1. CD4 and CD8 T cells infiltration of the polyp tissue in a series of Greek patients with chronic rhinosinusitis with nasal polyps
- Author
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Spyridon Gougousis, Kalliopi Domvri, Konstantinos Porpodis, Ioanna Besli, Petros Karkos, Harissios Vliagoftis, and Ioannis Constantinidis
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Medicine - Abstract
Chronic rhinosinusitis (CRS) presents with two basic phenotypes, CRS with (CRSwNP) or without nasal polyps (CRSsNP). The present study’s objective was to evaluate the clinical characteristics in a Greek population of CRSwNP patients and their relation to the frequency of CD4 + and CD8 + T cells as well as the CD4 + /CD8 + ratio as prognostic biomarkers. Thirty-three adult CRSwNP patients were recruited at the ENT Department of “G. Papanikolaou” General Hospital of Thessaloniki. Tissue samples from nasal polyps were collected during functional endoscopic sinus surgery. Hadley’s nasal endoscopy scores, preoperative Lund-Mackay CT scores, and 22-item Sinonasal Outcome Test, were recorded for each patient. The presence of CD4 + and CD8 + lymphocytes was evaluated in tissue sections by immunohistochemistry. Blood eosinophil and neutrophil counts were also included in the analysis. All data were analyzed with SPSS (version 21.0). Twenty-one males and 12 females were included in the analysis with mean age of 49.5 ± 14.5. LMS ( P 5%, LMS and SNOT 22 were negatively correlated to CD4 + cells ( P = 0.029 r = −0.654, P = 0.043, r = −0.618, respectively). In CRSwNP patients with CD4 + /CD8 + ratio
- Published
- 2021
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