J, Farmer, A, Fegert, J, Ferrari, S, Galea, G, Gatta, M, Gheza, E, Goglia, G, Grandetto, M, Griffin, J, Levi, F, Humbertclaude, V, Ingravallo, N, Invernizzi, R, Kelly, C, Killilea, M, Kirwan, J, Klockaerts, C, Kovac, V, Liew, A, Lippens, C, Macchi, F, Manenti, L, Margari, F, Margari, L, Martinelli, P, Mcfadden, L, Menghini, D, Miller, S, Monzani, E, Morini, G, Mutafov, T, O'Hara, L, Negrinotti, C, Nelis, E, Neri, F, Nikolova, P, Nossa, M, Cataldo, M, Noterdaeme, M, Operto, F, Panaro, V, Pastore, A, Pemmaraju, V, Pepermans, A, Petruzzelli, M, Presicci, A, Prigent, C, Rinaldi, F, Riva, E, Roekens, A, Rogers, B, Ronzini, P, Sakar, V, Salvetti, S, Martinelli, O, Sandhu, T, Schepker, R, Siviero, M, Slowik, M, Smyth, C, Conti, P, Spadone, M, Starace, F, Stoppa, P, Tansini, L, Toselli, C, Trabucchi, G, Tubito, M, van Dam, A, van Gutschoven, H, van West, D, Vanni, F, Vannicola, C, Varuzza, C, Varvara, P, Ventura, P, Vicari, S, Vicini, S, von Bentzel, C, Wells, P, Williams, B, Zabarella, M, Zamboni, A, Zanetti, E, Gerritsen S. E., van Bodegom L. S., Dieleman G. C., Overbeek M. M., Verhulst F. C., Wolke D., Rizopoulos D., Appleton R., van Amelsvoort T. A. M. J., Bodier Rethore C., Bonnet-Brilhault F., Charvin I., Da Fonseca D., Davidovic N., Dodig-Curkovic K., Ferrari A., Fiori F., Franic T., Gatherer C., de Girolamo G., Heaney N., Hendrickx G., Jardri R., Kolozsvari A., Lida-Pulik H., Lievesley K., Madan J., Mastroianni M., Maurice V., McNicholas F., Nacinovich R., Parenti A., Paul M., Purper-Ouakil D., Rivolta L., de Roeck V., Russet F., Saam M. C., Sagar-Ouriaghli I., Santosh P. J., Sartor A., Schulze U. M. E., Scocco P., Signorini G., Singh S. P., Singh J., Speranza M., Stagi P., Stagni P., Street C., Tah P., Tanase E., Tremmery S., Tuffrey A., Tuomainen H., Walker L., Wilson A., Maras A., Adams L., Allibrio G., Armando M., Aslan S., Baccanelli N., Balaudo M., Bergamo F., Bertani A., Berriman J., Boon A., Braamse K., Breuninger U., Buttiglione M., Buttle S., Schandrin A., Cammarano M., Canaway A., Cantini F., Cappellari C., Carenini M., Carra G., Ferrari C., Chianura K., Coleman P., Colonna A., Conese P., Costanzo R., Daffern C., Danckaerts M., de Giacomo A., Ermans J. -P., Farmer A., Fegert J. M., Ferrari S., Galea G., Gatta M., Gheza E., Goglia G., Grandetto M. R., Griffin J., Levi F. M., Humbertclaude V., Ingravallo N., Invernizzi R., Kelly C., Killilea M., Kirwan J., Klockaerts C., Kovac V., Liew A., Lippens C., Macchi F., Manenti L., Margari F., Margari L., Martinelli P., McFadden L., Menghini D., Miller S., Monzani E., Morini G., Mutafov T., O'Hara L., Negrinotti C., Nelis E., Neri F., Nikolova P., Nossa M., Cataldo M. G., Noterdaeme M., Operto F., Panaro V., Pastore A., Pemmaraju V., Pepermans A., Petruzzelli M. G., Presicci A., Prigent C., Rinaldi F., Riva E., Roekens A., Rogers B., Ronzini P., Sakar V., Salvetti S., Martinelli O., Sandhu T., Schepker R., Siviero M., Slowik M., Smyth C., Conti P., Spadone M. A., Starace F., Stoppa P., Tansini L., Toselli C., Trabucchi G., Tubito M., van Dam A., van Gutschoven H., van West D., Vanni F., Vannicola C., Varuzza C., Varvara P., Ventura P., Vicari S., Vicini S., von Bentzel C., Wells P., Williams B., Zabarella M., Zamboni A., and Zanetti E.
- Abstract
Purpose: The service configuration with distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) may be a barrier to continuity of care. Because of a lack of transition policy, CAMHS clinicians have to decide whether and when a young person should transition to AMHS. This study describes which characteristics are associated with the clinicians’ advice to continue treatment at AMHS. Methods: Demographic, family, clinical, treatment, and service-use characteristics of the MILESTONE cohort of 763 young people from 39 CAMHS in Europe were assessed using multi-informant and standardized assessment tools. Logistic mixed models were fitted to assess the relationship between these characteristics and clinicians’ transition recommendations. Results: Young people with higher clinician-rated severity of psychopathology scores, with self- and parent-reported need for ongoing treatment, with lower everyday functional skills and without self-reported psychotic experiences were more likely to be recommended to continue treatment. Among those who had been recommended to continue treatment, young people who used psychotropic medication, who had been in CAMHS for more than a year, and for whom appropriate AMHS were available were more likely to be recommended to continue treatment at AMHS. Young people whose parents indicated a need for ongoing treatment were more likely to be recommended to stay in CAMHS. Conclusion: Although the decision regarding continuity of treatment was mostly determined by a small set of clinical characteristics, the recommendation to continue treatment at AMHS was mostly affected by service-use related characteristics, such as the availability of appropriate services.
- Published
- 2022
4. 187 Extracellular serine requirement identifies a therapeutic target for psoriasis
- Author
-
Cappello, A., primary, Madonna, S., additional, Rinaldo, S., additional, Paone, A., additional, Scarponi, C., additional, Belardo, A., additional, Zolla, L., additional, Pallotta, S., additional, Annicchiarico-Petruzzelli, M., additional, Albanesi, C., additional, Cutruzzolà, F., additional, Melino, G., additional, and Candi, E., additional
- Published
- 2022
- Full Text
- View/download PDF
5. ΔNp63 targets cytoglobin to inhibit oxidative stress-induced apoptosis in keratinocytes and lung cancer
- Author
-
Latina, A, Viticchiè, G, Lena, A M, Piro, M C, Annicchiarico-Petruzzelli, M, Melino, G, and Candi, E
- Published
- 2016
- Full Text
- View/download PDF
6. p63 controls cell migration and invasion by transcriptional regulation of MTSS1
- Author
-
Giacobbe, A, Compagnone, M, Bongiorno-Borbone, L, Antonov, A, Markert, E K, Zhou, J H, Annicchiarico-Petruzzelli, M, Melino, G, and Peschiaroli, A
- Published
- 2016
- Full Text
- View/download PDF
7. Early neutrophilia marked by aerobic glycolysis sustains host 3 metabolism and delays cancer cachexia
- Author
-
Petruzzelli, M, Ferrer, M, Schuijs, MJ, Kleeman, SO, Mourikis, N, Hall, Z, Perera, D, Raghunathan, S, Vacca, M, Gaude, E, Lukey, MJ, Jodrell, DI, Frezza, C, Wagner, EF, Venkitaraman, AR, Halim, TYF, and Janowitz, T
- Subjects
host ,neutrophils ,cancer ,1112 Oncology and Carcinogenesis ,aerobic glycolysis ,cachexia ,metabolism - Abstract
An elevated neutrophil–lymphocyte ratio negatively predicts the outcome of patients with cancer and is associated with cachexia, the terminal wasting syndrome. Here, using murine model systems of colorectal and pancreatic cancer we show that neutrophilia in the circulation and multiple organs, accompanied by extramedullary hematopoiesis, is an early event during cancer progression. Transcriptomic and metabolic assessment reveals that neutrophils in tumor-bearing animals utilize aerobic glycolysis, similar to cancer cells. Although pharmacological inhibition of aerobic glycolysis slows down tumor growth in C26 tumor-bearing mice, it precipitates cachexia, thereby shortening the overall survival. This negative effect may be explained by our observation that acute depletion of neutrophils in pre-cachectic mice impairs systemic glucose homeostasis secondary to altered hepatic lipid processing. Thus, changes in neutrophil number, distribution, and metabolism play an adaptive role in host metabolic homeostasis during cancer progression. Our findings provide insight into early events during cancer progression to cachexia, with implications for therapy.
- Published
- 2022
8. Carotid artery stenting during endovascular thrombectomy for acute ischemic stroke with tandem occlusion: the Italian Registry of Endovascular Treatment in Acute Stroke
- Author
-
Sallustio, Fabrizio, Pracucci, Giovanni, Cappellari, Manuel, Saia, Valentina, Mascolo, Alfredo Paolo, Marrama, Federico, Gandini, Roberto, Koch, Giacomo, Diomedi, Marina, D’Agostino, Federica, Rocco, Alessandro, Da Ros, Valerio, Wlderk, Andrea, Nezzo, Marco, Argirò, Renato, Morosetti, Daniele, Renieri, Leonardo, Nencini, Patrizia, Vallone, Stefano, Zini, Andrea, Bigliardi, Guido, Pitrone, Antonio, Grillo, Francesco, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Naldi, Andrea, Carità, Giuseppe, Casetta, Ilaria, Gasparotti, Roberto, Magoni, Mauro, Simonetti, Luigi, Haznedari, Nicolò, Paolucci, Matteo, Mavilio, Nicola, Malfatto, Laura, Menozzi, Roberto, Genovese, Antonio, Cosottini, Mirco, Orlandi, Giovanni, Comai, Alessio, Franchini, Enrica, Pedicelli, Alessandro, Frisullo, Giovanni, Puglielli, Edoardo, Casalena, Alfonsina, Cester, Giacomo, Baracchini, Claudio, Castellano, Davide, Di Liberto, Alessandra, Ricciardi, Giuseppe Kenneth, Chiumarulo, Luigi, Petruzzellis, Marco, Lafe, Elvis, Persico, Alessandra, Cavasin, Nicola, Critelli, Adriana, Semeraro, Vittorio, Tinelli, Angelica, Giorgianni, Andrea, Carimati, Federico, Auteri, William, Rizzuto, Stefano, Biraschi, Francesco, Nicolini, Ettore, Ferrari, Antonio, Melis, Maurizio, Calia, Stefano, Tassinari, Tiziana, Nuzzi, Nunzio Paolo, Corato, Manuel, Sacco, Simona, Squassina, Guido, Invernizzi, Paolo, Gallesio, Ivan, Ruiz, Luigi, Dui, Giovanni, Carboni, Nicola, Amistà, Pietro, Russo, Monia, Maiore, Mario, Zanda, Bastianina, Craparo, Giuseppe, Mannino, Marina, Inzitari, Domenico, Toni, Danilo, Mangiafico, Salvatore, Gasparotti, R., Inzitari, D., Mangiafico, S., Toni, D., Vallone, S., Zini, A., Bergui, M., Causin, F., Ciccone, A., Nencini, P., Saletti, A., Sallustio, F., Tassi, R., Thyrion, F. Zappoli, Pracucci, G., Saia, V., Gandini, R., Da Ros, V., Greco, L., Morosetti, D., Diomedi, M., Nappini, S., Limbucci, N., Renieri, L., Fainardi, E., Verganti, L., Sacchetti, F., Zelent, G., Bigliardi, G., Dell’Acqua, M. L., Picchetto, L., Vandelli, L., Pentore, R., Maffei, S., Nichelli, P., Longo, M., Pitrone, A., Vinci, S. L., Velo, M., Caragliano, A., Tessitore, A., Bonomo, O., Musolino, R., La Spina, P., Casella, C., Fazio, M. C., Grillo, F., Cotroneo, M., Dell’Aera, C., Francalanza, I., Bracco, S., Cioni, S., Gennari, P., Vallone, I. M., Cerase, A., Martini, G., Stura, G., Daniele, D., Cerrato, P., Naldi, A., Onofrio, M., De Vito, A., Azzini, C., Casetta, I., Mardighian, D., Frigerio, M., Magoni, M., Costa, A., Simonetti, L., Cirillo, L., Taglialatela, F., Isceri, S., Princiotta, C., Dall’Olio, M., Cellerini, M., Gentile, M., Piccolo, L., Migliaccio, L., Brancaleoni, L., Naldi, F., Romoli, M., Zaniboni, A., Ruggiero, M., Sanna, A., Haznedari, N., Commodaro, C., Longoni, M., Biguzzi, S., Cordici, F., Malatesta, E., Castellan, L., Mavilio, N., Salsano, G., Malfatto, L., Finocchi, C., Menozzi, R., Piazza, P., Epifani, E., Andreone, A., Scoditti, U., Castellini, P., Latte, L., Grisendi, I., Cosottini, M., Puglioli, M., Lazzarotti, G., Lauretti, D., Mancuso, M., Giannini, N., Maccarone, M., Orlandi, G., Comai, A., Bonatti, G., Nano, G., Ferro, F., Bonatti, M., Dall’Ora, E., Dossi, R. Currò, Turri, E., Turri, M., Colosimo, C., Pedicelli, A., D’Argento, F., Alexandre, A., Frisullo, G., Di Egidio, V., Puglielli, E. G., Ruggero, L., Assetta, M., Casalena, A., Cester, G., Baracchini, C., Viaro, F., Pieroni, A., Vaudano, G., Comelli, C., Di Maggio, L., Castellano, D., Cavallo, R., Duc, E., Chianale, G., Ciceri, E. F. M., Plebani, M., Augelli, R., Zampieri, P., Grazioli, A., Cappellari, M., Forlivesi, S., Tomelleri, G., Micheletti, N., Chiumarulo, L., Zimatore, D. S., Federico, F., Petruzzelli, M., Zappoli, F., Lafe, E., Sanfilippo, G., Sgreccia, A., Martignoni, A., Cavallini, A., Denaro, F., Persico, A., Cagliari, E., Cavasin, N., Quatrale, R., Critelli, A., Burdi, N., Semeraro, V., Lucarelli, N., Ganimede, M. P., Internò, S., Tinelli, A., Prontera, M. P., Pesare, A., Cotroneo, E., Pampana, E., Ricciardi, F., Gigli, R., Pezzella, F. R., Corsi, F., Giorgianni, A., Baruzzi, F., Pellegrino, C., Terrana, A., Versino, M., Delodovici, M. L., Carimati, F., Cariddi, L. Princiotta, Auteri, W., Di Benedetto, O., Silvagni, U., Perrotta, P., Crispino, E., Petrone, A., Stancati, F., Rizzuto, S., Pugliese, P., Pisani, E., Siniscalchi, A., Gaudiano, C., Pirritano, D., Del Giudice, F., Piano, M., Agostoni, E., Motto, C., Gatti, A., Guccione, A., Tortorella, R., Stecco, A., Guzzardi, G., Del Sette, B., Coppo, L., Baldan, J., Romano, D., Siani, A., Locatelli, G., Saponiero, R., Napolitano, R., De Gregorio, M., Volpe, G., Tenuta, M., Guidetti, G., Biraschi, F., Wulbek, A., Falcou, A., Anzini, A., Mancini, A., De Michele, M., Fausti, S., Di Mascio, M. T., Durastanti, L., Sbardella, E., Mellina, V., Nicolini, E., Comelli, S., Ganau, C., Corraine, S., Fusaro, F., Ferrari, A., Schirru, F., Ledda, V., Secci, S., Melis, M., Piras, V., Moller, J., Padolecchia, R., Allegretti, L., Caldiera, V., Calia, S., Ganci, G., Tassinari, T., Sugo, A., De Nicola, M., Giannoni, M., Bruni, S., Gambelli, E., Provinciali, L., Nuzzi, N. P., Marcheselli, S., Corato, M., Scomazzoni, F., Simionato, F., Roveri, L., Filauri, P., Sacco, S., Orlandi, B., De Santis, F., Tiseo, C., Notturno, F., Ornello, R., Pavia, M., Squassina, G., Cobelli, M., Morassi, M., Magni, E., Invernizzi, P., Pepe, F., Bigni, B., Costa, P., Crabbio, M., Griffini, S., Palmerini, F., Piras, M. P., Gallesio, I., Barbero, S., Ferrandi, D., Dui, G., Fancello, M. C., Zedda, S., Ticca, A., Saddi, M. V., Deiana, G., Rossi, R., Carboni, N., Mela, A., Amistà, P., Russo, M., Iannucci, G., Pinna, V., Di Clemente, L., Santi, M., De Boni, A., De Luca, C., Natrella, M., Fanelli, G., Cristoferi, M., Bottacchi, E., Corso, G., Tosi, P., Sessa, M., Giossi, A., Baietti, Null, Romano, G., Meineri, P., Armentano, A., Versace, P., Arcudi, L., Galvano, G., Petralia, B., Feraco, P., Luppi, G., Giometto, B., Bignamini, V., Piffer, S., Meloni, G. B., Fabio, C., Maiore, M., Pintus, F., Pischedda, A., Manca, A., Mongili, C., Zanda, B., Baule, A., Florio, F., Ciccarese, G., Leone, M., Di Viesti, P., Pappalardo, M. P., Craparo, G., Gallo, C., Monaco, S., Mannino, M., Muto, M., Guarnieri, Gl., Andreone, V., Passalacqua, G., Allegritti, M., Caproni, S., Filizzolo, M., Salmaggi, A., Giordano, A., Marini, C., Frattale, I., Lucente, G., Nozzoli, C., and Lupo, F. A.
- Subjects
Stent ,Acute stroke ,Settore MED/37 - Neuroradiologia ,Acute stroke Internal carotid artery diseases Stent Thrombectomy ,Neurology (clinical) ,General Medicine ,Settore MED/26 ,Internal carotid artery diseases ,Thrombectomy - Abstract
The management of tandem extracranial internal carotid artery and intracranial large vessel occlusion during endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) has been under-investigated. We sought to investigate outcomes of AIS patients with tandem occlusion (TO) treated with carotid artery stenting (CAS) compared to those not treated with CAS (no-CAS) during EVT.We performed a cohort study using data from AIS patients enrolled in the Italian Registry of Endovascular Treatment in Acute Stroke. Outcomes were 3 months' mortality, functional outcome, complete and successful recanalization, any intracranial hemorrhage, parenchymal hematoma and symptomatic intracerebral hemorrhage.Among 466 AIS patients with TO, CAS patients were 122 and no-CAS patients were 226 (118 excluded). After adjustment for unbalanced variables, CAS was associated with a lower rate of 3 months' mortality (OR 0.407, 95% CI 0.171-0.969, p = 0.042). After adjustment for pre-defined variables, CAS was associated with a lower rate of 3 months' mortality (aOR 0.430, 95% CI 0.187-0.989, p = 0.047) and a higher rate of complete recanalization (aOR 1.986, 95% CI 1.121-3.518, p = 0.019), successful recanalization (aOR 2.433, 95% CI 1.263-4.686, p = 0.008) and parenchymal hematoma (aOR 2.876, 95% CI 1.173-7.050, p = 0.021). CAS was associated with lower 3 months mortality (OR 0.373, 95% CI 0.141-0.982, p = 0.046) and higher rates of successful recanalization (OR 2.082, 95% CI 1.099-3.942, p = 0.024) after adjustment for variables associated with 3 months' mortality and successful recanalization, respectively.Among AIS patients with TO, CAS during EVT was associated with a higher rate of successful reperfusion and a lower rate of 3 months' mortality.
- Published
- 2022
9. Cutaneous mosaicism, in KRT1 pI479T patient, caused by the somatic loss of the wild-type allele, leads to the increase in local severity of the disease
- Author
-
Palombo, R., Giannella, E., Didona, B., Annicchiarico-Petruzzelli, M., Melino, G., and Terrinoni, A.
- Published
- 2016
- Full Text
- View/download PDF
10. 1313MO Safety and preliminary efficacy of AZD7789, a bispecific antibody targeting PD-1 and TIM-3, in patients (pts) with stage IIIB–IV non-small-cell lung cancer (NSCLC) with previous anti-PD-(L)1 therapy
- Author
-
Besse, B., Italiano, A., Cousin, S., Ruiter, G., Felip, E., Castanon Alvarez, E., Ramalingam, S.S., Rolfo, C.D., Spigel, D.R., Andrew, D., Cho, S., Collins, T., Hansen, A., Hawkins, G., Kurek, R., Ceaicovscaia, N., Petruzzelli, M., Dean, E.J., and Sacher, A.
- Published
- 2023
- Full Text
- View/download PDF
11. Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2
- Author
-
Modica, S., Morgano, A., Salvatore, L., Petruzzelli, M., Vanier, M.-T., Valanzano, R., Esposito, D.L., Palasciano, G., Duluc, I., Freund, J.-N., Mariani-Costantini, R., and Moschetta, A.
- Subjects
Colorectal cancer -- Development and progression ,Colorectal cancer -- Research ,Transcription factors -- Physiological aspects ,Transcription factors -- Research ,Insulin -- Receptors ,Insulin -- Physiological aspects ,Insulin -- Research ,Health - Published
- 2009
12. Indomethacin Enhances Bile Salt Detergent Activity: Relevance for NSAIDs-Induced Gastrointestinal Mucosal Injury
- Author
-
Petruzzelli, M., Moschetta, A., Renooij, W., De Smet, M. B. M., Palasciano, G., Portincasa, P., and Van Erpecum, K. J.
- Published
- 2006
- Full Text
- View/download PDF
13. Symptoms and diagnosis of gallbladder stones
- Author
-
Portincasa, P., Moschetta, A., Petruzzelli, M., Palasciano, G., Di Ciaula, A., and Pezzolla, A.
- Published
- 2006
- Full Text
- View/download PDF
14. 1940P CALIBRATION: Can early changes in circulating tumour DNA (ctDNA) predict durable tumour responses in patients (pts) with advanced esophageal adenocarcinoma (EAC) receiving anti PD-L1 antibody durvalumab (D)?
- Author
-
Linossi, C., primary, Funingana, I.G., additional, Petruzzelli, M., additional, Rala de Paula, B.H., additional, O'Donovan, M., additional, Andrea, M., additional, Hewitt, S., additional, Williams, A.L., additional, Grehan, N., additional, Redmond, A., additional, Smyth, E.C., additional, Baird, R.D., additional, Godfrey, E.M., additional, Di Pietro, M., additional, Faull, I., additional, Dovedi, S., additional, Fitzgerald, R.C., additional, and Pacey, S., additional
- Published
- 2020
- Full Text
- View/download PDF
15. Biliary phospholipids sustain intestinal mucosa regeneration and tumorigenesis: 301
- Author
-
Petruzzelli, M., Murzilli, S., Salvatore, L., DʼOrazio, A., DʼErrico, I., Portincasa, P., Palasciano, G., van Erpecum, K. J., and Moschetta, A.
- Published
- 2010
16. Micellar lipid composition profoundly affects LXR-dependent cholesterol transport across CaCo2 cells: 204
- Author
-
Petruzzelli, M., Groen, A. K., van Erpecum, K. J., Vrins, C., van der Velde, A. E., Portincasa, P., Palasciano, G., van Berge Henegouwen, G. P., Lo Sasso, G., Morgano, A., and Moschetta, A.
- Published
- 2010
17. Hepatic transcriptional resistance induced by obesity in complementary murine models: 8
- Author
-
Petruzzelli, M., Murzilli, S., Salvatore, L., Portincasa, P., Palasciano, G., and Moschetta, A.
- Published
- 2009
18. Fibroblast growth and polymorphonuclear granulocyte activation in the presence of a new biologically active sol–gel glass
- Author
-
PALUMBO, G, AVIGLIANO, L, STRUKUL, G, PINNA, F, PRINCIPE, D. DEL, D’ANGELO, I, ANNICCHIARICO-PETRUZZELLI, M, LOCARDI, B, and ROSATO, N
- Published
- 1997
- Full Text
- View/download PDF
19. Taurodeoxycholate causes redox changes in colonic mucosa: 15
- Author
-
Portincasa, P., Grattagliano, I., Gargano, I., Vacca, M., Petruzzelli, M., Moschetta, A., Calamita, G., and Palasciano, G.
- Published
- 2007
20. Indomethacin disrupts the protective effect of phosphatidylcholine against bile salt-induced ileal mucosa injury
- Author
-
Venneman, N. G., Petruzzelli, M., van Dijk, J. E., Verheem, A., Akkermans, L. M. A., Kroese, A. B. A., and van Erpecum, K. J.
- Published
- 2006
21. Reactive oxygen intermediates in autoimmune islet cell destruction of the NOD mouse induced by peritoneal exudate cells (rich in macrophages) but not T cells
- Author
-
Horio, F., Fukuda, M., Katoh, H., Petruzzelli, M., Yano, N., Rittershaus, C., Bonner-Weir, S., and Hattori, M.
- Published
- 1994
- Full Text
- View/download PDF
22. Characterisation of a human glioblastoma cell line (LI) expressing hypothalamic and pituitary hormones
- Author
-
Savarese, A., Annicchiarico-Petruzzelli, M., Citro, G., Zupi, G., Spagnoli, L. G., Colantoni, A., Vernole, P., Stephanou, A., Knight, R. A., Guerrieri, P., and Melino, G.
- Published
- 1992
- Full Text
- View/download PDF
23. Increased micellar phospholipids are needed to prevent bile salt (BS)-detergent activity in presence of bilirubin (BI): relevance in cholestasis
- Author
-
Portincasa, P., Moschetta, A., Petruzzelli, M., Vacca, M., Krawczyk, M., and Palasciano, G.
- Published
- 2004
24. Time-dependent changes in bile secretion and composition after orthotopic liver transplantation (OLT): a simple tool to predict a positive outcome
- Author
-
Portincasa, P., Moschetta, A., Lupo, G., Rotelli, M. T., Petruzzelli, M., De Venuto, R., Panebianco, A., Panzera, P. C., Carbotta, G., Grattagliano, I., Memeo, V., and Palasciano, G.
- Published
- 2004
25. The use of aerial and close-range photogrammetry to study dinosaur tracksites both at the meso- and macro-scale: the cases of the Lavini di Marco (Lower Jurassic, Hettangian - Trentino Alto-Adige) and Molfetta (Lower Cretaceous, Aptian-Albian - Apulia) tracksites
- Author
-
Petti, F. M., Petruzzelli, M., Conti, J., Spalluto, L., Wagensommer, A., Bernardi, M., Tomasoni, R., Antonelli, M., Sacco, E., Pignatti, J., Sabato, L., and Tropeano, M.
- Subjects
dinosaurs ,tracksites ,Jurassic ,Cretaceous ,Italy - Published
- 2018
26. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- Author
-
Galluzzi, L, Vitale, I, Aaronson, SA, Abrams, JM, Adam, D, Agostinis, P, Alnemri, ES, Altucci, L, Amelio, I, Andrews, DW, Annicchiarico-Petruzzelli, M, Antonov, AV, Arama, E, Baehrecke, EH, Barlev, NA, Bazan, NG, Bernassola, F, Bertrand, MJM, Bianchi, K, Blagosklonny, MV, Blomgren, K, Borner, C, Boya, P, Brenner, C, Campanella, M, Candi, E, Carmona-Gutierrez, D, Cecconi, F, Chan, FK-M, Chandel, NS, Cheng, EH, Chipuk, JE, Cidlowski, JA, Ciechanover, A, Cohen, GM, Conrad, M, Cubillos-Ruiz, JR, Czabotar, PE, D'Angiolella, V, Dawson, TM, Dawson, VL, De laurenzi, V, De Maria, R, Debatin, K-M, DeBerardinis, RJ, Deshmukh, M, Di Daniele, N, Di Virgilio, F, Dixit, VM, Dixon, SJ, Duckett, CS, Dynlacht, BD, El-Deiry, WS, Elrod, JW, Fimia, GM, Fulda, S, Garcia-Saez, AJ, Garg, AD, Garrido, C, Gavathiotis, E, Golstein, P, Gottlieb, E, Green, DR, Greene, LA, Gronemeyer, H, Gross, A, Hajnoczky, G, Hardwick, JM, Harris, IS, Hengartner, MO, Hetz, C, Ichijo, H, Jaattela, M, Joseph, B, Jost, PJ, Juin, PP, Kaiser, WJ, Karin, M, Kaufmann, T, Kepp, O, Kimchi, A, Kitsis, RN, Klionsky, DJ, Knight, RA, Kumar, S, Lee, SW, Lemasters, JJ, Levine, B, Linkermann, A, Lipton, SA, Lockshin, RA, Lopez-Otin, C, Lowe, SW, Luedde, T, Lugli, E, MacFarlane, M, Madeo, F, Malewicz, M, Malorni, W, Manic, G, Marine, J-C, Martin, SJ, Martinou, J-C, Medema, JP, Mehlen, P, Meier, P, Melino, S, Miao, EA, Molkentin, JD, Moll, UM, Munoz-Pinedo, C, Nagata, S, Nunez, G, Oberst, A, Oren, M, Overholtzer, M, Pagano, M, Panaretakis, T, Pasparakis, M, Penninger, JM, Pereira, DM, Pervaiz, S, Peter, ME, Piacentini, M, Pinton, P, Prehn, JHM, Puthalakath, H, Rabinovich, GA, Rehm, M, Rizzuto, R, Rodrigues, CMP, Rubinsztein, DC, Rudel, T, Ryan, KM, Sayan, E, Scorrano, L, Shao, F, Shi, Y, Silke, J, Simon, H-U, Sistigu, A, Stockwell, BR, Strasser, A, Szabadkai, G, Tait, SWG, Tang, D, Tavernarakis, N, Thorburn, A, Tsujimoto, Y, Turk, B, Vanden Berghe, T, Vandenabeele, P, Heiden, MGV, Villunger, A, Virgin, HW, Vousden, KH, Vucic, D, Wagner, EF, Walczak, H, Wallach, D, Wang, Y, Wells, JA, Wood, W, Yuan, J, Zakeri, Z, Zhivotovsky, B, Zitvogel, L, Melino, G, Kroemer, G, Galluzzi, L, Vitale, I, Aaronson, SA, Abrams, JM, Adam, D, Agostinis, P, Alnemri, ES, Altucci, L, Amelio, I, Andrews, DW, Annicchiarico-Petruzzelli, M, Antonov, AV, Arama, E, Baehrecke, EH, Barlev, NA, Bazan, NG, Bernassola, F, Bertrand, MJM, Bianchi, K, Blagosklonny, MV, Blomgren, K, Borner, C, Boya, P, Brenner, C, Campanella, M, Candi, E, Carmona-Gutierrez, D, Cecconi, F, Chan, FK-M, Chandel, NS, Cheng, EH, Chipuk, JE, Cidlowski, JA, Ciechanover, A, Cohen, GM, Conrad, M, Cubillos-Ruiz, JR, Czabotar, PE, D'Angiolella, V, Dawson, TM, Dawson, VL, De laurenzi, V, De Maria, R, Debatin, K-M, DeBerardinis, RJ, Deshmukh, M, Di Daniele, N, Di Virgilio, F, Dixit, VM, Dixon, SJ, Duckett, CS, Dynlacht, BD, El-Deiry, WS, Elrod, JW, Fimia, GM, Fulda, S, Garcia-Saez, AJ, Garg, AD, Garrido, C, Gavathiotis, E, Golstein, P, Gottlieb, E, Green, DR, Greene, LA, Gronemeyer, H, Gross, A, Hajnoczky, G, Hardwick, JM, Harris, IS, Hengartner, MO, Hetz, C, Ichijo, H, Jaattela, M, Joseph, B, Jost, PJ, Juin, PP, Kaiser, WJ, Karin, M, Kaufmann, T, Kepp, O, Kimchi, A, Kitsis, RN, Klionsky, DJ, Knight, RA, Kumar, S, Lee, SW, Lemasters, JJ, Levine, B, Linkermann, A, Lipton, SA, Lockshin, RA, Lopez-Otin, C, Lowe, SW, Luedde, T, Lugli, E, MacFarlane, M, Madeo, F, Malewicz, M, Malorni, W, Manic, G, Marine, J-C, Martin, SJ, Martinou, J-C, Medema, JP, Mehlen, P, Meier, P, Melino, S, Miao, EA, Molkentin, JD, Moll, UM, Munoz-Pinedo, C, Nagata, S, Nunez, G, Oberst, A, Oren, M, Overholtzer, M, Pagano, M, Panaretakis, T, Pasparakis, M, Penninger, JM, Pereira, DM, Pervaiz, S, Peter, ME, Piacentini, M, Pinton, P, Prehn, JHM, Puthalakath, H, Rabinovich, GA, Rehm, M, Rizzuto, R, Rodrigues, CMP, Rubinsztein, DC, Rudel, T, Ryan, KM, Sayan, E, Scorrano, L, Shao, F, Shi, Y, Silke, J, Simon, H-U, Sistigu, A, Stockwell, BR, Strasser, A, Szabadkai, G, Tait, SWG, Tang, D, Tavernarakis, N, Thorburn, A, Tsujimoto, Y, Turk, B, Vanden Berghe, T, Vandenabeele, P, Heiden, MGV, Villunger, A, Virgin, HW, Vousden, KH, Vucic, D, Wagner, EF, Walczak, H, Wallach, D, Wang, Y, Wells, JA, Wood, W, Yuan, J, Zakeri, Z, Zhivotovsky, B, Zitvogel, L, Melino, G, and Kroemer, G
- Abstract
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.
- Published
- 2018
27. Arterial ageing: from endothelial dysfunction to vascular calcification
- Author
-
Tesauro, M, Mauriello, A, Rovella, V, Annicchiarico-Petruzzelli, M, Cardillo, Carmine, Melino, G, Di Daniele, N, Cardillo C (ORCID:0000-0001-5182-3005), Tesauro, M, Mauriello, A, Rovella, V, Annicchiarico-Petruzzelli, M, Cardillo, Carmine, Melino, G, Di Daniele, N, and Cardillo C (ORCID:0000-0001-5182-3005)
- Abstract
Complex structural and functional changes occur in the arterial system with advancing age. The aged artery is characterized by changes in microRNA expression patterns, autophagy, smooth muscle cell migration and proliferation, and arterial calcification with progressively increased mechanical vessel rigidity and stiffness. With age the vascular smooth muscle cells modify their phenotype from contractile to 'synthetic' determining the development of intimal thickening as early as the second decade of life as an adaptive response to forces acting on the arterial wall. The increased permeability observed in intimal thickening could represent the substrate on which low-level atherosclerotic stimuli can promote the development of advanced atherosclerotic lesions. In elderly patients the atherosclerotic plaques tend to be larger with increased vascular stenosis. In these plaques there is a progressive accumulation of both lipids and collagen and a decrease of inflammation. Similarly the plaques from elderly patients show more calcification as compared with those from younger patients. The coronary artery calcium score is a well-established marker of adverse cardiovascular outcomes. The presence of diffuse calcification in a severely stenotic segment probably induces changes in mechanical properties and shear stress of the arterial wall favouring the rupture of a vulnerable lesion in a less stenotic adjacent segment. Oxidative stress and inflammation appear to be the two primary pathological mechanisms of ageing-related endothelial dysfunction even in the absence of clinical disease. Arterial ageing is no longer considered an inexorable process. Only a better understanding of the link between ageing and vascular dysfunction can lead to significant advances in both preventative and therapeutic treatments with the aim that in the future vascular ageing may be halted or even reversed.
- Published
- 2017
28. Arterial ageing: from endothelial dysfunction to vascular calcification.
- Author
-
Tesauro, M., Mauriello, A., Rovella, V., Annicchiarico‐Petruzzelli, M., Cardillo, C., Melino, G., Di Daniele, N., and Annicchiarico-Petruzzelli, M
- Subjects
CALCIFICATION ,ENDOTHELIUM diseases ,RNA ,VASCULAR smooth muscle ,ATHEROSCLEROSIS - Abstract
Complex structural and functional changes occur in the arterial system with advancing age. The aged artery is characterized by changes in microRNA expression patterns, autophagy, smooth muscle cell migration and proliferation, and arterial calcification with progressively increased mechanical vessel rigidity and stiffness. With age the vascular smooth muscle cells modify their phenotype from contractile to 'synthetic' determining the development of intimal thickening as early as the second decade of life as an adaptive response to forces acting on the arterial wall. The increased permeability observed in intimal thickening could represent the substrate on which low-level atherosclerotic stimuli can promote the development of advanced atherosclerotic lesions. In elderly patients the atherosclerotic plaques tend to be larger with increased vascular stenosis. In these plaques there is a progressive accumulation of both lipids and collagen and a decrease of inflammation. Similarly the plaques from elderly patients show more calcification as compared with those from younger patients. The coronary artery calcium score is a well-established marker of adverse cardiovascular outcomes. The presence of diffuse calcification in a severely stenotic segment probably induces changes in mechanical properties and shear stress of the arterial wall favouring the rupture of a vulnerable lesion in a less stenotic adjacent segment. Oxidative stress and inflammation appear to be the two primary pathological mechanisms of ageing-related endothelial dysfunction even in the absence of clinical disease. Arterial ageing is no longer considered an inexorable process. Only a better understanding of the link between ageing and vascular dysfunction can lead to significant advances in both preventative and therapeutic treatments with the aim that in the future vascular ageing may be halted or even reversed. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
29. SSNp63 controls cellular redox status
- Author
-
Annicchiarico-Petruzzelli, M, Di Daniele, N, and Candi, E
- Subjects
Settore BIO/11 - Published
- 2015
30. Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015
- Author
-
Galluzzi, L., Bravo-San Pedro, J. M., Vitale, Ilio, Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., Baehrecke, E. H., Bazan, N. G., Bertrand, M. J., Bianchi, K., Blagosklonny, M. V., Blomgren, K., Borner, C., Bredesen, D. E., Brenner, C., Campanella, M., Candi, E., Cecconi, F., Chan, F. K., Chandel, N. S., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Dawson, T. M., Dawson, V. L., De Laurenzi, V., De Maria Marchiano, Ruggero, Debatin, K. -M., Di Daniele, N., Dixit, V. M., Dynlacht, B. D., El-Deiry, W. S., Fimia, G. M., Flavell, R. A., Fulda, S., Garrido, C., Gougeon, M. -L., Green, D. R., Gronemeyer, H., Hajnoczky, G., Hardwick, J. M., Hengartner, M. O., Ichijo, H., Joseph, B., Jost, P. J., Kaufmann, T., Kepp, O., Klionsky, D. J., Knight, R. A., Kumar, S., Lemasters, J. J., Levine, B., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Lugli, E., Madeo, F., Malorni, W., Marine, J. -C., Martin, S. J., Martinou, J. -C., Medema, Jan Paul, Meier, P., Melino, S., Mizushima, N., Moll, U., Muñoz-Pinedo, C., Nuñez, G., Oberst, A., Panaretakis, T., Penninger, J. M., Peter, M. E., Piacentini, M., Calzavara Pinton, Piergiacomo, Prehn, J. H., Puthalakath, H., Rabinovich, G. A., Ravichandran, K. S., Rizzuto, R., Rodrigues, C. M., Rubinsztein, D. C., Rudel, T., Shi, Y., Simon, H. -U., Stockwell, B. R., Szabadkai, G., Tait, S. W., Tang, H. L., Tavernarakis, N., Tsujimoto, Y., Vanden Berghe, T., Vandenabeele, P., Villunger, A., Wagner, E. F., Walczak, H., White, E., Wood, W. G., Yuan, J., Zakeri, Z., Zhivotovsky, B., Melino, G., Kroemer, G., Vitale, I., De Maria Marchiano, R. (ORCID:0000-0003-2255-0583), Medema, J. P., Calzavara Pinton, P., Galluzzi, L., Bravo-San Pedro, J. M., Vitale, Ilio, Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., Baehrecke, E. H., Bazan, N. G., Bertrand, M. J., Bianchi, K., Blagosklonny, M. V., Blomgren, K., Borner, C., Bredesen, D. E., Brenner, C., Campanella, M., Candi, E., Cecconi, F., Chan, F. K., Chandel, N. S., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Dawson, T. M., Dawson, V. L., De Laurenzi, V., De Maria Marchiano, Ruggero, Debatin, K. -M., Di Daniele, N., Dixit, V. M., Dynlacht, B. D., El-Deiry, W. S., Fimia, G. M., Flavell, R. A., Fulda, S., Garrido, C., Gougeon, M. -L., Green, D. R., Gronemeyer, H., Hajnoczky, G., Hardwick, J. M., Hengartner, M. O., Ichijo, H., Joseph, B., Jost, P. J., Kaufmann, T., Kepp, O., Klionsky, D. J., Knight, R. A., Kumar, S., Lemasters, J. J., Levine, B., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Lugli, E., Madeo, F., Malorni, W., Marine, J. -C., Martin, S. J., Martinou, J. -C., Medema, Jan Paul, Meier, P., Melino, S., Mizushima, N., Moll, U., Muñoz-Pinedo, C., Nuñez, G., Oberst, A., Panaretakis, T., Penninger, J. M., Peter, M. E., Piacentini, M., Calzavara Pinton, Piergiacomo, Prehn, J. H., Puthalakath, H., Rabinovich, G. A., Ravichandran, K. S., Rizzuto, R., Rodrigues, C. M., Rubinsztein, D. C., Rudel, T., Shi, Y., Simon, H. -U., Stockwell, B. R., Szabadkai, G., Tait, S. W., Tang, H. L., Tavernarakis, N., Tsujimoto, Y., Vanden Berghe, T., Vandenabeele, P., Villunger, A., Wagner, E. F., Walczak, H., White, E., Wood, W. G., Yuan, J., Zakeri, Z., Zhivotovsky, B., Melino, G., Kroemer, G., Vitale, I., De Maria Marchiano, R. (ORCID:0000-0003-2255-0583), Medema, J. P., and Calzavara Pinton, P.
- Abstract
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as 'accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. 'Regulated cell death' (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.
- Published
- 2015
31. p63 controls cell migration and invasion by transcriptional regulation of MTSS1
- Author
-
Giacobbe, A, primary, Compagnone, M, additional, Bongiorno-Borbone, L, additional, Antonov, A, additional, Markert, E K, additional, Zhou, J H, additional, Annicchiarico-Petruzzelli, M, additional, Melino, G, additional, and Peschiaroli, A, additional
- Published
- 2015
- Full Text
- View/download PDF
32. ΔNp63 targets cytoglobin to inhibit oxidative stress-induced apoptosis in keratinocytes and lung cancer
- Author
-
Latina, A, primary, Viticchiè, G, additional, Lena, A M, additional, Piro, M C, additional, Annicchiarico-Petruzzelli, M, additional, Melino, G, additional, and Candi, E, additional
- Published
- 2015
- Full Text
- View/download PDF
33. Cutaneous mosaicism, in KRT1 pI479T patient, caused by the somatic loss of the wild-type allele, leads to the increase in local severity of the disease
- Author
-
Palombo, R., primary, Giannella, E., additional, Didona, B., additional, Annicchiarico-Petruzzelli, M., additional, Melino, G., additional, and Terrinoni, A., additional
- Published
- 2015
- Full Text
- View/download PDF
34. Role of phospholipids in the pathophysiology of the gut-liver axis
- Author
-
Petruzzelli, M., Siersema, P.D., Groen, A.K., Portincasa, P., Erpecum, K.J. van, Moschetta, A., and University Utrecht
- Subjects
Geneeskunde ,bile acids ,hypercholesterolemia ,colon cancer ,indomethacin ,aramchol ,cholesterol ,lipids (amino acids, peptides, and proteins) ,liver ,intestine ,cholelithiasis ,phospholipids - Abstract
Phospholipids represent essential components of bile. Together with bile acids and cholesterol, phospholipids form “mixed micelles”. If sufficient amounts of phospholipids are available, no simple bile acid micelles are present, with prevention of bile acid toxicity and cholesterol crystallization. Apart from their effects in bile, bile acid-phospholipid micelles are also very important for cholesterol solubilization and absorption in the intestine. Intestinal absorption of excess cholesterol is crucial in the pathogenesis of hypercholesterolemia and cardiovascular disease. Finally, some exogenous compounds (e.g. some drugs, like NSAIDs) interact with mixed micelles. In this thesis, we focused on in vitro physical-chemical interactions between phospholipids, bile acids, cholesterol and some exogenous compounds. We also investigated molecular biologic aspects of phospholipids in animal models. We specifically evaluated the following: 1. Treatment and prevention of cholesterol crystallization by Aramchol, a new synthetic bile acid-fatty acid compound (FABAC). 2. Protective effects of phospholipids against toxic effects of non steroidal anti-inflammatory drugs (NSAIDs) in the gastrointestinal tract. 3. Effects of phospholipids on intestinal cholesterol absorption. 4. Role of phospholipids on formation and progression of colon cancer. Employing complementary in vitro model systems, we found no decrease of cholesterol crystallization with Aramchol, nor effects on micellar cholesterol solubilization and micelle-vesicle transitions. Furthermore, we found that adding Aramchol increased the cytotoxicity of bile acid micelles. These deleterious effects were prevented by simultaneous addition of phospholipids. Regarding NSAIDs, we found that indomethacin alone did not exert any toxic effects in vitro. Nevertheless, addition of this NSAID to simple bile acid micelles increased toxicity. Similar to Aramchol, adding phosphatidylcholine strongly reduced toxicity. As for intestinal cholesterol absorption, we showed in vitro that incorporation of phosphatidylcholine or sphingomyelin caused marked retention of cholesterol in the apical compartment of a transwell system with CaCo2 cells, concomitant with a decrease of ABC-A1 mRNA and protein levels. ABC-A1 protein is responsible for transfer of cholesterol from enterocyte to HDL particles. Incorporation of lyso-phosphatidylcholine strongly decreased apical retention of cholesterol, with concomitant increased expression of ABC-A1 and increased transfer of cholesterol to HDL at the basolateral compartment. Our findings may be relevant for prevention and treatment of hypercholesterolemia and cardiovascular disease. Finally, we explored whether phospholipids could be involved in the regeneration of intestinal mucosa and the occurrence of intestinal tumors. We availed of the mdr2 “knockout” mouse (with absent phospholipids in bile) and two complementary models for intestinal cancer (based on administration of carcinogen resp. deletion of the APC gene). In the mdr2 “knockout” mice, numbers and sizes of the intestinal tumors were much less than in control mice. This protective effect was abrogated by feeding a diet containing phospholipids to the mdr2 “knockout” mice. Our findings may be relevant for prevention and treatment of intestinal tumors. In summary, in this thesis we explored physical-chemical aspects and molecular biological effects of phospholipids in complementary in vitro model systems and animal models. This work may increase insight in pathophysiological processes and lead to better potential for prevention and treatment of human disease.
- Published
- 2010
35. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- Author
-
Galluzzi, L, Bravo-San Pedro, Jm, Vitale, I, Aaronson, Sa, Abrams, Jm, Adam, D, Alnemri, E, Altucci, L, Andrews, D, Annicchiarico-Petruzzelli, M, Baehrecke, Eh, Bazan, Ng, Bertrand, Mj, Bianchi, K, Blagosklonny, Mv, Blomgren, K, Borner, C, Bredesen, De, Brenner, C, Campanella, M, Candi, E, Cecconi, F, Chan, Fk, Chandel, N, Cheng, Eh, Chipuk, Je, Cidlowski, Ja, Ciechanover, A, Dawson, Tm, Dawson, Vl, De Laurenzi, V, De Maria Marchiano, Ruggero, Debatin, Km, Di Daniele, N, Dixit, Vm, Dynlacht, Bd, El-Deiry, W, Fimia, Gm, Flavell, Ra, Fulda, S, Garrido, C, Gougeon, Ml, Green, Dr, Gronemeyer, H, Hajnoczky, G, Hardwick, Jm, Hengartner, Mo, Ichijo, H, Joseph, B, Jost, Pj, Kaufmann, T, Kepp, O, Klionsky, Dj, Knight, Ra, Kumar, S, Lemasters, Jj, Levine, B, Linkermann, A, Lipton, Sa, Lockshin, Ra, López-Otín, C, Lugli, E, Madeo, F, Malorni, W, Marine, Jc, Martin, Sj, Martinou, Jc, Medema, Jan Paul, Meier, P, Melino, S, Mizushima, N, Moll, U, Muñoz-Pinedo, C, Nuñez, G, Oberst, A, Panaretakis, T, Penninger, Jm, Peter, Me, Piacentini, M, Calzavara Pinton, Piergiacomo, Prehn, Jh, Puthalakath, H, Rabinovich, Ga, Ravichandran, K, Rizzuto, R, Rodrigues, Cm, Rubinsztein, Dc, Rudel, T, Shi, Y, Simon, Hu, Stockwell, Br, Szabadkai, G, Tait, Sw, Tang, Hl, Tavernarakis, N, Tsujimoto, Y, Vanden Berghe, T, Vandenabeele, P, Villunger, A, Wagner, Ef, Walczak, H, White, E, Wood, Wg, Yuan, J, Zakeri, Z, Zhivotovsky, B, Melino, G, Kroemer, G., De Maria Marchiano R (ORCID:0000-0003-2255-0583), Medema JP, Calzavara Pinton P, Galluzzi, L, Bravo-San Pedro, Jm, Vitale, I, Aaronson, Sa, Abrams, Jm, Adam, D, Alnemri, E, Altucci, L, Andrews, D, Annicchiarico-Petruzzelli, M, Baehrecke, Eh, Bazan, Ng, Bertrand, Mj, Bianchi, K, Blagosklonny, Mv, Blomgren, K, Borner, C, Bredesen, De, Brenner, C, Campanella, M, Candi, E, Cecconi, F, Chan, Fk, Chandel, N, Cheng, Eh, Chipuk, Je, Cidlowski, Ja, Ciechanover, A, Dawson, Tm, Dawson, Vl, De Laurenzi, V, De Maria Marchiano, Ruggero, Debatin, Km, Di Daniele, N, Dixit, Vm, Dynlacht, Bd, El-Deiry, W, Fimia, Gm, Flavell, Ra, Fulda, S, Garrido, C, Gougeon, Ml, Green, Dr, Gronemeyer, H, Hajnoczky, G, Hardwick, Jm, Hengartner, Mo, Ichijo, H, Joseph, B, Jost, Pj, Kaufmann, T, Kepp, O, Klionsky, Dj, Knight, Ra, Kumar, S, Lemasters, Jj, Levine, B, Linkermann, A, Lipton, Sa, Lockshin, Ra, López-Otín, C, Lugli, E, Madeo, F, Malorni, W, Marine, Jc, Martin, Sj, Martinou, Jc, Medema, Jan Paul, Meier, P, Melino, S, Mizushima, N, Moll, U, Muñoz-Pinedo, C, Nuñez, G, Oberst, A, Panaretakis, T, Penninger, Jm, Peter, Me, Piacentini, M, Calzavara Pinton, Piergiacomo, Prehn, Jh, Puthalakath, H, Rabinovich, Ga, Ravichandran, K, Rizzuto, R, Rodrigues, Cm, Rubinsztein, Dc, Rudel, T, Shi, Y, Simon, Hu, Stockwell, Br, Szabadkai, G, Tait, Sw, Tang, Hl, Tavernarakis, N, Tsujimoto, Y, Vanden Berghe, T, Vandenabeele, P, Villunger, A, Wagner, Ef, Walczak, H, White, E, Wood, Wg, Yuan, J, Zakeri, Z, Zhivotovsky, B, Melino, G, Kroemer, G., De Maria Marchiano R (ORCID:0000-0003-2255-0583), Medema JP, and Calzavara Pinton P
- Abstract
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as 'accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. 'Regulated cell death' (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.
- Published
- 2014
36. New role of bile acid metabolism in intestinal bacteria translocation
- Author
-
Petruzzelli, M., primary and Moschetta, A., additional
- Full Text
- View/download PDF
37. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- Author
-
Galluzzi, L, primary, Bravo-San Pedro, J M, additional, Vitale, I, additional, Aaronson, S A, additional, Abrams, J M, additional, Adam, D, additional, Alnemri, E S, additional, Altucci, L, additional, Andrews, D, additional, Annicchiarico-Petruzzelli, M, additional, Baehrecke, E H, additional, Bazan, N G, additional, Bertrand, M J, additional, Bianchi, K, additional, Blagosklonny, M V, additional, Blomgren, K, additional, Borner, C, additional, Bredesen, D E, additional, Brenner, C, additional, Campanella, M, additional, Candi, E, additional, Cecconi, F, additional, Chan, F K, additional, Chandel, N S, additional, Cheng, E H, additional, Chipuk, J E, additional, Cidlowski, J A, additional, Ciechanover, A, additional, Dawson, T M, additional, Dawson, V L, additional, De Laurenzi, V, additional, De Maria, R, additional, Debatin, K-M, additional, Di Daniele, N, additional, Dixit, V M, additional, Dynlacht, B D, additional, El-Deiry, W S, additional, Fimia, G M, additional, Flavell, R A, additional, Fulda, S, additional, Garrido, C, additional, Gougeon, M-L, additional, Green, D R, additional, Gronemeyer, H, additional, Hajnoczky, G, additional, Hardwick, J M, additional, Hengartner, M O, additional, Ichijo, H, additional, Joseph, B, additional, Jost, P J, additional, Kaufmann, T, additional, Kepp, O, additional, Klionsky, D J, additional, Knight, R A, additional, Kumar, S, additional, Lemasters, J J, additional, Levine, B, additional, Linkermann, A, additional, Lipton, S A, additional, Lockshin, R A, additional, López-Otín, C, additional, Lugli, E, additional, Madeo, F, additional, Malorni, W, additional, Marine, J-C, additional, Martin, S J, additional, Martinou, J-C, additional, Medema, J P, additional, Meier, P, additional, Melino, S, additional, Mizushima, N, additional, Moll, U, additional, Muñoz-Pinedo, C, additional, Nuñez, G, additional, Oberst, A, additional, Panaretakis, T, additional, Penninger, J M, additional, Peter, M E, additional, Piacentini, M, additional, Pinton, P, additional, Prehn, J H, additional, Puthalakath, H, additional, Rabinovich, G A, additional, Ravichandran, K S, additional, Rizzuto, R, additional, Rodrigues, C M, additional, Rubinsztein, D C, additional, Rudel, T, additional, Shi, Y, additional, Simon, H-U, additional, Stockwell, B R, additional, Szabadkai, G, additional, Tait, S W, additional, Tang, H L, additional, Tavernarakis, N, additional, Tsujimoto, Y, additional, Vanden Berghe, T, additional, Vandenabeele, P, additional, Villunger, A, additional, Wagner, E F, additional, Walczak, H, additional, White, E, additional, Wood, W G, additional, Yuan, J, additional, Zakeri, Z, additional, Zhivotovsky, B, additional, Melino, G, additional, and Kroemer, G, additional
- Published
- 2014
- Full Text
- View/download PDF
38. Apoptosis in neuroblastomas induced by interferon-gamma involves the CD95/CD95L pathway
- Author
-
Annicchiarico Petruzzelli, M, Bernassola, F, Lovat, P, Redfern, C, Pearson, A, and Melino, G
- Subjects
neuroblastoma ,interferon gamma ,Settore BIO/11 ,apoptosis ,CD95 ,CD95L - Published
- 2001
39. Role of phospholipids in the pathophysiology of the gut-liver axis
- Author
-
Siersema, P.D., Groen, A.K., Portincasa, P., Erpecum, K.J. van, Moschetta, A., Petruzzelli, M., Siersema, P.D., Groen, A.K., Portincasa, P., Erpecum, K.J. van, Moschetta, A., and Petruzzelli, M.
- Published
- 2010
40. Fibroblast growth and polymorphonuclear granulocyte activation in the presence of new biologically active sol-gel glass
- Author
-
Palumbo, G., Avigliano, L., Strukul, Giorgio, Pinna, Francesco, Del Principe, D., D'Angelo, I., Annicchiarico Petruzzelli, M., Locardi, B., and Rosato, N.
- Published
- 1997
41. MicroRNA-203 contributes to skin re-epithelialization
- Author
-
Viticchiè, G, primary, Lena, A M, additional, Cianfarani, F, additional, Odorisio, T, additional, Annicchiarico-Petruzzelli, M, additional, Melino, G, additional, and Candi, E, additional
- Published
- 2012
- Full Text
- View/download PDF
42. Novel transglutaminase 1 mutations in patients affected by lamellar ichthyosis
- Author
-
Terrinoni, A, primary, Serra, V, additional, Codispoti, A, additional, Talamonti, E, additional, Bui, L, additional, Palombo, R, additional, Sette, M, additional, Campione, E, additional, Didona, B, additional, Annicchiarico-Petruzzelli, M, additional, Zambruno, G, additional, Melino, G, additional, and Candi, E, additional
- Published
- 2012
- Full Text
- View/download PDF
43. Chemical and geochemical characterisation of a disused red brick factory area of central Italy
- Author
-
Petruzzelli, D., primary, Petruzzelli, V., additional, Basile, T., additional, Petruzzelli, M., additional, Petrella, A., additional, and Maggiore, M., additional
- Published
- 2011
- Full Text
- View/download PDF
44. p38α blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1α- to FoxO-dependent transcription
- Author
-
Chiacchiera, F, primary, Matrone, A, additional, Ferrari, E, additional, Ingravallo, G, additional, Lo Sasso, G, additional, Murzilli, S, additional, Petruzzelli, M, additional, Salvatore, L, additional, Moschetta, A, additional, and Simone, C, additional
- Published
- 2009
- Full Text
- View/download PDF
45. Taurodeoxycholate-induced intestinal injury is modulated by oxidative stress-dependent pre-conditioning like mechanisms
- Author
-
PORTINCASA, P, primary, GRATTAGLIANO, I, additional, PETRUZZELLI, M, additional, MOSCHETTA, A, additional, DEBELLIS, L, additional, and PALASCIANO, G, additional
- Published
- 2008
- Full Text
- View/download PDF
46. Signal-dependent control of autophagy and cell death in colorectal cancer cell: the role of the p38 pathway
- Author
-
Chiacchiera, F., primary, Ferrari, E., additional, Matrone, A., additional, Losasso, G., additional, Murzilli, S., additional, Petruzzelli, M., additional, Ingravallo, G., additional, Moschetta, A., additional, and Simone, C., additional
- Published
- 2008
- Full Text
- View/download PDF
47. Characterisation of a human glioblastoma cell line (LI) expressing hypothalamic and pituitary hormones
- Author
-
Savarese, A, Annicchiarico Petruzzelli, M, Citro, G, Zupi, G, Spagnoli, Lg, Colantoni, A, Vernole, P, Stephanou, A, Knight, R, and Guerrieri, P
- Subjects
Male ,Microscopy ,Cultured ,Pro-Opiomelanocortin ,Blotting ,Nervous System Neoplasms ,Hypothalamus ,Tretinoin ,DNA ,Glioma ,Middle Aged ,Settore MED/08 - Anatomia Patologica ,Growth Hormone-Releasing Hormone ,Electron ,Hormones ,Tumor Cells ,Pituitary Hormones ,Cytogenetics ,Phenotype ,Insulin-Like Growth Factor II ,Blotting, Northern ,Humans ,DNA, Neoplasm ,Tumor Cells, Cultured ,Microscopy, Electron ,Neoplasm ,Northern - Published
- 1992
48. Characterization of four newly established melanoma cell lines
- Author
-
Melino, G, SINIBALDI VALLEBONA, P, Spagnoli, L, Vernole, P, Rasi, G, D'Atri, S, Tartaglia, L, Catani, Mv, Annichiarico Petruzzelli, M, Finazzi Agrò, A, and Garaci, E
- Subjects
Settore MED/07 - Microbiologia e Microbiologia Clinica - Published
- 1992
49. Biological aspects of HIV infection
- Author
-
Macchi, B., Petruzzelli, M. A., and Vincenzo De Laurenzi
- Subjects
Adult ,Male ,Substance-Related Disorders ,T-Lymphocytes ,review ,HIV Infections ,HIV Antibodies ,Hemophilia A ,acquired immune deficiency syndrome ,Human immunodeficiency virus antibody ,addiction ,adult ,genetics ,hemophilia A ,homosexuality ,human ,Human immunodeficiency virus ,Human immunodeficiency virus infection ,immunology ,immunosuppressive treatment ,male ,T lymphocyte ,Acquired Immunodeficiency Syndrome ,HIV ,Homosexuality ,Human ,Immunosuppression ,Support, Non-U.S. Gov't ,Non-U.S. Gov't ,Settore MED/07 - Microbiologia e Microbiologia Clinica ,Support - Published
- 1992
50. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.
- Author
-
Galluzzi, L, Bravo-San Pedro, J M, Vitale, I, Aaronson, S A, Abrams, J M, Adam, D, Alnemri, E S, Altucci, L, Andrews, D, Annicchiarico-Petruzzelli, M, Baehrecke, E H, Bazan, N G, Bertrand, M J, Bianchi, K, Blagosklonny, M V, Blomgren, K, Borner, C, Bredesen, D E, Brenner, C, and Campanella, M
- Subjects
CELL death inhibition ,CELL-mediated cytotoxicity ,GENETIC code ,GENETIC transcription ,GENETIC engineering research - Abstract
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as 'accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. 'Regulated cell death' (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.