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136 results on '"Petrarulo, Michele"'

3. Urine and stone analysis for the investigation of the renal stone former: a consensus conference

Author

Williams, Jr., James C., Gambaro, Giovanni, Rodgers, Allen, Asplin, John, Bonny, Olivier, Costa-Bauzá, Antonia, Ferraro, Pietro Manuel, Fogazzi, Giovanni, Fuster, Daniel G., Goldfarb, David S., Grases, Félix, Heilberg, Ita P., Kok, Dik, Letavernier, Emmanuel, Lippi, Giuseppe, Marangella, Martino, Nouvenne, Antonio, Petrarulo, Michele, Siener, Roswitha, Tiselius, Hans-Göran, Traxer, Olivier, Trinchieri, Alberto, Croppi, Emanuele, and Robertson, William G.

Published
2021
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7. Il ruolo del laboratorio clinico nella diagnostica della calcolosi renale.

Author

Petrarulo, Michele, Leporati, Marta, Pullara, Federica, Valesella, Paolo, Busso, Simone, Canevaro, Alessandra, Prestigiovanni, Michael, and Cosseddu, Domenico

Subjects
*KIDNEY stones, *URINARY calculi, *KIDNEY diseases, *MEDICAL technology, *PATHOGENESIS, *HIGH performance liquid chromatography, *HOSPITAL laboratories
Abstract

The pathogenesis of urolithiasis is related to the presence of physico-chemical abnormalities in the urine environment. These anomalies can be highlighted and evaluated through specific biochemical investigations, often not included in the usual activities of a hospital laboratory. The laboratory activities include the adoption of the most appropriate procedures for the evaluation of urine saturation with respect to lithogenic salts (propensity to stone formation), the identification and analysis of precursors and inhibitors of crystallization, the biochemical investigation for the identification of pre-existing diseases, including the genetic ones, and the analysis of kidney stones. Over the years, in the medical approach to nephrolithiasis, the need for specialized analytical techniques has increasingly raised, requiring the use of versatile technology (HPLC, GC-LC/MS, FTIR), adaptable to the investigation of substances belonging to the most varied classes and present in different biological matrices. In this paper we describe the main analytical activities carried out by a specialized laboratory for the study of renal stone disease. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Urine and stone analysis for the investigation of the renal stone former: a consensus conference

Author

Williams, James C., primary, Gambaro, Giovanni, additional, Rodgers, Allen, additional, Asplin, John, additional, Bonny, Olivier, additional, Costa-Bauzá, Antonia, additional, Ferraro, Pietro Manuel, additional, Fogazzi, Giovanni, additional, Fuster, Daniel G., additional, Goldfarb, David S., additional, Grases, Félix, additional, Heilberg, Ita P., additional, Kok, Dik, additional, Letavernier, Emmanuel, additional, Lippi, Giuseppe, additional, Marangella, Martino, additional, Nouvenne, Antonio, additional, Petrarulo, Michele, additional, Siener, Roswitha, additional, Tiselius, Hans-Göran, additional, Traxer, Olivier, additional, Trinchieri, Alberto, additional, Croppi, Emanuele, additional, and Robertson, William G., additional

Published
2020
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24. Updated genetic testing of Italian patients referred with a clinical diagnosis of primary hyperoxaluria

Author

Pelle, Alessandra, primary, Cuccurullo, Alessandra, additional, Mancini, Cecilia, additional, Sebastiano, Regina, additional, Stallone, Giovanni, additional, Negrisolo, Susanna, additional, Benetti, Elisa, additional, Peruzzi, Licia, additional, Petrarulo, Michele, additional, De Marchi, Mario, additional, Marangella, Martino, additional, Amoroso, Antonio, additional, Giachino, Daniela, additional, and Mandrile, Giorgia, additional

Published
2016
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25. Use of drugs for nephrolithiasis

Author

Marangella, Martino, Vitale, Corrado, Bagnis, Cristiana, Petrarulo, Michele, and Tricerri, Alberto

Subjects
Mini-Review, urologic and male genital diseases
Abstract

Renal stone disease often begins by renal colic. In order to manage this event adequately, several goals should be pursued: first, attenuate pain; second, favour progression and spontaneous expulsion of stones; third, prevent from obstructive and infectious complications. All of the aforementioned points pertain to medical management of this disease. Concerning prevention, it is widely agreed that pathogenesis of kidney stones is a consequence of abnormalities in urine environment, leading to a disequilibrium between promoters and inhibitors of crystallization. Therefore, the rationale for therapy is to make urine less conductive to stone formation, by both decreasing state of saturation and increasing inhibitory potential. In only some types of stone-forming salts it is possible to obtain undersaturation with the solid phase. Indeed, uric acid stones can be chemically dissolved by using alkali and allopurinol. To a lesser extent, this also applies to cystine stones, with the use of thiols and alkali. In these subsets, the aforementioned tools are also effective to prevent new stone formation. Much more challenging appears the treatment of calcium containing stones. About 10% of such stones is caused by systemic disorders and, in these cases, the prevention of new stones is successfully accomplished by curing the underlying disease. For instance, parathyroidectomy cures calcium nephrolithiasis in case of hyperparathyroidism. However, the majority of patients with calcium stones are idiopathic stone-formers, in whom metabolic abnormalities often occur, namely, hypercalciuria, hyperoxaluria, hypocitraturia. The correction of these abnormalities by using thiazide diuretics, alkaline citrates, potassium phosphate and bisphosphonates is based on the prevailing metabolic defect. Among the most recent available tools, Oxalobacter Formigenes and probiotics have been proposed to treat primary or secondary hyperoxalurias. In general, the treatment of stone disease reduces its recurrence rate, but only seldom results in stable remission. Anyway, less stones mean reduction of the need for urological procedures and the associated infective or obstructive complications. Of course, medical prevention implies financial efforts, but a careful cost to benefit analysis demonstrates that these are well justified.

Published
2008

26. Suicidal poisoning with barium chloride

Author

Moreno Bertoni, Petrarulo Michele, Stefano Jourdan, Marco Rossi, and Pellegrino Sergio

Subjects
Male, medicine.medical_specialty, Resuscitation, education, Barium Compounds, chemistry.chemical_element, Autopsy, Urine, Drug overdose, Pathology and Forensic Medicine, chemistry.chemical_compound, Chlorides, Cause of Death, medicine, Ingestion, Humans, Emergency team, Coma, business.industry, Depression, digestive, oral, and skin physiology, Barium chloride, Barium, Middle Aged, medicine.disease, digestive system diseases, Surgery, Suicide, chemistry, Anesthesia, Drug Overdose, business, Law
Abstract

A 49-year-old male pharmacist suffering from depression phoned the emergency services telling of how he had ingested barium chloride. He was found semicomatose in bed and resuscitation attempts were to no avail and he died at the scene. A white plastic container labelled "Barium chloride... Poison", and a book with a writing on a blank page... "give sulphate... SO(4)" were found. At autopsy, 1l of whitish-yellow fluid was found in the stomach. Autopsy barium levels were: blood 9.9mg/l; bile 8.8mg/l; urine 6.3mg/l; gastric 10.0g/l. Cause of death was given as cardiorespiratory arrest due to barium chloride poisoning. The issue of barium toxicity in a variety of itatrogenic and non itatrogenic situation is discussed together with the two only other cases of suicidal barium ingestion, and the feasibility of early intervention at the scene by an emergency team.

Published
2001

32. A Simple Quantitative Test for Screening Cystinuria

Author

Guerra, Angela, primary, Petrarulo, Michele, additional, Schianchi, Tania, additional, Allegri, Franca, additional, Meschi, Tiziana, additional, Bruno, Michele, additional, Ramello, Adriano, additional, Baruffaldi, Marisa, additional, Novarini, Almerico, additional, and Borghi, Loris, additional

Published
2002
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