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3. Safety and Effectiveness of Pulsed Field Ablation for Atrial Fibrillation in Patients With Heart Failure

Author

Turagam, Mohit K., Neuzil, Petr, Schmidt, Boris, Reichlin, Tobias, Neven, Kars, Metzner, Andreas, Hansen, Jim, Blaauw, Yuri, Maury, Philippe, Arentz, Thomas, Sommer, Philipp, Anic, Ante, Anselme, Frederic, Boveda, Serge, Deneke, Tom, Willems, Stephan, van der Voort, Pepijn, Tilz, Roland, Funasako, Moritoshi, Scherr, Daniel, Wakili, Reza, Steven, Daniel, Kautzner, Josef, Vijgen, Johan, Jais, Pierre, Petru, Jan, Chun, Julian, Roten, Laurent, Füting, Anna, Lemoine, Marc D., Ruwald, Martin, Mulder, Bart A., Rollin, Anne, Lehrmann, Heiko, Fink, Thomas, Jurisic, Zrinka, Chaumont, Corentin, Adelino, Raquel, Nentwich, Karin, Gunawardene, Melanie, Ouss, Alexandre, Heeger, Christian-Hendrik, Manninger, Martin, Bohnen, Jan-Eric, Sultan, Arian, Peichl, Petr, Koopman, Pieter, Derval, Nicolas, Kueffer, Thomas, Reinsch, Nico, and Reddy, Vivek Y.

Published
2024
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5. Impact of Left Atrial Posterior Wall Ablation During Pulsed-Field Ablation for Persistent Atrial Fibrillation

Author

Turagam, Mohit K., Neuzil, Petr, Schmidt, Boris, Reichlin, Tobias, Neven, Kars, Metzner, Andreas, Hansen, Jim, Blaauw, Yuri, Maury, Philippe, Arentz, Thomas, Sommer, Philipp, Anic, Ante, Anselme, Frederic, Boveda, Serge, Deneke, Tom, Willems, Stephan, van der Voort, Pepijn, Tilz, Roland, Funasako, Moritoshi, Scherr, Daniel, Wakili, Reza, Steven, Daniel, Kautzner, Josef, Vijgen, Johan, Jais, Pierre, Petru, Jan, Chun, Julian, Roten, Laurent, Füting, Anna, Lemoine, Marc D., Ruwald, Martin, Mulder, Bart A., Rollin, Anne, Lehrmann, Heiko, Fink, Thomas, Jurisic, Zrinka, Chaumont, Corentin, Adelino, Raquel, Nentwich, Karin, Gunawardene, Melanie, Ouss, Alexandre, Heeger, Christian-Hendrik, Manninger, Martin, Bohnen, Jan-Eric, Sultan, Arian, Peichl, Petr, Koopman, Pieter, Derval, Nicolas, Kueffer, Thomas, Reinsch, Nico, and Reddy, Vivek Y.

Published
2024
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10. Efficacy and safety of novel temperature-controlled radiofrequency ablation system during pulmonary vein isolation in patients with paroxysmal atrial fibrillation: TRAC-AF study

Author

Starek, Zdenek, Lehar, Frantisek, Jez, Jiri, Pesl, Martin, Neuzil, Petr, Sediva, Lucie, Petru, Jan, Dujka, Libor, Funasako, Moritoshi, Kautzner, Josef, Peichl, Petr, Aldhoon, Bashar, Albenque, Jean-Paul, Combes, Stephane, Boveda, Serge, Dukkipati, Srinivas R., and Reddy, Vivek Y.

Published
2022
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11. Safety and Effectiveness of Pulsed Field Ablation to Treat Atrial Fibrillation: One-Year Outcomes From the MANIFEST-PF Registry

Author

Turagam, Mohit K., Neuzil, Petr, Schmidt, Boris, Reichlin, Tobias, Neven, Kars, Metzner, Andreas, Hansen, Jim, Blaauw, Yuri, Maury, Philippe, Arentz, Thomas, Sommer, Philipp, Anic, Ante, Anselme, Frederic, Boveda, Serge, Deneke, Tom, Willems, Stephan, van der Voort, Pepijn, Tilz, Roland, Funasako, Moritoshi, Scherr, Daniel, Wakili, Reza, Steven, Daniel, Kautzner, Josef, Vijgen, Johan, Jais, Pierre, Petru, Jan, Chun, Julian, Roten, Laurent, Füting, Anna, Lemoine, Marc D., Ruwald, Martin, Mulder, Bart A, Rollin, Anne, Lehrmann, Heiko, Fink, Thomas, Jurisic, Zrinka, Chaumont, Corentin, Adelino, Raquel, Nentwich, Karin, Gunawardene, Melanie, Ouss, Alexandre, Heeger, Christian-Hendrik, Manninger, Martin, Bohnen, Jan-Eric, Sultan, Arian, Peichl, Petr, Koopman, Pieter, Derval, Nicolas, Kueffer, Thomas, Rahe, Gilbert, and Reddy, Vivek Y.

Published
2023
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15. Novel Low-Voltage MultiPulse Therapy to Terminate Atrial Fibrillation

Author

Ng, Fu Siong, Toman, Ondřej, Petru, Jan, Peichl, Petr, Winkle, Roger A., Reddy, Vivek Y., Neuzil, Petr, Mead, R. Hardwin, Qureshi, Norman A., Whinnett, Zachary I., Bourn, David W., Shelton, M. Brent, Kautzner, Josef, Sharma, Arjun D., Hocini, Meleze, Haïssaguerre, Michel, Peters, Nicholas S., and Efimov, Igor R.

Published
2021
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24. Clinical Outcomes by Sex After Pulsed Field Ablation of Atrial Fibrillation

Author

Turagam, Mohit K., primary, Neuzil, Petr, additional, Schmidt, Boris, additional, Reichlin, Tobias, additional, Neven, Kars, additional, Metzner, Andreas, additional, Hansen, Jim, additional, Blaauw, Yuri, additional, Maury, Philippe, additional, Arentz, Thomas, additional, Sommer, Philipp, additional, Anic, Ante, additional, Anselme, Frederic, additional, Boveda, Serge, additional, Deneke, Tom, additional, Willems, Stephan, additional, van der Voort, Pepijn, additional, Tilz, Roland, additional, Funasako, Moritoshi, additional, Scherr, Daniel, additional, Wakili, Reza, additional, Steven, Daniel, additional, Kautzner, Josef, additional, Vijgen, Johan, additional, Jais, Pierre, additional, Petru, Jan, additional, Chun, Julian, additional, Roten, Laurent, additional, Füting, Anna, additional, Lemoine, Marc D., additional, Ruwald, Martin, additional, Mulder, Bart A., additional, Rollin, Anne, additional, Lehrmann, Heiko, additional, Fink, Thomas, additional, Jurisic, Zrinka, additional, Chaumont, Corentin, additional, Adelino, Raquel, additional, Nentwich, Karin, additional, Gunawardene, Melanie, additional, Ouss, Alexandre, additional, Heeger, Christian-Hendrik, additional, Manninger, Martin, additional, Bohnen, Jan-Eric, additional, Sultan, Arian, additional, Peichl, Petr, additional, Koopman, Pieter, additional, Derval, Nicolas, additional, Kueffer, Thomas, additional, and Reddy, Vivek Y., additional

Published
2023
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28. Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Author

Ekanem, Emmanuel, Neuzil, Petr, Reichlin, Tobias, Kautzner, Joseph, van der Voort, Pepijn, Jais, Pierre, Chierchia, Gian-Battista, Bulava, Alan, Blaauw, Yuri, Skala, Tomas, Fiala, Martin, Duytschaever, Mattias, Szeplaki, Gabor, Schmidt, Boris, Massoullie, Grégoire, Neven, Kars, Thomas, Olivier, Vijgen, Johan, Gandjbakhch, Estelle, Scherr, Daniel, Johannessen, Arne, Keane, David, Boveda, Serge, Maury, Philippe, García-Bolao, Ignacio, Anic, Ante, Hansen, Peter Steen, Raczka, Franck, Lepillier, Antoine, Guyomar, Yves, Gupta, Dhiraj, Van Opstal, Jurren, Defaye, Pascal, Sticherling, Christian, Sommer, Philipp, Kucera, Pavel, Osca, Joaquin, Tabrizi, Fariborz, Roux, Antoine, Gramlich, Michael, Bianchi, Stefano, Adragão, Pedro, Solimene, Francesco, Tondo, Claudio, Russo, Antonio Dello, Schreieck, Jürgen, Luik, Armin, Rana, Obaida, Frommeyer, Gerrit, Anselme, Frédéric, Kreis, Ingo, Rosso, Raphael, Metzner, Andreas, Geller, Laszlo, Baldinger, Samuel H., Ferrero, Angel, Willems, Stephan, Goette, Andreas, Mellor, Greg, Mathew, Shibu, Szumowski, Lukasz, Tilz, Roland, Iacopino, Saverio, Jacobsen, Peter Karl, George, Andrikopoulos, Osmancik, Pavel, Spitzer, Stefan, Balasubramaniam, Richard, Parwani, Abdul Shokor, Deneke, Thomas, Glowniak, Andrzej, Rossillo, Antonio, Pürerfellner, Helmut, Duncker, David, Reil, Peter, Arentz, Thomas, Steven, Daniel, Olalla, Juan José, de Jong, Jonas S. S. G., Wakili, Reza, Abbey, Selim, Timo, Gottschling, Asso, Antonio, Wong, Tom, Pierre, Bertrand, Ewertsen, Niels Christian, Bergau, Leonard, Lozano-Granero, Cristina, Rivero, Maximo, Breitenstein, Alexander, Inkovaara, Jaakko, Fareh, Samir, Latcu, Decebal Gabriel, Linz, Dominik, Müller, Patrick, Ramos-Maqueda, Javier, Beiert, Thomas, Themistoclakis, Sakis, Meininghaus, Dirk Grosse, Stix, Günter, Tzeis, Stylianos, Baran, Jakub, Almroth, Henrik, Munoz, Daniel Rodriguez, de Sousa, João, Efremidis, Michalis, Balsam, Pawel, Petru, Jan, Küffer, Thomas, Peichl, Petr, Dekker, Lukas, Della Rocca, Domenico G., Moravec, Ondrej, Funasako, Moritoshi, Knecht, Sebastien, Jauvert, Gael, Chun, Julian, Eschalier, Romain, Füting, Anna, Zhao, Alexandre, Koopman, Pieter, Laredo, Mikael, Manninger, Martin, Hansen, Jim, O’Hare, Daniel, Rollin, Anne, Jurisic, Zrinka, Fink, Thomas, Chaumont, Corentin, Rillig, Andreas, Gunawerdene, Melanie, Martin, Claire, Kirstein, Bettina, Nentwich, Karin, Lehrmann, Heiko, Sultan, Arian, Bohnen, Jan, Turagam, Mohit K., and Reddy, Vivek Y.

Abstract

Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myocardial tissue ablation without damage to adjacent structures. Here in the MANIFEST-17K study we assessed the safety of PFA by studying the post-approval use of this treatment modality. Of the 116 centers performing post-approval PFA with a pentaspline catheter, data were received from 106 centers (91.4% participation) regarding 17,642 patients undergoing PFA (mean age 64, 34.7% female, 57.8% paroxysmal AF and 35.2% persistent AF). No esophageal complications, pulmonary vein stenosis or persistent phrenic palsy was reported (transient palsy was reported in 0.06% of patients; 11 of 17,642). Major complications, reported for ~1% of patients (173 of 17,642), were pericardial tamponade (0.36%; 63 of 17,642) and vascular events (0.30%; 53 of 17,642). Stroke was rare (0.12%; 22 of 17,642) and death was even rarer (0.03%; 5 of 17,642). Unexpected complications of PFA were coronary arterial spasm in 0.14% of patients (25 of 17,642) and hemolysis-related acute renal failure necessitating hemodialysis in 0.03% of patients (5 of 17,642). Taken together, these data indicate that PFA demonstrates a favorable safety profile by avoiding much of the collateral damage seen with conventional thermal ablation. PFA has the potential to be transformative for the management of patients with AF.

Published
2024
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29. First-in-human clinical series of a novel conformable large-lattice pulsed field ablation catheter for pulmonary vein isolation.

Author

Reddy, Vivek Y, Anter, Elad, Peichl, Petr, Rackauskas, Gediminas, Petru, Jan, Funasako, Moritoshi, Koruth, Jacob S, Marinskis, Germanas, Turagam, Mohit, Aidietis, Audrius, Kautzner, Josef, Natale, Andrea, and Neuzil, Petr

Abstract

Aims Pulsed field ablation (PFA) has significant advantages over conventional thermal ablation of atrial fibrillation (AF). This first-in-human, single-arm trial to treat paroxysmal AF (PAF) assessed the efficiency, safety, pulmonary vein isolation (PVI) durability and one-year clinical effectiveness of an 8 Fr, large-lattice, conformable single-shot PFA catheter together with a dedicated electroanatomical mapping system. Methods and results After rendering the PV anatomy, the PFA catheter delivered monopolar, biphasic pulse trains (5–6 s per application; ∼4 applications per PV). Three waveforms were tested: PULSE1, PULSE2, and PULSE3. Follow-up included ECGs, Holters at 6 and 12 months, and symptomatic and scheduled transtelephonic monitoring. The primary and secondary efficacy endpoints were acute PVI and post-blanking atrial arrhythmia recurrence, respectively. Invasive remapping was conducted ∼75 days post-ablation. At three centres, PVI was performed by five operators in 85 patients using PULSE1 (n = 30), PULSE2 (n = 20), and PULSE3 (n = 35). Acute PVI was achieved in 100% of PVs using 3.9 ± 1.4 PFA applications per PV. Overall procedure, transpired ablation, PFA catheter dwell and fluoroscopy times were 56.5 ± 21.6, 10.0 ± 6.0, 19.1 ± 9.3, and 5.7 ± 3.9 min, respectively. No pre-defined primary safety events occurred. Upon remapping, PVI durability was 90% and 99% on a per-vein basis for the total and PULSE3 cohort, respectively. The Kaplan–Meier estimate of one-year freedom from atrial arrhythmias was 81.8% (95% CI 70.2–89.2%) for the total, and 100% (95% CI 80.6–100%) for the PULSE3 cohort. Conclusion Pulmonary vein isolation (PVI) utilizing a conformable single-shot PFA catheter to treat PAF was efficient, safe, and effective, with durable lesions demonstrated upon remapping. [ABSTRACT FROM AUTHOR]

Published
2024
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33. PO-04-005 LEFT CIRCUMFLEX ARTERY VASOSPASM DURING PULSED FIELD ABLATION AT THE MITRAL ISTHMUS: CHARACTERIZATION OF TIME-TO-RESOLUTION

Author

Zhang, Chi, primary, Neuzil, Petr, additional, Petru, Jan, additional, Funasako, Moritoshi, additional, Hala, Pavel, additional, Chovanec, Milan, additional, Janotka, Marek, additional, Kralovec, Stepan, additional, Kopriva, Karel, additional, Turagam, Mohit K., additional, Musikantow, Daniel R., additional, and Reddy, Vivek Y., additional

Published
2023
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37. AB-452675-1 ELECTROPHYSIOLOGICAL FINDINGS DURING REDO PROCEDURES AFTER PULSED FIELD ABLATION USING A PENTASPLINE CATHETER TO TREAT ATRIAL FIBRILLATION IN ROUTINE CLINICAL PRACTIC

Author

Petru, Jan, primary, Funasako, Moritoshi, additional, Reddy, Vivek Y., additional, Sediva, Lucie, additional, Skoda, Jan, additional, Hala, Pavel, additional, Chovanec, Milan, additional, Janotka, Marek, additional, Mudroch, Martin, additional, and Neuzil, Petr, additional

Published
2023
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38. PO-01-192 USE OF A LARGE-FOOTPRINT FOCAL LATTICE CATHETER FOR MAPPING AND ABLATION OF ATRIAL FLUTTERS

Author

Musikantow, Daniel R., primary, Peichl, Petr, additional, Anter, Elad, additional, Rackauskas, Gediminas, additional, Petru, Jan, additional, Funasako, Moritoshi, additional, Minami, Kentaro, additional, Koruth, Jacob S., additional, Natale, Andrea, additional, Jais, Pierre, additional, Marinskis, Germanas, additional, Aidietis, Audrius, additional, Kautzner, Josef, additional, Neuzil, Petr, additional, and Reddy, Vivek Y., additional

Published
2023
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39. AB-452675-4 CORONARY ARTERIAL SPASM DURING CAVO-TRICUSPID ISTHMUS ABLATION WITH A NOVEL FOCAL PULSED FIELD ABLATION CATHETER: FINDINGS FROM CORONARY ANGIOGRAPHY AND FRACTIONAL FLOW RESERVE MEASUREMENTS

Author

Malyshev, Yury, primary, Neuzil, Petr, additional, Petru, Jan, additional, Funasako, Moritoshi, additional, Kralovec, Stepan, additional, Skoda, Jan, additional, Schneider, Christopher, additional, Achyutha, Anitha, additional, Vanderper, Annelies, additional, Turagam, Mohit K., additional, and Reddy, Vivek Y., additional

Published
2023
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40. PO-03-006 CHARACTERIZATION OF RIGHT CORONARY ARTERY VASOSPASM DURING RADIOFREQUENCY ABLATION AT THE CAVO-TRICUSPID ISTHMUS

Author

Zhang, Chi, primary, Neuzil, Petr, additional, Petru, Jan, additional, Funasako, Moritoshi, additional, Hala, Pavel, additional, Chovanec, Milan, additional, Janotka, Marek, additional, Kralovec, Stepan, additional, Kopriva, Karel, additional, Turagam, Mohit K., additional, Musikantow, Daniel R., additional, Koruth, Jacob S., additional, Dukkipati, Srinivas R., additional, and Reddy, Vivek Y., additional

Published
2023
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41. AB-453070-2 : A RANDOMIZED CONTROLLED TRIAL OF ELECTROGRAPHIC FLOW-GUIDED ABLATION IN REDO PATIENTS WITH NON-PAROXYSMAL ATRIAL FIBRILLATION

Author

Reddy, Vivek Y., primary, Neuzil, Petr, additional, Langbein, Anke, additional, Petru, Jan, additional, Funasako, Moritoshi, additional, Dinshaw, Leon, additional, Wijchers, Sip, additional, Bhagwandien, Rohit, additional, Rillig, Andreas, additional, Spitzer, Stefan G., additional, Metzner, Andreas, additional, Kong, Melissa H., additional, and Szili-Torok, Tamas, additional

Published
2023
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42. LB-456089-2 LONG-TERM CLINICAL OUTCOMES OF PULSED FIELD ABLATION TO TREAT PATIENTS WITH PAROXYSMAL ATRIAL FIBRILLATION

Author

Musikantow, Daniel R., primary, Neuzil, Petr, additional, Anic, Ante, additional, Balin, Paul, additional, Petru, Jan, additional, Funasako, Moritoshi, additional, Chovanec, Milan, additional, Sediva, Lucie, additional, Breskovic, Toni, additional, Sikiric, Ivan, additional, Lisica, Lucija, additional, Jurisic, Zrinka, additional, Jais, Pierre, additional, and Reddy, Vivek Y., additional

Published
2023
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44. MP-453081-7 A COMPARISON OF LEFT CIRCUMFLEX CORONARY VASOSPASM BETWEEN RADIOFREQUENCY ABLATION AND PULSED FIELD ABLATION AT THE MITRAL ISTHMUS

Author

Zhang, Chi, primary, Neuzil, Petr, additional, Petru, Jan, additional, Funasako, Moritoshi, additional, Hala, Pavel, additional, Chovanec, Milan, additional, Janotka, Marek, additional, Kralovec, Stepan, additional, Kopriva, Karel, additional, Turagam, Mohit K., additional, Musikantow, Daniel R., additional, Koruth, Jacob S., additional, Dukkipati, Srinivas R., additional, and Reddy, Vivek Y., additional

Published
2023
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45. PO-01-195 PHENOTYPING PERSISTENT AF WITH ELECTROGRAPHIC FLOW MAPPING

Author

Reddy, Vivek Y., primary, Castellano, Steven, additional, Szili-Torok, Tamas, additional, Petru, Jan, additional, Funasako, Moritoshi, additional, Hoogendijk, Mark, additional, Wijchers, Sip, additional, Spitzer, Stefan G., additional, Rillig, Andreas, additional, Neuzil, Petr, additional, and Kong, Melissa H., additional

Published
2023
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49. Assessment of the Capacity of Roads Weaving Segments

Author

Mahdalova Ivana, Petru Jan, and Krivda Vladislav

Subjects
weaving segment, capacity assessment, weaving segment operation, level of service (los), Transportation and communication, K4011-4343
Abstract

Driving style is affected by development of cars and it has influence on the capacity of designed elements of roads and highways. Therefore, based on research, more accurate methods for assessing the capacity of road infrastructure are being developed. This paper presents the results of the research of weaving segments. It is focused on capacity assessment of these sections within the Czech Republic. Attention is focused especially on weaving segments in urban conditions with high traffic volume and on road sections with a speed limit less than 80 km per hour. Research verified the possibility of using these purposes by existing methodology developed for roads with a speed limit up to 80 km per hour.

Published
2017
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50. Paroxysmal Atrial Fibrillation Ablation Using a Novel Variable-Loop Biphasic Pulsed Field Ablation Catheter Integrated With a 3-Dimensional Mapping System: 1-Year Outcomes of the Multicenter inspIRE Study

Author

Duytschaever, Mattias, primary, De Potter, Tom, additional, Grimaldi, Massimo, additional, Anic, Ante, additional, Vijgen, Johan, additional, Neuzil, Petr, additional, Van Herendael, Hugo, additional, Verma, Atul, additional, Skanes, Allan, additional, Scherr, Daniel, additional, Pürerfellner, Helmut, additional, Rackauskas, Gediminas, additional, Jaïs, Pierre, additional, Reddy, Vivek Y., additional, Natale, Andrea, additional, Di Biase, Luigi, additional, Knecht, Sebastien, additional, Petru, Jan, additional, Kollias, Georgios, additional, Lukac, Peter, additional, Hansen, Jim, additional, and Phlips, Thomas, additional

Published
2023
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