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5. Evaluating Differences in Whole Blood, Serum, and Urine Screening Tests for Zika Virus, Puerto Rico, USA, 2016

Author

Rosinger, Asher Y., Olson, Samantha M., Ellington, Sascha R., Perez-Padilla, Janice, Simeone, Regina M., Pedati, Caitlin S., Schroeder, Betsy A., Santiago, Gilberto A., Medina, Freddy A., Munoz-Jordan, Jorge L., Adams, Laura E., Galang, Romeo R., Valencia-Prado, Miguel, Bakkour, Sonia, Colon, Candimar, Goodwin, Mary, Meaney-Delman, Dana, Read, Jennifer S., Petersen, Lyle R., Jamieson, Denise J., Deseda, Carmen C., Honein, Margaret A., Rivera-Garcia, Brenda, and Shapiro-Mendoza, Carrie K.

Subjects
Blood -- Medical examination, Urine -- Analysis, Nucleic acids -- Testing, Serodiagnosis -- Comparative analysis, Medical screening -- Comparative analysis -- Methods, Health
Abstract

Zika virus (ZIKV) infection during pregnancy can cause severe brain and eye malformations and is associated with neurodevelopmental abnormalities in affected infants (1). Currently, ZIKV testing with concurrent dengue virus [...]

Published
2021
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7. Severe Acute Respiratory Syndrome Coronavirus 2 Seropositivity among Healthcare Personnel in Hospitals and Nursing Homes, Rhode Island, USA, July-August 2020

Author

Akinbami, Lara J., Chan, Philip A., Vuong, Nga, Sami, Samira, Lewis, Dawn, Sheridan, Philip E., Lukacs, Susan L., Mackey, Lisa, Grohskopf, Lisa A., Patel, Anita, and Petersen, Lyle R.

Subjects
Hospitals -- Health aspects -- Rhode Island, Medical personnel -- Health aspects, Nursing homes -- Health aspects, Health
Abstract

Healthcare personnel face higher risk of infection during the coronavirus disease (COVID-19) pandemic because of their essential role in identifying and treating persons affected (2,2). Although essential workers in many [...]

Published
2021
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8. Prevalence of SARS-CoV-2 Antibodies in First Responders and Public Safety Personnel, New York City, New York, USA, May-July 2020

Author

Sami, Samira, Akinbami, Lara J., Petersen, Lyle R., Crawley, Addie, Lukacs, Susan L., Weiss, Don, Henseler, Rebecca A., Vuong, Nga, Mackey, Lisa, Patel, Anita, Grohskopf, Lisa A., Morgenthau, Beth Maldin, Daskalakis, Demetre, and Pathela, Preeti

Subjects
First responders -- Health aspects, Medical personnel -- Health aspects, Health
Abstract

Coronavirus disease (COVID-19) was recognized in New York City (NYC), New York, USA, in late February 2020 and had spread throughout the community by March 2020 (1). First responders and [...]

Published
2021
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9. SARS-CoV-2 Infection and Mitigation Efforts among Office Workers, Washington, DC, USA

Author

Sami, Samira, Vuong, Nga, Miller, Halie, Priestley, Rachael, Payne, Matthew, Licata-Portentoso, Garrett, Drobeniuc, Jan, and Petersen, Lyle R.

Subjects
Epidemics -- Control -- United States, Occupational health and safety -- Management, Public health administration -- Evaluation, Company business management, Health
Abstract

On March 19, 2020, the Federal Emergency Management Agency (FEMA) activated the National Response Coordination Center in Washington, DC, USA, in response to the coronavirus disease (COVID-19) pandemic. At that [...]

Published
2021
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10. SARS-CoV-2 Seroprevalence among Healthcare, First Response, and Public Safety Personnel, Detroit Metropolitan Area, Michigan, USA, May-June 2020

Author

Akinbami, Lara J., Vuong, Nga, Petersen, Lyle R., Sami, Samira, Patel, Anita, Lukacs, Susan L., Mackey, Lisa, Grohskopf, Lisa A., Shehu, Amy, and Atas, Jenny

Subjects
Detroit, Michigan -- Health aspects, Epidemics -- Statistics -- Risk factors -- United States, Peace officers -- Statistics -- Health aspects, Medical personnel -- Statistics -- Health aspects, Health
Abstract

Healthcare, first response (e.g., firefighters, paramedics, emergency medical technicians), and public safety (e.g., law enforcement officers) personnel have served on the front lines of the coronavirus disease (COVID-19) pandemic response [...]

Published
2020
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15. Modes of Transmission of Zika Virus

Author

Gregory, Christopher J., Oduyebo, Titilope, Brault, Aaron C., Brooks, John T., Chung, Koo-Whang, Hills, Susan, Kuehnert, Matthew J., Mead, Paul, Meaney-Delman, Dana, Rabe, Ingrid, Staples, Erin, and Petersen, Lyle R.

Published
2017

17. Update : Interim Guidance for Health Care Providers Caring for Pregnant Women with Possible Zika Virus Exposure — United States (Including U.S. Territories), July 2017

Author

Oduyebo, Titilope, Polen, Kara D., Walke, Henry T., Reagan-Steiner, Sarah, Lathrop, Eva, Rabe, Ingrid B., Kuhnert-Tallman, Wendi L., Martin, Stacey W., Walker, Allison T., Gregory, Christopher J., Ades, Edwin W., Carroll, Darin S., Rivera, Maria, Perez-Padilla, Janice, Gould, Carolyn, Nemhauser, Jeffrey B., Beard, C. Ben, Harcourt, Jennifer L., Viens, Laura, Johansson, Michael, Ellington, Sascha R., Petersen, Emily, Smith, Laura A., Reichard, Jessica, Munoz-Jordan, Jorge, Beach, Michael J., Rose, Dale A., Barzilay, Ezra, Noonan-Smith, Michelle, Jamieson, Denise J., Zaki, Sherif R., Petersen, Lyle R., Honein, Margaret A., and Meaney-Delman, Dana

Published
2017

18. Zika Virus — 10 Public Health Achievements in 2016 and Future Priorities

Author

Oussayef, Nadia L., Pillai, Satish K., Honein, Margaret A., Beard, C. Ben, Bell, Beth, Boyle, Coleen A., Eisen, Lars M., Kohl, Katrin, Kuehnert, Matthew J., Lathrop, Eva, Martin, Stacey W., Martin, Rebecca, McAllister, Janet C., McClune, Elizabeth Pantino, Mead, Paul, Meaney-Delman, Dana, Petersen, Brett, Petersen, Lyle R., Polen, Kara N.D., Powers, Ann M., Redd, Stephen C., Sejvar, James J., Sharp, Tyler, Villanueva, Julie, and Jamieson, Denise J.

Published
2017

20. Update : Interim Guidance for Preconception Counseling and Prevention of Sexual Transmission of Zika Virus for Persons with Possible Zika Virus Exposure — United States, September 2016

Author

Petersen, Emily E., Meaney-Delman, Dana, Neblett-Fanfair, Robyn, Havers, Fiona, Oduyebo, Titilope, Hills, Susan L., Rabe, Ingrid B., Lambert, Amy, Abercrombie, Julia, Martin, Stacey W., Gould, Carolyn V., Oussayef, Nadia, Polen, Kara N.D., Kuehnert, Matthew J., Pillai, Satish K., Petersen, Lyle R., Honein, Margaret A., Jamieson, Denise J., and Brooks, John T.

Published
2016

27. List of Contributors

Author

Abrahamian, Fredrick M., primary, Aldape, Michael J., additional, Aldasoro, Edelweiss, additional, Allen, Upton D., additional, Al-Sum, Hythem, additional, Anadkat, Milan J., additional, Anders, Katherine, additional, Angelakis, Emmanouil, additional, Angus, Brian John, additional, Antoniadou, Anastasia, additional, Arena, Fabio, additional, Arends, Joop E., additional, Arribas, Jose R., additional, Artenstein, Andrew W., additional, Atherton, John C., additional, Aucott, John N., additional, Aw, Tar-Ching, additional, Babcock, Hilary M., additional, Bailey, Robin, additional, Bailey, Thomas C., additional, Banks, Adam Z., additional, Barillo, David J., additional, Barrette, Ernie-Paul, additional, Bauer, Martijn P., additional, Bayston, Roger, additional, Beard, C. Ben, additional, Beardsley, Justin, additional, Beeching, Nick J., additional, Bégué, Rodolfo E., additional, Beldi, Guido, additional, Benson, Constance A., additional, Berbari, Elie F., additional, Berenger, Jean-Michel, additional, Berger, Christoph, additional, Bernardino, Jose I., additional, Bille, Jacques, additional, Billioux, Alexander C., additional, Bitnun, Ari, additional, Blair, Iain, additional, Blanche, Stéphane, additional, Bleck, Thomas P., additional, Bleeker-Rovers, Chantal P., additional, Bleijenberg, Gijs, additional, Bloch, Karen C., additional, Blum, Johannes, additional, Blumberg, Emily A., additional, Bonomo, Robert A., additional, Bonten, Marc J.M., additional, Bourayou, Rafik, additional, Bouza, Emilio, additional, Brandt, K. Ashley, additional, Bretelle, Florence, additional, Brisse, Sylvain, additional, Britton, Warwick J., additional, Brook, Itzhak, additional, Brouwer, Matthijs C., additional, Browne, Sarah K., additional, Bryant, Amy E., additional, Bühler, Silja, additional, Bulger, Eileen M., additional, Buller, R. Mark L., additional, Burke, Leah A., additional, Burri, Christian, additional, Butler, Marcus W., additional, Calandra, Thierry, additional, Calfee, David P., additional, Calvo-Cano, Antonia, additional, Cameron, D. William, additional, Carcillo, Joseph A., additional, Carson, Gail, additional, Chambers, Stephen T., additional, Charrel, Remi N., additional, Nguyen, Vinh Chau Van, additional, Chevaliez, Stéphane, additional, Chiller, Tom M., additional, Christaki, Eirini, additional, Chung, Kevin K., additional, Clifford, David B., additional, Clumeck, Nathan, additional, Cohen, Jonathan, additional, Collinge, John, additional, Conlon, Christopher P., additional, Conrad, Curdin, additional, Cooke, Fiona J., additional, Cope, Jennifer Rittenhouse, additional, Corey, G. Ralph, additional, Cross, John H., additional, Cunha, Burke A., additional, Cunha, Cheston B., additional, D'Journo, Benoit, additional, Daikos, George L., additional, Daniels, Johannes M.A., additional, Davidson, Robert N., additional, Day, Nicholas P.J., additional, De Cock, Kevin M., additional, de Silva, Thushan I., additional, de Vries, Henry J.C., additional, de Wit, Stéphane, additional, Delaloye, Julie, additional, Denning, David W., additional, Dennis, David T., additional, Dhanireddy, Shireesha, additional, Dielubanza, Elodi J., additional, Diemert, David J., additional, Doganay, Mehmet, additional, Doherty, Tom, additional, Dolecek, Christiane, additional, Dondorp, Arjen M., additional, Douglas, Abby, additional, Drancourt, Michel, additional, Dubourg, Grégory, additional, Dudley, Michael N., additional, Durand, Guillaume, additional, Eckhardt, Benjamin J., additional, Efstratiou, Androulla, additional, Ekkelenkamp, Miquel B., additional, Eranki, Ambika, additional, Erdem, Hakan, additional, Escota, Gerome V., additional, Evans, Heather L., additional, Eziefula, Alice Chijioke, additional, Fenollar, Florence, additional, Fenwick, Alan, additional, Fierer, Joshua, additional, Finch, Roger G., additional, Fleckenstein, James M., additional, Forstner, Christina, additional, Foschi, Federico, additional, Fournier, Pierre-Edouard, additional, French, Martyn A., additional, Gage, Kenneth L., additional, Garcia, Lynne S., additional, Gascon, Joaquim, additional, Gastañaduy, Arturo S., additional, Gautret, Philippe, additional, Geisler, William M., additional, Ghanem, Khalil G., additional, Giani, Tommaso, additional, Giannella, Maddalena, additional, Gilliam, Bruce L., additional, Gilliet, Michel, additional, Glaser, Carol A., additional, Glupczynski, Youri, additional, Gnann, John W., additional, Goldstein, Ellie J.C., additional, Gottstein, Bruno, additional, Gouriet, Frederique, additional, Gravitt, Patti E., additional, Green, Michael D., additional, Green, Stephen T., additional, Groll, Andreas H., additional, Gulick, Roy M., additional, Gupta, Arjun, additional, Habib, Gilbert, additional, Harbarth, Stephan, additional, Harris, Marianne, additional, Hayden, Frederick G., additional, Hetem, David J., additional, Hill, Philip C., additional, Hirschel, Bernard, additional, Hodowanec, Aimee C., additional, Hoffart, Louis, additional, Hoffmann, Christian, additional, Holland, Steven M., additional, Horby, Peter W., additional, Horne, David J., additional, Hraiech, Sami, additional, Hull, Mark W., additional, Huttner, Angela, additional, Ingram, Richard J.M., additional, Islam, Jasmin, additional, Ison, Michael G., additional, James, Scott H., additional, Jenkins, Claire, additional, Jenkins, Stephen G., additional, Jensen, Jørgen Skov, additional, Johnston, Christine, additional, Jones, Theodore B., additional, Jordan, Stephen J., additional, Julian, Kathleen G., additional, Kato, Yasuyuki, additional, Kauffman, Carol A., additional, Kaye, Keith S., additional, Keane, Michael P., additional, Keeney, James, additional, Kelly, Paul, additional, Kent, Stephen J., additional, Kern, Winfried V., additional, Keynan, Yoav, additional, Kim, Andrea A., additional, Koné-Paut, Isabelle, additional, Kosmidis, Chris, additional, Kroes, Aloys C.M., additional, Kroon, Frank P., additional, Ksiazek, Thomas G., additional, Kuhlmann, F. Matthew, additional, Kuijper, Ed J., additional, Kwon, Jennie H., additional, Kyei, George B., additional, Lacombe, Karine, additional, Lagacé-Wiens, Philippe, additional, Lagier, Jean-Christophe, additional, Lamagni, Theresa, additional, Landraud, Luce, additional, Lanternier, Fanny, additional, LaPlante, Kerry L., additional, Lawn, Stephen D., additional, Lawrence, Steven J., additional, Leblebicioglu, Hakan, additional, Lee, Nelson, additional, Leggett, James E., additional, Lehours, Philippe, additional, Levy, Pierre-Yves, additional, Leyh, Rainer G., additional, Lillis, Rebecca A., additional, Limmathurotsakul, Direk, additional, Lin, Jennifer, additional, Lindquist, H.D. Alan, additional, Lipsky, Benjamin A., additional, Liscynesky, Christina, additional, Looney, David, additional, Lortholary, Olivier, additional, Lowy, Franklin D., additional, Luft, Benjamin J., additional, Mackowiak, Philip A., additional, MacPherson, Paul A., additional, Maghraoui-Slim, Valérie, additional, Mallon, Patrick W., additional, Mangino, Julie E., additional, Manuel, Oriol, additional, Marchetti, Oscar, additional, Marks, Kristen M., additional, Marr, Kieren A., additional, Marrazzo, Jeanne, additional, Marschall, Jonas, additional, Martin, David H., additional, Matonti, Frédéric, additional, Matulewicz, Richard S., additional, Mayer, Kenneth H., additional, McCulloh, Russell J., additional, McGready, Rose, additional, Mdodo, Rennatus, additional, Mead, Simon, additional, Mégraud, Francis, additional, Meintjes, Graeme, additional, Metcalf, Sarah C., additional, Michaels, Marian G., additional, Migliori, Giovanni Battista, additional, Miles, Michael A., additional, Miller, Alastair, additional, Mimiaga, Matthew J., additional, Mingeot-Leclercq, Marie-Paule, additional, Misch, Elizabeth Ann, additional, Mitreva, Makedonka, additional, Montaner, Julio S.G., additional, Moore, Caroline B., additional, Muñoz, Patricia, additional, Muñoz, Jose, additional, Murray, Clinton K., additional, Musso, Didier, additional, Mutengo, Mable, additional, Mutizwa, Misha M., additional, Naber, Kurt G., additional, Natarajan, Pavithra, additional, Neme, Santiago, additional, Newton, Paul N., additional, Nichols, Ronald A., additional, Nicolle, Lindsay E., additional, Nosten, François, additional, Notarangelo, Luigi D., additional, Nutman, Thomas B., additional, Nyirjesy, Paul, additional, O'Connell, P. Ronan, additional, Opal, Steven M., additional, Ormerod, L. Peter, additional, Osmon, Douglas R., additional, Pankert, Marie Boulze, additional, Pantaleo, Giuseppe, additional, Papazian, Laurent, additional, Parente, Diane M., additional, Parola, Philippe, additional, Parsaei, Shadi, additional, Pascual, Manuel A., additional, Patel, Rupa, additional, Patrozou, Eleni, additional, Pawlotsky, Jean-Michel, additional, Peacock, Sharon J., additional, Pechère, Jean-Claude, additional, Pelegrin, Ivan, additional, Peters, Barry S., additional, Peters, Edgar J.G., additional, Petersen, Jeannine M., additional, Petersen, Lyle R., additional, Petraitis, Vidmantas, additional, Pham, Luu-Ly, additional, Picado, Albert, additional, Pilatz, Adrian, additional, Pilmis, Benoit, additional, Pinazo, María-Jesús, additional, Pletz, Mathias W., additional, Pogue, Jason M., additional, Polgreen, Evelyn L., additional, Polgreen, Philip M., additional, Posfay-Barbe, Klara M., additional, Powderly, William G., additional, Presti, Rachel, additional, Prod'hom, Guy, additional, Puolakkainen, Mirja, additional, Quinn, Thomas C., additional, Raoult, Didier, additional, Razonable, Raymund R., additional, Read, Robert C., additional, Redfield, Robert R., additional, Rentenaar, Rob J., additional, Reynolds, Steven J., additional, Ribi, Camillo, additional, Richardson, Malcolm D., additional, Ritter, Michele L., additional, Roch, Antoine, additional, Rockstroh, Jürgen Kurt, additional, Rojek, Amanda, additional, Romero, José R., additional, Rooijakkers, Suzan H.M., additional, Rosenbluth, Daniel, additional, Rosenzweig, Sergio D., additional, Rossolini, Gian Maria, additional, Rubinstein, Ethan, additional, Ryan, Greg, additional, Safren, Steven A., additional, Sahasrabuddhe, Vikrant V., additional, Saikku, Pekka A.I., additional, Sajadi, Mohammad M., additional, Salvaggio, Michelle R., additional, Santos, Carlos A.Q., additional, Satlin, Michael J., additional, Schaeffer, Anthony J., additional, Schimmer, Christoph, additional, Schooley, Robert T., additional, Schumacher, Richard F., additional, Sha, Beverly E., additional, Shapiro, Daniel S., additional, Sheehan, Gerard, additional, Shlaes, David M., additional, Shoham, Shmuel, additional, Simmons, Cameron P., additional, Simon, Dennis W., additional, Simon, Matthew S., additional, Simonsen, Kari A., additional, Slack, Mary P.E., additional, Smith, Tyrel T., additional, Sobel, Jack D., additional, Souli, Maria, additional, Sridhar, Shruti, additional, Steckelberg, James M., additional, Stevens, Dennis L., additional, Strah, Heather, additional, Sturm, A. Willem, additional, Sungkanuparph, Somnuek, additional, Tabrizi, Sarah J., additional, Tacconelli, Evelina, additional, Tan, Chen Sabrina, additional, Taplitz, Randy A., additional, Thomas, Guillemette, additional, Thomas, Lora D., additional, Thuny, Franck, additional, Thwaites, Guy, additional, Tissot, Frederic, additional, Tønjum, Tone, additional, Torriani, Francesca J., additional, Toso, Christian, additional, Tulkens, Paul M., additional, Tunkel, Allan R., additional, Turner, Claire E., additional, Ustianowski, Andrew P., additional, van Bambeke, Françoise, additional, van Crevel, Reinout, additional, van de Beek, Diederik, additional, van Delden, Christian, additional, van der Eerden, Menno M., additional, van der Meer, Jos W.M., additional, van der Poll, Tom, additional, van Ingen, Jakko, additional, van Putten, Jos, additional, Vaudaux, Bernard P., additional, Vermund, Sten H., additional, Viscidi, Raphael P., additional, Visvanathan, Kumar, additional, Visvesvara, Govinda S., additional, von Seidlein, Lorenz, additional, Wagenlehner, Florian M.E., additional, Wald, Anna, additional, Walsh, Thomas J., additional, Warhurst, David C., additional, Warnock, David W., additional, Warrell, David A., additional, Warrell, Mary J., additional, Warris, Adilia, additional, Watkins, Richard R., additional, Weatherall, David J., additional, Weber, Rainer, additional, Weidner, Wolfgang, additional, White, Jonathan R., additional, White, Peter J., additional, Whitehorn, James, additional, Whitley, Richard J., additional, Whitty, Christopher J.M., additional, Wiersinga, Willem Joost, additional, Wilcox, Mark H., additional, Williams, Thomas N., additional, Wilson, Cara C., additional, Wilson, Mary Elizabeth, additional, Wisplinghoff, Hilmar, additional, Wood, Robin, additional, Wunderink, Richard G., additional, Wyles, David, additional, Yang, Zhi-Tao, additional, Yoder, Jonathan S., additional, Zaidi, Najam A., additional, Zimmer, Andrea J., additional, Zuckerman, Jane N., additional, and Zumla, Alimuddin, additional

Published
2017
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29. High incidence of Chikungunya virus and frequency of viremic blood donations during epidemic, Puerto Rico, USA, 2014

Author

Simmons, Graham, Bres, Vanessa, Lu, Kai, Liss, Nathan M., Brambilla, Donald J., Ryff, Kyle R., Bruhn, Roberta, Velez, Edwin, Ocampo, Derrek, Linnen, Jeffrey M., Latoni, Gerardo, Petersen, Lyle R., Williamson, Phillip C., and Busch, Michael P.

Subjects
Chikungunya virus -- Genetic aspects -- Diagnosis, Nucleotide sequencing -- Methods, Immunoglobulins -- Identification and classification, DNA sequencing -- Methods, Blood donors -- Safety and security measures, Health
Abstract

Chikungunya virus (CHIKV), a mosquitoborne, positive-sense RNA virus of the family Togaviridae, causes an acute febrile illness and severe polyarthralgia that can persist for months or years in some patients [...]

Published
2016
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30. Projecting month of birth for at-risk infants after Zika virus disease outbreaks

Author

Reefhuis, Jennita, Gilboa, Suzanne M., Johansson, Michael A., Valencia, Diana, Simeone, Regina M., Hills, Susan L., Polen, Kara, Jamieson, Denise J., Petersen, Lyle R., and Honein, Margaret A.

Subjects
Medical research, Medicine, Experimental, Childbirth -- Research, Health
Abstract

In May 2015, the World Health Organization (WHO) reported an outbreak of Zika virus disease in Brazil (1). Zika virus is a single-stranded RNA virus spread primarily by Aedes aegypti [...]

Published
2016
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32. Birth Defects Among Fetuses and Infants of US Women With Evidence of Possible Zika Virus Infection During Pregnancy

Author

Honein, Margaret A., Dawson, April L., Petersen, Emily E., Jones, Abbey M., Lee, Ellen H., Yazdy, Mahsa M., Ahmad, Nina, Macdonald, Jennifer, Evert, Nicole, Bingham, Andrea, Ellington, Sascha R., Shapiro-Mendoza, Carrie K., Oduyebo, Titilope, Fine, Anne D., Brown, Catherine M., Sommer, Jamie N., Gupta, Jyoti, Cavicchia, Philip, Slavinski, Sally, White, Jennifer L., Owen, S. Michele, Petersen, Lyle R., Boyle, Coleen, Meaney-Delman, Dana, and Jamieson, Denise J.

Published
2017
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33. Assessment of arbovirus surveillance 13 years after introduction of west Nile virus, United States

Author

Hadler, James L., Patel, Dhara, Nasei, Roger S., Petersen, Lyle R., Hughes, James M., Bradley, Kristy, Etkind, Paul, Kan, Lilly, and Engel, Jeffrey

Subjects
Sentinel surveillance -- Methods, West Nile virus -- Distribution, Health
Abstract

Before 1999, there was no appropriated funding in the United States for arboviral surveillance, and many states had no arboviral surveillance systems (2). After the emergence of West Nile virus [...]

Published
2015
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34. Zika virus as a cause of birth defects: Were the teratogenic effects of Zika virus missed for decades?

Author

Gilbert, Rachel K., Petersen, Lyle R., Honein, Margaret A., Moore, Cynthia A., and Rasmussen, Sonja A.

Abstract

Zika virus (ZIKV) was identified as a teratogen in 2016 when an increase in severe microcephaly and other brain defects was observed in fetuses and newborns following outbreaks in French Polynesia (2013–2014) and Brazil (2015–2016) and among travelers to other countries experiencing outbreaks. Some have questioned why ZIKV was not recognized as a teratogen before these outbreaks: whether novel genetic changes in ZIKV had increased its teratogenicity or whether its association with birth defects had previously been undetected. Here we examine the evidence for these two possibilities. We describe evidence for specific mutations that arose before the French Polynesia outbreak that might have increased ZIKV teratogenicity. We also present information on children born with findings consistent with congenital Zika syndrome (CZS) as early as 2009 and epidemiological evidence that suggests increases in CZS‐type birth defects before 2013. We also explore reasons why a link between ZIKV and birth defects might have been missed, including issues with surveillance of ZIKV infections and of birth defects, challenges to ZIKV diagnostic testing, and the susceptibility of different populations to ZIKV infection at the time of pregnancy. Although it is not possible to prove definitively that ZIKV had teratogenic properties before 2013, several pieces of evidence support the hypothesis that its teratogenicity had been missed in the past. These findings emphasize the need for further investments in global surveillance for emerging infections and for birth defects so that infectious teratogens can be identified more expeditiously in the future. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Clinical and laboratory features of patients diagnosed with alpha‐gal syndrome—2010–2019.

Author

Binder, Alison M., Cherry‐Brown, Dena, Biggerstaff, Brad J., Jones, Emma S., Amelio, Claire L., Beard, Charles B., Petersen, Lyle R., Kersh, Gilbert J., Commins, Scott P., and Armstrong, Paige A.

Subjects
PATHOLOGICAL laboratories, SYMPTOMS, FOOD allergy, RACE, AGE of onset, TICK infestations, MILK allergy
Abstract

Background: Alpha‐gal syndrome (AGS) is an IgE‐mediated allergy to galactose‐alpha‐1,3‐galactose. Clinical presentation ranges from hives to anaphylaxis; episodes typically occur 2–6 h after exposure to alpha‐gal‐containing products. In the United States, lone star tick bites are associated with the development of AGS. To characterize features of AGS, we evaluated a cohort of patients presenting for care at the University of North Carolina, focusing on symptoms, severity, and identifying features unique to specific alpha‐gal‐containing product exposures. Methods: We performed a chart review and descriptive analysis of 100 randomly selected patients with AGS during 2010–2019. Results: Median age at onset was 53 years, 56% were female, 95% reported White race, 86% reported a history of tick bite, and 75% met the criteria for anaphylaxis based on the involvement of ≥2 organ systems. Those reporting dairy reactions were significantly less likely to report isolated mucocutaneous symptoms (3% vs. 24%; ratio [95% CI]: 0.1 [0.1, 0.3]) than those who tolerated dairy, and were more likely to report gastrointestinal symptoms (79% vs. 59%; ratio [95% CI]: 1.3 [0.7, 2.6]), although this difference was not statistically significant. Dairy‐tolerant patients demonstrated higher alpha‐gal sIgE titers (as a percentage of total IgE) than dairy‐reactive patients (GM 4.1 [95% CI: 2.7, 6.1] vs. GM 2.5 [95% CI: 1.3, 4.8], respectively; ratio −1.6 [95% CI: −1.0, 3.9]). Conclusion: While tick exposure is common in the southern United States, nearly all AGS patients reported a tick bite. Gastrointestinal symptoms were prominent among those reporting reactions to dairy. Anaphylaxis was common, underscoring the severity and need to raise awareness of AGS among patients and providers. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Reinfection with SARS-CoV-2 among previously infected healthcare personnel and first responders

Author

Akinbami, Lara J, Biggerstaff, Brad J, Chan, Philip A, McGibbon, Emily, Pathela, Preeti, and Petersen, Lyle R

Subjects
AcademicSubjects/MED00290, SARS-CoV-2, antibody, Reinfection, Major Article, Emergency Responders, COVID-19, Humans, Delivery of Health Care, first responders, healthcare personnel
Abstract

Background SARS-CoV-2 virus testing among first responders and healthcare personnel who participated in a May-August 2020 serosurvey which assessed spike protein antibodies (S1 region) provided an opportunity to assess reinfection. Methods Serology survey data were merged with virus testing results from Rhode Island (March 1, 2020-February 17, 2021) and New York City (March 10-December 14, 2020). Participants with a positive virus test ≥14 days before their serology test were included. Reinfection was defined as a second positive SARS-CoV-2 test result ≥90 days after the first positive test. The association between serostatus and reinfection was assessed with a proportional hazards model adjusting for demographics, exposures, and virus testing frequency. Results Among 1,572 previously infected persons, 40 (2.5%) were reinfected. Reinfection differed by serostatus: 8.4% among seronegative versus 1.9% among seropositive participants (p

Published
2021

43. Prolonged Detection of Zika Virus RNA in Pregnant Women

Author

Meaney-Delman, Dana, Oduyebo, Titilope, Polen, Kara N.D., White, Jennifer L., Bingham, Andrea M., Slavinski, Sally A., Heberlein-Larson, Lea, St. George, Kirsten, Rakeman, Jennifer L., Hills, Susan, Olson, Christine K., Adamski, Alys, Culver Barlow, Lauren, Lee, Ellen H., Likos, Anna M., Muñoz, Jorge L., Petersen, Emily E., Dufort, Elizabeth M., Dean, Amy B., Cortese, Margaret M., Santiago, Gilberto A., Bhatnagar, Julu, Powers, Ann M., Zaki, Sherif, Petersen, Lyle R., Jamieson, Denise J., and Honein, Margaret A.

Published
2016
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45. Zika Virus

Author

Petersen, Lyle R., Jamieson, Denise J., Powers, Ann M., and Honein, Margaret A.

Published
2016
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