Search

A single taking by children of eggs' white in an amount of 2 g/kg of the body weight resulted in that the blood plasma experienced a decline in the relative content of phosphatidylserine, lecithin and a rise in the level of phosphatidylethanolamine. In the membranes of erythrocytes there occurred a rise in the proportion of phosphatidylserine, phosphatidylethanolamine and a fall of the share of lecithin and sphyngomyelin. In the composition of beta-lipoproteins the level of phosphatidylethanolamine was up with a marked drop of phosphatidylserine. Variations in the content of sphyngomyelin and lecithin showed no characteristic features.

Children with febril and epileptic convulsion during different periods of the disease demonstrate changes in the correlation of phospholipids in the blood plasma. These changes are mainly of a general character and do not depend upon the genesis of convulsions. The largest differences were seen in the lysolecithine level. These data probably indicate to a certain qualitative basis in the phospholipid metabolism in children with this pathology or may be related to a retardation in the formation of the structure of phospholipid metabolism.

Effects of alpha-tocopherol, unithiol and mysclerone on lipid peroxidation, activity of phospholipases and the state of a body antioxidant systems were studied in 115 patients with glomerulonephritis. Administration of these drugs caused a decrease in the content of peroxides in blood and urine, a decrease in activity of endogenous phospholipases, an increase in the content of antioxidants as well as in the activity of antioxidant enzymes. Different effects of the preparations on various steps of lipid peroxidation as well as on the activity of phospholipases and antioxidant enzymes were shown.

It was found that alpha-tocopherol unithiol (during both monotherapy and combined treatment), misclerone, metindol, vegetable oil considerably increase effectiveness in therapy and prevention of aggravations of diffuse glomerulonephritis in children.

Distinct increase in content of lysophosphatidyl choline, dehydrocholesterol, decrease in concentration of phosphatidyl ethanolamine simultaneously with high level of diene conjugates and Schiff bases were found in children with hormone-resistant form of nephrotic glomerulonephritis as compared with children suffering from a hormone-dependent form of the disease. Peroxidation of membrane lipids appears to cause a destabilization of cell membranes, which is responsible for development of hormone-resistance.

A study was made of the effect of vegetable fats on lipid metabolism and free radical oxidation, phospholipase activity and antioxidant content in 43 children suffering from chronic glomerulonephritis. After intake of a vegetative fat in a dose of 2 g/kg bw for 7 days the sick children demonstrated a significant rise in the level of total lipids in red cells and in their excretion with urine. This was in a good agreement with an increase in phospholipase activity in blood and diminution of lipid peroxides in red cell membranes. The reaction of antioxidant enzymes metabolizing hydrogen peroxide was different. Catalase activity in urine was elevated, whereas urine peroxidase activity was decreased. All these changes gave rise to a decrease in the pool of peroxide radicals which correlated with the time course of hydroperoxides. The biochemical data indicate that lipids contained by vegetative fats may be regarded as treatment-and-dietetic factor in multiple modality therapy of children with renal diseases.