Author: "Peters, Marjolein J." - Searchworks@Jio Institute Digital Library Search Results

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204 results on '"Peters, Marjolein J."'

1. An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

Author: Liu, Jun, Carnero-Montoro, Elena, van Dongen, Jenny, Lent, Samantha, Nedeljkovic, Ivana, Ligthart, Symen, Tsai, Pei-Chien, Martin, Tiphaine C, Mandaviya, Pooja R, Jansen, Rick, Peters, Marjolein J, Duijts, Liesbeth, Jaddoe, Vincent WV, Tiemeier, Henning, Felix, Janine F, Willemsen, Gonneke, de Geus, Eco JC, Chu, Audrey Y, Levy, Daniel, Hwang, Shih-Jen, Bressler, Jan, Gondalia, Rahul, Salfati, Elias L, Herder, Christian, Hidalgo, Bertha A, Tanaka, Toshiko, Moore, Ann Zenobia, Lemaitre, Rozenn N, Jhun, Min A, Smith, Jennifer A, Sotoodehnia, Nona, Bandinelli, Stefania, Ferrucci, Luigi, Arnett, Donna K, Grallert, Harald, Assimes, Themistocles L, Hou, Lifang, Baccarelli, Andrea, Whitsel, Eric A, van Dijk, Ko Willems, Amin, Najaf, Uitterlinden, André G, Sijbrands, Eric JG, Franco, Oscar H, Dehghan, Abbas, Spector, Tim D, Dupuis, Josée, Hivert, Marie-France, Rotter, Jerome I, Meigs, James B, Pankow, James S, van Meurs, Joyce BJ, Isaacs, Aaron, Boomsma, Dorret I, Bell, Jordana T, Demirkan, Ayşe, and van Duijn, Cornelia M
Subjects: Biological Sciences, Genetics, Nutrition, Diabetes, Human Genome, Obesity, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Adult, Aged, Aged, 80 and over, Computer Simulation, CpG Islands, DNA Methylation, Diabetes Mellitus, Type 2, Epigenesis, Genetic, Epigenomics, Female, Gene Expression Profiling, Gene Expression Regulation, Genome-Wide Association Study, Glucose, Homeostasis, Humans, Insulin, Male, Metabolic Networks and Pathways, Middle Aged, Polymorphism, Single Nucleotide, Young Adult
Abstract: Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pathology by a blood-based epigenome-wide association study of 4808 non-diabetic Europeans in the discovery phase and 11,750 individuals in the replication. We identify CpGs in LETM1, RBM20, IRS2, MAN2A2 and the 1q25.3 region associated with fasting insulin, and in FCRL6, SLAMF1, APOBEC3H and the 15q26.1 region with fasting glucose. In silico cross-omics analyses highlight the role of differential methylation in the crosstalk between the adaptive immune system and glucose homeostasis. The differential methylation explains at least 16.9% of the association between obesity and insulin. Our study sheds light on the biological interactions between genetic variants driving differential methylation and gene expression in the early pathogenesis of T2D.
Published: 2019

2. DNA methylation-based measures of biological age: meta-analysis predicting time to death

Author: Chen, Brian H, Marioni, Riccardo E, Colicino, Elena, Peters, Marjolein J, Ward-Caviness, Cavin K, Tsai, Pei-Chien, Roetker, Nicholas S, Just, Allan C, Demerath, Ellen W, Guan, Weihua, Bressler, Jan, Fornage, Myriam, Studenski, Stephanie, Vandiver, Amy R, Moore, Ann Zenobia, Tanaka, Toshiko, Kiel, Douglas P, Liang, Liming, Vokonas, Pantel, Schwartz, Joel, Lunetta, Kathryn L, Murabito, Joanne M, Bandinelli, Stefania, Hernandez, Dena G, Melzer, David, Nalls, Michael, Pilling, Luke C, Price, Timothy R, Singleton, Andrew B, Gieger, Christian, Holle, Rolf, Kretschmer, Anja, Kronenberg, Florian, Kunze, Sonja, Linseisen, Jakob, Meisinger, Christine, Rathmann, Wolfgang, Waldenberger, Melanie, Visscher, Peter M, Shah, Sonia, Wray, Naomi R, McRae, Allan F, Franco, Oscar H, Hofman, Albert, Uitterlinden, André G, Absher, Devin, Assimes, Themistocles, Levine, Morgan E, Lu, Ake T, Tsao, Philip S, Hou, Lifang, Manson, JoAnn E, Carty, Cara L, LaCroix, Andrea Z, Reiner, Alexander P, Spector, Tim D, Feinberg, Andrew P, Levy, Daniel, Baccarelli, Andrea, van Meurs, Joyce, Bell, Jordana T, Peters, Annette, Deary, Ian J, Pankow, James S, Ferrucci, Luigi, and Horvath, Steve
Subjects: Biological Sciences, Genetics, Clinical Research, Prevention, Good Health and Well Being, Aging, DNA Methylation, Epigenesis, Genetic, Female, Humans, Logistic Models, Male, Mortality, Racial Groups, Risk Factors, Survival Analysis, T-Lymphocyte Subsets, all-cause mortality, lifespan, epigenetics, epigenetic clock, DNA methylation, mortality, Biochemistry and cell biology, Clinical sciences
Abstract: Estimates of biological age based on DNA methylation patterns, often referred to as "epigenetic age", "DNAm age", have been shown to be robust biomarkers of age in humans. We previously demonstrated that independent of chronological age, epigenetic age assessed in blood predicted all-cause mortality in four human cohorts. Here, we expanded our original observation to 13 different cohorts for a total sample size of 13,089 individuals, including three racial/ethnic groups. In addition, we examined whether incorporating information on blood cell composition into the epigenetic age metrics improves their predictive power for mortality. All considered measures of epigenetic age acceleration were predictive of mortality (p≤8.2x10-9), independent of chronological age, even after adjusting for additional risk factors (p
Published: 2016

3. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

Author: Joubert, Bonnie R, Felix, Janine F, Yousefi, Paul, Bakulski, Kelly M, Just, Allan C, Breton, Carrie, Reese, Sarah E, Markunas, Christina A, Richmond, Rebecca C, Xu, Cheng-Jian, Küpers, Leanne K, Oh, Sam S, Hoyo, Cathrine, Gruzieva, Olena, Söderhäll, Cilla, Salas, Lucas A, Baïz, Nour, Zhang, Hongmei, Lepeule, Johanna, Ruiz, Carlos, Ligthart, Symen, Wang, Tianyuan, Taylor, Jack A, Duijts, Liesbeth, Sharp, Gemma C, Jankipersadsing, Soesma A, Nilsen, Roy M, Vaez, Ahmad, Fallin, M Daniele, Hu, Donglei, Litonjua, Augusto A, Fuemmeler, Bernard F, Huen, Karen, Kere, Juha, Kull, Inger, Munthe-Kaas, Monica Cheng, Gehring, Ulrike, Bustamante, Mariona, Saurel-Coubizolles, Marie José, Quraishi, Bilal M, Ren, Jie, Tost, Jörg, Gonzalez, Juan R, Peters, Marjolein J, Håberg, Siri E, Xu, Zongli, van Meurs, Joyce B, Gaunt, Tom R, Kerkhof, Marjan, Corpeleijn, Eva, Feinberg, Andrew P, Eng, Celeste, Baccarelli, Andrea A, Neelon, Sara E Benjamin, Bradman, Asa, Merid, Simon Kebede, Bergström, Anna, Herceg, Zdenko, Hernandez-Vargas, Hector, Brunekreef, Bert, Pinart, Mariona, Heude, Barbara, Ewart, Susan, Yao, Jin, Lemonnier, Nathanaël, Franco, Oscar H, Wu, Michael C, Hofman, Albert, McArdle, Wendy, Van der Vlies, Pieter, Falahi, Fahimeh, Gillman, Matthew W, Barcellos, Lisa F, Kumar, Ashish, Wickman, Magnus, Guerra, Stefano, Charles, Marie-Aline, Holloway, John, Auffray, Charles, Tiemeier, Henning W, Smith, George Davey, Postma, Dirkje, Hivert, Marie-France, Eskenazi, Brenda, Vrijheid, Martine, Arshad, Hasan, Antó, Josep M, Dehghan, Abbas, Karmaus, Wilfried, Annesi-Maesano, Isabella, Sunyer, Jordi, Ghantous, Akram, Pershagen, Göran, Holland, Nina, Murphy, Susan K, DeMeo, Dawn L, Burchard, Esteban G, Ladd-Acosta, Christine, Snieder, Harold, and Nystad, Wenche
Subjects: Genetics, Pediatric, Human Genome, Tobacco, Tobacco Smoke and Health, Prevention, Aetiology, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Respiratory, Reproductive health and childbirth, Good Health and Well Being, Asthma, Child, Child, Preschool, Chromosome Mapping, Cleft Lip, Cleft Palate, DNA Methylation, Epigenesis, Genetic, Female, Genetic Association Studies, Humans, Infant, Infant, Newborn, Pregnancy, Smoking, White People, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract: Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has potential lifelong consequences. The mechanisms are largely unknown, but epigenetics most likely plays a role. We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n = 6,685), the association between maternal smoking in pregnancy and newborn blood DNA methylation at over 450,000 CpG sites (CpGs) by using the Illumina 450K BeadChip. Over 6,000 CpGs were differentially methylated in relation to maternal smoking at genome-wide statistical significance (false discovery rate, 5%), including 2,965 CpGs corresponding to 2,017 genes not previously related to smoking and methylation in either newborns or adults. Several genes are relevant to diseases that can be caused by maternal smoking (e.g., orofacial clefts and asthma) or adult smoking (e.g., certain cancers). A number of differentially methylated CpGs were associated with gene expression. We observed enrichment in pathways and processes critical to development. In older children (5 cohorts, n = 3,187), 100% of CpGs gave at least nominal levels of significance, far more than expected by chance (p value < 2.2 × 10(-16)). Results were robust to different normalization methods used across studies and cell type adjustment. In this large scale meta-analysis of methylation data, we identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.
Published: 2016

4. The transcriptional landscape of age in human peripheral blood.

Author: Peters, Marjolein J, Joehanes, Roby, Pilling, Luke C, Schurmann, Claudia, Conneely, Karen N, Powell, Joseph, Reinmaa, Eva, Sutphin, George L, Zhernakova, Alexandra, Schramm, Katharina, Wilson, Yana A, Kobes, Sayuko, Tukiainen, Taru, NABEC/UKBEC Consortium, Ramos, Yolande F, Göring, Harald HH, Fornage, Myriam, Liu, Yongmei, Gharib, Sina A, Stranger, Barbara E, De Jager, Philip L, Aviv, Abraham, Levy, Daniel, Murabito, Joanne M, Munson, Peter J, Huan, Tianxiao, Hofman, Albert, Uitterlinden, André G, Rivadeneira, Fernando, van Rooij, Jeroen, Stolk, Lisette, Broer, Linda, Verbiest, Michael MPJ, Jhamai, Mila, Arp, Pascal, Metspalu, Andres, Tserel, Liina, Milani, Lili, Samani, Nilesh J, Peterson, Pärt, Kasela, Silva, Codd, Veryan, Peters, Annette, Ward-Caviness, Cavin K, Herder, Christian, Waldenberger, Melanie, Roden, Michael, Singmann, Paula, Zeilinger, Sonja, Illig, Thomas, Homuth, Georg, Grabe, Hans-Jörgen, Völzke, Henry, Steil, Leif, Kocher, Thomas, Murray, Anna, Melzer, David, Yaghootkar, Hanieh, Bandinelli, Stefania, Moses, Eric K, Kent, Jack W, Curran, Joanne E, Johnson, Matthew P, Williams-Blangero, Sarah, Westra, Harm-Jan, McRae, Allan F, Smith, Jennifer A, Kardia, Sharon LR, Hovatta, Iiris, Perola, Markus, Ripatti, Samuli, Salomaa, Veikko, Henders, Anjali K, Martin, Nicholas G, Smith, Alicia K, Mehta, Divya, Binder, Elisabeth B, Nylocks, K Maria, Kennedy, Elizabeth M, Klengel, Torsten, Ding, Jingzhong, Suchy-Dicey, Astrid M, Enquobahrie, Daniel A, Brody, Jennifer, Rotter, Jerome I, Chen, Yii-Der I, Houwing-Duistermaat, Jeanine, Kloppenburg, Margreet, Slagboom, P Eline, Helmer, Quinta, den Hollander, Wouter, Bean, Shannon, Raj, Towfique, Bakhshi, Noman, Wang, Qiao Ping, Oyston, Lisa J, Psaty, Bruce M, Tracy, Russell P, Montgomery, Grant W, and Turner, Stephen T
Subjects: NABEC/UKBEC Consortium, Humans, Gene Expression Profiling, DNA Methylation, Aging, European Continental Ancestry Group, Transcriptome, Biomarkers
Abstract: Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the 'transcriptomic age' of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts.
Published: 2015

5. A meta-analysis of gene expression signatures of blood pressure and hypertension.

Author: Huan, Tianxiao, Esko, Tõnu, Peters, Marjolein J, Pilling, Luke C, Schramm, Katharina, Schurmann, Claudia, Chen, Brian H, Liu, Chunyu, Joehanes, Roby, Johnson, Andrew D, Yao, Chen, Ying, Sai-Xia, Courchesne, Paul, Milani, Lili, Raghavachari, Nalini, Wang, Richard, Liu, Poching, Reinmaa, Eva, Dehghan, Abbas, Hofman, Albert, Uitterlinden, André G, Hernandez, Dena G, Bandinelli, Stefania, Singleton, Andrew, Melzer, David, Metspalu, Andres, Carstensen, Maren, Grallert, Harald, Herder, Christian, Meitinger, Thomas, Peters, Annette, Roden, Michael, Waldenberger, Melanie, Dörr, Marcus, Felix, Stephan B, Zeller, Tanja, International Consortium for Blood Pressure GWAS (ICBP), Vasan, Ramachandran, O'Donnell, Christopher J, Munson, Peter J, Yang, Xia, Prokisch, Holger, Völker, Uwe, van Meurs, Joyce BJ, Ferrucci, Luigi, and Levy, Daniel
Subjects: International Consortium for Blood Pressure GWAS, Humans, Hypertension, Genetic Predisposition to Disease, Gene Expression Regulation, Blood Pressure, Genotype, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Transcriptome, Cardiovascular, Aging, Genetics, Prevention, Human Genome, Biotechnology, 2.1 Biological and endogenous factors, Developmental Biology
Abstract: Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or gene expression, which in turn affect BP variability. Therefore, characterizing genes whose expression is associated with BP may reveal cellular processes involved in BP regulation and uncover how transcripts mediate genetic and environmental effects on BP variability. A meta-analysis of results from six studies of global gene expression profiles of BP and hypertension in whole blood was performed in 7017 individuals who were not receiving antihypertensive drug treatment. We identified 34 genes that were differentially expressed in relation to BP (Bonferroni-corrected p
Published: 2015

6. New genetic loci link adipose and insulin biology to body fat distribution

Author: Shungin, Dmitry, Winkler, Thomas W, Croteau-Chonka, Damien C, Ferreira, Teresa, Locke, Adam E, Mägi, Reedik, Strawbridge, Rona J, Pers, Tune H, Fischer, Krista, Justice, Anne E, Workalemahu, Tsegaselassie, Wu, Joseph MW, Buchkovich, Martin L, Heard-Costa, Nancy L, Roman, Tamara S, Drong, Alexander W, Song, Ci, Gustafsson, Stefan, Day, Felix R, Esko, Tonu, Fall, Tove, Kutalik, Zoltán, Luan, Jian’an, Randall, Joshua C, Scherag, André, Vedantam, Sailaja, Wood, Andrew R, Chen, Jin, Fehrmann, Rudolf, Karjalainen, Juha, Kahali, Bratati, Liu, Ching-Ti, Schmidt, Ellen M, Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bragg-Gresham, Jennifer L, Buyske, Steven, Demirkan, Ayse, Ehret, Georg B, Feitosa, Mary F, Goel, Anuj, Jackson, Anne U, Johnson, Toby, Kleber, Marcus E, Kristiansson, Kati, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Palmer, Cameron D, Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J, Prokopenko, Inga, Stančáková, Alena, Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Van Vliet-Ostaptchouk, Jana V, Yengo, Loïc, Zhang, Weihua, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M, Bandinelli, Stefania, Barrett, Amy, Bellis, Claire, Bennett, Amanda J, Berne, Christian, Blüher, Matthias, Böhringer, Stefan, Bonnet, Fabrice, Böttcher, Yvonne, Bruinenberg, Marcel, Carba, Delia B, Caspersen, Ida H, Clarke, Robert, Warwick Daw, E, Deelen, Joris, Deelman, Ewa, Delgado, Graciela, Doney, Alex SF, Eklund, Niina, Erdos, Michael R, Estrada, Karol, Eury, Elodie, Friedrich, Nele, Garcia, Melissa E, Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S, Golay, Alain, Grallert, Harald, Grammer, Tanja B, Gräßler, Jürgen, Grewal, Jagvir, Groves, Christopher J, Haller, Toomas, and Hallmans, Goran
Subjects: Genetics, Human Genome, Diabetes, Obesity, Nutrition, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Cardiovascular, Stroke, Adipocytes, Adipogenesis, Adipose Tissue, Age Factors, Body Fat Distribution, Body Mass Index, Epigenesis, Genetic, Europe, Female, Genome, Human, Genome-Wide Association Study, Humans, Insulin, Insulin Resistance, Male, Models, Biological, Neovascularization, Physiologic, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Racial Groups, Sex Characteristics, Transcription, Genetic, Waist-Hip Ratio, ADIPOGen Consortium, CARDIOGRAMplusC4D Consortium, CKDGen Consortium, GEFOS Consortium, GENIE Consortium, GLGC, ICBP, International Endogene Consortium, LifeLines Cohort Study, MAGIC Investigators, MuTHER Consortium, PAGE Consortium, ReproGen Consortium, General Science & Technology
Abstract: Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P
Published: 2015

7. Genetic studies of body mass index yield new insights for obesity biology

Author: Locke, Adam E, Kahali, Bratati, Berndt, Sonja I, Justice, Anne E, Pers, Tune H, Day, Felix R, Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L, Yang, Jian, Croteau-Chonka, Damien C, Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltán, Luan, Jian’an, Mägi, Reedik, Randall, Joshua C, Winkler, Thomas W, Wood, Andrew R, Workalemahu, Tsegaselassie, Faul, Jessica D, Smith, Jennifer A, Hua Zhao, Jing, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Åsa K, Karjalainen, Juha, Schmidt, Ellen M, Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bolton, Jennifer L, Bragg-Gresham, Jennifer L, Buyske, Steven, Demirkan, Ayse, Deng, Guohong, Ehret, Georg B, Feenstra, Bjarke, Feitosa, Mary F, Fischer, Krista, Goel, Anuj, Gong, Jian, Jackson, Anne U, Kanoni, Stavroula, Kleber, Marcus E, Kristiansson, Kati, Lim, Unhee, Lotay, Vaneet, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Medland, Sarah E, Nalls, Michael A, Palmer, Cameron D, Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J, Prokopenko, Inga, Shungin, Dmitry, Stančáková, Alena, Strawbridge, Rona J, Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W, van Setten, Jessica, Van Vliet-Ostaptchouk, Jana V, Wang, Zhaoming, Yengo, Loïc, Zhang, Weihua, Isaacs, Aaron, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M, Attwood, Antony P, Bandinelli, Stefania, Barrett, Amy, Bas, Isabelita N, Bellis, Claire, Bennett, Amanda J, Berne, Christian, Blagieva, Roza, Blüher, Matthias, Böhringer, Stefan, Bonnycastle, Lori L, Böttcher, Yvonne, Boyd, Heather A, Bruinenberg, Marcel, Caspersen, Ida H, Ida Chen, Yii-Der, Clarke, Robert, Warwick Daw, E, de Craen, Anton JM, Delgado, Graciela, and Dimitriou, Maria
Subjects: Epidemiology, Biological Sciences, Health Sciences, Genetics, Human Genome, Nutrition, Obesity, Prevention, Aetiology, 2.1 Biological and endogenous factors, Stroke, Cardiovascular, Metabolic and endocrine, Oral and gastrointestinal, Cancer, Adipogenesis, Adiposity, Age Factors, Body Mass Index, Energy Metabolism, Europe, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Glutamic Acid, Humans, Insulin, Insulin Secretion, Male, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Racial Groups, Synapses, LifeLines Cohort Study, ADIPOGen Consortium, AGEN-BMI Working Group, CARDIOGRAMplusC4D Consortium, CKDGen Consortium, GLGC, ICBP, MAGIC Investigators, MuTHER Consortium, MIGen Consortium, PAGE Consortium, ReproGen Consortium, GENIE Consortium, International Endogene Consortium, General Science & Technology
Abstract: Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
Published: 2015

8. Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.

Author: Wessel, Jennifer, Chu, Audrey Y, Willems, Sara M, Wang, Shuai, Yaghootkar, Hanieh, Brody, Jennifer A, Dauriz, Marco, Hivert, Marie-France, Raghavan, Sridharan, Lipovich, Leonard, Hidalgo, Bertha, Fox, Keolu, Huffman, Jennifer E, An, Ping, Lu, Yingchang, Rasmussen-Torvik, Laura J, Grarup, Niels, Ehm, Margaret G, Li, Li, Baldridge, Abigail S, Stančáková, Alena, Abrol, Ravinder, Besse, Céline, Boland, Anne, Bork-Jensen, Jette, Fornage, Myriam, Freitag, Daniel F, Garcia, Melissa E, Guo, Xiuqing, Hara, Kazuo, Isaacs, Aaron, Jakobsdottir, Johanna, Lange, Leslie A, Layton, Jill C, Li, Man, Hua Zhao, Jing, Meidtner, Karina, Morrison, Alanna C, Nalls, Mike A, Peters, Marjolein J, Sabater-Lleal, Maria, Schurmann, Claudia, Silveira, Angela, Smith, Albert V, Southam, Lorraine, Stoiber, Marcus H, Strawbridge, Rona J, Taylor, Kent D, Varga, Tibor V, Allin, Kristine H, Amin, Najaf, Aponte, Jennifer L, Aung, Tin, Barbieri, Caterina, Bihlmeyer, Nathan A, Boehnke, Michael, Bombieri, Cristina, Bowden, Donald W, Burns, Sean M, Chen, Yuning, Chen, Yii-DerI, Cheng, Ching-Yu, Correa, Adolfo, Czajkowski, Jacek, Dehghan, Abbas, Ehret, Georg B, Eiriksdottir, Gudny, Escher, Stefan A, Farmaki, Aliki-Eleni, Frånberg, Mattias, Gambaro, Giovanni, Giulianini, Franco, Goddard, William A, Goel, Anuj, Gottesman, Omri, Grove, Megan L, Gustafsson, Stefan, Hai, Yang, Hallmans, Göran, Heo, Jiyoung, Hoffmann, Per, Ikram, Mohammad K, Jensen, Richard A, Jørgensen, Marit E, Jørgensen, Torben, Karaleftheri, Maria, Khor, Chiea C, Kirkpatrick, Andrea, Kraja, Aldi T, Kuusisto, Johanna, Lange, Ethan M, Lee, IT, Lee, Wen-Jane, Leong, Aaron, Liao, Jiemin, Liu, Chunyu, Liu, Yongmei, Lindgren, Cecilia M, Linneberg, Allan, and Malerba, Giovanni
Subjects: EPIC-InterAct Consortium, Humans, Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, Insulin, Glucose-6-Phosphatase, Blood Glucose, Oligonucleotide Array Sequence Analysis, Fasting, Polymorphism, Single Nucleotide, African Continental Ancestry Group, European Continental Ancestry Group, Genetic Variation, Genetic Loci, Genetic Association Studies, Mutation Rate, Exome, Glucagon-Like Peptide-1 Receptor, Diabetes Mellitus, Type 2, Polymorphism, Single Nucleotide, Diabetes, Genetics, Nutrition, Clinical Research, Prevention, Human Genome, 2.1 Biological and endogenous factors, Metabolic and Endocrine
Abstract: Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of a low-frequency nonsynonymous SNV in GLP1R (A316T; rs10305492; MAF=1.4%) with lower FG (β=-0.09±0.01 mmol l(-1), P=3.4 × 10(-12)), T2D risk (OR[95%CI]=0.86[0.76-0.96], P=0.010), early insulin secretion (β=-0.07±0.035 pmolinsulin mmolglucose(-1), P=0.048), but higher 2-h glucose (β=0.16±0.05 mmol l(-1), P=4.3 × 10(-4)). We identify a gene-based association with FG at G6PC2 (pSKAT=6.8 × 10(-6)) driven by four rare protein-coding SNVs (H177Y, Y207S, R283X and S324P). We identify rs651007 (MAF=20%) in the first intron of ABO at the putative promoter of an antisense lncRNA, associating with higher FG (β=0.02±0.004 mmol l(-1), P=1.3 × 10(-8)). Our approach identifies novel coding variant associations and extends the allelic spectrum of variation underlying diabetes-related quantitative traits and T2D susceptibility.
Published: 2015

9. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Author: Speliotes, Elizabeth K, Willer, Cristen J, Berndt, Sonja I, Monda, Keri L, Thorleifsson, Gudmar, Jackson, Anne U, Allen, Hana Lango, Lindgren, Cecilia M, Luan, Jian'an, Mägi, Reedik, Randall, Joshua C, Vedantam, Sailaja, Winkler, Thomas W, Qi, Lu, Workalemahu, Tsegaselassie, Heid, Iris M, Steinthorsdottir, Valgerdur, Stringham, Heather M, Weedon, Michael N, Wheeler, Eleanor, Wood, Andrew R, Ferreira, Teresa, Weyant, Robert J, Segrè, Ayellet V, Estrada, Karol, Liang, Liming, Nemesh, James, Park, Ju-Hyun, Gustafsson, Stefan, Kilpeläinen, Tuomas O, Yang, Jian, Bouatia-Naji, Nabila, Esko, Tõnu, Feitosa, Mary F, Kutalik, Zoltán, Mangino, Massimo, Raychaudhuri, Soumya, Scherag, Andre, Smith, Albert Vernon, Welch, Ryan, Zhao, Jing Hua, Aben, Katja K, Absher, Devin M, Amin, Najaf, Dixon, Anna L, Fisher, Eva, Glazer, Nicole L, Goddard, Michael E, Heard-Costa, Nancy L, Hoesel, Volker, Hottenga, Jouke-Jan, Johansson, Åsa, Johnson, Toby, Ketkar, Shamika, Lamina, Claudia, Li, Shengxu, Moffatt, Miriam F, Myers, Richard H, Narisu, Narisu, Perry, John RB, Peters, Marjolein J, Preuss, Michael, Ripatti, Samuli, Rivadeneira, Fernando, Sandholt, Camilla, Scott, Laura J, Timpson, Nicholas J, Tyrer, Jonathan P, van Wingerden, Sophie, Watanabe, Richard M, White, Charles C, Wiklund, Fredrik, Barlassina, Christina, Chasman, Daniel I, Cooper, Matthew N, Jansson, John-Olov, Lawrence, Robert W, Pellikka, Niina, Prokopenko, Inga, Shi, Jianxin, Thiering, Elisabeth, Alavere, Helene, Alibrandi, Maria TS, Almgren, Peter, Arnold, Alice M, Aspelund, Thor, Atwood, Larry D, Balkau, Beverley, Balmforth, Anthony J, Bennett, Amanda J, Ben-Shlomo, Yoav, Bergman, Richard N, Bergmann, Sven, Biebermann, Heike, Blakemore, Alexandra IF, Boes, Tanja, Bonnycastle, Lori L, Bornstein, Stefan R, Brown, Morris J, and Buchanan, Thomas A
Subjects: Biological Sciences, Genetics, Prevention, Human Genome, Body Height, Body Mass Index, Body Size, Body Weight, Chromosome Mapping, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Obesity, Polymorphism, Single Nucleotide, White People, MAGIC, Procardis Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract: Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
Published: 2010

10. A systematic analysis highlights multiple long non-coding RNAs associated with cardiometabolic disorders

Author: Ghanbari, Mohsen, Peters, Marjolein J., de Vries, Paul S., Boer, Cindy G., van Rooij, Jeroen G. J., Lee, Yu-Chi, Kumar, Vinod, Uitterlinden, André G., Ikram, M. Arfan, Wijmenga, Cisca, Ordovas, Jose M., Smith, Caren E., van Meurs, Joyce B. J., Erkeland, Stefan J., Franco, Oscar H., and Dehghan, Abbas
Published: 2018
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11. Tobacco smoking is associated with DNA methylation of diabetes susceptibility genes

Author: Ligthart, Symen, Steenaard, Rebecca V., Peters, Marjolein J., van Meurs, Joyce B. J., Sijbrands, Eric J. G., Uitterlinden, André G., Bonder, Marc J., Hofman, Albert, Franco, Oscar H., Dehghan, Abbas, and BIOS consortium
Published: 2016
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12. Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

Author: Betancourt, Martha C. Castaño, Cailotto, Frederic, Kerkhof, Hanneke J., Cornelis, Frederique M. F., Doherty, Sally A., Hart, Deborah J., Hofman, Albert, Luyten, Frank P., Maciewicz, Rose A., Mangino, Massimo, Metrustry, Sarah, Muir, Kenneth, Peters, Marjolein J., Rivadeneira, Fernando, Wheeler, Maggie, Zhang, Weiya, Arden, Nigel, Spector, Tim D., Uitterlinden, Andre G., Doherty, Michael, Lories, Rik J. U., Valdes, Ana M., and van Meurs, Joyce B. J.
Published: 2012

13. Genome-wide association analysis identifies six new loci associated with forced vital capacity

Author: Loth, Daan W, Artigas, María Soler, Gharib, Sina A, Wain, Louise V, Franceschini, Nora, Koch, Beate, Pottinger, Tess D, Smith, Albert Vernon, Duan, Qing, Oldmeadow, Chris, Lee, Mi Kyeong, Strachan, David P, James, Alan L, Huffman, Jennifer E, Vitart, Veronique, Ramasamy, Adaikalavan, Wareham, Nicholas J, Kaprio, Jaakko, Wang, Xin-Qun, Trochet, Holly, Kähönen, Mika, Flexeder, Claudia, Albrecht, Eva, Lopez, Lorna M, de Jong, Kim, Thyagarajan, Bharat, Alves, Alexessander Couto, Enroth, Stefan, Omenaas, Ernst, Joshi, Peter K, Fall, Tove, Viñuela, Ana, Launer, Lenore J, Loehr, Laura R, Fornage, Myriam, Li, Guo, Wilk, Jemma B, Tang, Wenbo, Manichaikul, Ani, Lahousse, Lies, Harris, Tamara B, North, Kari E, Rudnicka, Alicja R, Hui, Jennie, Gu, Xiangjun, Lumley, Thomas, Wright, Alan F, Hastie, Nicholas D, Campbell, Susan, Kumar, Rajesh, Pin, Isabelle, Scott, Robert A, Pietiläinen, Kirsi H, Surakka, Ida, Liu, Yongmei, Holliday, Elizabeth G, Schulz, Holger, Heinrich, Joachim, Davies, Gail, Vonk, Judith M, Wojczynski, Mary, Pouta, Anneli, Johansson, Åsa, Wild, Sarah H, Ingelsson, Erik, Rivadeneira, Fernando, Völzke, Henry, Hysi, Pirro G, Eiriksdottir, Gudny, Morrison, Alanna C, Rotter, Jerome I, Gao, Wei, Postma, Dirkje S, White, Wendy B, Rich, Stephen S, Hofman, Albert, Aspelund, Thor, Couper, David, Smith, Lewis J, Psaty, Bruce M, Lohman, Kurt, Burchard, Esteban G, Uitterlinden, André G, Garcia, Melissa, Joubert, Bonnie R, McArdle, Wendy L, Musk, A Bill, Hansel, Nadia, Heckbert, Susan R, Zgaga, Lina, van Meurs, Joyce B J, Navarro, Pau, Rudan, Igor, Oh, Yeon-Mok, Redline, Susan, Jarvis, Deborah L, Zhao, Jing Hua, Rantanen, Taina, O'Connor, George T, Ripatti, Samuli, Scott, Rodney J, Karrasch, Stefan, Grallert, Harald, Gaddis, Nathan C, Starr, John M, Wijmenga, Cisca, Minster, Ryan L, Lederer, David J, Pekkanen, Juha, Gyllensten, Ulf, Campbell, Harry, Morris, Andrew P, Gläser, Sven, Hammond, Christopher J, Burkart, Kristin M, Beilby, John, Kritchevsky, Stephen B, Gudnason, Vilmundur, Hancock, Dana B, Williams, O Dale, Polasek, Ozren, Zemunik, Tatijana, Kolcic, Ivana, Petrini, Marcy F, Wjst, Matthias, Kim, Woo Jin, Porteous, David J, Scotland, Generation, Smith, Blair H, Viljanen, Anne, Heliövaara, Markku, Attia, John R, Sayers, Ian, Hampel, Regina, Gieger, Christian, Deary, Ian J, Boezen, H Marike, Newman, Anne, Jarvelin, Marjo-Riitta, Wilson, James F, Lind, Lars, Stricker, Bruno H, Teumer, Alexander, Spector, Timothy D, Melén, Erik, Peters, Marjolein J, Lange, Leslie A, Barr, R Graham, Bracke, Ken R, Verhamme, Fien M, Sung, Joohon, Hiemstra, Pieter S, Cassano, Patricia A, Sood, Akshay, Hayward, Caroline, Dupuis, Josée, Hall, Ian P, Brusselle, Guy G, Tobin, Martin D, and London, Stephanie J
Published: 2014
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14. A Genetic Variant in the Seed Region of miR-4513 Shows Pleiotropic Effects on Lipid and Glucose Homeostasis, Blood Pressure, and Coronary Artery Disease

Author: Ghanbari, Mohsen, de Vries, Paul S., de Looper, Hans, Peters, Marjolein J., Schurmann, Claudia, Yaghootkar, Hanieh, Dörr, Marcus, Frayling, Timothy M., Uitterlinden, Andre G., Hofman, Albert, van Meurs, Joyce B. J., Erkeland, Stefan J., Franco, Oscar H., and Dehghan, Abbas
Published: 2014
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15. A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus

Author: Oei, Ling, Hsu, Yi-Hsiang, Styrkarsdottir, Unnur, Eussen, Bert H, de Klein, Annelies, Peters, Marjolein J, Halldorsson, Bjarni, Liu, Ching-Ti, Alonso, Nerea, Kaptoge, Stephen K, Thorleifsson, Gudmar, Hallmans, Göran, Hocking, Lynne J, Husted, Lise Bjerre, Jameson, Karen A, Kruk, Marcin, Lewis, Joshua R, Patel, Millan S, Scollen, Serena, Svensson, Olle, Trompet, Stella, van Schoor, Natasja M, Zhu, Kun, Buckley, Brendan M, Cooper, Cyrus, Ford, Ian, Goltzman, David, González-Macías, Jesús, Langdahl, Bente Lomholt, Leslie, William D, Lips, Paul, Lorenc, Roman S, Olmos, José M, Pettersson-Kymmer, Ulrika, Reid, David M, Riancho, José A, Slagboom, P Eline, Garcia-Ibarbia, Carmen, Ingvarsson, Thorvaldur, Johannsdottir, Hrefna, Luben, Robert, Medina-Gómez, Carolina, Arp, Pascal, Nandakumar, Kannabiran, Palsson, Stefan Th, Sigurdsson, Gunnar, van Meurs, Joyce B J, Zhou, Yanhua, Hofman, Albert, Jukema, J Wouter, Pols, Huibert A P, Prince, Richard L, Cupples, L Adrienne, Marshall, Christian R, Pinto, Dalila, Sato, Daisuke, Scherer, Stephen W, Reeve, Jonathan, Thorsteinsdottir, Unnur, Karasik, David, Richards, J Brent, Stefansson, Kari, Uitterlinden, André G, Ralston, Stuart H, Ioannidis, John P A, Kiel, Douglas P, Rivadeneira, Fernando, and Estrada, Karol
Published: 2014
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16. Identification of Genetic Loci Associated With Helicobacter pylori Serologic Status

Author: Mayerle, Julia, den Hoed, Caroline M., Schurmann, Claudia, Stolk, Lisette, Homuth, Georg, Peters, Marjolein J., Capelle, Lisette G., Zimmermann, Kathrin, Rivadeneira, Fernando, Gruska, Sybille, Völzke, Henry, de Vries, Annemarie C., Völker, Uwe, Teumer, Alexander, van Meurs, Joyce B., Steinmetz, Ivo, Nauck, Matthias, Ernst, Florian, Weiss, Frank-Ulrich, Hofman, Albert, Zenker, Martin, Kroemer, Heyo K., Prokisch, Holger, Uitterlinden, Andre G., Lerch, Markus M., and Kuipers, Ernst
Published: 2013
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17. Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region

Author: Peters, Marjolein J, Broer, Linda, Willemen, Hanneke L D M, Eiriksdottir, Gudny, Hocking, Lynne J, Holliday, Kate L, Horan, Michael A, Meulenbelt, Ingrid, Neogi, Tuhina, Popham, Maria, Schmidt, Carsten O, Soni, Anushka, Valdes, Ana M, Amin, Najaf, Dennison, Elaine M, Eijkelkamp, Niels, Harris, Tamara B, Hart, Deborah J, Hofman, Albert, Huygen, Frank J P M, Jameson, Karen A, Jones, Gareth T, Launer, Lenore J, Kerkhof, Hanneke J M, de Kruijf, Marjolein, McBeth, John, Kloppenburg, Margreet, Ollier, William E, Oostra, Ben, Payton, Antony, Rivadeneira, Fernando, Smith, Blair H, Smith, Albert V, Stolk, Lisette, Teumer, Alexander, Thomson, Wendy, Uitterlinden, André G, Wang, Ke, van Wingerden, Sophie H, Arden, Nigel K, Cooper, Cyrus, Felson, David, Gudnason, Vilmundur, Macfarlane, Gary J, Pendleton, Neil, Slagboom, P Eline, Spector, Tim D, Völzke, Henry, Kavelaars, Annemieke, van Duijn, Cornelia M, Williams, Frances M K, and van Meurs, Joyce B J
Published: 2013
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18. Associations of carotid intima media thickness with gene expression in whole blood and genetically predicted gene expression across 48 tissues.

Author: Castaneda, Andy B, Petty, Lauren E, Scholz, Markus, Jansen, Rick, Weiss, Stefan, Zhang, Xiaoling, Schramm, Katharina, Beutner, Frank, Kirsten, Holger, Schminke, Ulf, Hwang, Shih-Jen, Marzi, Carola, Dhana, Klodian, Seldenrijk, Adrie, Krohn, Knut, Homuth, Georg, Wolf, Petra, Peters, Marjolein J, Dörr, Marcus, and Peters, Annette
Published: 2022
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19. Hundreds of variants clustered in genomic loci and biological pathways affect human height

Author: Lango Allen, Hana, Estrada, Karol, Lettre, Guillaume, Berndt, Sonja I., Weedon, Michael N., Rivadeneira, Fernando, Willer, Cristen J., Jackson, Anne U., Vedantam, Sailaja, Raychaudhuri, Soumya, Ferreira, Teresa, Wood, Andrew R., Weyant, Robert J., Segrè, Ayellet V., Speliotes, Elizabeth K., Wheeler, Eleanor, Soranzo, Nicole, Park, Ju-Hyun, Yang, Jian, Gudbjartsson, Daniel, Heard-Costa, Nancy L., Randall, Joshua C., Qi, Lu, Vernon Smith, Albert, Mägi, Reedik, Pastinen, Tomi, Liang, Liming, Heid, Iris M., Luan, Jian’an, Thorleifsson, Gudmar, Winkler, Thomas W., Goddard, Michael E., Sin Lo, Ken, Palmer, Cameron, Workalemahu, Tsegaselassie, Aulchenko, Yurii S., Johansson, Åsa, Carola Zillikens, M., Feitosa, Mary F., Esko, Tõnu, Johnson, Toby, Ketkar, Shamika, Kraft, Peter, Mangino, Massimo, Prokopenko, Inga, Absher, Devin, Albrecht, Eva, Ernst, Florian, Glazer, Nicole L., Hayward, Caroline, Hottenga, Jouke-Jan, Jacobs, Kevin B., Knowles, Joshua W., Kutalik, Zoltán, Monda, Keri L., Polasek, Ozren, Preuss, Michael, Rayner, Nigel W., Robertson, Neil R., Steinthorsdottir, Valgerdur, Tyrer, Jonathan P., Voight, Benjamin F., Wiklund, Fredrik, Xu, Jianfeng, Hua Zhao, Jing, Nyholt, Dale R., Pellikka, Niina, Perola, Markus, Perry, John R. B., Surakka, Ida, Tammesoo, Mari-Liis, Altmaier, Elizabeth L., Amin, Najaf, Aspelund, Thor, Bhangale, Tushar, Boucher, Gabrielle, Chasman, Daniel I., Chen, Constance, Coin, Lachlan, Cooper, Matthew N., Dixon, Anna L., Gibson, Quince, Grundberg, Elin, Hao, Ke, Juhani Junttila, M., Kaplan, Lee M., Kettunen, Johannes, König, Inke R., Kwan, Tony, Lawrence, Robert W., Levinson, Douglas F., Lorentzon, Mattias, McKnight, Barbara, Morris, Andrew P., Müller, Martina, Suh Ngwa, Julius, Purcell, Shaun, Rafelt, Suzanne, Salem, Rany M., Salvi, Erika, Sanna, Serena, Shi, Jianxin, Sovio, Ulla, Thompson, John R., Turchin, Michael C., Vandenput, Liesbeth, Verlaan, Dominique J., Vitart, Veronique, White, Charles C., Ziegler, Andreas, Almgren, Peter, Balmforth, Anthony J., Campbell, Harry, Citterio, Lorena, De Grandi, Alessandro, Dominiczak, Anna, Duan, Jubao, Elliott, Paul, Elosua, Roberto, Eriksson, Johan G., Freimer, Nelson B., Geus, Eco J. C., Glorioso, Nicola, Haiqing, Shen, Hartikainen, Anna-Liisa, Havulinna, Aki S., Hicks, Andrew A., Hui, Jennie, Igl, Wilmar, Illig, Thomas, Jula, Antti, Kajantie, Eero, Kilpeläinen, Tuomas O., Koiranen, Markku, Kolcic, Ivana, Koskinen, Seppo, Kovacs, Peter, Laitinen, Jaana, Liu, Jianjun, Lokki, Marja-Liisa, Marusic, Ana, Maschio, Andrea, Meitinger, Thomas, Mulas, Antonella, Paré, Guillaume, Parker, Alex N., Peden, John F., Petersmann, Astrid, Pichler, Irene, Pietiläinen, Kirsi H., Pouta, Anneli, Ridderstråle, Martin, Rotter, Jerome I., Sambrook, Jennifer G., Sanders, Alan R., Oliver Schmidt, Carsten, Sinisalo, Juha, Smit, Jan H., Stringham, Heather M., Bragi Walters, G., Widen, Elisabeth, Wild, Sarah H., Willemsen, Gonneke, Zagato, Laura, Zgaga, Lina, Zitting, Paavo, Alavere, Helene, Farrall, Martin, McArdle, Wendy L., Nelis, Mari, Peters, Marjolein J., Ripatti, Samuli, van Meurs, Joyce B. J., Aben, Katja K., Ardlie, Kristin G., Beckmann, Jacques S., Beilby, John P., Bergman, Richard N., Bergmann, Sven, Collins, Francis S., Cusi, Daniele, den Heijer, Martin, Eiriksdottir, Gudny, Gejman, Pablo V., Hall, Alistair S., Hamsten, Anders, Huikuri, Heikki V., Iribarren, Carlos, Kähönen, Mika, Kaprio, Jaakko, Kathiresan, Sekar, Kiemeney, Lambertus, Kocher, Thomas, Launer, Lenore J., Lehtimäki, Terho, Melander, Olle, Mosley, Tom H., Jr, Musk, Arthur W., Nieminen, Markku S., O’Donnell, Christopher J., Ohlsson, Claes, Oostra, Ben, Palmer, Lyle J., Raitakari, Olli, Ridker, Paul M., Rioux, John D., Rissanen, Aila, Rivolta, Carlo, Schunkert, Heribert, Shuldiner, Alan R., Siscovick, David S., Stumvoll, Michael, Tönjes, Anke, Tuomilehto, Jaakko, van Ommen, Gert-Jan, Viikari, Jorma, Heath, Andrew C., Martin, Nicholas G., Montgomery, Grant W., Province, Michael A., Kayser, Manfred, Arnold, Alice M., Atwood, Larry D., Boerwinkle, Eric, Chanock, Stephen J., Deloukas, Panos, Gieger, Christian, Grönberg, Henrik, Hall, Per, Hattersley, Andrew T., Hengstenberg, Christian, Hoffman, Wolfgang, Mark Lathrop, G., Salomaa, Veikko, Schreiber, Stefan, Uda, Manuela, Waterworth, Dawn, Wright, Alan F., Assimes, Themistocles L., Barroso, Inês, Hofman, Albert, Mohlke, Karen L., Boomsma, Dorret I., Caulfield, Mark J., Adrienne Cupples, L., Erdmann, Jeanette, Fox, Caroline S., Gudnason, Vilmundur, Gyllensten, Ulf, Harris, Tamara B., Hayes, Richard B., Jarvelin, Marjo-Riitta, Mooser, Vincent, Munroe, Patricia B., Ouwehand, Willem H., Penninx, Brenda W., Pramstaller, Peter P., Quertermous, Thomas, Rudan, Igor, Samani, Nilesh J., Spector, Timothy D., Völzke, Henry, Watkins, Hugh, Wilson, James F., Groop, Leif C., Haritunians, Talin, Hu, Frank B., Kaplan, Robert C., Metspalu, Andres, North, Kari E., Schlessinger, David, Wareham, Nicholas J., Hunter, David J., O’Connell, Jeffrey R., Strachan, David P., Wichmann, H.-Erich, Borecki, Ingrid B., van Duijn, Cornelia M., Schadt, Eric E., Thorsteinsdottir, Unnur, Peltonen, Leena, Uitterlinden, André G., Visscher, Peter M., Chatterjee, Nilanjan, Loos, Ruth J. F., Boehnke, Michael, McCarthy, Mark I., Ingelsson, Erik, Lindgren, Cecilia M., Abecasis, Gonçalo R., Stefansson, Kari, Frayling, Timothy M., and Hirschhorn, Joel N.
Published: 2010
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20. DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

Author: Ligthart, Symen, Marzi, Carola, Aslibekyan, Stella, Mendelson, Michael M, Conneely, Karen N, Tanaka, Toshiko, Colicino, Elena, Waite, Lindsay L, Joehanes, Roby, Guan, Weihua, Brody, Jennifer A, Elks, Cathy, Marioni, Riccardo, Jhun, Min A, Agha, Golareh, Bressler, Jan, Ward-Caviness, Cavin K, Chen, Brian H, Huan, Tianxiao, Bakulski, Kelly, Salfati, Elias L, WHI-EMPC Investigators, Fiorito, Giovanni, CHARGE epigenetics of Coronary Heart Disease, Wahl, Simone, Schramm, Katharina, Sha, Jin, Hernandez, Dena G, Just, Allan C, Smith, Jennifer A, Sotoodehnia, Nona, Pilling, Luke C, Pankow, James S, Tsao, Phil S, Liu, Chunyu, Zhao, Wei, Guarrera, Simonetta, Michopoulos, Vasiliki J, Smith, Alicia K, Peters, Marjolein J, Melzer, David, Vokonas, Pantel, Fornage, Myriam, Prokisch, Holger, Bis, Joshua C, Chu, Audrey Y, Herder, Christian, Grallert, Harald, Yao, Chen, Shah, Sonia, McRae, Allan F, Lin, Honghuang, Horvath, Steve, Fallin, Daniele, Hofman, Albert, Wareham, Nicholas J, Wiggins, Kerri L, Feinberg, Andrew P, Starr, John M, Visscher, Peter M, Murabito, Joanne M, Kardia, Sharon LR, Absher, Devin M, Binder, Elisabeth B, Singleton, Andrew B, Bandinelli, Stefania, Peters, Annette, Waldenberger, Melanie, Matullo, Giuseppe, Schwartz, Joel D, Demerath, Ellen W, Uitterlinden, André G, van Meurs, Joyce BJ, Franco, Oscar H, Chen, Yii-Der Ida, Levy, Daniel, Turner, Stephen T, Deary, Ian J, Ressler, Kerry J, Dupuis, Josée, Ferrucci, Luigi, Ong, Ken K, Assimes, Themistocles L, Boerwinkle, Eric, Koenig, Wolfgang, Arnett, Donna K, Baccarelli, Andrea A, Benjamin, Emelia J, Dehghan, Abbas, Wareham, Nicholas [0000-0003-1422-2993], Ong, Kenneth [0000-0003-4689-7530], and Apollo - University of Cambridge Repository
Subjects: Male, Inflammation, DNA methylation, Quantitative Trait Loci, Diabetes, Gene Expression, Genetic Variation, White People, Epigenesis, Genetic, C-reactive protein, Black or African American, Coronary heart disease, Epigenome-wide association study, Humans, CpG Islands, Female, Nucleotide Motifs, Body mass index, Genome-Wide Association Study
Abstract: Background: Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation.Results: We performed a meta-analysis of epigenome-wide association studies (EWAS) of serum C-reactive protein (CRP), which is a sensitive marker of low-grade inflammation, in a large European population (n = 8863) and trans-ethnic replication in African Americans (n = 4111). We found differential methylation at 218 CpG sites to be associated with CRP (P –7) in the discovery panel of European ancestry and replicated (P –4) 58 CpG sites (45 unique loci) among African Americans. To further characterize the molecular and clinical relevance of the findings, we examined the association with gene expression, genetic sequence variants, and clinical outcomes. DNA methylation at nine (16%) CpG sites was associated with whole blood gene expression in cis (P –5), ten (17%) CpG sites were associated with a nearby genetic variant (P –3), and 51 (88%) were also associated with at least one related cardiometabolic entity (P –5). An additive weighted score of replicated CpG sites accounted for up to 6% inter-individual variation (R2) of age-adjusted and sex-adjusted CRP, independent of known CRP-related genetic variants.Conclusion: We have completed an EWAS of chronic low-grade inflammation and identified many novel genetic loci underlying inflammation that may serve as targets for the development of novel therapeutic interventions for inflammation.
Published: 2016

21. Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

Author: Liu, Jun, primary, Carnero-Montoro, Elena, additional, van Dongen, Jenny, additional, Lent, Samantha, additional, Nedeljkovic, Ivana, additional, Ligthart, Symen, additional, Tsai, Pei-Chien, additional, Martin, Tiphaine C., additional, Mandaviya, Pooja R., additional, Jansen, Rick, additional, Peters, Marjolein J., additional, Duijts, Liesbeth, additional, Jaddoe, Vincent W.V., additional, Tiemeier, Henning, additional, Felix, Janine F., additional, Chu, Audrey Y., additional, Levy, Daniel, additional, Hwang, Shih-Jen, additional, Bressler, Jan, additional, Gondalia, Rahul, additional, Salfati, Elias L., additional, Herder, Christian, additional, Hidalgo, Bertha A., additional, Tanaka, Toshiko, additional, Moore, Ann Zenobia, additional, Lemaitre, Rozenn N., additional, Jhun, Min A., additional, Smith, Jennifer A., additional, Sotoodehnia, Nona, additional, Bandinelli, Stefania, additional, Ferrucci, Luigi, additional, Arnett, Donna K., additional, Grallert, Harald, additional, Assimes, Themistocles L., additional, Hou, Lifang, additional, Baccarelli, Andrea, additional, Whitsel, Eric A., additional, van Dijk, Ko Willems, additional, Amin, Najaf, additional, Uitterlinden, André G., additional, Sijbrands, Eric J.G., additional, Franco, Oscar H., additional, Dehghan, Abbas, additional, Spector, Tim D., additional, Dupuis, Josée, additional, Hivert, Marie-France, additional, Rotter, Jerome I., additional, Meigs, James B., additional, Pankow, James S., additional, van Meurs, Joyce B.J., additional, Isaacs, Aaron, additional, Boomsma, Dorret I., additional, Bell, Jordana T., additional, Demirkan, Ayşe, additional, and van Duijn, Cornelia M., additional
Published: 2018
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22. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

Author: dIRAS RA-2, Risk Assessment, Joubert, Bonnie R, Felix, Janine F, Yousefi, Paul, Bakulski, Kelly M, Just, Allan C, Breton, Carrie, Reese, Sarah E, Markunas, Christina A, Richmond, Rebecca C, Xu, Cheng-Jian, Küpers, Leanne K, Oh, Sam S, Hoyo, Cathrine, Gruzieva, Olena, Söderhäll, Cilla, Salas, Lucas A, Baïz, Nour, Zhang, Hongmei, Lepeule, Johanna, Ruiz, Carlos, Ligthart, Symen, Wang, Tianyuan, Taylor, Jack A, Duijts, Liesbeth, Sharp, Gemma C, Jankipersadsing, Soesma A, Nilsen, Roy M, Vaez, Ahmad, Fallin, M Daniele, Hu, Donglei, Litonjua, Augusto A, Fuemmeler, Bernard F, Huen, Karen, Kere, Juha, Kull, Inger, Munthe-Kaas, Monica Cheng, Gehring, Ulrike, Bustamante, Mariona, Saurel-Coubizolles, Marie José, Quraishi, Bilal M, Ren, Jie, Tost, Jörg, Gonzalez, Juan R, Peters, Marjolein J, Håberg, Siri E, Xu, Zongli, van Meurs, Joyce B, Gaunt, Tom R, Kerkhof, Marjan, Corpeleijn, Eva, Feinberg, Andrew P, Eng, Celeste, Baccarelli, Andrea A, Benjamin Neelon, Sara E, Bradman, Asa, Merid, Simon Kebede, Bergström, Anna, Herceg, Zdenko, Hernandez-Vargas, Hector, Brunekreef, Bert, Pinart, Mariona, Heude, Barbara, Ewart, Susan, Yao, Jin, Lemonnier, Nathanaël, Franco, Oscar H, Wu, Michael C, Hofman, Albert, McArdle, Wendy, Van der Vlies, Pieter, Falahi, Fahimeh, Gillman, Matthew W, Barcellos, Lisa F, Kumar, Ashish, Wickman, Magnus, Guerra, Stefano, Charles, Marie-Aline, Holloway, John, Auffray, Charles, Tiemeier, Henning W, Smith, George Davey, Postma, Dirkje, Hivert, Marie-France, Eskenazi, Brenda, Vrijheid, Martine, Arshad, Hasan, Antó, Josep M, Dehghan, Abbas, Karmaus, Wilfried, Annesi-Maesano, Isabella, Sunyer, Jordi, Ghantous, Akram, Pershagen, Göran, Holland, Nina, Murphy, Susan K, DeMeo, Dawn L, Burchard, Esteban G, Ladd-Acosta, Christine, Snieder, Harold, Nystad, Wenche, Koppelman, Gerard H, Relton, Caroline L, Jaddoe, Vincent W V, Wilcox, Allen, Melén, Erik, London, Stephanie J, dIRAS RA-2, Risk Assessment, Joubert, Bonnie R, Felix, Janine F, Yousefi, Paul, Bakulski, Kelly M, Just, Allan C, Breton, Carrie, Reese, Sarah E, Markunas, Christina A, Richmond, Rebecca C, Xu, Cheng-Jian, Küpers, Leanne K, Oh, Sam S, Hoyo, Cathrine, Gruzieva, Olena, Söderhäll, Cilla, Salas, Lucas A, Baïz, Nour, Zhang, Hongmei, Lepeule, Johanna, Ruiz, Carlos, Ligthart, Symen, Wang, Tianyuan, Taylor, Jack A, Duijts, Liesbeth, Sharp, Gemma C, Jankipersadsing, Soesma A, Nilsen, Roy M, Vaez, Ahmad, Fallin, M Daniele, Hu, Donglei, Litonjua, Augusto A, Fuemmeler, Bernard F, Huen, Karen, Kere, Juha, Kull, Inger, Munthe-Kaas, Monica Cheng, Gehring, Ulrike, Bustamante, Mariona, Saurel-Coubizolles, Marie José, Quraishi, Bilal M, Ren, Jie, Tost, Jörg, Gonzalez, Juan R, Peters, Marjolein J, Håberg, Siri E, Xu, Zongli, van Meurs, Joyce B, Gaunt, Tom R, Kerkhof, Marjan, Corpeleijn, Eva, Feinberg, Andrew P, Eng, Celeste, Baccarelli, Andrea A, Benjamin Neelon, Sara E, Bradman, Asa, Merid, Simon Kebede, Bergström, Anna, Herceg, Zdenko, Hernandez-Vargas, Hector, Brunekreef, Bert, Pinart, Mariona, Heude, Barbara, Ewart, Susan, Yao, Jin, Lemonnier, Nathanaël, Franco, Oscar H, Wu, Michael C, Hofman, Albert, McArdle, Wendy, Van der Vlies, Pieter, Falahi, Fahimeh, Gillman, Matthew W, Barcellos, Lisa F, Kumar, Ashish, Wickman, Magnus, Guerra, Stefano, Charles, Marie-Aline, Holloway, John, Auffray, Charles, Tiemeier, Henning W, Smith, George Davey, Postma, Dirkje, Hivert, Marie-France, Eskenazi, Brenda, Vrijheid, Martine, Arshad, Hasan, Antó, Josep M, Dehghan, Abbas, Karmaus, Wilfried, Annesi-Maesano, Isabella, Sunyer, Jordi, Ghantous, Akram, Pershagen, Göran, Holland, Nina, Murphy, Susan K, DeMeo, Dawn L, Burchard, Esteban G, Ladd-Acosta, Christine, Snieder, Harold, Nystad, Wenche, Koppelman, Gerard H, Relton, Caroline L, Jaddoe, Vincent W V, Wilcox, Allen, Melén, Erik, and London, Stephanie J
Published: 2016

23. Genome-wide association analysis identifies six new loci associated with forced vital capacity

Author: Hayward, Caroline, Verhamme, Fien M, London, Stephanie J, Tobin, Martin D, Viñuela, Ana, Lopez, Lorna M, Hammond, Christopher J, Enroth, Stefan, Peters, Marjolein J, Heinrich, Joachim, Barr, R Graham, Lange, Leslie A, Teumer, Alexander, Johansson, Åsa, Brusselle, Guy G, Spector, Timothy D, Dupuis, Josée, Sood, Akshay, Hall, Ian P, Hiemstra, Pieter S, Melén, Erik, Bracke, Ken R, Sung, Joohon, Cassano, Patricia A, and Rudan, Igor
Subjects: respiratory system, respiratory tract diseases
Abstract: Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10−8) with FVC in or near EFEMP1, BMP6, MIR-129-2/HSD17B12, PRDM11, WWOX, and KCNJ2. Two (GSTCD and PTCH1) loci previously associated with spirometric measures were related to FVC. Newly implicated regions were followed-up in samples of African American, Korean, Chinese, and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and pathogenesis of restrictive lung disease.
Published: 2014
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24. Blood RNA expression profiles undergo major changes during the seventh decade

Author: Gheorghe, Marius, primary, Schurmann, Claudia, additional, Peters, Marjolein J., additional, Uitterlinden, André G., additional, Hofman, Albert, additional, Biffar, Reiner, additional, Homuth, Georg, additional, Völker, Uwe, additional, van Meurs, Joyce BJ, additional, and Raz, Vered, additional
Published: 2016
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25. A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking

Author: Huan, Tianxiao, primary, Joehanes, Roby, additional, Schurmann, Claudia, additional, Schramm, Katharina, additional, Pilling, Luke C., additional, Peters, Marjolein J., additional, Mägi, Reedik, additional, DeMeo, Dawn, additional, O'Connor, George T, additional, Ferrucci, Luigi, additional, Teumer, Alexander, additional, Homuth, Georg, additional, Biffar, Reiner, additional, Völker, Uwe, additional, Herder, Christian, additional, Waldenberger, Melanie, additional, Peters, Annette, additional, Zeilinger, Sonja, additional, Metspalu, Andres, additional, Hofman, Albert, additional, Uitterlinden, André G., additional, Hernandez, Dena G., additional, Singleton, Andrew B., additional, Bandinelli, Stefania, additional, Munson, Peter J., additional, Lin, Honghuang, additional, Benjamin, Emelia J., additional, Esko, Tõnu, additional, Grabe, Hans J., additional, Prokisch, Holger, additional, van Meurs, Joyce B.J., additional, Melzer, David, additional, and Levy, Daniel, additional
Published: 2016
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26. Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns

Author: Joubert, Bonnie R., primary, den Dekker, Herman T., additional, Felix, Janine F., additional, Bohlin, Jon, additional, Ligthart, Symen, additional, Beckett, Emma, additional, Tiemeier, Henning, additional, van Meurs, Joyce B., additional, Uitterlinden, Andre G., additional, Hofman, Albert, additional, Håberg, Siri E., additional, Reese, Sarah E., additional, Peters, Marjolein J., additional, Kulle Andreassen, Bettina, additional, Steegers, Eric A. P., additional, Nilsen, Roy M., additional, Vollset, Stein E., additional, Midttun, Øivind, additional, Ueland, Per M., additional, Franco, Oscar H., additional, Dehghan, Abbas, additional, de Jongste, Johan C., additional, Wu, Michael C., additional, Wang, Tianyuan, additional, Peddada, Shyamal D., additional, Jaddoe, Vincent W. V., additional, Nystad, Wenche, additional, Duijts, Liesbeth, additional, and London, Stephanie J., additional
Published: 2016
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27. Associations between joint effusion in the knee and gene expression levels in the circulation: a meta-analysis

Author: Peters, Marjolein J., primary, Ramos, Yolande F.M., additional, den Hollander, Wouter, additional, Schiphof, Dieuwke, additional, Hofman, Albert, additional, Uitterlinden, André G., additional, Oei, Edwin H.G., additional, Slagboom, P. Eline, additional, Kloppenburg, Margreet, additional, Bloem, Johan L., additional, Bierma-Zeinstra, Sita M.A., additional, Meulenbelt, Ingrid, additional, and van Meurs, Joyce B.J., additional
Published: 2016
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28. Genetic studies of body mass index yield new insights for obesity biology

Author: Locke, Adam E., Kahali, Bratati, Berndt, Sonja I., Justice, Anne E., Pers, Tune H., Day, Felix R., Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L., Yang, Jian, Croteau-Chonka, Damien C., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltan, Luan, Jian'an, Maegi, Reedik, Randall, Joshua C., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Faul, Jessica D., Smith, Jennifer A., Zhao, Jing Hua, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Asa K., Karjalainen, Juha, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bolton, Jennifer L., Bragg-Gresham, L., Buyske, Steven, Demirkan, Ayse, Deng, Guohong, Ehret, Georg B., Feenstra, Bjarke, Feitosa, Mary F., Fischer, Krista, Goel, Anuj, Gong, Jian, Jackson, Anne U., Kanoni, Stavroula, Kleber, Marcus E., Kristiansson, Kati, Lim, Unhee, Lotay, Vaneet, Mangino, Massimo, Leach, Irene Mateo, Medina-Gomez, Carolina, Medland, Sarah E., Nalls, Michael A., Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Shungin, Dmitry, Stancakova, Alena, Strawbridge, Rona J., Sung, Yun Ju, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W., van Settee, Jessica, Van Vliet-Ostaptchouk, Jana V., Wang, Zhaoming, Yengo, Loic, Zhang, Weihua, Isaacs, Aaron, Albrecht, Eva, Arnlov, Johan, Arscott, Gillian M., Attwood, Antony P., Bandinelli, Stefania, Barrett, Amy, Bas, Isabelita N., Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blagieva, Roza, Blueher, Matthias, Bohringer, Stefan, Bonnycastle, Lori L., Boettcher, Yvonne, Boyd, Heather A., Bruinenberg, Marcel, Caspersen, Ida H., Chen, Yii-Der Ida, Clarke, Robert, Daw, E. Warwick, de Craen, Anton J. M., Delgado, Graciela, Dimitriou, Maria, Doney, Alex S. F., Eklund, Niina, Estrada, Karol, Eury, Elodie, Folkersen, Lasse, Fraser, Ross M., Garcia, Melissa E., Geller, Frank, Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Goodall, Alison H., Gordon, Scott D., Gorski, Mathias, Grabe, Hans-Joergen, Grallert, Harald, Grammer, Tanja B., Graessler, Jurgen, Gronberg, Henrik, Groves, Christopher J., Gusto, Gaeelle, Haessler, Jeffrey, Hall, Per, Haller, Toomas, Hallmans, Göran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heard-Costa, Nancy L., Helmer, Qinta, Hengstenberg, Christian, Holmen, Oddgeir, Hottenga, Jouke-Jan, James, Alan L., Jeff, Janina M., Johansson, Asa, Jolley, Jennifer, Juliusdottir, Thorhildur, Kinnunen, Leena, Koenig, Wolfgang, Koskenvuo, Markku, Kratzer, Wolfgang, Laitinen, Jaana, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindstrom, Jaana, Lo, Ken Sin, Lobbens, Stephane, Lorbeer, Roberto, Lu, Yingchang, Mach, Francois, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., McLachlan, Stela, Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Moayyeri, Alireza, Monda, Keri L., Morken, Mario A., Mulas, Antonella, Mueller, Gabriele, Mueller-Nurasyid, Martina, Musk, Arthur W., Nagaraja, Ramaiah, Noethen, Markus M., Nolte, Ilja M., Pilz, Stefan, Rayner, Nigel W., Renstrom, Frida, Rettig, Rainer, Ried, Janina S., Ripke, Stephan, Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Schumacher, Fredrick R., Scott, William R., Seufferlein, Thomas, Shi, Jianxin, Smith, Albert Vernon, Smolonska, Joanna, Stanton, Alice V., Steinthorsdottir, Valgerdur, Stirrups, Kathleen, Stringham, Heather M., Sundstrom, Johan, Swertz, Morris A., Swift, Amy J., Syvanen, Ann-Christine, Tan, Sian-Tsung, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tyrer, Jonathan P., Uh, Hae-Won, Vandenput, Liesbeth, Verhulst, Frank C., Vermeulen, Sita H., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Warren, Helen R., Waterworth, Dawn, Weedon, Michael N., Wilkens, Lynne R., Willenborg, Christina, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Wrightl, Alan F., Zhang, Qunyuan, Brennan, Eoin P., Choi, Murim, Dastani, Zari, Drong, Alexander W., Eriksson, Per, Franco-Cereceda, Anders, Gadin, Jesper R., Gharavi, Ali G., Goddard, Michael E., Handsaker, Robert E., Huang, Jinyan, Karpe, Fredrik, Kathiresan, Sekar, Keildson, Sarah, Kiryluk, Krzysztof, Kubo, Michiaki, Lee, Jong-Young, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McCarroll, Steven A., McKnight, Amy J., Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Okada, Yukinori, Perry, John R. B., Dorajoo, Rajkumar, Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Scott, Robert A., Stolk, Lisette, Takahashi, Atsushi, Tanaka, Toshihiro, van 't Hooft, Ferdinand M., Vinkhuyzen, Anna A. E., Westra, Harm-Jan, Zheng, Wei, Zondervan, Krina T., Heath, Andrew C., Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Bovet, Pascal, Campbell, Harry, Caulfield, Mark J., Cesana, Giancarlo, Chakravarti, Aravinda, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Crawford, Dana C., Cupples, L. Adrienne, Cusi, Daniele, Danesh, John, de Faire, Ulf, den Ruijter, Hester M., Dominiczak, Anna F., Erbel, Raimund, Erdmann, Jeanette, Eriksson, Johan G., Farrall, Martin, Felix, Stephan B., Ferrannini, Ele, Ferrieres, Jean, Ford, Ian, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gejman, Pablo V., Gieger, Christian, Gottesman, Omri, Gudnason, Vilmundur, Gyllensten, Ulf, Hall, Alistair S., Harris, Tamara B., Hattersley, Andrew T., Hicks, Andrew A., Hindorff, Lucia A., Hingorani, Aroon D., Hofman, Albert, Homuth, Georg, Hovingh, G. Kees, Humphries, Steve E., Hunt, Steven C., Hypponen, Elina, Illig, Thomas, Jacobs, Kevin B., Jarvelin, Marjo-Riitta, Joeckel, Karl-Heinz, Johansen, Berit, Jousilahti, Pekka, Jukema, J. Wouter, Jula, Antti M., Kaprio, Jaakko, Kastelein, John J. P., Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Knekt, Paul, Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Laic, Lehtimaki, Terho, Lyssenko, Valeriya, Mannisto, Satu, Marette, Andre, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Moll, Frans L., Morris, Andrew D., Morris, Andrew P., Murray, Jeffrey C., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Madden, Pamela A. F., Pasterkamp, Gerard, Peden, John F., Peters, Annette, Postma, Dirkje S., Pramstaller, Peter P., Price, Jackie F., Qi, Lu, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Rioux, John D., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramines, Jouko, Sarzynski, Mark A., Schunkert, Heribert, Schwarz, Peter E. H., Sever, Peter, Shuldiner, Alan R., Sinisalo, Juha, Stolk, Ronald P., Strauch, Konstantin, Toenjes, Anke, Tregouet, David-Alexandre, Tremblay, Angelo, Tremoli, Elena, Virtamo, Jarmo, Vohl, Marie-Claude, Voelker, Uwe, Waeber, Gerard, Willemsen, Gonneke, Witteman, Jacqueline C., Zillikens, M. Carola, Adair, Linda S., Amouyel, Philippe, Asselbergs, Folkert W., Assimes, Themistocles L., Bochud, Murielle, Boehm, Bernhard O., Boerwinkle, Eric, Bornstein, Stefan R., Bottinger, Erwin P., Bouchard, Claude, Cauchi, Stephane, Chambers, John C., Chanock, Stephen J., Cooper, Richard S., de Bakker, Paul I. W., Dedoussis, George, Ferrucci, Luigi, Franks, Paul W., Froguel, Philippe, Groop, Leif C., Haiman, Christopher A., Hamsten, Anders, Hui, Jennie, Hunter, David J., Hveem, Kristian, Kaplan, Robert C., Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, Martin, Nicholas G., Maerz, Winfried, Melbve, Mads, Metspalu, Andres, Moebus, Susanne, Munroe, Patricia B., Njolstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Perusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sattar, Naveed, Schadt, Eric E., Schlessinger, David, Slagboom, P. Eline, Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnu R., Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, Andre G., Uusitupa, Matti, van der Harst, Pim, Walker, Mark, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Weir, David R., Wichmann, H-Erich, Wilson, James F., Zanen, Pieter, Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Heid, Iris M., O'Connell, Jeffrey R., Strachan, David P., Stefansson, Kari, van Duijri, Cornelia M., Abecasis, Goncalo R., Franke, Lude, Frayling, Timothy M., McCarthy, Mark I., Visscher, Peter M., Scherag, Andre, Willer, Cristen J., Boehnke, Michael, Mohlke, Karen L., Lindgren, Cecilia M., Beckmann, Jacques S., Barroso, Ines, North, Kari E., Ingelsson, Erik, Hirschhorn, Joel N., Loos, Ruth J. F., Speliotes, Elizabeth K., Locke, Adam E., Kahali, Bratati, Berndt, Sonja I., Justice, Anne E., Pers, Tune H., Day, Felix R., Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L., Yang, Jian, Croteau-Chonka, Damien C., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltan, Luan, Jian'an, Maegi, Reedik, Randall, Joshua C., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Faul, Jessica D., Smith, Jennifer A., Zhao, Jing Hua, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Asa K., Karjalainen, Juha, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bolton, Jennifer L., Bragg-Gresham, L., Buyske, Steven, Demirkan, Ayse, Deng, Guohong, Ehret, Georg B., Feenstra, Bjarke, Feitosa, Mary F., Fischer, Krista, Goel, Anuj, Gong, Jian, Jackson, Anne U., Kanoni, Stavroula, Kleber, Marcus E., Kristiansson, Kati, Lim, Unhee, Lotay, Vaneet, Mangino, Massimo, Leach, Irene Mateo, Medina-Gomez, Carolina, Medland, Sarah E., Nalls, Michael A., Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Shungin, Dmitry, Stancakova, Alena, Strawbridge, Rona J., Sung, Yun Ju, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W., van Settee, Jessica, Van Vliet-Ostaptchouk, Jana V., Wang, Zhaoming, Yengo, Loic, Zhang, Weihua, Isaacs, Aaron, Albrecht, Eva, Arnlov, Johan, Arscott, Gillian M., Attwood, Antony P., Bandinelli, Stefania, Barrett, Amy, Bas, Isabelita N., Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blagieva, Roza, Blueher, Matthias, Bohringer, Stefan, Bonnycastle, Lori L., Boettcher, Yvonne, Boyd, Heather A., Bruinenberg, Marcel, Caspersen, Ida H., Chen, Yii-Der Ida, Clarke, Robert, Daw, E. Warwick, de Craen, Anton J. M., Delgado, Graciela, Dimitriou, Maria, Doney, Alex S. F., Eklund, Niina, Estrada, Karol, Eury, Elodie, Folkersen, Lasse, Fraser, Ross M., Garcia, Melissa E., Geller, Frank, Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Goodall, Alison H., Gordon, Scott D., Gorski, Mathias, Grabe, Hans-Joergen, Grallert, Harald, Grammer, Tanja B., Graessler, Jurgen, Gronberg, Henrik, Groves, Christopher J., Gusto, Gaeelle, Haessler, Jeffrey, Hall, Per, Haller, Toomas, Hallmans, Göran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heard-Costa, Nancy L., Helmer, Qinta, Hengstenberg, Christian, Holmen, Oddgeir, Hottenga, Jouke-Jan, James, Alan L., Jeff, Janina M., Johansson, Asa, Jolley, Jennifer, Juliusdottir, Thorhildur, Kinnunen, Leena, Koenig, Wolfgang, Koskenvuo, Markku, Kratzer, Wolfgang, Laitinen, Jaana, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindstrom, Jaana, Lo, Ken Sin, Lobbens, Stephane, Lorbeer, Roberto, Lu, Yingchang, Mach, Francois, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., McLachlan, Stela, Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Moayyeri, Alireza, Monda, Keri L., Morken, Mario A., Mulas, Antonella, Mueller, Gabriele, Mueller-Nurasyid, Martina, Musk, Arthur W., Nagaraja, Ramaiah, Noethen, Markus M., Nolte, Ilja M., Pilz, Stefan, Rayner, Nigel W., Renstrom, Frida, Rettig, Rainer, Ried, Janina S., Ripke, Stephan, Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Schumacher, Fredrick R., Scott, William R., Seufferlein, Thomas, Shi, Jianxin, Smith, Albert Vernon, Smolonska, Joanna, Stanton, Alice V., Steinthorsdottir, Valgerdur, Stirrups, Kathleen, Stringham, Heather M., Sundstrom, Johan, Swertz, Morris A., Swift, Amy J., Syvanen, Ann-Christine, Tan, Sian-Tsung, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tyrer, Jonathan P., Uh, Hae-Won, Vandenput, Liesbeth, Verhulst, Frank C., Vermeulen, Sita H., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Warren, Helen R., Waterworth, Dawn, Weedon, Michael N., Wilkens, Lynne R., Willenborg, Christina, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Wrightl, Alan F., Zhang, Qunyuan, Brennan, Eoin P., Choi, Murim, Dastani, Zari, Drong, Alexander W., Eriksson, Per, Franco-Cereceda, Anders, Gadin, Jesper R., Gharavi, Ali G., Goddard, Michael E., Handsaker, Robert E., Huang, Jinyan, Karpe, Fredrik, Kathiresan, Sekar, Keildson, Sarah, Kiryluk, Krzysztof, Kubo, Michiaki, Lee, Jong-Young, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McCarroll, Steven A., McKnight, Amy J., Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Okada, Yukinori, Perry, John R. B., Dorajoo, Rajkumar, Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Scott, Robert A., Stolk, Lisette, Takahashi, Atsushi, Tanaka, Toshihiro, van 't Hooft, Ferdinand M., Vinkhuyzen, Anna A. E., Westra, Harm-Jan, Zheng, Wei, Zondervan, Krina T., Heath, Andrew C., Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Bovet, Pascal, Campbell, Harry, Caulfield, Mark J., Cesana, Giancarlo, Chakravarti, Aravinda, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Crawford, Dana C., Cupples, L. Adrienne, Cusi, Daniele, Danesh, John, de Faire, Ulf, den Ruijter, Hester M., Dominiczak, Anna F., Erbel, Raimund, Erdmann, Jeanette, Eriksson, Johan G., Farrall, Martin, Felix, Stephan B., Ferrannini, Ele, Ferrieres, Jean, Ford, Ian, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gejman, Pablo V., Gieger, Christian, Gottesman, Omri, Gudnason, Vilmundur, Gyllensten, Ulf, Hall, Alistair S., Harris, Tamara B., Hattersley, Andrew T., Hicks, Andrew A., Hindorff, Lucia A., Hingorani, Aroon D., Hofman, Albert, Homuth, Georg, Hovingh, G. Kees, Humphries, Steve E., Hunt, Steven C., Hypponen, Elina, Illig, Thomas, Jacobs, Kevin B., Jarvelin, Marjo-Riitta, Joeckel, Karl-Heinz, Johansen, Berit, Jousilahti, Pekka, Jukema, J. Wouter, Jula, Antti M., Kaprio, Jaakko, Kastelein, John J. P., Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Knekt, Paul, Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Laic, Lehtimaki, Terho, Lyssenko, Valeriya, Mannisto, Satu, Marette, Andre, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Moll, Frans L., Morris, Andrew D., Morris, Andrew P., Murray, Jeffrey C., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Madden, Pamela A. F., Pasterkamp, Gerard, Peden, John F., Peters, Annette, Postma, Dirkje S., Pramstaller, Peter P., Price, Jackie F., Qi, Lu, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Rioux, John D., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramines, Jouko, Sarzynski, Mark A., Schunkert, Heribert, Schwarz, Peter E. H., Sever, Peter, Shuldiner, Alan R., Sinisalo, Juha, Stolk, Ronald P., Strauch, Konstantin, Toenjes, Anke, Tregouet, David-Alexandre, Tremblay, Angelo, Tremoli, Elena, Virtamo, Jarmo, Vohl, Marie-Claude, Voelker, Uwe, Waeber, Gerard, Willemsen, Gonneke, Witteman, Jacqueline C., Zillikens, M. Carola, Adair, Linda S., Amouyel, Philippe, Asselbergs, Folkert W., Assimes, Themistocles L., Bochud, Murielle, Boehm, Bernhard O., Boerwinkle, Eric, Bornstein, Stefan R., Bottinger, Erwin P., Bouchard, Claude, Cauchi, Stephane, Chambers, John C., Chanock, Stephen J., Cooper, Richard S., de Bakker, Paul I. W., Dedoussis, George, Ferrucci, Luigi, Franks, Paul W., Froguel, Philippe, Groop, Leif C., Haiman, Christopher A., Hamsten, Anders, Hui, Jennie, Hunter, David J., Hveem, Kristian, Kaplan, Robert C., Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, Martin, Nicholas G., Maerz, Winfried, Melbve, Mads, Metspalu, Andres, Moebus, Susanne, Munroe, Patricia B., Njolstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Perusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sattar, Naveed, Schadt, Eric E., Schlessinger, David, Slagboom, P. Eline, Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnu R., Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, Andre G., Uusitupa, Matti, van der Harst, Pim, Walker, Mark, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Weir, David R., Wichmann, H-Erich, Wilson, James F., Zanen, Pieter, Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Heid, Iris M., O'Connell, Jeffrey R., Strachan, David P., Stefansson, Kari, van Duijri, Cornelia M., Abecasis, Goncalo R., Franke, Lude, Frayling, Timothy M., McCarthy, Mark I., Visscher, Peter M., Scherag, Andre, Willer, Cristen J., Boehnke, Michael, Mohlke, Karen L., Lindgren, Cecilia M., Beckmann, Jacques S., Barroso, Ines, North, Kari E., Ingelsson, Erik, Hirschhorn, Joel N., Loos, Ruth J. F., and Speliotes, Elizabeth K.
Abstract: Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for similar to 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous systemin obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
Published: 2015
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29. New genetic loci link adipose and insulin biology to body fat distribution

Author: UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Shungin, Dmitry, Winkler, Thomas W., Croteau-Chonka, Damien C., Ferreira, Teresa, Locke, Adam E., Mägi, Reedik, Strawbridge, Rona J., Pers, Tune H., Fischer, Krista, Justice, Anne E., Workalemahu, Tsegaselassie, Wu, Joseph M. W., Buchkovich, Martin L., Heard-Costa, Nancy L., Roman, Tamara S., Drong, Alexander W., Song, Ci, Gustafsson, Stefan, Day, Felix R., Esko, Tonu, Fall, Tove, Kutalik, Zoltán, Luan, Jian’an, Randall, Joshua C., Scherag, André, Vedantam, Sailaja, Wood, Andrew R., Chen, Jin, Fehrmann, Rudolf, Karjalainen, Juha, Kahali, Bratati, Liu, Ching-Ti, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bragg-Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Ehret, Georg B., Feitosa, Mary F., Goel, Anuj, Jackson, Anne U., Johnson, Toby, Kleber, Marcus E., Kristiansson, Kati, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Stančáková, Alena, Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Van Vliet-Ostaptchouk, Jana V., Yengo, Loïc, Zhang, Weihua, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Bandinelli, Stefania, Barrett, Amy, Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blüher, Matthias, Böhringer, Stefan, Bonnet, Fabrice, Böttcher, Yvonne, Bruinenberg, Marcel, Carba, Delia B., Caspersen, Ida H., Clarke, Robert, Warwick Daw, E., Deelen, Joris, Deelman, Ewa, Delgado, Graciela, Doney, Alex S. F., Eklund, Niina, Erdos, Michael R., Estrada, Karol, Eury, Elodie, Friedrich, Nele, Garcia, Melissa E., Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Grallert, Harald, Grammer, Tanja B., Gräßler, Jürgen, Grewal, Jagvir, Groves, Christopher J., Haller, Toomas, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heikkilä, Kauko, Herzig, Karl-Heinz, Helmer, Quinta, Hillege, Hans L., Holmen, Oddgeir, Hunt, Steven C., Isaacs, Aaron, Ittermann, Till, James, Alan L., Johansson, Ingegerd, Juliusdottir, Thorhildur, Kalafati, Ioanna-Panagiota, Kinnunen, Leena, Koenig, Wolfgang, Kooner, Ishminder K., Kratzer, Wolfgang, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindström, Jaana, Lobbens, Stéphane, Lorentzon, Mattias, Mach, François, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Mills, Rebecca, Moayyeri, Alireza, Monda, Keri L., Mooijaart, Simon P., Mühleisen, Thomas W., Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Nagaraja, Ramaiah, Nalls, Michael A., Narisu, Narisu, Glorioso, Nicola, Nolte, Ilja M., Olden, Matthias, Rayner, Nigel W., Renstrom, Frida, Ried, Janina S., Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Sennblad, Bengt, Seufferlein, Thomas, Sitlani, Colleen M., Vernon Smith, Albert, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvänen, Ann-Christine, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tomaschitz, Andreas, Troffa, Chiara, van Oort, Floor V. A., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Wennauer, Roman, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Zhang, Qunyuan, Hua Zhao, Jing, Brennan, Eoin P., Choi, Murim, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Gharavi, Ali G., Hedman, Åsa K., Hivert, Marie-France, Huang, Jinyan, Kanoni, Stavroula, Karpe, Fredrik, Keildson, Sarah, Kiryluk, Krzysztof, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McKnight, Amy J., McPherson, Ruth, Metspalu, Andres, Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Olsson, Christian, Perry, John R. B., Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Schadt, Eric E., Scott, Robert A., Stolk, Lisette, Vallejo, Edgar E., Westra, Harm-Jan, Zondervan, Krina T., Amouyel, Philippe, Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Brown, Morris J., Burnier, Michel, Campbell, Harry, Chakravarti, Aravinda, Chines, Peter S., Claudi-Boehm, Simone, Collins, Francis S., Crawford, Dana C., Danesh, John, de Faire, Ulf, de Geus, Eco J. C., Dörr, Marcus, Erbel, Raimund, Eriksson, Johan G., Farrall, Martin, Ferrannini, Ele, Ferrières, Jean, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gieger, Christian, Gudnason, Vilmundur, Haiman, Christopher A., Harris, Tamara B., Hattersley, Andrew T., Heliövaara, Markku, Hicks, Andrew A., Hingorani, Aroon D., Hoffmann, Wolfgang, Hofman, Albert, Homuth, Georg, Humphries, Steve E., Hyppönen, Elina, Illig, Thomas, Jarvelin, Marjo-Riitta, Johansen, Berit, Jousilahti, Pekka, Jula, Antti M., Kaprio, Jaakko, Kee, Frank, Keinanen-Kiukaanniemi, Sirkka M., Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Musk, Arthur W., Möhlenkamp, Stefan, Morris, Andrew D., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Palmer, Lyle J., Penninx, Brenda W., Peters, Annette, Pramstaller, Peter P., Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schwarz, Peter E. H., Shuldiner, Alan R., Staessen, Jan A., Steinthorsdottir, Valgerdur, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Tremblay, Angelo, Tremoli, Elena, Vohl, Marie-Claude, Völker, Uwe, Vollenweider, Peter, Wilson, James F., Witteman, Jacqueline C., Adair, Linda S., Bochud, Murielle, Boehm, Bernhard O., Bornstein, Stefan R., Bouchard, Claude, Cauchi, Stéphane, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Cooper, Richard S., Dedoussis, George, Ferrucci, Luigi, Froguel, Philippe, Grabe, Hans-Jörgen, Hamsten, Anders, Hui, Jennie, Hveem, Kristian, Jöckel, Karl-Heinz, Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, März, Winfried, Munroe, Patricia B., Njølstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Pérusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sinisalo, Juha, Eline Slagboom, P., Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Veronesi, Giovanni, Walker, Mark, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H-Erich, Abecasis, Goncalo R., Assimes, Themistocles L., Berndt, Sonja I., Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Franke, Lude, Frayling, Timothy M., Groop, Leif C., Hunter, David J., Kaplan, Robert C., O’Connell, Jeffrey R., Qi, Lu, Schlessinger, David, Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Willer, Cristen J., Visscher, Peter M., Yang, Jian, Hirschhorn, Joel N., Carola Zillikens, M., McCarthy, Mark I., Speliotes, Elizabeth K., North, Kari E., Fox, Caroline S., Barroso, Inês, Franks, Paul W., Ingelsson, Erik, Heid, Iris M., Loos, Ruth J. F., Cupples, L. Adrienne, Morris, Andrew P., Lindgren, Cecilia M., Mohlke, Karen L, Devuyst, Olivier, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Shungin, Dmitry, Winkler, Thomas W., Croteau-Chonka, Damien C., Ferreira, Teresa, Locke, Adam E., Mägi, Reedik, Strawbridge, Rona J., Pers, Tune H., Fischer, Krista, Justice, Anne E., Workalemahu, Tsegaselassie, Wu, Joseph M. W., Buchkovich, Martin L., Heard-Costa, Nancy L., Roman, Tamara S., Drong, Alexander W., Song, Ci, Gustafsson, Stefan, Day, Felix R., Esko, Tonu, Fall, Tove, Kutalik, Zoltán, Luan, Jian’an, Randall, Joshua C., Scherag, André, Vedantam, Sailaja, Wood, Andrew R., Chen, Jin, Fehrmann, Rudolf, Karjalainen, Juha, Kahali, Bratati, Liu, Ching-Ti, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bragg-Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Ehret, Georg B., Feitosa, Mary F., Goel, Anuj, Jackson, Anne U., Johnson, Toby, Kleber, Marcus E., Kristiansson, Kati, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Stančáková, Alena, Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Van Vliet-Ostaptchouk, Jana V., Yengo, Loïc, Zhang, Weihua, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Bandinelli, Stefania, Barrett, Amy, Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blüher, Matthias, Böhringer, Stefan, Bonnet, Fabrice, Böttcher, Yvonne, Bruinenberg, Marcel, Carba, Delia B., Caspersen, Ida H., Clarke, Robert, Warwick Daw, E., Deelen, Joris, Deelman, Ewa, Delgado, Graciela, Doney, Alex S. F., Eklund, Niina, Erdos, Michael R., Estrada, Karol, Eury, Elodie, Friedrich, Nele, Garcia, Melissa E., Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Grallert, Harald, Grammer, Tanja B., Gräßler, Jürgen, Grewal, Jagvir, Groves, Christopher J., Haller, Toomas, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heikkilä, Kauko, Herzig, Karl-Heinz, Helmer, Quinta, Hillege, Hans L., Holmen, Oddgeir, Hunt, Steven C., Isaacs, Aaron, Ittermann, Till, James, Alan L., Johansson, Ingegerd, Juliusdottir, Thorhildur, Kalafati, Ioanna-Panagiota, Kinnunen, Leena, Koenig, Wolfgang, Kooner, Ishminder K., Kratzer, Wolfgang, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindström, Jaana, Lobbens, Stéphane, Lorentzon, Mattias, Mach, François, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Mills, Rebecca, Moayyeri, Alireza, Monda, Keri L., Mooijaart, Simon P., Mühleisen, Thomas W., Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Nagaraja, Ramaiah, Nalls, Michael A., Narisu, Narisu, Glorioso, Nicola, Nolte, Ilja M., Olden, Matthias, Rayner, Nigel W., Renstrom, Frida, Ried, Janina S., Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Sennblad, Bengt, Seufferlein, Thomas, Sitlani, Colleen M., Vernon Smith, Albert, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvänen, Ann-Christine, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tomaschitz, Andreas, Troffa, Chiara, van Oort, Floor V. A., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Wennauer, Roman, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Zhang, Qunyuan, Hua Zhao, Jing, Brennan, Eoin P., Choi, Murim, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Gharavi, Ali G., Hedman, Åsa K., Hivert, Marie-France, Huang, Jinyan, Kanoni, Stavroula, Karpe, Fredrik, Keildson, Sarah, Kiryluk, Krzysztof, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McKnight, Amy J., McPherson, Ruth, Metspalu, Andres, Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Olsson, Christian, Perry, John R. B., Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Schadt, Eric E., Scott, Robert A., Stolk, Lisette, Vallejo, Edgar E., Westra, Harm-Jan, Zondervan, Krina T., Amouyel, Philippe, Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Brown, Morris J., Burnier, Michel, Campbell, Harry, Chakravarti, Aravinda, Chines, Peter S., Claudi-Boehm, Simone, Collins, Francis S., Crawford, Dana C., Danesh, John, de Faire, Ulf, de Geus, Eco J. C., Dörr, Marcus, Erbel, Raimund, Eriksson, Johan G., Farrall, Martin, Ferrannini, Ele, Ferrières, Jean, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gieger, Christian, Gudnason, Vilmundur, Haiman, Christopher A., Harris, Tamara B., Hattersley, Andrew T., Heliövaara, Markku, Hicks, Andrew A., Hingorani, Aroon D., Hoffmann, Wolfgang, Hofman, Albert, Homuth, Georg, Humphries, Steve E., Hyppönen, Elina, Illig, Thomas, Jarvelin, Marjo-Riitta, Johansen, Berit, Jousilahti, Pekka, Jula, Antti M., Kaprio, Jaakko, Kee, Frank, Keinanen-Kiukaanniemi, Sirkka M., Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Musk, Arthur W., Möhlenkamp, Stefan, Morris, Andrew D., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Palmer, Lyle J., Penninx, Brenda W., Peters, Annette, Pramstaller, Peter P., Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schwarz, Peter E. H., Shuldiner, Alan R., Staessen, Jan A., Steinthorsdottir, Valgerdur, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Tremblay, Angelo, Tremoli, Elena, Vohl, Marie-Claude, Völker, Uwe, Vollenweider, Peter, Wilson, James F., Witteman, Jacqueline C., Adair, Linda S., Bochud, Murielle, Boehm, Bernhard O., Bornstein, Stefan R., Bouchard, Claude, Cauchi, Stéphane, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Cooper, Richard S., Dedoussis, George, Ferrucci, Luigi, Froguel, Philippe, Grabe, Hans-Jörgen, Hamsten, Anders, Hui, Jennie, Hveem, Kristian, Jöckel, Karl-Heinz, Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, März, Winfried, Munroe, Patricia B., Njølstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Pérusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sinisalo, Juha, Eline Slagboom, P., Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Veronesi, Giovanni, Walker, Mark, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H-Erich, Abecasis, Goncalo R., Assimes, Themistocles L., Berndt, Sonja I., Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Franke, Lude, Frayling, Timothy M., Groop, Leif C., Hunter, David J., Kaplan, Robert C., O’Connell, Jeffrey R., Qi, Lu, Schlessinger, David, Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Willer, Cristen J., Visscher, Peter M., Yang, Jian, Hirschhorn, Joel N., Carola Zillikens, M., McCarthy, Mark I., Speliotes, Elizabeth K., North, Kari E., Fox, Caroline S., Barroso, Inês, Franks, Paul W., Ingelsson, Erik, Heid, Iris M., Loos, Ruth J. F., Cupples, L. Adrienne, Morris, Andrew P., Lindgren, Cecilia M., Mohlke, Karen L, and Devuyst, Olivier
Published: 2015

30. The transcriptional landscape of age in human peripheral blood

Author: Peters, Marjolein J., Joehanes, Roby, Pilling, Luke C., Schurmann, Claudia, Conneely, Karen N., Powell, Joseph, Reinmaa, Eva, Sutphin, George L., Zhernakova, Alexandra, Schramm, Katharina, Wilson, Yana A., Kobes, Sayuko, Tukiainen, Taru, Ramos, Yolande F., Göring, Harald H.H., Fornage, Myriam, Liu, Yongmei, Gharib, Sina A., Stranger, Barbara E., De Jager, Philip L., Aviv, Abraham, Levy, Daniel, Murabito, Joanne M., Munson, Peter J., Huan, Tianxiao, Hofman, Albert, Uitterlinden, André G., Rivadeneira, Fernando, Van Rooij, Jeroen, Stolk, Lisette, Broer, Linda, Verbiest, Michael M.P.J., Jhamai, Mila, Arp, Pascal, Metspalu, Andres, Tserel, Liina, Milani, Lili, Samani, Nilesh J., Peterson, Pärt, Kasela, Silva, Codd, Veryan, Peters, Annette, Ward-Caviness, Cavin K., Herder, Christian, Waldenberger, Melanie, Roden, Michael, Singmann, Paula, Zeilinger, Sonja, Illig, Thomas, Homuth, Georg, Grabe, Hans Jörgen, Völzke, Henry, Steil, Leif, Kocher, Thomas, Murray, Anna, Melzer, David, Yaghootkar, Hanieh, Bandinelli, Stefania, Moses, Eric K., Kent, Jack W., Curran, Joanne E., Johnson, Matthew P., Williams-Blangero, Sarah, Westra, Harm Jan, McRae, Allan F., Smith, Jennifer A., Kardia, Sharon L.R., Hovatta, Iiris, Perola, Markus, Ripatti, Samuli, Salomaa, Veikko, Henders, Anjali K., Martin, Nicholas G., Smith, Alicia K., Mehta, Divya, Binder, Elisabeth B., Nylocks, K. Maria, Kennedy, Elizabeth M., Klengel, Torsten, Ding, Jingzhong, Suchy-Dicey, Astrid M., Enquobahrie, Daniel A., Brody, Jennifer, Rotter, Jerome I., Chen, Yii Der I., Houwing-Duistermaat, Jeanine, Kloppenburg, Margreet, Slagboom, P. Eline, Helmer, Quinta, Den Hollander, Wouter, Bean, Shannon, Raj, Towfique, Bakhshi, Noman, Wang, Qiao Ping, Oyston, Lisa J., Psaty, Bruce M., Tracy, Russell P., Montgomery, Grant W., Turner, Stephen T., Blangero, John, Meulenbelt, Ingrid, Ressler, Kerry J., Yang, Jian, Franke, Lude, Kettunen, Johannes, Visscher, Peter M., Neely, G. Gregory, Korstanje, Ron, Hanson, Robert L., Prokisch, Holger, Ferrucci, Luigi, Esko, Tonu, Teumer, Alexander, Van Meurs, Joyce B.J., Johnson, Andrew D., Nalls, Michael A., Hernandez, Dena G., Cookson, Mark R., Gibbs, Raphael J., Hardy, John, Ramasamy, Adaikalavan, Zonderman, Alan B., Dillman, Allissa, Traynor, Bryan, Smith, Colin, Longo, Dan L., Trabzuni, Daniah, Troncoso, Juan, Van Der Brug, Marcel, Weale, Michael E., O'Brien, Richard, Johnson, Robert, Walker, Robert, Zielke, Ronald H., Arepalli, Sampath, Ryten, Mina, Singleton, Andrew B., Peters, Marjolein J., Joehanes, Roby, Pilling, Luke C., Schurmann, Claudia, Conneely, Karen N., Powell, Joseph, Reinmaa, Eva, Sutphin, George L., Zhernakova, Alexandra, Schramm, Katharina, Wilson, Yana A., Kobes, Sayuko, Tukiainen, Taru, Ramos, Yolande F., Göring, Harald H.H., Fornage, Myriam, Liu, Yongmei, Gharib, Sina A., Stranger, Barbara E., De Jager, Philip L., Aviv, Abraham, Levy, Daniel, Murabito, Joanne M., Munson, Peter J., Huan, Tianxiao, Hofman, Albert, Uitterlinden, André G., Rivadeneira, Fernando, Van Rooij, Jeroen, Stolk, Lisette, Broer, Linda, Verbiest, Michael M.P.J., Jhamai, Mila, Arp, Pascal, Metspalu, Andres, Tserel, Liina, Milani, Lili, Samani, Nilesh J., Peterson, Pärt, Kasela, Silva, Codd, Veryan, Peters, Annette, Ward-Caviness, Cavin K., Herder, Christian, Waldenberger, Melanie, Roden, Michael, Singmann, Paula, Zeilinger, Sonja, Illig, Thomas, Homuth, Georg, Grabe, Hans Jörgen, Völzke, Henry, Steil, Leif, Kocher, Thomas, Murray, Anna, Melzer, David, Yaghootkar, Hanieh, Bandinelli, Stefania, Moses, Eric K., Kent, Jack W., Curran, Joanne E., Johnson, Matthew P., Williams-Blangero, Sarah, Westra, Harm Jan, McRae, Allan F., Smith, Jennifer A., Kardia, Sharon L.R., Hovatta, Iiris, Perola, Markus, Ripatti, Samuli, Salomaa, Veikko, Henders, Anjali K., Martin, Nicholas G., Smith, Alicia K., Mehta, Divya, Binder, Elisabeth B., Nylocks, K. Maria, Kennedy, Elizabeth M., Klengel, Torsten, Ding, Jingzhong, Suchy-Dicey, Astrid M., Enquobahrie, Daniel A., Brody, Jennifer, Rotter, Jerome I., Chen, Yii Der I., Houwing-Duistermaat, Jeanine, Kloppenburg, Margreet, Slagboom, P. Eline, Helmer, Quinta, Den Hollander, Wouter, Bean, Shannon, Raj, Towfique, Bakhshi, Noman, Wang, Qiao Ping, Oyston, Lisa J., Psaty, Bruce M., Tracy, Russell P., Montgomery, Grant W., Turner, Stephen T., Blangero, John, Meulenbelt, Ingrid, Ressler, Kerry J., Yang, Jian, Franke, Lude, Kettunen, Johannes, Visscher, Peter M., Neely, G. Gregory, Korstanje, Ron, Hanson, Robert L., Prokisch, Holger, Ferrucci, Luigi, Esko, Tonu, Teumer, Alexander, Van Meurs, Joyce B.J., Johnson, Andrew D., Nalls, Michael A., Hernandez, Dena G., Cookson, Mark R., Gibbs, Raphael J., Hardy, John, Ramasamy, Adaikalavan, Zonderman, Alan B., Dillman, Allissa, Traynor, Bryan, Smith, Colin, Longo, Dan L., Trabzuni, Daniah, Troncoso, Juan, Van Der Brug, Marcel, Weale, Michael E., O'Brien, Richard, Johnson, Robert, Walker, Robert, Zielke, Ronald H., Arepalli, Sampath, Ryten, Mina, and Singleton, Andrew B.
Abstract: Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the 'transcriptomic age' of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts.
Published: 2015

31. Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Author: JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Cardiovasculaire Epidemiologie, Wessel, Jennifer, Chu, Audrey Y., Willems, Sara M., Wang, Shuai, Yaghootkar, Hanieh, Brody, Jennifer A., Dauriz, Marco, Hivert, Marie-France, Raghavan, Sridharan, Lipovich, Leonard, Hidalgo, Bertha, Fox, Keolu, Huffman, Jennifer E., An, Ping, Lu, Yingchang, Rasmussen-Torvik, Laura J., Grarup, Niels, Ehm, Margaret G., Li, Li, Baldridge, Abigail S., Stancakova, Alena, Abrol, Ravinder, Besse, Celine, Boland, Anne, Bork-Jensen, Jette, Fornage, Myriam, Freitag, Daniel F., Garcia, Melissa E., Guo, Xiuqing, Hara, Kazuo, Isaacs, Aaron, Jakobsdottir, Johanna, Lange, Leslie A., Layton, Jill C., Li, Man, Zhao, Jing Hua, Meidtner, Karina, Morrison, Alanna C., Nalls, Mike A., Peters, Marjolein J., Sabater-Lleal, Maria, Schurmann, Claudia, Silveira, Angela, Smith, Albert V., Southam, Lorraine, Stoiber, Marcus H., Strawbridge, Rona J., Taylor, Kent D., Varga, Tibor V., van der Schouw, Yvonne T., The EPIC-InterAct Consortium, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Cardiovasculaire Epidemiologie, Wessel, Jennifer, Chu, Audrey Y., Willems, Sara M., Wang, Shuai, Yaghootkar, Hanieh, Brody, Jennifer A., Dauriz, Marco, Hivert, Marie-France, Raghavan, Sridharan, Lipovich, Leonard, Hidalgo, Bertha, Fox, Keolu, Huffman, Jennifer E., An, Ping, Lu, Yingchang, Rasmussen-Torvik, Laura J., Grarup, Niels, Ehm, Margaret G., Li, Li, Baldridge, Abigail S., Stancakova, Alena, Abrol, Ravinder, Besse, Celine, Boland, Anne, Bork-Jensen, Jette, Fornage, Myriam, Freitag, Daniel F., Garcia, Melissa E., Guo, Xiuqing, Hara, Kazuo, Isaacs, Aaron, Jakobsdottir, Johanna, Lange, Leslie A., Layton, Jill C., Li, Man, Zhao, Jing Hua, Meidtner, Karina, Morrison, Alanna C., Nalls, Mike A., Peters, Marjolein J., Sabater-Lleal, Maria, Schurmann, Claudia, Silveira, Angela, Smith, Albert V., Southam, Lorraine, Stoiber, Marcus H., Strawbridge, Rona J., Taylor, Kent D., Varga, Tibor V., van der Schouw, Yvonne T., and The EPIC-InterAct Consortium
Published: 2015

32. Determinants for Quantitative Sensory Testing and the Association with Chronic Musculoskeletal Pain in the General Elderly Population

Author: de Kruijf, Marjolein, primary, Peters, Marjolein J., additional, C. Jacobs, Leonie, additional, Tiemeier, Henning, additional, Nijsten, Tamar, additional, Hofman, Albert, additional, Uitterlinden, Andre G., additional, Huygen, Frank J. P. M., additional, and van Meurs, Joyce B. J., additional
Published: 2015
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33. Tobacco smoking is associated with methylation of genes related to coronary artery disease

Author: Steenaard, Rebecca V, primary, Ligthart, Symen, additional, Stolk, Lisette, additional, Peters, Marjolein J, additional, van Meurs, Joyce B, additional, Uitterlinden, Andre G, additional, Hofman, Albert, additional, Franco, Oscar H, additional, and Dehghan, Abbas, additional
Published: 2015
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34. Cell Specific eQTL Analysis without Sorting Cells

Author: Westra, Harm-Jan, primary, Arends, Danny, additional, Esko, Tõnu, additional, Peters, Marjolein J., additional, Schurmann, Claudia, additional, Schramm, Katharina, additional, Kettunen, Johannes, additional, Yaghootkar, Hanieh, additional, Fairfax, Benjamin P., additional, Andiappan, Anand Kumar, additional, Li, Yang, additional, Fu, Jingyuan, additional, Karjalainen, Juha, additional, Platteel, Mathieu, additional, Visschedijk, Marijn, additional, Weersma, Rinse K., additional, Kasela, Silva, additional, Milani, Lili, additional, Tserel, Liina, additional, Peterson, Pärt, additional, Reinmaa, Eva, additional, Hofman, Albert, additional, Uitterlinden, André G., additional, Rivadeneira, Fernando, additional, Homuth, Georg, additional, Petersmann, Astrid, additional, Lorbeer, Roberto, additional, Prokisch, Holger, additional, Meitinger, Thomas, additional, Herder, Christian, additional, Roden, Michael, additional, Grallert, Harald, additional, Ripatti, Samuli, additional, Perola, Markus, additional, Wood, Andrew R., additional, Melzer, David, additional, Ferrucci, Luigi, additional, Singleton, Andrew B., additional, Hernandez, Dena G., additional, Knight, Julian C., additional, Melchiotti, Rossella, additional, Lee, Bernett, additional, Poidinger, Michael, additional, Zolezzi, Francesca, additional, Larbi, Anis, additional, Wang, De Yun, additional, van den Berg, Leonard H., additional, Veldink, Jan H., additional, Rotzschke, Olaf, additional, Makino, Seiko, additional, Salomaa, Veikko, additional, Strauch, Konstantin, additional, Völker, Uwe, additional, van Meurs, Joyce B. J., additional, Metspalu, Andres, additional, Wijmenga, Cisca, additional, Jansen, Ritsert C., additional, and Franke, Lude, additional
Published: 2015
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35. Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity.

Author: Sutphin, George L., Backer, Grant, Sheehan, Susan, Bean, Shannon, Corban, Caroline, Liu, Teresa, Peters, Marjolein J., Meurs, Joyce B. J., Murabito, Joanne M., Johnson, Andrew D., and Korstanje, Ron
Subjects: CAENORHABDITIS elegans genetics, GENE expression, GENETICS of longevity, KYNURENINASE, CALCIUM channels, HUMAN genetics
Abstract: We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age. We find substantial enrichment in genes for which knockdown increased lifespan. This enrichment is markedly higher than published genomewide longevity screens in C. elegans and similar to screens that preselected candidates based on longevity-correlated metrics (e.g., stress resistance). Of the 50 genes that affected lifespan, 46 were previously unreported. The five genes with the greatest impact on lifespan (>20% extension) encode the enzyme kynureninase ( kynu-1), a neuronal leucine-rich repeat protein ( iglr-1), a tetraspanin ( tsp-3), a regulator of calcineurin ( rcan-1), and a voltage-gated calcium channel subunit ( unc-36). Knockdown of each gene extended healthspan without impairing reproduction. kynu-1( RNAi) alone delayed pathology in C. elegans models of Alzheimer's disease and Huntington's disease. Each gene displayed a distinct pattern of interaction with known aging pathways. In the context of published work, kynu-1, tsp-3, and rcan-1 are of particular interest for immediate follow-up. kynu-1 is an understudied member of the kynurenine metabolic pathway with a mechanistically distinct impact on lifespan. Our data suggest that tsp-3 is a novel modulator of hypoxic signaling and rcan-1 is a context-specific calcineurin regulator. Our results validate C. elegans as a comparative tool for prioritizing human candidate aging genes, confirm age-associated gene expression data as valuable source of novel longevity determinants, and prioritize select genes for mechanistic follow-up. [ABSTRACT FROM AUTHOR]
Published: 2017
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36. Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations.

Author: Chen, Brian H, Hivert, Marie-France, Peters, Marjolein J, Pilling, Luke C, Hogan, John D, Pham, Lisa M, Harries, Lorna W, Fox, Caroline S, Bandinelli, Stefania, Dehghan, Abbas, Hernandez, Dena G, Hofman, Albert, Hong, Jaeyoung, Joehanes, Roby, Johnson, Andrew D, Munson, Peter J, Rybin, Denis V, Singleton, Andrew B, Uitterlinden, André G, and Ying, Saixia
Subjects: BLOOD sugar, DISEASE susceptibility, FASTING, GENES, INSULIN, PROTEINS, RESEARCH funding, RNA, GENE expression profiling, SEQUENCE analysis, GENOTYPES
Abstract: Genome-wide association studies (GWAS) have successfully identified genetic loci associated with glycemic traits. However, characterizing the functional significance of these loci has proven challenging. We sought to gain insights into the regulation of fasting insulin and fasting glucose through the use of gene expression microarray data from peripheral blood samples of participants without diabetes in the Framingham Heart Study (FHS) (n = 5,056), the Rotterdam Study (RS) (n = 723), and the InCHIANTI Study (Invecchiare in Chianti) (n = 595). Using a false discovery rate q <0.05, we identified three transcripts associated with fasting glucose and 433 transcripts associated with fasting insulin levels after adjusting for age, sex, technical covariates, and complete blood cell counts. Among the findings, circulating IGF2BP2 transcript levels were positively associated with fasting insulin in both the FHS and RS. Using 1000 Genomes-imputed genotype data, we identified 47,587 cis-expression quantitative trait loci (eQTL) and 6,695 trans-eQTL associated with the 433 significant insulin-associated transcripts. Of note, we identified a trans-eQTL (rs592423), where the A allele was associated with higher IGF2BP2 levels and with fasting insulin in an independent genetic meta-analysis comprised of 50,823 individuals. We conclude that integration of genomic and transcriptomic data implicate circulating IGF2BP2 mRNA levels associated with glucose and insulin homeostasis. [ABSTRACT FROM AUTHOR]
Published: 2016

37. A whole-blood transcriptome meta-analysis identifies gene expression signatures of cigarette smoking.

Author: Tianxiao Huan, Joehanes, Roby, Schurmann, Claudia, Schramm, Katharina, Pilling, Luke C., Peters, Marjolein J., Mägi, Reedik, DeMeo, Dawn, O’Connor, George T., Ferrucci, Luigi, Teumer, Alexander, Homuth, Georg, Biffar, Reiner, Völker, Uwe, Herder, Christian, Waldenberger, Melanie, Peters, Annette, Zeilinger, Sonja, Metspalu, Andres, and Hofman, Albert
Published: 2016
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38. Finger Length Pattern as a Biomarker for Osteoarthritis and Chronic Joint Pain: A Population‐Based Study and Meta‐Analysis After Systematic Review

Author: de Kruijf, Marjolein, primary, Kerkhof, Hanneke J. M., additional, Peters, Marjolein J., additional, Bierma‐Zeinstra, Sita, additional, Hofman, Albert, additional, Uitterlinden, Andre G., additional, Huggen, Frank J. P. M., additional, and van Meurs, Joyce B. J., additional
Published: 2014
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39. Abstract 35: Transcriptome-wide Association Study of Circulating Lipid Levels

Author: Chen, Brian H, primary, Schurmann, Claudia, additional, Peters, Marjolein J, additional, Pfeiffer, Liliane, additional, Schramm, Katharina, additional, Pilling, Luke C, additional, Joehanes, Roby, additional, Freeman, Lita, additional, Yaghootkar, Hanieh, additional, Esko, Tonu, additional, Cupples, L. Adrienne, additional, Grallert, Harald, additional, Johnson, Andrew D, additional, Kathiresan, Sekar, additional, Munson, Peter J, additional, Reischl, Eva, additional, Waldenberger, Melanie, additional, Ying, Saixia, additional, Melzer, David, additional, Ferrucci, Luigi, additional, Prokisch, Holger, additional, Herder, Christian, additional, Isaacs, Aaron, additional, Levy, Daniel, additional, and Teumer, Alexander, additional
Published: 2014
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40. Cell specific eQTL analysis without sorting cells

Author: Westra, Harm-Jan, primary, Arends, Danny, additional, Esko, Tõnu, additional, Peters, Marjolein J., additional, Schurmann, Claudia, additional, Schramm, Katharina, additional, Kettunen, Johannes, additional, Yaghootkar, Hanieh, additional, Fairfax, Benjamin, additional, Andiappan, Anand Kumar, additional, Li, Yang, additional, Fu, Jingyuan, additional, Karjalainen, Juha, additional, Platteel, Mathieu, additional, Visschedijk, Marijn, additional, Weersma, Rinse, additional, Kasela, Silva, additional, Milani, Lili, additional, Tserel, Liina, additional, Peterson, Pärt, additional, Reinmaa, Eva, additional, Hofman, Albert, additional, Uitterlinden, André G., additional, Rivadeneira, Fernando, additional, Homuth, Georg, additional, Petersmann, Astrid, additional, Lorbeer, Roberto, additional, Prokisch, Holger, additional, Meitinger, Thomas, additional, Herder, Christian, additional, Roden, Michael, additional, Grallert, Harald, additional, Ripatti, Samuli, additional, Perola, Markus, additional, Wood, Adrew R., additional, Melzer, David, additional, Ferrucci, Luigi, additional, Singleton, Andrew B., additional, Hernandez, Dena G., additional, Knight, Julian C., additional, Melchiotti, Rossella, additional, Lee, Bernett, additional, Poidinger, Michael, additional, Zolezzi, Francesca, additional, Larbi, Anis, additional, Wang, De Yun, additional, van den Berg, Leonard H., additional, Veldink, Jan H., additional, Rotzschke, Olaf, additional, Makino, Seiko, additional, Frayling, Timouthy, additional, Salomaa, Veikko, additional, Strauch, Konstantin, additional, Völker, Uwe, additional, van Meurs, Joyce B.J., additional, Metspalu, Andres, additional, Wijmenga, Cisca, additional, Jansen, Ritsert C., additional, and Franke, Lude, additional
Published: 2014
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41. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Author: Berndt, Sonja I., Gustafsson, Stefan, Maegi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F., Justice, Anne E., Monda, Keri L., Croteau-Chonka, Damien C., Day, Felix R., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U., Luan, Jian'an, Randall, Joshua C., Vedantam, Sailaja, Willer, Cristen J., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Hu, Yi-Juan, Lee, Sang Hong, Liang, Liming, Lin, Dan-Yu, Min, Josine L., Neale, Benjamin M., Thorleifsson, Gudmar, Yang, Jian, Albrecht, Eva, Amin, Najaf, Bragg-Gresham, Jennifer L., Cadby, Gemma, den Heijer, Martin, Eklund, Niina, Fischer, Krista, Goel, Anuj, Hottenga, Jouke-Jan, Huffman, Jennifer E., Jarick, Ivonne, Johansson, Åsa, Johnson, Toby, Kanoni, Stavroula, Kleber, Marcus E., Koenig, Inke R., Kristiansson, Kati, Kutalik, Zoltn, Lamina, Claudia, Lecoeur, Cecile, Li, Guo, Mangino, Massimo, McArdle, Wendy L., Medina-Gomez, Carolina, Mueller-Nurasyid, Martina, Ngwa, Julius S., Nolte, Ilja M., Paternoster, Lavinia, Pechlivanis, Sonali, Perola, Markus, Peters, Marjolein J., Preuss, Michael, Rose, Lynda M., Shi, Jianxin, Shungin, Dmitry, Smith, Albert Vernon, Strawbridge, Rona J., Surakka, Ida, Teumer, Alexander, Trip, Mieke D., Tyrer, Jonathan, Van Vliet-Ostaptchouk, Jana V., Vandenput, Liesbeth, Waite, Lindsay L., Zhao, Jing Hua, Absher, Devin, Asselbergs, Folkert W., Atalay, Mustafa, Attwood, Antony P., Balmforth, Anthony J., Basart, Hanneke, Beilby, John, Bonnycastle, Lori L., Brambilla, Paolo, Bruinenberg, Marcel, Campbell, Harry, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Connell, John M., Cookson, William O., de Faire, Ulf, de Vegt, Femmie, Dei, Mariano, Dimitriou, Maria, Edkins, Sarah, Estrada, Karol, Evans, David M., Farrall, Martin, Ferrario, Marco M., Ferrieres, Jean, Franke, Lude, Frau, Francesca, Gejman, Pablo V., Grallert, Harald, Groenberg, Henrik, Gudnason, Vilmundur, Hall, Alistair S., Hall, Per, Hartikainen, Anna-Liisa, Hayward, Caroline, Heard-Costa, Nancy L., Heath, Andrew C., Hebebrand, Johannes, Homuth, Georg, Hu, Frank B., Hunt, Sarah E., Hyppoenen, Elina, Iribarren, Carlos, Jacobs, Kevin B., Jansson, John-Olov, Jula, Antti, Kahonen, Mika, Kathiresan, Sekar, Kee, Frank, Khaw, Kay-Tee, Kivimaki, Mika, Koenig, Wolfgang, Kraja, Aldi T., Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Laitinen, Jaana H., Lakka, Timo A., Langenberg, Claudia, Launer, Lenore J., Lind, Lars, Lindström, Jaana, Liu, Jianjun, Liuzzi, Antonio, Lokki, Marja-Liisa, Lorentzon, Mattias, Madden, Pamela A., Magnusson, Patrik K., Manunta, Paolo, Marek, Diana, März, Winfried, Leach, Irene Mateo, McKnight, Barbara, Medland, Sarah E., Mihailov, Evelin, Milani, Lili, Montgomery, Grant W., Mooser, Vincent, Muehleisen, Thomas W., Munroe, Patricia B., Musk, Arthur W., Narisu, Narisu, Navis, Gerjan, Nicholson, George, Nohr, Ellen A., Ong, Ken K., Oostra, Ben A., Palmer, Colin N. A., Palotie, Aarno, Peden, John F., Pedersen, Nancy, Peters, Annette, Polasek, Ozren, Pouta, Anneli, Pramstaller, Peter P., Prokopenko, Inga, Puetter, Carolin, Radhakrishnan, Aparna, Raitakari, Olli, Rendon, Augusto, Rivadeneira, Fernando, Rudan, Igor, Saaristo, Timo E., Sambrook, Jennifer G., Sanders, Alan R., Sanna, Serena, Saramies, Jouko, Schipf, Sabine, Schreiber, Stefan, Schunkert, Heribert, Shin, So-Youn, Signorini, Stefano, Sinisalo, Juha, Skrobek, Boris, Soranzo, Nicole, Stancakova, Alena, Stark, Klaus, Stephens, Jonathan C., Stirrups, Kathleen, Stolk, Ronald P., Stumvoll, Michael, Swift, Amy J., Theodoraki, Eirini V., Thorand, Barbara, Tregouet, David-Alexandre, Tremoli, Elena, Van der Klauw, Melanie M., van Meurs, Joyce B. J., Vermeulen, Sita H., Viikari, Jorma, Virtamo, Jarmo, Vitart, Veronique, Waeber, Gerard, Wang, Zhaoming, Widen, Elisabeth, Wild, Sarah H., Willemsen, Gonneke, Winkelmann, Bernhard R., Witteman, Jacqueline C. M., Wolffenbuttel, Bruce H. R., Wong, Andrew, Wright, Alan F., Zillikens, M. Carola, Amouyel, Philippe, Boehm, Bernhard O., Boerwinkle, Eric, Boomsma, Dorret I., Caulfield, Mark J., Chanock, Stephen J., Cupples, L. Adrienne, Cusi, Daniele, Dedoussis, George V., Erdmann, Jeanette, Eriksson, Johan G., Franks, Paul W., Froguel, Philippe, Gieger, Christian, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B., Hengstenberg, Christian, Hicks, Andrew A., Hingorani, Aroon, Hinney, Anke, Hofman, Albert, Hovingh, Kees G., Hveem, Kristian, Illig, Thomas, Jarvelin, Marjo-Riitta, Joeckel, Karl-Heinz, Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Kuh, Diana, Laakso, Markku, Lehtimaki, Terho, Levinson, Douglas F., Martin, Nicholas G., Metspalu, Andres, Morris, Andrew D., Nieminen, Markku S., Njolstad, Inger, Ohlsson, Claes, Oldehinkel, Albertine J., Ouwehand, Willem H., Palmer, Lyle J., Penninx, Brenda, Power, Chris, Province, Michael A., Psaty, Bruce M., Qi, Lu, Rauramaa, Rainer, Ridker, Paul M., Ripatti, Samuli, Salomaa, Veikko, Samani, Nilesh J., Snieder, Harold, Sorensen, Thorkild I. A., Spector, Timothy D., Stefansson, Kari, Tonjes, Anke, Tuomilehto, Jaakko, Uitterlinden, Andre G., Uusitupa, Matti, van der Harst, Pim, Vollenweider, Peter, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H-Erich, Wilson, James F., Abecasis, Goncalo R., Assimes, Themistocles L., Barroso, Ines, Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Frayling, Timothy, Groop, Leif C., Haritunian, Talin, Heid, Iris M., Hunter, David, Kaplan, Robert C., Karpe, Fredrik, Moffatt, Miriam F., Mohlke, Karen L., O'Connell, Jeffrey R., Pawitan, Yudi, Schadt, Eric E., Schlessinger, David, Steinthorsdottir, Valgerdur, Strachan, David P., Thorsteinsdottir, Unnur, van Duijn, Cornelia M., Visscher, Peter M., Di Blasio, Anna Maria, Hirschhorn, Joel N., Lindgren, Cecilia M., Morris, Andrew P., Meyre, David, Scherag, Andr, McCarthy, Mark I., Speliotes, Elizabeth K., North, Kari E., Loos, Ruth J. F., Ingelsson, Erik, Berndt, Sonja I., Gustafsson, Stefan, Maegi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F., Justice, Anne E., Monda, Keri L., Croteau-Chonka, Damien C., Day, Felix R., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U., Luan, Jian'an, Randall, Joshua C., Vedantam, Sailaja, Willer, Cristen J., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Hu, Yi-Juan, Lee, Sang Hong, Liang, Liming, Lin, Dan-Yu, Min, Josine L., Neale, Benjamin M., Thorleifsson, Gudmar, Yang, Jian, Albrecht, Eva, Amin, Najaf, Bragg-Gresham, Jennifer L., Cadby, Gemma, den Heijer, Martin, Eklund, Niina, Fischer, Krista, Goel, Anuj, Hottenga, Jouke-Jan, Huffman, Jennifer E., Jarick, Ivonne, Johansson, Åsa, Johnson, Toby, Kanoni, Stavroula, Kleber, Marcus E., Koenig, Inke R., Kristiansson, Kati, Kutalik, Zoltn, Lamina, Claudia, Lecoeur, Cecile, Li, Guo, Mangino, Massimo, McArdle, Wendy L., Medina-Gomez, Carolina, Mueller-Nurasyid, Martina, Ngwa, Julius S., Nolte, Ilja M., Paternoster, Lavinia, Pechlivanis, Sonali, Perola, Markus, Peters, Marjolein J., Preuss, Michael, Rose, Lynda M., Shi, Jianxin, Shungin, Dmitry, Smith, Albert Vernon, Strawbridge, Rona J., Surakka, Ida, Teumer, Alexander, Trip, Mieke D., Tyrer, Jonathan, Van Vliet-Ostaptchouk, Jana V., Vandenput, Liesbeth, Waite, Lindsay L., Zhao, Jing Hua, Absher, Devin, Asselbergs, Folkert W., Atalay, Mustafa, Attwood, Antony P., Balmforth, Anthony J., Basart, Hanneke, Beilby, John, Bonnycastle, Lori L., Brambilla, Paolo, Bruinenberg, Marcel, Campbell, Harry, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Connell, John M., Cookson, William O., de Faire, Ulf, de Vegt, Femmie, Dei, Mariano, Dimitriou, Maria, Edkins, Sarah, Estrada, Karol, Evans, David M., Farrall, Martin, Ferrario, Marco M., Ferrieres, Jean, Franke, Lude, Frau, Francesca, Gejman, Pablo V., Grallert, Harald, Groenberg, Henrik, Gudnason, Vilmundur, Hall, Alistair S., Hall, Per, Hartikainen, Anna-Liisa, Hayward, Caroline, Heard-Costa, Nancy L., Heath, Andrew C., Hebebrand, Johannes, Homuth, Georg, Hu, Frank B., Hunt, Sarah E., Hyppoenen, Elina, Iribarren, Carlos, Jacobs, Kevin B., Jansson, John-Olov, Jula, Antti, Kahonen, Mika, Kathiresan, Sekar, Kee, Frank, Khaw, Kay-Tee, Kivimaki, Mika, Koenig, Wolfgang, Kraja, Aldi T., Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Laitinen, Jaana H., Lakka, Timo A., Langenberg, Claudia, Launer, Lenore J., Lind, Lars, Lindström, Jaana, Liu, Jianjun, Liuzzi, Antonio, Lokki, Marja-Liisa, Lorentzon, Mattias, Madden, Pamela A., Magnusson, Patrik K., Manunta, Paolo, Marek, Diana, März, Winfried, Leach, Irene Mateo, McKnight, Barbara, Medland, Sarah E., Mihailov, Evelin, Milani, Lili, Montgomery, Grant W., Mooser, Vincent, Muehleisen, Thomas W., Munroe, Patricia B., Musk, Arthur W., Narisu, Narisu, Navis, Gerjan, Nicholson, George, Nohr, Ellen A., Ong, Ken K., Oostra, Ben A., Palmer, Colin N. A., Palotie, Aarno, Peden, John F., Pedersen, Nancy, Peters, Annette, Polasek, Ozren, Pouta, Anneli, Pramstaller, Peter P., Prokopenko, Inga, Puetter, Carolin, Radhakrishnan, Aparna, Raitakari, Olli, Rendon, Augusto, Rivadeneira, Fernando, Rudan, Igor, Saaristo, Timo E., Sambrook, Jennifer G., Sanders, Alan R., Sanna, Serena, Saramies, Jouko, Schipf, Sabine, Schreiber, Stefan, Schunkert, Heribert, Shin, So-Youn, Signorini, Stefano, Sinisalo, Juha, Skrobek, Boris, Soranzo, Nicole, Stancakova, Alena, Stark, Klaus, Stephens, Jonathan C., Stirrups, Kathleen, Stolk, Ronald P., Stumvoll, Michael, Swift, Amy J., Theodoraki, Eirini V., Thorand, Barbara, Tregouet, David-Alexandre, Tremoli, Elena, Van der Klauw, Melanie M., van Meurs, Joyce B. J., Vermeulen, Sita H., Viikari, Jorma, Virtamo, Jarmo, Vitart, Veronique, Waeber, Gerard, Wang, Zhaoming, Widen, Elisabeth, Wild, Sarah H., Willemsen, Gonneke, Winkelmann, Bernhard R., Witteman, Jacqueline C. M., Wolffenbuttel, Bruce H. R., Wong, Andrew, Wright, Alan F., Zillikens, M. Carola, Amouyel, Philippe, Boehm, Bernhard O., Boerwinkle, Eric, Boomsma, Dorret I., Caulfield, Mark J., Chanock, Stephen J., Cupples, L. Adrienne, Cusi, Daniele, Dedoussis, George V., Erdmann, Jeanette, Eriksson, Johan G., Franks, Paul W., Froguel, Philippe, Gieger, Christian, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B., Hengstenberg, Christian, Hicks, Andrew A., Hingorani, Aroon, Hinney, Anke, Hofman, Albert, Hovingh, Kees G., Hveem, Kristian, Illig, Thomas, Jarvelin, Marjo-Riitta, Joeckel, Karl-Heinz, Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Kuh, Diana, Laakso, Markku, Lehtimaki, Terho, Levinson, Douglas F., Martin, Nicholas G., Metspalu, Andres, Morris, Andrew D., Nieminen, Markku S., Njolstad, Inger, Ohlsson, Claes, Oldehinkel, Albertine J., Ouwehand, Willem H., Palmer, Lyle J., Penninx, Brenda, Power, Chris, Province, Michael A., Psaty, Bruce M., Qi, Lu, Rauramaa, Rainer, Ridker, Paul M., Ripatti, Samuli, Salomaa, Veikko, Samani, Nilesh J., Snieder, Harold, Sorensen, Thorkild I. A., Spector, Timothy D., Stefansson, Kari, Tonjes, Anke, Tuomilehto, Jaakko, Uitterlinden, Andre G., Uusitupa, Matti, van der Harst, Pim, Vollenweider, Peter, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H-Erich, Wilson, James F., Abecasis, Goncalo R., Assimes, Themistocles L., Barroso, Ines, Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Frayling, Timothy, Groop, Leif C., Haritunian, Talin, Heid, Iris M., Hunter, David, Kaplan, Robert C., Karpe, Fredrik, Moffatt, Miriam F., Mohlke, Karen L., O'Connell, Jeffrey R., Pawitan, Yudi, Schadt, Eric E., Schlessinger, David, Steinthorsdottir, Valgerdur, Strachan, David P., Thorsteinsdottir, Unnur, van Duijn, Cornelia M., Visscher, Peter M., Di Blasio, Anna Maria, Hirschhorn, Joel N., Lindgren, Cecilia M., Morris, Andrew P., Meyre, David, Scherag, Andr, McCarthy, Mark I., Speliotes, Elizabeth K., North, Kari E., Loos, Ruth J. F., and Ingelsson, Erik
Abstract: Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
Published: 2013
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42. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Author: Berndt, Sonja I, Gustafsson, Stefan, Mägi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F, Justice, Anne E, Monda, Keri L, Croteau-Chonka, Damien C, Day, Felix R, Esko, Tõnu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U, Luan, Jian'an, Randall, Joshua C, Vedantam, Sailaja, Willer, Cristen J, Winkler, Thomas, Wood, Andrew R, Workalemahu, Tsegaselassie, Hu, Yi-Juan, Lee, Sang Hong, Liang, Liming, Lin, Dan-Yu, Min, Josine L, Neale, Benjamin M, Thorleifsson, Gudmar, Yang, Jian, Albrecht, Eva, Amin, Najaf, Bragg-Gresham, Jennifer L, Cadby, Gemma, den Heijer, Martin, Eklund, Niina, Fischer, Krista, Goel, Anuj, Hottenga, Jouke-Jan, Huffman, Jennifer E, Jarick, Ivonne, Johansson, Åsa, Johnson, Toby, Kanoni, Stavroula, Kleber, Marcus E, König, Inke R, Kristiansson, Kati, Kutalik, Zoltán, Lamina, Claudia, Lecoeur, Cecile, Li, Guo, Mangino, Massimo, McArdle, Wendy L, Medina-Gomez, Carolina, Müller-Nurasyid, Martina, Ngwa, Julius S, Nolte, Ilja M, Paternoster, Lavinia, Pechlivanis, Sonali, Perola, Markus, Peters, Marjolein J, Preuss, Michael, Rose, Lynda M, Shi, Jianxin, Shungin, Dmitry, Smith, Albert Vernon, Strawbridge, Rona J, Surakka, Ida, Teumer, Alexander, Trip, Mieke D, Tyrer, Jonathan, Van Vliet-Ostaptchouk, Jana V, Vandenput, Liesbeth, Waite, Lindsay L, Zhao, Jing Hua, Absher, Devin, Asselbergs, Folkert W, Atalay, Mustafa, Attwood, Antony P, Balmforth, Anthony J, Basart, Hanneke, Beilby, John, Bonnycastle, Lori L, Brambilla, Paolo, Bruinenberg, Marcel, Campbell, Harry, Chasman, Daniel I, Chines, Peter S, Collins, Francis S, Connell, John M, Cookson, William O, de Faire, Ulf, de Vegt, Femmie, Dei, Mariano, Dimitriou, Maria, Edkins, Sarah, Estrada, Karol, Evans, David M, Farrall, Martin, Ferrario, Marco M, Ferrières, Jean, Franke, Lude, Frau, Francesca, Gejman, Pablo V, Grallert, Harald, Grönberg, Henrik, Gudnason, Vilmundur, Hall, Alistair S, Hall, Per, Hartikainen, Anna-Liisa, Hayward, Caroline, Heard-Costa, Nancy L, Heath, Andrew C, Hebebrand, Johannes, Homuth, Georg, Hu, Frank B, Hunt, Sarah E, Hyppönen, Elina, Iribarren, Carlos, Jacobs, Kevin B, Jansson, John-Olov, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Kee, Frank, Khaw, Kay-Tee, Kivimäki, Mika, Koenig, Wolfgang, Kraja, Aldi T, Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Laitinen, Jaana H, Lakka, Timo A, Langenberg, Claudia, Launer, Lenore J, Lind, Lars, Lindström, Jaana, Liu, Jianjun, Liuzzi, Antonio, Lokki, Marja-Liisa, Lorentzon, Mattias, Madden, Pamela A, Magnusson, Patrik K, Manunta, Paolo, Marek, Diana, März, Winfried, Mateo Leach, Irene, McKnight, Barbara, Medland, Sarah E, Mihailov, Evelin, Milani, Lili, Montgomery, Grant W, Mooser, Vincent, Mühleisen, Thomas W, Munroe, Patricia B, Musk, Arthur W, Narisu, Narisu, Navis, Gerjan, Nicholson, George, Nohr, Ellen A, Ong, Ken K, Oostra, Ben A, Palmer, Colin N A, Palotie, Aarno, Peden, John F, Pedersen, Nancy, Peters, Annette, Polasek, Ozren, Pouta, Anneli, Pramstaller, Peter P, Prokopenko, Inga, Pütter, Carolin, Radhakrishnan, Aparna, Raitakari, Olli, Rendon, Augusto, Rivadeneira, Fernando, Rudan, Igor, Saaristo, Timo E, Sambrook, Jennifer G, Sanders, Alan R, Sanna, Serena, Saramies, Jouko, Schipf, Sabine, Schreiber, Stefan, Schunkert, Heribert, Shin, So-Youn, Signorini, Stefano, Sinisalo, Juha, Skrobek, Boris, Soranzo, Nicole, Stan?áková, Alena, Stark, Klaus, Stephens, Jonathan C, Stirrups, Kathleen, Stolk, Ronald P, Stumvoll, Michael, Swift, Amy J, Theodoraki, Eirini V, Thorand, Barbara, Tregouet, David-Alexandre, Tremoli, Elena, Van der Klauw, Melanie M, van Meurs, Joyce B J, Vermeulen, Sita H, Viikari, Jorma, Virtamo, Jarmo, Vitart, Veronique, Waeber, Gérard, Wang, Zhaoming, Widén, Elisabeth, Wild, Sarah H, Willemsen, Gonneke, Winkelmann, Bernhard R, Witteman, Jacqueline C M, Wolffenbuttel, Bruce H R, Wong, Andrew, Wright, Alan F, Zillikens, M Carola, Amouyel, Philippe, Boehm, Bernhard O, Boerwinkle, Eric, Boomsma, Dorret I, Caulfield, Mark J, Chanock, Stephen J, Cupples, L Adrienne, Cusi, Daniele, Dedoussis, George V, Erdmann, Jeanette, Eriksson, Johan G, Franks, Paul W, Froguel, Philippe, Gieger, Christian, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B, Hengstenberg, Christian, Hicks, Andrew A, Hingorani, Aroon, Hinney, Anke, Hofman, Albert, Hovingh, Kees G, Hveem, Kristian, Illig, Thomas, Jarvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Keinanen-Kiukaanniemi, Sirkka M, Kiemeney, Lambertus A, Kuh, Diana, Laakso, Markku, Lehtimäki, Terho, Levinson, Douglas F, Martin, Nicholas G, Metspalu, Andres, Morris, Andrew D, Nieminen, Markku S, Njølstad, Inger, Ohlsson, Claes, Oldehinkel, Albertine J, Ouwehand, Willem H, Palmer, Lyle J, Penninx, Brenda, Power, Chris, Province, Michael A, Psaty, Bruce M, Qi, Lu, Rauramaa, Rainer, Ridker, Paul M, Ripatti, Samuli, Salomaa, Veikko, Samani, Nilesh J, Snieder, Harold, Sørensen, Thorkild I A, Spector, Timothy D, Stefansson, Kari, Tönjes, Anke, Tuomilehto, Jaakko, Uitterlinden, André G, Uusitupa, Matti, van der Harst, Pim, Vollenweider, Peter, Wallaschofski, Henri, Wareham, Nicholas J, Watkins, Hugh, Wichmann, H-Erich, Wilson, James, Abecasis, Goncalo R, Assimes, Themistocles L, Barroso, Inês, Boehnke, Michael, Borecki, Ingrid B, Deloukas, Panos, Fox, Caroline S, Frayling, Timothy, Groop, Leif C, Haritunian, Talin, Heid, Iris M, Hunter, David, Kaplan, Robert C, Karpe, Fredrik, Moffatt, Miriam F, Mohlke, Karen L, O'Connell, Jeffrey R, Pawitan, Yudi, Schadt, Eric E, Schlessinger, David, Steinthorsdottir, Valgerdur, Strachan, David P, Thorsteinsdottir, Unnur, van Duijn, Cornelia M, Visscher, Peter M, Di Blasio, Anna Maria, Hirschhorn, Joel N, Lindgren, Cecilia M, Morris, Andrew P, Meyre, David, Scherag, André, McCarthy, Mark I, Speliotes, Elizabeth K, North, Kari E, Loos, Ruth J F, Ingelsson, Erik, Berndt, Sonja I, Gustafsson, Stefan, Mägi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F, Justice, Anne E, Monda, Keri L, Croteau-Chonka, Damien C, Day, Felix R, Esko, Tõnu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U, Luan, Jian'an, Randall, Joshua C, Vedantam, Sailaja, Willer, Cristen J, Winkler, Thomas, Wood, Andrew R, Workalemahu, Tsegaselassie, Hu, Yi-Juan, Lee, Sang Hong, Liang, Liming, Lin, Dan-Yu, Min, Josine L, Neale, Benjamin M, Thorleifsson, Gudmar, Yang, Jian, Albrecht, Eva, Amin, Najaf, Bragg-Gresham, Jennifer L, Cadby, Gemma, den Heijer, Martin, Eklund, Niina, Fischer, Krista, Goel, Anuj, Hottenga, Jouke-Jan, Huffman, Jennifer E, Jarick, Ivonne, Johansson, Åsa, Johnson, Toby, Kanoni, Stavroula, Kleber, Marcus E, König, Inke R, Kristiansson, Kati, Kutalik, Zoltán, Lamina, Claudia, Lecoeur, Cecile, Li, Guo, Mangino, Massimo, McArdle, Wendy L, Medina-Gomez, Carolina, Müller-Nurasyid, Martina, Ngwa, Julius S, Nolte, Ilja M, Paternoster, Lavinia, Pechlivanis, Sonali, Perola, Markus, Peters, Marjolein J, Preuss, Michael, Rose, Lynda M, Shi, Jianxin, Shungin, Dmitry, Smith, Albert Vernon, Strawbridge, Rona J, Surakka, Ida, Teumer, Alexander, Trip, Mieke D, Tyrer, Jonathan, Van Vliet-Ostaptchouk, Jana V, Vandenput, Liesbeth, Waite, Lindsay L, Zhao, Jing Hua, Absher, Devin, Asselbergs, Folkert W, Atalay, Mustafa, Attwood, Antony P, Balmforth, Anthony J, Basart, Hanneke, Beilby, John, Bonnycastle, Lori L, Brambilla, Paolo, Bruinenberg, Marcel, Campbell, Harry, Chasman, Daniel I, Chines, Peter S, Collins, Francis S, Connell, John M, Cookson, William O, de Faire, Ulf, de Vegt, Femmie, Dei, Mariano, Dimitriou, Maria, Edkins, Sarah, Estrada, Karol, Evans, David M, Farrall, Martin, Ferrario, Marco M, Ferrières, Jean, Franke, Lude, Frau, Francesca, Gejman, Pablo V, Grallert, Harald, Grönberg, Henrik, Gudnason, Vilmundur, Hall, Alistair S, Hall, Per, Hartikainen, Anna-Liisa, Hayward, Caroline, Heard-Costa, Nancy L, Heath, Andrew C, Hebebrand, Johannes, Homuth, Georg, Hu, Frank B, Hunt, Sarah E, Hyppönen, Elina, Iribarren, Carlos, Jacobs, Kevin B, Jansson, John-Olov, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Kee, Frank, Khaw, Kay-Tee, Kivimäki, Mika, Koenig, Wolfgang, Kraja, Aldi T, Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Laitinen, Jaana H, Lakka, Timo A, Langenberg, Claudia, Launer, Lenore J, Lind, Lars, Lindström, Jaana, Liu, Jianjun, Liuzzi, Antonio, Lokki, Marja-Liisa, Lorentzon, Mattias, Madden, Pamela A, Magnusson, Patrik K, Manunta, Paolo, Marek, Diana, März, Winfried, Mateo Leach, Irene, McKnight, Barbara, Medland, Sarah E, Mihailov, Evelin, Milani, Lili, Montgomery, Grant W, Mooser, Vincent, Mühleisen, Thomas W, Munroe, Patricia B, Musk, Arthur W, Narisu, Narisu, Navis, Gerjan, Nicholson, George, Nohr, Ellen A, Ong, Ken K, Oostra, Ben A, Palmer, Colin N A, Palotie, Aarno, Peden, John F, Pedersen, Nancy, Peters, Annette, Polasek, Ozren, Pouta, Anneli, Pramstaller, Peter P, Prokopenko, Inga, Pütter, Carolin, Radhakrishnan, Aparna, Raitakari, Olli, Rendon, Augusto, Rivadeneira, Fernando, Rudan, Igor, Saaristo, Timo E, Sambrook, Jennifer G, Sanders, Alan R, Sanna, Serena, Saramies, Jouko, Schipf, Sabine, Schreiber, Stefan, Schunkert, Heribert, Shin, So-Youn, Signorini, Stefano, Sinisalo, Juha, Skrobek, Boris, Soranzo, Nicole, Stan?áková, Alena, Stark, Klaus, Stephens, Jonathan C, Stirrups, Kathleen, Stolk, Ronald P, Stumvoll, Michael, Swift, Amy J, Theodoraki, Eirini V, Thorand, Barbara, Tregouet, David-Alexandre, Tremoli, Elena, Van der Klauw, Melanie M, van Meurs, Joyce B J, Vermeulen, Sita H, Viikari, Jorma, Virtamo, Jarmo, Vitart, Veronique, Waeber, Gérard, Wang, Zhaoming, Widén, Elisabeth, Wild, Sarah H, Willemsen, Gonneke, Winkelmann, Bernhard R, Witteman, Jacqueline C M, Wolffenbuttel, Bruce H R, Wong, Andrew, Wright, Alan F, Zillikens, M Carola, Amouyel, Philippe, Boehm, Bernhard O, Boerwinkle, Eric, Boomsma, Dorret I, Caulfield, Mark J, Chanock, Stephen J, Cupples, L Adrienne, Cusi, Daniele, Dedoussis, George V, Erdmann, Jeanette, Eriksson, Johan G, Franks, Paul W, Froguel, Philippe, Gieger, Christian, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B, Hengstenberg, Christian, Hicks, Andrew A, Hingorani, Aroon, Hinney, Anke, Hofman, Albert, Hovingh, Kees G, Hveem, Kristian, Illig, Thomas, Jarvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Keinanen-Kiukaanniemi, Sirkka M, Kiemeney, Lambertus A, Kuh, Diana, Laakso, Markku, Lehtimäki, Terho, Levinson, Douglas F, Martin, Nicholas G, Metspalu, Andres, Morris, Andrew D, Nieminen, Markku S, Njølstad, Inger, Ohlsson, Claes, Oldehinkel, Albertine J, Ouwehand, Willem H, Palmer, Lyle J, Penninx, Brenda, Power, Chris, Province, Michael A, Psaty, Bruce M, Qi, Lu, Rauramaa, Rainer, Ridker, Paul M, Ripatti, Samuli, Salomaa, Veikko, Samani, Nilesh J, Snieder, Harold, Sørensen, Thorkild I A, Spector, Timothy D, Stefansson, Kari, Tönjes, Anke, Tuomilehto, Jaakko, Uitterlinden, André G, Uusitupa, Matti, van der Harst, Pim, Vollenweider, Peter, Wallaschofski, Henri, Wareham, Nicholas J, Watkins, Hugh, Wichmann, H-Erich, Wilson, James, Abecasis, Goncalo R, Assimes, Themistocles L, Barroso, Inês, Boehnke, Michael, Borecki, Ingrid B, Deloukas, Panos, Fox, Caroline S, Frayling, Timothy, Groop, Leif C, Haritunian, Talin, Heid, Iris M, Hunter, David, Kaplan, Robert C, Karpe, Fredrik, Moffatt, Miriam F, Mohlke, Karen L, O'Connell, Jeffrey R, Pawitan, Yudi, Schadt, Eric E, Schlessinger, David, Steinthorsdottir, Valgerdur, Strachan, David P, Thorsteinsdottir, Unnur, van Duijn, Cornelia M, Visscher, Peter M, Di Blasio, Anna Maria, Hirschhorn, Joel N, Lindgren, Cecilia M, Morris, Andrew P, Meyre, David, Scherag, André, McCarthy, Mark I, Speliotes, Elizabeth K, North, Kari E, Loos, Ruth J F, and Ingelsson, Erik
Published: 2013

43. A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus

Author: Oei, Ling, primary, Hsu, Yi-Hsiang, additional, Styrkarsdottir, Unnur, additional, Eussen, Bert H, additional, de Klein, Annelies, additional, Peters, Marjolein J, additional, Halldorsson, Bjarni, additional, Liu, Ching-Ti, additional, Alonso, Nerea, additional, Kaptoge, Stephen K, additional, Thorleifsson, Gudmar, additional, Hallmans, Göran, additional, Hocking, Lynne J, additional, Husted, Lise Bjerre, additional, Jameson, Karen A, additional, Kruk, Marcin, additional, Lewis, Joshua R, additional, Patel, Millan S, additional, Scollen, Serena, additional, Svensson, Olle, additional, Trompet, Stella, additional, van Schoor, Natasja M, additional, Zhu, Kun, additional, Buckley, Brendan M, additional, Cooper, Cyrus, additional, Ford, Ian, additional, Goltzman, David, additional, González-Macías, Jesús, additional, Langdahl, Bente Lomholt, additional, Leslie, William D, additional, Lips, Paul, additional, Lorenc, Roman S, additional, Olmos, José M, additional, Pettersson-Kymmer, Ulrika, additional, Reid, David M, additional, Riancho, José A, additional, Slagboom, P Eline, additional, Garcia-Ibarbia, Carmen, additional, Ingvarsson, Thorvaldur, additional, Johannsdottir, Hrefna, additional, Luben, Robert, additional, Medina-Gómez, Carolina, additional, Arp, Pascal, additional, Nandakumar, Kannabiran, additional, Palsson, Stefan Th, additional, Sigurdsson, Gunnar, additional, van Meurs, Joyce B J, additional, Zhou, Yanhua, additional, Hofman, Albert, additional, Jukema, J Wouter, additional, Pols, Huibert A P, additional, Prince, Richard L, additional, Cupples, L Adrienne, additional, Marshall, Christian R, additional, Pinto, Dalila, additional, Sato, Daisuke, additional, Scherer, Stephen W, additional, Reeve, Jonathan, additional, Thorsteinsdottir, Unnur, additional, Karasik, David, additional, Richards, J Brent, additional, Stefansson, Kari, additional, Uitterlinden, André G, additional, Ralston, Stuart H, additional, Ioannidis, John P A, additional, Kiel, Douglas P, additional, Rivadeneira, Fernando, additional, and Estrada, Karol, additional
Published: 2013
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44. Corrigendum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Author: Heid, Iris M, Jackson, Anne U, Randall, Joshua C, Winkler, Thomas W, Qi, Lu, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Zillikens, M Carola, Speliotes, Elizabeth K, Mägi, Reedik, Workalemahu, Tsegaselassie, White, Charles C, Bouatia-Naji, Nabila, Harris, Tamara B, Berndt, Sonja I, Ingelsson, Erik, Willer, Cristen J, Weedon, Michael N, Luan, Jian'an, Vedantam, Sailaja, Esko, Tõnu, Kilpeläinen, Tuomas O, Kutalik, Zoltán, Li, Shengxu, Monda, Keri L, Dixon, Anna L, Holmes, Christopher C, Kaplan, Lee M, Liang, Liming, Min, Josine L, Moffatt, Miriam F, Molony, Cliona, Nicholson, George, Schadt, Eric E, Zondervan, Krina T, Feitosa, Mary F, Ferreira, Teresa, Allen, Hana Lango, Weyant, Robert J, Wheeler, Eleanor, Wood, Andrew R, Estrada, Karol, Goddard, Michael E, Lettre, Guillaume, Mangino, Massimo, Nyholt, Dale R, Purcell, Shaun, Vernon Smith, Albert, Visscher, Peter M, Yang, Jian, McCarroll, Steven A, Nemesh, James, Voight, Benjamin F, Absher, Devin, Amin, Najaf, Aspelund, Thor, Coin, Lachlan, Glazer, Nicole L, Hayward, Caroline, Heard-Costa, Nancy L, Hottenga, Jouke-Jan, Johansson, Asa, Johnson, Toby, Kaakinen, Marika, Kapur, Karen, Ketkar, Shamika, Knowles, Joshua W, Kraft, Peter, Kraja, Aldi T, Lamina, Claudia, Leitzmann, Michael F, McKnight, Barbara, Morris, Andrew P, Ong, Ken K, Perry, John R B, Peters, Marjolein J, Polasek, Ozren, Prokopenko, Inga, Rayner, Nigel W, Ripatti, Samuli, Rivadeneira, Fernando, Robertson, Neil R, Sanna, Serena, Sovio, Ulla, Surakka, Ida, Teumer, Alexander, van Wingerden, Sophie, Vitart, Veronique, Zhao, Jing Hua, Cavalcanti-Proença, Christine, Chines, Peter S, Fisher, Eva, Kulzer, Jennifer R, Lecoeur, Cecile, Narisu, Narisu, Sandholt, Camilla, Scott, Laura J, Silander, Kaisa, Stark, Klaus, Tammesoo, Mari-Liis, Teslovich, Tanya M, Timpson, Nicholas John, Watanabe, Richard M, Welch, Ryan, Chasman, Daniel I, Cooper, Matthew N, Jansson, John-Olov, Kettunen, Johannes, Lawrence, Robert W, Pellikka, Niina, Perola, Markus, Vandenput, Liesbeth, Alavere, Helene, Almgren, Peter, Atwood, Larry D, Bennett, Amanda J, Biffar, Reiner, Bonnycastle, Lori L, Bornstein, Stefan R, Buchanan, Thomas A, Campbell, Harry, Day, Ian N M, Dei, Mariano, Dörr, Marcus, Elliott, Paul, Erdos, Michael R, Eriksson, Johan G, Freimer, Nelson B, Fu, Mao, Gaget, Stefan, Geus, Eco J C, Gjesing, Anette P, Grallert, Harald, Gräßler, Jürgen, Groves, Christopher J, Guiducci, Candace, Hartikainen, Anna-Liisa, Hassanali, Neelam, Havulinna, Aki S, Herzig, Karl-Heinz, Hicks, Andrew A, Hui, Jennie, Igl, Wilmar, Jousilahti, Pekka, Jula, Antti, Kajantie, Eero, Kinnunen, Leena, Kolcic, Ivana, Koskinen, Seppo, Kovacs, Peter, Kroemer, Heyo K, Krzelj, Vjekoslav, Kuusisto, Johanna, Kvaloy, Kirsti, Laitinen, Jaana, Lantieri, Olivier, Lathrop, G Mark, Lokki, Marja-Liisa, Luben, Robert N, Ludwig, Barbara, McArdle, Wendy L, McCarthy, Anne, Morken, Mario A, Nelis, Mari, Neville, Matt J, Paré, Guillaume, Parker, Alex N, Peden, John F, Pichler, Irene, Pietiläinen, Kirsi H, Platou, Carl G P, Pouta, Anneli, Ridderstråle, Martin, Samani, Nilesh J, Saramies, Jouko, Sinisalo, Juha, Smit, Jan H, Strawbridge, Rona J, Stringham, Heather M, Swift, Amy J, Teder-Laving, Maris, Thomson, Brian, Usala, Gianluca, van Meurs, Joyce B J, van Ommen, Gert-Jan, Vatin, Vincent, Volpato, Claudia B, Wallaschofski, Henri, Walters, G Bragi, Widen, Elisabeth, Wild, Sarah H, Willemsen, Gonneke, Witte, Daniel R, Zgaga, Lina, Zitting, Paavo, Beilby, John P, James, Alan L, Kähönen, Mika, Lehtimäki, Terho, Nieminen, Markku S, Ohlsson, Claes, Palmer, Lyle J, Raitakari, Olli, Ridker, Paul M, Stumvoll, Michael, Tönjes, Anke, Viikari, Jorma, Balkau, Beverley, Ben-Shlomo, Yoav, Bergman, Richard N, Boeing, Heiner, Smith, George Davey, Ebrahim, Shah, Froguel, Philippe, Hansen, Torben, Hengstenberg, Christian, Hveem, Kristian, Isomaa, Bo, Jørgensen, Torben, Karpe, Fredrik, Khaw, Kay-Tee, Laakso, Markku, Lawlor, Debbie A, Marre, Michel, Meitinger, Thomas, Metspalu, Andres, Midthjell, Kristian, Pedersen, Oluf, Salomaa, Veikko, Schwarz, Peter E H, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Valle, Timo T, Wareham, Nicholas J, Arnold, Alice M, Beckmann, Jacques S, Bergmann, Sven, Boerwinkle, Eric, Boomsma, Dorret I, Caulfield, Mark J, Collins, Francis S, Eiriksdottir, Gudny, Gudnason, Vilmundur, Gyllensten, Ulf, Hamsten, Anders, Hattersley, Andrew T, Hofman, Albert, Hu, Frank B, Illig, Thomas, Iribarren, Carlos, Jarvelin, Marjo-Riitta, Kao, W H Linda, Kaprio, Jaakko, Launer, Lenore J, Munroe, Patricia B, Oostra, Ben, Penninx, Brenda W, Pramstaller, Peter P, Psaty, Bruce M, Quertermous, Thomas, Rissanen, Aila, Rudan, Igor, Shuldiner, Alan R, Soranzo, Nicole, Spector, Timothy D, Syvanen, Ann-Christine, Uda, Manuela, Uitterlinden, André, Völzke, Henry, Vollenweider, Peter, Wilson, James F, Witteman, Jacqueline C, Wright, Alan F, Abecasis, Gonçalo R, Boehnke, Michael, Borecki, Ingrid B, Deloukas, Panos, Frayling, Timothy M, Groop, Leif C, Haritunians, Talin, Hunter, David J, Kaplan, Robert C, North, Kari E, O'Connell, Jeffrey R, Peltonen, Leena, Schlessinger, David, Strachan, David P, Hirschhorn, Joel N, Assimes, Themistocles L, Wichmann, H-Erich, Thorsteinsdottir, Unnur, van Duijn, Cornelia M, Stefansson, Kari, Cupples, L Adrienne, Loos, Ruth J F, Barroso, Inês, McCarthy, Mark I, Fox, Caroline S, Mohlke, Karen L, Lindgren, Cecilia M, Heid, Iris M, Jackson, Anne U, Randall, Joshua C, Winkler, Thomas W, Qi, Lu, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Zillikens, M Carola, Speliotes, Elizabeth K, Mägi, Reedik, Workalemahu, Tsegaselassie, White, Charles C, Bouatia-Naji, Nabila, Harris, Tamara B, Berndt, Sonja I, Ingelsson, Erik, Willer, Cristen J, Weedon, Michael N, Luan, Jian'an, Vedantam, Sailaja, Esko, Tõnu, Kilpeläinen, Tuomas O, Kutalik, Zoltán, Li, Shengxu, Monda, Keri L, Dixon, Anna L, Holmes, Christopher C, Kaplan, Lee M, Liang, Liming, Min, Josine L, Moffatt, Miriam F, Molony, Cliona, Nicholson, George, Schadt, Eric E, Zondervan, Krina T, Feitosa, Mary F, Ferreira, Teresa, Allen, Hana Lango, Weyant, Robert J, Wheeler, Eleanor, Wood, Andrew R, Estrada, Karol, Goddard, Michael E, Lettre, Guillaume, Mangino, Massimo, Nyholt, Dale R, Purcell, Shaun, Vernon Smith, Albert, Visscher, Peter M, Yang, Jian, McCarroll, Steven A, Nemesh, James, Voight, Benjamin F, Absher, Devin, Amin, Najaf, Aspelund, Thor, Coin, Lachlan, Glazer, Nicole L, Hayward, Caroline, Heard-Costa, Nancy L, Hottenga, Jouke-Jan, Johansson, Asa, Johnson, Toby, Kaakinen, Marika, Kapur, Karen, Ketkar, Shamika, Knowles, Joshua W, Kraft, Peter, Kraja, Aldi T, Lamina, Claudia, Leitzmann, Michael F, McKnight, Barbara, Morris, Andrew P, Ong, Ken K, Perry, John R B, Peters, Marjolein J, Polasek, Ozren, Prokopenko, Inga, Rayner, Nigel W, Ripatti, Samuli, Rivadeneira, Fernando, Robertson, Neil R, Sanna, Serena, Sovio, Ulla, Surakka, Ida, Teumer, Alexander, van Wingerden, Sophie, Vitart, Veronique, Zhao, Jing Hua, Cavalcanti-Proença, Christine, Chines, Peter S, Fisher, Eva, Kulzer, Jennifer R, Lecoeur, Cecile, Narisu, Narisu, Sandholt, Camilla, Scott, Laura J, Silander, Kaisa, Stark, Klaus, Tammesoo, Mari-Liis, Teslovich, Tanya M, Timpson, Nicholas John, Watanabe, Richard M, Welch, Ryan, Chasman, Daniel I, Cooper, Matthew N, Jansson, John-Olov, Kettunen, Johannes, Lawrence, Robert W, Pellikka, Niina, Perola, Markus, Vandenput, Liesbeth, Alavere, Helene, Almgren, Peter, Atwood, Larry D, Bennett, Amanda J, Biffar, Reiner, Bonnycastle, Lori L, Bornstein, Stefan R, Buchanan, Thomas A, Campbell, Harry, Day, Ian N M, Dei, Mariano, Dörr, Marcus, Elliott, Paul, Erdos, Michael R, Eriksson, Johan G, Freimer, Nelson B, Fu, Mao, Gaget, Stefan, Geus, Eco J C, Gjesing, Anette P, Grallert, Harald, Gräßler, Jürgen, Groves, Christopher J, Guiducci, Candace, Hartikainen, Anna-Liisa, Hassanali, Neelam, Havulinna, Aki S, Herzig, Karl-Heinz, Hicks, Andrew A, Hui, Jennie, Igl, Wilmar, Jousilahti, Pekka, Jula, Antti, Kajantie, Eero, Kinnunen, Leena, Kolcic, Ivana, Koskinen, Seppo, Kovacs, Peter, Kroemer, Heyo K, Krzelj, Vjekoslav, Kuusisto, Johanna, Kvaloy, Kirsti, Laitinen, Jaana, Lantieri, Olivier, Lathrop, G Mark, Lokki, Marja-Liisa, Luben, Robert N, Ludwig, Barbara, McArdle, Wendy L, McCarthy, Anne, Morken, Mario A, Nelis, Mari, Neville, Matt J, Paré, Guillaume, Parker, Alex N, Peden, John F, Pichler, Irene, Pietiläinen, Kirsi H, Platou, Carl G P, Pouta, Anneli, Ridderstråle, Martin, Samani, Nilesh J, Saramies, Jouko, Sinisalo, Juha, Smit, Jan H, Strawbridge, Rona J, Stringham, Heather M, Swift, Amy J, Teder-Laving, Maris, Thomson, Brian, Usala, Gianluca, van Meurs, Joyce B J, van Ommen, Gert-Jan, Vatin, Vincent, Volpato, Claudia B, Wallaschofski, Henri, Walters, G Bragi, Widen, Elisabeth, Wild, Sarah H, Willemsen, Gonneke, Witte, Daniel R, Zgaga, Lina, Zitting, Paavo, Beilby, John P, James, Alan L, Kähönen, Mika, Lehtimäki, Terho, Nieminen, Markku S, Ohlsson, Claes, Palmer, Lyle J, Raitakari, Olli, Ridker, Paul M, Stumvoll, Michael, Tönjes, Anke, Viikari, Jorma, Balkau, Beverley, Ben-Shlomo, Yoav, Bergman, Richard N, Boeing, Heiner, Smith, George Davey, Ebrahim, Shah, Froguel, Philippe, Hansen, Torben, Hengstenberg, Christian, Hveem, Kristian, Isomaa, Bo, Jørgensen, Torben, Karpe, Fredrik, Khaw, Kay-Tee, Laakso, Markku, Lawlor, Debbie A, Marre, Michel, Meitinger, Thomas, Metspalu, Andres, Midthjell, Kristian, Pedersen, Oluf, Salomaa, Veikko, Schwarz, Peter E H, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Valle, Timo T, Wareham, Nicholas J, Arnold, Alice M, Beckmann, Jacques S, Bergmann, Sven, Boerwinkle, Eric, Boomsma, Dorret I, Caulfield, Mark J, Collins, Francis S, Eiriksdottir, Gudny, Gudnason, Vilmundur, Gyllensten, Ulf, Hamsten, Anders, Hattersley, Andrew T, Hofman, Albert, Hu, Frank B, Illig, Thomas, Iribarren, Carlos, Jarvelin, Marjo-Riitta, Kao, W H Linda, Kaprio, Jaakko, Launer, Lenore J, Munroe, Patricia B, Oostra, Ben, Penninx, Brenda W, Pramstaller, Peter P, Psaty, Bruce M, Quertermous, Thomas, Rissanen, Aila, Rudan, Igor, Shuldiner, Alan R, Soranzo, Nicole, Spector, Timothy D, Syvanen, Ann-Christine, Uda, Manuela, Uitterlinden, André, Völzke, Henry, Vollenweider, Peter, Wilson, James F, Witteman, Jacqueline C, Wright, Alan F, Abecasis, Gonçalo R, Boehnke, Michael, Borecki, Ingrid B, Deloukas, Panos, Frayling, Timothy M, Groop, Leif C, Haritunians, Talin, Hunter, David J, Kaplan, Robert C, North, Kari E, O'Connell, Jeffrey R, Peltonen, Leena, Schlessinger, David, Strachan, David P, Hirschhorn, Joel N, Assimes, Themistocles L, Wichmann, H-Erich, Thorsteinsdottir, Unnur, van Duijn, Cornelia M, Stefansson, Kari, Cupples, L Adrienne, Loos, Ruth J F, Barroso, Inês, McCarthy, Mark I, Fox, Caroline S, Mohlke, Karen L, and Lindgren, Cecilia M
Published: 2011

45. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Author: Speliotes, Elizabeth K., Willer, Cristen J., Berndt, Sonja I., Monda, Keri L., Thorleifsson, Gudmar, Jackson, Anne U., Allen, Hana Lango, Lindgren, Cecilia M., Luan, Jian'an, Maegi, Reedik, Randall, Joshua C., Vedantam, Sailaja, Winkler, Thomas W., Qi, Lu, Workalemahu, Tsegaselassie, Heid, Iris M., Steinthorsdottir, Valgerdur, Stringham, Heather M., Weedon, Michael N., Wheeler, Eleanor, Wood, Andrew R., Ferreira, Teresa, Weyant, Robert J., Segre, Ayellet V., Estrada, Karol, Liang, Liming, Nemesh, James, Park, Ju-Hyun, Gustafsson, Stefan, Kilpelaenen, Tuomas O., Yang, Jian, Bouatia-Naji, Nabila, Esko, Tonu, Feitosa, Mary F., Kutalik, Zoltan, Mangino, Massimo, Raychaudhuri, Soumya, Scherag, Andre, Smith, Albert Vernon, Welch, Ryan, Zhao, Jing Hua, Aben, Katja K., Absher, Devin M., Amin, Najaf, Dixon, Anna L., Fisher, Eva, Glazer, Nicole L., Goddard, Michael E., Heard-Costa, Nancy L., Hoesel, Volker, Hottenga, Jouke-Jan, Johansson, Åsa, Johnson, Toby, Ketkar, Shamika, Lamina, Claudia, Li, Shengxu, Moffatt, Miriam F., Myers, Richard H., Narisu, Narisu, Perry, John R. B., Peters, Marjolein J., Preuss, Michael, Ripatti, Samuli, Rivadeneira, Fernando, Sandholt, Camilla, Scott, Laura J., Timpson, Nicholas J., Tyrer, Jonathan P., van Wingerden, Sophie, Watanabe, Richard M., White, Charles C., Wiklund, Fredrik, Barlassina, Christina, Chasman, Daniel I., Cooper, Matthew N., Jansson, John-Olov, Lawrence, Robert W., Pellikka, Niina, Prokopenko, Inga, Shi, Jianxin, Thiering, Elisabeth, Alavere, Helene, Alibrandi, Maria T. S., Almgren, Peter, Arnold, Alice M., Aspelund, Thor, Atwood, Larry D., Balkau, Beverley, Balmforth, Anthony J., Bennett, Amanda J., Ben-Shlomo, Yoav, Bergman, Richard N., Bergmann, Sven, Biebermann, Heike, Blakemore, Alexandra I. F., Boes, Tanja, Bonnycastle, Lori L., Bornstein, Stefan R., Brown, Morris J., Buchanan, Thomas A., Busonero, Fabio, Campbell, Harry, Cappuccio, Francesco P., Cavalcanti-Proenca, Christine, Chen, Yii-Der Ida, Chen, Chih-Mei, Chines, Peter S., Clarke, Robert, Coin, Lachlan, Connell, John, Day, Ian N. M., den Heijer, Martin, Duan, Jubao, Ebrahim, Shah, Elliott, Paul, Elosua, Roberto, Eiriksdottir, Gudny, Erdos, Michael R., Eriksson, Johan G., Facheris, Maurizio F., Felix, Stephan B., Fischer-Posovszky, Pamela, Folsom, Aaron R., Friedrich, Nele, Freimer, Nelson B., Fu, Mao, Gaget, Stefan, Gejman, Pablo V., Geus, Eco J. C., Gieger, Christian, Gjesing, Anette P., Goel, Anuj, Goyette, Philippe, Grallert, Harald, Graessler, Juergen, Greenawalt, Danielle M., Groves, Christopher J., Gudnason, Vilmundur, Guiducci, Candace, Hartikainen, Anna-Liisa, Hassanali, Neelam, Hall, Alistair S., Havulinna, Aki S., Hayward, Caroline, Heath, Andrew C., Hengstenberg, Christian, Hicks, Andrew A., Hinney, Anke, Hofman, Albert, Homuth, Georg, Hui, Jennie, Igl, Wilmar, Iribarren, Carlos, Isomaa, Bo, Jacobs, Kevin B., Jarick, Ivonne, Jewell, Elizabeth, John, Ulrich, Jorgensen, Torben, Jousilahti, Pekka, Jula, Antti, Kaakinen, Marika, Kajantie, Eero, Kaplan, Lee M., Kathiresan, Sekar, Kettunen, Johannes, Kinnunen, Leena, Knowles, Joshua W., Kolcic, Ivana, Koenig, Inke R., Koskinen, Seppo, Kovacs, Peter, Kuusisto, Johanna, Kraft, Peter, Kvaloy, Kirsti, Laitinen, Jaana, Lantieri, Olivier, Lanzani, Chiara, Launer, Lenore J., Lecoeur, Cecile, Lehtimaeki, Terho, Lettre, Guillaume, Liu, Jianjun, Lokki, Marja-Liisa, Lorentzon, Mattias, Luben, Robert N., Ludwig, Barbara, Manunta, Paolo, Marek, Diana, Marre, Michel, Martin, Nicholas G., McArdle, Wendy L., McCarthy, Anne, McKnight, Barbara, Meitinger, Thomas, Melander, Olle, Meyre, David, Midthjell, Kristian, Montgomery, Grant W., Morken, Mario A., Morris, Andrew P., Mulic, Rosanda, Ngwa, Julius S., Nelis, Mari, Neville, Matt J., Nyholt, Dale R., O'Donnell, Christopher J., O'Rahilly, Stephen, Ong, Ken K., Oostra, Ben, Pare, Guillaume, Parker, Alex N., Perola, Markus, Pichler, Irene, Pietilaeinen, Kirsi H., Platou, Carl G. P., Polasek, Ozren, Pouta, Anneli, Rafelt, Suzanne, Raitakari, Olli, Rayner, Nigel W., Ridderstrale, Martin, Rief, Winfried, Ruokonen, Aimo, Robertson, Neil R., Rzehak, Peter, Salomaa, Veikko, Sanders, Alan R., Sandhu, Manjinder S., Sanna, Serena, Saramies, Jouko, Savolainen, Markku J., Scherag, Susann, Schipf, Sabine, Schreiber, Stefan, Schunkert, Heribert, Silander, Kaisa, Sinisalo, Juha, Siscovick, David S., Smit, Jan H., Soranzo, Nicole, Sovio, Ulla, Stephens, Jonathan, Surakka, Ida, Swift, Amy J., Tammesoo, Mari-Liis, Tardif, Jean-Claude, Teder-Laving, Maris, Teslovich, Tanya M., Thompson, John R., Thomson, Brian, Toenjes, Anke, Tuomi, Tiinamaija, van Meurs, Joyce B. J., van Ommen, Gert-Jan, Vatin, Vincent, Viikari, Jorma, Visvikis-Siest, Sophie, Vitart, Veronique, Vogel, Carla I. G., Voight, Benjamin F., Waite, Lindsay L., Wallaschofski, Henri, Walters, G. Bragi, Widen, Elisabeth, Wiegand, Susanna, Wild, Sarah H., Willemsen, Gonneke, Witte, Daniel R., Witteman, Jacqueline C., Xu, Jianfeng, Zhang, Qunyuan, Zgaga, Lina, Ziegler, Andreas, Zitting, Paavo, Beilby, John P., Farooqi, I. Sadaf, Hebebrand, Johannes, Huikuri, Heikki V., James, Alan L., Kaehoenen, Mika, Levinson, Douglas F., Macciardi, Fabio, Nieminen, Markku S., Ohlsson, Claes, Palmer, Lyle J., Ridker, Paul M., Stumvoll, Michael, Beckmann, Jacques S., Boeing, Heiner, Boerwinkle, Eric, Boomsma, Dorret I., Caulfield, Mark J., Chanock, Stephen J., Collins, Francis S., Cupples, L. Adrienne, Smith, George Davey, Erdmann, Jeanette, Froguel, Philippe, Greonberg, Henrik, Gyllensten, Ulf, Hall, Per, Hansen, Torben, Harris, Tamara B., Hattersley, Andrew T., Hayes, Richard B., Heinrich, Joachim, Hu, Frank B., Hveem, Kristian, Illig, Thomas, Jarvelin, Marjo-Riitta, Kaprio, Jaakko, Karpe, Fredrik, Khaw, Kay-Tee, Kiemeney, Lambertus A., Krude, Heiko, Laakso, Markku, Lawlor, Debbie A., Metspalu, Andres, Munroe, Patricia B., Ouwehand, Willem H., Pedersen, Oluf, Penninx, Brenda W., Peters, Annette, Pramstaller, Peter P., Quertermous, Thomas, Reinehr, Thomas, Rissanen, Aila, Rudan, Igor, Samani, Nilesh J., Schwarz, Peter E. H., Shuldiner, Alan R., Spector, Timothy D., Tuomilehto, Jaakko, Uda, Manuela, Uitterlinden, Andre, Valle, Timo T., Wabitsch, Martin, Waeber, Gerard, Wareham, Nicholas J., Watkins, Hugh, Wilson, James F., Wright, Alan F., Zillikens, M. Carola, Chatterjee, Nilanjan, McCarroll, Steven A., Purcell, Shaun, Schadt, Eric E., Visscher, Peter M., Assimes, Themistocles L., Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Groop, Leif C., Haritunians, Talin, Hunter, David J., Kaplan, Robert C., Mohlke, Karen L., O'Connell, Jeffrey R., Peltonen, Leena, Schlessinger, David, Strachan, David P., van Duijn, Cornelia M., Wichmann, H-Erich, Frayling, Timothy M., Thorsteinsdottir, Unnur, Abecasis, Goncalo R., Barroso, Ines, Boehnke, Michael, Stefansson, Kari, North, Kari E., McCarthy, Mark I., Hirschhorn, Joel N., Ingelsson, Erik, Loos, Ruth J. F., Speliotes, Elizabeth K., Willer, Cristen J., Berndt, Sonja I., Monda, Keri L., Thorleifsson, Gudmar, Jackson, Anne U., Allen, Hana Lango, Lindgren, Cecilia M., Luan, Jian'an, Maegi, Reedik, Randall, Joshua C., Vedantam, Sailaja, Winkler, Thomas W., Qi, Lu, Workalemahu, Tsegaselassie, Heid, Iris M., Steinthorsdottir, Valgerdur, Stringham, Heather M., Weedon, Michael N., Wheeler, Eleanor, Wood, Andrew R., Ferreira, Teresa, Weyant, Robert J., Segre, Ayellet V., Estrada, Karol, Liang, Liming, Nemesh, James, Park, Ju-Hyun, Gustafsson, Stefan, Kilpelaenen, Tuomas O., Yang, Jian, Bouatia-Naji, Nabila, Esko, Tonu, Feitosa, Mary F., Kutalik, Zoltan, Mangino, Massimo, Raychaudhuri, Soumya, Scherag, Andre, Smith, Albert Vernon, Welch, Ryan, Zhao, Jing Hua, Aben, Katja K., Absher, Devin M., Amin, Najaf, Dixon, Anna L., Fisher, Eva, Glazer, Nicole L., Goddard, Michael E., Heard-Costa, Nancy L., Hoesel, Volker, Hottenga, Jouke-Jan, Johansson, Åsa, Johnson, Toby, Ketkar, Shamika, Lamina, Claudia, Li, Shengxu, Moffatt, Miriam F., Myers, Richard H., Narisu, Narisu, Perry, John R. B., Peters, Marjolein J., Preuss, Michael, Ripatti, Samuli, Rivadeneira, Fernando, Sandholt, Camilla, Scott, Laura J., Timpson, Nicholas J., Tyrer, Jonathan P., van Wingerden, Sophie, Watanabe, Richard M., White, Charles C., Wiklund, Fredrik, Barlassina, Christina, Chasman, Daniel I., Cooper, Matthew N., Jansson, John-Olov, Lawrence, Robert W., Pellikka, Niina, Prokopenko, Inga, Shi, Jianxin, Thiering, Elisabeth, Alavere, Helene, Alibrandi, Maria T. S., Almgren, Peter, Arnold, Alice M., Aspelund, Thor, Atwood, Larry D., Balkau, Beverley, Balmforth, Anthony J., Bennett, Amanda J., Ben-Shlomo, Yoav, Bergman, Richard N., Bergmann, Sven, Biebermann, Heike, Blakemore, Alexandra I. F., Boes, Tanja, Bonnycastle, Lori L., Bornstein, Stefan R., Brown, Morris J., Buchanan, Thomas A., Busonero, Fabio, Campbell, Harry, Cappuccio, Francesco P., Cavalcanti-Proenca, Christine, Chen, Yii-Der Ida, Chen, Chih-Mei, Chines, Peter S., Clarke, Robert, Coin, Lachlan, Connell, John, Day, Ian N. M., den Heijer, Martin, Duan, Jubao, Ebrahim, Shah, Elliott, Paul, Elosua, Roberto, Eiriksdottir, Gudny, Erdos, Michael R., Eriksson, Johan G., Facheris, Maurizio F., Felix, Stephan B., Fischer-Posovszky, Pamela, Folsom, Aaron R., Friedrich, Nele, Freimer, Nelson B., Fu, Mao, Gaget, Stefan, Gejman, Pablo V., Geus, Eco J. C., Gieger, Christian, Gjesing, Anette P., Goel, Anuj, Goyette, Philippe, Grallert, Harald, Graessler, Juergen, Greenawalt, Danielle M., Groves, Christopher J., Gudnason, Vilmundur, Guiducci, Candace, Hartikainen, Anna-Liisa, Hassanali, Neelam, Hall, Alistair S., Havulinna, Aki S., Hayward, Caroline, Heath, Andrew C., Hengstenberg, Christian, Hicks, Andrew A., Hinney, Anke, Hofman, Albert, Homuth, Georg, Hui, Jennie, Igl, Wilmar, Iribarren, Carlos, Isomaa, Bo, Jacobs, Kevin B., Jarick, Ivonne, Jewell, Elizabeth, John, Ulrich, Jorgensen, Torben, Jousilahti, Pekka, Jula, Antti, Kaakinen, Marika, Kajantie, Eero, Kaplan, Lee M., Kathiresan, Sekar, Kettunen, Johannes, Kinnunen, Leena, Knowles, Joshua W., Kolcic, Ivana, Koenig, Inke R., Koskinen, Seppo, Kovacs, Peter, Kuusisto, Johanna, Kraft, Peter, Kvaloy, Kirsti, Laitinen, Jaana, Lantieri, Olivier, Lanzani, Chiara, Launer, Lenore J., Lecoeur, Cecile, Lehtimaeki, Terho, Lettre, Guillaume, Liu, Jianjun, Lokki, Marja-Liisa, Lorentzon, Mattias, Luben, Robert N., Ludwig, Barbara, Manunta, Paolo, Marek, Diana, Marre, Michel, Martin, Nicholas G., McArdle, Wendy L., McCarthy, Anne, McKnight, Barbara, Meitinger, Thomas, Melander, Olle, Meyre, David, Midthjell, Kristian, Montgomery, Grant W., Morken, Mario A., Morris, Andrew P., Mulic, Rosanda, Ngwa, Julius S., Nelis, Mari, Neville, Matt J., Nyholt, Dale R., O'Donnell, Christopher J., O'Rahilly, Stephen, Ong, Ken K., Oostra, Ben, Pare, Guillaume, Parker, Alex N., Perola, Markus, Pichler, Irene, Pietilaeinen, Kirsi H., Platou, Carl G. P., Polasek, Ozren, Pouta, Anneli, Rafelt, Suzanne, Raitakari, Olli, Rayner, Nigel W., Ridderstrale, Martin, Rief, Winfried, Ruokonen, Aimo, Robertson, Neil R., Rzehak, Peter, Salomaa, Veikko, Sanders, Alan R., Sandhu, Manjinder S., Sanna, Serena, Saramies, Jouko, Savolainen, Markku J., Scherag, Susann, Schipf, Sabine, Schreiber, Stefan, Schunkert, Heribert, Silander, Kaisa, Sinisalo, Juha, Siscovick, David S., Smit, Jan H., Soranzo, Nicole, Sovio, Ulla, Stephens, Jonathan, Surakka, Ida, Swift, Amy J., Tammesoo, Mari-Liis, Tardif, Jean-Claude, Teder-Laving, Maris, Teslovich, Tanya M., Thompson, John R., Thomson, Brian, Toenjes, Anke, Tuomi, Tiinamaija, van Meurs, Joyce B. J., van Ommen, Gert-Jan, Vatin, Vincent, Viikari, Jorma, Visvikis-Siest, Sophie, Vitart, Veronique, Vogel, Carla I. G., Voight, Benjamin F., Waite, Lindsay L., Wallaschofski, Henri, Walters, G. Bragi, Widen, Elisabeth, Wiegand, Susanna, Wild, Sarah H., Willemsen, Gonneke, Witte, Daniel R., Witteman, Jacqueline C., Xu, Jianfeng, Zhang, Qunyuan, Zgaga, Lina, Ziegler, Andreas, Zitting, Paavo, Beilby, John P., Farooqi, I. Sadaf, Hebebrand, Johannes, Huikuri, Heikki V., James, Alan L., Kaehoenen, Mika, Levinson, Douglas F., Macciardi, Fabio, Nieminen, Markku S., Ohlsson, Claes, Palmer, Lyle J., Ridker, Paul M., Stumvoll, Michael, Beckmann, Jacques S., Boeing, Heiner, Boerwinkle, Eric, Boomsma, Dorret I., Caulfield, Mark J., Chanock, Stephen J., Collins, Francis S., Cupples, L. Adrienne, Smith, George Davey, Erdmann, Jeanette, Froguel, Philippe, Greonberg, Henrik, Gyllensten, Ulf, Hall, Per, Hansen, Torben, Harris, Tamara B., Hattersley, Andrew T., Hayes, Richard B., Heinrich, Joachim, Hu, Frank B., Hveem, Kristian, Illig, Thomas, Jarvelin, Marjo-Riitta, Kaprio, Jaakko, Karpe, Fredrik, Khaw, Kay-Tee, Kiemeney, Lambertus A., Krude, Heiko, Laakso, Markku, Lawlor, Debbie A., Metspalu, Andres, Munroe, Patricia B., Ouwehand, Willem H., Pedersen, Oluf, Penninx, Brenda W., Peters, Annette, Pramstaller, Peter P., Quertermous, Thomas, Reinehr, Thomas, Rissanen, Aila, Rudan, Igor, Samani, Nilesh J., Schwarz, Peter E. H., Shuldiner, Alan R., Spector, Timothy D., Tuomilehto, Jaakko, Uda, Manuela, Uitterlinden, Andre, Valle, Timo T., Wabitsch, Martin, Waeber, Gerard, Wareham, Nicholas J., Watkins, Hugh, Wilson, James F., Wright, Alan F., Zillikens, M. Carola, Chatterjee, Nilanjan, McCarroll, Steven A., Purcell, Shaun, Schadt, Eric E., Visscher, Peter M., Assimes, Themistocles L., Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Groop, Leif C., Haritunians, Talin, Hunter, David J., Kaplan, Robert C., Mohlke, Karen L., O'Connell, Jeffrey R., Peltonen, Leena, Schlessinger, David, Strachan, David P., van Duijn, Cornelia M., Wichmann, H-Erich, Frayling, Timothy M., Thorsteinsdottir, Unnur, Abecasis, Goncalo R., Barroso, Ines, Boehnke, Michael, Stefansson, Kari, North, Kari E., McCarthy, Mark I., Hirschhorn, Joel N., Ingelsson, Erik, and Loos, Ruth J. F.
Abstract: Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation., De sju sista författarna delar sistaförfattarskapet.
Published: 2010
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46. Hundreds of variants clustered in genomic loci and biological pathways affect human height

Author: Allen, Hana Lango, Estrada, Karol, Lettre, Guillaume, Berndt, Sonja I., Weedon, Michael N., Rivadeneira, Fernando, Willer, Cristen J., Jackson, Anne U., Vedantam, Sailaja, Raychaudhuri, Soumya, Ferreira, Teresa, Wood, Andrew R., Weyant, Robert J., Segre, Ayellet V., Speliotes, Elizabeth K., Wheeler, Eleanor, Soranzo, Nicole, Park, Ju-Hyun, Yang, Jian, Gudbjartsson, Daniel, Heard-Costa, Nancy L., Randall, Joshua C., Qi, Lu, Smith, Albert Vernon, Maegi, Reedik, Pastinen, Tomi, Liang, Liming, Heid, Iris M., Luan, Jian'an, Thorleifsson, Gudmar, Winkler, Thomas W., Goddard, Michael E., Lo, Ken Sin, Palmer, Cameron, Workalemahu, Tsegaselassie, Aulchenko, Yurii S., Johansson, Åsa, Zillikens, M. Carola, Feitosa, Mary F., Esko, Tonu, Johnson, Toby, Ketkar, Shamika, Kraft, Peter, Mangino, Massimo, Prokopenko, Inga, Absher, Devin, Albrecht, Eva, Ernst, Florian, Glazer, Nicole L., Hayward, Caroline, Hottenga, Jouke-Jan, Jacobs, Kevin B., Knowles, Joshua W., Kutalik, Zoltan, Monda, Keri L., Polasek, Ozren, Preuss, Michael, Rayner, Nigel W., Robertson, Neil R., Steinthorsdottir, Valgerdur, Tyrer, Jonathan P., Voight, Benjamin F., Wiklund, Fredrik, Xu, Jianfeng, Zhao, Jing Hua, Nyholt, Dale R., Pellikka, Niina, Perola, Markus, Perry, John R. B., Surakka, Ida, Tammesoo, Mari-Liis, Altmaier, Elizabeth L., Amin, Najaf, Aspelund, Thor, Bhangale, Tushar, Boucher, Gabrielle, Chasman, Daniel I., Chen, Constance, Coin, Lachlan, Cooper, Matthew N., Dixon, Anna L., Gibson, Quince, Grundberg, Elin, Hao, Ke, Junttila, M. Juhani, Kaplan, Lee M., Kettunen, Johannes, Koenig, Inke R., Kwan, Tony, Lawrence, Robert W., Levinson, Douglas F., Lorentzon, Mattias, McKnight, Barbara, Morris, Andrew P., Mueller, Martina, Ngwa, Julius Suh, Purcell, Shaun, Rafelt, Suzanne, Salem, Rany M., Salvi, Erika, Sanna, Serena, Shi, Jianxin, Sovio, Ulla, Thompson, John R., Turchin, Michael C., Vandenput, Liesbeth, Verlaan, Dominique J., Vitart, Veronique, White, Charles C., Ziegler, Andreas, Almgren, Peter, Balmforth, Anthony J., Campbell, Harry, Citterio, Lorena, De Grandi, Alessandro, Dominiczak, Anna, Duan, Jubao, Elliott, Paul, Elosua, Roberto, Eriksson, Johan G., Freimer, Nelson B., Geus, Eco J. C., Glorioso, Nicola, Haiqing, Shen, Hartikainen, Anna-Liisa, Havulinna, Aki S., Hicks, Andrew A., Hui, Jennie, Igl, Wilmar, Illig, Thomas, Jula, Antti, Kajantie, Eero, Kilpelaeinen, Tuomas O., Koiranen, Markku, Kolcic, Ivana, Koskinen, Seppo, Kovacs, Peter, Laitinen, Jaana, Liu, Jianjun, Lokki, Marja-Liisa, Marusic, Ana, Maschio, Andrea, Meitinger, Thomas, Mulas, Antonella, Pare, Guillaume, Parker, Alex N., Peden, John F., Petersmann, Astrid, Pichler, Irene, Pietilainen, Kirsi H., Pouta, Anneli, Riddertrale, Martin, Rotter, Jerome I., Sambrook, Jennifer G., Sanders, Alan R., Schmidt, Carsten Oliver, Sinisalo, Juha, Smit, Jan H., Stringham, Heather M., Walters, G. Bragi, Widen, Elisabeth, Wild, Sarah H., Willemsen, Gonneke, Zagato, Laura, Zgaga, Lina, Zitting, Paavo, Alavere, Helene, Farrall, Martin, McArdle, Wendy L., Nelis, Mari, Peters, Marjolein J., Ripatti, Samuli, vVan Meurs, Joyce B. J., Aben, Katja K., Ardlie, Kristin G., Beckmann, Jacques S., Beilby, John P., Bergman, Richard N., Bergmann, Sven, Collins, Francis S., Cusi, Daniele, den Heijer, Martin, Eiriksdottir, Gudny, Gejman, Pablo V., Hall, Alistair S., Hamsten, Anders, Huikuri, Heikki V., Iribarren, Carlos, Kahonen, Mika, Kaprio, Jaakko, Kathiresan, Sekar, Kiemeney, Lambertus, Kocher, Thomas, Launer, Lenore J., Lehtimaki, Terho, Melander, Olle, Mosley, Tom H., Jr., Musk, Arthur W., Nieminen, Markku S., O'Donnell, Christopher J., Ohlsson, Claes, Oostra, Ben, Palmer, Lyle J., Raitakari, Olli, Ridker, Paul M., Rioux, John D., Rissanen, Aila, Rivolta, Carlo, Schunkert, Heribert, Shuldiner, Alan R., Siscovick, David S., Stumvoll, Michael, Toenjes, Anke, Tuomilehto, Jaakko, van Ommen, Gert-Jan, Viikari, Jorma, Heath, Andrew C., Martin, Nicholas G., Montgomery, Grant W., Province, Michael A., Kayser, Manfred, Arnold, Alice M., Atwood, Larry D., Boerwinkle, Eric, Chanock, Stephen J., Deloukas, Panos, Gieger, Christian, Gronberg, Henrik, Hall, Per, Hattersley, Andrew T., Hengstenberg, Christian, Hoffman, Wolfgang, Lathrop, G. Mark, Salomaa, Veikko, Schreiber, Stefan, Uda, Manuela, Waterworth, Dawn, Wright, Alan F., Assimes, Themistocles L., Barroso, Ines, Hofman, Albert, Mohlke, Karen L., Boomsma, Dorret I., Caulfield, Mark J., Cupples, L. Adrienne, Erdmann, Jeanette, Fox, Caroline S., Gudnason, Vilmundur, Gyllensten, Ulf, Harris, Tamara B., Hayes, Richard B., Jarvelin, Marjo-Ritta, Mooser, Vincent, Munroe, Patricia B., Ouwehand, Willem H., Penninx, Brenda W., Pramstaller, Peter P., Quertermous, Thomas, Rudan, Igor, Samani, Nilesh J., Spector, Timothy D., Voelzke, Henry, Watkins, Hugh, Wilson, James F., Groop, Leif C., Haritunians, Talin, Hu, Frank B., Kaplan, Robert C., Metspalu, Andres, North, Kari E., Schlessinger, David, Wareham, Nicholas J., Hunter, David J., O'Connell, Jeffrey R., Strachan, David P., Schadt, H. -Erich, Thorsteinsdottir, Unnur, Peltonen, Leena, Uitterlinden, Andre G., Visscher, Peter M., Chatterjee, Nilanjan, Loos, Ruth J. F., Boehnke, Michael, McCarthy, Mark I., Ingelsson, Erik, Lindgren, Cecilia M., Abecasis, Goncalo R., Stefansson, Kari, Frayling, Timothy M., Hirschhorn, Joel N., Allen, Hana Lango, Estrada, Karol, Lettre, Guillaume, Berndt, Sonja I., Weedon, Michael N., Rivadeneira, Fernando, Willer, Cristen J., Jackson, Anne U., Vedantam, Sailaja, Raychaudhuri, Soumya, Ferreira, Teresa, Wood, Andrew R., Weyant, Robert J., Segre, Ayellet V., Speliotes, Elizabeth K., Wheeler, Eleanor, Soranzo, Nicole, Park, Ju-Hyun, Yang, Jian, Gudbjartsson, Daniel, Heard-Costa, Nancy L., Randall, Joshua C., Qi, Lu, Smith, Albert Vernon, Maegi, Reedik, Pastinen, Tomi, Liang, Liming, Heid, Iris M., Luan, Jian'an, Thorleifsson, Gudmar, Winkler, Thomas W., Goddard, Michael E., Lo, Ken Sin, Palmer, Cameron, Workalemahu, Tsegaselassie, Aulchenko, Yurii S., Johansson, Åsa, Zillikens, M. Carola, Feitosa, Mary F., Esko, Tonu, Johnson, Toby, Ketkar, Shamika, Kraft, Peter, Mangino, Massimo, Prokopenko, Inga, Absher, Devin, Albrecht, Eva, Ernst, Florian, Glazer, Nicole L., Hayward, Caroline, Hottenga, Jouke-Jan, Jacobs, Kevin B., Knowles, Joshua W., Kutalik, Zoltan, Monda, Keri L., Polasek, Ozren, Preuss, Michael, Rayner, Nigel W., Robertson, Neil R., Steinthorsdottir, Valgerdur, Tyrer, Jonathan P., Voight, Benjamin F., Wiklund, Fredrik, Xu, Jianfeng, Zhao, Jing Hua, Nyholt, Dale R., Pellikka, Niina, Perola, Markus, Perry, John R. B., Surakka, Ida, Tammesoo, Mari-Liis, Altmaier, Elizabeth L., Amin, Najaf, Aspelund, Thor, Bhangale, Tushar, Boucher, Gabrielle, Chasman, Daniel I., Chen, Constance, Coin, Lachlan, Cooper, Matthew N., Dixon, Anna L., Gibson, Quince, Grundberg, Elin, Hao, Ke, Junttila, M. Juhani, Kaplan, Lee M., Kettunen, Johannes, Koenig, Inke R., Kwan, Tony, Lawrence, Robert W., Levinson, Douglas F., Lorentzon, Mattias, McKnight, Barbara, Morris, Andrew P., Mueller, Martina, Ngwa, Julius Suh, Purcell, Shaun, Rafelt, Suzanne, Salem, Rany M., Salvi, Erika, Sanna, Serena, Shi, Jianxin, Sovio, Ulla, Thompson, John R., Turchin, Michael C., Vandenput, Liesbeth, Verlaan, Dominique J., Vitart, Veronique, White, Charles C., Ziegler, Andreas, Almgren, Peter, Balmforth, Anthony J., Campbell, Harry, Citterio, Lorena, De Grandi, Alessandro, Dominiczak, Anna, Duan, Jubao, Elliott, Paul, Elosua, Roberto, Eriksson, Johan G., Freimer, Nelson B., Geus, Eco J. C., Glorioso, Nicola, Haiqing, Shen, Hartikainen, Anna-Liisa, Havulinna, Aki S., Hicks, Andrew A., Hui, Jennie, Igl, Wilmar, Illig, Thomas, Jula, Antti, Kajantie, Eero, Kilpelaeinen, Tuomas O., Koiranen, Markku, Kolcic, Ivana, Koskinen, Seppo, Kovacs, Peter, Laitinen, Jaana, Liu, Jianjun, Lokki, Marja-Liisa, Marusic, Ana, Maschio, Andrea, Meitinger, Thomas, Mulas, Antonella, Pare, Guillaume, Parker, Alex N., Peden, John F., Petersmann, Astrid, Pichler, Irene, Pietilainen, Kirsi H., Pouta, Anneli, Riddertrale, Martin, Rotter, Jerome I., Sambrook, Jennifer G., Sanders, Alan R., Schmidt, Carsten Oliver, Sinisalo, Juha, Smit, Jan H., Stringham, Heather M., Walters, G. Bragi, Widen, Elisabeth, Wild, Sarah H., Willemsen, Gonneke, Zagato, Laura, Zgaga, Lina, Zitting, Paavo, Alavere, Helene, Farrall, Martin, McArdle, Wendy L., Nelis, Mari, Peters, Marjolein J., Ripatti, Samuli, vVan Meurs, Joyce B. J., Aben, Katja K., Ardlie, Kristin G., Beckmann, Jacques S., Beilby, John P., Bergman, Richard N., Bergmann, Sven, Collins, Francis S., Cusi, Daniele, den Heijer, Martin, Eiriksdottir, Gudny, Gejman, Pablo V., Hall, Alistair S., Hamsten, Anders, Huikuri, Heikki V., Iribarren, Carlos, Kahonen, Mika, Kaprio, Jaakko, Kathiresan, Sekar, Kiemeney, Lambertus, Kocher, Thomas, Launer, Lenore J., Lehtimaki, Terho, Melander, Olle, Mosley, Tom H., Jr., Musk, Arthur W., Nieminen, Markku S., O'Donnell, Christopher J., Ohlsson, Claes, Oostra, Ben, Palmer, Lyle J., Raitakari, Olli, Ridker, Paul M., Rioux, John D., Rissanen, Aila, Rivolta, Carlo, Schunkert, Heribert, Shuldiner, Alan R., Siscovick, David S., Stumvoll, Michael, Toenjes, Anke, Tuomilehto, Jaakko, van Ommen, Gert-Jan, Viikari, Jorma, Heath, Andrew C., Martin, Nicholas G., Montgomery, Grant W., Province, Michael A., Kayser, Manfred, Arnold, Alice M., Atwood, Larry D., Boerwinkle, Eric, Chanock, Stephen J., Deloukas, Panos, Gieger, Christian, Gronberg, Henrik, Hall, Per, Hattersley, Andrew T., Hengstenberg, Christian, Hoffman, Wolfgang, Lathrop, G. Mark, Salomaa, Veikko, Schreiber, Stefan, Uda, Manuela, Waterworth, Dawn, Wright, Alan F., Assimes, Themistocles L., Barroso, Ines, Hofman, Albert, Mohlke, Karen L., Boomsma, Dorret I., Caulfield, Mark J., Cupples, L. Adrienne, Erdmann, Jeanette, Fox, Caroline S., Gudnason, Vilmundur, Gyllensten, Ulf, Harris, Tamara B., Hayes, Richard B., Jarvelin, Marjo-Ritta, Mooser, Vincent, Munroe, Patricia B., Ouwehand, Willem H., Penninx, Brenda W., Pramstaller, Peter P., Quertermous, Thomas, Rudan, Igor, Samani, Nilesh J., Spector, Timothy D., Voelzke, Henry, Watkins, Hugh, Wilson, James F., Groop, Leif C., Haritunians, Talin, Hu, Frank B., Kaplan, Robert C., Metspalu, Andres, North, Kari E., Schlessinger, David, Wareham, Nicholas J., Hunter, David J., O'Connell, Jeffrey R., Strachan, David P., Schadt, H. -Erich, Thorsteinsdottir, Unnur, Peltonen, Leena, Uitterlinden, Andre G., Visscher, Peter M., Chatterjee, Nilanjan, Loos, Ruth J. F., Boehnke, Michael, McCarthy, Mark I., Ingelsson, Erik, Lindgren, Cecilia M., Abecasis, Goncalo R., Stefansson, Kari, Frayling, Timothy M., and Hirschhorn, Joel N.
Abstract: Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1), but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait(2,3). The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studie, Group Author(s): Procardis Consortium
Published: 2010
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47. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Author: Heid, Iris M, Jackson, Anne U, Randall, Joshua C, Winkler, Thomas W, Qi, Lu, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Zillikens, M Carola, Speliotes, Elizabeth K, Mägi, Reedik, Workalemahu, Tsegaselassie, White, Charles C, Bouatia-Naji, Nabila, Harris, Tamara B, Berndt, Sonja I, Ingelsson, Erik, Willer, Cristen J, Weedon, Michael N, Luan, Jian'an, Vedantam, Sailaja, Esko, Tõnu, Kilpeläinen, Tuomas O, Kutalik, Zoltán, Li, Shengxu, Monda, Keri L, Dixon, Anna L, Holmes, Christopher C, Kaplan, Lee M, Liang, Liming, Min, Josine L, Moffatt, Miriam F, Molony, Cliona, Nicholson, George, Schadt, Eric E, Zondervan, Krina T, Feitosa, Mary F, Ferreira, Teresa, Allen, Hana Lango, Weyant, Robert J, Wheeler, Eleanor, Wood, Andrew R, Estrada, Karol, Goddard, Michael E, Lettre, Guillaume, Mangino, Massimo, Nyholt, Dale R, Purcell, Shaun, Smith, Albert Vernon, Visscher, Peter M, Yang, Jian, McCarroll, Steven A, Nemesh, James, Voight, Benjamin F, Absher, Devin, Amin, Najaf, Aspelund, Thor, Coin, Lachlan, Glazer, Nicole L, Hayward, Caroline, Heard-Costa, Nancy L, Hottenga, Jouke-Jan, Johansson, Åsa, Johnson, Toby, Kaakinen, Marika, Kapur, Karen, Ketkar, Shamika, Knowles, Joshua W, Kraft, Peter, Kraja, Aldi T, Lamina, Claudia, Leitzmann, Michael F, McKnight, Barbara, Morris, Andrew P, Ong, Ken K, Perry, John R B, Peters, Marjolein J, Polasek, Ozren, Prokopenko, Inga, Rayner, Nigel W, Ripatti, Samuli, Rivadeneira, Fernando, Robertson, Neil R, Sanna, Serena, Sovio, Ulla, Surakka, Ida, Teumer, Alexander, van Wingerden, Sophie, Vitart, Veronique, Zhao, Jing Hua, Cavalcanti-Proença, Christine, Chines, Peter S, Fisher, Eva, Kulzer, Jennifer R, Lecoeur, Cecile, Narisu, Narisu, Sandholt, Camilla, Scott, Laura J, Silander, Kaisa, Stark, Klaus, Tammesoo, Mari-Liis, Teslovich, Tanya M, Timpson, Nicholas John, Watanabe, Richard M, Welch, Ryan, Chasman, Daniel I, Cooper, Matthew N, Jansson, John-Olov, Kettunen, Johannes, Lawrence, Robert W, Pellikka, Niina, Perola, Markus, Vandenput, Liesbeth, Alavere, Helene, Almgren, Peter, Atwood, Larry D, Bennett, Amanda J, Biffar, Reiner, Bonnycastle, Lori L, Bornstein, Stefan R, Buchanan, Thomas A, Campbell, Harry, Day, Ian N M, Dei, Mariano, Dörr, Marcus, Elliott, Paul, Erdos, Michael R, Eriksson, Johan G, Freimer, Nelson B, Fu, Mao, Gaget, Stefan, Geus, Eco J C, Gjesing, Anette P, Grallert, Harald, Grässler, Jürgen, Groves, Christopher J, Guiducci, Candace, Hartikainen, Anna-Liisa, Hassanali, Neelam, Havulinna, Aki S, Herzig, Karl-Heinz, Hicks, Andrew A, Hui, Jennie, Igl, Wilmar, Jousilahti, Pekka, Jula, Antti, Kajantie, Eero, Kinnunen, Leena, Kolcic, Ivana, Koskinen, Seppo, Kovacs, Peter, Kroemer, Heyo K, Krzelj, Vjekoslav, Kuusisto, Johanna, Kvaloy, Kirsti, Laitinen, Jaana, Lantieri, Olivier, Lathrop, G Mark, Lokki, Marja-Liisa, Luben, Robert N, Ludwig, Barbara, McArdle, Wendy L, McCarthy, Anne, Morken, Mario A, Nelis, Mari, Neville, Matt J, Paré, Guillaume, Parker, Alex N, Peden, John F, Pichler, Irene, Pietiläinen, Kirsi H, Platou, Carl G P, Pouta, Anneli, Ridderstråle, Martin, Samani, Nilesh J, Saramies, Jouko, Sinisalo, Juha, Smit, Jan H, Strawbridge, Rona J, Stringham, Heather M, Swift, Amy J, Teder-Laving, Maris, Thomson, Brian, Usala, Gianluca, van Meurs, Joyce B J, van Ommen, Gert-Jan, Vatin, Vincent, Volpato, Claudia B, Wallaschofski, Henri, Walters, G Bragi, Widen, Elisabeth, Wild, Sarah H, Willemsen, Gonneke, Witte, Daniel R, Zgaga, Lina, Zitting, Paavo, Beilby, John P, James, Alan L, Kähönen, Mika, Lehtimäki, Terho, Nieminen, Markku S, Ohlsson, Claes, Palmer, Lyle J, Raitakari, Olli, Ridker, Paul M, Stumvoll, Michael, Tönjes, Anke, Viikari, Jorma, Balkau, Beverley, Ben-Shlomo, Yoav, Bergman, Richard N, Boeing, Heiner, Smith, George Davey, Ebrahim, Shah, Froguel, Philippe, Hansen, Torben, Hengstenberg, Christian, Hveem, Kristian, Isomaa, Bo, Jørgensen, Torben, Karpe, Fredrik, Khaw, Kay-Tee, Laakso, Markku, Lawlor, Debbie A, Marre, Michel, Meitinger, Thomas, Metspalu, Andres, Midthjell, Kristian, Pedersen, Oluf, Salomaa, Veikko, Schwarz, Peter E H, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Valle, Timo T, Wareham, Nicholas J, Arnold, Alice M, Beckmann, Jacques S, Bergmann, Sven, Boerwinkle, Eric, Boomsma, Dorret I, Caulfield, Mark J, Collins, Francis S, Eiriksdottir, Gudny, Gudnason, Vilmundur, Gyllensten, Ulf, Hamsten, Anders, Hattersley, Andrew T, Hofman, Albert, Hu, Frank B, Illig, Thomas, Iribarren, Carlos, Jarvelin, Marjo-Riitta, Kao, W H Linda, Kaprio, Jaakko, Launer, Lenore J, Munroe, Patricia B, Oostra, Ben, Penninx, Brenda W, Pramstaller, Peter P, Psaty, Bruce M, Quertermous, Thomas, Rissanen, Aila, Rudan, Igor, Shuldiner, Alan R, Soranzo, Nicole, Spector, Timothy D, Syvänen, Ann-Christine, Uda, Manuela, Uitterlinden, André, Völzke, Henry, Vollenweider, Peter, Wilson, James F, Witteman, Jacqueline C, Wright, Alan F, Abecasis, Gonçalo R, Boehnke, Michael, Borecki, Ingrid B, Deloukas, Panos, Frayling, Timothy M, Groop, Leif C, Haritunians, Talin, Hunter, David J, Kaplan, Robert C, North, Kari E, O'Connell, Jeffrey R, Peltonen, Leena, Schlessinger, David, Strachan, David P, Hirschhorn, Joel N, Assimes, Themistocles L, Wichmann, H-Erich, Thorsteinsdottir, Unnur, van Duijn, Cornelia M, Stefansson, Kari, Cupples, L Adrienne, Loos, Ruth J F, Barroso, Inês, McCarthy, Mark I, Fox, Caroline S, Mohlke, Karen L, Lindgren, Cecilia M, Heid, Iris M, Jackson, Anne U, Randall, Joshua C, Winkler, Thomas W, Qi, Lu, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Zillikens, M Carola, Speliotes, Elizabeth K, Mägi, Reedik, Workalemahu, Tsegaselassie, White, Charles C, Bouatia-Naji, Nabila, Harris, Tamara B, Berndt, Sonja I, Ingelsson, Erik, Willer, Cristen J, Weedon, Michael N, Luan, Jian'an, Vedantam, Sailaja, Esko, Tõnu, Kilpeläinen, Tuomas O, Kutalik, Zoltán, Li, Shengxu, Monda, Keri L, Dixon, Anna L, Holmes, Christopher C, Kaplan, Lee M, Liang, Liming, Min, Josine L, Moffatt, Miriam F, Molony, Cliona, Nicholson, George, Schadt, Eric E, Zondervan, Krina T, Feitosa, Mary F, Ferreira, Teresa, Allen, Hana Lango, Weyant, Robert J, Wheeler, Eleanor, Wood, Andrew R, Estrada, Karol, Goddard, Michael E, Lettre, Guillaume, Mangino, Massimo, Nyholt, Dale R, Purcell, Shaun, Smith, Albert Vernon, Visscher, Peter M, Yang, Jian, McCarroll, Steven A, Nemesh, James, Voight, Benjamin F, Absher, Devin, Amin, Najaf, Aspelund, Thor, Coin, Lachlan, Glazer, Nicole L, Hayward, Caroline, Heard-Costa, Nancy L, Hottenga, Jouke-Jan, Johansson, Åsa, Johnson, Toby, Kaakinen, Marika, Kapur, Karen, Ketkar, Shamika, Knowles, Joshua W, Kraft, Peter, Kraja, Aldi T, Lamina, Claudia, Leitzmann, Michael F, McKnight, Barbara, Morris, Andrew P, Ong, Ken K, Perry, John R B, Peters, Marjolein J, Polasek, Ozren, Prokopenko, Inga, Rayner, Nigel W, Ripatti, Samuli, Rivadeneira, Fernando, Robertson, Neil R, Sanna, Serena, Sovio, Ulla, Surakka, Ida, Teumer, Alexander, van Wingerden, Sophie, Vitart, Veronique, Zhao, Jing Hua, Cavalcanti-Proença, Christine, Chines, Peter S, Fisher, Eva, Kulzer, Jennifer R, Lecoeur, Cecile, Narisu, Narisu, Sandholt, Camilla, Scott, Laura J, Silander, Kaisa, Stark, Klaus, Tammesoo, Mari-Liis, Teslovich, Tanya M, Timpson, Nicholas John, Watanabe, Richard M, Welch, Ryan, Chasman, Daniel I, Cooper, Matthew N, Jansson, John-Olov, Kettunen, Johannes, Lawrence, Robert W, Pellikka, Niina, Perola, Markus, Vandenput, Liesbeth, Alavere, Helene, Almgren, Peter, Atwood, Larry D, Bennett, Amanda J, Biffar, Reiner, Bonnycastle, Lori L, Bornstein, Stefan R, Buchanan, Thomas A, Campbell, Harry, Day, Ian N M, Dei, Mariano, Dörr, Marcus, Elliott, Paul, Erdos, Michael R, Eriksson, Johan G, Freimer, Nelson B, Fu, Mao, Gaget, Stefan, Geus, Eco J C, Gjesing, Anette P, Grallert, Harald, Grässler, Jürgen, Groves, Christopher J, Guiducci, Candace, Hartikainen, Anna-Liisa, Hassanali, Neelam, Havulinna, Aki S, Herzig, Karl-Heinz, Hicks, Andrew A, Hui, Jennie, Igl, Wilmar, Jousilahti, Pekka, Jula, Antti, Kajantie, Eero, Kinnunen, Leena, Kolcic, Ivana, Koskinen, Seppo, Kovacs, Peter, Kroemer, Heyo K, Krzelj, Vjekoslav, Kuusisto, Johanna, Kvaloy, Kirsti, Laitinen, Jaana, Lantieri, Olivier, Lathrop, G Mark, Lokki, Marja-Liisa, Luben, Robert N, Ludwig, Barbara, McArdle, Wendy L, McCarthy, Anne, Morken, Mario A, Nelis, Mari, Neville, Matt J, Paré, Guillaume, Parker, Alex N, Peden, John F, Pichler, Irene, Pietiläinen, Kirsi H, Platou, Carl G P, Pouta, Anneli, Ridderstråle, Martin, Samani, Nilesh J, Saramies, Jouko, Sinisalo, Juha, Smit, Jan H, Strawbridge, Rona J, Stringham, Heather M, Swift, Amy J, Teder-Laving, Maris, Thomson, Brian, Usala, Gianluca, van Meurs, Joyce B J, van Ommen, Gert-Jan, Vatin, Vincent, Volpato, Claudia B, Wallaschofski, Henri, Walters, G Bragi, Widen, Elisabeth, Wild, Sarah H, Willemsen, Gonneke, Witte, Daniel R, Zgaga, Lina, Zitting, Paavo, Beilby, John P, James, Alan L, Kähönen, Mika, Lehtimäki, Terho, Nieminen, Markku S, Ohlsson, Claes, Palmer, Lyle J, Raitakari, Olli, Ridker, Paul M, Stumvoll, Michael, Tönjes, Anke, Viikari, Jorma, Balkau, Beverley, Ben-Shlomo, Yoav, Bergman, Richard N, Boeing, Heiner, Smith, George Davey, Ebrahim, Shah, Froguel, Philippe, Hansen, Torben, Hengstenberg, Christian, Hveem, Kristian, Isomaa, Bo, Jørgensen, Torben, Karpe, Fredrik, Khaw, Kay-Tee, Laakso, Markku, Lawlor, Debbie A, Marre, Michel, Meitinger, Thomas, Metspalu, Andres, Midthjell, Kristian, Pedersen, Oluf, Salomaa, Veikko, Schwarz, Peter E H, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Valle, Timo T, Wareham, Nicholas J, Arnold, Alice M, Beckmann, Jacques S, Bergmann, Sven, Boerwinkle, Eric, Boomsma, Dorret I, Caulfield, Mark J, Collins, Francis S, Eiriksdottir, Gudny, Gudnason, Vilmundur, Gyllensten, Ulf, Hamsten, Anders, Hattersley, Andrew T, Hofman, Albert, Hu, Frank B, Illig, Thomas, Iribarren, Carlos, Jarvelin, Marjo-Riitta, Kao, W H Linda, Kaprio, Jaakko, Launer, Lenore J, Munroe, Patricia B, Oostra, Ben, Penninx, Brenda W, Pramstaller, Peter P, Psaty, Bruce M, Quertermous, Thomas, Rissanen, Aila, Rudan, Igor, Shuldiner, Alan R, Soranzo, Nicole, Spector, Timothy D, Syvänen, Ann-Christine, Uda, Manuela, Uitterlinden, André, Völzke, Henry, Vollenweider, Peter, Wilson, James F, Witteman, Jacqueline C, Wright, Alan F, Abecasis, Gonçalo R, Boehnke, Michael, Borecki, Ingrid B, Deloukas, Panos, Frayling, Timothy M, Groop, Leif C, Haritunians, Talin, Hunter, David J, Kaplan, Robert C, North, Kari E, O'Connell, Jeffrey R, Peltonen, Leena, Schlessinger, David, Strachan, David P, Hirschhorn, Joel N, Assimes, Themistocles L, Wichmann, H-Erich, Thorsteinsdottir, Unnur, van Duijn, Cornelia M, Stefansson, Kari, Cupples, L Adrienne, Loos, Ruth J F, Barroso, Inês, McCarthy, Mark I, Fox, Caroline S, Mohlke, Karen L, and Lindgren, Cecilia M
Abstract: Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions., Group Author(s): MAGIC
Published: 2010
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48. Systematic identification of trans eQTLs as putative drivers of known disease associations

Author: Westra, Harm-Jan, primary, Peters, Marjolein J, additional, Esko, Tõnu, additional, Yaghootkar, Hanieh, additional, Schurmann, Claudia, additional, Kettunen, Johannes, additional, Christiansen, Mark W, additional, Fairfax, Benjamin P, additional, Schramm, Katharina, additional, Powell, Joseph E, additional, Zhernakova, Alexandra, additional, Zhernakova, Daria V, additional, Veldink, Jan H, additional, Van den Berg, Leonard H, additional, Karjalainen, Juha, additional, Withoff, Sebo, additional, Uitterlinden, André G, additional, Hofman, Albert, additional, Rivadeneira, Fernando, additional, 't Hoen, Peter A C, additional, Reinmaa, Eva, additional, Fischer, Krista, additional, Nelis, Mari, additional, Milani, Lili, additional, Melzer, David, additional, Ferrucci, Luigi, additional, Singleton, Andrew B, additional, Hernandez, Dena G, additional, Nalls, Michael A, additional, Homuth, Georg, additional, Nauck, Matthias, additional, Radke, Dörte, additional, Völker, Uwe, additional, Perola, Markus, additional, Salomaa, Veikko, additional, Brody, Jennifer, additional, Suchy-Dicey, Astrid, additional, Gharib, Sina A, additional, Enquobahrie, Daniel A, additional, Lumley, Thomas, additional, Montgomery, Grant W, additional, Makino, Seiko, additional, Prokisch, Holger, additional, Herder, Christian, additional, Roden, Michael, additional, Grallert, Harald, additional, Meitinger, Thomas, additional, Strauch, Konstantin, additional, Li, Yang, additional, Jansen, Ritsert C, additional, Visscher, Peter M, additional, Knight, Julian C, additional, Psaty, Bruce M, additional, Ripatti, Samuli, additional, Teumer, Alexander, additional, Frayling, Timothy M, additional, Metspalu, Andres, additional, van Meurs, Joyce B J, additional, and Franke, Lude, additional
Published: 2013
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49. Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics

Author: Hu, Yi-Juan, primary, Berndt, Sonja I., additional, Gustafsson, Stefan, additional, Ganna, Andrea, additional, Hirschhorn, Joel, additional, North, Kari E., additional, Ingelsson, Erik, additional, Lin, Dan-Yu, additional, Mägi, Reedik, additional, Wheeler, Eleanor, additional, Feitosa, Mary F., additional, Justice, Anne E., additional, Monda, Keri L., additional, Croteau-Chonka, Damien C., additional, Day, Felix R., additional, Esko, Tõnu, additional, Fall, Tove, additional, Ferreira, Teresa, additional, Gentilini, Davide, additional, Jackson, Anne U., additional, Luan, Jian’an, additional, Randall, Joshua C., additional, Vedantam, Sailaja, additional, Willer, Cristen J., additional, Winkler, Thomas W., additional, Wood, Andrew R., additional, Workalemahu, Tsegaselassie, additional, Hu, Yi-Juan, additional, Lee, Sang Hong, additional, Liang, Liming, additional, Min, Josine L., additional, Neale, Benjamin M., additional, Thorleifsson, Gudmar, additional, Yang, Jian, additional, Albrecht, Eva, additional, Amin, Najaf, additional, Bragg-Gresham, Jennifer L., additional, Cadby, Gemma, additional, den Heijer, Martin, additional, Eklund, Niina, additional, Fischer, Krista, additional, Goel, Anuj, additional, Hottenga, Jouke-Jan, additional, Huffman, Jennifer E., additional, Jarick, Ivonne, additional, Johansson, Åsa, additional, Johnson, Toby, additional, Kanoni, Stavroula, additional, Kleber, Marcus E., additional, König, Inke R., additional, Kristiansson, Kati, additional, Kutalik, Zoltán, additional, Lamina, Claudia, additional, Lecoeur, Cecile, additional, Li, Guo, additional, Mangino, Massimo, additional, McArdle, Wendy L., additional, Medina-Gomez, Carolina, additional, Müller-Nurasyid, Martina, additional, Ngwa, Julius S., additional, Nolte, Ilja M., additional, Paternoster, Lavinia, additional, Pechlivanis, Sonali, additional, Perola, Markus, additional, Peters, Marjolein J., additional, Preuss, Michael, additional, Rose, Lynda M., additional, Shi, Jianxin, additional, Shungin, Dmitry, additional, Smith, Albert Vernon, additional, Strawbridge, Rona J., additional, Surakka, Ida, additional, Teumer, Alexander, additional, Trip, Mieke D., additional, Tyrer, Jonathan, additional, Van Vliet-Ostaptchouk, Jana V., additional, Vandenput, Liesbeth, additional, Waite, Lindsay L., additional, Zhao, Jing Hua, additional, Absher, Devin, additional, Asselbergs, Folkert W., additional, Atalay, Mustafa, additional, Attwood, Antony P., additional, Balmforth, Anthony J., additional, Basart, Hanneke, additional, Beilby, John, additional, Bonnycastle, Lori L., additional, Brambilla, Paolo, additional, Bruinenberg, Marcel, additional, Campbell, Harry, additional, Chasman, Daniel I., additional, Chines, Peter S., additional, Collins, Francis S., additional, Connell, John M., additional, Cookson, William, additional, de Faire, Ulf, additional, de Vegt, Femmie, additional, Dei, Mariano, additional, Dimitriou, Maria, additional, Edkins, Sarah, additional, Estrada, Karol, additional, Evans, David M., additional, Farrall, Martin, additional, Ferrario, Marco M., additional, Ferrières, Jean, additional, Franke, Lude, additional, Frau, Francesca, additional, Gejman, Pablo V., additional, Grallert, Harald, additional, Grönberg, Henrik, additional, Gudnason, Vilmundur, additional, Hall, Alistair S., additional, Hall, Per, additional, Hartikainen, Anna-Liisa, additional, Hayward, Caroline, additional, Heard-Costa, Nancy L., additional, Heath, Andrew C., additional, Hebebrand, Johannes, additional, Homuth, Georg, additional, Hu, Frank B., additional, Hunt, Sarah E., additional, Hyppönen, Elina, additional, Iribarren, Carlos, additional, Jacobs, Kevin B., additional, Jansson, John-Olov, additional, Jula, Antti, additional, Kähönen, Mika, additional, Kathiresan, Sekar, additional, Kee, Frank, additional, Khaw, Kay-Tee, additional, Kivimaki, Mika, additional, Koenig, Wolfgang, additional, Kraja, Aldi T., additional, Kumari, Meena, additional, Kuulasmaa, Kari, additional, Kuusisto, Johanna, additional, Laitinen, Jaana H., additional, Lakka, Timo A., additional, Langenberg, Claudia, additional, Launer, Lenore J., additional, Lind, Lars, additional, Lindström, Jaana, additional, Liu, Jianjun, additional, Liuzzi, Antonio, additional, Lokki, Marja-Liisa, additional, Lorentzon, Mattias, additional, Madden, Pamela A., additional, Magnusson, Patrik K., additional, Manunta, Paolo, additional, Marek, Diana, additional, März, Winfried, additional, Leach, Irene Mateo, additional, McKnight, Barbara, additional, Medland, Sarah E., additional, Mihailov, Evelin, additional, Milani, Lili, additional, Montgomery, Grant W., additional, Mooser, Vincent, additional, Mühleisen, Thomas W., additional, Munroe, Patricia B., additional, Musk, Arthur W., additional, Narisu, Narisu, additional, Navis, Gerjan, additional, Nicholson, George, additional, Nohr, Ellen A., additional, Ong, Ken K., additional, Oostra, Ben A., additional, Palmer, Colin N.A., additional, Palotie, Aarno, additional, Peden, John F., additional, Pedersen, Nancy, additional, Peters, Annette, additional, Polasek, Ozren, additional, Pouta, Anneli, additional, Pramstaller, Peter P., additional, Prokopenko, Inga, additional, Pütter, Carolin, additional, Radhakrishnan, Aparna, additional, Raitakari, Olli, additional, Rendon, Augusto, additional, Rivadeneira, Fernando, additional, Rudan, Igor, additional, Saaristo, Timo E., additional, Sambrook, Jennifer G., additional, Sanders, Alan R., additional, Sanna, Serena, additional, Saramies, Jouko, additional, Schipf, Sabine, additional, Schreiber, Stefan, additional, Schunkert, Heribert, additional, Shin, So-Youn, additional, Signorini, Stefano, additional, Sinisalo, Juha, additional, Skrobek, Boris, additional, Soranzo, Nicole, additional, Stančáková, Alena, additional, Stark, Klaus, additional, Stephens, Jonathan C., additional, Stirrups, Kathleen, additional, Stolk, Ronald P., additional, Stumvoll, Michael, additional, Swift, Amy J., additional, Theodoraki, Eirini V., additional, Thorand, Barbara, additional, Tregouet, David-Alexandre, additional, Tremoli, Elena, additional, Van der Klauw, Melanie M., additional, van Meurs, Joyce B.J., additional, Vermeulen, Sita H., additional, Viikari, Jorma, additional, Virtamo, Jarmo, additional, Vitart, Veronique, additional, Waeber, Gérard, additional, Wang, Zhaoming, additional, Widén, Elisabeth, additional, Wild, Sarah H., additional, Willemsen, Gonneke, additional, Winkelmann, Bernhard R., additional, Witteman, Jacqueline C.M., additional, Wolffenbuttel, Bruce H.R., additional, Wong, Andrew, additional, Wright, Alan F., additional, Zillikens, M. Carola, additional, Amouyel, Philippe, additional, Boehm, Bernhard O., additional, Boerwinkle, Eric, additional, Boomsma, Dorret I., additional, Caulfield, Mark J., additional, Chanock, Stephen J., additional, Cupples, L. Adrienne, additional, Cusi, Daniele, additional, Dedoussis, George V., additional, Erdmann, Jeanette, additional, Eriksson, Johan G., additional, Franks, Paul W., additional, Froguel, Philippe, additional, Gieger, Christian, additional, Gyllensten, Ulf, additional, Hamsten, Anders, additional, Harris, Tamara B., additional, Hengstenberg, Christian, additional, Hicks, Andrew A., additional, Hingorani, Aroon, additional, Hinney, Anke, additional, Hofman, Albert, additional, Hovingh, Kees G., additional, Hveem, Kristian, additional, Illig, Thomas, additional, Jarvelin, Marjo-Riitta, additional, Jöckel, Karl-Heinz, additional, Keinanen-Kiukaanniemi, Sirkka M., additional, Kiemeney, Lambertus A., additional, Kuh, Diana, additional, Laakso, Markku, additional, Lehtimäki, Terho, additional, Levinson, Douglas F., additional, Martin, Nicholas G., additional, Metspalu, Andres, additional, Morris, Andrew D., additional, Nieminen, Markku S., additional, Njølstad, Inger, additional, Ohlsson, Claes, additional, Oldehinkel, Albertine J., additional, Ouwehand, Willem H., additional, Palmer, Lyle J., additional, Penninx, Brenda, additional, Power, Chris, additional, Province, Michael A., additional, Psaty, Bruce M., additional, Qi, Lu, additional, Rauramaa, Rainer, additional, Ridker, Paul M., additional, Ripatti, Samuli, additional, Salomaa, Veikko, additional, Samani, Nilesh J., additional, Snieder, Harold, additional, Sørensen, Thorkild I.A., additional, Spector, Timothy D., additional, Stefansson, Kari, additional, Tönjes, Anke, additional, Tuomilehto, Jaakko, additional, Uitterlinden, André G., additional, Uusitupa, Matti, additional, van der Harst, Pim, additional, Vollenweider, Peter, additional, Wallaschofski, Henri, additional, Wareham, Nicholas J., additional, Watkins, Hugh, additional, Wichmann, H.-Erich, additional, Wilson, James F., additional, Abecasis, Goncalo R., additional, Assimes, Themistocles L., additional, Barroso, Inês, additional, Boehnke, Michael, additional, Borecki, Ingrid B., additional, Deloukas, Panos, additional, Fox, Caroline S., additional, Frayling, Timothy, additional, Groop, Leif C., additional, Haritunian, Talin, additional, Heid, Iris M., additional, Hunter, David, additional, Kaplan, Robert C., additional, Karpe, Fredrik, additional, Moffatt, Miriam, additional, Mohlke, Karen L., additional, O’Connell, Jeffrey R., additional, Pawitan, Yudi, additional, Schadt, Eric E., additional, Schlessinger, David, additional, Steinthorsdottir, Valgerdur, additional, Strachan, David P., additional, Thorsteinsdottir, Unnur, additional, van Duijn, Cornelia M., additional, Visscher, Peter M., additional, Di Blasio, Anna Maria, additional, Hirschhorn, Joel N., additional, Lindgren, Cecilia M., additional, Morris, Andrew P., additional, Meyre, David, additional, Scherag, André, additional, McCarthy, Mark I., additional, Speliotes, Elizabeth K., additional, North, Kari E., additional, and Loos, Ruth J.F., additional
Published: 2013
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50. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Author: Berndt, Sonja I, primary, Gustafsson, Stefan, additional, Mägi, Reedik, additional, Ganna, Andrea, additional, Wheeler, Eleanor, additional, Feitosa, Mary F, additional, Justice, Anne E, additional, Monda, Keri L, additional, Croteau-Chonka, Damien C, additional, Day, Felix R, additional, Esko, Tõnu, additional, Fall, Tove, additional, Ferreira, Teresa, additional, Gentilini, Davide, additional, Jackson, Anne U, additional, Luan, Jian'an, additional, Randall, Joshua C, additional, Vedantam, Sailaja, additional, Willer, Cristen J, additional, Winkler, Thomas W, additional, Wood, Andrew R, additional, Workalemahu, Tsegaselassie, additional, Hu, Yi-Juan, additional, Lee, Sang Hong, additional, Liang, Liming, additional, Lin, Dan-Yu, additional, Min, Josine L, additional, Neale, Benjamin M, additional, Thorleifsson, Gudmar, additional, Yang, Jian, additional, Albrecht, Eva, additional, Amin, Najaf, additional, Bragg-Gresham, Jennifer L, additional, Cadby, Gemma, additional, den Heijer, Martin, additional, Eklund, Niina, additional, Fischer, Krista, additional, Goel, Anuj, additional, Hottenga, Jouke-Jan, additional, Huffman, Jennifer E, additional, Jarick, Ivonne, additional, Johansson, Åsa, additional, Johnson, Toby, additional, Kanoni, Stavroula, additional, Kleber, Marcus E, additional, König, Inke R, additional, Kristiansson, Kati, additional, Kutalik, Zoltán, additional, Lamina, Claudia, additional, Lecoeur, Cecile, additional, Li, Guo, additional, Mangino, Massimo, additional, McArdle, Wendy L, additional, Medina-Gomez, Carolina, additional, Müller-Nurasyid, Martina, additional, Ngwa, Julius S, additional, Nolte, Ilja M, additional, Paternoster, Lavinia, additional, Pechlivanis, Sonali, additional, Perola, Markus, additional, Peters, Marjolein J, additional, Preuss, Michael, additional, Rose, Lynda M, additional, Shi, Jianxin, additional, Shungin, Dmitry, additional, Smith, Albert Vernon, additional, Strawbridge, Rona J, additional, Surakka, Ida, additional, Teumer, Alexander, additional, Trip, Mieke D, additional, Tyrer, Jonathan, additional, Van Vliet-Ostaptchouk, Jana V, additional, Vandenput, Liesbeth, additional, Waite, Lindsay L, additional, Zhao, Jing Hua, additional, Absher, Devin, additional, Asselbergs, Folkert W, additional, Atalay, Mustafa, additional, Attwood, Antony P, additional, Balmforth, Anthony J, additional, Basart, Hanneke, additional, Beilby, John, additional, Bonnycastle, Lori L, additional, Brambilla, Paolo, additional, Bruinenberg, Marcel, additional, Campbell, Harry, additional, Chasman, Daniel I, additional, Chines, Peter S, additional, Collins, Francis S, additional, Connell, John M, additional, Cookson, William O, additional, de Faire, Ulf, additional, de Vegt, Femmie, additional, Dei, Mariano, additional, Dimitriou, Maria, additional, Edkins, Sarah, additional, Estrada, Karol, additional, Evans, David M, additional, Farrall, Martin, additional, Ferrario, Marco M, additional, Ferrières, Jean, additional, Franke, Lude, additional, Frau, Francesca, additional, Gejman, Pablo V, additional, Grallert, Harald, additional, Grönberg, Henrik, additional, Gudnason, Vilmundur, additional, Hall, Alistair S, additional, Hall, Per, additional, Hartikainen, Anna-Liisa, additional, Hayward, Caroline, additional, Heard-Costa, Nancy L, additional, Heath, Andrew C, additional, Hebebrand, Johannes, additional, Homuth, Georg, additional, Hu, Frank B, additional, Hunt, Sarah E, additional, Hyppönen, Elina, additional, Iribarren, Carlos, additional, Jacobs, Kevin B, additional, Jansson, John-Olov, additional, Jula, Antti, additional, Kähönen, Mika, additional, Kathiresan, Sekar, additional, Kee, Frank, additional, Khaw, Kay-Tee, additional, Kivimäki, Mika, additional, Koenig, Wolfgang, additional, Kraja, Aldi T, additional, Kumari, Meena, additional, Kuulasmaa, Kari, additional, Kuusisto, Johanna, additional, Laitinen, Jaana H, additional, Lakka, Timo A, additional, Langenberg, Claudia, additional, Launer, Lenore J, additional, Lind, Lars, additional, Lindström, Jaana, additional, Liu, Jianjun, additional, Liuzzi, Antonio, additional, Lokki, Marja-Liisa, additional, Lorentzon, Mattias, additional, Madden, Pamela A, additional, Magnusson, Patrik K, additional, Manunta, Paolo, additional, Marek, Diana, additional, März, Winfried, additional, Leach, Irene Mateo, additional, McKnight, Barbara, additional, Medland, Sarah E, additional, Mihailov, Evelin, additional, Milani, Lili, additional, Montgomery, Grant W, additional, Mooser, Vincent, additional, Mühleisen, Thomas W, additional, Munroe, Patricia B, additional, Musk, Arthur W, additional, Narisu, Narisu, additional, Navis, Gerjan, additional, Nicholson, George, additional, Nohr, Ellen A, additional, Ong, Ken K, additional, Oostra, Ben A, additional, Palmer, Colin N A, additional, Palotie, Aarno, additional, Peden, John F, additional, Pedersen, Nancy, additional, Peters, Annette, additional, Polasek, Ozren, additional, Pouta, Anneli, additional, Pramstaller, Peter P, additional, Prokopenko, Inga, additional, Pütter, Carolin, additional, Radhakrishnan, Aparna, additional, Raitakari, Olli, additional, Rendon, Augusto, additional, Rivadeneira, Fernando, additional, Rudan, Igor, additional, Saaristo, Timo E, additional, Sambrook, Jennifer G, additional, Sanders, Alan R, additional, Sanna, Serena, additional, Saramies, Jouko, additional, Schipf, Sabine, additional, Schreiber, Stefan, additional, Schunkert, Heribert, additional, Shin, So-Youn, additional, Signorini, Stefano, additional, Sinisalo, Juha, additional, Skrobek, Boris, additional, Soranzo, Nicole, additional, Stančáková, Alena, additional, Stark, Klaus, additional, Stephens, Jonathan C, additional, Stirrups, Kathleen, additional, Stolk, Ronald P, additional, Stumvoll, Michael, additional, Swift, Amy J, additional, Theodoraki, Eirini V, additional, Thorand, Barbara, additional, Tregouet, David-Alexandre, additional, Tremoli, Elena, additional, Van der Klauw, Melanie M, additional, van Meurs, Joyce B J, additional, Vermeulen, Sita H, additional, Viikari, Jorma, additional, Virtamo, Jarmo, additional, Vitart, Veronique, additional, Waeber, Gérard, additional, Wang, Zhaoming, additional, Widén, Elisabeth, additional, Wild, Sarah H, additional, Willemsen, Gonneke, additional, Winkelmann, Bernhard R, additional, Witteman, Jacqueline C M, additional, Wolffenbuttel, Bruce H R, additional, Wong, Andrew, additional, Wright, Alan F, additional, Zillikens, M Carola, additional, Amouyel, Philippe, additional, Boehm, Bernhard O, additional, Boerwinkle, Eric, additional, Boomsma, Dorret I, additional, Caulfield, Mark J, additional, Chanock, Stephen J, additional, Cupples, L Adrienne, additional, Cusi, Daniele, additional, Dedoussis, George V, additional, Erdmann, Jeanette, additional, Eriksson, Johan G, additional, Franks, Paul W, additional, Froguel, Philippe, additional, Gieger, Christian, additional, Gyllensten, Ulf, additional, Hamsten, Anders, additional, Harris, Tamara B, additional, Hengstenberg, Christian, additional, Hicks, Andrew A, additional, Hingorani, Aroon, additional, Hinney, Anke, additional, Hofman, Albert, additional, Hovingh, Kees G, additional, Hveem, Kristian, additional, Illig, Thomas, additional, Jarvelin, Marjo-Riitta, additional, Jöckel, Karl-Heinz, additional, Keinanen-Kiukaanniemi, Sirkka M, additional, Kiemeney, Lambertus A, additional, Kuh, Diana, additional, Laakso, Markku, additional, Lehtimäki, Terho, additional, Levinson, Douglas F, additional, Martin, Nicholas G, additional, Metspalu, Andres, additional, Morris, Andrew D, additional, Nieminen, Markku S, additional, Njølstad, Inger, additional, Ohlsson, Claes, additional, Oldehinkel, Albertine J, additional, Ouwehand, Willem H, additional, Palmer, Lyle J, additional, Penninx, Brenda, additional, Power, Chris, additional, Province, Michael A, additional, Psaty, Bruce M, additional, Qi, Lu, additional, Rauramaa, Rainer, additional, Ridker, Paul M, additional, Ripatti, Samuli, additional, Salomaa, Veikko, additional, Samani, Nilesh J, additional, Snieder, Harold, additional, Sørensen, Thorkild I A, additional, Spector, Timothy D, additional, Stefansson, Kari, additional, Tönjes, Anke, additional, Tuomilehto, Jaakko, additional, Uitterlinden, André G, additional, Uusitupa, Matti, additional, van der Harst, Pim, additional, Vollenweider, Peter, additional, Wallaschofski, Henri, additional, Wareham, Nicholas J, additional, Watkins, Hugh, additional, Wichmann, H-Erich, additional, Wilson, James F, additional, Abecasis, Goncalo R, additional, Assimes, Themistocles L, additional, Barroso, Inês, additional, Boehnke, Michael, additional, Borecki, Ingrid B, additional, Deloukas, Panos, additional, Fox, Caroline S, additional, Frayling, Timothy, additional, Groop, Leif C, additional, Haritunian, Talin, additional, Heid, Iris M, additional, Hunter, David, additional, Kaplan, Robert C, additional, Karpe, Fredrik, additional, Moffatt, Miriam F, additional, Mohlke, Karen L, additional, O'Connell, Jeffrey R, additional, Pawitan, Yudi, additional, Schadt, Eric E, additional, Schlessinger, David, additional, Steinthorsdottir, Valgerdur, additional, Strachan, David P, additional, Thorsteinsdottir, Unnur, additional, van Duijn, Cornelia M, additional, Visscher, Peter M, additional, Di Blasio, Anna Maria, additional, Hirschhorn, Joel N, additional, Lindgren, Cecilia M, additional, Morris, Andrew P, additional, Meyre, David, additional, Scherag, André, additional, McCarthy, Mark I, additional, Speliotes, Elizabeth K, additional, North, Kari E, additional, Loos, Ruth J F, additional, and Ingelsson, Erik, additional
Published: 2013
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