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1. Nutritional impairment, psychological health and quality of life among older adults with advanced cancer: A secondary analysis of a randomized clinical trial.

Author

Singhal, Surbhi, Wang, Ying, Qin, Zhaoyang, Peterson, Derick, Dunne, Richard, Culakova, Eva, Hopkins, Judith, Melnyk, Natalia, Onitilo, Adedayo, Targia, Valerie, Mohile, Supriya, and Loh, Kah

Subjects
nutritional impairment, older adults, psychological health, quality of life, Humans, Quality of Life, Aged, Male, Female, Neoplasms, Geriatric Assessment, Aged, 80 and over, Nutritional Status, Mental Health, Nutrition Assessment, Malnutrition, Palliative Care, Depression
Abstract

BACKGROUND: Nutritional impairment is associated with treatment toxicity and worse overall survival in patients with cancer. We aimed to (1) evaluate the association of nutritional impairment with psychological health and quality of life (QOL) and (2) examine which measures of nutrition had the strongest association with psychological health and QOL among older adults receiving cancer treatment with palliative intent. METHODS: This secondary analysis was performed on baseline data from a nationwide cluster randomized clinical trial (ClinicalTrials.gov identifier: NCT02107443; PI: Mohile). Adults age ≥70 with advanced cancer and ≥1 geriatric assessment (GA) impairment were enrolled from 2014 to 2017. In line with geriatric oncology standards, we defined nutritional impairment as Mini Nutritional Assessment Short Form (MNA-SF) ≤11, body mass index (BMI) 10% involuntary weight loss in the past 6 months. We conducted multivariable linear regressions to evaluate the association of nutritional impairment with each measure of psychological health and QOL: Geriatric Depression Scale (GDS-15, range 0-15), Generalized Anxiety Disorder-7 (GAD-7, range 0-21), NCCN Distress Thermometer (NCCN DT, range 0-10), and Functional Assessment of Cancer Therapy-General (FACT-G, range 0-108). Analyses were adjusted for patient demographics, clinical characteristics, and GA. RESULTS: Among 541 patients, the mean age was 77 (range 70-96) and 60% had nutritional impairment. Mean baseline scores: GDS-15 3.1 (SD 2.7), GAD-7 2.9 (SD 4.0), NCCN DT 2.9 (SD 2.7), and FACT-G 80 (SD 15). In the adjusted model, compared to those with no nutritional impairment, older adults with nutritional impairment had greater depression (β = 0.79, 95% CI 0.36-1.23) and anxiety severity (β = 0.86, 95% CI 0.19-1.53), and worse QOL (β = -6.31, 95% CI -8.62 to -4.00). Of the measures of nutrition, MNA-SF ≤11 demonstrated the strongest associations with depression, anxiety, distress, and QOL. CONCLUSION: Nutritional impairment is associated with impaired psychological health and worse QOL. Clinicians should use the MNA-SF to screen older adults for nutritional impairment and offer tailored supportive interventions.

Published
2024

4. Junctional AV ablation in patients with atrial fibrillation undergoing cardiac resynchronization therapy (JAVA-CRT): results of a multicenter randomized clinical trial pilot program

Author

Steinberg, Jonathan S., Gorcsan, John, Mazur, Alexander, Jain, Sandeep K., Rashtian, Mayer, Greer, G. Stephen, Zarraga, Ignatius, Vloka, Margot, Cook, Michele Murphy, Salam, Tariq, Mountantonakis, Stavros, Beck, Hiroko, Silver, Jonathan, Aktas, Mehmet, Henrikson, Charles, Schaller, Robert D., Epstein, Andrew E., McNitt, Scott, Schleede, Susan, Peterson, Derick, Goldenberg, Ilan, and Zareba, Wojciech

Published
2022
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5. Sex hormones and repolarization dynamics during the menstrual cycle in women with congenital long QT syndrome

Author

Bjelic, Milica, Zareba, Wojciech, Peterson, Derick R., Younis, Arwa, Aktas, Mehmet K., Huang, David T., Rosero, Spencer, Cutter, Kris, McNitt, Scott, Xia, Xiaojuan, MacKecknie, Bonnie D., Horn, Rebecca, Sotoodehnia, Nona, Kudenchuk, Peter J., Rea, Thomas D., Arking, Dan E., Wilde, Arthur A.M., Shimizu, Wataru, Ackerman, Michael J., and Goldenberg, Ilan

Published
2022
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6. Use of angiotensin converting enzyme inhibitors is associated with reduced risk of late bladder toxicity following radiotherapy for prostate cancer

Author

Azria, David, Briers, Erik, Chang-Claude, Jenny, Choudhury, Ananya, Dunning, Alison, Elliott, Rebecca M, Gutiérrez-Enríquez, Sara, Rancati, Tiziana, Rattay, Tim, Rosenstein, Barry S., De Ruysscher, Dirk, Seibold, Petra, Sperk, Elena, Paul Symonds, R, Stobart, Hilary, Talbot, Christopher J., Vega, Ana, Veldeman, Liv, Ward, Tim, Webb, Adam, West, Catharine M., Kerns, Sarah L., Amidon Morlang, Ashley, Lee, Sharon M., Peterson, Derick R., Marples, Brian, Zhang, Hong, Bylund, Kevin, Rosenzweig, Doug, Hall, William, De Ruyck, Kim, Stock, Richard G., Gómez-Caamaño, Antonio, Sosa-Fajardo, Paloma, Taboada-Valladares, Begoña, Aguado-Barrera, Miguel E., Parker, Chris, Fonteyne, Valérie, Bultijnck, Renée, Symonds, R. Paul, Johnson, Kerstie, Lambrecht, Maarten, de Ruysscher, Dirk, Vanneste, Ben, Elliott, Rebecca M., Herskind, Carsten, Veldwijk, Marlon R., Avuzzi, Barbara, Valdagni, Riccardo, Farcy Jacquet, Marie-Pierre, West, Catharine, Janelsins, Michelle, Chen, Yuhchyau, Messing, Edward, and Morrow, Gary

Published
2022
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9. Hyperbaric Oxygen (HBO) Effects on Blood Count Recovery and Post-Transplant Outcomes Following High-Dose Therapy and Autologous HSPC Transplantation for Multiple Myeloma: An Updated Analysis of the Multicenter Phase II Randomized Clinical Trial

Author

Shune, Leyla, primary, Qasrawi, Ayman, additional, Hildebrandt, Gerhard C, additional, Huselton, Eric, additional, Langstein, Howard, additional, Allin, Dennis, additional, Burrows, Ms. Kaitlyn, additional, Baran, Andrea, additional, Liesveld, Jane, additional, Blumberg, Neil, additional, Lipe, Brea, additional, Evans, Andrew, additional, Peterson, Derick, additional, and Aljitawi, Omar, additional

Published
2024
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10. Plasma phospholipids identify antecedent memory impairment in older adults

Author

Mapstone, Mark, Cheema, Amrita K, Fiandaca, Massimo S, Zhong, Xiaogang, Mhyre, Timothy R, MacArthur, Linda H, Hall, William J, Fisher, Susan G, Peterson, Derick R, Haley, James M, Nazar, Michael D, Rich, Steven A, Berlau, Dan J, Peltz, Carrie B, Tan, Ming T, Kawas, Claudia H, and Federoff, Howard J

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Clinical Research, Prevention, Acquired Cognitive Impairment, Aging, Brain Disorders, Neurosciences, Neurodegenerative, Dementia, Neurological, Aged, Alzheimer Disease, Asparagine, Biomarkers, Carnitine, Cognitive Dysfunction, Cohort Studies, Dipeptides, Female, Humans, Longitudinal Studies, Lysophosphatidylcholines, Malates, Male, Memory Disorders, Metabolome, Neuropsychological Tests, Phosphatidylcholines, Phosphatidylinositols, Phospholipids, Proline, Prospective Studies, Sensitivity and Specificity, Sphingomyelins, Ursodeoxycholic Acid, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences
Abstract

Alzheimer's disease causes a progressive dementia that currently affects over 35 million individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no cures or disease-modifying therapies, and this may be due to our inability to detect the disease before it has progressed to produce evident memory loss and functional decline. Biomarkers of preclinical disease will be critical to the development of disease-modifying or even preventative therapies. Unfortunately, current biomarkers for early disease, including cerebrospinal fluid tau and amyloid-β levels, structural and functional magnetic resonance imaging and the recent use of brain amyloid imaging or inflammaging, are limited because they are either invasive, time-consuming or expensive. Blood-based biomarkers may be a more attractive option, but none can currently detect preclinical Alzheimer's disease with the required sensitivity and specificity. Herein, we describe our lipidomic approach to detecting preclinical Alzheimer's disease in a group of cognitively normal older adults. We discovered and validated a set of ten lipids from peripheral blood that predicted phenoconversion to either amnestic mild cognitive impairment or Alzheimer's disease within a 2-3 year timeframe with over 90% accuracy. This biomarker panel, reflecting cell membrane integrity, may be sensitive to early neurodegeneration of preclinical Alzheimer's disease.

Published
2014

14. First dose infusion reaction during anti-CD20 monoclonal antibody therapy in chronic lymphocytic leukemia associates with high IP-10 levels amid cytokine release syndrome

Author

Chu, Charles C, primary, Moore, Jeremiah E., additional, Bloom, Paige C., additional, Bruno, Jennifer E., additional, Quataert, Sally A., additional, Mosmann, Tim R., additional, Jaimes-Delgadillo, Nydia, additional, Herne, Christine Ann, additional, VanDerMeid, Karl R., additional, Baran, Andrea M., additional, Peterson, Derick R., additional, Taylor, Ronald P, additional, Elliott, Michael Rusty, additional, Wallace, Danielle S., additional, Barr, Paul M., additional, and Zent, Clive S., additional

Published
2023
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16. CE-452779-3 RANDOMIZED PLACEBO-CONTROLLED TRIAL OF FLECAINIDE IN PATIENTS WITH ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY

Author

Zareba, Wojciech, primary, Tichnell, Crystal, additional, Rosero, Spencer Z., additional, Cerrone, Marina, additional, Zipse, Matthew M., additional, Marchlinski, Francis E., additional, Sun, Albert Y., additional, Indik, Julia H., additional, James, Cynthia A., additional, Mestroni, Luisa, additional, Cutter, Kristina, additional, Peterson, Derick R., additional, McNitt, Scott, additional, Polonsky, Bronislava, additional, Daubert, James P., additional, Haigney, Mark C., additional, Needleman, Matthew, additional, Oakes, David, additional, Delmar, Mario, additional, and Calkins, Hugh, additional

Published
2023
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21. Supplementary Figure Legends 1-6 from Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo

Author

Dasmahapatra, Girija, primary, Lembersky, Dmitry, primary, Son, Minkyeong P., primary, Patel, Hiral, primary, Peterson, Derick, primary, Attkisson, Elisa, primary, Fisher, Richard I., primary, Friedberg, Jonathan W., primary, Dent, Paul, primary, and Grant, Steven, primary

Published
2023
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26. Assessment of absolute risk of life-threatening cardiac events in long QT syndrome patients

Author

Wang, Meng, primary, Peterson, Derick R., additional, Pagan, Eleonora, additional, Bagnardi, Vincenzo, additional, Mazzanti, Andrea, additional, McNitt, Scott, additional, Rich, David Q., additional, Seplaki, Christopher L., additional, Kutyifa, Valentina, additional, Polonsky, Bronislava, additional, Barsheshet, Alon, additional, Kukavica, Deni, additional, Rosero, Spencer, additional, Goldenberg, Ilan, additional, Priori, Silvia, additional, and Zareba, Wojciech, additional

Published
2022
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30. Independent validation and clinical implications of the risk prediction model for long QT syndrome (1-2-3-LQTS-Risk)

Author

Mazzanti, A, Trancuccio, A, Kukavica, D, Pagan, E, Wang, M, Mohsin, M, Peterson, D, Bagnardi, V, Zareba, W, Priori, S, Mazzanti, Andrea, Trancuccio, Alessandro, Kukavica, Deni, Pagan, Eleonora, Wang, Meng, Mohsin, Muhammed, Peterson, Derick, Bagnardi, Vincenzo, Zareba, Wojciech, Priori, Silvia G, Mazzanti, A, Trancuccio, A, Kukavica, D, Pagan, E, Wang, M, Mohsin, M, Peterson, D, Bagnardi, V, Zareba, W, Priori, S, Mazzanti, Andrea, Trancuccio, Alessandro, Kukavica, Deni, Pagan, Eleonora, Wang, Meng, Mohsin, Muhammed, Peterson, Derick, Bagnardi, Vincenzo, Zareba, Wojciech, and Priori, Silvia G

Abstract

Aims: Risk stratification of patients with long QT syndrome (LQTS) represents a difficult task. In 2018, we proposed a granular estimate of the baseline 5-year risk of life-threatening arrhythmias (LAE) for patients with LQTS, based on the genotype (long QT syndrome Type 1, long QT syndrome Type 2, and long QT syndrome Type 3) and the duration of the QTc interval. We sought to externally validate a novel risk score model (1-2-3-LQTS-Risk model) in a geographically diverse cohort from the USA and to evaluate its performance and assess potential clinical implication of this novel model. Methods and results: The prognostic model (1-2-3-LQTS-Risk model) was derived using data from a prospective, single-centre longitudinal cohort study published in 2018 (discovery cohort) and was validated using an independent cohort of 1689 patients enrolled in the International LQTS Registry (Rochester NY, USA). The validation study revealed a C-index of 0.69 [95% confidence interval (CI): 0.61-0.77] in the validation cohort, when compared with C-index of 0.79 (95% CI: 0.70-0.88) in the discovery cohort. Adopting a 5-year risk ≥5%, as suggested by the ROC curve analysis as the most balanced threshold for implantable cardioverter-defibrillator (ICD) implantation, would result in a number needed to treat (NNT) of nine (NNT = 9; 95% CI: 6.3-13.6). Conclusion: The 1-2-3-LQTS-Risk model, the first validated 5-year risk score model for patients with LQTS, can be used to aid clinicians to identify patients at the highest risk of LAE who could benefit most from an ICD implant and avoid unnecessary implants.

Published
2022

31. Gene Expression Risk Scores for COVID-19 Illness Severity.

Author

Peterson, Derick R, Baran, Andrea M, Bhattacharya, Soumyaroop, Branche, Angela R, Croft, Daniel P, Corbett, Anthony M, Walsh, Edward E, Falsey, Ann R, and Mariani, Thomas J

Subjects
*COVID-19, *DISEASE risk factors, *GENE expression
Abstract

Background The correlates of coronavirus disease 2019 (COVID-19) illness severity following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are incompletely understood. Methods We assessed peripheral blood gene expression in 53 adults with confirmed SARS-CoV-2 infection clinically adjudicated as having mild, moderate, or severe disease. Supervised principal components analysis was used to build a weighted gene expression risk score (WGERS) to discriminate between severe and nonsevere COVID-19. Results Gene expression patterns in participants with mild and moderate illness were similar, but significantly different from severe illness. When comparing severe versus nonsevere illness, we identified >4000 genes differentially expressed (false discovery rate < 0.05). Biological pathways increased in severe COVID-19 were associated with platelet activation and coagulation, and those significantly decreased with T-cell signaling and differentiation. A WGERS based on 18 genes distinguished severe illness in our training cohort (cross-validated receiver operating characteristic-area under the curve [ROC-AUC] = 0.98), and need for intensive care in an independent cohort (ROC-AUC = 0.85). Dichotomizing the WGERS yielded 100% sensitivity and 85% specificity for classifying severe illness in our training cohort, and 84% sensitivity and 74% specificity for defining the need for intensive care in the validation cohort. Conclusions These data suggest that gene expression classifiers may provide clinical utility as predictors of COVID-19 illness severity. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Interim Analysis of a Pilot Study Evaluating the Safety and Tolerability of Hyperbaric Oxygen Therapy in Combination with Fludarabine and Melphalan Conditioning and Allogeneic Hematopoietic Cell Transplant

Author

Huselton, Eric, primary, Torres, Nancy, additional, Baran, Andrea, additional, Burrows, Kaitlyn, additional, Liesveld, Jane, additional, Mendler, Jason, additional, Peterson, Derick, additional, Langstein, Howard, additional, Evans, Andrew, additional, Becker, Michael, additional, and Aljitawi, Omar, additional

Published
2022
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34. Use of angiotensin converting enzyme inhibitors is associated with reduced risk of late bladder toxicity following radiotherapy for prostate cancer

Author

Kerns, Sarah L., primary, Amidon Morlang, Ashley, additional, Lee, Sharon M., additional, Peterson, Derick R., additional, Marples, Brian, additional, Zhang, Hong, additional, Bylund, Kevin, additional, Rosenzweig, Doug, additional, Hall, William, additional, De Ruyck, Kim, additional, Rosenstein, Barry S., additional, Stock, Richard G., additional, Gómez-Caamaño, Antonio, additional, Vega, Ana, additional, Sosa-Fajardo, Paloma, additional, Taboada-Valladares, Begoña, additional, Aguado-Barrera, Miguel E., additional, Parker, Chris, additional, Veldeman, Liv, additional, Fonteyne, Valérie, additional, Bultijnck, Renée, additional, Talbot, Christopher J., additional, Symonds, R. Paul, additional, Johnson, Kerstie, additional, Rattay, Tim, additional, Webb, Adam, additional, Lambrecht, Maarten, additional, de Ruysscher, Dirk, additional, Vanneste, Ben, additional, Choudhury, Ananya, additional, Elliott, Rebecca M., additional, Sperk, Elena, additional, Herskind, Carsten, additional, Veldwijk, Marlon R., additional, Rancati, Tiziana, additional, Avuzzi, Barbara, additional, Valdagni, Riccardo, additional, Azria, David, additional, Farcy Jacquet, Marie-Pierre, additional, Chang-Claude, Jenny, additional, Seibold, Petra, additional, West, Catharine, additional, Janelsins, Michelle, additional, Chen, Yuhchyau, additional, Messing, Edward, additional, Morrow, Gary, additional, Briers, Erik, additional, Dunning, Alison, additional, Elliott, Rebecca M, additional, Gutiérrez-Enríquez, Sara, additional, De Ruysscher, Dirk, additional, Paul Symonds, R, additional, Stobart, Hilary, additional, Ward, Tim, additional, and West, Catharine M., additional

Published
2022
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35. The highly selective Bruton tyrosine kinase inhibitor acalabrutinib leaves macrophage phagocytosis intact

Author

Pinney, Jonathan J., primary, Blick-Nitko, Sara K., additional, Baran, Andrea M., additional, Peterson, Derick R., additional, Whitehead, Hannah E., additional, Izumi, Raquel, additional, Munugalavadla, Veerendra, additional, Van DerMeid, Karl R., additional, Barr, Paul M., additional, Zent, Clive S., additional, Elliott, Michael R., additional, and Chu, Charles C., additional

Published
2022
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40. Gene Expression Risk Scores for COVID-19 Illness Severity

Author

Peterson, Derick R, primary, Baran, Andrea M, additional, Bhattacharya, Soumyaroop, additional, Branche, Angela R, additional, Croft, Daniel P, additional, Corbett, Anthony M, additional, Walsh, Edward E, additional, Falsey, Ann R, additional, and Mariani, Thomas J, additional

Published
2021
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49. Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy

Author

Kerns, Sarah L, Fachal, Laura, Dorling, Leila, Barnett, Gillian C, Baran, Andrea, Peterson, Derick R, Hollenberg, Michelle, Hao, Ke, Narzo, Antonio Di, Ahsen, Mehmet Eren, Pandey, Gaurav, Bentzen, Søren M, Janelsins, Michelle, Elliott, Rebecca M, Pharoah, Paul D P, Burnet, Neil G, Dearnaley, David P, Gulliford, Sarah L, Hall, Emma, Sydes, Matthew R, Aguado-Barrera, Miguel E, Gómez-Caamaño, Antonio, Carballo, Ana M, Peleteiro, Paula, Lobato-Busto, Ramón, Stock, Richard, Stone, Nelson N, Ostrer, Harry, Usmani, Nawaid, Singhal, Sandeep, Tsuji, Hiroshi, Imai, Takashi, Saito, Shiro, Eeles, Rosalind, DeRuyck, Kim, Parliament, Matthew, Dunning, Alison M, Vega, Ana, Rosenstein, Barry S, West, Catharine M L, Wilson, Leila [0000-0003-1214-8080], Pharoah, Paul [0000-0001-8494-732X], Dunning, Alison [0000-0001-6651-7166], and Apollo - University of Cambridge Repository

Subjects
Urologic Diseases, 0604 Genetics, Aging, Biomedical, Prevention, Prostate Cancer, Human Genome, Articles, Clinical Medicine and Science, Clinical Research, Genetics, 2.1 Biological and endogenous factors, 1112 Oncology and Carcinogenesis, Patient Safety, Cancer, Biotechnology
Abstract

Background A total of 10%–20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies. Methods We conducted an individual patient data meta-analysis of six genome-wide association studies (n = 3871) in men of European ancestry who underwent radiotherapy for prostate cancer. Radiotoxicities (increased urinary frequency, decreased urinary stream, hematuria, rectal bleeding) were graded prospectively. We used grouped relative risk models to test associations with approximately 6 million genotyped or imputed variants (time to first grade 2 or higher toxicity event). Variants with two-sided Pmeta less than 5 × 10−8 were considered statistically significant. Bayesian false discovery probability provided an additional measure of confidence. Statistically significant variants were evaluated in three Japanese cohorts (n = 962). All statistical tests were two-sided. Results Meta-analysis of the European ancestry cohorts identified three genomic signals: single nucleotide polymorphism rs17055178 with rectal bleeding (Pmeta = 6.2 × 10−10), rs10969913 with decreased urinary stream (Pmeta = 2.9 × 10−10), and rs11122573 with hematuria (Pmeta = 1.8 × 10−8). Fine-scale mapping of these three regions was used to identify another independent signal (rs147121532) associated with hematuria (Pconditional = 4.7 × 10−6). Credible causal variants at these four signals lie in gene-regulatory regions, some modulating expression of nearby genes. Previously identified variants showed consistent associations (rs17599026 with increased urinary frequency, rs7720298 with decreased urinary stream, rs1801516 with overall toxicity) in new cohorts. rs10969913 and rs17599026 had similar effects in the photon-treated Japanese cohorts. Conclusions This study increases the understanding of the architecture of common genetic variants affecting radiotoxicity, points to novel radio-pathogenic mechanisms, and develops risk models for testing in clinical studies. Further multinational radiogenomics studies in larger cohorts are worthwhile.

Published
2020

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