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1. Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

Author

Honkoop, Hessel, primary, de Bakker, Dennis EM, additional, Aharonov, Alla, additional, Kruse, Fabian, additional, Shakked, Avraham, additional, Nguyen, Phong D, additional, de Heus, Cecilia, additional, Garric, Laurence, additional, Muraro, Mauro J, additional, Shoffner, Adam, additional, Tessadori, Federico, additional, Peterson, Joshua Craiger, additional, Noort, Wendy, additional, Bertozzi, Alberto, additional, Weidinger, Gilbert, additional, Posthuma, George, additional, Grün, Dominic, additional, van der Laarse, Willem J, additional, Klumperman, Judith, additional, Jaspers, Richard T, additional, Poss, Kenneth D, additional, van Oudenaarden, Alexander, additional, Tzahor, Eldad, additional, and Bakkers, Jeroen, additional more...

Published
2019
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2. Author response: Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

Author

Honkoop, Hessel, primary, de Bakker, Dennis EM, additional, Aharonov, Alla, additional, Kruse, Fabian, additional, Shakked, Avraham, additional, Nguyen, Phong D, additional, de Heus, Cecilia, additional, Garric, Laurence, additional, Muraro, Mauro J, additional, Shoffner, Adam, additional, Tessadori, Federico, additional, Peterson, Joshua Craiger, additional, Noort, Wendy, additional, Bertozzi, Alberto, additional, Weidinger, Gilbert, additional, Posthuma, George, additional, Grün, Dominic, additional, van der Laarse, Willem J, additional, Klumperman, Judith, additional, Jaspers, Richard T, additional, Poss, Kenneth D, additional, van Oudenaarden, Alexander, additional, Tzahor, Eldad, additional, and Bakkers, Jeroen, additional more...

Published
2019
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3. Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

Author

Honkoop, Hessel, de Bakker, Dennis Em, Aharonov, Alla, Kruse, Fabian, Shakked, Avraham, Nguyen, Phong D, de Heus, Cecilia, Garric, Laurence, Muraro, Mauro J, Shoffner, Adam, Tessadori, Federico, Peterson, Joshua Craiger, Noort, Wendy, Bertozzi, Alberto, Weidinger, Gilbert, Posthuma, George, Grun, Dominic, van der Laarse, Willem J, Klumperman, Judith, Jaspers, Richard T, Poss, Kenneth D, van Oudenaarden, Alexander, Tzahor, Eldad, Bakkers, Jeroen, Honkoop, Hessel, de Bakker, Dennis Em, Aharonov, Alla, Kruse, Fabian, Shakked, Avraham, Nguyen, Phong D, de Heus, Cecilia, Garric, Laurence, Muraro, Mauro J, Shoffner, Adam, Tessadori, Federico, Peterson, Joshua Craiger, Noort, Wendy, Bertozzi, Alberto, Weidinger, Gilbert, Posthuma, George, Grun, Dominic, van der Laarse, Willem J, Klumperman, Judith, Jaspers, Richard T, Poss, Kenneth D, van Oudenaarden, Alexander, Tzahor, Eldad, and Bakkers, Jeroen more...

Abstract

While the heart regenerates poorly in mammals, efficient heart regeneration occurs in zebrafish. Studies in zebrafish have resulted in a model in which preexisting cardiomyocytes dedifferentiate and reinitiate proliferation to replace the lost myocardium. To identify which processes occur in proliferating cardiomyocytes we have used a single-cell RNA-sequencing approach. We uncovered that proliferating border zone cardiomyocytes have very distinct transcriptomes compared to the nonproliferating remote cardiomyocytes and that they resemble embryonic cardiomyocytes. Moreover, these cells have reduced expression of mitochondrial genes and reduced mitochondrial activity, while glycolysis gene expression and glucose uptake are increased, indicative for metabolic reprogramming. Furthermore, we find that the metabolic reprogramming of border zone cardiomyocytes is induced by Nrg1/ErbB2 signaling and is important for their proliferation. This mechanism is conserved in murine hearts in which cardiomyocyte proliferation is induced by activating ErbB2 signaling. Together these results demonstrate that glycolysis regulates cardiomyocyte proliferation during heart regeneration. more...

Published
2019

4. Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

Author

Medische Fysiologie, Cancer, CMM Groep Klumperman, Child Health, Genetica Groep Van Haaften, CMM Sectie Celbiologie, Regenerative Medicine and Stem Cells, Brain, CMM Sectie Molecular Cancer Research, Hubrecht Institute with UMC, Circulatory Health, Honkoop, Hessel, de Bakker, Dennis Em, Aharonov, Alla, Kruse, Fabian, Shakked, Avraham, Nguyen, Phong D, de Heus, Cecilia, Garric, Laurence, Muraro, Mauro J, Shoffner, Adam, Tessadori, Federico, Peterson, Joshua Craiger, Noort, Wendy, Bertozzi, Alberto, Weidinger, Gilbert, Posthuma, George, Grun, Dominic, van der Laarse, Willem J, Klumperman, Judith, Jaspers, Richard T, Poss, Kenneth D, van Oudenaarden, Alexander, Tzahor, Eldad, Bakkers, Jeroen, Medische Fysiologie, Cancer, CMM Groep Klumperman, Child Health, Genetica Groep Van Haaften, CMM Sectie Celbiologie, Regenerative Medicine and Stem Cells, Brain, CMM Sectie Molecular Cancer Research, Hubrecht Institute with UMC, Circulatory Health, Honkoop, Hessel, de Bakker, Dennis Em, Aharonov, Alla, Kruse, Fabian, Shakked, Avraham, Nguyen, Phong D, de Heus, Cecilia, Garric, Laurence, Muraro, Mauro J, Shoffner, Adam, Tessadori, Federico, Peterson, Joshua Craiger, Noort, Wendy, Bertozzi, Alberto, Weidinger, Gilbert, Posthuma, George, Grun, Dominic, van der Laarse, Willem J, Klumperman, Judith, Jaspers, Richard T, Poss, Kenneth D, van Oudenaarden, Alexander, Tzahor, Eldad, and Bakkers, Jeroen more...

Published
2019