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2. Reduced Paneth cell alpha-defensins in ileal Crohn's disease

Author

Wehkamp, J, Salzman, N H, Porter, E, Nuding, S, Weichenthal, M, Petras, R E, Shen, B, Schaeffeler, E, Schwab, M, Linzmeier, R, Feathers, R W, Chu, H T, Lima, H, Fellermann, K, Ganz, T, Stange, E F, and Bevins, Charles L

Subjects
innate immunity, intestine, bacteria, inflammatory bowel disease
Abstract

The pathogenesis of Crohn's disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal inflammation in genetically susceptible individuals. Paneth cells (PC) are the major source of antimicrobial peptides in the small intestine, including human alpha-defensins HD5 and HD6. We tested the hypothesis that reduced expression of PC alpha-defensins compromises mucosal host defenses and predisposes patients to CD of the ileum. We report that patients with CID of the ileum have reduced antibacterial activity in their intestinal mucosal extracts. These specimens also showed decreased expression of PC alpha-defensins, whereas the expression of eight other PC products either remained unchanged or increased when compared with controls. The specific decrease of alpha-defensins was independent of the degree of inflammation in the specimens and was not observed in either CD of the colon, ulcerative colitis, or pouchitis. The functional consequence of alpha-defensin expression levels was examined by using a transgenic mouse model, where we found changes in HD5 expression levels, comparable to those observed in CD, had a pronounced impact on the luminal microbiota. Thus, the specific deficiency of PC defensins that characterizes ileal CD may compromise innate immune defenses of the ileal mucosa and initiate and/or perpetuate this disease.

Published
2005

9. Contributors

Author

Akoh, Casimir C., primary, Amadou, Issoufou, additional, Annegowda, Hardur Venkatappa, additional, Bassi, Daniele, additional, Bhat, Rajeev, additional, Bobinaitė, Ramunė, additional, Casierra-Posada, Fánor, additional, Česonienė, Laima, additional, Chacrabati, Rakhi, additional, Chen, Kunsong, additional, Chidley, Hemangi, additional, Cota-Sánchez, J. Hugo, additional, Cuellar, Fabio, additional, Dar, M. Saleem, additional, Daubaras, Remigijus, additional, de Guía Córdoba, María, additional, Denaxa, Nikoleta-Kleio, additional, Deshpande, Ashish, additional, Djordjević, Boban, additional, Efstathios, Ntanos, additional, Egydio Brandão, Anary P.M., additional, Fabroni, Simona, additional, Fortes, Ana M., additional, Gao, Wenyuan, additional, Giri, Ashok, additional, Goswami, Chayon, additional, Gündüz, Kazim, additional, Gupta, Vidya, additional, Henare, Sharon J., additional, Hernández, Alejandro, additional, Howes, Melanie-Jayne R., additional, Intidhar, Bouali, additional, Jaakola, Laura, additional, Jarma-Orozco, Alfredo, additional, Klemettilä, Hannele, additional, Lado, Joanna, additional, Li, Xian, additional, Li, Xia, additional, Li, Xuejiao, additional, López-Corrales, Margarita, additional, Marie-Alphonsine, Paul–Alex, additional, Martín, Alberto, additional, Mignani, Ilaria, additional, Mikulic-Petkovsek, Maja, additional, Oak, Pranjali, additional, Pais, Maria S., additional, Pande, Garima, additional, Pareek, Sunil, additional, Pljevljakušić, Dejan, additional, Rapisarda, Paolo, additional, Rodrigo, María Jesús, additional, Rodríguez Medina, Narciso Nerdo, additional, Romeo, Flora Valeria, additional, Roussos, Peter A., additional, Ruiz-Moyano, Santiago, additional, Santos, Déborah Yara A.C., additional, Šavikin, Katarina, additional, Serradilla, Manuel Joaquín, additional, Simmonds, Monique S.J., additional, Soler, Alain, additional, Spinardi, Anna, additional, Sun, Guang-Ming, additional, Tsafouros, Athanasios, additional, Tura, Debora, additional, Valdés-Infante Herrero, Juliette, additional, Veberic, Robert, additional, Venskutonis, Petras R., additional, Viškelis, Pranas, additional, Wang, Tingting, additional, Xu, Changjie, additional, Zacarías, Lorenzo, additional, Zdunić, Gordana, additional, Zhang, Xiu-Mei, additional, and Zoratti, Laura, additional

Published
2016
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16. 93rd annual convention podium and poster abstracts

Author

Davis, C. M., Strong, S. A., Hellinger, M. D., Williamson, P. R., Larach, S. W., Ferrara, A., Blake, T. B., Medich, D. S., Ziv, Y., Oakley, J. R., Reissman, P., Piccirillo, M., Ulrich, A., Nogueras, J. J., Wexner, S. D., Rubin, M. S., Bodenstein, L. E., Kent, K. C., Williamson, M. E. R., Lewis, W. G., Sagar, P. M., Holdsworth, P. J., Johnston, D., Fazio, V. W., Goldblum, J. R., Sirimarco, M. T., Lavery, I. C., Petras, R. E., Treem, W. R., Cohen, J., Davis, P. M., Hyams, J. S., Eu, K. W., Bartolo, D. C. C., Green, J. D., Riether, R. D., Rosen, L., Stasik, J. J., Sheets, J. A., Reed, J., Khubchandani, I. T., Armitage, N. C., Chapman, M., Hardcastle, J. D., Viamonte, M., Plasencia, G., Wiltz, O., Jacobs, M., Finan, P. J., Passaro, M., Church, J. M., McGannon, E., Wilson, M., Hull-Boiner, S., Kollmorgen, C. F., Meagher, A. P., Wolff, B. G., Pemberton, J. H., Martenson, J. A., Ilstrup, D. M., Moran, M. R., Ramos, A., Rothenberger, D. A., Goldberg, S. M., Johnson, D., Madoff, R. D., Wong, W. D., Finne, III, C. O., Konishi, F., Furuta, K., Kanazawa, K., Lockhart, D., Schmitt, S., Caushaj, P. P., Garcia-Aguilar, J., Belmonte, C., Schiesel, E. C., Mazier, W. P., Senagore, A. J., Piccirillo, M. F., Teoh, T. -A., Yoon, K. -S., Paul, R. A. Patino, Lucas, J., Nelson, R., Norton, N., Cautley, E., Schouten, W. R., Briel, J. W., Auwerda, J. J. A., de Graaf, E. J. R., Lowry, A. C., Sentovich, S. M., Blatchford, G. J., Rivela, L. J., Thorson, A. G., Christensen, M. A., Jorge, J. M. N., Yang, Y. K., Shafik, A., Allendorf, J. D. F., Kayton, M. L., Libutti, S. K., Trokel, M. J., Whelan, R. L., Treat, M. R., Nowygrod, R., Bessler, M., Frank, R. E., Saclarides, T. J., Leurgans, S., Speziale, N. J., Drab, E., Rubin, D., Hull, T. L., Schroeder, T. K., Scholefield, J. H., Ogunbiyi, O. A., Smith, J. H. F., Rogers, K., Sharp, F., Longo, W. E., Vernava, III, A. M., Wade, T. P., Coplin, M. A., Virgo, K. S., Johnson, F. E., Brady, M., Kavolius, J., Quan, S. H. Q., Goldstein, E. T., Feldman, S., Shub, H. A., Bennett, D. R., Kumar, R., McMillen, M. A., Thornton, S., Khoury, D. A., Opelka, F. G., Teoh, T -A., Cohen, S. M., Weiss, E. G., Ortiz, H., De Miguel, M., Armendáriz, P., Rodriguez, J., Chocarro, C., Farouk, R., Dorrance, H. R., Duthie, G. S., Rainey, J. B., Morgado, Jr., P. J., Corman, M. L., Kawamura, Y. J., Sawada, T., Muto, T., Nagai, H., Hill, J., MacLennan, I., Binderow, S. R., Daniel, N., Ehrenpreis, E. D., Jensen, J. E., Bonner, G. F., Ruderman, W. B., Milsom, J. W., Gibbs, D. H., Beck, D. E., Hicks, T. C., Timmcke, A. E., Gathright, Jr, J. B., Cheong, D., Lucas, F. V., McGinity, M., Taylor, B. A., Godwin, P., Holdsworth, P., Lewis, W., Quirke, P., Williamson, M., Kokoszka, J., Pavel, D., Abcarian, H., Stephenson, B. M., Morgan, A. R., Salaman, J. R., Wheeler, M. H., Tran, T. C. K., Willemsen, W., Kuijpers, H. C., Lehman, J. F., Wiseman, J. S., MacFie, J., Sedman, P., May, J., Mancey-Jones, B., Johnstone, D., Nwariaku, F. E., Rochon, R. B., Huber, P. J., Carrico, C. J., Ortega, A., Beart, R., Winchester, D., Steele, G., Green, R., Caushaj, P. F., Devereaux, D., Griffey, S., Reiver, D., Kmiot, W. A., Baker, R., Luchtefeld, M. A., Anthone, G., Schlinkert, R., Roig, J. V., Villoslada, C., Solana, A., Alos, R., Hinojosa, J., Lledo, S., Johnson, D. R. E., Buie, W. D., Jensen, L. L., Heine, J., Hoffmann, B., Timmcke, A., Hicks, T., Opelka, F., Beck, D., Sousa, Jr., A., AraÚjo, S. A., Damico, F. M., Cordeiro, A. C., Pinotti, H. W., Gama, A. H., Fengler, S., Pearl, R., Orsay, C., Seow-Choen, F., Ho, J. M. S., Wiltz, O. H., Torregrosa, M., Brasch, R. C., Bufo, A. J., Krienberg, P., Johnson, G. P., Gowen, G. F., Mullen, P. D., Behrens, D., Hughes, T. G., Wynn, M., Pollack, J. S., Rajagopal, A. S., Huynh, T., Schanbacher, C., Hickson, W. G. E., Yang, Y. -K., Heymen, S., Choi, S. -K., Teoh, T. -A., Wexner, S. D., Vaccaro, C. A., Teoh, T. A., Nogueras, J. J., Choi, S. K., Cheong, D. M. O., Salanga, V. D., MacDonald, A., Baxter, J. N., Finlay, I. G., Mellgren, A., Bremmer, S., Dolk, A., Gillgren, P., Johansson, C., Ahlbäck, S. O., Udén, R., Holmström, B., Ferrara, A., O'Donovan, S., Larach, S. W., Williamson, P. R., Neto, J. A. Reis, Ciquini, S., Quilici, F. A., Reis, Jr., J. A., Torrabadella, L., Salgado, G., Whelan, R. L., Horvath, K. D., Golub, R., Ahsan, H., Cirocco, W., Ziv, Y., Fazio, V. W., Oakley, J. R., Church, J. M., Milsom, J. W., Lavery, L. C., Cohen, S. M., Kmiot, W. A., Reiver, D., Reissman, P., Weiss, E. G., Alós, R., García-Granero, E., Roig, J. V., Uribe, N., Sala, C., Lledo, S., Ozuner, G., Strong, S. A., Bufo, A. J., Daniels, G., Lieberman, R. C., Feldman, S., Lucas, F. V., Longo, W. E., Polites, G., Deshpande, Y., Vernava, A. M., Niehoff, M., Chandel, B., Berglund, D. D., Madoff, R. D., Gemlo, B. T., Spencer, M. P., Goldberg, S. M., Lowry, A. C., Marcello, P. W., Roberts, P. L., Schoetz, D. J., Murray, J. J., Coller, J. A., Veidenheimer, M. C., Koltun, W. A., Bloomer, M. M., Colony, P., Ruggeiro, F., Fleshner, P. R., Michelassi, F., Lewis, W., Williamson, M., Holdsworth, P., Finan, P., Ash, D., Johnston, D., Moran, M. R., Ramos, A., Rothenberger, D. A., Antonenko, D. R., Khanduja, K. S., Fitzgerald, S. D., Meagher, A. P., Moniz-Pereira, P., Wolff, B. G., Outwater, E. K., Marks, G. J., Mohiuddin, M., Sagar, P. M., Hartley, M. N., Mancey-Jones, B., Sedman, P., May, J., MacFie, J., Holbrook, R. F., Rodriguez-Bigas, M. A., Ramakrishnan, K., Palmer, M. L., Petrelli, N. J., Takahashi, T., Nivatvongs, S., Batts, K. P., Lucas, S. W., Klein, S. N., Keidan, R. D., Bannon, J. P., Zhou, J., Armitage, N. C., Hunt, L. M., Robinson, M. H., Hugkulstone, C. E., Clarke, B., Vernon, S. A., Gregson, R. H., Hardcastle, J. D., Ryan, M., Dutta, S., Levine, A., Ortega, A., Anthone, G., Beart, R., Dominguez, J. M., Saclarides, T. J., Bolan, P., Bines, S. D., Adachi, M., Watanabe, T., Sawada, T., Okinaga, K., Muto, T., Hase, K., Shatney, C., Mochizuki, H., Johnson, D., Ure, T., Dehghan, K., Andrus, C. A., Daniel, G. L., D'Emilia, J. C., Rodriguez-Bigas, M., Suh, O. K., Brewer, D. A., Fung, C., Chapuis, P., Bokey, E. L., Garcia, J. C., Banerjee, S., Remzi, F. H., Lavery, I. C., Jorge, J. M. N., Ger, G. C., Gonzalez, L., Gee, A. S., Roe, A. M., Durdey, P., Kaye, M. D., Kyzer, S., Gordon, P. H., Hasegawa, M., Bun, P. Tae, Ikeuchi, D., Onodera, H., Imamura, M., Maetani, S., Blake, T., Hellinger, M., Grewal, H., Klimstra, D. S., Cohen, A. M., Guillem, J. G., Rooney, P. S., Gifford, K. -A., Clarke, P. A., Kuhn, J. A., Bryce, K., Frank, N., Dignan, R. D., Lichliter, W. E., Franko, E., Jacobson, R. M., Preskitt, J. T., Lieberman, Z., Tulanon, P., Steinbach, H., McCarty, T., Simons, T., Plasencia, G., Viamonte, M., Wiltz, O., Jacobs, M., Chen, W. S., Leu, S. Y., Hsu, H., Bessler, M., Halverson, A., Kayton, M. L., Treat, M. R., Nowygrod, R., Congilosi, S., Madoff, R., Wong, W. D., Rothenberger, D., Buie, W. D., Paterson, R., Cartmill, J. A., Trokel, M. J., Gingold, B. S., Cooper, M., Gorfine, S. R., Bauer, J. J., Gelernt, I. M., Kreel, I., Harris, M. T., Vallejo, J. F., Kestenberg, A., Miyajima, N., Kano, N., Ishikawa, Y., Sakai, S., Yamakawa, T., Otchy, D. P., Van Heerden, J. A., Ilstrup, D. M., Weaver, A. L., Winter, L. D., Mav, J., Lee, P. Y., Vetto, J. T., Sullivan, E. S., Rabkin, J., Mayoral, J. L., Matas, A. J., Bove, P., Visser, T., Barkel, D., Villalba, M., Bendick, P., Glover, J., Golub, R. W., Cirocco, W. C., Daniel, N., Altringer, W., Domingues, J. M., Brubaker, L. T., Smith, C. S., Kumar, S., and Gilbert, P.

Published
1994
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25. An Integrated Architecture for Cooperation Rovers

Author

Estlin, T, Das, H, Hayati, S, Jain, A, Yen, J, Petras, R, Rabideau, G, Castano, R, Chien, S, Mjolsness, E, Steele, R, Mutz, D, Gray, A, Mann, T, Decoste, D, and Tunstel, E

Published
1999

27. An Integrated Architecture for Cooperation Rovers

Author

Tunstel, E, Decoste, D, Mann, T, Gray, A, Mutz, D, Steele, R, Mjolsness, E, Chien, S, Castano, R, Rabideau, G, Petras, R, Yen, J, Jain, A, Hayati, S, Das, H, and Estlin, T

Abstract

The paper presents a rover execution architecture for controlling multiple, cooperating rovers. The overall goal of this architecture is to coordinate multiple rovers in performing complex tasks for planetary science.

Published
1999

28. Fuzzy Reactive Piloting for Continuous Driving of Long Range Autonomous Planetary Micro-Rovers

Author

Petras, R, Hayati, S, Volpe, R, and Martin-Alvarez, A

Abstract

A complete piloting control subsystem for a highly autonomous long range rover will be defined in order to identify the key control functions needed to achieve continuous driving that maximizes the range and number of interesting scientific sites visited during the limited life time of a planetary rover.

Published
1999

30. A Prototype Manipulation System for Mars Rover Science Operations

Author

Volpe, R, Ohm, T, Petras, R, Welch, R, and Ivlev, R

Subjects
Lunar And Planetary Science And Exploration
Abstract

This paper provides an overview of a new manipulation system developed for sampling and instrument placement from small autonomous mobile robots for Mars exploration. Selected out of the design space, two manipulators have been constructed and integrated into the Rocky 7 Mars rover prototype. This paper describes objectives and constraints for these manipulators, and presents the finished system and some results from its operation.

Published
1997

31. The Rocky 7 Rover: A Mars Sciencecraft Prototype

Author

Hayati, S, Volpe, R, Backes, P, Balaram, J, Welch, R, Ivlev, R, Tharp, G, Peters, S, Ohm, T, Petras, R, and Laubach, S

Subjects
Lunar And Planetary Science And Exploration
Abstract

This paper describes the design and implementation of a small rover for future Mars missions requiring long traverses and rover-based science experiments at the Jet Propulsion Laboratory.

Published
1997

32. Contributors

Author

Casimir C. Akoh, Issoufou Amadou, Hardur Venkatappa Annegowda, Daniele Bassi, Rajeev Bhat, Ramunė Bobinaitė, Fánor Casierra-Posada, Laima Česonienė, Rakhi Chacrabati, Kunsong Chen, Hemangi Chidley, J. Hugo Cota-Sánchez, Fabio Cuellar, M. Saleem Dar, Remigijus Daubaras, María de Guía Córdoba, Nikoleta-Kleio Denaxa, Ashish Deshpande, Boban Djordjević, Ntanos Efstathios, Anary P.M. Egydio Brandão, Simona Fabroni, Ana M. Fortes, Wenyuan Gao, Ashok Giri, Chayon Goswami, Kazim Gündüz, Vidya Gupta, Sharon J. Henare, Alejandro Hernández, Melanie-Jayne R. Howes, Bouali Intidhar, Laura Jaakola, Alfredo Jarma-Orozco, Hannele Klemettilä, Joanna Lado, Xian Li, Xia Li, Xuejiao Li, Margarita López-Corrales, Paul–Alex Marie-Alphonsine, Alberto Martín, Ilaria Mignani, Maja Mikulic-Petkovsek, Pranjali Oak, Maria S. Pais, Garima Pande, Sunil Pareek, Dejan Pljevljakušić, Paolo Rapisarda, María Jesús Rodrigo, Narciso Nerdo Rodríguez Medina, Flora Valeria Romeo, Peter A. Roussos, Santiago Ruiz-Moyano, Déborah Yara A.C. Santos, Katarina Šavikin, Manuel Joaquín Serradilla, Monique S.J. Simmonds, Alain Soler, Anna Spinardi, Guang-Ming Sun, Athanasios Tsafouros, Debora Tura, Juliette Valdés-Infante Herrero, Robert Veberic, Petras R. Venskutonis, Pranas Viškelis, Tingting Wang, Changjie Xu, Lorenzo Zacarías, Gordana Zdunić, Xiu-Mei Zhang, and Laura Zoratti

Published
2016

33. Nutritional Components of Amaranth Seeds and Vegetables: A Review on Composition, Properties, and Uses

Author

Petras R, Venskutonis and Paulius, Kraujalis

Abstract

A few decades ago Amaranthus was rediscovered as a most promising plant genus that may provide high-quality protein, unsaturated oil, and various other valuable constituents. Since then research has focused on various Amaranthus spp. and has been rapidly expanding, and a large number of reports have been published. Several review articles focusing on different aspects, such as botanical, agrotechnological, compositional, biological, chemical, and technological properties, as well as applications and health effects, have also been published since then. This comprehensive review is focused on amaranth composition, antioxidant properties, applications, and processing. The composition includes macrocomponets (lipids, proteins, carbohydrates, and dietary fiber) and other important constituents, such as squalene, tocopherols, phenolic compounds, phytates, and vitamins. These aspects of amaranth studies have not been comprehensively reviewed for a long time.

Published
2013

38. Processing of Lovage into High-Value Components Using Supercritical CO2 and Pressurized Liquid Extraction.

Author

Kemzūraitė, Aurelija, Venskutonis, Petras R., and Navikienė, Diana

Subjects
*CARBON dioxide, *ANTIOXIDANTS, *CHEMICAL inhibitors, *METHANOL, *ACETONE
Abstract

Lovage roots, leaves, and stems were extracted by supercritical carbon dioxide (SFE-CO2), while the residues of SFE-CO2 were further extracted by pressurized liquid extraction with acetone and methanol. Optimization of SFE-CO2 parameters resulted in enhanced extract yields from all lovage parts. The antioxidant potential of solid material and extracts was assessed by Trolox-equivalent antioxidant capacity (TEAC) in two different assays and by the total phenolic content (TPC). TEAC and TPC values of SFE-CO2 residues were distinctly lower than those of the initial lovage material which indicates that lovage antioxidants are distributed both in lipophilic and fat-insoluble fractions. [ABSTRACT FROM AUTHOR]

Published
2014
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