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3. Risk Factors and Options to Improve Engraftment in Unrelated Cord Blood Transplantation

Author

Petropoulou, Anna D. and Rocha, Vanderson

Subjects
fluids and secretions, Article Subject, embryonic structures
Abstract

Use of umbilical unrelated cord-blood (UCB) cells as an alternative source of hematopoietic cell transplantation has been widely used mainly for patients lacking an HLA-matched donor. UCB present many advantages over bone marrow or mobilized peripheral blood from volunteer donors, such as rapid availability, absence of risk for the donor, and decreased incidence of acute graft-versus-host disease. However, a significant clinical problem is delayed engraftment that is directly correlated with the number of hematopoietic stem cells in a cord-blood unit. The identification of prognostic factors associated with engraftment that can be easily modified (e.g., strategies for donor choice) and the development of new approaches including use of multiple donors, intrabone injection of UCB, ex vivo expansion, and cotransplantation with accessory cells are of crucial importance in order to circumvent the problem of delayed engraftment after UCB transplantation. Those approaches may increase the quality and availability of UCB for transplantation.

Published
2011
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5. Increased Infection Rate After Preemptive Rituximab Treatment for Epstein-Barr Virus Reactivation After Allogeneic Hematopoietic Stem-Cell Transplantation

Author

Petropoulou, Anna D., primary, Porcher, Raphael, additional, de Latour, Regis Peffault, additional, Xhaard, Alienor, additional, Weisdorf, Daniel, additional, Ribaud, Patricia, additional, Rodriguez-Otero, Paula, additional, Agbalika, Félix, additional, Talbot, Alexis, additional, Toubert, Antoine, additional, Moins-Teisserenc, Hélène, additional, Carmagnat, Maryvonnick, additional, Socié, Gerard, additional, and Robin, Marie, additional

Published
2012
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6. Female Genital Chronic Graft-Versus-Host Disease

Author

Hirsch, Pierre, primary, Leclerc, Mathieu, additional, Rybojad, Michel, additional, Petropoulou, Anna D., additional, Robin, Marie, additional, Ribaud, Patricia, additional, de la Tour, Régis Peffault, additional, Cavelier-Balloy, Bénédicte, additional, Socié, Gérard, additional, and Vexiau-Robert, Dominique, additional

Published
2012
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7. Endothelial Progenitor Cells in Paroxysmal Nocturnal Hemoglobinuria

Author

Gandrille, Sophie, primary, de Latour, Régis Peffault, additional, Levionnois, Emeline, additional, Petropoulou, Anna D., additional, Galy-Fauroux, Isabelle, additional, Rodriguez-Otero, Paula, additional, Socié, Gérard, additional, Fischer, Anne-Marie, additional, and Helley, Dominique, additional

Published
2011
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8. Long-Term Follow-up of Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Severe Alpastic Anemia After Cyclophosphamide Plus Antithymocyte Globulin Conditioning Regimen,

Author

Konopacki, Johanna, primary, Porcher, Raphael, additional, Robin, Marie, additional, Bieri, Sabine, additional, Cayuela, Jean Michel, additional, Larghero, Jérome, additional, Xhaard, Alienor, additional, Andreoli, Anna-Lisa, additional, Dhedin, Nathalie, additional, Petropoulou, Anna D., additional, Rodriguez-Otero, Paula, additional, Ribaud, Patricia, additional, Moins, Helene, additional, Carmagnat, Mariyvonnick, additional, Toubert, Antoine, additional, Chalandon, Yves, additional, Socié, Gérard, additional, and de Latour, Régis Peffault, additional

Published
2011
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9. Major Improvement of Invasive Aspergillosis Outcome Is Not Enough to Improve Overall Survival In Allogeneic Hematopoietic Stem Cell Transplant Recipients: Results From a Single-Center Retrospective Analysis

Author

Salmeron, Géraldine, primary, Porcher, Raphaël, additional, Bergeron, Anne, additional, Robin, Marie, additional, de Latour, Regis Peffault, additional, Rocha, Vanderson, additional, Petropoulou, Anna D., additional, Xhaard, Alienor, additional, Sulahian, Annie, additional, Socié, Gérard, additional, and Ribaud, Patricia, additional

Published
2010
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11. Second-Line Treatment In Steroid Refractory Acute Graft Versus Host Disease During a 10-Year Period: A Single Centre Experience Comparing 4 Strategies

Author

Xhaard, Alienor, primary, Porcher, Raphael, additional, Rocha, Vanderson, additional, Latour, Regis Peffault de, additional, Bueno, Benjamin, additional, Lenglet, Julien, additional, Petropoulou, Anna D., additional, Ribaud, Patricia, additional, Socié, Gérard, additional, and Robin, Marie, additional

Published
2010
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16. Prospective Assessment of Bone Turnover and Clinical Bone Diseases After Allogeneic Hematopoietic Stem-Cell Transplantation

Author

Petropoulou, Anna D., primary, Porcher, Raphael, additional, Herr, Andrée-Laure, additional, Devergie, Agnès, additional, Brentano, Thomas Funck, additional, Ribaud, Patricia, additional, Pinto, Fernando O., additional, Rocha, Vanderson, additional, Peffault de Latour, Régis, additional, Orcel, Philippe, additional, Socié, Gérard, additional, and Robin, Marie, additional

Published
2010
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25. In VitroEffect of Danaparoid Sodium (Orgaran®) on Thrombin Generation after Minimal Tissue Factor Pathway Activation.

Author

Elalamy, Ismail, Petropoulou, Anna D., Hatmi, Mohamed, Samama, Meyer M., and Gerotziafas, Grigoris T.

Abstract

Introduction: Orgaran® (Org 10172) is a low molecular weight heparinoid which consists of natural sulphated glycosaminoglycans (heparan, dermatan, chondroitin sulphate). It has a mean molecular weight of approximately 6 kDa (4–10 kDa), an excellent bioavailability following subcutaneous administration and an anti-Xa/anti-IIa activity ratio superior to 22. It is the anticoagulant of choice in patients developping Heparin-Induced Thrombocytopenia (HIT), whereas its' use is also proposed for surgical thromboprophylaxis. Orgaran® has no effect on routine coagulation tests (aPTT, PT, TT). Thrombin generation test(TG) is a global clotting assay proven to be sensitive to the anticoagulant effect of LMWHs and specific FXa inhibitors (i.e. fondaparinux and BAY-597939). In this in vitrostudy, we determined the tissue factor (TF)-induced TG inhibition potency of Orgaran® using the Thrombogram-Thrombinoscope® assay.

Published
2005
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26. Inhibition of In VitroThrombin Generation: Another Parameter Reinforcing the LMWH Heterogeneity.

Author

Gerotziafas, Grigoris T., Petropoulou, Anna D., Hatmi, Mohamed, Samama, Meyer M., and Elalamy, Ismail

Abstract

Introduction: Low molecular weight heparins (LMWH) are derived from unfractioned heparin (UFH) by depolymerization. Thus, they present biochemical and pharmacological differences and the ratio of anti-Xa/anti-IIa activities varies from one product to another. In this study, we compared in vitrothe Thrombin Generation (TG) inhibition potency of various LMWHs and UFH using the Thrombogram-Thrombinoscope® assay.

Published
2005
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