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3. Expanding the roles of community health workers to sustain programmes during malaria elimination: a meeting report on operational research in Southeast Asia

Author

Dysoley, Lek, Callery, James J., Bunreth, Voeurng, Vanna, Moul, Davoeung, Chan, Sovann, Yok, You, Sles, Ol, Sam, Tripura, Rupam, Chew, Rusheng, Chandna, Arjun, Christiansen-Jucht, Céline, Hughes, Jayme, Sokomar, Nguon, Sophornarann, Top, Rideout, Jeanne, Veyvath, Tat, Sarith, Oum, Puthy, Thaung, Sothearoth, Hay, An, Sen Sam, Zaman, Sazid Ibna, von Seidlein, Lorenz, Vanthy, Lim, Sodavuth, Preap, Vannak, Chrun, Dondorp, Arjen M., Lubell, Yoel, Maude, Richard J., Peto, Thomas J., and Adhikari, Bipin

Published
2024
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5. Clustering of malaria in households in the Greater Mekong Subregion: operational implications for reactive case detection

Author

Mukaka, Mavuto, Peerawaranun, Pimnara, Parker, Daniel M, Kajeechiwa, Ladda, Nosten, Francois H, Nguyen, Thuy-Nhien, Hien, Tran Tinh, Tripura, Rupam, Peto, Thomas J, Phommasone, Koukeo, Mayxay, Mayfong, Newton, Paul N, Imwong, Mallika, Day, Nicholas PJ, Dondorp, Arjen M, White, Nicholas J, and von Seidlein, Lorenz

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Vector-Borne Diseases, Rare Diseases, Clinical Research, Infectious Diseases, Malaria, Infection, Good Health and Well Being, Asia, Southeastern, Case Management, Cluster Analysis, Family Characteristics, Prevalence, Microbiology, Public Health and Health Services, Tropical Medicine, Medical microbiology, Public health
Abstract

BackgroundMalaria reactive case detection is the testing and, if positive, treatment of close contacts of index cases. It is included in national malaria control programmes of countries in the Greater Mekong Subregion to accelerate malaria elimination. Yet the value of reactive case detection in the control and elimination of malaria remains controversial because of the low yield, limited evidence for impact, and high demands on resources.MethodsData from the epidemiological assessments of large mass drug administration (MDA) studies in Myanmar, Vietnam, Cambodia and Laos were analysed to explore malaria infection clustering in households. The proportion of malaria positive cases among contacts screened in a hypothetical reactive case detection programme was then determined. The parasite density thresholds for rapid diagnostic test (RDT) detection was assumed to be > 50/µL (50,000/mL), for dried-blood-spot (DBS) based PCR > 5/µL (5000/mL), and for ultrasensitive PCR (uPCR) with a validated limit of detection at 0.0022/µL (22/mL).ResultsAt baseline, before MDA, 1223 Plasmodium infections were detected by uPCR in 693 households. There was clustering of Plasmodium infections. In 637 households with asymptomatic infections 44% (278/637) had more than one member with Plasmodium infections. In the 132 households with symptomatic infections, 65% (86/132) had more than one member with Plasmodium infections. At baseline 4% of households had more than one Plasmodium falciparum infection, but three months after MDA no household had more than one P. falciparum infected member. Reactive case detection using DBS PCR would have detected ten additional cases in six households, and an RDT screen would have detected five additional cases in three households among the 169 households with at least one RDT positive case. This translates to 19 and 9 additional cases identified per 1000 people screened, respectively. Overall, assuming all febrile RDT positive patients would seek treatment and provoke reactive case detection using RDTs, then 1047 of 1052 (99.5%) Plasmodium infections in these communities would have remained undetected.ConclusionReactive case detection in the Greater Mekong subregion is predicted to have a negligible impact on the malaria burden, but it has substantial costs in terms of human and financial resources.

Published
2021

6. Mass drug administrations with dihydroartemisinin-piperaquine and single low dose primaquine to eliminate Plasmodium falciparum have only a transient impact on Plasmodium vivax: Findings from randomised controlled trials

Author

Phommasone, Koukeo, van Leth, Frank, Peto, Thomas J, Landier, Jordi, Nguyen, Thuy-Nhien, Tripura, Rupam, Pongvongsa, Tiengkham, Lwin, Khin Maung, Kajeechiwa, Ladda, Thwin, May Myo, Parker, Daniel M, Wiladphaingern, Jacher, Nosten, Suphak, Proux, Stephane, Nguon, Chea, Davoeung, Chan, Rekol, Huy, Adhikari, Bipin, Promnarate, Cholrawee, Chotivanich, Kesinee, Hanboonkunupakarn, Borimas, Jittmala, Podjanee, Cheah, Phaik Yeong, Dhorda, Mehul, Imwong, Mallika, Mukaka, Mavuto, Peerawaranun, Pimnara, Pukrittayakamee, Sasithon, Newton, Paul N, Thwaites, Guy E, Day, Nicholas PJ, Mayxay, Mayfong, Hien, Tran Tinh, Nosten, Francois H, Cobelens, Frank, Dondorp, Arjen M, White, Nicholas J, and von Seidlein, Lorenz

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Vector-Borne Diseases, Prevention, Clinical Trials and Supportive Activities, Infectious Diseases, Clinical Research, Malaria, Infection, Good Health and Well Being, Adolescent, Adult, Antimalarials, Artemisinins, Cambodia, Child, Female, Humans, Malaria, Falciparum, Malaria, Vivax, Male, Mass Drug Administration, Myanmar, Prevalence, Primaquine, Quinolines, Recurrence, Treatment Outcome, Vietnam, Young Adult, General Science & Technology
Abstract

BackgroundMass administrations of antimalarial drugs (MDA) have reduced the incidence and prevalence of P. falciparum infections in a trial in the Greater Mekong Subregion. Here we assess the impact of the MDA on P. vivax infections.MethodsBetween May 2013 and July 2017, four villages in each Myanmar, Vietnam, Cambodia and Lao PDR were selected based on high prevalence of P. falciparum infections. Eight of the 16 villages were randomly assigned to receive MDA consisting of three-monthly rounds of three-day courses of dihydroartemisinin-piperaquine and, except in Cambodia, a single low-dose of primaquine. Cross-sectional surveys were conducted at quarterly intervals to detect Plasmodium infections using ultrasensitive qPCR. The difference in the cumulative incidence between the groups was assessed through a discrete time survival approach, the difference in prevalence through a difference-in-difference analysis, and the difference in the number of participants with a recurrence of P. vivax infection through a mixed-effect logistic regression.Results3,790 (86%) residents in the intervention villages participated in at least one MDA round, of whom 2,520 (57%) participated in three rounds. The prevalence of P. vivax infections fell from 9.31% to 0.89% at month 3 but rebounded by six months to 5.81%. There was no evidence that the intervention reduced the cumulative incidence of P.vivax infections (95% confidence interval [CI] Odds ratio (OR): 0.29 to 1.36). Similarly, there was no evidence of MDA related reduction in the number of participants with at least one recurrent infection (OR: 0.34; 95% CI: 0.08 to 1.42).ConclusionMDA with schizontocidal drugs had a lasting effect on P. falciparum infections but only a transient effect on the prevalence of P. vivax infections. Radical cure with an 8-aminoquinoline will be needed for the rapid elimination of vivax malaria.

Published
2020

8. Antimalarial chemoprophylaxis for forest goers in southeast Asia: an open-label, individually randomised controlled trial

Author

Tripura, Rupam, von Seidlein, Lorenz, Sovannaroth, Siv, Peto, Thomas J, Callery, James J, Sokha, Meas, Ean, Mom, Heng, Chhouen, Conradis-Jansen, Franca, Madmanee, Wanassanan, Peerawaranun, Pimnara, Waithira, Naomi, Khonputsa, Panarasri, Jongdeepaisal, Monnaphat, Pongsoipetch, Kulchada, Chotthanawathit, Paphapisa, Soviet, Ung, Pell, Christopher, Duanguppama, Jureeporn, Rekol, Huy, Tarning, Joel, Imwong, Mallika, Mukaka, Mavuto, White, Nicholas J, Dondorp, Arjen M, and Maude, Richard J

Published
2023
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10. The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial.

Author

von Seidlein, Lorenz, Peto, Thomas J, Landier, Jordi, Nguyen, Thuy-Nhien, Tripura, Rupam, Phommasone, Koukeo, Pongvongsa, Tiengkham, Lwin, Khin Maung, Keereecharoen, Lilly, Kajeechiwa, Ladda, Thwin, May Myo, Parker, Daniel M, Wiladphaingern, Jacher, Nosten, Suphak, Proux, Stephane, Corbel, Vincent, Tuong-Vy, Nguyen, Phuc-Nhi, Truong Le, Son, Do Hung, Huong-Thu, Pham Nguyen, Tuyen, Nguyen Thi Kim, Tien, Nguyen Thanh, Dong, Le Thanh, Hue, Dao Van, Quang, Huynh Hong, Nguon, Chea, Davoeung, Chan, Rekol, Huy, Adhikari, Bipin, Henriques, Gisela, Phongmany, Panom, Suangkanarat, Preyanan, Jeeyapant, Atthanee, Vihokhern, Benchawan, van der Pluijm, Rob W, Lubell, Yoel, White, Lisa J, Aguas, Ricardo, Promnarate, Cholrawee, Sirithiranont, Pasathorn, Malleret, Benoit, Rénia, Laurent, Onsjö, Carl, Chan, Xin Hui, Chalk, Jeremy, Miotto, Olivo, Patumrat, Krittaya, Chotivanich, Kesinee, Hanboonkunupakarn, Borimas, Jittmala, Podjanee, Kaehler, Nils, Cheah, Phaik Yeong, Pell, Christopher, Dhorda, Mehul, Imwong, Mallika, Snounou, Georges, Mukaka, Mavuto, Peerawaranun, Pimnara, Lee, Sue J, Simpson, Julie A, Pukrittayakamee, Sasithon, Singhasivanon, Pratap, Grobusch, Martin P, Cobelens, Frank, Smithuis, Frank, Newton, Paul N, Thwaites, Guy E, Day, Nicholas PJ, Mayxay, Mayfong, Hien, Tran Tinh, Nosten, Francois H, Dondorp, Arjen M, and White, Nicholas J

Subjects
Humans, Malaria, Falciparum, Antimalarials, Cluster Analysis, Cross-Over Studies, Drug Resistance, Multiple, Adolescent, Adult, Child, Asia, Southeastern, Female, Male, Young Adult, Disease Eradication, Mass Drug Administration, Malaria, Falciparum, Drug Resistance, Multiple, Asia, Southeastern, General & Internal Medicine, Medical and Health Sciences
Abstract

BackgroundThe emergence and spread of multidrug-resistant Plasmodium falciparum in the Greater Mekong Subregion (GMS) threatens global malaria elimination efforts. Mass drug administration (MDA), the presumptive antimalarial treatment of an entire population to clear the subclinical parasite reservoir, is a strategy to accelerate malaria elimination. We report a cluster randomised trial to assess the effectiveness of dihydroartemisinin-piperaquine (DP) MDA in reducing falciparum malaria incidence and prevalence in 16 remote village populations in Myanmar, Vietnam, Cambodia, and the Lao People's Democratic Republic, where artemisinin resistance is prevalent.Methods and findingsAfter establishing vector control and community-based case management and following intensive community engagement, we used restricted randomisation within village pairs to select 8 villages to receive early DP MDA and 8 villages as controls for 12 months, after which the control villages received deferred DP MDA. The MDA comprised 3 monthly rounds of 3 daily doses of DP and, except in Cambodia, a single low dose of primaquine. We conducted exhaustive cross-sectional surveys of the entire population of each village at quarterly intervals using ultrasensitive quantitative PCR to detect Plasmodium infections. The study was conducted between May 2013 and July 2017. The investigators randomised 16 villages that had a total of 8,445 residents at the start of the study. Of these 8,445 residents, 4,135 (49%) residents living in 8 villages, plus an additional 288 newcomers to the villages, were randomised to receive early MDA; 3,790 out of the 4,423 (86%) participated in at least 1 MDA round, and 2,520 out of the 4,423 (57%) participated in all 3 rounds. The primary outcome, P. falciparum prevalence by month 3 (M3), fell by 92% (from 5.1% [171/3,340] to 0.4% [12/2,828]) in early MDA villages and by 29% (from 7.2% [246/3,405] to 5.1% [155/3,057]) in control villages. Over the following 9 months, the P. falciparum prevalence increased to 3.3% (96/2,881) in early MDA villages and to 6.1% (128/2,101) in control villages (adjusted incidence rate ratio 0.41 [95% CI 0.20 to 0.84]; p = 0.015). Individual protection was proportional to the number of completed MDA rounds. Of 221 participants with subclinical P. falciparum infections who participated in MDA and could be followed up, 207 (94%) cleared their infections, including 9 of 10 with artemisinin- and piperaquine-resistant infections. The DP MDAs were well tolerated; 6 severe adverse events were detected during the follow-up period, but none was attributable to the intervention.ConclusionsAdded to community-based basic malaria control measures, 3 monthly rounds of DP MDA reduced the incidence and prevalence of falciparum malaria over a 1-year period in areas affected by artemisinin resistance. P. falciparum infections returned during the follow-up period as the remaining infections spread and malaria was reintroduced from surrounding areas. Limitations of this study include a relatively small sample of villages, heterogeneity between villages, and mobility of villagers that may have limited the impact of the intervention. These results suggest that, if used as part of a comprehensive, well-organised, and well-resourced elimination programme, DP MDA can be a useful additional tool to accelerate malaria elimination.Trial registrationClinicalTrials.gov NCT01872702.

Published
2019

11. Triple therapy with artemether–lumefantrine plus amodiaquine versus artemether–lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trial

Author

Peto, Thomas J, Tripura, Rupam, Callery, James J, Lek, Dysoley, Nghia, Ho Dang Trung, Nguon, Chea, Thuong, Nguyen Thi Huyen, van der Pluijm, Rob W, Dung, Nguyen Thi Phuong, Sokha, Meas, Van Luong, Vo, Long, Le Thanh, Sovann, Yok, Duanguppama, Jureeporn, Waithira, Naomi, Hoglund, Richard M, Chotsiri, Palang, Chau, Nguyen Hoang, Ruecker, Andrea, Amaratunga, Chanaki, Dhorda, Mehul, Miotto, Olivo, Maude, Richard J, Rekol, Huy, Chotivanich, Kesinee, Tarning, Joel, von Seidlein, Lorenz, Imwong, Mallika, Mukaka, Mavuto, Day, Nicholas P J, Hien, Tran Tinh, White, Nicholas J, and Dondorp, Arjen M

Published
2022
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12. Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning

Author

Das, Debashish, Vongpromek, Ranitha, Assawariyathipat, Thanawat, Srinamon, Ketsanee, Kennon, Kalynn, Stepniewska, Kasia, Ghose, Aniruddha, Sayeed, Abdullah Abu, Faiz, M. Abul, Netto, Rebeca Linhares Abreu, Siqueira, Andre, Yerbanga, Serge R., Ouédraogo, Jean Bosco, Callery, James J., Peto, Thomas J., Tripura, Rupam, Koukouikila-Koussounda, Felix, Ntoumi, Francine, Ong’echa, John Michael, Ogutu, Bernhards, Ghimire, Prakash, Marfurt, Jutta, Ley, Benedikt, Seck, Amadou, Ndiaye, Magatte, Moodley, Bhavani, Sun, Lisa Ming, Archasuksan, Laypaw, Proux, Stephane, Nsobya, Sam L., Rosenthal, Philip J., Horning, Matthew P., McGuire, Shawn K., Mehanian, Courosh, Burkot, Stephen, Delahunt, Charles B., Bachman, Christine, Price, Ric N., Dondorp, Arjen M., Chappuis, François, Guérin, Philippe J., and Dhorda, Mehul

Published
2022
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14. Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

Author

Zhu, Lei, van der Pluijm, Rob W., Kucharski, Michal, Nayak, Sourav, Tripathi, Jaishree, White, Nicholas J., Day, Nicholas P. J., Faiz, Abul, Phyo, Aung Pyae, Amaratunga, Chanaki, Lek, Dysoley, Ashley, Elizabeth A., Nosten, François, Smithuis, Frank, Ginsburg, Hagai, von Seidlein, Lorenz, Lin, Khin, Imwong, Mallika, Chotivanich, Kesinee, Mayxay, Mayfong, Dhorda, Mehul, Nguyen, Hoang Chau, Nguyen, Thuy Nhien Thanh, Miotto, Olivo, Newton, Paul N., Jittamala, Podjanee, Tripura, Rupam, Pukrittayakamee, Sasithon, Peto, Thomas J., Hien, Tran Tinh, Dondorp, Arjen M., and Bozdech, Zbynek

Published
2022
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15. A multi-level spatial analysis of clinical malaria and subclinical Plasmodium infections in Pailin Province, Cambodia.

Author

Parker, Daniel M, Tripura, Rupam, Peto, Thomas J, Maude, Richard J, Nguon, Chea, Chalk, Jeremy, Sirithiranont, Pasathorn, Imwong, Mallika, von Seidlein, Lorenz, White, Nicholas J, and Dondorp, Arjen M

Subjects
Geography, Infectious disease, Information science, Public health, Clinical Research, Prevention, Infectious Diseases, Malaria, Rare Diseases, Vector-Borne Diseases, Infection
Abstract

Background:The malaria burden is decreasing throughout the Greater Mekong Subregion, however transmission persists in some areas. Human movement, subclinical infections and complicated transmission patterns contribute to the persistence of malaria. This research describes the micro-geographical epidemiology of both clinical malaria and subclinical Plasmodium infections in three villages in Western Cambodia. Methods:Three villages in Western Cambodia were selected for the study based on high reported Plasmodium falciparum incidence. A census was conducted at the beginning of the study, including demographic information and travel history. The total population was 1766. Cross-sectional surveys were conducted every three months from June 2013 to June 2014. Plasmodium infections were detected using an ultra-sensitive, high-volume, quantitative polymerase chain reaction (uPCR) technique. Clinical episodes were recorded by village health workers. The geographic coordinates (latitude and longitude) were collected for all houses and all participants were linked to their respective houses using a demographic surveillance system. Written informed consent was obtained from all participants. Results:Most clinical episodes and subclinical infections occurred within a single study village. Clinical Plasmodium vivax episodes clustered spatially in each village but only lasted for a month. In one study village subclinical infections clustered in geographic proximity to clusters of clinical episodes. The largest risk factor for clinical P. falciparum episodes was living in a house where another clinical P. falciparum episode occurred (model adjusted odds ratio (AOR): 6.9; CI: 2.3-19. 8). Subclinical infections of both P. vivax and P. falciparum were associated with clinical episodes of the same species (AOR: 5.8; CI: 1.5-19.7 for P. falciparum and AOR: 14.6; CI: 8.6-25.2 for P. vivax) and self-reported overnight visits to forested areas (AOR = 3.8; CI: 1.8-7. 7 for P. falciparum and AOR = 2.9; CI: 1.7-4.8 for P. vivax). Discussion:Spatial clustering within the villages was transient, making the prediction of spatial clusters difficult. Interventions that are dependent on predicting spatial clusters (such as reactive case detection) would only have detected a small proportion of cases unless the entire village was screened within a limited time frame and with a highly sensitive diagnostic test. Subclinical infections may be acquired outside of the village (particularly in forested areas) and may play an important role in transmission.

Published
2017

16. Molecular epidemiology of resistance to antimalarial drugs in the Greater Mekong subregion: an observational study

Author

Imwong, Mallika, Dhorda, Mehul, Myo Tun, Kyaw, Thu, Aung Myint, Phyo, Aung Pyae, Proux, Stephane, Suwannasin, Kanokon, Kunasol, Chanon, Srisutham, Suttipat, Duanguppama, Jureeporn, Vongpromek, Ranitha, Promnarate, Cholrawee, Saejeng, Aungkana, Khantikul, Nardlada, Sugaram, Rungniran, Thanapongpichat, Supinya, Sawangjaroen, Nongyao, Sutawong, Kreepol, Han, Kay Thwe, Htut, Ye, Linn, Khin, Win, Aye Aye, Hlaing, Tin M, van der Pluijm, Rob W, Mayxay, Mayfong, Pongvongsa, Tiengkham, Phommasone, Koukeo, Tripura, Rupam, Peto, Thomas J, von Seidlein, Lorenz, Nguon, Chea, Lek, Dysoley, Chan, Xin Hui S, Rekol, Huy, Leang, Rithea, Huch, Cheah, Kwiatkowski, Dominic P, Miotto, Olivo, Ashley, Elizabeth A, Kyaw, Myat Phone, Pukrittayakamee, Sasithon, Day, Nicholas P J, Dondorp, Arjen M, Smithuis, Frank M, Nosten, Francois H, and White, Nicholas J

Published
2020
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17. Ethical and cultural implications for conducting verbal autopsies in South and Southeast Asia: a qualitative study

Author

Htun, Nan Shwe Nwe, primary, Perrone, Carlo, additional, Phyo, Aung Pyae, additional, Sen, Aninda, additional, Phommasone, Koukeo, additional, Vanna, Moul, additional, Kanthawang, Nipaphan, additional, Sappayabanphot, Jarntrah, additional, Yotyingaphiram, Widi, additional, Wirachonphaophong, Jindaporn, additional, Kabir, Nawrin, additional, Ol, Sam, additional, Xaiyaphet, Xaipasong, additional, Soulivong, Ailatda, additional, Seevanhthong, Khambang, additional, Tripura, Rupam, additional, Chew, Rusheng, additional, Khirikoekkong, Napat, additional, Morris, Shaun K, additional, Osterrieder, Anne, additional, Cheah, Phaik Yeong, additional, Jha, Prabhat, additional, Lubell, Yoel, additional, and Peto, Thomas J, additional

Published
2023
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20. Development of weight and age-based dosing of daily primaquine for radical cure of vivax malaria

Author

Taylor, Walter Robert, Hoglund, Richard M., Peerawaranun, Pimnara, Nguyen, Thuy Nhien, Hien, Tran Tinh, Tarantola, Arnaud, von Seidlein, Lorenz, Tripura, Rupam, Peto, Thomas J., Dondorp, Arjen M., Landier, Jordi, H.Nosten, Francois, Smithuis, Frank, Phommasone, Koukeo, Mayxay, Mayfong, Kheang, Soy Ty, Say, Chy, Neeraj, Kak, Rithea, Leang, Dysoley, Lek, Kheng, Sim, Muth, Sinoun, Roca-Feltrer, Arantxa, Debackere, Mark, Fairhurst, Rick M., Song, Ngak, Buchy, Philippe, Menard, Didier, White, Nicholas J., Tarning, Joel, and Mukaka, Mavuto

Published
2021
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21. Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study

Author

van der Pluijm, Rob W, Imwong, Mallika, Chau, Nguyen Hoang, Hoa, Nhu Thi, Thuy-Nhien, Nguyen Thanh, Thanh, Ngo Viet, Jittamala, Podjanee, Hanboonkunupakarn, Borimas, Chutasmit, Kitipumi, Saelow, Chalermpon, Runjarern, Ratchadaporn, Kaewmok, Weerayuth, Tripura, Rupam, Peto, Thomas J, Yok, Sovann, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Oun, Savuth, Yen, Sovannary, Amaratunga, Chanaki, Lek, Dysoley, Huy, Rekol, Dhorda, Mehul, Chotivanich, Kesinee, Ashley, Elizabeth A, Mukaka, Mavuto, Waithira, Naomi, Cheah, Phaik Yeong, Maude, Richard J, Amato, Roberto, Pearson, Richard D, Gonçalves, Sónia, Jacob, Christopher G, Hamilton, William L, Fairhurst, Rick M, Tarning, Joel, Winterberg, Markus, Kwiatkowski, Dominic P, Pukrittayakamee, Sasithon, Hien, Tran Tinh, Day, Nicholas PJ, Miotto, Olivo, White, Nicholas J, and Dondorp, Arjen M

Published
2019
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22. Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study

Author

Hamilton, William L, Amato, Roberto, van der Pluijm, Rob W, Jacob, Christopher G, Quang, Huynh Hong, Thuy-Nhien, Nguyen Thanh, Hien, Tran Tinh, Hongvanthong, Bouasy, Chindavongsa, Keobouphaphone, Mayxay, Mayfong, Huy, Rekol, Leang, Rithea, Huch, Cheah, Dysoley, Lek, Amaratunga, Chanaki, Suon, Seila, Fairhurst, Rick M, Tripura, Rupam, Peto, Thomas J, Sovann, Yok, Jittamala, Podjanee, Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Chau, Nguyen Hoang, Imwong, Mallika, Dhorda, Mehul, Vongpromek, Ranitha, Chan, Xin Hui S, Maude, Richard J, Pearson, Richard D, Nguyen, T, Rockett, Kirk, Drury, Eleanor, Gonçalves, Sónia, White, Nicholas J, Day, Nicholas P, Kwiatkowski, Dominic P, Dondorp, Arjen M, and Miotto, Olivo

Published
2019
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24. Expanding the role of village malaria workers in Cambodia: Implementation and evaluation of four health education packages

Author

Betrian, Mipharny, primary, Umans, Dafne, additional, Vanna, Moul, additional, Ol, Sam, additional, Adhikari, Bipin, additional, Davoeung, Chan, additional, Callery, James J., additional, Sovann, Yok, additional, Peto, Thomas J., additional, Maude, Richard J., additional, van der Pluijm, Rob W., additional, Bunreth, Voeunrung, additional, Grobusch, Martin P., additional, van Vugt, Michèle, additional, Lubell, Yoel, additional, von Seidlein, Lorenz, additional, Dondorp, Arjen M., additional, Sovannaroth, Siv, additional, Lek, Dysoley, additional, and Tripura, Rupam, additional

Published
2023
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26. Artemisinin-resistant malaria in Africa demands urgent action.

Author

Dhorda, Mehul, Akira Kaneko, Ryuichi Komatsu, K. C., Achyut, Mshamu, Salum, Gesase, Samwel, Kapologwe, Ntuli, Assefa, Ashenafi, Opigo, Jimmy, Adoke, Yeka, Ebong, Chris, Karema, Corine, Uwimana, Aline, Mangara, Jean-Louis Ndikumana, Amaratunga, Chanaki, Peto, Thomas J., Tripura, Rupam, Callery, James J., Adhikari, Bipin, and Mukaka, Mavuto

Published
2024
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27. The feasibility of novel point-of-care diagnostics for febrile illnesses at health centres in Southeast Asia: a mixed-methods study

Author

Adella, Fidelis Jacklyn, primary, Vanna, Moul, additional, Adhikari, Bipin, additional, Ol, Sam, additional, Tripura, Rupam, additional, Davoeung, Chan, additional, Callery, James J, additional, Sovann, Yok, additional, Chandna, Arjun, additional, Bunreth, Voeunrung, additional, Asnong, Carina, additional, von Seidlein, Lorenz, additional, Dondorp, Arjen M, additional, Maude, Richard J, additional, Lubell, Yoel, additional, Wills, Bridget, additional, Lek, Dysoley, additional, and Peto, Thomas J, additional

Published
2023
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28. Community engagement among forest goers in a malaria prophylaxis trial: implementation challenges and implications

Author

Conradis-Jansen, Franca, primary, Tripura, Rupam, additional, Peto, Thomas J., additional, Callery, James J., additional, Adhikari, Bipin, additional, Ean, Mom, additional, Jongdeepaisal, Monnaphat, additional, Pell, Christopher, additional, Khonputsa, Panarasri, additional, Murgia, Riccardo, additional, Sovannaroth, Siv, additional, Müller, Olaf, additional, Cheah, Phaik Yeong, additional, Dondorp, Arjen M., additional, von Seidlein, Lorenz, additional, and Maude, Richard J., additional

Published
2023
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29. Tools to accelerate falciparum malaria elimination in Cambodia: a meeting report

Author

Lek, Dysoley, Callery, James J., Nguon, Chea, Debackere, Mark, Sovannaroth, Siv, Tripura, Rupam, Wojnarski, Marius, Piola, Patrice, Khean, Soy Ty, Manion, Kylie, Nguon, Sokomar, Kunkel, Amber, Vernaeve, Lieven, Peto, Thomas J., Dantzer, Emily, Davoeung, Chan, Etienne, William, Dondorp, Arjen M., Tuseo, Luciano, von Seidlein, Lorenz, and Guintran, Jean-Olivier

Published
2020
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30. Correction to: The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR

Author

Phommasone, Koukeo, van Leth, Frank, Imwong, Mallika, Henriques, Gisela, Pongvongsa, Tiengkham, Adhikari, Bipin, Peto, Thomas J., Promnarate, Cholrawee, Dhorda, Mehul, Sirithiranont, Pasathorn, Mukaka, Mavuto, Peerawaranun, Pimnara, Day, Nicholas P. J., Cobelens, Frank, Dondorp, Arjen M., Newton, Paul N., White, Nicholas J., von Seidlein, Lorenz, and Mayxay, Mayfong

Published
2020
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31. The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR

Author

Phommasone, Koukeo, van Leth, Frank, Imwong, Mallika, Henriques, Gisela, Pongvongsa, Tiengkham, Adhikari, Bipin, Peto, Thomas J., Promnarate, Cholrawee, Dhorda, Mehul, Sirithiranont, Pasathorn, Mukaka, Mavuto, Peerawaranun, Pimnara, Day, Nicholas P. J., Cobelens, Frank, Dondorp, Arjen M., Newton, Paul N., White, Nicholas J., von Seidlein, Lorenz, and Mayxay, Mayfong

Published
2020
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32. The probability of a sequential Plasmodium vivax infection following asymptomatic Plasmodium falciparum and P. vivax infections in Myanmar, Vietnam, Cambodia, and Laos

Author

von Seidlein, Lorenz, Peerawaranun, Pimnara, Mukaka, Mavuto, Nosten, Francois H., Nguyen, Thuy-Nhien, Hien, Tran Tinh, Tripura, Rupam, Peto, Thomas J., Pongvongsa, Tiengkham, Phommasone, Koukeo, Mayxay, Mayfong, Imwong, Mallika, Watson, James, Pukrittayakamee, Sasithon, Day, Nicholas P. J., and Dondorp, Arjen M.

Published
2019
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34. Glucose-6-Phosphate Dehydrogenase (G6PD) Measurement Using Biosensors by Community-Based Village Malaria Workers and Hospital Laboratory Staff in Cambodia: A Quantitative Study

Author

Adhikari, Bipin, primary, Tripura, Rupam, additional, Dysoley, Lek, additional, Peto, Thomas J., additional, Callery, James J., additional, Heng, Chhoeun, additional, Vanda, Thy, additional, Simvieng, Ou, additional, Cassidy-Seyoum, Sarah, additional, Thriemer, Kamala, additional, Dondorp, Arjen M., additional, Ley, Benedikt, additional, and Seidlein, Lorenz von, additional

Published
2023
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35. Numerical Distributions of Parasite Densities During Asymptomatic Malaria

Author

Imwong, Mallika, Stepniewska, Kasia, Tripura, Rupam, Peto, Thomas J., Lwin, Khin Maung, Vihokhern, Benchawan, Wongsaen, Klanarong, von Seidlein, Lorenz, Dhorda, Mehul, Snounou, Georges, Keereecharoen, Lilly, Singhasivanon, Pratap, Sirithiranont, Pasathorn, Chalk, Jem, Nguon, Chea, Day, Nicholas P. J., Nosten, Francois, Dondorp, Arjen, and White, Nicholas J.

Published
2016

39. Effectiveness of community engagement among forest goers in a malaria prophylaxis trial: Implementation challenges and implications

Author

Conradis-Jansen, Franca, primary, Tripura, Rupam, additional, Peto, Thomas J, additional, Callery, James J, additional, Adhikari, Bipin, additional, Eam, Mom, additional, Jongdeepaisal, Monnaphat, additional, Pell, Christopher, additional, Khonputsa, Panarasri, additional, Murgia, Riccardo, additional, Sovannaroth, Siv, additional, Müller, Olaf, additional, Cheah, Phaik Yeong, additional, Dondorp, Arjen M, additional, von Seidlein, Lorenz, additional, and Maude, Richard James, additional

Published
2023
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41. Ten-year persistence and evolution of Plasmodium falciparum antifolate and anti-sulfonamide resistance markers pfdhfr and pfdhps in three Asian countries

Author

Srisutham, Suttipat, primary, Madmanee, Wanassanan, additional, Kouhathong, Jindarat, additional, Sutawong, Kreepol, additional, Tripura, Rupam, additional, Peto, Thomas J., additional, van der Pluijm, Rob W., additional, Callery, James J., additional, Dysoley, Lek, additional, Mayxay, Mayfong, additional, Newton, Paul N., additional, Pongvongsa, Tiengkham, additional, Hongvanthong, Bouasy, additional, Day, Nicholas P. J., additional, White, Nicholas J., additional, Dondorp, Arjen M., additional, and Imwong, Mallika, additional

Published
2022
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42. Comparison of glucose-6 phosphate dehydrogenase status by fluorescent spot test and rapid diagnostic test in Lao PDR and Cambodia

Author

Henriques, Gisela, Phommasone, Koukeo, Tripura, Rupam, Peto, Thomas J., Raut, Shristi, Snethlage, Coco, Sambo, Im, Sanann, Nou, Nguon, Chea, Adhikari, Bipin, Pongvongsa, Tiengkham, Imwong, Mallika, von Seidlein, Lorenz, Day, Nicholas P., White, Nicholas J., Dondorp, Arjen M., Newton, Paul, Ley, Benedikt, and Mayxay, Mayfong

Published
2018
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45. Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project

Author

Chandna, Arjun, primary, Chew, Rusheng, additional, Shwe Nwe Htun, Nan, additional, Peto, Thomas J., additional, Zhang, Meiwen, additional, Liverani, Marco, additional, Brummaier, Tobias, additional, Phommasone, Koukeo, additional, Perrone, Carlo, additional, Pyae Phyo, Aung, additional, Sattabongkot, Jetsumon, additional, Roobsoong, Wanlapa, additional, Nguitragool, Wang, additional, Sen, Aninda, additional, Ibna Zaman, Sazid, additional, Sandar Zaw, Aye, additional, Batty, Elizabeth, additional, Waithira, Naomi, additional, Abdad, Mohammad Yazid, additional, Blacksell, Stuart D., additional, Bodhidatta, Ladaporn, additional, Callery, James J., additional, Fagnark, Watcharintorn, additional, Huangsuranun, Witchayoot, additional, Islam, Shayla, additional, Lertcharoenchoke, Sanchai, additional, Lohavittayavikant, Salisa, additional, Mukaka, Mavuto, additional, Moul, Vanna, additional, Kumer Neogi, Amit, additional, Nedsuwan, Supalert, additional, Pongvongsa, Tiengkham, additional, Ponsap, Pimsiri, additional, Richard-Greenblatt, Melissa, additional, Schilling, William H.K., additional, Thaipadungpanit, Janjira, additional, Tripura, Rupam, additional, Dondorp, Arjen M., additional, Mayxay, Mayfong, additional, White, Nicholas J., additional, Nosten, François, additional, Smithuis, Frank, additional, Ashley, Elizabeth A., additional, Maude, Richard J., additional, Day, Nicholas P.J., additional, and Lubell, Yoel, additional

Published
2022
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46. Additional file 2 of Glucose 6 Phosphate Dehydrogenase (G6PD) quantitation using biosensors at the point of first contact: a mixed method study in Cambodia

Author

Adhikari, Bipin, Tripura, Rupam, Dysoley, Lek, Callery, James J., Peto, Thomas J., Heng, Chhoeun, Vanda, Thy, Simvieng, Ou, Cassidy-Seyoum, Sarah, Ley, Benedikt, Thriemer, Kamala, Dondorp, Arjen M., and von Seidlein, Lorenz

Abstract

Additional file 2: Observation based quantitative questionnaire at the community setting.

Published
2022
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47. Additional file 2 of Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning

Author

Das, Debashish, Vongpromek, Ranitha, Assawariyathipat, Thanawat, Srinamon, Ketsanee, Kennon, Kalynn, Stepniewska, Kasia, Ghose, Aniruddha, Sayeed, Abdullah Abu, Faiz, M. Abul, Netto, Rebeca Linhares Abreu, Siqueira, Andre, Yerbanga, Serge R., Ouédraogo, Jean Bosco, Callery, James J., Peto, Thomas J., Tripura, Rupam, Koukouikila-Koussounda, Felix, Ntoumi, Francine, Ong’echa, John Michael, Ogutu, Bernhards, Ghimire, Prakash, Marfurt, Jutta, Ley, Benedikt, Seck, Amadou, Ndiaye, Magatte, Moodley, Bhavani, Sun, Lisa Ming, Archasuksan, Laypaw, Proux, Stephane, Nsobya, Sam L., Rosenthal, Philip J., Horning, Matthew P., McGuire, Shawn K., Mehanian, Courosh, Burkot, Stephen, Delahunt, Charles B., Bachman, Christine, Price, Ric N., Dondorp, Arjen M., Chappuis, François, Guérin, Philippe J., and Dhorda, Mehul

Abstract

Additional file 2. Parasite Density Estimation.

Published
2022
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48. Additional file 3 of Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning

Author

Das, Debashish, Vongpromek, Ranitha, Assawariyathipat, Thanawat, Srinamon, Ketsanee, Kennon, Kalynn, Stepniewska, Kasia, Ghose, Aniruddha, Sayeed, Abdullah Abu, Faiz, M. Abul, Netto, Rebeca Linhares Abreu, Siqueira, Andre, Yerbanga, Serge R., Ouédraogo, Jean Bosco, Callery, James J., Peto, Thomas J., Tripura, Rupam, Koukouikila-Koussounda, Felix, Ntoumi, Francine, Ong’echa, John Michael, Ogutu, Bernhards, Ghimire, Prakash, Marfurt, Jutta, Ley, Benedikt, Seck, Amadou, Ndiaye, Magatte, Moodley, Bhavani, Sun, Lisa Ming, Archasuksan, Laypaw, Proux, Stephane, Nsobya, Sam L., Rosenthal, Philip J., Horning, Matthew P., McGuire, Shawn K., Mehanian, Courosh, Burkot, Stephen, Delahunt, Charles B., Bachman, Christine, Price, Ric N., Dondorp, Arjen M., Chappuis, François, Guérin, Philippe J., and Dhorda, Mehul

Abstract

Additional file 3. EasyScan Go.

Published
2022
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49. Additional file 1 of Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning

Author

Das, Debashish, Vongpromek, Ranitha, Assawariyathipat, Thanawat, Srinamon, Ketsanee, Kennon, Kalynn, Stepniewska, Kasia, Ghose, Aniruddha, Sayeed, Abdullah Abu, Faiz, M. Abul, Netto, Rebeca Linhares Abreu, Siqueira, Andre, Yerbanga, Serge R., Ouédraogo, Jean Bosco, Callery, James J., Peto, Thomas J., Tripura, Rupam, Koukouikila-Koussounda, Felix, Ntoumi, Francine, Ong’echa, John Michael, Ogutu, Bernhards, Ghimire, Prakash, Marfurt, Jutta, Ley, Benedikt, Seck, Amadou, Ndiaye, Magatte, Moodley, Bhavani, Sun, Lisa Ming, Archasuksan, Laypaw, Proux, Stephane, Nsobya, Sam L., Rosenthal, Philip J., Horning, Matthew P., McGuire, Shawn K., Mehanian, Courosh, Burkot, Stephen, Delahunt, Charles B., Bachman, Christine, Price, Ric N., Dondorp, Arjen M., Chappuis, François, Guérin, Philippe J., and Dhorda, Mehul

Abstract

Additional file 1. STARD-2015-Checklist.

Published
2022
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