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A woman in her 60s with IgG kappa plasma cell myeloma presented with a solitary erythematous nodule on her right breast, indicative of cutaneous involvement by MM. The diagnosis was confirmed through histopathological findings and immunohistochemistry, distinguishing it from other conditions like lymphomas. Treatment with talquetamab led to complete resolution of the lesions, highlighting the importance of recognizing cutaneous manifestations of systemic diseases for appropriate management. This case underscores the challenges in diagnosing and treating cutaneous involvement by MM, emphasizing the need for further research in this area. [Extracted from the article]

Neurolymphomatosis (NL) is a rare condition caused by the lymphomatous or leukemic infiltration of nerves and manifests as neuropathy. Most often, NL is associated with B-lineage non-Hodgkin lymphoma (NHL) and only infrequently occurs in conjunction with T- or NK-lineage NHL. Extranodal NK/T-cell lymphoma (ENKTL)-associated NL is exceedingly unusual, with only 9 cases described in the English language literature, in addition to our case. Diagnosis of NL is challenging, as the entity can mimic neuropathies of more common etiologies, and an adequate biopsy may be difficult to obtain. Timely diagnosis demands a high index of suspicion, especially for patients without a history of hematologic malignancy. We expand upon a unique case of NL exclusively involving cranial nerves and cauda equina nerve roots, as the initial manifestation of ENKTL, and contextualize our findings within the framework of previously reported NK/T-lineage NL cases. [ABSTRACT FROM AUTHOR]