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Multiplane iterative phase retrieval is a promising approach to diffraction imaging, which accurately determines the topographic and internal characteristics of various objects. Nevertheless, the detection systems used often have a limited dynamic range, resulting in overexposure of recorded intensity distributions. In this Letter, we present a novel, to the best of our knowledge, reconstruction algorithm that inpaints saturated areas on the measured intensity datasets and reliably retrieves wave complex amplitude. The proposed technique can be used in various spectral ranges, while we have tested it in the terahertz frequency range, where the problem of sources and detectors is most acute. We show that retrieved amplitude and phase distributions have a quality comparable to that of the images reconstructed from the reference high dynamic range technique. Herewith, the proposed approach seriously simplifies the process of data acquisition, what expands the possibilities in the design of measurement tools and studies of dynamic scenes.

We demonstrate the opportunities of photogrammetry in digitizing information about objects by acquiring a set of photographic images captured from three-dimensional scenes, which are reconstructed from volume reflection holograms. The corresponding requirements are determined for both recording the display hologram and digitizing the information reconstructed from it by photogrammetry. They include the choice of the radiation source used to reconstruct the object wave from the hologram; requirements for object positioning when recording a display hologram relative to the recording medium; and requirements for the glare minimization procedure during the construction of a photogrammetric three-dimensional model.

This discussion paper highlights the potential of display holograms in the storage of information about objects' shape. The images recorded and reconstructed from holograms have high visual appeal, and the holographic carrier has far higher information capacity than other storage media. One hindrance to the application of display holograms is the inadequate development of techniques for digitizing information from them, which is compounded by insufficient analysis and discussion of existing approaches. In this review, we provide a historical retrospective of the use of display holography to save comprehensive information on object morphology. We also discuss existing and emerging technologies for converting information into a digital format, addressing one of the most serious challenges to the widespread use of display holography. Potential applications of these technologies are also analyzed.

The paper presents the results of a comprehensive study on the optimization of independent amplitude and phase wavefront manipulation which is implemented using a binary digital micromirror device. The study aims to investigate the spatial resolution and quantization achievable using this approach and its optimization based on the parameters of the target complex wave and the modulation error estimation. Based on a statistical analysis of the data, an algorithm for selecting parameters (carrier frequency of binary pattern and aperture for the first diffraction order filtering) that ensures the optimal quality of the modulated wavefront was developed. The algorithm takes into account the type of modulation, that is, amplitude, phase, or amplitude-phase, the size of the encoded distribution, and its requirements for spatial resolution and quantization. The results of the study will greatly contribute to the improvement of modulated wavefront quality in various applications with different requirements for spatial resolution and quantization., (© 2022. The Author(s).)

In this paper, we detail a phase-shift implementation in a rotated plane-parallel plate (PPP). Considering the phase-shifting digital holography application, we provide a more precise phase-shift estimation based on PPP thickness, rotation, and mutual inclination of reference and object wavefronts. We show that phase retardation uncertainty implemented by the rotated PPP in a simple configuration is less than the uncertainty of a traditionally used piezoelectric translator. Physical experiments on a phase test target verify the high quality of phase reconstruction.

We report on the application of time-resolved inline digital holography in the study of the nonlinear optical properties of quantum dots deposited onto sample glass. The Fresnel diffraction patterns of the probe pulse due to noncollinear degenerate phase modulation induced by a femtosecond pump pulse were extracted from the set of inline digital holograms and analyzed. The absolute values of the nonlinear refractive index of both the sample glass substrate and the deposited layer of quantum dots were evaluated using the proposed technique. To characterize the inhomogeneous distribution of the samples' nonlinear optical properties, we proposed plotting an optical nonlinearity map calculated as a local standard deviation of the diffraction pattern intensities induced by noncollinear degenerate phase modulation.

We present a holographic detection module to measure the spatially resolved distribution of pulsed terahertz field in a single scan by a motorized translation stage, responsible for the time delay. All mounts of the optical elements of the module are easily reproduced by 3D printing and attached to the optical cage system. The latter greatly simplifies the measurement procedure, allowing the experimenter to move and adjust the detection system as a single device. The developed mounts are made universal and can be used in other setups. We have made 3D models available as open-source hardware. The module is based on an electro-optical detection scheme with wide-aperture ZnTe crystal, crossed polarizers, and a matrix photodetector. The validation of its operability was performed with two experiments to measure the spatial distribution of the unperturbed field from the generator and the vortex field formed by the spiral phase plate. Optical vortices with multiple topological charges of 2-4 were detected on spectral components in the range from 0.3 to 1.1 THz. In addition, we have detailed the alignment process of terahertz imaging systems.

Digital inline pump-probe holography can be applied to estimate parameters of samples' optical nonlinear properties. Here we propose a mathematical model to describe noncollinear degenerate phase modulation in samples with inhomogeneities of nonlinear refractive index over all three dimensions, namely, two-layered samples and samples with local impurities. The impact of sample parameters in the considered configurations is analyzed. We show that analysis of inline digital holograms obtained by time-resolved inline digital holography can be successfully used for rapid detection and characterization of various types of nonlinear refractive index inhomogeneities.

Terahertz phase retrieval is a promising technique able to assess the complex diffracted wave properties through an iterative processing algorithm. In this Letter, we demonstrate the implementation of this technique in reflection geometry with a continuous wave acquisition system working at 0.287 THz. To ensure a high signal-to-noise ratio in the measured dataset, we proposed a double parallel recording scheme with one detector and two lock-in amplifiers operating with the complimentary sensitivity setting. This provided a higher numerical aperture than conventional raster-scanning focal plane imaging. A specialized digital interferometric postprocessing procedure was applied to obtain a surface height map from the reconstructed phase distribution in the object's irradiated area.

Here, we present a comprehensive study of the reconstruction quality in terahertz (THz) pulse time-domain holography. We look into single wavelength reconstructions, as well as broadband recovery enabled by the ultrabroadband nature of radiation and coherent detection enabled by electro-optic or photoconductive sensing. We demonstrate the transverse resolution dependence for amplitude and phase objects on the solid angle of the inline recorded time-domain THz hologram, and then turn to the contrast of reconstructed binary amplitude objects, and further to longitudinal resolution of phase objects. We show that transverse resolution can reach values comparable to the wavelength of the radiation used, and longitudinally, phase objects can be resolved with even greater precision. We compare the obtained resolution with theoretical estimates and show that THz pulse time-domain holography is a powerful non-contact imaging tool.

We investigated the peculiarities of the terahertz pulse time-domain holography principle in the case of raster scanning with the balance detection system. The noise in this system represents a Skellam distribution model, which differentiates it from systems based on a photoconductive antenna. We analyzed this Skellam model and provided both numerical and experimental investigations. We found that the variance of the noise in the balance detection system does not depend on the true signal. Complex-domain images obtained in this model are filtered by block-matching algorithms adapted for spatio-temporal and spatiospectral volumetric data. We presented a new cube complex-domain filter algorithm that uses block matching in all 3D data sets simultaneously in spatial and frequency coordinates. A combination of temporal and complex-domain filters allows us to expand the dynamic range of terahertz frequencies for which we can obtain amplitude/phase information. Experimental data demonstrate an improvement in the quality of the resultant images both in the time domain and complex-spectral domain. The simulation and experimental results are in good agreement.

When calculated in the spectral domain, the propagation of an ultrashort optical pulse may suffer from inaccuracy due to the finite thickness of the object it diffracts on. Unlike monochromatic radiation, ultrashort pulse interaction with an object in the time domain depends on the pulse longitudinal coordinate. Here, we propose an algorithm to study the effect of the object thickness on ultrashort pulse diffraction on amplitude, phase, and three-dimensional highly scattering objects. The algorithm comprises a stepwise approach to simulating the diffraction of ultrashort pulses on apertures or scatterers having a finite thickness. We confirm the applicability of the approach and convergence of the result upon reducing the simulation step. We compare the simulation results obtained with traditionally calculated wavefields and the updated results obtained with the proposed approach. We reveal a discrepancy of about 7% for pulsed radiation with λ =800 n m on a 1 mm thick object. Then, we demonstrate the dependence of this mismatch on the object thickness and show that for non-Gaussian vortex beams, this effect is even more pronounced. We reveal that spatiotemporal coupling effects depend on the pulse-object interaction simulation approach as well. The obtained results demonstrate that applicability of the single-layer representation of the simulated object strongly depends on its specific features, and inaccuracy of such an approach strongly depends on individual characteristics of the object.

In this paper, we have applied a recently developed complex-domain hyperspectral denoiser for the object recognition task, which is performed by the correlation analysis of investigated objects' spectra with the fingerprint spectra from the same object. Extensive experiments carried out on noisy data from digital hyperspectral holography demonstrate a significant enhancement of the recognition accuracy of signals masked by noise, when the advanced noise suppression is applied.

We investigated data denoising in hyperspectral terahertz pulse time-domain holography. Using the block-matching algorithms adapted for spatio-temporal and spatio-spectral volumetric data we studied and optimized parameters of these algorithms to improve phase image reconstruction quality. We propose a sequential application of the two algorithms oriented on work in temporal and spectral domains. Experimental data demonstrate the improvement in the quality of the resultant time-domain images as well as phase images and object's relief. The simulation results are proved by comparison with the experimental ones.

A comprehensive characterization of the diffraction properties of terahertz (THz) pulsed broadband vortex beams consisting of several electromagnetic field oscillations requires state-of-the-art techniques for studying the evolution of a wavefront as it propagates. For this purpose, we have applied the capabilities offered by THz pulse time domain holography. Accurate metrological study of pulsed single-period THz field propagation allowed us to reveal the spatio-temporal and spatiospectral couplings in broadband uniformly topologically charged vortex beams. Here, we reveal dynamics of such beam propagation in a free space as well as in the experiment with edge diffraction with 50% blocking of the beam focal waist. In this study, we compare the dynamics of freely propagating and edge-diffracted THz vortex. Despite the fact that in the amplitude representation one can observe the emergence of strong asymmetry, analysis of the spectral trajectory of the singular point at some distance from the obstacle and the visualization of phase distribution for individual spectral components testify to the conservation of transverse energy circulation. Similar to the edge diffraction of monochromatic optical vortices, it can be interpreted as self-reconstruction of vortex properties. The given term has not previously been used for the case of pulsed broadband THz beams, to the best of our knowledge.

In this paper, we present a novel numerical approach for increasing the resolution of retrieved images of objects after their diffraction patterns are recorded via terahertz pulse time-domain holography (THz PTDH). THz PTDH allows for spectrally resolved imaging with high spatial resolution and does not require the fine alignment of complex optics in the THz path. The proposed data post-processing method opens up the possibility to reconstruct holograms recorded with spatially restricted THz detectors, and overcome the diffraction limit even for the lower-frequency spectral components. The method involves an iterative procedure of backward-forward wavefront propagation to simulate the field distribution beyond the initially recorded hologram area. We show significant improvement in both the object reconstruction and contrast across the whole spectrum, with qualitative resolution enhancement at lower frequency spectral components.

Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia accompanied by the disruption of carbohydrate, lipid, and proteins metabolism and development of long-term microvascular, macrovascular, and neuropathic changes. This review presents the results of spectroscopic studies on the glycation of tissues and cell proteins in organisms with naturally developing and model diabetes and in vitro glycated samples in a wide range of electromagnetic waves, from visible light to terahertz radiation. Experiments on the refractometric measurements of glycated and oxygenated hemoglobin in broad wavelength and temperature ranges using digital holographic microscopy and diffraction tomography are discussed, as well as possible application of these methods in the diabetes diagnostics. It is shown that the development and implementation of multimodal approaches based on a combination of phase diagnostics with other methods is another promising direction in the diabetes diagnostics. The possibilities of using optical clearing agents for monitoring the diffusion of substances in the glycated tissues and blood flow dynamics in the pancreas of animals with induced diabetes have also been analyzed.

The paper is devoted to a computational super-resolution microscopy. A complex-valued wavefront of a transparent biological cellular specimen is restored from multiple intensity diffraction patterns registered with noise. For this problem, the recently developed lensless super-resolution phase retrieval algorithm [Optica, 4(7), 786 (2017)] is modified and tuned. This algorithm is based on a random phase coding of the wavefront and on a sparse complex-domain approximation of the specimen. It is demonstrated in experiments, that the reliable phase and amplitude imaging of the specimen is achieved for the low signal-to-noise ratio provided a low dynamic range of observations. The filterings in the observation domain and specimen variables are specific features of the applied algorithm. If these filterings are omitted the algorithm becomes a super-resolution version of the standard iterative phase retrieval algorithms. In comparison with this simplified algorithm with no filterings, our algorithm shows a valuable improvement in imaging with much smaller number of observations and shorter exposure time. In this way, presented algorithm demonstrates ability to work in a low radiation photon-limited mode., Competing Interests: The authors declare that there are no conflicts of interest related to this article.

Recent works demonstrated that digital time-resolved holography is the prospective approach to study nonlinear light-matter interaction processes. In this Letter, we present a straightforward inline holographic approach for studying degenerate phase modulation induced by an inclined collimated pump beam in the isotropic sample. The method is based on a minimization of the difference between experimentally acquired data and simulated inline holograms obtained from a numerical model of pump-probe interaction in optical nonlinear media. A sophisticated experimental data processing algorithm is implemented to provide high sensitivity and a signal-to-noise ratio eligible for soft interaction with a collimated pump beam. The integral phase shift determined by our method can be used to estimate the nonlinear refractive index and the relaxation time for material with a low damage threshold. We validated our approach for the case of soda-lime and BK7 glasses.

Terahertz pulse time-domain holography is the ultimate technique allowing the evaluating a propagation of pulse broadband terahertz wavefronts and analyze their spatial, temporal and spectral evolution. We have numerically analyzed pulsed broadband terahertz Gauss-Bessel beam's both spatio-temporal and spatio-spectral evolution in the non-paraxial approach. We have characterized two-dimensional spatio-temporal beam behavior and demonstrated all stages of pulse reshaping during the propagation, including X-shape pulse forming. The reshaping is also illustrated by the energy transfer dynamics, where the pulse energy flows from leading edge to trailing edge. This behavior illustrates strong spatio-temporal coupling effect when spatio-temporal distribution of Bessel beam's wavefront depends on propagation distance. The spatio-temporal and spatio-spectral profiles for different spectral components clearly illustrate the model where the Bessel beam's wavefront at the exit from the axicon can be divided into radial segments for which the wave vectors intersect. Phase velocity via propagation distance is estimated and compared with existing experimantal results. Results of the phase velocity calculation depend strongly on distance increment value, thus demonstrating superluminal or subluminal behavior.

We propose a new express method of the correlation characterization of the particles suspended in the volume of optically transparent medium. It utilizes inline digital holography technique for obtaining two images of the adjacent layers from the investigated volume with subsequent matching of the cross-correlation function peak-to-basement ratio calculated for these images. After preliminary calibration via numerical simulation, the proposed method allows one to quickly distinguish parameters of the particle distribution and evaluate their concentration. The experimental verification was carried out for the two types of physical suspensions. Our method can be applied in environmental and biological research, which includes analyzing tools in flow cytometry devices, express characterization of particles and biological cells in air and water media, and various technical tasks, e.g. the study of scattering objects or rapid determination of cutting tool conditions in mechanisms.

A methodology providing noninvasive monitoring and evaluation of the effect of photodynamic treatment on live cells in vitro is presented. Variations in morphological characteristics of cells in the course and after treatment are recorded by means of digital holographic microscopy. High-precision measurements of phase shift gained by probe radiation in HeLa and human endometrial mesenchymal stem cell cultures demonstrate for the first time changes of their volume occurred in response to treatment.

A variational algorithm to object wavefront reconstruction from noisy intensity observations is developed for the off-axis holography scenario with imaging in the acquisition plane. The algorithm is based on the local least square technique proposed in paper [J. Opt. Soc. Am. A21, 367 (2004)]. First, multiple reconstructions of the wavefront are produced for various size and various directional windows applied for localization of estimation. At the second stage, a special statistical rule is applied in order to select the best window size estimate for each pixel of the image and for each of the directional windows. At the third final stage the estimates of the different directions obtained for each pixel are aggregated in the final one. Simulation experiments and real data processing prove that the developed algorithm demonstrate the performance of the extraordinary quality and accuracy for both the phase and amplitude of the object wavefront.

This paper explores the concept of image-plane holographic tomography applied to the measurements of laser-induced thermal gradients in an aqueous solution of a photosensitizer with respect to the reconstruction accuracy of three-dimensional variations of the refractive index. It uses the least-squares estimation algorithm to reconstruct refractive index variations in each holographic projection. Along with the bitelecentric optical system, transferring focused projection to the sensor plane, it facilitates the elimination of diffraction artifacts and noise suppression. This work estimates the influence of typical random and systematic errors in experiments and concludes that random errors such as accidental measurement errors or noise presence can be significantly suppressed by increasing the number of recorded digital holograms. On the contrary, even comparatively small systematic errors such as a displacement of the rotation axis projection in the course of a reconstruction procedure can significantly distort the results.

This work presents the new method for wavefront reconstruction from a digital hologram recorded in off-axis configuration. The main feature of the proposed algorithm is a good ability for noise filtration due to the original formulation of the problem taking into account the presence of noise in the recorded intensity distribution and the sparse phase and amplitude reconstruction approach with the data-adaptive block-matching 3D technique. Basically, the sparsity assumes that low dimensional models can be used for phase and amplitude approximations. This low dimensionality enables strong suppression of noisy components and accurate revealing of the main features of the signals of interest. The principal point is that dictionaries of these sparse models are not known in advance and reconstructed from given noisy observations in a multiobjective optimization procedure. We show experimental results demonstrating the effectiveness of our approach.

The paper presents a novel algorithm based on digital holographic interferometry and being promising for evaluation of phase variations from highly noisy or modulated by speckle-structures digital holograms. The suggested algorithm simulates an interferogram in finite width fringes, by analogy with classical double exposure holographic interferometry. Thus obtained interferogram is then processed as a digital hologram. The advantages of the suggested approach are demonstrated in numerical experiments on calculations of differences in phase distributions of wave fronts modulated by speckle structure, as well as in a physical experiment on the analysis of laser-induced heating dynamics of an aqueous solution of a photosensitizer. It is shown that owing to the inherent capability of the approach to perform adjustable smoothing of compared wave fronts, the resulting difference undergoes noise filtering. This capability of adjustable smoothing may be used to minimize losses in spatial resolution. Since the method allows to vary an observation angle of compared wave fields, an opportunity to compensate misalignment of optical axes of these wave fronts arises. This feature can be required, for example, when using two different setups in comparative digital holography or for compensation of recording system displacements during a set of exposures in studies of dynamic processes.

Surgical treatment of stenosis of the left main coronary artery (LMCA) is a special problem, a number of questions of surgical strategy for this lesion still remain unsolved. The question of direct plasty dilatation of LMCA has not lost its actuality. Operations were made on 6 patients in whom direct plasty dilatation of LMCA with a flap from autopericardium was performed for local, not lengthy constriction which was located in the initial and middle part of LMCA. The operations were made under conditions of extracorporeal circulation, moderate general hypothermia (about 32 degrees C), pharmacohypothermic cardioplagia with external cooling of the heart. In all cases there was good restoration of cardiac activity and the absence of myocardium ischemia at the postoperative period. The restoration of the anatomical lumen of LMCA by this method facilitated sufficient blood flow along LMCA. Five years later all the patients are alive, one patient has external angina of the 11 functional class.

Morphometric analysis of changes in nucleolar organizer (NO), Balbiani rings (BR)--BR(B), BR(1G), BR(2G) and chromosome I arm B puff activities, and in chromosome compactness of Chironomus plumosus (Diptera) polytene chromosomes was carried out in acute period under separate and combined influence of atropine and pilocarpine. Supression effect of cholinotropic preparations mixture was revealed. Suppression of NO activity with atropine concentration increase in the mixture served as criterion of toxicity.

Integrated study of the genetic structure of the Udmurt population with respect to different genetic systems has been performed. Data on the genes of genetic diseases, abiotic parameters analyzed by population statistic methods, and DNA polymorphism are summarized. The populations of six raions (districts) of Udmurt Republic (the Mozhga, Malaya Purga, Sharkan, Debesy, Igra, and Glazov raions) have been studied. The total population studied was 267,655 people (an urban population of 150,119 people and a rural population of 117,536 people), including 155,346 Udmurts. The population structure has been studied in six districts on the basis of the vital statistics, Crow's indices, Malecot's isolation by distance parameters, ethnically assortative marriage parameters, endogamy indices, inbreeding-endogamy (ie) indices, and frequencies of the genotype and allele frequencies of four DNA markers (17 alleles). The prevalences of hereditary diseases have been calculated for different population groups: urban and rural populations, Udmurts and other ethnic groups. These groups, especially the urban and rural populations, substantially differed from one another in the prevalences of autosomal dominant (AR) and autosomal recessive (AR) diseases. The correlation between the prevalence of AD and AR diseases and the ie index is positive and significant. The spectrum of hereditary diseases detected in six districts of Udmurtia comprises 149 diseases (80, 57, and 12 AD, AR, and X-linked diseases, respectively). Accumulation of individual diseases in districts of Udmurtia and accumulation of diseases in Udmurtia as compared to regions studied earlier has been found. Cluster analysis of the frequencies of genes of AD and AR diseases and DNA markers has determined the gene geographic position of Udmurts.

The authors have analyzed their experiences with treatment of 50 patients with ischemic heart disease using transplantation of autologous mono-nuclears of the bone marrow. It was shown that this operation resulted in an improvement of indices of the heart functions and myocardium metabolism. Transplantation of stem cells as mononuclear fraction of the bone marrow is indicated in treatment of different groups of patients: in recurrent diseases after previous operations on the coronary arteries; in patients with distal lesions of the coronary bed; transplantation of autologous stem cells of the bone marrow is expedient simultaneously with coronary artery bypass grafting or coronary angioplasty (stenting).

On the basis of experience in the treatment of 51 patients with infected false joints of the tibia the authors conclude that local circulatory disorders play the decisive role in the genesis of nonunion of the fracture. The recommended methods for removal of the soft tissue defect by various types of pedicled skin grafts in combination with fixation of the fragments and plastic repair, in some cases, of the false joint zone with demineralized bone allografts made it possible to remove the inflammatory process radically and achieve consolidation in 94% of patients who were operated on.

It was shown on identified neurons of freshwater mollusk Lymnaea stagnalis that depending on the concentration haloperidol enhanced chlorine-induced depolarizing effect of carbacholine. A shift of the concentration-effect curve for carbacholine against the background of the neuroleptic action to the left on the axis of abscissae with the preservation of its maximum indicates the allosteric interaction of haloperidol with that part of the choline receptor structure which is territorially isolated from its recognizing centre.