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17. Trends in cancer incidence by socioeconomic deprivation in Germany in 2007 to 2018: An ecological registry‐based study

Author

Jansen, Lina, primary, Schwettmann, Lars, additional, Behr, Christian, additional, Eberle, Andrea, additional, Holleczek, Bernd, additional, Justenhoven, Christina, additional, Kajüter, Hiltraud, additional, Manz, Kirsi, additional, Peters, Frederik, additional, Pritzkuleit, Ron, additional, Schmidt‐Pokrzywniak, Andrea, additional, Sirri, Eunice, additional, Tetzlaff, Fabian, additional, Voigtländer, Sven, additional, and Arndt, Volker, additional

Published
2023
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19. Cross-Sectional Association of Dietary Patterns and Supplement Intake with Presence and Gray-Scale Median of Carotid Plaques—A Comparison between Women and Men in the Population-Based Hamburg City Health Study

Author

Assies, Julia Maria, primary, Sältz, Martje Dorothea, additional, Peters, Frederik, additional, Behrendt, Christian-Alexander, additional, Jagodzinski, Annika, additional, Petersen, Elina Larissa, additional, Schäfer, Ines, additional, Twerenbold, Raphael, additional, Blankenberg, Stefan, additional, Rimmele, David Leander, additional, Thomalla, Götz, additional, Makarova, Nataliya, additional, and Zyriax, Birgit-Christiane, additional

Published
2023
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20. Trends in cancer incidence by socioeconomic deprivation in Germany in 2007 to 2018: an ecological registry‐based study

Author

Jansen, Lina, Schwettmann, Lars, Behr, Christian, Eberle, Andrea, Holleczek, Bernd, Justenhoven, Christina, Kajüter, Hiltraud, Manz, Kirsi, Peters, Frederik, Pritzkuleit, Ron, Schmidt‐Pokrzywniak, Andrea, Sirri, Eunice, Tetzlaff, Fabian, Voigtländer, Sven, Arndt, Volker, Jansen, Lina, Schwettmann, Lars, Behr, Christian, Eberle, Andrea, Holleczek, Bernd, Justenhoven, Christina, Kajüter, Hiltraud, Manz, Kirsi, Peters, Frederik, Pritzkuleit, Ron, Schmidt‐Pokrzywniak, Andrea, Sirri, Eunice, Tetzlaff, Fabian, Voigtländer, Sven, and Arndt, Volker

Abstract

Age-standardized cancer incidence has decreased over the last years for many cancer sites in developed countries. Whether these trends led to narrowing or widening socioeconomic inequalities in cancer incidence is unknown. Using cancer registry data covering 48 million inhabitants in Germany, the ecological association between age-standardized total and site specific (colorectal, lung, prostate and breast) cancer incidence in 2007 to 2018 and a deprivation index on district level (aggregated to quintiles) was investigated. Incidence in the most and least deprived districts were compared using Poisson models. Average annual percentage changes (AAPCs) and differences in AAPCs between deprivation quintiles were assessed using Joinpoint regression analyses. Age-standardized incidence decreased strongly between 2007 and 2018 for total cancer and all cancer sites (except female lung cancer), irrespective of the level of deprivation. However, differences in the magnitude of trends across deprivation quintiles resulted in increasing inequalities over time for total cancer, colorectal and lung cancer. For total cancer, the incidence rate ratio between the most and least deprived quintile increased from 1.07 (95% confidence interval: 1.01-1.12) to 1.23 (1.12-1.32) in men and from 1.07 (1.01-1.13) to 1.20 (1.14-1.26) in women. Largest inequalities were observed for lung cancer with 82% (men) and 88% (women) higher incidence in the most vs the least deprived regions in 2018. The observed increase in inequalities in cancer incidence is in alignment with trends in inequalities in risk factor prevalence and partly utilization of screening. Intervention programs targeted at socioeconomically deprived and urban regions are highly needed.

Published
2023

22. Epidemiologie von Kopf-Hals-Tumoren in Deutschland

Author

Jansen, Lina, primary, Moratin, Julius, additional, Behr, Christian, additional, Holleczek, Bernd, additional, Luttmann, Sabine, additional, Peters, Frederik, additional, Robers, Gabriele, additional, Schmidt-Pokrzywniak, Andrea, additional, Pritzkuleit, Ron, additional, Sirri, Eunice, additional, Stang, Andreas, additional, and Arndt, Volker, additional

Published
2022
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24. Long-term Mortality and Reintervention after Endovascular and Open Abdominal Aortic Aneurysm Repairs in Australia, Germany, and the US

Author

Mao, Jialin, primary, Behrendt, Christian-Alexander, additional, Falster, Michael O., additional, Varcoe, Ramon L., additional, Zheng, Xinyan, additional, Peters, Frederik, additional, Beiles, Barry, additional, Schermerhorn, Marc L., additional, Jorm, Louisa, additional, Beck, Adam W., additional, and Sedrakyan, Art, additional

Published
2022
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28. The Impact of Chronic Kidney Disease on Mid-Term Outcomes after Revascularisation of Peripheral Arterial Occlusive Disease: Results from a Prospective Cohort Study

Author

Kotov, Artur, primary, Blasche, Deven A., additional, Peters, Frederik, additional, Pospiech, Philip, additional, Rother, Ulrich, additional, Stavroulakis, Konstantinos, additional, Remig, Jürgen, additional, Schmidt-Lauber, Christian, additional, Zeller, Thomas, additional, Görtz, Hartmut, additional, Teßarek, Jörg, additional, and Behrendt, Christian-Alexander, additional

Published
2022
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30. Distribution of Mobile Health Applications amongst Patients with Symptomatic Peripheral Arterial Disease in Germany: A Cross-Sectional Survey Study

Author

Alushi, Kastriot, Hinterseher, Irene, Peters, Frederik, Rother, Ulrich, Bischoff, Moritz S., Mylonas, Spyridon, Grambow, Eberhard, Gombert, Alexander, Busch, Albert, Gray, Daphne, Konstantinou, Nikolaos, Stavroulakis, Konstantinos, Horn, Marco, Goertz, Hartmut, Uhl, Christian, Federrath, Hannes, Trute, Hans-Heinrich, Kreutzburg, Thea, Behrendt, Christian-Alexander, Alushi, Kastriot, Hinterseher, Irene, Peters, Frederik, Rother, Ulrich, Bischoff, Moritz S., Mylonas, Spyridon, Grambow, Eberhard, Gombert, Alexander, Busch, Albert, Gray, Daphne, Konstantinou, Nikolaos, Stavroulakis, Konstantinos, Horn, Marco, Goertz, Hartmut, Uhl, Christian, Federrath, Hannes, Trute, Hans-Heinrich, Kreutzburg, Thea, and Behrendt, Christian-Alexander

Abstract

Background: Broadly available digital and mobile health applications (also known as mHealth) have recently gained increasing attention by the vascular community, but very little is known about the dissemination and acceptance of such technologies in certain target populations. The current study aimed to determine the user behaviour and acceptance of such digital technologies amongst patients with peripheral arterial disease (PAD). Methods: A cross-sectional survey of consecutively treated inpatients at 12 university institutions, as well as one non-university institution, was conducted. All admitted patients with symptomatic PAD were surveyed for 30 consecutive days within a flexible timeframe between 1 July and 30 September 2021. The factors associated with smartphone use were estimated via backward selection within a logistic regression model with clustered standard errors. Results: A total of 326 patients participated (response rate 96.3%), thereof 102 (34.0%) were treated for intermittent claudication (IC, 29.2% women, 70 years in median) and 198 were treated for chronic limb-threatening ischaemia (CLTI, 29.5% women, 70 years in median). Amongst all of the patients, 46.6% stated that they had not changed their lifestyle and health behaviour since the index diagnosis (four years in median), and 33.1% responded that they were not aware of the reasons for all of their medication orders. Amongst all those surveyed, 66.8% owned a smartphone (IC: 70.6%, CLTI: 64.1%), thereof 27.9% needed regular user support. While 42.5% used smartphone apps, only 15.0% used mobile health applications, and 19.0% owned wearables. One out of five patients agreed that such technologies could help to improve their healthy lifestyle. Only higher age was inversely associated with smartphone possession. Conclusions: The current survey showed that smartphones are prevalent amongst patients with peripheral arterial disease, but only a small proportion used mobile health applications and a cons

Published
2022

31. Editor's Choice – Prevalence of Peripheral Arterial Disease, Abdominal Aortic Aneurysm, and Risk Factors in the Hamburg City Health Study: A Cross Sectional Analysis.

Author

Behrendt, Christian-Alexander, Thomalla, Götz, Rimmele, David L., Petersen, Elina L., Twerenbold, Raphael, Debus, Eike S., Kölbel, Tilo, Blankenberg, Stefan, Schmidt-Lauber, Christian, Peters, Frederik, and Zyriax, Birgit-Christiane

Abstract

There is a paucity of current figures on the prevalence of carotid and lower extremity peripheral arterial disease (PAD) and abdominal aortic aneurysm (AAA) as well as the associated cardiovascular risk factors to support considerations on screening programmes. In the population based Hamburg City Health Study, participants between 45 and 74 years were randomly recruited. In the current cross sectional analysis of the first 10 000 participants enrolled between February 2016 and November 2018, the prevalence of carotid artery disease (intima–media thickness ≥ 1 mm), lower extremity PAD (ankle brachial index ≤ 0.9), and AAA (aortic diameter ≥ 30 mm) was determined. Multivariable logistic regression models were applied to determine the association between vascular diseases and risk factors. To account for missing values, multiple imputation was performed. A total of 10 000 participants were analysed (51.1% females, median age 63 years, median body mass index 26.1 kg/m2). In medians, the intima media thickness was 0.74 mm (interquartile range [IQR] 0.65 – 0.84), the ankle brachial index 1.04 (IQR 0.95 – 1.13), and the aortic diameter 17.8 mm (IQR 16.1 – 19.6). Concerning risk factors, 64% self reported any smoking, 39% hypertension, 5% coronary artery disease, 3% congestive heart failure, 5% atrial fibrillation, and 3% history of stroke or myocardial infarction, respectively. In males, the prevalence of carotid artery disease, lower extremity PAD, and AAA were 35.3%, 22.7%, and 1.3%, respectively, and in females, 23.4%, 24.8%, and 0.2%, respectively. Higher age and current smoking were likewise associated with higher prevalence while the impact of variables varied widely. In this large population based cohort study of 10 000 subjects from Hamburg, Germany, a strikingly high prevalence of PAD was revealed. Almost 45% suffered from any index disease, while AAA was only diagnosed in 1.3% of males and 0.2% of females. The high prevalence of atherosclerotic disease and associated cardiovascular risk factors underline that it is essential to increase awareness and fuel efforts for secondary prevention. [ABSTRACT FROM AUTHOR]

Published
2023
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32. The Relationship Between Hospital Procedure Volume and Outcomes After Endovascular or Open Surgical Revascularisation for Peripheral Arterial Disease: An Analysis of Health Insurance Claims Data.

Author

Kuchenbecker, Jenny, Peters, Frederik, Kreutzburg, Thea, Marschall, Ursula, L'Hoest, Helmut, and Behrendt, Christian-Alexander

Abstract

There is a paucity of data on the relationship between hospital procedure volume and outcomes after inpatient treatment of symptomatic peripheral arterial disease (PAD). This study aimed to generate meaningful hypotheses to support the ongoing discussion. Data derived from BARMER, Germany's second largest insurance provider, were linked with nationwide hospital procedure volumes from mandatory hospital quality reports. All endovascular (EVR) and open surgical revascularisations (OSR) provided to patients (≥ 40 years) with symptomatic PAD between 1 January 2013 and 31 December 2018 were included. Hospital volume was defined as the number of procedures performed by a hospital in the previous calendar year (in quartiles). Freedom from re-intervention, amputation, and overall mortality rate within 12 months after discharge were analysed using multivariable Cox proportional hazards models. In hospital mortality was determined by generalised estimating equations logistic regression models. There were 88 187 revascularisations (72.4% EVR; EVR: 72.7 years and 45.2% females; OSR: 71.9 years and 41.9% females) registered by 668 hospitals. No statistically significant association was found between 12 month freedom from re-intervention and hospital volume (EVR: 4; quartile HR 1.05; 95% CI 0.94 – 1.16. OSR: 4; quartile HR 1.05; 95% CI 0.92 – 1.21). Patients with OSR had a decreased hazard of 12 month mortality in a high volume hospital compared with a low volume hospital (HR 0.85; 95% CI 0.73 – 0.98), but not with EVR (HR 1.03; 95% CI 0.91 – 1.16). Patients who were treated in hospitals with highest volumes showed decreased hazards of 12 month freedom from amputation when compared with low volume hospitals (EVR: HR 0.72; 95% CI 0.52 – 0.99. OSR: HR 0.61; 95% CI 0.44 – 0.85). This large retrospective analysis of insurance claims suggests that higher procedure volume is associated with lower major amputation rates, although there is a need for standardisation of the definition of volume stratification. Future studies should address the impact of subsequent outpatient care and surveillance to further examine the complex interaction between treatment and outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Distribution of Mobile Health Applications amongst Patients with Symptomatic Peripheral Arterial Disease in Germany: A Cross-Sectional Survey Study

Author

Alushi, Kastriot, primary, Hinterseher, Irene, additional, Peters, Frederik, additional, Rother, Ulrich, additional, Bischoff, Moritz S., additional, Mylonas, Spyridon, additional, Grambow, Eberhard, additional, Gombert, Alexander, additional, Busch, Albert, additional, Gray, Daphne, additional, Konstantinou, Nikolaos, additional, Stavroulakis, Konstantinos, additional, Horn, Marco, additional, Görtz, Hartmut, additional, Uhl, Christian, additional, Federrath, Hannes, additional, Trute, Hans-Heinrich, additional, Kreutzburg, Thea, additional, and Behrendt, Christian-Alexander, additional

Published
2022
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37. The prospective GermanVasc cohort study

Author

Kotov, Artur, primary, Peters, Frederik, additional, Debus, Eike Sebastian, additional, Zeller, Thomas, additional, Heider, Peter, additional, Stavroulakis, Konstantinos, additional, Remig, Jürgen, additional, Gussmann, Andreas, additional, Hoffmann, Johannes, additional, Friedrich, Oliver, additional, Nolte, Thomas, additional, and Behrendt, Christian-Alexander, additional

Published
2021
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38. Sex Disparities in Long-Term Mortality after Paclitaxel Exposure in Patients with Peripheral Artery Disease: A Nationwide Claims-Based Cohort Study

Author

Behrendt, Christian-Alexander, primary, Sedrakyan, Art, additional, Katsanos, Konstantinos, additional, Nordanstig, Joakim, additional, Kuchenbecker, Jenny, additional, Kreutzburg, Thea, additional, Secemsky, Eric A., additional, Debus, Eike Sebastian, additional, Marschall, Ursula, additional, and Peters, Frederik, additional

Published
2021
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40. Follow-up durch flächendeckende Krebsregister in Deutschland: wertvolle Daten auf solider Grundlage

Author

Holleczek, Bernd, Nennecke, Alice, Fell, Barbara, and Peters, Frederik

Abstract

Hintergrund: Mit dem Ausbau der flächendeckenden klinischen Krebsregister (KR) in Deutschland mit kontinuierlich dokumentierten klinischen Therapie- und Verlaufsinformationen wurde die Datenlage zur Nachverfolgung onkologischer PatientInnen umfassend erweitert. Ziel der Arbeit: Es werden neue Nutzungsmöglichkeiten des Follow-up durch KR exemplarisch dargestellt. Im Fokus stehen verschiedene Betrachtungsansätze, Implikationen für die Datennutzung und Grenzen der Aussagekraft. Material und Methoden: Verwendet wurden Daten der KR Hamburgs und des Saarlandes zu Karzinomen in Pankreas, Zervix und Prostata mit Erstdiagnose im Zeitraum 2017–2021. Untersucht wurden Überlebenswahrscheinlichkeiten mittels Life-Table-Ansatz, Kaplan-Meier-Schätzern und proportionalen Hazard-Modellen nach Cox sowie das kumulative Risiko von Tumorrezidiven. Ergebnisse: Das 3‑Jahres-Überleben von PatientInnen mit Adenokarzinomen des Pankreas lag je nach Stadium, Altersgruppe, Geschlecht, Wohnort und operativer Behandlung zwischen 9 und 60 %. Für Patientinnen mit Zervixkarzinom errechnete sich für Auswärtige ein um mehr als die Hälfte niedrigeres Sterberisiko im Vergleich zu denen mit Wohnsitz im KR-Einzugsgebiet. Nach radikaler Prostatovesikulektomie mit dokumentierter lokaler Tumorfreiheit war das Risiko eines Tumorrezidivs 2,6-fach erhöht, wenn das Karzinom nicht mehr auf die Prostata beschränkt war. Schlussfolgerung: Nach Ausbau der KR liegen für onkologische Leistungserbringer und wissenschaftliche Forschung flächendeckend wertvolle detaillierte klinische Daten zu Krebserkrankungsfällen und deren Verlauf vor. Für aussagekräftige, relevante Ergebnisse sind die konkreten Analysen dabei an klinische Subgruppen, Letalität der Erkrankung und Art des Endpunkts anzupassen, um Scheinkorrelationen zu vermeiden.

Published
2023
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46. Female Sex and Outcomes after Endovascular Aneurysm Repair for Abdominal Aortic Aneurysm: A Propensity Score Matched Cohort Analysis

Author

Behrendt, Christian-Alexander, primary, Kreutzburg, Thea, additional, Kuchenbecker, Jenny, additional, Panuccio, Giuseppe, additional, Dankhoff, Mark, additional, Spanos, Konstantinos, additional, Kouvelos, George, additional, Debus, Sebastian, additional, Peters, Frederik, additional, and Kölbel, Tilo, additional

Published
2021
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48. Long-term incidence of cancer after index treatment for symptomatic peripheral arterial disease – a health insurance claims data analysis

Author

Kaschwich, Mark, primary, Peters, Frederik, additional, Hischke, Sandra, additional, Rieß, Henrik C., additional, Gansel, Max, additional, Marschall, Ursula, additional, L’Hoest, Helmut, additional, Heidemann, Franziska, additional, Debus, E. Sebastian, additional, Acar, Laura, additional, Kreutzburg, Thea, additional, and Behrendt, Christian-Alexander, additional

Published
2020
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