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Osteoporosis is a chronic disease that affects millions of patients worldwide and is characterized by low bone mineral density (BMD) and increased risk of fractures. Notably, natural molecules can increase BMD and exert pro-osteogenic effects. Noteworthily, the nutraceutical BlastiMin Complex® (Mivell, Italy, European Patent Application EP4205733A1) can induce differentiation of human bone marrow mesenchymal stem cells (BM-MSCs) in osteoblasts and can exert in vitro pro-osteogenic and anti-inflammatory effects. Thus, the purpose of this study was to verify the effects of BlastiMin Complex® on bone turnover markers (BTMs) and BMD in patients with senile and postmenopausal osteopenia or osteoporosis. The efficacy of BlastiMin Complex® on BTMs in serum was evaluated through biochemical assays. BMD values were analyzed by dual-energy X-ray absorptiometry (DXA) and Radiofrequency Echographic Multi Spectrometry (R.E.M.S.) techniques, and the SNPs with a role in osteoporosis development were evaluated by PCR. Clinical data obtained after 12 months of treatment showed an increase in bone turnover index, a decrease in C-reactive protein levels, and a remarkable increase in P1NP levels, indicating the induction of osteoblast proliferation and activity in the cohort of 100% female patients recruited for the study. These findings show that the nutraceutical BlastiMin Complex® could be used as an adjuvant in combination with synthetic drugs for the treatment of osteoporosis pathology. [ABSTRACT FROM AUTHOR]

Space, intended as an anthropological locus can become a decoder of cultural complexity. It represents a vision, a certain way of looking that, in this case, has been adopted to understand those parts of the social fabric that dwell the places of the city of Rome re-inventing and re-contextualizing them culturally. Places where the social actors are the Nigerians residing in Rome. This essay wants to examine the bases on which the cultural diversity of the Nigerians is generated; the realities that generate these places in the territory of Rome and their meaning for the Nigerian immigrants; the change of perception in our way of living and dwelling in the places generated by our culture that inevitably coexist with those of the Nigerians. All this starting from a perspective that has oriented the research on the Nigerian community in Rome: that of the networks. [ABSTRACT FROM AUTHOR]