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1. Ultra-rapid warming yields high survival of mouse oocytes cooled to -196°c in dilutions of a standard vitrification solution.

Author: Shinsuke Seki and Peter Mazur
Subjects: Medicine, Science
Abstract: Intracellular ice is generally lethal. One way to avoid it is to vitrify cells; that is, to convert cell water to a glass rather than to ice. The belief has been that this requires both the cooling rate and the concentration of glass-inducing solutes be very high. But high solute concentrations can themselves be damaging. However, the findings we report here on the vitrification of mouse oocytes are not in accord with the first belief that cooling needs to be extremely rapid. The important requirement is that the warming rate be extremely high. We subjected mouse oocytes in the vitrification solution EAFS 10/10 to vitrification procedures using a broad range of cooling and warming rates. Morphological survivals exceeded 80% when they were warmed at the highest rate (117,000°C/min) even when the prior cooling rate was as low as 880°C/min. Functional survival was >81% and 54% with the highest warming rate after cooling at 69,000 and 880°C/min, respectively. Our findings are also contrary to the second belief. We show that a high percentage of mouse oocytes survive vitrification in media that contain only half the usual concentration of solutes, provided they are warmed extremely rapidly; that is, >100,000°C/min. Again, the cooling rate is of less consequence.
Published: 2012
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2. Rectification of the water permeability in COS-7 cells at 22, 10 and 0°C.

Author: Diana B Peckys, F W Kleinhans, and Peter Mazur
Subjects: Medicine, Science
Abstract: The osmotic and permeability parameters of a cell membrane are essential physico-chemical properties of a cell and particularly important with respect to cell volume changes and the regulation thereof. Here, we report the hydraulic conductivity, L(p), the non-osmotic volume, V(b), and the Arrhenius activation energy, E(a), of mammalian COS-7 cells. The ratio of V(b) to the isotonic cell volume, V(c iso), was 0.29. E(a), the activation energy required for the permeation of water through the cell membrane, was 10,700, and 12,000 cal/mol under hyper- and hypotonic conditions, respectively. Average values for L(p) were calculated from swell/shrink curves by using an integrated equation for L(p). The curves represented the volume changes of 358 individually measured cells, placed into solutions of nonpermeating solutes of 157 or 602 mOsm/kg (at 0, 10 or 22°C) and imaged over time. L(p) estimates for all six combinations of osmolality and temperature were calculated, resulting in values of 0.11, 0.21, and 0.10 µm/min/atm for exosmotic flow and 0.79, 1.73 and 1.87 µm/min/atm for endosmotic flow (at 0, 10 and 22°C, respectively). The unexpected finding of several fold higher L(p) values for endosmotic flow indicates highly asymmetric membrane permeability for water in COS-7. This phenomenon is known as rectification and has mainly been reported for plant cell, but only rarely for animal cells. Although the mechanism underlying the strong rectification found in COS-7 cells is yet unknown, it is a phenomenon of biological interest and has important practical consequences, for instance, in the development of optimal cryopreservation.
Published: 2011
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3. Probing hadronic interactions using the latest data measured by the Pierre Auger Observatory

Author: Caterina Trimarelli, Pedro Abreu, Marco Aglietta, Ingomar Allekotte, Kévin Almeida Cheminant, Alejandro Almela, Jaime Alvarez-Muniz, Juan Ammerman Yebra, Gioacchino Alex Anastasi, Luis A. Anchordoqui, Belén Andrada, Sofia Andringa, Carla Aramo, Paulo Ricardo Araújo Ferreira, Enrico Arnone, Juan Carlos Arteaga Velazquez, Hernán Gonzalo Asorey, Pedro Assis, Gualberto Avila, Emanuele Avocone, Alina Mihaela Badescu, Alena Bakalova, Alexandru Balaceanu, Felicia Barbato, Jose A. Bellido, Corinne Berat, Mario Edoardo Bertaina, Gopal Bhatta, Peter L. Biermann, Virginia Binet, Kathrin Bismark, Teresa Bister, Jonathan Biteau, Jiri Blazek, Carla Bleve, Johannes Blümer, Martina Bohacova, Denise Boncioli, Carla Bonifazi, Luan Bonneau Arbeletche, Nataliia Borodai, Jeffrey Brack, Thomas Bretz, P. Gabriel Brichetto Orchera, Florian Lukas Briechle, Peter Buchholz, Antonio Bueno, Stijn Buitink, Mario Buscemi, Max Büsken, Anthony Bwembya, Karen S. Caballero-Mora, Lorenzo Caccianiga, Ioana Caracas, Rossella Caruso, Antonella Castellina, Fernando Catalani, Gabriella Cataldi, Lorenzo Cazon, Marcos Cerda, Jose Augusto Chinellato, Jiří Chudoba, Ladislav Chytka, Roger W Clay, Agustín Cobos Cerutti, Roberta Colalillo, Alan Coleman, Maria Rita Coluccia, Rúben Conceição, Antonio Condorelli, Giovanni Consolati, Fernando Contreras, Fabio Convenga, Diego Correia dos Santos, Corbin Covault, Markus Cristinziani, Sergio Dasso, Kai Daumiller, Bruce R. Dawson, Jarryd A. Day, Rogerio M. de Almeida, Joaquin de Jesus, Sijbrand J. de Jong, João de Mello Neto, Ivan De Mitri, Jaime de Oliveira, Danelise de Oliveira Franco, Francesco de Palma, Vitor de Souza, Emanuele De Vito, Antonino Del Popolo, Olivier Deligny, Luca Deval, Armando di Matteo, Madalina Dobre, Carola Dobrigkeit, Juan Carlos D'Olivo, Luis Miguel Domingues Mendes, Rita Cassia dos Anjos, Maria Teresa Dova, Jan Ebr, Mohamed Eman, Ralph Engel, Italo Epicoco, Martin Erdmann, Carlos O. Escobar, Alberto Etchegoyen, Heino Falcke, John Farmer, Glennys R. Farrar, Anderson Campos Fauth, Norberto Fazzini, Fridtjof Feldbusch, Francesco Fenu, Brian Fick, Juan Manuel Figueira, Andrej Filipcic, Thomas Fitoussi, Tomáš Fodran, Toshihiro Fujii, Alan Fuster, Cristina Galea, Claudio Galelli, Beatriz García, Hartmut Gemmeke, Flavia Gesualdi, Alexandru Gherghel-Lascu, Piera Luisa Ghia, Ugo GIACCARI, Marco Giammarchi, Jonas Glombitza, Fabian Gobbi, Fernando Gollan, Geraldina Golup, Mariano Gómez Berisso, Primo F. Gómez Vitale, Juan Pablo Gongora, Juan Manuel González, Nicolas Martin Gonzalez, Isabel Goos, Dariusz Gora, Alessio Gorgi, Marvin Gottowik, Trent D. Grubb, Fausto Guarino, Germano Guedes, Eleonora Guido, Steffen Traugott Hahn, Petr Hamal, Matías Rolf Hampel, Patricia María Hansen, Diego Harari, Violet M. Harvey, Andreas Haungs, Thomas Hebbeker, Dieter Heck, Carlos Hojvat, Jörg R. Hörandel, Pavel Horvath, Miroslav Hrabovsky, Tim Huege, Antonio Insolia, Paula Gina Isar, Petr Janecek, Jeffrey A. Johnsen, Jakub Jurysek, Alex Kääpä, Karl-Heinz Kampert, Bianca Keilhauer, Abha Khakurdikar, Varada Varma Kizakke Covilakam, Hans Klages, Matthias Kleifges, Jonny Kleinfeller, Felix Knapp, Norbert Kunka, Bruno L. Lago, Niklas Langner, Marcelo Augusto Leigui de Oliveira, Vladimir Lenok, Antoine Letessier-Selvon, Isabelle Lhenry-Yvon, Domenico Lo Presti, Luis LOPES, Rebeca López, Lu Lu, Quentin Luce, Jon Paul Lundquist, Allan Machado Payeras, Giovanni Mancarella, Dusan Mandat, Bradley C. Manning, Julien Manshanden, Paul Mantsch, Sullivan Marafico, Federico Maria Mariani, Analisa Mariazzi, Ioana Maris, Giovanni Marsella, Daniele Martello, Sara Martinelli, Oscar Martínez Bravo, Miguel Alexandre Martins, Massimo Mastrodicasa, Hermann-Josef Mathes, James Matthews, Giorgio Matthiae, Eric William Mayotte, Sonja Mayotte, Peter Mazur, Gustavo Medina-Tanco, Diego Melo, Alexander Menshikov, Stanislav Michal, Maria Isabel Micheletti, Lino Miramonti, Silvia Mollerach, François Montanet, Leonel Morejon, Carlo Morello, Ana L. Müller, Katharine Mulrey, Roberto Mussa, Marco Stein Muzio, Wilson M. Namasaka, Alina Nasr-Esfahani, Lukas Nellen, Gabriela Nicora, Mihai Niculescu-Oglinzanu, Marcus Niechciol, Dave Nitz, Ian Norwood, Dalibor Nosek, Vladimír Novotný, Libor Nozka, Achille Nucita, Luis A. Nunez, Cainã Oliveira, Miroslav Palatka, Juan Pallotta, Gonzalo Parente, Alejandra Parra, Jannis Pawlowsky, Miroslav Pech, Jan Pękala, Rodrigo Pelayo, Edyvania Emily Pereira Martins, Johnnier Perez Armand, Carmina Pérez Bertolli, Lorenzo Perrone, Sergio Petrera, Camilla Petrucci, Tanguy Pierog, Mário Pimenta, Manuel Platino, Bjarni Pont, Mart Pothast, Paolo Privitera, Michael Prouza, Andrew Puyleart, Sven Querchfeld, Julian Rautenberg, Diego Ravignani, Maximilian Reininghaus, Jan Ridky, Felix Riehn, Markus Risse, Vincenzo Rizi, Washington Rodrigues de Carvalho, Jorge Rubén Rodriguez Rojo, Matías J. Roncoroni, Simone Rossoni, Markus Roth, Esteban Roulet, Adrian Rovero, Philip Ruehl, Alexandra Saftoiu, Mohit Saharan, Francesco Salamida, Humberto Ibarguen Salazar, Gaetano Salina, Jose Sanabria Gomez, Federico Andrés Sánchez, Edivaldo Moura Santos, Eva Santos, Fred Sarazin, Raul Sarmento, Ricardo Sato, Pierpaolo Savina, Christoph M. Schäfer, Viviana Scherini, Harald Schieler, Martin Schimassek, Michael Schimp, Felix Schlüter, David Schmidt, Olaf Scholten, Harm Schoorlemmer, Petr Schovanek, Frank G. Schröder, Josina Schulte, Tobias Schulz, Sergio J Sciutto, Marina Scornavacche, Alberto Segreto, Srijan Sehgal, Shima Ujjani Shivashankara, Guenter Sigl, Gaia Silli, Octavian Sima, Raluca Smau, Radomir Smida, Paul Sommers, Jorge F. Soriano, Ruben Squartini, Maximilian Stadelmaier, Denis Stanca, Samo Stanič, Jaroslaw Stasielak, Patrick Stassi, Maximilian Straub, Alexander Streich, Mauricio Suárez-Durán, Tristan Sudholz, Tiina Suomijarvi, A. Daniel Supanitsky, Zbigniew Szadkowski, Alex Tapia, Carla Taricco, Charles Timmermans, Olena Tkachenko, Petr Tobiska, Carlos J. Todero Peixoto, Bernardo Tomé, Zoé Torrès, Andres Travaini, Petr Travnicek, Matias Jorge Tueros, Ralf Ulrich, Michael Unger, Lukáš Vaclavek, Martin Vacula, Jose F. Valdés Galicia, Laura Valore, Enrique Varela, Adriana Vásquez-Ramírez, Darko Veberic, Cynthia Ventura, Indira D. Vergara Quispe, Valerio Verzi, Jakub Vicha, Jacco Vink, Serguei Vorobiov, Hernan Wahlberg, Clara Keiko Oliveira Watanabe, Alan Watson, Andreas Weindl, Lawrence Wiencke, Henryk Wilczyński, David Wittkowski, Brian Wundheiler, Alexey Yushkov, Orazio Zapparrata, Enrique Zas, Danilo Zavrtanik, Marko Zavrtanik, and Lukas Zehrer
Published: 2022
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4. SOCIAL MEDIA TOOLS AND CUSTOMER VALUE COCREATION: A CASE OF ZIMBABWE STATE UNIVESITIES

Author: Ronald Nyamukuwa, Peter Mazuruse, and Joshua Simuka
Subjects: social media, universities, social networks, co-creation, customer, Technology, Engineering (General). Civil engineering (General), TA1-2040
Abstract: Social media has made an impact as a category of online discussion where organisations and people create content, share it and network at an increasing rate. Customer cocreation is a hot topic among universities, students and other stakeholders. The main aim of this dissertation was to establish the implications of social media technologies as tools for value cocreation in state universities in Zimbabwe. The study adopted the positivist philosophy and therefore made use of quantitative research design in answering research questions. Sixty selfadministered questionnaires for state universities were used for data collection. The data was analysed statistically using Statistical Package for Social Sciences and SmartPLS3. Results of this study indicate that customer value co-creation and stakeholder engagements statistically significantly influence use of social media by universities. These results imply that universities must embrace the use of social media to unlock value from the university activities. The study contributes to literature by extending the effect of social media discussion to the university environment. This was important as it brings in the importance of social networks in universities in the country. The study recommends state universities must be educated of the benefits of social media in customer engagement, digital interaction and co-creation. Future studies could focus on developing models to enhance maximum utilisation of social media in universities. Furthermore, the sample should also include students’ perceptions.
Published: 2023
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5. Intracellular ice formation in mouse zygotes and early morulae vs. cooling rate and temperature-experimental vs. theory

Author: Zhang Zhenqiang, Peter Mazur, Shuyan Jiang, Shu Wang, Jiaqi Li, Yanbin Shi, Feng Yuan, Estefania Paredes, Chao Ma, Bo Jin, Juan Qiu, Shinsuke Seki, and Xiaoguang Shao
Subjects: Ethylene Glycol, Zygote, Biology, Morula, Article, General Biochemistry, Genetics and Molecular Biology, High temperature flasher, Andrology, Mice, 03 medical and health sciences, Cryoprotective Agents, 0302 clinical medicine, Freezing, medicine, Extracellular, Animals, Dehydration, Low temperature flasher, Cryopreservation, Extracellular ice formation, Mice, Inbred ICR, 030219 obstetrics & reproductive medicine, Strain (chemistry), Cooling rate, Ice, Temperature, 0402 animal and dairy science, IIf, Embryo, 04 agricultural and veterinary sciences, General Medicine, medicine.disease, 040201 dairy & animal science, Intracellular ice formation, Kinetics, Crystallography, Female, General Agricultural and Biological Sciences, Intracellular
Abstract: In this study, mature female mice of the ICR strain were induced to superovultate, mated, and collected at either zygote or early morula stages. Embryos suspended in 1 M ethylene glycol in PBS containing 10 mg/L Snomax for 15 min, then transferred in sample holder to Linkam cryostage, cooled to and seeded at 7 °C, and then observed and photographed while being cooled to −70 °C at 0.5–20 °C/min. Intracellular ice formation (IIF) was observed as abrupt ‘‘flashing’’. Two types of flashing or IIF were observed in this study. Extracellular freezing occurred at a mean of −7.7 °C. In morulae, about 25% turned dark within ±1 °C of extracellular ice formation (EIF). These we refer to as “high temperature’’ flashers. In zygotes, there were no high temperature flashers. All the zygotes flashed at temperatures well below the temperature for EIF. Presumably high temperature flashers were a consequence of membrane damage prior to EIF or damage from EIF. We shall not discuss them further. In the majority of cases, IIF occurred well below −7.7 °C; these we call ‘‘low temperature’’ flashers. None flashed with cooling rate (CR) of 0.5 °C/min in either zygotes or morulae. Nearly all flashed with CR of 4 °C/min or higher, but the distribution of temperatures is much broader with morulae than with zygotes. Also, the mean flashing temperature is much higher with morulae (−20.9 °C) than with zygotes (−40.3 °C). We computed the kinetics of water loss with respect to CR and temperature in both mouse zygotes and in morulae based on published estimates of Lp and it is Ea. The resulting dehydration curves combined with knowledge of the embryo nucleation temperature permits an estimate of the likelihood of IIF as a function of CR and subzero temperature. The agreement between these computed probabilities and the observed values are good.
Published: 2016
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6. Physical parameters, modeling, and methodological details in using IR laser pulses to warm frozen or vitrified cells ultra-rapidly

Author: Peter Mazur and Frederick W. Kleinhans
Subjects: Materials science, Light, chemistry.chemical_element, Nanotechnology, Article, General Biochemistry, Genetics and Molecular Biology, law.invention, Heating, Mice, Optics, law, Thermal, Animals, Vitrification, business.industry, Lasers, General Medicine, Radius, Carbon black, Models, Theoretical, Laser, India ink, Carbon, chemistry, Nd:YAG laser, Oocytes, General Agricultural and Biological Sciences, business
Abstract: We report additional details of the thermal modeling, selection of the laser, and construction of the Cryo Jig used for our ultra-rapid warming studies of mouse oocytes (B Jin, FW Kleinhans, Peter Mazur, Cryobiology 68 (2014) 419–430). A Nd:YAG laser operating at 1064 nm was selected to deliver short 1 msec pulses of sufficient power to produce a warming rate of 1 × 107 °C/min from –190°C to 0°C. A special Cryo Jig was designed and built to rapidly remove the sample from LN2 and expose it to the laser pulse. India ink carbon black particles were required to increase the laser energy absorption of the sample. The thermal model reported here is more general than that previously reported. The modeling reveals that the maximum warming rate achievable via external warming across the cell membrane is proportional to (1/R2) where R is the cell radius.
Published: 2015
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7. Survivals of mouse oocytes approach 100% after vitrification in 3-fold diluted media and ultra-rapid warming by an IR laser pulse

Author: Frederick W. Kleinhans, Peter Mazur, and Bo Jin
Subjects: Osmosis, Fold (higher-order function), Cell Survival, Infrared Rays, Ir laser, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Cryopreservation, Mice, Cryoprotective Agents, Botany, medicine, Animals, Vitrification, Dehydration, Pulse (signal processing), Lasers, Ice, Equipment Design, General Medicine, medicine.disease, Oocytes, Biophysics, Female, General Agricultural and Biological Sciences, Osmotic dehydration
Abstract: Vitrification is the most sought after route to the cryopreservation of animal embryos and oocytes and other cells of medical, genetic, and agricultural importance. Current thinking is that successful vitrification requires that cells be suspended in and permeated by high concentrations of protective solutes and that they be cooled at very high rates to below − 100°C. We report here that neither of these beliefs holds for mouse oocytes. Rather, we find that if mouse oocytes are suspended in media that produce considerable osmotic dehydration before vitrification and are subsequently warmed at ultra high rates (10,000,000°C/min) achieved by a laser pulse, nearly 100% will survive even when cooled rather slowly and when the concentration of solutes in the medium is only 1/3rd of standard.
Published: 2014
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8. The role of universities in the development of smart cities. Case of Harare.

Author: Obert Chahele, Peter Mazuruse, and Charles Chitumba
Subjects: smart city, principal component analysis (pca), innovation hub, government, Technology, Engineering (General). Civil engineering (General), TA1-2040
Abstract: The role of institution of higher education in smart city initiatives is increasing with government`s intervention in the increase of innovation hubs in Zimbabwe. Curriculum alignment through education 5.0 which includes innovation and industrialization is promoting an atmosphere for research and development (Ministry of Higher and Tertiary Education Science and Technology Development, 2019). As a result, a principal component analyses approach was conducted in determining factors which enhance universities` engagement in smart city developments using varimax approach of rotation space (Mishra et al., 2017; Leech et al, 2020). Qualitative approach was conducted on 390 respondents from various universities in Zimbabwe where reliability tests indicated 83% degree at 95% confidence interval using Kaiser Meyer Olkin`s measure of selection adequacy (Bonett and Wright, 2015); (Taber, 2018) . Factors which enhance universities to take part in smart city initiatives were extracted which are smart city education, innovation hubs, financial institutions and government support (Ransom, 2015; Sambuli and Whitt, 2017).
Published: 2022
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9. A preliminary study of osmotic dehydration in zebrafish embryos: Implications for vitrification and ultra-fast laser warming

Author: Estefania Paredes, Peter Mazur, and Michelle H. Connolly
Subjects: 0301 basic medicine, Osmosis, Sucrose, animal structures, Embryo, Nonmammalian, Cryoprotectant, Epiboly, Biology, General Biochemistry, Genetics and Molecular Biology, Cryopreservation, Andrology, 03 medical and health sciences, Mice, Cryoprotective Agents, Embryo cryopreservation, Botany, medicine, Animals, Vitrification, Dehydration, Desiccation, Zebrafish, 030102 biochemistry & molecular biology, Water, Embryo, General Medicine, medicine.disease, 030104 developmental biology, embryonic structures, General Agricultural and Biological Sciences, Osmotic dehydration
Abstract: To date, traditional cryopreservation techniques have not been amenable to zebrafish (Danio rerio) embryos, due in part to their large yolky eggs, which have a low surface to volume ratio and limited permeability to water and cryoprotectants. However, recent vitrification and ultra-rapid warming studies in mice have demonstrated successful preservation by dehydrating 85% or more of their total water content. We hypothesized that this approach may help overcome the barriers to embryo cryopreservation among D. rerio. The purpose of this study was to determine the osmotic tolerance limit of D. rerio embryos under conditions relevant to cryopreservation. We found that embryos undergoing gastrulation (30%–70% epiboly) were particularly sensitive to osmotic dehydration/rehydration. By contrast, a subset of embryos dehydrated during or after segmentation (20–22 somite, prim 5) survived 3 h in a 2 M sucrose solution but exhibit developmental delay, edema and trunk necrosis 2–4 days post-treatment.
Published: 2016

10. Evidence for a mixed mass composition at the 'ankle' in the cosmic-ray spectrum

Author: S. Stanič, Denis Stanca, J. A.J. Matthews, Xavier Bertou, M. L. Díaz Castro, C. Porowski, Jakub Vicha, Francesca Zuccarello, Pedro Assis, R. Sato, Jose Chinellato, I. Jandt, Hermann-Josef Mathes, M. Ziolkowski, Denise Boncioli, Markus Risse, Muller, F. Canfora, J. Blazek, A. Tonachini, Antonio Bueno, M. Josebachuili, J.D. Sanabria Gomez, Eric Mayotte, A. C. Rovero, J. Biteau, P.F. Gómez Vitale, G. A. Anastasi, Kai Daumiller, Alberto Filevich, Peter Hansen, John Matthews, Christian Sarmiento-Cano, Gualberto Avila, W. Rodrigues de Carvalho, Marco Torri, Nicolás González, M. Gómez Berisso, R. C. Shellard, Leigui de Oliveira, Paul M. Mantsch, Diego Ravignani, J. R. Vázquez, P. Sanchez-Lucas, S. Vorobiov, Ingomar Allekotte, F. Sánchez, J. W. Cronin, Lorenzo Cazon, Peter Buchholz, R. Piegaia, I. Al Samarai, Ivo Nicolas Naranjo, Antonio Insolia, A. Aab, L. Caramete, Alina Mihaela Badescu, P. Heimann, Anderson Fauth, M. Zavrtanik, G. Marsella, R. Ramos-Pollant, Valerio Pirronello, G. Torralba Elipe, O. Ravel, P. van Bodegom, Angela V. Olinto, C. Di Giulio, S. Navas, I.M. Brancus, H. Glass, Marco Aglietta, Johannes Schumacher, Joshua A. Gordon, Bruno Daniel, Corinne Berat, R. Krause, Gaia Silli, A. Filipčič, Foteini Oikonomou, G. S. Varner, Alessio Gorgi, Fred Sarazin, H. Gemmeke, Lukas Nellen, M. I. Micheletti, L. A. S. Pereira, Maria Giller, J. J. Masías Meza, C. J. Todero Peixoto, A.E. Herve, Octavian Sima, Nataliia Borodai, D. Mockler, Manuel Platino, E.M. Holt, B. Wundheiler, A. Fuster, Q. Hasankiadeh, A. Saleh, Jeffrey Brack, J. F. Valdés Galicia, Olaf Scholten, Ioana Codrina Maris, I. De Mitri, Dieter Heck, Martin Urban, Hans Klages, H. Nožka, A. Chiavassa, Maria-Teresa Dova, M. R. Hampel, O. A. Taborda, Carlos Hojvat, Miroslav Palatka, A. Menshikov, Diego Harari, B. Gookin, S. Müller, Carola Dobrigkeit, M. Schauer, Humberto Ibarguen Salazar, Ricardo Vázquez, Antoine Letessier-Selvon, Ernesto Kemp, R. Legumina, P. H. Nguyen, Lawrence Wiencke, B. Sarkar, Sarka Wykes, C. Morello, E. M. Santos, G. Kukec Mezek, L. Molina-Bueno, M. Plum, Z. Zong, David Walz, Harald Schieler, O. Kambeitz, Jeffrey A. Johnsen, Sven Querchfeld, L. Perrone, Marco Giammarchi, Bruce R. Dawson, S. Quinn, Christian Glaser, J. Espadanal, Octavian Fratu, M. E. Bertaina, Alan Watson, Mihai Niculescu-Oglinzanu, Jonny Kleinfeller, Sergio Sciutto, L. Ochilo, M. Mallamaci, Alberto Segreto, Nicusor Arsene, D. Rogozin, J. de Oliveira, R.R. Prado, Alejandro Almela, P. Billoir, Tim Huege, Ana Martina Botti, Belén Andrada, J. Alvarez Castillo, G. C. Hill, R.C. dos Anjos, Lukas Middendorf, D. Pakk Selmi-Dei, F. Diogo, G. De Mauro, Henryk Wilczyński, Ralph Engel, J. J. Beatty, Norbert Kunka, D. Nitz, Günter Sigl, Silvia Mollerach, A. Śmiałkowski, Jörg R. Hörandel, Sutherland, Julian Rautenberg, Peter L. Biermann, F. Montanet, L. Niemietz, R. M. de Almeida, L. Tomankova, Christine Peters, Radomir Smida, Alberto Etchegoyen, John L. Harton, Peter Gorham, T. Paul, Paolo Privitera, Federico Suarez, A. Schulz, D. Reinert, A. López Casado, G. Matthiae, Andreas Weindl, D. Garcia-Pinto, Paul Sommers, Petr Schovanek, A. Di Matteo, Charles Timmermans, Luis A. Nunez, A. Blanco, P. Gouffon, N. Krohm, D. Torres Machado, L. Collica, P. Abreu, Brian Fick, Zbigniew Szadkowski, Alberto Daniel Supanitsky, D. Melo, Julien Aublin, A. Shadkam, M. J. Cooper, Miguel Mostafá, Mário Pimenta, Gregory R Snow, Pablo Ristori, Miroslav Pech, P. H. Kasper, Carlos Medina, M. Settimo, R. Ulrich, Rodrigo Pelayo, Stijn Buitink, E. Varela, D. Yelos, Andrej Dundovic, Marcus Niechciol, D. Martello, Luis A. Anchordoqui, Pavel Horvath, Danilo Zavrtanik, Lorenzo Caccianiga, V. M. Theodoro, Paula Gina Isar, F. Salesa Greus, G. Cataldi, Florian Gaté, Michael Unger, S. Jansen, Gero Müller, P. W. Younk, Sofia Andringa, Eun-Joo Ahn, P. Lautridou, C. Scarso, Elton J. G. Santos, Jiri Chudoba, Markus Roth, G. van Aar, Dusan Mandat, Q. Luce, V. de Souza, Alex Kääpä, Maria Rita Coluccia, A. van Vliet, Tanguy Pierog, R. Cester, Gustavo Medina-Tanco, Miroslav Hrabovský, L. del Peral, Jaroslaw Stasielak, Andreas Haungs, Matthias Kleifges, V. Verzi, Philipp Papenbreer, Colin Baus, Glennys R. Farrar, David Schmidt, J. Sorokin, K. H. Becker, H. Martinez, A. G. Mariazzi, A. Kuotb Awad, S. G. Blaess, C. Aramo, Sergio Dasso, Tristan Sudholz, Fausto Guarino, Juan Pallotta, R. López, B. Tome, C. Bleve, Alexandru Balaceanu, Petr Travnicek, Rodríguez-Frías, V. Scherini, Arnulfo Zepeda, Eduardo Quel, David Wittkowski, Laura Valore, Martín Miguel Freire, Thomas Harrison, Benoît Revenu, Germano Guedes, Danielle LaHurd, Olivier Deligny, P. Pieroni, Alan Coleman, T. Hebbeker, Vincenzo Rizi, Trent D. Grubb, G. Rodriguez Fernandez, Benedikt Zimmermann, Rúben Conceição, Toshihiro Fujii, M. Ambrosio, L. Lopes, J. Debatin, O. Martínez Bravo, Dariusz Glas, Juan Manuel Figueira, F. Arqueros, Alexandra Saftoiu, Tim Niggemann, Roberta Colalillo, J. Hulsman, B. Mitrica, Hernán Asorey, Francesco Strafella, Martina Bohacova, Patrick Allison, Heino Falcke, Jaime Alvarez-Muñiz, Alexandru Gherghel-Lascu, I. Lhenry-Yvon, A. Lucero, Juan Carlos D'Olivo, O. Wainberg, A. Valbuena-Delgado, Esteban Roulet, T. Suomijärvi, Karl-Heinz Kampert, Antonella Castellina, Piera Luisa Ghia, V. Novotny, Rossella Caruso, S. Mathys, M. Erfani, John Swain, Thomas Bretz, Ruben Squartini, I. A. Minaya, Corbin Covault, Peter Mazur, J. Pȩkala, Geraldina Golup, Alexander Grillo, S. J. De Jong, Katrin Link, Lino Miramonti, Ugo Giaccari, A. Tepe, J. R. T. de Mello Neto, M. Prouza, J. Rodriguez Rojo, Bianca Keilhauer, A. G. Chavez, F.G. Schröder, Enrique Zas, Fernando Contreras, Jesús Peña-Rodríguez, A. Dorofeev, L. Villaseñor, A. Bridgeman, S. J. Saffi, Markus Lauscher, F. Pedreira, J. Phuntsok, Raul Sarmento, M. Suarez Durán, H. Wahlberg, A. Parra, G. Parente, M. Trini, Johannes Schulz, Florian Lukas Briechle, A. Cancio, B. Caccianiga, Alexey Yushkov, Max Malacari, Lili Yang, Luca Latronico, Piotr Homola, Alex Tapia, Tobias Winchen, P. Lebrun, Karen S. Caballero-Mora, Martin Erdmann, Carla Bonifazi, Beatriz García, Roger W Clay, Stefano D'Amico, Jose A. Bellido, Daniel Kuempel, S. Sonntag, Carlos Escobar, Jaime Rosado, R.M. Kieckhafer, B. Vargas Cárdenas, I. Valiño, J. Neuser, Ivone F. M. Albuquerque, Ke Fang, I. Katkov, Richard Dallier, Gaetano Salina, A.M. van den Berg, Darko Veberič, Jan Ridky, Marc Weber, M. Buscemi, D. Nosek, Jan Ebr, Sergio Petrera, S. Messina, S. Coutu, Norberto Fazzini, Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Al Samarai, I., Albuquerque, I. F. M., Allekotte, I., Allison, P., Almela, A., Alvarez Castillo, J., Alvarez Muñiz, J., Ambrosio, M., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, Carla, Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero Mora, K. S., Caccianiga, B., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, MARIA RITA, Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., Dallier, R., D'Amico, Stefano, Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., de Mello Neto, J. R. T., DE MITRI, Ivan, de Oliveira, J., de Souza, V., Debatin, J., del Peral, L., Deligny, O., Di Giulio, C., Di Matteo, A., Díaz Castro, M. L., Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorofeev, A., dos Anjos, R. C., Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., García, B., Garcia Pinto, D., Gaté, F., Gemmeke, H., Gherghel Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Gómez Berisso, M., Gómez Vitale, P. F., González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Kukec Mezek, G., Kunka, N., Kuotb Awad, A., Lahurd, D., Latronico, L., Lauscher, M., Lautridou, P., Lebrun, P., Legumina, R., Leigui de Oliveira, M. A., Letessier Selvon, A., Lhenry Yvon, I., Link, K., Lopes, L., López, R., López Casado, A., Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, Giovanni, Martello, Daniele, Martinez, H., Martínez Bravo, O., Masías Meza, J. J., Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina Tanco, G., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Molina Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, G., Muller, M. A., Müller, S., Naranjo, I., Navas, S., Nellen, L., Neuser, J., Nguyen, P. H., Niculescu Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Pakk Selmi Dei, D., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña Rodriguez, J., Pereira, L. A. S., Perrone, Lorenzo, Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos Pollant, R., Rautenberg, J., Ravel, O., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., Rodrigues de Carvalho, W., Rodriguez Fernandez, G., Rodriguez Rojo, J., Rodríguez Frías, M. D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Salesa Greus, F., Salina, G., Sanabria Gomez, J. D., Sánchez, F., Sanchez Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento Cano, C., Sato, R., Scarso, C., Schauer, M., Scherini, Viviana, Schieler, H., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, Mariangela, Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Strafella, Francesco, Suarez, F., Suarez Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Timmermans, C., Todero Peixoto, C. J., Tomankova, L., Tomé, B., Tonachini, A., Torralba Elipe, G., Torres Machado, D., Torri, M., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Valbuena Delgado, A., Valdés Galicia, J. F., Valiño, I., Valore, L., van Aar, G., van Bodegom, P., van den Berg, A. M., van Vliet, A., Varela, E., Vargas Cárdenas, B., Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yelos, D., Younk, P., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., Zuccarello, F., Bleve, C., Colalillo, Roberta, Coluccia, M. R., D'Amico, S., De Mitri, I., Guarino, Fausto, Marsella, G., Martello, D., Pȩkala, J., Perrone, L., Scherini, V., Settimo, M., Strafella, F., Valore, Laura, Physics, Astronomy and Astrophysics Research Group, Elementary Particle Physics, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), and Pierre Auger Collaboration
Subjects: [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Nuclear and High Energy Physics, Proton, Pierre Auger Observatory, Cosmic Rays, Mass Composition, Astronomy, Astrophysics::High Energy Astrophysical Phenomena, Flux, FOS: Physical sciences, Cosmic ray, Ankle, Cosmic rays, Mass composition, Astrophysics, 01 natural sciences, Auger, Observatory, 0103 physical sciences, ddc:530, High Energy Physics, 010303 astronomy & astrophysics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Cherenkov radiation, Ciencias Exactas, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Range (particle radiation), 010308 nuclear & particles physics, OBSERVATÓRIOS, Astrophysics::Instrumentation and Methods for Astrophysics, Física, lcsh:QC1-999, Physique atomique et nucléaire, Experimental High Energy Physics, Física nuclear, Astrophysics - High Energy Astrophysical Phenomena, lcsh:Physics
Abstract: We report a first measurement for ultrahigh energy cosmic rays of the correlation between the depth of shower maximum and the signal in the water Cherenkov stations of air-showers registered simultaneously by the fluorescence and the surface detectors of the Pierre Auger Observatory. Such a correlation measurement is a unique feature of a hybrid air-shower observatory with sensitivity to both the electromagnetic and muonic components. It allows an accurate determination of the spread of primary masses in the cosmic-ray flux. Up till now, constraints on the spread of primary masses have been dominated by systematic uncertainties. The present correlation measurement is not affected by systematics in the measurement of the depth of shower maximum or the signal in the water Cherenkov stations. The analysis relies on general characteristics of air showers and is thus robust also with respect to uncertainties in hadronic event generators. The observed correlation in the energy range around the ‘ankle’ at lg⁡(E/eV)=18.5–19.0 differs significantly from expectations for pure primary cosmic-ray compositions. A light composition made up of proton and helium only is equally inconsistent with observations. The data are explained well by a mixed composition including nuclei with mass A>4. Scenarios such as the proton dip model, with almost pure compositions, are thus disfavored as the sole explanation of the ultrahigh-energy cosmic-ray flux at Earth., 0, SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2016
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11. The Temperature and Type of Intracellular Ice Formation in Preimplantation Mouse Embryos as a Function of the Developmental Stage1

Author: Shinsuke Seki and Peter Mazur
Subjects: Ethylene Glycol, Osmosis, Nucleation, Biology, Morula, Cryopreservation, Andrology, Mice, Cryoprotective Agents, Freezing, medicine, Animals, Blastocyst, Genetics, Aquaporin 3, Mice, Inbred ICR, Meiosis II, Ice, Embryogenesis, Gap Junctions, Embryo, IIf, Cell Biology, General Medicine, medicine.anatomical_structure, Reproductive Medicine, Oocytes, Ice nucleus, Female, Research Article
Abstract: Our studies the past 5 yr have concentrated on intracellular ice formation (IIF) in mature mouse oocytes at the metaphase stage of meiosis II. Here we report an analogous investigation of the temperature of intracellular ice nucleation in preimplantation embryo stages from one-cell to early morula suspended in 1 M ethylene glycol/PBS and cooled at 20 degrees C/min to -70 degrees C. Physical modeling indicates that oocytes and preimplantation embryos undergo very little osmotic shrinkage at that cooling rate. As a consequence, their interior becomes increasingly supercooled until the supercooling is abruptly terminated by IIF. Four categories of IIF were observed. The first two were 1) those undergoing IIF at temperatures well below the temperature of external ice formation (EIF; -7.2 degrees C) vs. 2) those undergoing IIF within 1 degrees C of the EIF temperature. The other two categories were those multicellular stages in which 3) all the blastomeres underwent IIF simultaneously vs. 4) those in which blastomeres underwent IIF sequentially. Embryos in categories 1 and 3 constituted the majority (80-90%), and for them, the mean IIF temperatures of one-cell, two-cell, four- to six-cell, and early eight-cell ranged from -37 degrees C to -43 degrees C, temperatures that indicate that IIF is a consequence of homogeneous nucleation. However, the IIF nucleation temperature of early morulae in categories 1 and 3 was markedly higher; namely, -23.1 +/- 1.5 degrees C. This marked rise in nucleation temperature coincides with the appearance of aquaporin 3 and gap junctions in early morulae (compacted eight-cell), and is presumably causally related.
Published: 2010
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12. Determination of the water permeability (Lp) of mouse oocytes at −25°C and its activation energy at subzero temperatures

Author: Frederick W. Kleinhans and Peter Mazur
Subjects: Ethylene Glycol, Time Factors, Cell Survival, Nucleation, Thermodynamics, Activation energy, Models, Biological, Article, Permeability, General Biochemistry, Genetics and Molecular Biology, Mice, chemistry.chemical_compound, Permeability measurements, Animals, Holding time, Ice formation, Hold time, Water, General Medicine, Cold Temperature, Crystallography, chemistry, Permeability (electromagnetism), Oocytes, Female, General Agricultural and Biological Sciences, Ethylene glycol
Abstract: Typically, subzero permeability measurements are experimentally difficult and infrequently reported. Here we report an approach we have applied to mouse oocytes. Interrupted cooling involves rapidly cooling oocytes (50 degrees C/min) to an intermediate temperature above the intracellular nucleation zone, holding them for up to 40 min while they dehydrate, and then rapidly cooling them to -70 degrees C or below. If the intermediate holding temperature and holding time are well chosen, high post thaw survival of the oocytes is possible because the freezable water is removed during the hold. The length of time required for the exit of the freezable water allows the water permeability at that temperature to be determined. These experiments used 1.5M ethylene glycol in PBS and included a transient hold of 2 min for equilibration at -10 degrees C, just below the extracellar ice formation temperature. We obtain an Lp=1.8 x 10(-3)microm min(-1)atm(-1) at -25 degrees C based on a hold time of 30 min yielding 80% survival and the premise that most of the freezable water is removed during the 30 min hold. If we assume that the water permeability is a continuous function of temperature and that its Ea changes at 0 degrees C, we obtain a subzero Ea of 21 kcal/mol; higher than the suprazero value of 14 kcal/mol. A number of assumptions are required for these water loss calculations and the resulting value of Lp can vary by up to a factor of 2, depending on the choices make.
Published: 2009
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13. Effect of Warming Rate on the Survival of Vitrified Mouse Oocytes and on the Recrystallization of Intracellular Ice1

Author: Shinsuke Seki and Peter Mazur
Subjects: Intracellular Fluid, Sucrose, Cryoprotectant, Cell Survival, Biology, Cryopreservation, Andrology, Mice, Cryoprotective Agents, Acetamides, medicine, Animals, Ficoll, Vitrification, Mice, Inbred ICR, Ice crystals, Ice, Temperature, Recrystallization (metallurgy), Cell Biology, General Medicine, Anatomy, Oocyte, medicine.anatomical_structure, Reproductive Medicine, Oocytes, Ethylene Glycols, Female, Crystallization, Warming rate, Intracellular, Research Article
Abstract: Successful cryopreservation demands there be little or no intracellular ice. One procedure is classical slow equilibrium freezing, and it has been successful in many cases. However, for some important cell types, including some mammalian oocytes, it has not. For the latter, there are increasing attempts to cryopreserve them by vitrification. However, even if intracellular ice formation (IIF) is prevented during cooling, it can still occur during the warming of a vitrified sample. Here, we examine two aspects of this occurrence in mouse oocytes. One took place in oocytes that were partly dehydrated by an initial hold for 12 min at -25 degrees C. They were then cooled rapidly to -70 degrees C and warmed slowly, or they were warmed rapidly to intermediate temperatures and held. These oocytes underwent no IIF during cooling but blackened from IIF during warming. The blackening rate increased about 5-fold for each five-degree rise in temperature. Upon thawing, they were dead. The second aspect involved oocytes that had been vitrified by cooling to -196 degrees C while suspended in a concentrated solution of cryoprotectants and warmed at rates ranging from 140 degrees C/min to 3300 degrees C/min. Survivals after warming at 140 degrees C/min and 250 degrees C/min were low (30%). Survivals after warming ator =2200 degrees C/min were high (80%). When warmed slowly, they were killed, apparently by the recrystallization of previously formed small internal ice crystals. The similarities and differences in the consequences of the two types of freezing are discussed.
Published: 2008
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14. Kinetics and activation energy of recrystallization of intracellular ice in mouse oocytes subjected to interrupted rapid cooling

Author: Shinsuke Seki and Peter Mazur
Subjects: Intracellular Fluid, Time Factors, Cryobiology, Recrystallization (geology), Kinetics, Activation energy, Article, General Biochemistry, Genetics and Molecular Biology, Cryopreservation, Degree (temperature), Mice, Animals, Transition Temperature, Mice, Inbred ICR, Chemistry, Ice, General Medicine, Darkness, Cold Temperature, Crystallography, Oocytes, Biophysics, Female, Crystallization, General Agricultural and Biological Sciences, Algorithms, Intracellular
Abstract: Intracellular ice formation (IIF) is almost invariably lethal. In most cases, it results from the too rapid cooling of cells to below -40 degrees C, but in some cases it is manifested, not during cooling, but during warming when cell water that vitrified during cooling first devitrifies and then recrystallizes during warming. Recently, Mazur et al. [P. Mazur, I.L. Pinn, F.W. Kleinhans, Intracellular ice formation in mouse oocytes subjected to interrupted rapid cooling, Cryobiology 55 (2007) 158-166] dealt with one such case in mouse oocytes. It involved rapidly cooling the oocytes to -25 degrees C, holding them 10 min, rapidly cooling them to -70 degrees C, and warming them slowly until thawed. No IIF occurred during cooling but intracellular freezing, as evidenced by blackening of the cells, became detectable at -56 degrees C during warming and was complete by -46 degrees C. The present study differs in that the oocytes were warmed rapidly from -70 degrees C to temperatures between -65 and -50 degrees C and held for 3-60 min. This permitted us to determine the rate of blackening as function of temperature. That in turn allowed us to calculate the activation energy (E(a)) for the blackening process; namely, 27.5 kcal/mol. This translates to about a quadrupling of the blackening rate for every 5 degrees C rise in temperature. These data then allowed us to compute the degree of blackening as a function of temperature for oocytes warmed at rates ranging from 10 to 10,000 degrees C/min. A 10-fold increase in warming rate increased the temperature at which a given degree of blackening occurred by 8 degrees C. These findings have significant implications both for cryobiology and cryo-electron microscopy.
Published: 2008
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15. Relationship between intracellular ice formation in oocytes of the mouse and Xenopus and the physical state of the external medium—A revisit

Author: Peter Mazur and Frederick W. Kleinhans
Subjects: Ternary numeral system, Cryobiology, Chromatography, Sodium, Analytical chemistry, chemistry.chemical_element, General Medicine, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, chemistry, Phase (matter), Glycerol, Melting point, General Agricultural and Biological Sciences, Ethylene glycol, Phase diagram
Abstract: We have previously reported that intracellular ice formation (IIF) in mouse oocytes suspended in glycerol/PBS solutions or ethylene glycol (EG)/PBS solutions and rapidly cooled to −50 °C or below occurs at temperatures where a critical fraction of the external water remains unfrozen [P. Mazur, S. Seki, I.L. Pinn, F.W. Kleinhans, K. Edashige, Extra- and intracellular ice formation in mouse oocytes, Cryobiology 51 (2005) 29–53; P. Mazur, I.L. Pinn, F.W. Kleinhans, The temperature of intracellular ice formation in mouse oocytes vs. the unfrozen fraction at that temperature, Cryobiology 54 (2007) 223–233]. For mouse oocytes in PBS or glycerol/PBS that fraction is 0.06; for oocytes in EG that fraction was calculated to be 0.13, more than double. The fractions unfrozen are computed from ternary phase diagrams. In the previous publication, we used the EG data of Woods et al. [E.J. Woods, M.A.J. Zieger, D.Y. Gao, J.K. Critser, Equations for obtaining melting points for the ternary system ethylene glycol/sodium chloride/Water and their application to cryopreservation., Cryobiology 38 (1999) 403–407]. Since then, we have determined that ternary phase diagrams for EG/NaCl/water synthesized by summing binary phase data for EG/water NaCl/water gives substantially different curves, which seem more realistic [F.W. Kleinhans, P. Mazur, Comparison of actual vs. synthesized ternary phase diagrams for solutes of cryobiological interest, Cryobiology 54 (2007) 212–222]. Unfrozen fractions at the temperatures of IIF computed from these synthesized phase diagrams are about half of those calculated from the Woods et al. data, and are in close agreement with the computations for glycerol; i.e., IIF occurs when about 92–94% of the external water is frozen. A parallel paper was published by Guenther et al. [J.F. Guenther, S. Seki, F.W. Kleinhans, K. Edashige, D.M. Roberts, P. Mazur, Extra-and intra-cellular ice formation in Stage I and II Xenopus laevis oocytes, Cryobiology 52 (2006) 401–416] on IIF in oocytes of the frog Xenopus . It too examined whether the temperatures of IIF were related to the unfrozen fractions at those temperatures. It also used the Woods et al. ternary phase data to calculate the unfrozen fractions for EG solutions. As reported here, once again the values of these unfrozen fractions are substantially different from those calculated using synthesized phase diagrams. With the latter, the unfrozen fractions at IIF become very similar for EG and glycerol.
Published: 2008
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16. Roles of intracellular ice formation, vitrification of cell water, and recrystallisation of intracellular ice on the survival of mouse embryos and oocytes

Author: Estefania Paredes and Peter Mazur
Subjects: Reproductive technology, Biology, Cryopreservation, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Human fertilization, Genetics, medicine, Vitrification, Molecular Biology, 030219 obstetrics & reproductive medicine, 0402 animal and dairy science, Embryo culture, 04 agricultural and veterinary sciences, Anatomy, Oocyte, 040201 dairy & animal science, medicine.anatomical_structure, Reproductive Medicine, Amorphous ice, Biophysics, Animal Science and Zoology, Intracellular, Developmental Biology, Biotechnology
Abstract: Mazur and collaborators began examining the validity of initial views regarding mouse oocyte and embryo vitrification and found that most are partially or fully wrong. First, the relative effects of warming and cooling rates on the survival of mouse oocytes subjected to a vitrification procedure were determined. The high sensitivity to warming rate strongly suggests that the lethality of slow warming is a consequence of either the crystallisation of intracellular glassy water during warming or the recrystallisation during slow warming of small intracellular crystals that had formed during cooling. Warming rates of 107°C min–1 were achieved in 0.1-µL drops of ethylene glycol–acetamide–Ficoll–sucrose (EAFS) solution plus a small amount of India ink on Cryotops warmed using an infrared laser pulse. Under these conditions, survival rates of 90% were obtained even when mouse oocytes were suspended in 0.3× EAFS, a concentration that falls in the range that many cells can tolerate. A second important finding was that the survival of oocytes is more dependent on the osmotic withdrawal of much of the intracellular water before vitrification than it is on the penetration of cryoprotective solutes into the cells. Herein we review the roles of internal ice formation, vitrification and recrystallisation. It remains to be seen how widely these findings will be applicable to other types of cells and tissues from other species.
Published: 2016

17. Energy estimation of cosmic rays with the Engineering Radio Array of the Pierre Auger Observatory

Author: Pierre Auger Collaboration (Alexander Aab (Siegen, U. )., Pedro Abreu (LIP, Lisbon &amp, Lisbon, IST), Marco Aglietta (IFSI, Turin), Eun-Joo Ahn (Fermilab), Imen Al Samarai (Orsay, IPN), Ivone Albuquerque (Sao Paulo, U. )., Ingomar Allekotte (Centro Atomico Bariloche &amp, Balseiro, Inst., San Carlos de Bariloche), Patrick Allison (Ohio State, U. )., Alejandro Almela, (U. Tech. Natl., Argentina), Jesus Alvarez Castillo (Mexico, U. )., Jaime Alvarez-Muñiz (Santiago de Compostela, U. )., Rafael Alves Batista (Hamburg, U., II), Inst. Theor. Phys., amp, INFN, Michelangelo Ambrosio (Naples U., Naples), Amin Aminaei (Nijmegen, U., IMAPP), INFN, Gioacchino Alex Anastasi (Catania U., Catania), Luis Anchordoqui (Lehman, Coll. )., Sofia Andringa (LIP, INFN, Carla Aramo (Naples U., Fernando Arqueros (Madrid, U. )., Nicusor Arsene (Bucharest, U. )., Hernán Gonzalo Asorey (Centro Atomico Bariloche &amp, San Carlos de Bariloche &amp, Cantabria, U., Santander), Pedro Assis (LIP, Julien Aublin (Paris, U., VI-VII), Gualberto Avila (Pierre Auger, Observ. )., Nafiun Awal (New York, U. )., Alina Mihaela Badescu (Bucharest, Polytechnic, Inst. )., Colin Baus (KIT, Karlsruhe, EKP), Jim Beatty (Ohio State, U. )., Karl Heinz Becker (Wuppertal, U. )., Jose A Bellido (Adelaide, U. )., Corinne Berat (LPSC, Grenoble), Mario Edoardo Bertaina (IFSI, Xavier Bertou (Centro Atomico Bariloche &amp, Peter Biermann (Bonn, Max Planck, Inst., Radioastro, n. )., Pierre Billoir (Paris, U., Simon G Blaess (Adelaide, U. )., Alberto Blanco (LIP, Miguel Blanco (Paris, U., Jiri Blazek (Prague, Ins, t. Phys. )., INFN, Carla Bleve (Salento U., Lecce), Hans Blümer (KIT, Karlsruhe, IKP &amp, KIT, Karlsruhe, IKP), Martina Boháčová (Prague, Denise Boncioli (Gran Sasso), Carla Bonifazi (Rio de Janeiro Federal, U. )., Nataliia Borodai (Cracow, INP), Jeffrey Brack (Colorado State, U. )., Iliana Brancus (Bucharest, IFIN-HH), Thomas Bretz (Aachen, Tec, h. Hochsch. )., Ariel Bridgeman (KIT, Pedro Brogueira (LIP, Peter Buchholz (Siegen, U. )., CAFPE, Antonio Bueno (Granada U., Granada), Stijn Buitink (Nijmegen, U., INFN, Mario Buscemi (Naples U., Karen, S Caballero-Mora (Unlisted, FR), INFN, Barbara Caccianiga (Milan U., Milan), Lorenzo Caccianiga (Paris, U., Marina Candusso (Rome, U., Tor Vergata &amp, INFN, Rome2), Laurentiu Caramete (Bucharest, Space Sciences), Inst., Caruso, R, Antonella Castellina (IFSI, INFN, Gabriella Cataldi (Salento U., Lorenzo Cazon (LIP, INFN, Rosanna Cester (Turin U., Alan, G Chavez (IFM-UMSNH, Michoacan), Andrea Chiavassa (IFSI, Jose Augusto Chinellato (Campinas State, U. )., Jiri Chudoba (Prague, INFN, Marco Cilmo (Naples U., Roger W Clay (Adelaide, U. )., INFN, Giuseppe Cocciolo (Salento U., INFN, Roberta Colalillo (Naples U., Alan Coleman (Penn State, U. )., INFN, Laura Collica (Milan U., INFN, Maria Rita Coluccia (Salento U., Ruben Conceição (LIP, Fernando Contreras (Pierre Auger, Observ. )., Mathew J Cooper (Adelaide, U. )., Alain Cordier (Orsay, LAL), Stephane Coutu (Penn State, U. )., Corbin Covault (Case Western Reserve, U. )., James Cronin (Chicago, U., EFI), Richard Dallier (Station Radioastronomy, Nancay &amp, SUBATECH, Nantes), Bruno Daniel (Campinas State, U. )., Buenos Aires, Sergio Dasso (Buenos Aires U., IAFE), Kai Daumiller (KIT, Bruce R Dawson (Adelaide, U. )., Rogerio, M de Almeida (Niteroi, Fluminense, U. )., Sijbrand J de Jong (Nijmegen, U., IMAPP &amp, NIKHEF, Amsterdam), Giuseppe De Mauro (Nijmegen, U., Joao de Mello Neto (Rio de Janeiro Federal, U. )., INFN, Ivan De Mitri (Salento U., Jaime de Oliveira (Niteroi, Vitor de Souza (Sao Paulo, U., Sao, Carlos), Luis del Peral (Alcala de Henares, U. )., Olivier Deligny (Orsay, Niraj Dhital (Michigan, Tech. U. )., Claudio Di Giulio (Rome, U., INFN, Armando Di Matteo (L'Aquila U., Aquila), Johana Chirinos Diaz (Michigan, Tech. U. )., Mary Lucia Díaz Castro (Campinas State, U. )., Francisco Diogo (LIP, Carola Dobrigkeit (Campinas State, U. )., Wendy Docters (Groningen, KVI), Juan Carlos D'Olivo (Mexico, U. )., Alexei Dorofeev (Colorado State, U. )., Qader Dorosti Hasankiadeh (KIT, Rita dos Anjos (Sao Paulo, U., Maria Teresa Dova (La Plata, U. )., Jan Ebr (Prague, Ralph Engel (KIT, Martin Erdmann (Aachen, Mona Erfani (Siegen, U. )., Fermilab), Carlos O Escobar (Campinas State U., Joao Espadanal (LIP, Alberto Etchegoyen, (U. Tech. Natl., Heino Falcke (Nijmegen, U., Amsterdam &amp, ASTRON, Dwingeloo), Ke Fang (Chicago, U., Glennys Farrar (New York, U. )., Anderson Fauth (Campinas State, U. )., Norberto Fazzini (Fermilab), Andrew P Ferguson (Case Western Reserve, U. )., Brian Fick (Michigan, Tech. U. )., Juan Manuel Figueira, Alberto, Filevich, Andrej Filipčič (Stefan, Inst., Ljubljana &amp, Nova Gorica, U. )., Octavian Fratu (Bucharest, Martín Miguel Freire (IFIR, Rosario &amp, Rosario, U. )., Toshihiro Fujii (Chicago, U., Beatriz García, (Natl. Tech. U., San, Rafael), Diego Garcia-Gamez (Orsay, Diego Garcia-Pinto (Madrid, U. )., Florian Gate (SUBATECH, Hartmut Gemmeke (KIT, Karlsruhe, IPE), Alexandru Gherghel-Lascu (Bucharest, Piera Luisa Ghia (Paris, U., Ugo Giaccari (Rio de Janeiro Federal, U. )., INFN, Marco Giammarchi (Milan U., Maria, Giller, Dariusz Głas (Lodz, U. )., Christian Glaser (Aachen, Henry Glass (Fermilab), Geraldina, Golup, Mariano Gómez Berisso (Centro Atomico Bariloche &amp, Primo F Gómez Vitale (Pierre Auger, Observ. )., Nicolás, González, Ben Gookin (Colorado State, U. )., Jacob Gordon (Ohio State, U. )., Alessio Gorgi (IFSI, Peter Gorham (Hawaii, U. )., Philippe Gouffon (Sao Paulo, U. )., Nathan Griffith (Ohio State, U. )., Aurelio Grillo (Gran Sasso), Trent D Grubb (Adelaide, U. )., INFN, Fausto Guarino (Naples U., Germano Guedes (UEFS, Feira de Santana), Matías Rolf Hampel, Patricia Hansen (La Plata, U. )., Diego Harari (Centro Atomico Bariloche &amp, Thomas A Harrison (Adelaide, U. )., Sebastian Hartmann (Aachen, John Harton (Colorado State, U. )., Andreas Haungs (KIT, Thomas Hebbeker (Aachen, Dieter Heck (KIT, Philipp Heimann (Siegen, U. )., Alexander, E Herve (KIT, Gary C Hill (Adelaide, U. )., Carlos Hojvat (Fermilab), Nicholas Hollon (Chicago, U., Ewa Holt (KIT, Piotr Homola (Wuppertal, U. )., Jörg Hörandel (Nijmegen, U., Pavel Horvath (Palacky, U. )., Miroslav Hrabovský (Prague, Ins, t. Phys. &amp, Palacky U. )., Daniel Huber (KIT, Tim Huege (KIT, INFN, Antonio Insolia (Catania U., Paula Gina Isar (Bucharest, Ingolf Jandt (Wuppertal, U. )., Stefan Jansen (Nijmegen, U., Cecilia Jarne (La Plata, U. )., Jeffrey, A Johnsen (Colorado School of Mines), Mariela, Josebachuili, Alex Kääpä (Wuppertal, U. )., Olga Kambeitz (KIT, Karl Heinz Kampert (Wuppertal, U. )., Peter Kasper (Fermilab), Igor Katkov (KIT, Bianca Keilhauer (KIT, Ernesto Kemp (Campinas State, U. )., Roger Kieckhafer (Michigan, Tech. U. )., Hans Klages (KIT, Matthias Kleifges (KIT, Jonny Kleinfeller (Pierre Auger, Observ. )., Raphael Krause (Aachen, Nicole Krohm (Wuppertal, U. )., Daniel Kuempel (Aachen, Gasper Kukec Mezek (Nova Gorica, U. )., Norbert Kunka (KIT, Alaa Metwaly Kuotb Awad (KIT, Danielle LaHurd (Case Western Reserve, U. )., Luca Latronico (IFSI, Robert Lauer (New Mexico, U. )., Markus Lauscher (Aachen, Pascal Lautridou (SUBATECH, Sandra Le Coz, Didier Lebrun (LPSC, Paul Lebrun (Fermilab), Marcelo Augusto Leigui de Oliveira (ABC Federal, U. )., Antoine Letessier-Selvon (Paris, U., Isabelle Lhenry-Yvon (Orsay, Katrin Link (KIT, Luis Lopes (LIP, Rebeca López (Puebla, U., Ins, t. Fis. )., Aida López Casado (Santiago de Compostela, U. )., Karim Louedec (LPSC, Agustin, Lucero, Max Malacari (Adelaide, U. )., INFN, Manuela Mallamaci (Milan U., Jennifer Maller (SUBATECH, Dusan Mandat (Prague, Paul Mantsch (Fermilab), Analisa Mariazzi (La Plata, U. )., Vincent Marin (SUBATECH, CAFPE, Ioana Mariş (Granada U., Giovanni, Marsella, INFN, Daniele Martello (Salento U., Humberto Martinez (CINVESTAV, Oscar Martínez Bravo (Puebla, U., Diane Martraire (Orsay, Jimmy Masías Meza (Buenos Aires, U. )., Hermann-Josef Mathes (KIT, Sebastian Mathys (Wuppertal, U. )., James Matthews (Louisiana State, U. )., John Matthews (New Mexico, U. )., Giorgio Matthiae (Rome, U., Daniela Maurizio (Rio de Janeiro, CBPF), Eric Mayotte (Colorado School of Mines), Peter Mazur (Fermilab), Carlos Medina (Colorado School of Mines), Gustavo Medina-Tanco (Mexico, U. )., Rebecca Meissner (Aachen, Victor Mello (Rio de Janeiro Federal, U. )., Diego, Melo, Alexander Menshikov (KIT, Stefano Messina (Groningen, Maria Isabel Micheletti (IFIR, Lukas Middendorf (Aachen, Ignacio A Minaya (Madrid, U. )., INFN, Lino Miramonti (Milan U., Bogdan Mitrica (Bucharest, CAFPE, Laura Molina-Bueno (Granada U., Silvia Mollerach (Centro Atomico Bariloche &amp, François Montanet (LPSC, Carlo Morello (IFSI, Miguel Mostafá (Penn State, U. )., Celio A Moura (ABC Federal, U. )., Marcio Aparecido Muller (Campinas State, U. )., Gero Müller (Aachen, Sarah Müller (KIT, CAFPE, Sergio Navas (Granada U., Petr Necesal (Prague, Lukas Nellen (Mexico, U. )., Anna Nelles (Nijmegen, U., Jens Neuser (Wuppertal, U. )., Phong H Nguyen (Adelaide, U. )., Mihai Niculescu-Oglinzanu (Bucharest, Marcus Niechciol (Siegen, U. )., Lukas Niemietz (Wuppertal, U. )., Tim Niggemann (Aachen, Dave Nitz (Michigan, Tech. U. )., Dalibor, Nosek, Vladimir Novotny (Charles, U. )., Lyberis Nožka (Palacky, U. )., Luis Núñez (Cantabria, U., Livingstone Ochilo (Siegen, U. )., Foteini Oikonomou (Penn State, U. )., Angela Olinto (Chicago, U., Noelia Pacheco (Alcala de Henares, U. )., Daniel Pakk Selmi-Dei (Campinas State, U. )., Miroslav Palatka (Prague, Juan Pallotta (LIDAR CITEFA), Philipp Papenbreer (Wuppertal, U. )., Gonzalo Parente (Santiago de Compostela, U. )., Alejandra Parra (Puebla, U., Thomas Paul (Lehman, Coll. &amp, Northeastern U. )., Miroslav Pech (Prague, Jan Pękala (Cracow, Rodrigo Pelayo (Ulisted, MX), Iuri Pepe (Bahia, U. )., INFN, Lorenzo Perrone (Salento U., Emily Petermann (Nebraska, U. )., Christine Peters (Aachen, INFN, Sergio Petrera (L'Aquila U., Yevgeniy Petrov (Colorado State, U. )., Jamyang Phuntsok (Penn State, U. )., Ricardo Piegaia (Buenos Aires, U. )., Tanguy Pierog (KIT, Pablo Pieroni (Buenos Aires, U. )., Mário Pimenta (LIP, INFN, Valerio Pirronello (Catania U., Manuel, Platino, Matthias Plum (Aachen, Alessio Porcelli (KIT, Czeslaw Porowski (Cracow, Raul Ribeiro Prado (Sao Paulo, U., Paolo Privitera (Chicago, U., Michael Prouza (Prague, Eduardo, J Quel (LIDAR CITEFA), Sven Querchfeld (Wuppertal, U. )., Sean Quinn (Case Western Reserve, U. )., Julian Rautenberg (Wuppertal, U. )., Olivier Ravel (SUBATECH, Diego, Ravignani, Darius Reinert (Aachen, Benoît Revenu (SUBATECH, Jan Ridky (Prague, Markus Risse (Siegen, U. )., Pablo Ristori (LIDAR CITEFA), INFN, Vincenzo Rizi (L'Aquila U., Washington Rodrigues de Carvalho (Santiago de Compostela, U. )., Jorge Rubén Rodriguez Rojo (Pierre Auger, Observ. )., Maria Dolores Rodríguez-Frías (Alcala de Henares, U. )., Dmytro Rogozin (KIT, Jaime Rosado (Madrid, U. )., Markus Roth (KIT, Esteban Roulet (Centro Atomico Bariloche &amp, Adrian Rovero (Buenos Aires, Steven J Saffi (Adelaide, U. )., Alexandra Saftoiu (Bucharest, Humberto Salazar (Puebla, U., Ahmed Saleh (Nova Gorica, U. )., Francisco Salesa Greus (Penn State, U. )., Gaetano Salina (Rome, U., Jose Sanabria Gomez (Cantabria, U., Federico, Sánchez, CAFPE, Patricia Sanchez-Lucas (Granada U., Edivaldo Moura Santos (Sao Paulo, U. )., Eva Santos (Campinas State, U. )., Fred Sarazin (Colorado School of Mines), Biswaijt Sarkar (Wuppertal, U. )., Raul Sarmento (LIP, Christian Sarmiento-Cano (Cantabria, U., Ricardo, Sato, Carlos Scarso (Pierre Auger, Observ. )., Markus Schauer (Wuppertal, U. )., INFN, Viviana Scherini (Salento U., Harald, Schieler, David Schmidt (KIT, Olaf Scholten (Groningen, Harm Schoorlemmer (Hawaii, U. )., Petr Schovánek (Prague, Frank, G Schröder, Alexander Schulz (KIT, Johannes Schulz (Nijmegen, U., Johannes Schumacher (Aachen, Sergio Sciutto (La Plata, U. )., Alberto Segreto (IASF, Palermo), Mariangela Settimo (Paris, U., Amir Shadkam (Louisiana State, U. )., Ronald, C Shellard (Rio de Janeiro, Guenter Sigl (Hamburg, U., Octavian Sima (Bucharest, U. )., Andrzej Śmiałkowski (Lodz, U. )., Radomir Šmída (KIT, Gregory Snow (Nebraska, U. )., Paul Sommers (Penn State, U. )., Sebastian Sonntag (Siegen, U. )., J Sorokin (Adelaide, U. )., Ruben Squartini (Pierre Auger, Observ. )., Yogendra N Srivastava (Northeastern, U. )., Denis Stanca (Bucharest, Samo Stanič (Nova Gorica, U. )., James Stapleton (Ohio State, U. )., Jaroslaw Stasielak (Cracow, Maurice Stephan (Aachen, Anne Stutz (LPSC, Federico Suarez, (U. Tech. Natl., Mauricio Suarez Durán (Cantabria, U., Tiina Suomijärvi (Orsay, A Daniel Supanitsky (Buenos Aires, Michael Sutherland (Ohio State, U. )., John Swain (Northeastern, U. )., Zbigniew Szadkowski (Lodz, U. )., Oscar Alejandro Taborda (Centro Atomico Bariloche &amp, Alex, Tapia, Andreas Tepe (Siegen, U. )., Vanessa Menezes Theodoro (Campinas State, U. )., Omar Tibolla (Unlisted, Charles Timmermans (Nijmegen, U., Carlos, J Todero Peixoto, Gabriel Toma (Bucharest, Lenka Tomankova (KIT, Bernardo Tomé (LIP, INFN, Aurelio Tonachini (Turin U., Guillermo Torralba Elipe (Santiago de Compostela, U. )., Diego Torres Machado (Rio de Janeiro Federal, U. )., Petr Travnicek (Prague, Marta Trini (Nova Gorica, U. )., Ralf Ulrich (KIT, Michael Unger (KIT, New York, U. )., Martin Urban (Aachen, Jose F Valdés Galicia (Mexico, U. )., Ines Valiño (Santiago de Compostela, U. )., INFN, Laura Valore (Naples U., Guus van Aar (Nijmegen, U., Patrick van Bodegom (Adelaide, U. )., M van den Berg (Groningen, Ad, Sjoert van Velzen (Nijmegen, U., Arjen van Vliet (Hamburg, U., Enrique Varela (Puebla, U., Bernardo Vargas Cárdenas (Mexico, U. )., Gary Varner (Hawaii, U. )., Rafael Vasquez (Rio de Janeiro Federal, U. )., Jose R Vázquez (Madrid, U. )., Ricardo Vázquez (Santiago de Compostela, U. )., Darko Veberič (KIT, Valerio Verzi (Rome, U., Jakub Vicha (Prague, Mariela, Videla, Luis Villaseñor (IFM-UMSNH, Brian Vlcek (Alcala de Henares, U. )., Serguei Vorobiov (Nova Gorica, U. )., Hernan Wahlberg (La Plata, U. )., Oscar Wainberg, (U. Tech. Natl., David Walz (Aachen, Alan, Watson, Marc Weber (KIT, Klaus Weidenhaupt (Aachen, Andreas Weindl (KIT, Christoph Welling (Aachen, Felix Werner (KIT, Allan Widom (Northeastern, U. )., Lawrence Wiencke (Colorado School of Mines), Henryk Wilczyński (Cracow, Tobias, Winchen, David Wittkowski (Wuppertal, U. )., Brian, Wundheiler, Sarka Wykes (Nijmegen, U., Lili Yang (Nova Gorica, U. )., Tolga Yapici (Michigan, Tech. U. )., Alexey Yushkov (Siegen, U. )., Enrique Zas (Santiago de Compostela, U. )., Danilo, Zavrtanik, Marko Zavrtanik (Stefan, Inst., Arnulfo Zepeda (CINVESTAV, Benedikt Zimmermann (KIT, Michael Ziolkowski (Siegen, U. )., INFN, Francesca Zuccarello (Catania U., Catania), ), Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Al Samarai, I., Albuquerque, I. F. M., Allekotte, I., Allison, P., Almela, A., Alvarez Castillo, J., Alvarez Muñiz, J., Alves Batista, R., Ambrosio, M., Aminaei, A., Anastasi, G. A., Anchordoqui, L., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Awal, N., Badescu, A. M., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Blaess, S. G., Blanco, A., Blanco, M., Blazek, J., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Brogueira, P., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero Mora, K. S., Caccianiga, B., Caccianiga, L., Candusso, M., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Cilmo, M., Clay, R. W., Cocciolo, G., Colalillo, Roberta, Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Cordier, A., Coutu, S., Covault, C. E., Cronin, J., Dallier, R., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., De Almeida, R. M., De Jong, S. J., De Mauro, G., De Mello Neto, J. R. T., De Mitri, I., De Oliveira, J., De Souza, V., Del Peral, L., Deligny, O., Dhital, N., Di Giulio, C., Di Matteo, A., Diaz, J. C., Díaz Castro, M. L., Diogo, F., Dobrigkeit, C., Docters, W., D'Olivo, J. C., Dorofeev, A., Dorosti Hasankiadeh, Q., Dos Anjos, R. C., Dova, M. T., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., García, B., Garcia Gamez, D., Garcia Pinto, D., Gate, F., Gemmeke, H., Gherghel Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Gómez Berisso, M., Gómez Vitale, P. F., González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Griffith, N., Grillo, A. F., Grubb, T. D., Guarino, Fausto, Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Hartmann, S., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Hollon, N., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huber, D., Huege, T., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Jarne, C., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Kukec Mezek, G., Kunka, N., Kuotb Awad, A. W., Lahurd, D., Latronico, L., Lauer, R., Lauscher, M., Lautridou, P., Le Coz, S., Lebrun, D., Lebrun, P., Leigui De Oliveira, M. A., Letessier Selvon, A., Lhenry Yvon, I., Link, K., Lopes, L., López, R., López Casado, A., Louedec, K., Lucero, A., Malacari, M., Mallamaci, M., Maller, J., Mandat, D., Mantsch, P., Mariazzi, A. G., Marin, V., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Martínez Bravo, O., Martraire, D., Masías Meza, J. J., Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mayotte, E., Mazur, P. O., Medina, C., Medina Tanco, G., Meissner, R., Mello, V. B. B., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Molina Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Moura, C. A., Muller, M. A., Müller, G., Müller, S., Navas, S., Necesal, P., Nellen, L., Nelles, A., Neuser, J., Nguyen, P. H., Niculescu Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Pacheco, N., Pakk Selmi Dei, D., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pokala, J., Pelayo, R., Pepe, I. M., Perrone, L., Petermann, E., Peters, C., Petrera, S., Petrov, Y., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porcelli, A., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Rautenberg, J., Ravel, O., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., Rodrigues De Carvalho, W., Rodriguez Rojo, J., Rodríguez Frías, M. D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Salesa Greus, F., Salina, G., Sanabria Gomez, J. D., Sánchez, F., Sanchez Lucas, P., Santos, E., Santos, E. M., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento Cano, C., Sato, R., Scarso, C., Schauer, M., Scherini, V., Schieler, H., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Srivastava, Y. N., Stanca, D., Stanič, S., Stapleton, J., Stasielak, J., Stephan, M., Stutz, A., Suarez, F., Suarez Durán, M., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Timmermans, C., Todero Peixoto, C. J., Toma, G., Tomankova, L., Tomé, B., Tonachini, A., Torralba Elipe, G., Torres Machado, D., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Valdés Galicia, J. F., Valiño, I., Valore, Laura, Van Aar, G., Van Bodegom, P., Van Den Berg, A. M., Van Velzen, S., Van Vliet, A., Varela, E., Vargas Cárdenas, B., Varner, G., Vasquez, R., Vázquez, J. R., Vázquez, R. A., Veberič, D., Verzi, V., Vicha, J., Videla, M., Villaseñor, L., Vlcek, B., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weidenhaupt, K., Weindl, A., Welling, C., Werner, F., Widom, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yapici, T., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zuccarello, F., Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS), Unité Scientifique de la Station de Nançay (USN), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de Physique Nucléaire d'Orsay (IPNO), Pierre AUGER, ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), ANR-10-LABX-0063,ILP,Institute Lagrange of Paris(2010), European Project: 328826,EC:FP7:PEOPLE,FP7-PEOPLE-2012-IEF,AUGER2FUTURE(2013), Elementary Particle Physics, Physics, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Observatoire des Sciences de l'Univers en région Centre (OSUC), Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Ahn, E. . j., Albuquerque, I. . f. . m., Anastasi, G. . a., Badescu, A. . m., Beatty, J. . j., Becker, K. . h., Bellido, J. . a., Bertaina, M. . e., Biermann, P. . l., Blaess, S. . g., Bleve, Carla, Caballero Mora, K. . s., Chavez, A. . g., Chinellato, J. . a., Clay, R. . w., Colalillo, R., Coluccia, MARIA RITA, Cooper, M. . j., Covault, C. . e., Dawson, B. . r., de Almeida, R. . m., de Jong, S. . j., de Mello Neto, J. . r. . t., DE MITRI, Ivan, de Oliveira, J., de Souza, V., del Peral, L., Diaz, J. . c., Díaz Castro, M. . l., D’Olivo, J. . c., dos Anjos, R. . c., Dova, M. . t., Escobar, C. . o., Fauth, A. . c., Ferguson, A. . p., Figueira, J. . m., Freire, M. . m., Ghia, P. . l., Gómez Vitale, P. . f., Grillo, A. . f., Grubb, T. . d., Guarino, F., Guedes, G. . p., Hampel, M. . r., Harrison, T. . a., Harton, J. . l., Herve, A. . e., Hill, G. . c., Hörandel, J. . r., Isar, P. . g., Johnsen, J. . a., Kampert, K. . h., Kieckhafer, R. . m., Klages, H. . o., Kuotb Awad, A. . w., Leigui de Oliveira, M. . a., Mariazzi, A. . g., Mariş, I. . c., Marsella, Giovanni, Martello, Daniele, Masías Meza, J. . j., Mathes, H. . j., Matthews, J. . a. . j., Mazur, P. . o., Mello, V. . b. . b., Micheletti, M. . i., Minaya, I. . a., Moura, C. . a., Muller, M. . a., Nguyen, P. . h., Núñez, L. . a., Pȩkala, J., Pepe, I. . m., Perrone, Lorenzo, Prado, R. . r., Quel, E. . j., Rodrigues de Carvalho, W., Rodríguez Frías, M. . d., Rovero, A. . c., Saffi, S. . j., Sanabria Gomez, J. . d., Santos, E. . m., Schröder, F. . g., Sciutto, S. . j., Shellard, R. . c., Snow, G. . r., Srivastava, Y. . n., Supanitsky, A. . d., Sutherland, M. . s., Taborda, O. . a., Theodoro, V. . m., Todero Peixoto, C. . j., Valdés Galicia, J. . f., Valore, L., van Aar, G., van Bodegom, P., van den Berg, A. . m., van Velzen, S., van Vliet, A., Vázquez, J. . r., Vázquez, R. . a., Watson, A. . a., Research unit Astroparticle Physics, and Research unit Nuclear & Hadron Physics
Subjects: Cosmic ray showers, Astronomy, Ciencias Físicas, ULTRA HIGH ENERGY COSMIC RAYS, Astrophysics, 01 natural sciences, purl.org/becyt/ford/1 [https], ultra-high energy cosmic rays, extensive air showers, radio energy estimation, CODALEMA, Observatory, Radio detection, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Detector, Astrophysics::Instrumentation and Methods for Astrophysics, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Física nuclear, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, CIENCIAS NATURALES Y EXACTAS, EXTENSIVE AIR-SHOWERS, MONTE-CARLO SIMULATIONS, EMISSION, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Nuclear and High Energy Physics, EXTENSIVE AIR-SHOWERS, MONTE-CARLO SIMULATIONS, EMISSION, CODALEMA, COREAS, LOFAR, AIR SHOWERS, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Cosmic ray, Astrophysics::Cosmology and Extragalactic Astrophysics, EXTENSIVE AIR-SHOWERS, RADIO EMISSION, 0103 physical sciences, High Energy Physics, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Cosmic rays, Pierre Auger Observatory, 010308 nuclear & particles physics, Radiant energy, Física, LOFAR, purl.org/becyt/ford/1.3 [https], ASTROFÍSICA, Computational physics, Astronomía, COREAS, Earth's magnetic field, Air shower, Experimental High Energy Physics, EMISSION, MONTE-CARLO SIMULATIONS
Abstract: The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30-80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy - corrected for geometrical effects - is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal., La lista completa de autores que integran el documento puede consultarse en el archivo, Instituto de Física La Plata
Published: 2016
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18. Ultrahigh-energy neutrino follow-up of gravitational wave events GW150914 and GW151226 with the Pierre Auger Observatory

Author: F. Canfora, P. Heimann, Q. Luce, P. Abreu, R.J. Barreira Luz, G. A. Anastasi, E. Kemp, D. Ravignani, Serguei Vorobiov, D. Mockler, Luis A. Anchordoqui, C. Aramo, John N. Matthews, R. M. Kieckhafer, O. A. Taborda, Johannes Schumacher, G. Matthiae, M. Platino, Antonio Bueno, M. Josebachuili, O. Wainberg, K. H. Becker, Gualberto Avila, B. Mitrica, Heino Falcke, E.M. Holt, Ingomar Allekotte, G. De Mauro, A. Fuster, Maria-Teresa Dova, M. R. Hampel, S. Petrera, G. S. Varner, Sarka Wykes, Octavian Fratu, Angela V. Olinto, R.C. dos Anjos, Julian Rautenberg, M. Palatka, C. Di Giulio, G. C. Hill, M. Mallamaci, S. J. De Jong, Jörg R. Hörandel, J. Vicha, Petr Travnicek, Trent D. Grubb, R. Squartini, Jeffrey A. Johnsen, Juan Manuel Figueira, Roberta Colalillo, A. G. Mariazzi, Ralph Engel, T. Paul, J. Ridky, M. Suarez Durán, J. Stasielak, S. Coutu, Ugo Giaccari, F. Montanet, S. Quinn, Günter Sigl, M. Trini, David Wittkowski, M. Urban, Norberto Fazzini, J. F. Valdés Galicia, I. De Mitri, L. Molina-Bueno, D. Melo, David Walz, G. Medina-Tanco, D. Pakk Selmi-Dei, R. Sato, J. R. T. de Mello Neto, M. Hrabovský, G. van Aar, Radomir Smida, A. C. Rovero, C. Bleve, Alexandru Balaceanu, Hernan Wahlberg, Andreas Weindl, M. Zavrtanik, H. Nožka, R. Gaior, Dieter Heck, Lourenco Lopes, A. Gorgi, A. Saleh, Vincenzo Rizi, Octavian Sima, M. A. Leigui de Oliveira, G. Müller, N. Kunka, H. Glass, M. Ambrosio, V. Scherini, G. Torralba Elipe, R. R. Prado, G. Kukec Mezek, L. Nellen, Alexandra Saftoiu, M. Schauer, D. Yelos, C. Porowski, Florian Gaté, M. Erdmann, A. van Vliet, Andreas Haungs, A. Coleman, M. Ziolkowski, O. Martínez Bravo, C. J. Todero Peixoto, C. Morello, Dusan Mandat, A. Parra, I. Lhenry-Yvon, M. E. Bertaina, V. de Souza, L. Valore, O. Kambeitz, H. Martinez, I. Naranjo, A. Menshikov, F. Suarez, Thomas Hebbeker, M. A. Muller, J. J. Beatty, N. Krohm, Andrej Dundovic, P. Ristori, Danielle LaHurd, Olivier Deligny, E. Mayotte, E. Varela, J.D. Sanabria Gomez, Petr Schovanek, Sergio Dasso, Tristan Sudholz, W. Rodrigues de Carvalho, Paul Sommers, A. Blanco, B. Sarkar, Lorenzo Caccianiga, V. M. Theodoro, A. Kääpä, P. H. Nguyen, A. Segreto, Silvia Mollerach, D. Garcia-Pinto, Christian Glaser, P. Gouffon, J. W. Cronin, Philipp Papenbreer, J. Espadanal, Peter L. Biermann, P. Stassi, Denise Boncioli, J. Rodriguez Rojo, R. Krause, J. A.J. Matthews, Xavier Bertou, J. D. Swain, P. van Bodegom, A. Kuotb Awad, V. Pirronello, A. G. Chavez, Alberto Daniel Supanitsky, Francesco Strafella, J. L. Harton, P. Lebrun, Julien Aublin, D. Nosek, Paolo Privitera, M. J. Cooper, S. G. Blaess, Jaime Alvarez-Muñiz, F. Sánchez, Alexandru Gherghel-Lascu, A. Aab, J. Biteau, H. Wilczyński, P. Billoir, Tanguy Pierog, Pedro Assis, A. Insolia, B. Tome, Ana Martina Botti, M. Kleifges, D. Zavrtanik, A. Cancio, A. Etchegoyen, Peter Mazur, A. Shadkam, Carlos Medina, Nataliia Borodai, Hermann-Josef Mathes, Enrique Zas, A. Di Matteo, I. Al Samarai, G. Marsella, L. Caramete, Marco Giammarchi, Markus Roth, H. Gemmeke, Dariusz Glas, Denis Stanca, T. Suomijärvi, D. Martello, Jose Chinellato, C. Peters, Michael Unger, B. Wundheiler, L. A. S. Pereira, Maria Giller, M. I. Micheletti, Peter Gorham, Charles Timmermans, Lukas Middendorf, Fernando Contreras, Gregory R Snow, L. Collica, I. Jandt, A. Letessier-Selvon, J. Hulsman, I. A. Minaya, B. Keilhauer, G. P. Guedes, Toshihiro Fujii, S. Jansen, Kai Daumiller, S. Müller, Lorenzo Cazon, Ralf Ulrich, Paul M. Mantsch, B. Vargas Cárdenas, André Schulz, J. Debatin, M. Gómez Berisso, R. C. Shellard, L. Perrone, Jiri Chudoba, G. Rodriguez Fernandez, D. Torres Machado, V. Verzi, J. Pallotta, David Schmidt, M. L. Díaz Castro, G. Farrar, S. J. Sciutto, Katrin Link, Maria Rita Coluccia, Carola Dobrigkeit, Juan Carlos D'Olivo, M. Plum, Hernán Asorey, E. J. Quel, Bruno Daniel, Foteini Oikonomou, I. C. Mariş, Luis A. Nunez, R. Piegaia, Marcus Niechciol, Esteban Roulet, P. L. Ghia, Mario Buscemi, Francesca Zuccarello, Paula Gina Isar, J. J. Masías Meza, Jeffrey Brack, Olaf Scholten, Humberto Ibarguen Salazar, Thomas Harrison, Jesús Peña-Rodríguez, D. Nitz, A. Dorofeev, Alan Watson, Mihai Niculescu-Oglinzanu, F. Salesa Greus, G. Cataldi, Igor Katkov, J. Alvarez Castillo, P. Pieroni, Jan Pękala, Harald Schieler, F. Diogo, A. Taboada, A. E. Herve, A. Yushkov, Marco Torri, F. Arqueros, R. M. de Almeida, L. R. Wiencke, L. Villaseñor, Peter Hansen, Miguel Mostafa, Martina Bohacova, A. Śmiałkowski, D. Reinert, L. Tomankova, L. Ochilo, J. Sorokin, Z. Zong, Diego Harari, I. Valiño, P.F. Gómez Vitale, F. Guarino, Peter Buchholz, A. López Casado, Zbigniew Szadkowski, Brian Fick, Samo Stanič, Nicusor Arsene, A. Tapia, Rodrigo Pelayo, Stijn Buitink, E. Santos, I.M. Brancus, A. Bridgeman, B. Gookin, R. Ramos-Pollan, S. Messina, S. Querchfeld, S. J. Saffi, V. Novotny, Rossella Caruso, A. Lucero, S. Mathys, Marco Aglietta, J. Neuser, L. Niemietz, E. M. Santos, M. Erfani, R. A. Vázquez, Gaia Silli, F. Sarazin, Arnulfo Zepeda, Marc Weber, F. G. Schröder, B. Revenu, Markus Lauscher, Benedikt Zimmermann, Rúben Conceição, J. R. Vázquez, F. Pedreira, P. Sanchez-Lucas, P. Kasper, J. Phuntsok, Raul Sarmento, M. M. Freire, Bruce R. Dawson, Tim Huege, Alina Mihaela Badescu, M. Prouza, Tim Niggemann, Miroslav Pech, Nicolás González, A. C. Fauth, Corinne Berat, Q. Hasankiadeh, Pavel Horvath, Carla Bonifazi, A. Filipcic, Jose A. Bellido, S. Sonntag, B. Andrada, Sofia Andringa, R. Cester, C. A. Sarmiento, I.D. Vergara Quispe, M. Risse, Jonathan Blazek, G. Parente, Carlos Hojvat, R. Legumina, D. Rogozin, J. de Oliveira, Alejandro Almela, Julian Kemp, Michael Schimp, Colin Baus, Karl-Heinz Kampert, Antonella Castellina, Thomas Bretz, Corbin Covault, Geraldina Golup, Alexander Grillo, Lino Miramonti, B. García, Tobias Winchen, R. López, Karen S. Caballero-Mora, Roger W Clay, Stefano D'Amico, Johannes Schulz, M. Pimenta, Florian Lukas Briechle, Mariangela Settimo, Max Malacari, Lili Yang, Piotr Homola, J. Kleinfeller, Daniel Kuempel, Carlos Escobar, Ivone F. M. Albuquerque, Ke Fang, Jan Ebr, H.O. Klages, Gaetano Salina, A.M. van den Berg, Darko Veberič, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Pierre Auger Collaboration, Research unit Astroparticle Physics, Aab, A., Abreu, P., Aglietta, M., Al Samarai, I., Albuquerque, I. . f. . m., Allekotte, I., Almela, A., Alvarez Castillo, J., Alvarez Muñiz, J., Ambrosio, M., Anastasi, G. . a., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. . m., Balaceanu, A., Barreira Luz, R. . j., Baus, C., Beatty, J. . j., Becker, K. . h., Bellido, J. . a., Berat, C., Bertaina, M. . e., Bertou, X., Biermann, P. . l., Billoir, P., Biteau, J., Blaess, S. . g., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. . m., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. . l., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero Mora, K. . s., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. . g., Chinellato, J. . a., Chudoba, J., Clay, R. . w., Colalillo, Roberta, Coleman, A., Collica, L., Coluccia, M. . r., Conceição, R., Contreras, F., Cooper, M. . j., Coutu, S., Covault, C. . e., Cronin, J., D’Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. . r., de Almeida, R. . m., de Jong, S. . j., De Mauro, G., de Mello Neto, J. . r. . t., De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Díaz Castro, M. . l., Diogo, F., Dobrigkeit, C., D’Olivo, J. . c., Dorofeev, A., dos Anjos, R. . c., Dova, M. . t., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. . o., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. . c., Fazzini, N., Fick, B., Figueira, J. . m., Filipčič, A., Fratu, O., Freire, M. . m., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia Pinto, D., Gaté, F., Gemmeke, H., Gherghel Lascu, A., Ghia, P. . l., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Gómez Berisso, M., Gómez Vitale, P. . f., González, N., Gookin, B., Gorgi, A., Gorham, P., Gouffon, P., Grillo, A. . f., Grubb, T. . d., Guarino, Fausto, Guedes, G. . p., Hampel, M. . r., Hansen, P., Harari, D., Harrison, T. . a., Harton, J. . l., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. . e., Hill, G. . c., Hojvat, C., Holt, E., Homola, P., Hörandel, J. . r., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. . g., Jandt, I., Jansen, S., Johnsen, J. . a., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. . h., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. . m., Klages, H. . o., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Kukec Mezek, G., Kunka, N., Kuotb Awad, A., Lahurd, D., Lauscher, M., Lebrun, P., Legumina, R., Leigui de Oliveira, M. . a., Letessier Selvon, A., Lhenry Yvon, I., Link, K., Lopes, L., López, R., López Casado, A., Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. . g., Mariş, I. . c., Marsella, G., Martello, D., Martinez, H., Martínez Bravo, O., Masías Meza, J. . j., Mathes, H. . j., Mathys, S., Matthews, J., Matthews, J. . a. . j., Matthiae, G., Mayotte, E., Mazur, P. . o., Medina, C., Medina Tanco, G., Melo, D., Menshikov, A., Messina, S., Micheletti, M. . i., Middendorf, L., Minaya, I. . a., Miramonti, L., Mitrica, B., Mockler, D., Molina Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, G., Muller, M. . a., Müller, S., Naranjo, I., Nellen, L., Neuser, J., Nguyen, P. . 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m., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento, C. . a., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. . g., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. . j., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. . c., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. . r., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Suarez Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. . d., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. . a., Tapia, A., Theodoro, V. . m., Timmermans, C., Todero Peixoto, C. . j., Tomankova, L., Tomé, B., Torralba Elipe, G., Torres Machado, D., Torri, M., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Valdés Galicia, J. . f., Valiño, I., Valore, Laura, van Aar, G., van Bodegom, P., van den Berg, A. . m., van Vliet, A., Varela, E., Vargas Cárdenas, B., Varner, G., Vázquez, J. . r., Vázquez, R. . a., Veberič, D., Vergara Quispe, I. . d., Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. . a., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., Zuccarello, F., Bleve, Carla, Colalillo, R., Coluccia, MARIA RITA, D'Amico, Stefano, DE MITRI, Ivan, Guarino, F., Marsella, Giovanni, Martello, Daniele, Perrone, Lorenzo, Strafella, Francesco, Valore, L., Elementary Particle Physics, and Physics
Subjects: [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Astronomy, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics, magnetic fields, 7. Clean energy, 01 natural sciences, Ultrahigh-energy neutrino, gravitational waves, ultra-high energy cosmic rays, Observatory, 0103 physical sciences, GW151226, binary systems, High Energy Physics, 010303 astronomy & astrophysics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), gravitational wave, Ciencias Exactas, Pierre Auger Observatory, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), GAMMA-RAY BURSTS, 010308 nuclear & particles physics, Gravitational wave, Física, neutrinos, ASTROFÍSICA, black holes, LIGO, Black hole, 13. Climate action, Experimental High Energy Physics, Física nuclear, High Energy Physics::Experiment, Neutrino, Gamma-ray burst, Astrophysics - High Energy Astrophysical Phenomena
Abstract: On September 14, 2015 the Advanced LIGO detectors observed their first gravitational wave (GW) transient GW150914. This was followed by a second GW event observed on December 26, 2015. Both events were inferred to have arisen from the merger of black holes in binary systems. Such a system may emit neutrinos if there are magnetic fields and disk debris remaining from the formation of the two black holes. With the surface detector array of the Pierre Auger Observatory we can search for neutrinos with energy Eν above 100 PeV from pointlike sources across the sky with equatorial declination from about -65° to +60°, and, in particular, from a fraction of the 90% confidence-level inferred positions in the sky of GW150914 and GW151226. A targeted search for highly inclined extensive air showers, produced either by interactions of downward-going neutrinos of all flavors in the atmosphere or by the decays of tau leptons originating from tau-neutrino interactions in the Earth's crust (Earth-skimming neutrinos), yielded no candidates in the Auger data collected within ±500 s around or 1 day after the coordinated universal time (UTC) of GW150914 and GW151226, as well as in the same search periods relative to the UTC time of the GW candidate event LVT151012. From the nonobservation we constrain the amount of energy radiated in ultrahigh-energy neutrinos from such remarkable events., La lista completa de autores que integran el documento puede consultarse en el archivo., Facultad de Ciencias Exactas, Instituto de Física La Plata
Published: 2016
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19. Measurement of the radiation energy in the radio signal of extensive air showers as a universal estimator of cosmic-ray energy

Author: Alaa Kuotb Awad, Benoît Revenu, James Matthews, Alexandra Saftoiu, Alberto Filevich, Peter Hansen, Ivan De Mitri, I. Lhenry-Yvon, John Matthews, Peter Buchholz, Philipp Papenbreer, Petr Travnicek, H. Wahlberg, A. Nelles, R. Piegaia, I.M. Brancus, Alan Coleman, T. Hebbeker, Trent D. Grubb, D. Huber, Marco Aglietta, Eun-Joo Ahn, S. Vorobiov, K. Weidenhaupt, E.M. Holt, B. Wundheiler, A. Saleh, A. Parra, R. J. Lauer, Juan Manuel Figueira, S. Jansen, Bruno Daniel, Maria-Teresa Dova, Foteini Oikonomou, M. R. Hampel, Peter Mazur, J. Sorokin, Marcelo Augusto Leigui de Oliveira, Sarka Wykes, R. Meissner, Octavian Fratu, G. Parente, M. Trini, Roberta Colalillo, O. Wainberg, C. Bleve, P. Pieroni, S. Müller, Vincenzo Rizi, Nicusor Arsene, Julian Rautenberg, V. B. B. Mello, K. H. Becker, A. G. Mariazzi, Eric Mayotte, Jeffrey A. Johnsen, Sven Querchfeld, L. Perrone, R. C. Shellard, W. Docters, Carlos Hojvat, Ernesto Kemp, Xavier Bertou, Luis del Peral, Ugo Giaccari, Henryk Wilczyński, J. J. Beatty, Norbert Kunka, D. Nitz, Silvia Mollerach, D. Lebrun, S. Quinn, Sjoert van Velzen, Primo F. Gómez Vitale, R. Sato, S. Coutu, Norberto Fazzini, Antonio Bueno, Antonio Insolia, M. Josebachuili, Gualberto Avila, Ingomar Allekotte, G. Matthiae, Angela V. Olinto, O. Kambeitz, M. Ambrosio, Eva Santos, R. Krause, Jose Sanabria Gomez, M. Zavrtanik, Fred Sarazin, Lukas Nellen, B. Caccianiga, Julien Aublin, A. Shadkam, Amin Aminaei, Rafael Alves Batista, Jakub Vicha, Pedro Assis, Radomir Smida, Diego Harari, B. Gookin, P. H. Nguyen, Alberto Etchegoyen, Darius Reinert, Lorenzo Caccianiga, V. M. Theodoro, Tobias Winchen, D. Martello, Karen S. Caballero-Mora, Michael Unger, D. Melo, Luca Latronico, Guenter Sigl, D. Garcia-Pinto, Alessio Gorgi, Paul Sommers, A. Blanco, M. J. Cooper, S. Stanič, Carlos Medina, Tanguy Pierog, Mariano Gómez Berisso, D. Rogozin, Alejandro Almela, E. M. Santos, P. Heimann, Florian Gaté, J. R. Vázquez, Carla Bonifazi, Bernardo Vargas Cárdenas, A. C. Rovero, B. Tome, Marco Giammarchi, D. Garcia-Gamez, J. W. H. Gordon, Jose A. Bellido, L. Niemietz, S. Hartmann, Martin Erdmann, Jan Pękala, Hans Klages, A. Chiavassa, P. Sanchez-Lucas, Vitor de Souza, Bruce R. Dawson, Tim Huege, Carola Dobrigkeit, M. Plum, P. Abreu, Miguel Mostafá, C. Porowski, S. Sonntag, Markus Risse, Christian Sarmiento-Cano, B. Vlcek, Dariusz Glas, Diego Ravignani, O. A. Taborda, M. Settimo, M. Blanco, Mário Pimenta, Gregory R Snow, Pablo Ristori, P. H. Kasper, Gaetano Salina, Maria Rita Coluccia, Yogendra N. Srivastava, Alan Watson, Glennys R. Farrar, C. Jarne, A. Śmiałkowski, Andreas Weindl, Jaime Rosado, R. Cester, Alina Mihaela Badescu, F. Sánchez, N. Awal, Beatriz García, Jeffrey Brack, Olaf Scholten, Humberto Ibarguen Salazar, J. W. Cronin, Harald Schieler, Antoine Letessier-Selvon, C. Aramo, B. Mitrica, Heino Falcke, Nicolás González, Mihai Niculescu-Oglinzanu, Jonny Kleinfeller, K. Louedec, Arnulfo Zepeda, Armando di Matteo, G. Cocciolo, Roger W Clay, R. López, M. Mallamaci, F. G. Schröder, Mary Lucia Díaz Castro, Denise Boncioli, Jiri Chudoba, P. Lebrun, Alex Kääpä, Alberto Segreto, G. Toma, Benedikt Zimmermann, Rúben Conceição, R. Vasquez, Dusan Mandat, Colin Baus, Darko Veberič, D. Martraire, Oscar Martínez Bravo, Miroslav Hrabovský, T. Yapici, Alexey Yushkov, G. A. Anastasi, Pascal Lautridou, W. R. Carvalho, Dieter Heck, Martin Urban, G. S. Varner, Nataliia Borodai, Toshihiro Fujii, A. Menshikov, C. Morello, Jaroslaw Stasielak, Luis A. Anchordoqui, Markus Roth, N. Griffith, S. G. Blaess, Niraj Dhital, Jörg R. Hörandel, Thomas Harrison, Jaime de Oliveira, I. Valiño, H. Blümer, Max Malacari, Lili Yang, Laura Valore, L. Lopes, Lukas Middendorf, Corinne Berat, Piotr Homola, Lawrence Wiencke, Fausto Guarino, A. Filipčič, A. Aab, Johannes Schumacher, J. Neuser, Alex Tapia, Christine Peters, Ad M. van den Berg, Juan Pallotta, S. Le Coz, Jaime Alvarez-Muñiz, Alexandru Gherghel-Lascu, Mauricio Suaréz Durán, Petr Schovanek, L. Caramete, Rita dos Anjos, João de Mello Neto, H. Gemmeke, Peter L. Biermann, Sergio Sciutto, L. Ochilo, T. Suomijärvi, Karl-Heinz Kampert, Antonella Castellina, M. I. Micheletti, Federico Suarez, A. Schulz, J. Stapleton, L. Molina-Bueno, Q. Hasankiadeh, L. Tomankova, F. Arqueros, P. Necesal, Daniel Pakk Selmi-Dei, Imen Al Samarai, Martina Bohacova, David Walz, Johannes Schulz, Ruben Squartini, Paolo Privitera, F. Diogo, Juan Carlos D'Olivo, Patrick van Bodegom, Esteban Roulet, Patrick Allison, I. A. Minaya, Hernán Asorey, John Swain, Thomas Bretz, R.R. Prado, Harm Schoorlemmer, John L. Harton, T. Paul, A. Lucero, Jan Ridky, Marc Weber, F. Werner, Katrin Link, Denis Stanca, Guus van Aar, D. Maurizio, A. P. Ferguson, Corbin Covault, Y. Petrov, Geraldina Golup, Alexander Grillo, Zbigniew Szadkowski, Alessio Porcelli, J. C. Diaz, Rodrigo Pelayo, Stijn Buitink, N. Hollon, Olivier Ravel, C. A. Moura, Jose F. Valdés Galicia, Brian Fick, Lino Miramonti, Luis A. Nunez, M. Buscemi, C. Scarso, C. Welling, Marcus Niechciol, V. Novotny, Arjen van Vliet, A. Stutz, E. Varela, Rossella Caruso, S. Mathys, M. Erfani, Eduardo Quel, Henry Glass, Michael Sutherland, Francisco Salesa Greus, Guillermo Torralba Elipe, Piera Luisa Ghia, I. Jandt, Octavian Sima, Manuel Platino, M. D. Rodríguez-Frías, M. Schauer, N. Pacheco, Tim Niggemann, D. Nosek, Jan Ebr, V. Scherini, Jimmy Masías Meza, M. Candusso, Peter Gorham, Valerio Pirronello, Charles Timmermans, L. Collica, Sergio Petrera, Paul M. Mantsch, Miroslav Palatka, Jesus Alvarez Castillo, J. Blazek, Gustavo Medina-Tanco, Anderson Fauth, Vincent Marin, Rogerio M. de Almeida, M. E. Bertaina, B. Sarkar, Christian Glaser, S. Messina, Claudio Di Giulio, L. Nožka, J. Espadanal, Diego Torres Machado, Paula Gina Isar, Pedro Brogueira, G. Cataldi, Sergio Dasso, Martín Miguel Freire, P. Billoir, Aida López Casado, Carlos J. Todero Peixoto, G. Marsella, Daniel Kuempel, Carlos Escobar, R.M. Kieckhafer, Iuri Muniz Pepe, Maria Giller, Hermann-Josef Mathes, A. Cordier, Ivone F. M. Albuquerque, Ke Fang, Gašper Kukec Mezek, I. Katkov, Richard Dallier, Francesca Zuccarello, Kai Daumiller, Maurice Stephan, M. Ziolkowski, A. Tonachini, A.E. Herve, F. Montanet, J. Maller, V. Verzi, David Schmidt, S. Sánchez Navas, Jose Chinellato, Lorenzo Cazon, Ioana Codrina Maris, Ricardo Vázquez, Giuseppe De Mauro, G. C. Hill, Ralph Engel, Andreas Haungs, M. Videla, A. Daniel Supanitsky, Matthias Kleifges, H. Martinez, David Wittkowski, Germano Guedes, Danielle LaHurd, Olivier Deligny, Marcio Aparecido Muller, A. Dorofeev, L. Villaseñor, Marco Cilmo, Jorge Rubén Rodriguez Rojo, A. Bridgeman, E. Petermann, S. J. Saffi, Markus Lauscher, J. Phuntsok, Raul Sarmento, M. Prouza, Bianca Keilhauer, A. G. Chavez, Enrique Zas, Sijbrand J. de Jong, Fernando Contreras, N. Krohm, Miroslav Pech, R. Ulrich, Pavel Horvath, P. Gouffon, Allan Widom, Danilo Zavrtanik, Gero Müller, Sofia Andringa, A. Tepe, Research unit Nuclear & Hadron Physics, Research unit Astroparticle Physics, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Unité Scientifique de la Station de Nançay (USN), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Institut de Physique Nucléaire d'Orsay (IPNO), Pierre Auger Collaboration, ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), European Project: 328826,EC:FP7:PEOPLE,FP7-PEOPLE-2012-IEF,AUGER2FUTURE(2013), European Project: 246806,EC:FP7:PEOPLE,FP7-PEOPLE-2009-IRSES,EPLANET(2011), Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Al Samarai, I., Albuquerque, I. F. M., Allekotte, I., Allison, P., Almela, A., Alvarez Castillo, J., Alvarez Muñiz, J., Alves Batista, R., Ambrosio, M., Aminaei, A., Anastasi, G. A., Anchordoqui, L., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Awal, N., Badescu, A. M., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Blaess, S. G., Blanco, A., Blanco, M., Blazek, J., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Brogueira, P., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero Mora, K. S., Caccianiga, B., Caccianiga, L., Candusso, M., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Cilmo, M., Clay, R. W., Cocciolo, G., Colalillo, Roberta, Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Cordier, A., Coutu, S., Covault, C. E., Cronin, J., Dallier, R., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., De Almeida, R. M., De Jong, S. J., De Mauro, G., De Mello Neto, J. R. T., De Mitri, I., De Oliveira, J., De Souza, V., Del Peral, L., Deligny, O., Dhital, N., Di Giulio, C., Di Matteo, A., Diaz, J. C., Díaz Castro, M. L., Diogo, F., Dobrigkeit, C., Docters, W., D'Olivo, J. C., Dorofeev, A., Dorosti Hasankiadeh, Q., Dos Anjos, R. C., Dova, M. T., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., García, B., Garcia Gamez, D., Garcia Pinto, D., Gate, F., Gemmeke, H., Gherghel Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Gómez Berisso, M., Gómez Vitale, P. F., González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Griffith, N., Grillo, A. F., Grubb, T. D., Guarino, Fausto, Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Hartmann, S., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Hollon, N., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huber, D., Huege, T., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Jarne, C., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Kukec Mezek, G., Kunka, N., Kuotb Awad, A. W., Lahurd, D., Latronico, L., Lauer, R., Lauscher, M., Lautridou, P., Le Coz, S., Lebrun, D., Lebrun, P., Leigui De Oliveira, M. A., Letessier Selvon, A., Lhenry Yvon, I., Link, K., Lopes, L., López, R., López Casado, A., Louedec, K., Lucero, A., Malacari, M., Mallamaci, M., Maller, J., Mandat, D., Mantsch, P., Mariazzi, A. G., Marin, V., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Martínez Bravo, O., Martraire, D., Masías Meza, J. J., Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mayotte, E., Mazur, P. O., Medina, C., Medina Tanco, G., Meissner, R., Mello, V. B. B., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Molina Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Moura, C. A., Muller, M. A., Müller, G., Müller, S., Navas, S., Necesal, P., Nellen, L., Nelles, A., Neuser, J., Nguyen, P. H., Niculescu Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Pacheco, N., Pakk Selmi Dei, D., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pkala, J., Pelayo, R., Pepe, I. M., Perrone, L., Petermann, E., Peters, C., Petrera, S., Petrov, Y., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porcelli, A., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Rautenberg, J., Ravel, O., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., Rodrigues De Carvalho, W., Rodriguez Rojo, J., Rodríguez Frías, M. D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Salesa Greus, F., Salina, G., Sanabria Gomez, J. 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R, Sommers, P, Sonntag, S, Sorokin, J, Squartini, R, Srivastava, Y. N, Stanca, D, Stanič, S, Stapleton, J, Stasielak, J, Stephan, M, Stutz, A, Suarez, F, Suarez Durán, M, Suomijärvi, T, Supanitsky, A. D, Sutherland, M. S, Swain, J, Szadkowski, Z, Taborda, O. A, Tapia, A, Tepe, A, Theodoro, V. M, Timmermans, C, Todero Peixoto, C. J, Toma, G, Tomankova, L, Tomé, B, Tonachini, A, Torralba Elipe, G, Torres Machado, D, Travnicek, P, Trini, M, Ulrich, R, Unger, M, Urban, M, Valdés Galicia, J. F, Valiño, I, Valore, L, van Aar, G, van Bodegom, P, van den Berg, A. M, van Velzen, S, van Vliet, A, Varela, E, Vargas Cárdenas, B, Varner, G, Vasquez, R, Vázquez, J. R, Vázquez, R. A, Veberič, D, Verzi, V, Vicha, J, Videla, M, Villaseñor, L, Vlcek, B, Vorobiov, S, Wahlberg, H, Wainberg, O, Walz, D, Watson, A. A, Weber, M, Weidenhaupt, K, Weindl, A, Welling, C, Werner, F, Widom, A, Wiencke, L, Wilczyński, H, Winchen, T, Wittkowski, D, Wundheiler, B, Wykes, S, Yang, L, Yapici, T, Yushkov, A, Zas, E, Zavrtanik, D, Zavrtanik, M, Zepeda, A, Zimmermann, B, Ziolkowski, M, Elementary Particle Physics, and Physics
Subjects: Ciencias Físicas, Astronomy, General Physics and Astronomy, ultra-high energy cosmic rays, Astrophysics, 01 natural sciences, High Energy Physics - Experiment, purl.org/becyt/ford/1 [https], High Energy Physics - Experiment (hep-ex), CODALEMA, Observatory, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Range (particle radiation), Radio detector, TUNKA-REX, Settore FIS/01 - Fisica Sperimentale, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Radio Technique, Física nuclear, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, radio emission, CIENCIAS NATURALES Y EXACTAS, Radio wave, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Cosmic ray, Astrophysics::Cosmology and Extragalactic Astrophysics, Physics and Astronomy (all), 0103 physical sciences, extensive air showers, High Energy Physics, ultra-high energy cosmic rays, extensive air showers, radio emission, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Cosmic rays, Pierre Auger Observatory, 010308 nuclear & particles physics, Radiant energy, Física, LOFAR, purl.org/becyt/ford/1.3 [https], ASTROFÍSICA, SIMULATIONS, Computational physics, Astronomía, COREAS, Experimental High Energy Physics, ARRAY, EMISSION, SIMULATIONS, LOFAR, EMISSION
Abstract: We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8±0.7(stat)±6.7(syst) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principles calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory., La lista completa de autores que integran el documento puede consultarse en el archivo, Instituto de Física La Plata
Published: 2016
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20. Search for ultrarelativistic magnetic monopoles with the Pierre Auger Observatory

Author: Johannes Schulz, M. Pimenta, A. Aab, J. Biteau, E.M. Holt, A. Saleh, L. Caramete, Maria-Teresa Dova, M. R. Hampel, H. Gemmeke, Florian Lukas Briechle, M. I. Micheletti, Sarka Wykes, D. Torres Machado, Octavian Fratu, Paula Gina Isar, F. Salesa Greus, R.C. dos Anjos, Julian Rautenberg, J. Espadanal, M. Palatka, G. Cataldi, A. C. Fauth, Luis A. Nunez, Carla Bonifazi, Jose A. Bellido, Jaime Alvarez-Muñiz, G. Kukec Mezek, John N. Matthews, R. M. Kieckhafer, E. Varela, J.D. Sanabria Gomez, D. Yelos, M. E. Bertaina, I. Naranjo, A. Menshikov, R. Sarmento, S. Sonntag, Marcus Niechciol, Jesús Peña-Rodríguez, O. Wainberg, Alexandru Gherghel-Lascu, T. Suomijärvi, A. van Vliet, Andreas Haungs, B. García, Tobias Winchen, Antonio Bueno, M. Josebachuili, L. Lopes, Alberto Daniel Supanitsky, G. De Mauro, C. A. Sarmiento, I.D. Vergara Quispe, A. Dorofeev, Gualberto Avila, R. López, Ingomar Allekotte, Jörg R. Hörandel, Karen S. Caballero-Mora, F. Canfora, Z. Zong, Diego Harari, B. Gookin, S. Querchfeld, M. Zavrtanik, Paul Sommers, A. Blanco, L. Ochilo, Angela V. Olinto, C. Di Giulio, Markus Roth, J. F. Valdés Galicia, Miroslav Hrabovský, I. De Mitri, Dieter Heck, P. Gouffon, Igor Katkov, P. H. Nguyen, E. M. Santos, L. Niemietz, R.J. Barreira Luz, G. P. Guedes, Toshihiro Fujii, G. A. Anastasi, P. Abreu, Martin Urban, A. Kuotb Awad, J. L. Harton, S. G. Blaess, B. Vargas Cárdenas, Fausto Guarino, J. Pallotta, E. J. Quel, M. J. Cooper, F. Sánchez, Q. Luce, Carlos Medina, Martin Erdmann, D. Ravignani, I. A. Minaya, B. Keilhauer, André Schulz, L. Villaseñor, Luis A. Anchordoqui, J. Debatin, Peter Hansen, Tim Niggemann, Peter Buchholz, D. Nosek, Bruce R. Dawson, A. Fuster, Tim Huege, H. Glass, I. Valiño, S. J. Sciutto, Katrin Link, Valerio Pirronello, M. A. Leigui de Oliveira, I.M. Brancus, M. Platino, Danielle LaHurd, Olivier Deligny, J. Neuser, Johannes Schumacher, C. Aramo, Juan Carlos D'Olivo, Roger W Clay, B. Revenu, J. R. Vázquez, G. S. Varner, Marco Aglietta, V. Scherini, Esteban Roulet, M. Suarez Durán, Andreas Weindl, B. Mitrica, Heino Falcke, Francesco Strafella, I. C. Mariş, Hernan Wahlberg, C. J. Todero Peixoto, Stefano D'Amico, P. Sanchez-Lucas, P. Kasper, M. Gómez Berisso, M. Ambrosio, R. C. Shellard, F. Salamida, J. Stasielak, S. Coutu, J. Vicha, Norberto Fazzini, D. Garcia-Pinto, Miroslav Pech, R. R. Prado, Petr Schovanek, Antonio Insolia, Maria Rita Coluccia, Bruno Daniel, A. Parra, Foteini Oikonomou, J. J. Masías Meza, Jeffrey A. Johnsen, S. Quinn, Günter Sigl, D. Nitz, Andrej Dundovic, Lorenzo Caccianiga, V. M. Theodoro, Dusan Mandat, P. Ristori, M. Trini, Alexandra Saftoiu, Alina Mihaela Badescu, I. Lhenry-Yvon, A. Cancio, Pavel Horvath, N. Krohm, G. Rodriguez Fernandez, G. Torralba Elipe, R. Krause, P. Stassi, C. Porowski, M. Prouza, V. Verzi, Mariangela Settimo, J. Rodriguez Rojo, Nicolás González, Radomir Smida, S. Müller, Jan Pękala, A. E. Herve, L. R. Wiencke, B. Sarkar, H. Nožka, Jose Chinellato, Christian Glaser, A. Yushkov, B. Andrada, Marco Torri, J. D. Swain, David Schmidt, M. L. Díaz Castro, G. Farrar, Carola Dobrigkeit, M. Plum, A. G. Chavez, A. Gorgi, Denis Stanca, Sofia Andringa, R. Cester, Nicusor Arsene, A. Tapia, Florian Gaté, M. Kleifges, D. Zavrtanik, B. Tome, Peter Mazur, G. Müller, V. de Souza, Max Malacari, Lili Yang, Enrique Zas, Alan Watson, A. Di Matteo, Francesca Zuccarello, A. Letessier-Selvon, Denise Boncioli, B. Wundheiler, H. Wilczyński, P. Billoir, Dariusz Glas, Fernando Contreras, O. Kambeitz, Corinne Berat, E. Mayotte, K. H. Becker, M. Unger, Gregory R Snow, A. Segreto, Philipp Papenbreer, Lorenzo Cazon, Q. Hasankiadeh, Mihai Niculescu-Oglinzanu, J. Alvarez Castillo, L. Molina-Bueno, D. Melo, I. Al Samarai, Piotr Homola, David Walz, Ana Martina Botti, I. Jandt, F. Diogo, R. M. de Almeida, G. Marsella, Marco Giammarchi, R. Squartini, T. Paul, L. A. S. Pereira, Maria Giller, A. Taboada, D. Pakk Selmi-Dei, R. Sato, L. Nellen, Ralf Ulrich, C. Morello, P.F. Gómez Vitale, G. C. Hill, R. A. Vázquez, Gaia Silli, Ralph Engel, A. Filipčič, Paul M. Mantsch, F. Sarazin, A. Bridgeman, G. Medina-Tanco, J. Ridky, G. van Aar, D. Reinert, Marc Weber, M. Mallamaci, Tanguy Pierog, S. J. Saffi, F. G. Schröder, Benedikt Zimmermann, Rúben Conceição, Zbigniew Szadkowski, Peter L. Biermann, Rodrigo Pelayo, Stijn Buitink, E. Santos, R. Piegaia, Markus Lauscher, F. Pedreira, A. Śmiałkowski, J. Phuntsok, M. M. Freire, R. Ramos-Pollan, Paolo Privitera, J. Hulsman, W. Rodrigues de Carvalho, J. W. Cronin, P. van Bodegom, P. Lebrun, Nataliia Borodai, Lukas Middendorf, Christine Peters, Hernán Asorey, Martina Bohacova, J. Sorokin, S. J. De Jong, V. Novotny, L. Valore, Rossella Caruso, A. Lucero, S. Mathys, M. Erfani, Octavian Sima, Ugo Giaccari, F. Montanet, Petr Travnicek, M. Schauer, Alan Coleman, Trent D. Grubb, Juan Manuel Figueira, Roberta Colalillo, A. G. Mariazzi, J. R. T. de Mello Neto, Peter Gorham, P. L. Ghia, Charles Timmermans, L. Collica, Marcio Aparecido Muller, L. Perrone, Jiri Chudoba, Thomas Harrison, P. Pieroni, F. Arqueros, N. Kunka, R. Gaior, F. Suarez, Thomas Hebbeker, Sergio Dasso, Tristan Sudholz, Hermann-Josef Mathes, Kai Daumiller, J. A.J. Matthews, Xavier Bertou, Jeffrey Brack, Olaf Scholten, A. Zepeda, Humberto Ibarguen Salazar, Pedro Assis, Harald Schieler, A. Etchegoyen, P. Heimann, E. Kemp, Serguei Vorobiov, D. Mockler, O. A. Taborda, H. Martinez, Miguel Mostafa, L. Tomankova, A. López Casado, Brian Fick, Samo Stanič, J. J. Beatty, Silvia Mollerach, G. Matthiae, Julien Aublin, A. Shadkam, D. Martello, S. Jansen, David Wittkowski, A. C. Rovero, C. Bleve, Alexandru Balaceanu, Vincenzo Rizi, M. Ziolkowski, O. Martínez Bravo, Thomas Bretz, Corbin Covault, Geraldina Golup, Alexander Grillo, Lino Miramonti, M. Risse, Jonathan Blazek, G. Parente, Carlos Hojvat, R. Legumina, M. Buscemi, Jan Ebr, Sergio Petrera, D. Rogozin, J. de Oliveira, H.O. Klages, Alejandro Almela, S. Messina, Julian Kemp, Gaetano Salina, Michael Schimp, A.M. van den Berg, Darko Veberič, Alex Kääpä, Colin Baus, J. Kleinfeller, Daniel Kuempel, Carlos Escobar, Ivone F. M. Albuquerque, Ke Fang, Karl-Heinz Kampert, Antonella Castellina, Research unit Astroparticle Physics, Research unit Nuclear & Hadron Physics, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Pierre Auger, Aab A., Abreu P., Aglietta M., Al Samarai I., Albuquerque I.F.M., Allekotte I., Almela A., Alvarez Castillo J., Alvarez-Muñiz J., Ambrosio M., Anastasi G.A., Anchordoqui L., Andrada B., Andringa S., Aramo C., Arqueros F., Arsene N., Asorey H., Assis P., Aublin J., Avila G., Badescu A.M., Balaceanu A., Barreira Luz R.J., Baus C., Beatty J.J., Becker K.H., Bellido J.A., Berat C., Bertaina M.E., Bertou X., Biermann P.L., Billoir P., Biteau J., Blaess S.G., Blanco A., Blazek J., Bleve C., Boháčová M., Boncioli D., Bonifazi C., Borodai N., Botti A.M., Brack J., Brancus I., Bretz T., Bridgeman A., Briechle F.L., Buchholz P., Bueno A., Buitink S., Buscemi M., Caballero-Mora K.S., Caccianiga L., Cancio A., Canfora F., Caramete L., Caruso R., Castellina A., Cataldi G., Cazon L., Cester R., Chavez A.G., Chinellato J.A., Chudoba J., Clay R.W., Colalillo R., Coleman A., Collica L., Coluccia M.R., Conceição R., Contreras F., Cooper M.J., Coutu S., Covault C.E., Cronin J., D'Amico S., Daniel B., Dasso S., Daumiller K., Dawson B.R., de Almeida R.M., de Jong S.J., De Mauro G., de Mello Neto J.R.T., De Mitri I., de Oliveira J., de Souza V., Debatin J., Deligny O., Di Giulio C., Di Matteo A., Díaz Castro M.L., Diogo F., Dobrigkeit C., D'Olivo J.C., Dorofeev A., dos Anjos R.C., Dova M.T., Dundovic A., Ebr J., Engel R., Erdmann M., Erfani M., Escobar C.O., Espadanal J., Etchegoyen A., Falcke H., Fang K., Farrar G., Fauth A.C., Fazzini N., Fick B., Figueira J.M., Filipčič A., Fratu O., Freire M.M., Fujii T., Fuster A., Gaior R., García B., Garcia-Pinto D., Gaté F., Gemmeke H., Gherghel-Lascu A., Ghia P.L., Giaccari U., Giammarchi M., Giller M., Głas D., Glaser C., Glass H., Golup G., Gómez Berisso M., Gómez Vitale P.F., González N., Gookin B., Gorgi A., Gorham P., Gouffon P., Grillo A.F., Grubb T.D., Guarino F., Guedes G.P., Hampel M.R., Hansen P., Harari D., Harrison T.A., Harton J.L., Hasankiadeh Q., Haungs A., Hebbeker T., Heck D., Heimann P., Herve A.E., Hill G.C., Hojvat C., Holt E., Homola P., Hörandel J.R., Horvath P., Hrabovský M., Huege T., Hulsman J., Insolia A., Isar P.G., Jandt I., Jansen S., Johnsen J.A., Josebachuili M., Kääpä A., Kambeitz O., Kampert K.H., Kasper P., Katkov I., Keilhauer B., Kemp E., Kemp J., Kieckhafer R.M., Klages H.O., Kleifges M., Kleinfeller J., Krause R., Krohm N., Kuempel D., Kukec Mezek G., Kunka N., Kuotb Awad A., Lahurd D., Lauscher M., Lebrun P., Legumina R., Leigui de Oliveira M.A., Letessier-Selvon A., Lhenry-Yvon I., Link K., Lopes L., López R., López Casado A., Luce Q., Lucero A., Malacari M., Mallamaci M., Mandat D., Mantsch P., Mariazzi A.G., Mariş I.C., Marsella G., Martello D., Martinez H., Martínez Bravo O., Masías Meza J.J., Mathes H.J., Mathys S., Matthews J., Matthews J.A.J., Matthiae G., Mayotte E., Mazur P.O., Medina C., Medina-Tanco G., Melo D., Menshikov A., Messina S., Micheletti M.I., Middendorf L., Minaya I.A., Miramonti L., Mitrica B., Mockler D., Molina-Bueno L., Mollerach S., Montanet F., Morello C., Mostafá M., Müller G., Muller M.A., Müller S., Naranjo I., Nellen L., Neuser J., Nguyen P.H., Niculescu-Oglinzanu M., Niechciol M., Niemietz L., Niggemann T., Nitz D., Nosek D., Novotny V., Nožka H., Núñez L.A., Ochilo L., Oikonomou F., Olinto A., Pakk Selmi-Dei D., Palatka M., Pallotta J., Papenbreer P., Parente G., Parra A., Paul T., Pech M., Pedreira F., Pękala J., Pelayo R., Peña-Rodriguez J., Pereira L. A. S., Perrone L., Peters C., Petrera S., Phuntsok J., Piegaia R., Pierog T., Pieroni P., Pimenta M., Pirronello V., Platino M., Plum M., Porowski C., Prado R.R., Privitera P., Prouza M., Quel E.J., Querchfeld S., Quinn S., Ramos-Pollan R., Rautenberg J., Ravignani D., Reinert D., Revenu B., Ridky J., Risse M., Ristori P., Rizi V., Rodrigues de Carvalho W., Rodriguez Fernandez G., Rodriguez Rojo J., Rogozin D., Roth M., Roulet E., Rovero A.C., Saffi S.J., Saftoiu A., Salamida F., Salazar H., Saleh A., Salesa Greus F., Salina G., Sanabria Gomez J.D., Sánchez F., Sanchez-Lucas P., Santos E.M., Santos E., Sarazin F., Sarkar B., Sarmento R., Sarmiento C.A., Sato R., Schauer M., Scherini V., Schieler H., Schimp M., Schmidt D., Scholten O., Schovánek P., Schröder F.G., Schulz A., Schulz J., Schumacher J., Sciutto S.J., Segreto A., Settimo M., Shadkam A., Shellard R.C., Sigl G., Silli G., Sima O., Śmiałkowski A., Šmída R., Snow G.R., Sommers P., Sonntag S., Sorokin J., Squartini R., Stanca D., Stanič S., Stasielak J., Stassi P., Strafella F., Suarez F., Suarez Durán M., Sudholz T., Suomijärvi T., Supanitsky A.D., Swain J., Szadkowski Z., Taboada A., Taborda O.A., Tapia A., Theodoro V.M., Timmermans C., Todero Peixoto C.J., Tomankova L., Tomé B., Torralba Elipe G., Torres Machado D., Torri M., Travnicek P., Trini M., Ulrich R., Unger M., Urban M., Valdés Galicia J.F., Valiño I., Valore L., van Aar G., van Bodegom P., van den Berg A.M., van Vliet A., Varela E., Vargas Cárdenas B., Varner G., Vázquez J.R., Vázquez R.A., Veberič D., Vergara Quispe I.D., Verzi V., Vicha J., Villaseñor L., Vorobiov S., Wahlberg H., Wainberg O., Walz D., Watson A.A., Weber M., Weindl A., Wiencke L., Wilczyński H., Winchen T., Wittkowski D., Wundheiler B., Wykes S., Yang L., Yelos D., Yushkov A., Zas E., Zavrtanik D., Zavrtanik M., Zepeda A., Zimmermann B., Ziolkowski M., Zong Z., Zuccarello F., Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Aab, A., Abreu, P., Aglietta, M., Al Samarai, I., Albuquerque, I. F. M., Allekotte, I., Almela, A., Alvarez Castillo, J., Alvarez Muñiz, J., Ambrosio, M., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Barreira Luz, R. J., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, Carla, Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, MARIA RITA, Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, Stefano, Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., de Mello Neto, J. R. T., DE MITRI, Ivan, de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Díaz Castro, M. L., Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorofeev, A., dos Anjos, R. C., Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia Pinto, D., Gaté, F., Gemmeke, H., Gherghel Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Gómez Berisso, M., Gómez Vitale, P. F., González, N., Gookin, B., Gorgi, A., Gorham, P., Gouffon, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Kukec Mezek, G., Kunka, N., Kuotb Awad, A., Lahurd, D., Lauscher, M., Lebrun, P., Legumina, R., Leigui de Oliveira, M. A., Letessier Selvon, A., Lhenry Yvon, I., Link, K., Lopes, L., López, R., López Casado, A., Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, Giovanni, Martello, Daniele, Martinez, H., Martínez Bravo, O., Masías Meza, J. J., Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina Tanco, G., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Molina Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, G., Muller, M. A., Müller, S., Naranjo, I., Nellen, L., Neuser, J., Nguyen, P. H., Niculescu Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Pakk Selmi Dei, D., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña Rodriguez, J., Pereira, L. A. S., Perrone, Lorenzo, Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos Pollan, R., Rautenberg, J., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., Rodrigues de Carvalho, W., Rodriguez Fernandez, G., Rodriguez Rojo, J., Rogozin, D., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Salesa Greus, F., Salina, G., Sanabria Gomez, J. D., Sánchez, F., Sanchez Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, Francesco, Suarez, F., Suarez Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Todero Peixoto, C. J., Tomankova, L., Tomé, B., Torralba Elipe, G., Torres Machado, D., Torri, M., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Valdés Galicia, J. F., Valiño, I., Valore, L., van Aar, G., van Bodegom, P., van den Berg, A. M., van Vliet, A., Varela, E., Vargas Cárdenas, B., Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Vergara Quispe, I. D., Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., Zuccarello, F., Bleve, C., Colalillo, Roberta, Coluccia, M. R., D'Amico, S., De Almeida, R. M., De Jong, S. J., De Mello Neto, J. R. T., De Mitri, I., De Oliveira, J., De Souza, V., Dos Anjos, R. C., Guarino, Fausto, Leigui De Oliveira, M. A., Marsella, G., Martello, D., Pkala, J., Perrone, L., Rodrigues De Carvalho, W., Strafella, F., Valore, Laura, Van Aar, G., Van Bodegom, P., Van Den Berg, A. M., and Van Vliet, A.
Subjects: FLUORESCENCE YIELD, Astronomy, magnetic monopole, magnetic field, Astrophysics, 7. Clean energy, 01 natural sciences, Observatory, UHE Cosmic Rays, air-shower, Monte Carlo, 010303 astronomy & astrophysics, Magnetic Monopoles, media_common, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Settore FIS/01 - Fisica Sperimentale, Astrophysics::Instrumentation and Methods for Astrophysics, critical phenomena, ENERGY LOSS, DETECTOR, Auger, Magnetic field, observatory, Lorentz factor, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, symbols, Física nuclear, fluorescence, Astrophysics - High Energy Astrophysical Phenomena, spatial distribution [showers], Lorentz, atmosphere [showers], energy, FLUX, Nuclear and High Energy Physics, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], air, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, UHE [cosmic radiation], Magnetic monopole, FOS: Physical sciences, Cosmic ray, Nuclear physics, symbols.namesake, cosmic rays, 0103 physical sciences, ddc:530, High Energy Physics, Ciencias Exactas, fluorescence [detector], Pierre Auger Observatory, background, 010308 nuclear & particles physics, Física, ASTROFÍSICA, Universe, flux, ultrarelativistic magnetic monopoles, Air shower, 13. Climate action, Experimental High Energy Physics, relativistic, galaxy, ENERGY-LOSS
Abstract: We present a search for ultra-relativistic magnetic monopoles with the Pierre Auger Observatory. Such particles, possibly a relic of phase transitions in the early universe, would deposit a large amount of energy along their path through the atmosphere, comparable to that of ultrahigh-energy cosmic rays (UHECRs). The air shower profile of a magnetic monopole can be effectively distinguished by the fluorescence detector from that of standard UHECRs. No candidate was found in the data collected between 2004 and 2012, with an expected background of less than 0.1 event from UHECRs. The corresponding 90% confidence level (C.L.) upper limits on the flux of ultra-relativistic magnetic monopoles range from 10⁻¹⁹ (cm² sr s)⁻¹ for a Lorentz factor γ = 10⁹ to 2.5 × 10⁻²¹ (cm² sr s)⁻¹ for γ = 10¹². These results -the first obtained with a UHECR detector- improve previously published limits by up to an order of magnitude., La lista completa de autores que integran el documento puede consultarse en el archivo., Facultad de Ciencias Exactas, Instituto de Física La Plata
Published: 2016
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21. High survival of mouse oocytes/embryos after vitrification without permeating cryoprotectants followed by ultra-rapid warming with an IR laser pulse

Author: Peter Mazur and Bo Jin
Subjects: Osmosis, Cryoprotectant, Cell Survival, Ir laser, Biology, Cryopreservation, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Cryoprotective Agents, Botany, Cryoprotective Agent, Animals, Vitrification, 030304 developmental biology, 0303 health sciences, 030219 obstetrics & reproductive medicine, Multidisciplinary, Pulse (signal processing), Embryo, Embryo, Mammalian, 13. Climate action, Biophysics, Oocytes, Female
Abstract: Vitrification is now the main route to the cryopreservation of human and animal oocytes and preimplantation embryos. A central belief is that for success, the cells must be placed in very high concentrations of cryoprotective solutes and must be cooled extremely rapidly. We have shown recently that these beliefs are incorrect. Over 90% of mouse oocytes and embryos survive being cooled relatively slowly even in solutions containing only 1/3rd the normal solute concentrations, provided that they are warmed ultra-rapidly at 107°C/min by a laser pulse. Nearly all vitrification solutions contain both permeating and non-permeating solutes and an important question is whether the former protect because they permeate the cells and promote intracellular vitrification (as is almost universally believed), or because they osmotically withdraw a large fraction of intracellular water prior to cooling. The answer for the mouse system is clearly the latter. When oocytes or embryos are placed in 1 molal concentrations of the impermeable solute sucrose, they osmotically lose ~85% of their cellular water in less than 2 minutes. If the cells are then cooled rapidly to −196°C, nearly 90% remain viable after warming, again provided that the warming is ultra rapid.
Published: 2015

22. Muons in air showers at the Pierre Auger Observatory

Author: D. Pakk Selmi-Dei, D. Maurizio, Johannes Schumacher, F. Salamida, Lorenzo Caccianiga, V. M. Theodoro, Y. Guardincerri, B. Tome, G. Müller, A. J. Matthews, R. Mussa, Alberto Daniel Supanitsky, A. Śmiałkowski, Markus Roth, C. Morello, Fausto Guarino, Matthias Kleifges, David Wittkowski, Germano Guedes, Danielle LaHurd, Olivier Deligny, Peter L. Biermann, Dusan Mandat, A. van Vliet, Eric Mayotte, Paolo Privitera, M. Gómez Berisso, R. C. Shellard, W. Docters, Yogendra N. Srivastava, M. I. Micheletti, E. Varela, N. Griffith, S. Grebe, M. Zavrtanik, Markus Risse, B. Wilczynska, R. Squartini, John L. Harton, Fred Sarazin, Lukas Nellen, T. Paul, Arnulfo Zepeda, R. Meyhandan, P. Abreu, Antonio Insolia, G. Torralba Elipe, F. Sánchez, Sergio Sciutto, L. Ochilo, D. Ravignani, G. Cocciolo, Eva Santos, R. Krause, Federico Suarez, B. Zamorano, Iván Sidelnik, Luis A. Anchordoqui, I. Al Samarai, Sasa Micanovic, Gaetano Salina, Rúben Conceição, L. Valore, Amin Aminaei, E.M. Holt, J. J. Beatty, Norbert Kunka, S. Messina, Azadeh Keivani, Ricardo Vázquez, W. Rodrigues de Carvalho, Maria Giller, A. Saleh, Maria-Teresa Dova, D. Nitz, Silvia Mollerach, B. Vlcek, H. Dembinski, G. Matthiae, M. Tartare, Darko Veberič, I. Zaw, M. Platino, M. Monasor, C. Aramo, J. W. Cronin, G. van Aar, Moritz Münchmeyer, R. Alves Batista, M. Ambrosio, G. C. Hill, Q. Dorosti Hasankiadeh, Tobias Winchen, P. Lebrun, Karen S. Caballero-Mora, B. Mitrica, Heino Falcke, Ralph Engel, V. Marin, Valerio Pirronello, L. Perrone, Sarka Wykes, Marco Giammarchi, J. Vicha, S. Quinn, A. Segreto, M. Ludwig, S. Hartmann, Jing Zhou, Julien Aublin, F. Werner, Jan Ridky, A. Stutz, P. Allison, V. Scherini, Martin Erdmann, G. Toma, Nataliia Borodai, E. J. Ahn, Paul Sommers, D. Martello, M. Blanco, R. Bonino, Michael Unger, S. Jansen, P. Gouffon, François Montanet, S. van Velzen, K. H. Becker, A. G. Mariazzi, K. Islo, Radomir Smida, Beatriz García, Octavian Fratu, D. Torres Machado, D. Melo, Roger W Clay, M. J. Cooper, A. Gorgi, Miroslav Palatka, S. J. De Jong, N. Krohm, Jose Chinellato, P. Lautridou, S. Navas, Johannes Schulz, M. Melissas, M. Will, B. Sarkar, Christian Glaser, M. Pimenta, Carlos Medina, M. De Domenico, Joshua A. Gordon, M. Avenier, A. Curutiu, A. Widom, Daniel Kuempel, M. Ave, Carlos Escobar, A. Filipčič, A. C. Rovero, Paula Gina Isar, C. Bleve, Pedro Brogueira, F. Salesa Greus, G. Cataldi, J. Espadanal, J. F. Valdés Galicia, I. De Mitri, A. Gascon Bravo, Dieter Heck, Martin Urban, V. de Souza, N. Palmieri, Ugo Giaccari, M. Zimbres Silva, A. Cordier, S. Maldera, P. W. Younk, Ivone F. M. Albuquerque, Ke Fang, C. J. Todero Peixoto, R. López, E. Trovato, J. Stapleton, Marc Weber, P. Billoir, Tanguy Pierog, M. E. Bertaina, Jörg R. Hörandel, G. Garilli, Lorenzo Cazon, Vincenzo Rizi, A. Menshikov, B. Gookin, S. T. Garcia Roca, Toshihiro Fujii, R. Sato, J. R. T. de Mello Neto, M. Ziolkowski, L. del Peral, O. Ravel, O. Martínez Bravo, E. M. Santos, K. Louedec, Mariangela Settimo, A. Shadkam, M. Buscemi, Maria Rita Coluccia, Alexey Yushkov, Bruno Daniel, K. Weidenhaupt, Bruce R. Dawson, N. Scharf, Antonio Bueno, M. Josebachuili, V. Purrello, P. Heimann, Tim Huege, H. Blümer, Max Malacari, Carlos Hojvat, D. Nosek, Juan Carlos D'Olivo, T. Yapici, D. Newton, Ernesto Kemp, Esteban Roulet, Piotr Homola, Lukas Middendorf, Jan Ebr, Serguei Vorobiov, Sergio Petrera, Christine Peters, J. J. Masías Meza, P. Facal San Luis, D. Maurel, H. Schoorlemmer, Gualberto Avila, Gustavo Medina-Tanco, Nicolás González, Ingomar Allekotte, S. Le Coz, D. Monnier Ragaigne, M. A. Leigui de Oliveira, T. Rossler, Piera Luisa Ghia, Guenter Sigl, Thomas Hebbeker, C. L. Williams, Angela V. Olinto, O. Krömer, O. A. Taborda, Sergio Dasso, Balázs Kégl, C. Di Giulio, S. J. Saffi, H. Martinez, G. Rodriguez Fernandez, A. P. Ferguson, Hernán Asorey, Corinne Berat, C. E. Santo, B. Revenu, U. Fröhlich, A. Tapia, C. Jarne, J. de Oliveira, J. R. Vázquez, Henryk Wilczyński, Hermann-Josef Mathes, Antoine Letessier-Selvon, van den Ad M Berg, Luca Latronico, Alejandro Almela, P. Sanchez-Lucas, D. Harari, M. Oliveira, Markus Lauscher, Kai Daumiller, J. Phuntsok, M. Videla, V. M. Aranda, Jeffrey Brack, Olaf Scholten, Humberto Ibarguen Salazar, Raul Sarmento, A. Aab, F. Gate, L. Caramete, H. Gemmeke, L. Tomankova, M. Mallamaci, G. Navarra, C. A. Moura, T. Yamamoto, Brian Fick, Samo Stanič, J. Lozano Bahilo, John Swain, Philipp Papenbreer, J. S. Díaz, D. Garcia-Pinto, Petr Travnicek, Alan Coleman, Trent D. Grubb, D. Huber, Petr Schovanek, Carla Bonifazi, Juan Manuel Figueira, Roberta Colalillo, Jose A. Bellido, M. Prouza, G. Yuan, Corbin Covault, Y. Petrov, Matías Rolf Hampel, J. A.J. Matthews, Xavier Bertou, J. Rodriguez Rojo, Bianca Keilhauer, A. G. Chavez, Pedro Assis, S. Riggi, Jaime Rosado, Alina Mihaela Badescu, F.G. Schröder, Enrique Zas, I. M. Pepe, Alexander Grillo, J. Stasielak, R. Cester, S. Coutu, Norberto Fazzini, Lino Miramonti, Fernando Contreras, M. D. Rodríguez-Frías, M. A. Muller, Peter Schiffer, Paulo J. S. Gonçalves, D. Kruppke-Hansen, D. Garcia-Gamez, Alberto Etchegoyen, I. C. Mariş, J. Allen, Hernan Wahlberg, C. Porowski, Alexandra Saftoiu, A. Dorofeev, I. Jandt, A. Tepe, I. Lhenry-Yvon, Octavian Sima, J. G. Gonzalez, Ralf Ulrich, Igor Katkov, R. R. Prado, Denise Boncioli, German Ros, A. Di Matteo, Paul M. Mantsch, B. Wundheiler, A. Parra, L. Villaseñor, Miguel Mostafá, Marcus Niechciol, Anderson Fauth, Gregory R Snow, P. H. Kasper, L. Martin, M. S. A. B. Leão, D. Lebrun, R. J. Lauer, L. Nožka, G. Parente, R. Piegaia, Marco Cilmo, P. Ristori, Alex Kääpä, Peter Mazur, S. Querchfeld, Colin Baus, V. M. Olmos-Gilbaja, L. Niemietz, N. Pacheco, J. Roberts, Tim Niggemann, Yingchun Zhu, H. Schieler, M. Fernandes, B. Caccianiga, Karl-Heinz Kampert, Antonella Castellina, B. Vargas Cárdenas, R. M. Kieckhafer, J. Rautenberg, T. Suomijärvi, J. Pallotta, G. S. Varner, O. Wainberg, E. J. Quel, Béatrice Fuchs, Niraj Dhital, W. C. Brown, I. Valiño, J. Neuser, M. Candusso, Peter Gorham, Charles Timmermans, L. Collica, Jiri Chudoba, Thomas Harrison, Richard Dallier, A. Nelles, Jaime Alvarez-Muñiz, Lu Lu, P. Pieroni, I. A. Minaya, André Schulz, F. Arqueros, P. Necesal, Martina Bohacova, Jan Pękala, Hans Klages, A. Chiavassa, A. E. Herve, K. B. Barber, L. R. Wiencke, J. Sorokin, A. Porcelli, B. D. Fox, M. L. Díaz Castro, G. Farrar, Francesca Zuccarello, Maurice Stephan, A. Tonachini, P.F. Gómez Vitale, J. Maller, G. Marsella, A. Weindl, N. Hollon, V. Verzi, V. Novotny, J. Bäuml, Rossella Caruso, A. Lucero, S. Mathys, M. Erfani, E. Petermann, Miroslav Pech, Pavel Horvath, M. S. Sutherland, Danilo Zavrtanik, Sofia Andringa, K. Link, D. Martraire, Miroslav Hrabovský, A. Haungs, O. Kambeitz, F. Diogo, R. M. de Almeida, Zbigniew Szadkowski, Rodrigo Pelayo, Stijn Buitink, Alberto Filevich, Peter Hansen, R. Gaior, Peter Buchholz, M. Szuba, I.M. Brancus, Carola Dobrigkeit, H. Glass, M. Plum, Marco Aglietta, Alan Watson, Jonny Kleinfeller, J. Alvarez Castillo, L. Molina-Bueno, David Walz, Laboratoire de Physique Subatomique et de Cosmologie ( LPSC ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Unité Scientifique de la Station de Nançay ( USN ), Observatoire de Paris-Université d'Orléans ( UO ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire SUBATECH Nantes ( SUBATECH ), Mines Nantes ( Mines Nantes ) -Université de Nantes ( UN ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Physique Nucléaire d'Orsay ( IPNO ), Pierre AUGER, ANR-10-LABX-63,ANR-10-LABX-63, European Project : 328826,EC:FP7:PEOPLE,FP7-PEOPLE-2012-IEF,AUGER2FUTURE ( 2013 ), European Project : 246806,EC:FP7:PEOPLE,FP7-PEOPLE-2009-IRSES,EPLANET ( 2011 ), UNIVERSIDADE DE ESTADUAL DE CAMPINAS, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Unité Scientifique de la Station de Nançay (USN), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de Physique Nucléaire d'Orsay (IPNO), ANR-10-LABX-0063,ILP,Institute Lagrange of Paris(2010), European Project: 328826,EC:FP7:PEOPLE,FP7-PEOPLE-2012-IEF,AUGER2FUTURE(2013), European Project: 246806,EC:FP7:PEOPLE,FP7-PEOPLE-2009-IRSES,EPLANET(2011), Aab A., Abreu P., Aglietta M., Ahn E. J., Al Samarai I., Albuquerque I. F. M., Allekotte I., Allison P., Almela A., Alvarez Castillo J., Alvarez-Muñiz J., Alves Batista R., Ambrosio M., Aminaei A., Anchordoqui L., Andringa S., Aramo C., Aranda V. M., Arqueros F., Arsene N., Asorey H., Assis P., Aublin J., Ave M., Avenier M., Avila G., Awal N., Badescu A. M., Barber K. B., Bäuml J., Baus C., Beatty J. J., Becker K. H., Bellido J. A., Berat C., Bertaina M. E., Bertou X., Biermann P. L., Billoir P., Blaess S. G., Blanco A., Blanco M., Bleve C., Blümer H., Boháčová M., Boncioli D., Bonifazi C., Borodai N., Brack J., Brancus I., Bridgeman A., Brogueira P., Brown W. C., Buchholz P., Bueno A., Buitink S., Buscemi M., Caballero-Mora K. S., Caccianiga B., Caccianiga L., Candusso M., Caramete L., Caruso R., Castellina A., Cataldi G., Cazon L., Cester R., Chavez A. G., Chiavassa A., Chinellato J. A., Chudoba J., Cilmo M., Clay R. W., Cocciolo G., Colalillo R., Coleman A., Collica L., Coluccia M. R., Conceição R., Contreras F., Cooper M. J., Cordier A., Coutu S., Covault C. E., Cronin J., Dallier R., Daniel B., Dasso S., Daumiller K., Dawson B. R., de Almeida R. M., de Jong S. J., De Mauro G., de Mello Neto J. R. T., De Mitri I., de Oliveira J., de Souza V., del Peral L., Deligny O., Dembinski H., Dhital N., Di Giulio C., Di Matteo A., Diaz J. C., Díaz Castro M. L., Diogo F., Dobrigkeit C., Docters W., D’Olivo J. C., Dorofeev A., Dorosti Hasankiadeh Q., Dova M. T., Ebr J., Engel R., Erdmann M., Erfani M., Escobar C. O., Espadanal J., Etchegoyen A., Falcke H., Fang K., Farrar G., Fauth A. C., Fazzini N., Ferguson A. P., Fernandes M., Fick B., Figueira J. M., Filevich A., Filipčič A., Fox B. D., Fratu O., Freire M. M., Fuchs B., Fujii T., García B., Garcia-Pinto D., Gate F., Gemmeke H., Gherghel-Lascu A., Ghia P. L., Giaccari U., Giammarchi M., Giller M., Głas D., Glaser C., Glass H., Golup G., Gómez Berisso M., Gómez Vitale P. F., González N., Gookin B., Gordon J., Gorgi A., Gorham P., Gouffon P., Griffith N., Grillo A. F., Grubb T. D., Guardincerri Y., Guarino F., Guedes G. P., Hampel M. R., Hansen P., Harari D., Harrison T. A., Hartmann S., Harton J. L., Haungs A., Hebbeker T., Heck D., Heimann P., Herve A. E., Hill G. C., Hojvat C., Hollon N., Holt E., Homola P., Hörandel J. R., Horvath P., Hrabovský M., Huber D., Huege T., Insolia A., Isar P. G., Jandt I., Jansen S., Jarne C., Johnsen J. A., Josebachuili M., Kääpä A., Kambeitz O., Kampert K. H., Kasper P., Katkov I., Kégl B., Keilhauer B., Keivani A., Kemp E., Kieckhafer R. M., Klages H. O., Kleifges M., Kleinfeller J., Krause R., Krohm N., Krömer O., Kuempel D., Kunka N., LaHurd D., Latronico L., Lauer R., Lauscher M., Lautridou P., Le Coz S., Lebrun D., Lebrun P., Leigui de Oliveira M. A., Letessier-Selvon A., Lhenry-Yvon I., Link K., Lopes L., López R., López Casado A., Louedec K., Lu L., Lucero A., Malacari M., Maldera S., Mallamaci M., Maller J., Mandat D., Mantsch P., Mariazzi A. G., Marin V., Mariş I. C., Marsella G., Martello D., Martin L., Martinez H., Martínez Bravo O., Martraire D., Masías Meza J. J., Mathes H. J., Mathys S., Matthews J., Matthews J. A. J., Matthiae G., Maurel D., Maurizio D., Mayotte E., Mazur P. O., Medina C., Medina-Tanco G., Meissner R., Mello V. B. B., Melo D., Menshikov A., Messina S., Meyhandan R., Micheletti M. I., Middendorf L., Minaya I. A., Miramonti L., Mitrica B., Molina-Bueno L., Mollerach S., Montanet F., Morello C., Mostafá M., Moura C. A., Muller M. A., Müller G., Müller S., Mussa R., Navarra G., Navarro J. L., Navas S., Necesal P., Nellen L., Nelles A., Neuser J., Nguyen P. H., Niculescu-Oglinzanu M., Niechciol M., Niemietz L., Niggemann T., Nitz D., Nosek D., Novotny V., Nožka L., Ochilo L., Oikonomou F., Olinto A., Pacheco N., Pakk Selmi-Dei D., Palatka M., Pallotta J., Papenbreer P., Parente G., Parra A., Paul T., Pech M., Pȩkala J., Pelayo R., Pepe I. M., Perrone L., Petermann E., Peters C., Petrera S., Petrov Y., Phuntsok J., Piegaia R., Pierog T., Pieroni P., Pimenta M., Pirronello V., Platino M., Plum M., Porcelli A., Porowski C., Prado R. R., Privitera P., Prouza M., Purrello V., Quel E. J., Querchfeld S., Quinn S., Rautenberg J., Ravel O., Ravignani D., Revenu B., Ridky J., Riggi S., Risse M., Ristori P., Rizi V., Rodrigues de Carvalho W., Rodriguez Fernandez G., Rodriguez Rojo J., Rodríguez-Frías M. D., Rogozin D., Rosado J., Roth M., Roulet E., Rovero A. C., Saffi S. J., Saftoiu A., Salamida F., Salazar H., Saleh A., Salesa Greus F., Salina G., Sánchez F., Sanchez-Lucas P., Santos E., Santos E. M., Sarazin F., Sarkar B., Sarmento R., Sato R., Scarso C., Schauer M., Scherini V., Schieler H., Schiffer P., Schmidt D., Scholten O., Schoorlemmer H., Schovánek P., Schröder F. G., Schulz A., Schulz J., Schumacher J., Sciutto S. J., Segreto A., Settimo M., Shadkam A., Shellard R. C., Sidelnik I., Sigl G., Sima O., Śmiałkowski A., Šmída R., Snow G. R., Sommers P., Sorokin J., Squartini R., Srivastava Y. N., Stanca D., Stanič S., Stapleton J., Stasielak J., Stephan M., Stutz A., Suarez F., Suomijärvi T., Supanitsky A. D., Sutherland M. S., Swain J., Szadkowski Z., Taborda O. A., Tapia A., Tepe A., Theodoro V. M., Tiffenberg J., Timmermans C., Todero Peixoto C. J., Toma G., Tomankova L., Tomé B., Tonachini A., Torralba Elipe G., Torres Machado D., Travnicek P., Ulrich R., Unger M., Urban M., Valdés Galicia J. F., Valiño I., Valore L., van Aar G., van Bodegom P., van den Berg A. M., van Velzen S., van Vliet A., Varela E., Vargas Cárdenas B., Varner G., Vasquez R., Vázquez J. 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C., Hojvat, C., Hollon, N., Holt, E., Homola, P., Hörandel, J. . R., Horvath, P., Hrabovský, M., Huber, D., Huege, T., Insolia, A., Isar, P. . G., Jandt, I., Jansen, S., Jarne, C., Johnsen, J. . A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. . H., Kasper, P., Katkov, I., Kégl, B., Keilhauer, B., Keivani, A., Kemp, E., Kieckhafer, R. . M., Klages, H. . O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Krömer, O., Kuempel, D., Kunka, N., Lahurd, D., Latronico, L., Lauer, R., Lauscher, M., Lautridou, P., Le Coz, S., Lebrun, D., Lebrun, P., Leigui de Oliveira, M. . A., Letessier Selvon, A., Lhenry Yvon, I., Link, K., Lopes, L., López, R., López Casado, A., Louedec, K., Lu, L., Lucero, A., Malacari, M., Maldera, S., Mallamaci, M., Maller, J., Mandat, D., Mantsch, P., Mariazzi, A. . G., Marin, V., Mariş, I. . C., Marsella, Giovanni, Martello, Daniele, Martin, L., Martinez, H., Martínez Bravo, O., Martraire, D., Masías Meza, J. . J., Mathes, H. . J., Mathys, S., Matthews, J., Matthews, J. . A. . J., Matthiae, G., Maurel, D., Maurizio, D., Mayotte, E., Mazur, P. . O., Medina, C., Medina Tanco, G., Meissner, R., Mello, V. . B. . B., Melo, D., Menshikov, A., Messina, S., Meyhandan, R., Micheletti, M. . I., Middendorf, L., Minaya, I. . A., Miramonti, L., Mitrica, B., Molina Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Moura, C. . A., Muller, M. . A., Müller, G., Müller, S., Mussa, R., Navarra, G., Navarro, J. . L., Navas, S., Necesal, P., Nellen, L., Nelles, A., Neuser, J., Nguyen, P. . H., Niculescu Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Ochilo, L., Oikonomou, F., Olinto, A., Pacheco, N., Pakk Selmi Dei, D., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pȩkala, J., Pelayo, R., Pepe, I. . M., Perrone, Lorenzo, Petermann, E., Peters, C., Petrera, S., Petrov, Y., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porcelli, A., Porowski, C., Prado, R. . R., Privitera, P., Prouza, M., Purrello, V., Quel, E. . J., Querchfeld, S., Quinn, S., Rautenberg, J., Ravel, O., Ravignani, D., Revenu, B., Ridky, J., Riggi, S., Risse, M., Ristori, P., Rizi, V., Rodrigues de Carvalho, W., Rodriguez Fernandez, G., Rodriguez Rojo, J., Rodríguez Frías, M. . D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. . C., Saffi, S. . J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Salesa Greus, F., Salina, G., Sánchez, F., Sanchez Lucas, P., Santos, E., Santos, E. . M., Sarazin, F., Sarkar, B., Sarmento, R., Sato, R., Scarso, C., Schauer, M., Scherini, Viviana, Schieler, H., Schiffer, P., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. . G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. . J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. . C., Sidelnik, I., Sigl, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. . R., Sommers, P., Sorokin, J., Squartini, R., Srivastava, Y. . N., Stanca, D., Stanič, S., Stapleton, J., Stasielak, J., Stephan, M., Stutz, A., Suarez, F., Suomijärvi, T., Supanitsky, A. . D., Sutherland, M. . S., Swain, J., Szadkowski, Z., Taborda, O. . A., Tapia, A., Tepe, A., Theodoro, V. . M., Tiffenberg, J., Timmermans, C., Todero Peixoto, C. . J., Toma, G., Tomankova, L., Tomé, B., Tonachini, A., Torralba Elipe, G., Torres Machado, D., Travnicek, P., Ulrich, R., Unger, M., Urban, M., Valdés Galicia, J. . F., Valiño, I., Valore, L., van Aar, G., van Bodegom, P., van den Berg, A. . M., van Velzen, S., van Vliet, A., Varela, E., Vargas Cárdenas, B., Varner, G., Vasquez, R., Vázquez, J. . R., Vázquez, R. . A., Veberič, D., Verzi, V., Vicha, J., Videla, M., Villaseñor, L., Vlcek, B., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. . A., Weber, M., Weidenhaupt, K., Weindl, A., Werner, F., Widom, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yapici, T., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zhu, Y., Zimmermann, B., Ziolkowski, M., Zuccarello, F., Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), M., Ambrosio, Aramo, Carla, Buscemi, Mario, Cilmo, Marco, Colalillo, Roberta, Guarino, Fausto, Valore, Laura, The Pierre Auger, Collaboration, Research unit Astroparticle Physics, and Research unit Nuclear & Hadron Physics
Subjects: [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Cosmic-ray interactions, Astronomy, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Cosmic ray, extensive atmospherical showers, muon density, muon number, Pierre Auger Observatory, cosmic radiation UHE, Hadronic interaction models, 7. Clean energy, Auger, Settore FIS/04 - Fisica Nucleare e Subnucleare, Nuclear physics, Altitude, Settore FIS/05 - Astronomia e Astrofisica, Observatory, NERGY COSMIC-RAYS, DETECTOR, MODEL, Extensive air showers, cosmic radiation UHE, DETECTOR, Scaling, Cosmic rays, Zenith, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Pierre Auger Observatory, Muon, NERGY COSMIC-RAYS, Settore FIS/01 - Fisica Sperimentale, energy cosmic-rays, detector, model, Astrophysics::Instrumentation and Methods for Astrophysics, Física, [ PHYS.ASTR.HE ] Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], ASTROFÍSICA, extensive atmospherical showers, muon number, MODEL, muon density, Experimental High Energy Physics, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Física nuclear, High Energy Physics::Experiment, Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present the first hybrid measurement of the average muon number in air showers at ultrahigh energies, initiated by cosmic rays with zenith angles between 62° and 80°. The measurement is based on 174 hybrid events recorded simultaneously with the surface detector array and the fluorescence detector of the Pierre Auger Observatory. The muon number for each shower is derived by scaling a simulated reference profile of the lateral muon density distribution at the ground until it fits the data. A 1019eV shower with a zenith angle of 67°, which arrives at the surface detector array at an altitude of 1450 m above sea level, contains on average (2.68±0.04±0.48(sys))×107 muons with energies larger than 0.3 GeV. The logarithmic gain dlnNμ/dlnE of muons with increasing energy between 4×1018eV and 5×1019eV is measured to be (1.029±0.024±0.030(sys))., La lista completa de autores que integran el documento puede consultarse en el archivo, Instituto de Física La Plata
Published: 2015
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23. Extra- and intra-cellular ice formation in Stage I and II Xenopus laevis oocytes

Author: Keisuke Edashige, James F. Guenther, Shinsuke Seki, Daniel M. Roberts, Peter Mazur, and Frederick W. Kleinhans
Subjects: Glycerol, Ethylene Glycol, Cryobiology, Xenopus, Pseudomonas syringae, General Biochemistry, Genetics and Molecular Biology, Cryopreservation, Xenopus laevis, Cryoprotective Agents, Freezing, Cryoprotective Agent, Botany, Extracellular, Animals, Cells, Cultured, biology, Cell Membrane, Ice, IIf, General Medicine, biology.organism_classification, Ringer's Solution, Oocytes, Melting point, Ice nucleus, Biophysics, Female, Isotonic Solutions, General Agricultural and Biological Sciences
Abstract: We are currently investigating factors that influence intracellular ice formation (IIF) in mouse oocytes and oocytes of the frog Xenopus. A major reason for choosing these two species is that while their eggs normally do not possess aquaporin channels in their plasma membranes, these channels can be made to express. We wish to see whether IIF is affected by the presence of these channels. The present Xenopus study deals with control eggs not expressing aquaporins. The main factor studied has been the effect of a cryoprotective agent [ethylene glycol (EG) or glycerol] and its concentration. The general procedure was to (a) cool the oocytes on a cryostage to slightly below the temperatures at which extracellular ice formation occurs, (b) warm them to just below the melting point, and (c) then re-cool them to -50 degrees C at 10 degrees C/min. In the majority of cases, IIF occurs well into step (c), but a sizeable minority undergo IIF in steps (a) or (b). The former group we refer to as low-temperature flashers; the latter as high-temperature flashers. IIF is manifested as abrupt blackening of the egg, which we refer to as "flashing." Observations on the Linkam cryostage are restricted to Stage I and II oocytes, which have diameters of 200 300 microm. In the absence of a cryoprotective agent, that is in frog Ringers, the mean flash temperature for the low-temperature freezers is -11.4 degrees C, although a sizeable percentage flash at temperatures much closer to that of the EIF (-3.9 degrees C). When EG is present, the flash temperature for the low-temperatures freezers drops significantly to approximately -20 degrees C for EG concentrations ranging from 0.5 to 1.5 M. The presence of 1.5 M glycerol also substantially reduces the IIF temperature of the low-temperature freezers; namely, to -29 degrees C, but 0.5 and 1 M glycerol exert little or no effect. The IIF temperatures observed using the Linkam cryostage agree well with those estimated by calorimetry [F.W. Kleinhans, J.F. Guenther, D.M. Roberts, P. Mazur, Analysis of intracellular ice nucleation in Xenopus oocytes by differential scanning calorimetry, Cryobiology 52 (2006) 128-138]. The IIF temperatures in Xenopus are substantially higher than those observed in mouse oocytes [P. Mazur, S. Seki, I.L. Pinn, F.W. Kleinhans, K. Edashige, Extra- and intracellular ice formation in mouse oocytes, Cryobiology 51 (2005) 29-53]. Perhaps that is a reflection of their much larger size.
Published: 2006
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24. Analysis of intracellular ice nucleation in Xenopus oocytes by differential scanning calorimetry

Author: Frederick W. Kleinhans, James F. Guenther, Daniel M. Roberts, and Peter Mazur
Subjects: Calorimetry, Differential Scanning, Xenopus, Cryoelectron Microscopy, Ice, Temperature, Aquaporin, IIf, General Medicine, Biology, biology.organism_classification, General Biochemistry, Genetics and Molecular Biology, Cryopreservation, Cell biology, Crystallography, Differential scanning calorimetry, Oocytes, Extracellular, Ice nucleus, Animals, Female, General Agricultural and Biological Sciences, Intracellular
Abstract: Intracellular ice formation (IIF) plays a central role in cell damage during cryopreservation. We are investigating the factors which trigger IIF in Xenopus oocytes, with and without aquaporin water channels. Here, we report differential scanning calorimeter studies of Xenopus control oocytes which do not express aquaporins. Stage I to VI oocytes (which increase progressively in size) were investigated with emphasis on stage I and II because they are translucent and can also be studied under the cryomicroscope. Measurements were made in 1, 1.5, and 2M ethylene glycol (EG) in frog Ringers plus SnoMax. A multistep freezing protocol was used in which the samples were cooled until extracellular ice formation (EIF) occurred, partially remelted, slowly recooled through the EIF temperature, and then rapidly (10 degrees C/min) cooled. EIF in the 1, 1.5, and 2M EG occurred at -6.4, -7.8, and -8.9 degrees C, respectively. Freezing exotherms of individual stage I-VI oocytes were readily visible. A general trend was observed in which the IIF temperature of the early stage oocytes (I-III) was well below T(EIF) while the later stages (IV-VI) froze at temperatures much closer to T(EIF). Thus, in 1.5M EG, T(IIF) was -21.1, -25, and -26.6 degrees C in stages I-III, but was -17 and -8.5 degrees C for stage IV and V-VI. Concurrently, the percentage of oocytes in which IIF was observed fell dramatically from a high of 40 to 72% in early stages (I-III) to a low of only 7% in stage V-VI because, particularly in the later stages, IIF was hidden in the EIF exotherm. We conclude that early stage oocytes are a good model system in which to investigate modulators of IIF, but that late stage oocytes are damaged during EIF and infrequently supercool.
Published: 2006
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25. Effects of hold time after extracellular ice formation on intracellular freezing of mouse oocytes

Author: Irina L. Pinn, Peter Mazur, Shinsuke Seki, Frederick W. Kleinhans, and Keisuke Edashige
Subjects: Ethylene Glycol, Time Factors, Cell Survival, Biology, General Biochemistry, Genetics and Molecular Biology, Mice, chemistry.chemical_compound, Freezing, Extracellular, Animals, Cryopreservation, Mice, Inbred ICR, Ice formation, Hold time, Ice, Phosphate buffered saline, IIf, General Medicine, chemistry, Biochemistry, Oocytes, Biophysics, Female, General Agricultural and Biological Sciences, Ethylene glycol, Intracellular freezing, Intracellular
Abstract: MII mouse oocytes in 1 and 1.5M ethylene glycol(EG)/phosphate buffered saline have been subjected to rapid freezing at 50 degrees C/min to -70 degrees C. When this rapid freezing is preceded by a variable hold time of 0-3 min after the initial extracellular ice formation (EIF), the duration of the hold time has a substantial effect on the temperature at which the oocytes subsequently undergo intracellular ice formation (IIF). For example, in 1M EG, the IIF temperatures are -23.7 and -39.2 degrees C with 0 and 2 min hold times; in 1.5M EG, the corresponding IIF temperatures are -29.1 and -40.8 degrees C.
Published: 2005
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26. High ice nucleation temperature of zebrafish embryos: slow-freezing is not an option

Author: Peter Mazur, A. Peterson, Frederick W. Kleinhans, and Mary Hagedorn
Subjects: Cryopreservation, animal structures, Cryobiology, Cryoprotectant, Ice, Nucleation, Epiboly, Embryo, General Medicine, Biology, General Biochemistry, Genetics and Molecular Biology, Freezing point, Cryoprotective Agents, embryonic structures, Botany, Biophysics, Ice nucleus, Animals, General Agricultural and Biological Sciences, Zebrafish
Abstract: Although fish embryos have been used in a number of slow-freezing cryopreservation experiments, they have never been successfully cryopreserved. In part this is because little is known about whether ice forms within the embryo during the slow-freezing dehydration process. Therefore, we examined the temperature of intraembryonic ice formation ( T IIF ) and the temperature of extraembryonic ice formation ( T EIF ), using a cryomicroscope. We used both unmodified zebrafish embryos and those with water channels (aquaporin-3 or AQP3) inserted into their membranes to increase permeability to water and cryoprotectants, examined at 100% epiboly to the 6-somite stage. In these experiments we examined: (1) the spontaneous freezing of (external) solutions; (2) the spontaneous freezing of solutions containing embryos; (3) the effect of preloading the embryos with cryoprotectants on T IIF ; (4) whether preloading the embryos with cryoprotectant helps in survival after nucleating events in the solution; and (5) the damaging effects of extracellular nucleation events versus solution toxicity on the embryos. The solutes alone (embryo medium—EM, sucrose culture medium, 1 M propylene glycol in EM, and 1 M propylene glycol in a sucrose culture medium) froze at −14.9 ± 1.1, −17.0 ± 0.3, −17.8 ± 1.0, and −17.7 ± 1.4, respectively. There was no difference amongst these means ( P > 0.05), thus adding cryoprotectant did not significantly lower the nucleation point. Adding embryos (preloaded with cryoprotectant or not) did not change the basic freezing characteristics of these solutes. In all these experiments, ( T EIF ) equaled ( T IIF ), and there was no difference in the freezing point of the solutions with or without the embryos ( P > 0.05). Additionally, there was no difference in the freezing characteristics of embryos with and without aquaporins ( P > 0.05). The formation of intraembryonic ice was lethal to the zebrafish embryos in all cases. But this lethal outcome was not related to solution injury effects, because 88–98% of embryos survived when exposed to a higher solute concentration with no ice present. Taken together, these data suggest that slow-freezing is not a suitable option for zebrafish embryos. The mechanism of this high temperature nucleation event in zebrafish embryos is still unknown.
Published: 2004
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27. The Pierre Auger cosmic ray observatory

Author: A. Haungs, F. Diogo, R. M. de Almeida, J. L. Harton, Harm Schoorlemmer, F. Arneodo, Stijn Buitink, S. Westerhoff, Z. Szadkowski, F. Salamida, Carola Dobrigkeit, M. Plum, M. Chiosso, M. E. Bertaina, S. G. Blaes, Alan Watson, J. Alvarez Castillo, D. Nicotra, Paul Sommers, P. Gouffon, M. J. Cooper, Dragos Varnav, C. Aramo, Carlos Medina, M. De Domenico, M. Sutter, Maria Rita Coluccia, Bruno Daniel, Q. Dorosti Hasankiadeh, T. Yapici, Foteini Oikonomou, J. J. Masías Meza, D. Maurel, Luis Villaseñor, P. Abreu, D. Ravignani, Yingchun Zhu, B. Mitrica, Heino Falcke, J. Vicha, G. Cocciolo, B. Genolini, Luis A. Anchordoqui, M. Ambrosio, G. S. Varner, H. Gemmeke, M. Monasor, M. Iarlori, C. E. Santo, L. Martina, Yogendra N. Srivastava, Andreas Kopmann, E. J. Ahn, V. Tunnicliffe, A. F. Barbosa, Dusan Mandat, Martina Bohacova, Patrick Allison, E. Varela, N. Griffith, J. Sorokin, M. Boratav, B. Revenua, T. Porter, G. Torralba Elipe, A. Gorgi, Peter Schiffer, Benedikt Zimmermann, Rúben Conceição, R. Vasquez, Pascal Lautridou, D. V. Camin, Luis N. Epele, M. Blanco, V. Scherini, Alexandra Saftoiu, O. Kambeitz, H. Martinez, A. Di Matteo, N. Martínez, N. Palmieri, B. Wundheiler, D. Nitz, I. Lhenry-Yvon, Eva Santos, R. Krause, Vincent Marin, P. Walker, Gregory R Snow, Jan Pękala, A. Chiavassa, A. Menshikov, R. Habraken, M. S. A. B. Leão, J. D. Swain, Philipp Papenbreer, Petr Travnicek, John Kelley, S. Mueller, R. Bilhaut, Alan Coleman, M. Roberts, L. Ochilo, Federico Suarez, L. Valore, Amin Aminaei, A. E. Herve, K. B. Barber, L. R. Wiencke, K. Weidenhaupt, C. O. Escobar, A. Insolia, M. Kleifges, D. Zavrtanik, Trent D. Grubb, D. Huber, L. Nellen, Juan Manuel Figueira, A. Dorofeev, M. Melissas, Peter Mazur, Thomas Hebbeker, Joshua A. Gordon, R. A. Vázquez, A. Schmidt, Sergio Dasso, Denis Tcherniakhovski, Roberta Colalillo, John N. Matthews, R. M. Kieckhafer, A. G. Mariazzi, Igor Katkov, M. Muenchmeyer, V. Novotny, A. F. Grillo, G. P. Guedes, Rossella Caruso, Toshihiro Fujii, G. Sequeiros, J. Rautenberg, A. Lucero, J. R. Hoerandel, F. Sanchez, O. Wainberg, Stefano Argiro, S. Mathys, C. Morello, K. D. de Vries, Matthias Balzer, J. A.J. Matthews, F. Schreuder, F. Sarazin, W. Fulgione, W. C. Brown, Patricia María Hansen, Richard Dallier, A. Nelles, M. Erfani, L. Molina-Bueno, D. Melo, H. Verkooijen, T. Pierog, Marco Giammarchi, T. Ohnuki, David Walz, V. Pirronello, J. F. Valdés Galicia, I. De Mitri, A. Gascon Bravo, Iuri Muniz Pepe, Jaime Alvarez-Muñiz, Pedro Assis, A. Etchegoyen, Esteban Roulet, R. Randriatoamanana, C. Jarne, A. Stutz, P. L. Ghia, J. N. Albert, M. Horvat, Marco Cilmo, Arnulfo Zepeda, Alberto Daniel Supanitsky, Lu Lu, R. Sato, Octavian Sima, J. G. Gonzalez, A. Tepe, Dariusz Gora, Peter L. Biermann, R. Mussa, J. J. Beatty, Manuel Platino, J. Grygar, M. A. Leigui de Oliveira, F. Schroeder, Jeffrey A. Johnsen, F. Werner, J. Knapp, J. R. Vázquez, D. Garcia-Gamez, S. Quinn, D. PakkSelmi-Dei, G. Matthiae, T. Rossler, A. Bridgeman, Antonio Bueno, A. Segreto, Günter Sigl, Silvia Mollerach, J. Coppens, Markus Roth, H. Dembinski, H. Vorenholt, I. A. Minaya, B. Keilhauer, E. Petermann, S. J. Saffi, T. Wijnen, P. Sanchez-Lucas, G. Garilli, D. Maurizio, D. Garcia-Pinto, M. Risse, Paolo Privitera, H. Hucker, J. Allen, André Schulz, P. Kasper, S. J. Sciutto, Radomir Smida, Kai Daumiller, G. Mueller, D. Heck, R. Meyhandan, V. Purrello, M. Josebachuili, J. C. Diaz, Alberto Filevich, F. Guarino, Lorenzo Caccianiga, V. M. Theodoro, S. Colonges, B. D. Fox, Markus Lauscher, B. Zamorano, J. Pouryamout, A. Ferrero, Julien Aublin, A. Shadkam, F. Bracci, Florian Gaté, G. Parente, J. Phuntsok, Raul Sarmento, Carlos Hojvat, O. Kroemer, S. J. De Jong, Marcio Aparecido Muller, Peter Buchholz, M. M. Freire, Jeffrey Brack, Olaf Scholten, T. N. Trung, Humberto Ibarguen Salazar, V. de Souza, A. Curutiu, S. Sánchez Navas, T. Asch, H. J. Mathes, Jose Chinellato, Gualberto Avila, Ingomar Allekotte, A. van Vliet, M. Szuba, Eric Mayotte, I.M. Brancus, B. Tome, C. De Donato, Miguel Mostafa, B. Wilczynska, M. Candusso, Peter Gorham, N.R. Wild, Alina Mihaela Badescu, D. Rogozin, J. de Oliveira, A. Widom, M. Gómez Berisso, N. Kunka, R. C. Shellard, Alejandro Almela, W. Docters, M. Oliveira, L. Tomankova, G. Navarra, B. Vlcek, A. López Casado, C. A. Moura, T. Yamamoto, Brian Fick, Ugo Giaccari, Charles Timmermans, J. Lozano Bahilo, Segev BenZvi, A. Letessier-Selvon, M. Prouza, A. Smialkowski, I. Al Samarai, L. Voyvodic, Sasa Micanovic, Angela V. Olinto, C. Di Giulio, Samo Stanič, H. M. Spinka, F. Montanet, M. Patel, L. Collica, J. Rodriguez Rojo, Marco Aglietta, Corbin Covault, Y. Petrov, C. D'Olivo, Lorenzo Cazon, P. Dolron, E. Tusi, A. G. Chavez, Enrique Zas, Lino Miramonti, M. D. Rodríguez-Frías, Iván Sidelnik, E.M. Holt, Fernando Contreras, Johannes Schumacher, A. Saleh, S. Harmsma, L. Perrone, Jiri Chudoba, S. Robbins, Michael Unger, S. Jansen, M. Fernandes, J. R. T. de Mello Neto, A. G. K. Smith, Maria-Teresa Dova, M. R. Hampel, R. Alves Batista, G. C. Hill, D. Torres Machado, Miroslav Pech, Colin Baus, Thomas Harrison, Ralph Engel, J. Ridky, N. Barenthien, Pavel Horvath, P. Pieroni, H. Schieler, Sarka Wykes, Karl-Heinz Kampert, Antonella Castellina, Heiko Geenen, C. Pryke, Jing Zhou, F. Arqueros, P. Necesal, M. S. Sutherland, R. Meissner, B. Vargas Cárdenas, S. van Velzen, K. H. Becker, N. Guardone, L. Guglielmi, M. Videla, J. Pallotta, K. Louedec, David Wittkowski, M. Urban, A. C. Rovero, Paula Gina Isar, C. Bleve, E. J. Quel, Pedro Brogueira, F. Salesa Greus, T. Bergmann, G. Cataldi, A. Filipcic, Azadeh Keivani, Béatrice Fuchs, Niraj Dhital, Octavian Fratu, W. Gotink, I. Valiño, D. Lebrun, U. Froehlich, G. Salina, Danielle LaHurd, Olivier Deligny, Nicolás González, W. Rodrigues de Carvalho, Sofia Andringa, J. W. Cronin, R. Speelman, P. van Bodegom, P. Lebrun, K. Gibbs, M. Palatka, A. Aab, E. Colombo, L. Caramete, M. I. Micheletti, Vincenzo Rizi, D. Martello, M. Ziolkowski, V. B. B. Mello, O. Martínez Bravo, J. Neuser, D. D'Urso, Corinne Berat, M. Giller, G. Toma, van den Ad M Berg, Luca Latronico, Nataliia Borodai, N. Scharf, P. Heimann, W. Tkaczyk, A. C. Fauth, Lukas Middendorf, H. Bolz, E. Trovato, Diego Harari, Christine Peters, A. Horneffer, P. Petrinca, Jose A. Bellido, B. Gookin, E. Kemp, J. Stasielak, S. Coutu, Norberto Fazzini, Serguei Vorobiov, P. H. Nguyen, A. Tapia, E. M. Santos, Balázs Kégl, Jaime Rosado, Mariangela Settimo, Alexey Yushkov, Max Malacari, Bruce R. Dawson, Tim Huege, G. Rodriguez Fernandez, Piotr Homola, Hernán Asorey, S. Le Coz, R. Cester, P. Facal San Luis, C. Porowski, O. A. Taborda, F. Schuessler, A. Cordier, H. Bluemer, I. C. Mariş, Hernan Wahlberg, Denise Boncioli, German Ros, R. R. Prado, Libor Nozka, Marcus Niechciol, E. D. Fraenkel, A. Parra, R. J. Lauer, P. Ristori, V. M. Olmos-Gilbaja, B. Courty, B. García, R. Pelayo, S. Querchfeld, R. López, Karen S. Caballero-Mora, A. Castera, L. Niemietz, B. Caccianiga, N. Pacheco, A. Porcelli, Tim Niggemann, M. Mallamaci, M. Ludwig, S. Hartmann, Martin Erdmann, G. Yuan, M. L. Díaz Castro, G. Farrar, G. Vitali, Francesca Zuccarello, Roger W Clay, Maurice Stephan, Johannes Schulz, M. Ave, J. Pouthas, M. Pimenta, P. Clark, A. Tonachini, C. Bonifaz, J. Baeuml, Tobias Winchen, M. Zimbres Silva, P.F. Gómez Vitale, J. Stapleton, Giovanni Marsella, D. Nosek, A. Weindl, N. Hollon, V. Verzi, David Schmidt, Paulo J. S. Gonçalves, T. Suomijaervi, I. Jandt, Ralf Ulrich, Paul M. Mantsch, R. Piegaia, M. Zavrtanik, A. Kaeaepae, N. Giudice, K. Arisaka, H. Glass, V. M. Aranda, Petr Schovanek, J. Kleinfeller, M. Barkhausen, Daniel Kuempel, S. Maldera, Ivone F. M. Albuquerque, Ke Fang, Darko Veberič, R. Bonino, Marc Weber, M. Buscemi, M. Hrabovsky, Jan Ebr, Sergio Petrera, H.O. Klages, S. Messina, A. P. Ferguson, G. Woerner, C. J. Todero Peixoto, C. H. Wiebusch, J. Maller, N. Krohm, B. Sarkar, Christian Glaser, J. Espadanal, H. Wilczyński, P. Billoir, L. del Peral, M. Avenier, N. Awal, D. Martraire, S. Grebe, R. Squartini, T. Paul, Olivier Ravel, E. Menichetti, G. Medina-Tanco, G. van Aar, K. Link, Research unit Astroparticle Physics, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Comisión Nacional de Energía Atómica, Fundación Antorchas, Gobierno De La Provincia de Mendoza, Municipalidad de Malargüe, NDM Holdings and Valle Las Leñas, in gratitude for their continuing cooperation over land access, Argentina, the Australian Research Council, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Financiadora de Estudos e Projetos (FINEP), Fundação de Amparo à Pesquisa do Estado de Rio de Janeiro (FAPERJ), São Paulo Research Foundation (FAPESP) Grants # 2010/07359-6 and # 1999/05404-3, Ministério de Ciência e Tecnologia (MCT), Brazil, MSMT-CRLG13007, 7AMB14AR005, CZ.1.05/2.1.00/03.0058 and the Czech Science Foundation Grant 14-17501S, Czech Republic, Centre de Calcul IN2P3/CNRS, Centre National de la Recherche Scientifique (CNRS), Conseil Régional Ile-de-France, Département Physique Nucléaire et Corpusculaire (PNC-IN2P3/CNRS), Département Sciences de l׳Univers (SDU-INSU/CNRS),Bundesministerium für Bildung und Forschung (BMBF), Deutsche Forschungsgemeinschaft (DFG), Finanzministerium Baden-Württemberg, Helmholtz Alliance for Astroparticle Physics (HAP), Helmholtz-Gemeinschaft Deutscher Forschungszentren (HGF), Ministerium für Wissenschaft und Forschung, Nordrhein Westfalen, Ministerium für Wissenschaft, Forschung und Kunst, Baden-Württemberg, Germany, Istituto Nazionale di Astrofisica (INAF), Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell׳Istruzione, dell׳Università e della Ricerca (MIUR), Gran Sasso Center for Astroparticle Physics (CFA), CETEMPS Center of Excellence, Italy, Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico, Ministerie van Onderwijs, Cultuur en Wetenschap, Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), Stichting voor Fundamenteel Onderzoek der Materie (FOM), Netherlands, National Centre for Research and Development, Grant nos. ERA-NET-ASPERA/01/11 and ERA-NET-ASPERA/02/11, National Science Centre, Grant nos. 2013/08/M/ST9/00322, and 2013/08/M/ST9/00728 and HARMONIA 5 – 2013/10/M/ST9/00062, Poland, Portuguese national funds and FEDER funds within COMPETE – Programa Operacional Factores de Competitividade through Fundação para a Ciencia e a Tecnologia, Portugal, Romanian Authority for Scientific Research ANCS, CNDI-UEFISCDI partnership projects nos. 20/2012 and nr.194/2012, project nos. 1/ASPERA2/2012 ERA-NET, PN-II-RU-PD-2011-3-0145-17, and PN-II-RU-PD-2011-3-0062, the Minister of National Education, Programme for research – Space Technology and Advanced Research – STAR, project number 83/2013, Romania, Slovenian Research Agency, Slovenia, Comunidad de Madrid, FEDER funds, Ministerio de Educación y Ciencia, Xunta de Galicia, Spain, Science and Technology Facilities Council, United Kingdom, Department of Energy, Contract no. DE-AC02-07CH11359, DE-FR02-04ER41300, DE-FG02-99ER41107 and DE-SC0011689, National Science Foundation, Grant no. 0450696, The Grainger Foundation, USA, NAFOSTED, Vietnam, Marie Curie-IRSES/EPLANET, European Particle Physics Latin American Network, European Union 7th Framework Program, Grant no. PIRSES-2009-GA-246806, and UNESCO., Pierre AUGER, ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), European Project: 328826,EC:FP7:PEOPLE,FP7-PEOPLE-2012-IEF,AUGER2FUTURE(2013), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Unité Scientifique de la Station de Nançay (USN), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Irish Agriculture and Food Development Authority, Fiocruz Minas - René Rachou Research Center / Instituto René Rachou [Belo Horizonte, Brésil], Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), STMicroelectronics [Crolles] (ST-CROLLES), Dipartimento de Ingenieria Quimica y Quimica Inorganica, Universidad de Cantabria [Santander], Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Istituto Nazionale di Fisica Nucleare, Sezione di Catania (INFN), Università degli studi di Catania [Catania], Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire d'aérologie (LAERO), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Al Samarai, I., Albert, J. N., Albuquerque, I. F. M., Allekotte, I., Allen, J., Allison, P., Almela, A., Alvarez Castillo, J., Alvarez Muñiz, J., Alves Batista, R., Ambrosio, M., Aminaei, A., Anchordoqui, L., Andringa, S., Aramo, C., Aranda, V. M., Argirò, S., Arisaka, K., Arneodo, F., Arqueros, F., Asch, T., Asorey, H., Assis, P., Aublin, J., Ave, M., Avenier, M., Avila, G., Awal, N., Badescu, A. M., Balzer, M., Barber, K. B., Barbosa, A., Barenthien, N., Bäuml, J., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Benzvi, S., Berat, C., Bergmann, T., Bertaina, M. E., Biermann, P. L., Bilhaut, R., Billoir, P., Blaess, S. G., Blanco, M., Bleve, C., Blümer, H., Boháčová, M., Bolz, H., Boncioli, D., Bonifazi, C., Bonino, R., Boratav, M., Borodai, N., Bracci, F., Brack, J., Brancus, I., Bridgeman, A., Brogueira, P., Brown, W. C., Buchholz, P., Bueno, A., Buitink, S., Buscemi, Mario, Caballero Mora, K. S., Caccianiga, B., Caccianiga, L., Camin, D., Candusso, M., Caramete, L., Caruso, R., Castellina, A., Castera, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chiosso, M., Chudoba, J., Cilmo, M., Clark, P. D. J., Clay, R. W., Cocciolo, G., Colalillo, Roberta, Coleman, A., Collica, L., Colombo, E., Colonges, S., Coluccia, M. R., Conceiçáo, R., Contreras, F., Cooper, M. J., Coppens, J., Cordier, A., Courty, B., Coutu, S., Covault, C. E., Cronin, J., Curutiu, A., Dallier, R., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., De Almeida, R. M., De Domenico, M., De Donato, C., De Jong, S. J., De Mello Neto, J. R. T., De Mitri, I., De Oliveira, J., De Souza, V., De Vries, K. D., Del Peral, L., Deligny, O., Dembinski, H., Dhital, N., Di Giulio, C., Di Matteo, A., Diaz, J. C., Díaz Castro, M. L., Diogo, F., Dobrigkeit, C., Docters, W., D'Olivo, J. C., Dolron, P., Dorofeev, A., Dorosti Hasankiadeh, Q., Dova, M. T., D'Urso, D., Ebr, J., Engel, R., Epele, L. N., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Facal San Luis, P., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Fernandes, M., Ferrero, A., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fox, B. D., Fraenkel, E. D., Fratu, O., Freire, M. M., Fröhlich, U., Fuchs, B., Fulgione, W., Fujii, T., García, B., Garcia Gamez, D., Garcia Pinto, D., Garilli, G., Gascon Bravo, A., Gate, F., Geenen, H., Gemmeke, H., Genolini, B., Ghia, P. L., Giaccari, U., Giammarchi, M., Gibbs, K., Giller, M., Giudice, N., Glass, H., Gómez Berisso, M., Gómez Vitale, P. F., Gonçalves, P., Gonzalez, J. G., González, N., Gookin, B., Góra, D., Gordon, J., Gorgi, A., Gorham, P., Gotink, W., Gouffon, P., Grebe, S., Griffith, N., Grillo, A. F., Grubb, T. D., Grygar, J., Guardone, N., Guarino, Fausto, Guedes, G. P., Guglielmi, L., Habraken, R., Hampel, M. R., Hansen, P., Harari, D., Harmsma, S., Harrison, T. 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A., Wittkowski, D., Yang, L., Zavrtanik, D., Physics, Elementary Particle Physics, Observatoire des Sciences de l'Univers en région Centre (OSUC), Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Università degli studi di Catania = University of Catania (Unict), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)
Subjects: detector [cosmic radiation], interaction [cosmic radiation], FLUORESCENCE YIELD, Physics - Instrumentation and Detectors, Air fluorescence detectors, hybrid observatory, Astronomy, Air fluorescence detector, Astrophysics, Auger, High energy cosmic ray, design [detector], Observatory, SURFACE DETECTOR ARRAY, High energy cosmic rays, Astrophysics::Solar and Stellar Astrophysics, fluorescence [air], Ultra-high-energy cosmic ray, ATMOSPHERIC MULTIPLE-SCATTERING, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Instrumentation, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, performance [detector], Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Pierre Auger Observatory, Instrumentation and Detectors (physics.ins-det), water Cherenkov detectors, LIGHT, Water Cherenkov detector, network [detector], LOWER IONOSPHERE, ddc:620, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Hybrid observatory, Water Cherenkov detectors, Nuclear and High Energy Physics, physics, air fluorescence detectors, Air fluorescence detectors, High energy cosmic rays, Hybrid observatory, Pierre Auger Observatory, Water Cherenkov detectors, Nuclear and High Energy Physics, Instrumentation, [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Cosmic ray, EXTENSIVE AIR-SHOWERS, Particle detector, VHE [cosmic radiation], ddc:530, RECONSTRUCTION, Cosmic-ray observatory, Instrumentation and Methods for Astrophysics (astro-ph.IM), Engineering & allied operations, Astrophysique, Ciencias Exactas, Nuclear and High Energy Physic, fluorescence [detector], high energy cosmic rays, Física, ASTROFÍSICA, ULTRA-HIGH ENERGY, Pierre Auger Observatory, High energy cosmic rays, Hybrid observatory, Water Cherenkov detectors, Air fluorescence detectors, Experimental High Energy Physics, RADIATION, EMISSION
Abstract: The successful installation, commissioning, and operation of the Pierre Auger Observatory would not have been possible without the strong commitment and effort from the technical and administrative staff in Malargüe. We are very grateful to the following agencies and organizations for financial support: Comisión Nacional de Energía Atómica, Fundación Antorchas, Gobierno De La Provincia de Mendoza, Municipalidad de Malargüe, NDM Holdings and Valle Las Leñas, in gratitude for their continuing cooperation over land access, Argentina; the Australian Research Council; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Financiadora de Estudos e Projetos (FINEP), Fundação de Amparo à Pesquisa do Estado de Rio de Janeiro (FAPERJ), São Paulo Research Foundation (FAPESP) Grants # 2010/07359-6 and # 1999/05404-3, Ministério de Ciência e Tecnologia (MCT), Brazil; MSMT-CR LG13007, 7AMB14AR005, CZ.1.05/2.1.00/03.0058 and the Czech Science Foundation Grant 14-17501S, Czech Republic; Centre de Calcul IN2P3/CNRS, Centre National de la Recherche Scientifique (CNRS), Conseil Régional Ile-de-France, Département Physique Nucléaire et Corpusculaire (PNC-IN2P3/CNRS), Département Sciences de l'Univers (SDU-INSU/CNRS), Institut Lagrange de Paris, ILP LABEX ANR-10-LABX-63, within the Investissements d'Avenir ProgrammeANR-11-IDEX-0004-02, France; Bundesministerium für Bildung und Forschung (BMBF), Deutsche Forschungsgemeinschaft (DFG), Finanzministerium Baden-Württemberg, Helmholtz Alliance for Astroparticle Physics (HAP), Helmholtz-Gemeinschaft Deutscher Forschungszentren (HGF), Ministerium für Wissenschaft und Forschung, Nordrhein Westfalen, Ministerium für Wissenschaft, Forschung und Kunst, Baden-Württemberg, Germany; Istituto Nazionale di Astrofisica (INAF), Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR), Gran Sasso Center for Astroparticle Physics (CFA), CETEMPS Center of Excellence, Italy; Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico; Ministerie van Onderwijs, Cultuur en Wetenschap, Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), Stichting voor Fundamenteel Onderzoek der Materie (FOM), Netherlands; National Centre for Research and Development, Grant nos. ERA-NETASPERA/01/11 and ERA-NET-ASPERA/02/11, National Science Centre, Grant nos. 2013/08/M/ST9/00322, and 2013/08/M/ST9/00728 and HARMONIA 5 – 2013/10/M/ST9/00062, Poland; Portuguese national funds and FEDER funds within COMPETE – Programa Operacional Factores de Competitividade through Fundação para a Ciencia e a Tecnologia, Portugal; Romanian Authority for Scientific Research ANCS, CNDI-UEFISCDI partnership projects nos. 20/2012 and nr.194/2012, project nos. 1/ASPERA2/2012 ERA-NET, PN-II-RU-PD-2011-3-0145-17, and PN-II-RU-PD-2011- 3-0062, the Minister of National Education, Programme for research – Space Technology and Advanced Research – STAR, project number 83/2013, Romania; Slovenian Research Agency, Slovenia; Comunidad de Madrid, FEDER funds, Ministerio de Educación y Ciencia, Xunta de Galicia, European Community 7th Framework Program, Grant no. FP7-PEOPLE-2012-IEF-328826, Spain; Science and Technology Facilities Council, United Kingdom; Department of Energy, Contract no. DE-AC02-07CH11359, DE-FR02-04ER41300, DE-FG02-99ER41107 and DE-SC0011689, National Science Foundation, Grant no. 0450696, The Grainger Foundation, USA; NAFOSTED, Vietnam; Marie Curie-IRSES/EPLANET, European Particle Physics Latin American Network, European Union 7th Framework Program, Grant no. PIRSES-2009- GA-246806; and UNESCO., The Pierre Auger Observatory, located on a vast, high plain in western Argentina, is the world׳s largest cosmic ray observatory. The objectives of the Observatory are to probe the origin and characteristics of cosmic rays above 1017 eV and to study the interactions of these, the most energetic particles observed in nature. The Auger design features an array of 1660 water Cherenkov particle detector stations spread over 3000 km2 overlooked by 24 air fluorescence telescopes. In addition, three high elevation fluorescence telescopes overlook a 23.5 km2, 61-detector infilled array with 750 m spacing. The Observatory has been in successful operation since completion in 2008 and has recorded data from an exposure exceeding 40,000 km2 sr yr. This paper describes the design and performance of the detectors, related subsystems and infrastructure that make up the Observatory., Comision Nacional de Energia Atomica, Fundacion Antorchas, Gobierno De La Provincia de Mendoza, Municipalidad de Malargue, NDM Holdings and Valle Las Lenas, Australian Research Council, National Council for Scientific and Technological Development (CNPq), Ciencia Tecnologia e Inovacao (FINEP), Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) 2010/07359-6 1999/05404-3, Ministerio de Ciencia e Tecnologia (MCT), Brazil, Ministry of Education, Youth & Sports - Czech Republic LG13007 7AMB14AR005 CZ.1.05/2.1.00/03.0058, Grant Agency of the Czech Republic Czech Republic Government 14-17501S, Centre National de la Recherche Scientifique (CNRS), Region Ile-de-France, Departement Physique Nucleaire et Corpusculaire PNC-IN2P3/CNRS, Departement Sciences de l'Univers (SDU-INSU/CNRS), Institut Lagrange de Paris, French National Research Agency (ANR) ANR-11-IDEX-0004-02 ANR-10-LABX-63, Federal Ministry of Education & Research (BMBF), German Research Foundation (DFG), Finanzministerium Baden-Wurttemberg, Helmholtz Alliance for Astroparticle Physics (HAP), Helmholtz Association, Ministerium fur Wissenschaft und Forschung, Nordrhein Westfalen, Ministerium fur Wissenschaft, Forschung und Kunst, Baden-Wurttemberg, Germany, Istituto Nazionale Astrofisica (INAF), Istituto Nazionale di Fisica Nucleare (INFN), Ministry of Education, Universities and Research (MIUR), Gran Sasso Center for Astroparticle Physics (CFA), CETEMPS Center of Excellence, Italy, Consejo Nacional de Ciencia y Tecnologia (CONACyT), Ministerie van Onderwijs, Cultuur en Wetenschap, Netherlands Organization for Scientific Research (NWO), FOM (The Netherlands) Netherlands Government, National Centre for Research and Development ERA-NET-ASPERA/01/11 ERA-NET-ASPERA/02/11, National Science Centre, Poland 2013/08/M/ST9/00322 2013/08/M/ST9/00728 HARMONIA 5 - 2013/10/M/ST9/00062, Portuguese national funds, FEDER funds within COMPETE - Programa Operacional Factores de Competitividade through Fundacao para a Ciencia e a Tecnologia, Portugal, Romanian Authority for Scientific Research ANCS, CNDI-UEFISCDI 20/2012 194/2012 1/ASPERA2/2012 ERA-NET PN-II-RU-PD-2011-3-0145-17 PN-II-RU-PD-2011-3-0062, Programme for research - Space Technology and Advanced Research - STAR, Romania 83/2013, Slovenian Research Agency - Slovenia, Comunidad de Madrid Instituto de Salud Carlos III, European Union (EU), Spanish Government, Xunta de Galicia, European Community, Spain FP7-PEOPLE-2012-IEF-328826, Science & Technology Facilities Council (STFC), United States Department of Energy (DOE) DE-AC02-07CH11359 DE-FR02-04ER41300 DE-FG02-99ER41107 DE-SC0011689, National Science Foundation (NSF) 0450696, Grainger Foundation, USA, National Foundation for Science & Technology Development (NAFOSTED), Marie Curie-IRSES/EPLANET, European Particle Physics Latin American Network, European Union (EU) PIRSES-2009-GA-246806, UNESCO
Published: 2015
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28. Searches for anisotropies in the arrival directions of the highest energy cosmic rays detected by the Pierre Auger Observatory

Author: Markus Risse, M. Urban, A. C. Rovero, C. Bleve, M. Oliveira, S. Riggi, Vincenzo Rizi, Toshihiro Fujii, Bruno Daniel, T. Yapici, Foteini Oikonomou, J. J. Masías Meza, D. Torres Machado, A. Shadkam, D. Maurel, M. Ziolkowski, O. Martínez Bravo, G. Matthiae, Johannes Schumacher, Iván Sidelnik, A. Cordier, Juan Carlos D'Olivo, T. Pierog, Esteban Roulet, P. Abreu, D. Ravignani, Paulo J. S. Gonçalves, A. Tapia, Paula Gina Isar, A. Chiavassa, Antonio Bueno, Pedro Brogueira, F. Salesa Greus, M. Josebachuili, A. E. Herve, K. B. Barber, H. Gemmeke, G. Cocciolo, A. Dorofeev, L. R. Wiencke, Yingchun Zhu, A. Tepe, Richard Dallier, A. Nelles, Jaime Alvarez-Muñiz, Lu Lu, F. Salamida, Luis A. Anchordoqui, B. Revenu, I. A. Minaya, B. Keilhauer, André Schulz, M. Ave, Gualberto Avila, Piera Luisa Ghia, Nicolás González, J. R. Vázquez, Ingomar Allekotte, Angela V. Olinto, Igor Katkov, R. Mussa, J. J. Beatty, D. Nitz, Silvia Mollerach, H. Dembinski, N. Fazzini, I. Jandt, L. Perrone, B. Kégl, Jose Chinellato, S. Quinn, A. Segreto, P. Sanchez-Lucas, D. Harari, Lorenzo Caccianiga, M. Platino, Alberto Filevich, Peter Hansen, P. Lautridou, M. Monasor, Ralf Ulrich, L. Martin, Marco Cilmo, F. Guarino, G. S. Varner, Peter Buchholz, V. M. Theodoro, S. Messina, A. Widom, K. Link, Paul M. Mantsch, M. Szuba, Miroslav Hrabovský, Julien Aublin, Paul Sommers, F. Werner, Stefan E. Müller, Alberto Daniel Supanitsky, U. Fröhlich, Lukas Middendorf, A. Letessier-Selvon, Radomir Smida, Corinne Berat, M. Giller, I.M. Brancus, T. Rossler, A. Bridgeman, H. Glass, P. Gouffon, Marco Aglietta, M. J. Cooper, Alina Mihaela Badescu, Eun-Joo Ahn, M. Prouza, F. Sánchez, Lorenzo Cazon, C. Aramo, A. Haungs, C. E. Santo, D. Martello, S. G. Blaess, Q. Dorosti Hasankiadeh, Markus Roth, Michael Unger, A. Śmiałkowski, François Montanet, S. van Velzen, E.M. Holt, A. Saleh, Maria-Teresa Dova, M. R. Hampel, R. Alves Batista, Carlos Medina, M. De Domenico, S. J. Saffi, M. Videla, B. Tome, G. Müller, B. Vlcek, Christine Peters, Martina Bohacova, Patrick Allison, Florian Gaté, V. de Souza, L. del Peral, C. J.W.P. Timmermans, N. Scharf, Sarka Wykes, L. Villase nor, P. Heimann, L. Molina-Bueno, D. Melo, Jing Zhou, R. Meissner, David Walz, David Wittkowski, Germano Guedes, L. Nožka, R. Piegaia, E. Petermann, Miroslav Pech, Guenter Sigl, Markus Lauscher, J. Phuntsok, Raul Sarmento, J. Sorokin, B. Mitrica, Z. Szadkowski, Danielle LaHurd, Olivier Deligny, Maria Rita Coluccia, Yogendra N. Srivastava, M. I. Micheletti, Pavel Horvath, O. Ravel, A. Di Matteo, N. Awal, B. Wundheiler, G. Cataldi, Peter Schiffer, Octavian Fratu, D. Pakk Selmi-Dei, Heino Falcke, R. Sato, J. Vicha, Jörg R. Hörandel, G. Garilli, A. Gorgi, V. M. Aranda, Gregory R Snow, L. Nellen, M. Blanco, M. Palatka, Serguei Vorobiov, D. Monnier Ragaigne, Rúben Conceição, G. Rodriguez Fernandez, C. Morello, I. Lhenry-Yvon, M. Ambrosio, V. Scherini, J. Allen, M. S. Sutherland, D. Maurizio, O. A. Taborda, Dusan Mandat, H. Martinez, A. van Vliet, Alexandra Saftoiu, Carola Dobrigkeit, M. Plum, B. Wilczynska, N. Palmieri, S. Navas, M. Melissas, Peter L. Biermann, P. H. Kasper, J. F. Valdés Galicia, Eric Mayotte, M. Gómez Berisso, R. C. Shellard, I. De Mitri, A. Gascon Bravo, A. Menshikov, Sofia Andringa, Dieter Heck, M. Mallamaci, W. Docters, Moritz Münchmeyer, M. Zavrtanik, Hernán Asorey, J. Rodriguez Rojo, Paolo Privitera, G. C. Hill, Joshua A. Gordon, R. A. Vázquez, A. Filipčič, J. D. Swain, Antonio Insolia, M. E. Bertaina, Alan Watson, G. Torralba Elipe, Eva Santos, V. Novotny, A. G. Chavez, Fred Sarazin, Mario Buscemi, Ralph Engel, Petr Schovanek, D. Garcia-Gamez, J. Alvarez Castillo, E. Varela, N. Griffith, K. Weidenhaupt, F.G. Schröder, R. Krause, Enrique Zas, I. M. Pepe, J. Ridky, F. Diogo, J. Bäuml, Rossella Caruso, A. Lucero, S. Petrera, O. Kambeitz, Marc Weber, M. Kleifges, D. Zavrtanik, L. Valore, Amin Aminaei, Peter Mazur, R. M. de Almeida, C. Di Giulio, A. Stutz, S. Mathys, M. Erfani, J. Pȩkala, Fernando Contreras, Harm Schoorlemmer, Octavian Sima, J. G. Gonzalez, S. J. De Jong, M. A. Leigui de Oliveira, J. Maller, Marco Giammarchi, Sergio Sciutto, I. Al Samarai, Stijn Buitink, Sasa Micanovic, D. Lebrun, Pierre Billoir, M. Avenier, L. Ochilo, A. Curutiu, Ugo Giaccari, D. Garcia-Pinto, Jeffrey Brack, Olaf Scholten, M. S. A. B. Leão, J. R. T. de Mello Neto, Humberto Ibarguen Salazar, B. Zamorano, V. Marin, Azadeh Keivani, W. Rodrigues de Carvalho, J. W. Cronin, P. van Bodegom, M. Candusso, G. Toma, John N. Matthews, R. M. Kieckhafer, Nataliia Borodai, J. Rautenberg, O. Wainberg, Peter Gorham, W. C. Brown, L. Collica, Jiri Chudoba, L. Tomankova, G. Navarra, Thomas Harrison, P. Pieroni, F. Arqueros, P. Necesal, C. A. Moura, T. Yamamoto, Brian Fick, Samo Stanič, Hermann-Josef Mathes, J. A.J. Matthews, Xavier Bertou, Kai Daumiller, A. Zepeda, R. Meyhandan, Pedro Assis, A. Etchegoyen, R. Gaior, F. Suarez, Thomas Hebbeker, Sergio Dasso, Martín Miguel Freire, J. Lozano Bahilo, D. Kruppke-Hansen, Corbin Covault, Y. Petrov, C. Jarne, E. Trovato, B. Gookin, P. H. Nguyen, I. C. Mariş, E. M. Santos, Hernan Wahlberg, Alexander Grillo, Lino Miramonti, Bruce R. Dawson, Tim Huege, R. R. Prado, Marcio Aparecido Muller, A. Parra, R. J. Lauer, P. Ristori, M. D. Rodríguez-Frías, B. Caccianiga, N. Kunka, Luca Latronico, A. C. Fauth, Carla Bonifazi, Jose A. Bellido, Jaime Rosado, R. Cester, B. Vargas Cárdenas, T. Suomijärvi, J. Pallotta, E. J. Quel, Béatrice Fuchs, Niraj Dhital, I. Valiño, B. D. Fox, J. Neuser, Philipp Papenbreer, J. S. Díaz, Petr Travnicek, G. Parente, Ernesto Kemp, Alan Coleman, Trent D. Grubb, D. Huber, Juan Manuel Figueira, Roberta Colalillo, A. G. Mariazzi, D. Rogozin, J. de Oliveira, Alejandro Almela, Miguel Mostafá, Alex Kääpä, Colin Baus, H. Schieler, M. Fernandes, Karl-Heinz Kampert, Antonella Castellina, K. Louedec, Mariangela Settimo, Alexey Yushkov, V. Purrello, H. Blümer, Max Malacari, Piotr Homola, P. Facal San Luis, S. Le Coz, C. L. Williams, O. Krömer, C. Hojvat, Jan Ebr, Johannes Schulz, H.O. Klages, K.-H. Becker, M. Pimenta, A. P. Ferguson, M. Zimbres Silva, Gaetano Salina, A.M. van den Berg, Darko Veberič, J. Stapleton, R. Bonino, B. García, Tobias Winchen, P. Lebrun, R. López, Karen S. Caballero-Mora, J. Kleinfeller, Daniel Kuempel, Carlos Escobar, M. Ludwig, S. Hartmann, S. Maldera, Ivone F. M. Albuquerque, Ke Fang, Martin Erdmann, Roger W Clay, D. Nosek, G. Marsella, Marcus Niechciol, A. Weindl, N. Hollon, V. Verzi, David Schmidt, M. L. Díaz Castro, G. Farrar, R. Pelayo, Francesca Zuccarello, S. Querchfeld, Maurice Stephan, A. Tonachini, L. Niemietz, P.F. Gómez Vitale, N. Pacheco, Tim Niggemann, A. Porcelli, A. Aab, L. Caramete, G. Yuan, J. Stasielak, S. Coutu, C. Porowski, Denise Boncioli, German Ros, Valerio Pirronello, C. J. Todero Peixoto, N. Krohm, B. Sarkar, Christian Glaser, J. Espadanal, H. Wilczyński, S. Grebe, R. Squartini, John L. Harton, T. Paul, G. Medina-Tanco, G. van Aar, S. Jansen, D. Martraire, Aab A., Abreu P., Aglietta M., Ahn E. J., Al Samarai I., Albuquerque I. F. M., Allekotte I., Allison P., Almela A., Alvarez Castillo J., Alvarez-Muñiz J., Alves Batista R., Ambrosio M., Aminaei A., Anchordoqui L., Andringa S., Aramo C., Aranda V. M., Arqueros F., Arsene N., Asorey H., Assis P., Aublin J., Ave M., Avenier M., Avila G., Awal N., Badescu A. M., Barber K. B., Bäuml J., Baus C., Beatty J. J., Becker K. H., Bellido J. A., Berat C., Bertaina M. E., Bertou X., Biermann P. L., Billoir P., Blaess S. G., Blanco A., Blanco M., Bleve C., Blümer H., Boháčová M., Boncioli D., Bonifazi C., Borodai N., Brack J., Brancus I., Bridgeman A., Brogueira P., Brown W. C., Buchholz P., Bueno A., Buitink S., Buscemi M., Caballero-Mora K. S., Caccianiga B., Caccianiga L., Candusso M., Caramete L., Caruso R., Castellina A., Cataldi G., Cazon L., Cester R., Chavez A. G., Chiavassa A., Chinellato J. A., Chudoba J., Cilmo M., Clay R. W., Cocciolo G., Colalillo R., Coleman A., Collica L., Coluccia M. R., Conceição R., Contreras F., Cooper M. J., Cordier A., Coutu S., Covault C. E., Cronin J., Dallier R., Daniel B., Dasso S., Daumiller K., Dawson B. R., de Almeida R. M., de Jong S. J., De Mauro G., de Mello Neto J. R. T., De Mitri I., de Oliveira J., de Souza V., del Peral L., Deligny O., Dembinski H., Dhital N., Di Giulio C., Di Matteo A., Diaz J. C., Díaz Castro M. L., Diogo F., Dobrigkeit C., Docters W., D’Olivo J. C., Dorofeev A., Dorosti Hasankiadeh Q., Dova M. T., Ebr J., Engel R., Erdmann M., Erfani M., Escobar C. O., Espadanal J., Etchegoyen A., Falcke H., Fang K., Farrar G., Fauth A. C., Fazzini N., Ferguson A. P., Fernandes M., Fick B., Figueira J. M., Filevich A., Filipčič A., Fox B. D., Fratu O., Freire M. M., Fuchs B., Fujii T., García B., Garcia-Pinto D., Gate F., Gemmeke H., Gherghel-Lascu A., Ghia P. L., Giaccari U., Giammarchi M., Giller M., Głas D., Glaser C., Glass H., Golup G., Gómez Berisso M., Gómez Vitale P. F., González N., Gookin B., Gordon J., Gorgi A., Gorham P., Gouffon P., Griffith N., Grillo A. F., Grubb T. D., Guardincerri Y., Guarino F., Guedes G. P., Hampel M. R., Hansen P., Harari D., Harrison T. A., Hartmann S., Harton J. L., Haungs A., Hebbeker T., Heck D., Heimann P., Herve A. E., Hill G. C., Hojvat C., Hollon N., Holt E., Homola P., Hörandel J. R., Horvath P., Hrabovský M., Huber D., Huege T., Insolia A., Isar P. G., Jandt I., Jansen S., Jarne C., Johnsen J. A., Josebachuili M., Kääpä A., Kambeitz O., Kampert K. H., Kasper P., Katkov I., Kégl B., Keilhauer B., Keivani A., Kemp E., Kieckhafer R. M., Klages H. O., Kleifges M., Kleinfeller J., Krause R., Krohm N., Krömer O., Kuempel D., Kunka N., LaHurd D., Latronico L., Lauer R., Lauscher M., Lautridou P., Le Coz S., Lebrun D., Lebrun P., Leigui de Oliveira M. A., Letessier-Selvon A., Lhenry-Yvon I., Link K., Lopes L., López R., López Casado A., Louedec K., Lu L., Lucero A., Malacari M., Maldera S., Mallamaci M., Maller J., Mandat D., Mantsch P., Mariazzi A. G., Marin V., Mariş I. C., Marsella G., Martello D., Martin L., Martinez H., Martínez Bravo O., Martraire D., Masías Meza J. J., Mathes H. J., Mathys S., Matthews J., Matthews J. A. J., Matthiae G., Maurel D., Maurizio D., Mayotte E., Mazur P. O., Medina C., Medina-Tanco G., Meissner R., Mello V. B. B., Melo D., Menshikov A., Messina S., Meyhandan R., Micheletti M. I., Middendorf L., Minaya I. A., Miramonti L., Mitrica B., Molina-Bueno L., Mollerach S., Montanet F., Morello C., Mostafá M., Moura C. A., Muller M. A., Müller G., Müller S., Mussa R., Navarra G., Navarro J. L., Navas S., Necesal P., Nellen L., Nelles A., Neuser J., Nguyen P. H., Niculescu-Oglinzanu M., Niechciol M., Niemietz L., Niggemann T., Nitz D., Nosek D., Novotny V., Nožka L., Ochilo L., Oikonomou F., Olinto A., Pacheco N., Pakk Selmi-Dei D., Palatka M., Pallotta J., Papenbreer P., Parente G., Parra A., Paul T., Pech M., Pȩkala J., Pelayo R., Pepe I. M., Perrone L., Petermann E., Peters C., Petrera S., Petrov Y., Phuntsok J., Piegaia R., Pierog T., Pieroni P., Pimenta M., Pirronello V., Platino M., Plum M., Porcelli A., Porowski C., Prado R. R., Privitera P., Prouza M., Purrello V., Quel E. J., Querchfeld S., Quinn S., Rautenberg J., Ravel O., Ravignani D., Revenu B., Ridky J., Riggi S., Risse M., Ristori P., Rizi V., Rodrigues de Carvalho W., Rodriguez Fernandez G., Rodriguez Rojo J., Rodríguez-Frías M. D., Rogozin D., Rosado J., Roth M., Roulet E., Rovero A. C., Saffi S. J., Saftoiu A., Salamida F., Salazar H., Saleh A., Salesa Greus F., Salina G., Sánchez F., Sanchez-Lucas P., Santos E., Santos E. M., Sarazin F., Sarkar B., Sarmento R., Sato R., Scarso C., Schauer M., Scherini V., Schieler H., Schiffer P., Schmidt D., Scholten O., Schoorlemmer H., Schovánek P., Schröder F. G., Schulz A., Schulz J., Schumacher J., Sciutto S. J., Segreto A., Settimo M., Shadkam A., Shellard R. C., Sidelnik I., Sigl G., Sima O., Śmiałkowski A., Šmída R., Snow G. R., Sommers P., Sorokin J., Squartini R., Srivastava Y. N., Stanca D., Stanič S., Stapleton J., Stasielak J., Stephan M., Stutz A., Suarez F., Suomijärvi T., Supanitsky A. D., Sutherland M. S., Swain J., Szadkowski Z., Taborda O. A., Tapia A., Tepe A., Theodoro V. M., Tiffenberg J., Timmermans C., Todero Peixoto C. J., Toma G., Tomankova L., Tomé B., Tonachini A., Torralba Elipe G., Torres Machado D., Travnicek P., Ulrich R., Unger M., Urban M., Valdés Galicia J. F., Valiño I., Valore L., van Aar G., van Bodegom P., van den Berg A. M., van Velzen S., van Vliet A., Varela E., Vargas Cárdenas B., Varner G., Vasquez R., Vázquez J. R., Vázquez R. A., Veberič D., Verzi V., Vicha J., Videla M., Villaseñor L., Vlcek B., Vorobiov S., Wahlberg H., Wainberg O., Walz D., Watson A. A., Weber M., Weidenhaupt K., Weindl A., Werner F., Widom A., Wiencke L., Wilczyński H., Winchen T., Wittkowski D., Wundheiler B., Wykes S., Yang L., Yapici T., Yushkov A., Zas E., Zavrtanik D., Zavrtanik M., Zepeda A., Zhu Y., Zimmermann B., Ziolkowski M., Zuccarello F., Research unit Astroparticle Physics, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Unité Scientifique de la Station de Nançay (USN), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de l'Accélérateur Linéaire (LAL), Pierre Auger, ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), European Project: 246806,EC:FP7:PEOPLE,FP7-PEOPLE-2009-IRSES,EPLANET(2011), European Project: 328826,EC:FP7:PEOPLE,FP7-PEOPLE-2012-IEF,AUGER2FUTURE(2013), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Observatoire des Sciences de l'Univers en région Centre (OSUC), Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Allen, J., Allison, P., Almela, A., Castillo, J. Alvarez, Alvarez Muniz, J., Batista, R. Alve, Ambrosio, M., Aminaei, A., Anchordoqui, L., Andringa, S., Aramo, C., Aranda, V. M., Arqueros, F., Asorey, H., Assis, P., Aublin, J., Ave, M., Avenier, M., Avila, G., Awal, N., Badescu, A. M., Barber, K. B., Bäuml, J., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Blaess, S. G., Blanco, M., Bleve, C., Blumer, H., Bohačova, M., Boncioli, D., Bonifazi, C., Bonino, R., Borodai, N., Brack, J., Brancus, I., Bridgeman, A., Brogueira, P., Brown, W. C., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero Mora, K. S., Caccianiga, B., Caccianiga, L., Candusso, M., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Cilmo, M., Clay, R. W., Cocciolo, G., Colalillo, Roberta, Coleman, A., Collica, L., Coluccia, M. R., Conceicao, R., Contreras, F., Cooper, M. J., Cordier, A., Coutu, S., Covault, C. E., Cronin, J., Curutiu, A., Dallier, R., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., Almeida, R. M. De, Domenico, M. De, Jong, S. J. De, De Mello Neto, J. R. T., Mitri, I. De, Oliveira, J. De, Souza, V. De, Peral, L. Del, Deligny, O., Dembinski, H., Dhital, N., Giulio, C. Di, Matteo, A. Di, Diaz, J. C., Castro, M. L. Diaz, Diogo, F., Dobrigkeit, C., Docters, W., D'Olivo, J. C., Dorofeev, A., Hasankiadeh, Q. Dorosti, Dova, M. T., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Luis, P. Facal San, Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Fernandes, M., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fox, B. D., Fratu, O., Freire, M. M., Frohlich, U., Fuchs, B., Fujii, T., Gaior, R., Garcia, B., Gamez, D. Garcia, Pinto, D. Garcia, Garilli, G., Bravo, A. Gascon, Gate, F., Gemmeke, H., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Glaser, C., Glass, H., Berisso, M. Gomez, Vitale, P. F. Gomez, Goncalves, P., Gonzalez, J. G., Gonzalez, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Grebe, S., Griffith, N., Grillo, A. F., Grubb, T. D., Guarino, Fausto, Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Hartmann, S., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Hollon, N., Holt, E., Homola, P., Horandel, J. R., Horvath, P., Hrabovsky, M., Huber, D., Huege, T., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Jarne, C., Josebachuili, M., Kaapa, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Kégl, B., Keilhauer, B., Keivani, A., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kromer, O., Hansen, D. Kruppke, Kuempel, D., Kunka, N., Lahurd, D., Latronico, L., Lauer, R., Lauscher, M., Lautridou, P., Coz, S. Le, Leao, M. S. A. B., Lebrun, D., Lebrun, P., Leigui De Oliveira, M. A., Letessier Selvon, A., Lhenry Yvon, I., Link, K., Lopez, R., Louedec, K., Bahilo, J. Lozano, Lu, L., Lucero, A., Ludwig, M., Malacari, M., Maldera, S., Mallamaci, M., Maller, J., Mandat, D., Mantsch, P., Mariazzi, A. G., Marin, V., Mariş, I. C., Marsella, G., Martello, D., Martin, L., Martinez, H., Bravo, O. Martinez, Martraire, D., Meza, J. J. Masia, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurel, D., Maurizio, D., Mayotte, E., Mazur, P. O., Medina, C., Tanco, G. Medina, Meissner, R., Melissas, M., Melo, D., Menshikov, A., Messina, S., Meyhandan, R., Mićanović, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Bueno, L. Molina, Mollerach, S., Monasor, M., Ragaigne, D. Monnier, Montanet, F., Morello, C., Mostafa, M., Moura, C. A., Muller, M. A., Muller, G., Muller, S., Munchmeyer, M., Mussa, R., Navarra, G., Navas, S., Necesal, P., Nellen, L., Nelles, A., Neuser, J., Nguyen, P. H., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Ochilo, L., Oikonomou, F., Olinto, A., Oliveira, M., Pacheco, N., Dei, D. Pakk Selmi, Palatka, M., Pallotta, J., Palmieri, N., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pkala, J., Pelayo, R., Pepe, I. M., Perrone, L., Petermann, E., Peters, C., Petrera, S., Petrov, Y., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porcelli, A., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Purrello, V., Quel, E. J., Querchfeld, S., Quinn, S., Rautenberg, J., Ravel, O., Ravignani, D., Revenu, B., Ridky, J., Riggi, S., Risse, M., Ristori, P., Rizi, V., Carvalho, W. Rodrigues De, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Frias, M. D. Rodriguez, Rogozin, D., Ros, G., Rosado, J., Rossler, T., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Sanchez, F., Lucas, P. Sanchez, Santo, C. E., Santos, E., Santos, E. M., Sarazin, F., Sarkar, B., Sarmento, R., Sato, R., Scharf, N., Scherini, V., Schieler, H., Schiffer, P., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovanek, P., Schroder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sidelnik, I., Sigl, G., Sima, O., ͆miałkowski, A., Šmada, R., Snow, G. R., Sommers, P., Sorokin, J., Squartini, R., Srivastava, Y. N., Stanič, S., Stapleton, J., Stasielak, J., Stephan, M., Stutz, A., Suarez, F., Suomijarvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Szuba, M., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Toma, G., Tomankova, L., Tomé, B., Tonachini, A., Elipe, G. Torralba, Machado, D. Torre, Travnicek, P., Trovato, E., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdé, Valino, I., Valore, Laura, Aar, G. Van, Bodegom, P. Van, Berg, A. M. Van Den, Velzen, S. Van, Vliet, A. Van, Varela, E., Cardenas, B. Varga, Varner, G., Vazquez, J. R., Vazquez, R. A., Veberič, D., Verzi, V., Vicha, J., Videla, M., Nor, L. Villase, Vlcek, B., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weidenhaupt, K., Weindl, A., Werner, F., Widom, A., Wiencke, L., Wilczyńska, B., Wilczyński, H., Williams, C., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yamamoto, T., Yapici, T., Yuan, G., Yushkov, A., Zamorano, B., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zhou, J., Zhu, Y., Silva, M. Zimbre, Ziolkowski, M., Zuccarello, F., Laboratoire de Physique Subatomique et de Cosmologie ( LPSC ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Unité Scientifique de la Station de Nançay ( USN ), Observatoire de Paris-Université d'Orléans ( UO ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire SUBATECH Nantes ( SUBATECH ), Mines Nantes ( Mines Nantes ) -Université de Nantes ( UN ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Physique Nucléaire d'Orsay ( IPNO ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de l'Accélérateur Linéaire ( LAL ), ANR-11-IDEX-0004-02/10-LABX-0063,ILP,Institute Lagrange of Paris ( 2011 ), European Project : 246806,EC:FP7:PEOPLE,FP7-PEOPLE-2009-IRSES,EPLANET ( 2011 ), European Project : 328826,EC:FP7:PEOPLE,FP7-PEOPLE-2012-IEF,AUGER2FUTURE ( 2013 ), UNIVERSIDADE DE ESTADUAL DE CAMPINAS, Physics, Elementary Particle Physics, Ahn, E. . J., Al Samarai, I., Albuquerque, I. . F. . M., Alvarez Castillo, J., Alvarez Muñiz, J., Alves Batista, R., Aranda, V. . M., Arsene, N., Badescu, A. . M., Barber, K. . B., Beatty, J. . J., Becker, K. . H., Bellido, J. . A., Bertaina, M. . E., Biermann, P. . L., Blaess, S. . G., Blanco, A., Bleve, Carla, Blümer, H., Boháčová, M., Brown, W. . C., Caballero Mora, K. . S., Chavez, A. . G., Chinellato, J. . A., Clay, R. . W., Colalillo, R., Coluccia, MARIA RITA, Conceição, R., Cooper, M. . J., Covault, C. . E., Dawson, B. . R., de Almeida, R. . M., de Jong, S. . J., De Mauro, G., de Mello Neto, J. . R. . T., DE MITRI, Ivan, de Oliveira, J., de Souza, V., del Peral, L., Di Giulio, C., Di Matteo, A., Diaz, J. . C., Díaz Castro, M. . L., D’Olivo, J. . C., Dorosti Hasankiadeh, Q., Dova, M. . T., Escobar, C. . O., Fauth, A. . C., Ferguson, A. . P., Figueira, J. . M., Fox, B. . D., Freire, M. . M., García, B., Garcia Pinto, D., Gherghel Lascu, A., Ghia, P. . 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J., Rodrigues de Carvalho, W., Rodriguez Fernandez, G., Rodriguez Rojo, J., Rodríguez Frías, M. . D., Rovero, A. . C., Saffi, S. . J., Salesa Greus, F., Sánchez, F., Sanchez Lucas, P., Santos, E. . M., Scarso, C., Schauer, M., Scherini, Viviana, Schovánek, P., Schröder, F. . G., Sciutto, S. . J., Shellard, R. . C., Śmiałkowski, A., Šmída, R., Snow, G. . R., Srivastava, Y. . N., Stanca, D., Suomijärvi, T., Supanitsky, A. . D., Sutherland, M. . S., Taborda, O. . A., Theodoro, V. . M., Tiffenberg, J., Todero Peixoto, C. . J., Torralba Elipe, G., Torres Machado, D., Valdés Galicia, J. . F., Valiño, I., Valore, L., van Aar, G., van Bodegom, P., van den Berg, A. . M., van Velzen, S., van Vliet, A., Vargas Cárdenas, B., Vasquez, R., Vázquez, J. . R., Vázquez, R. . A., Villaseñor, L., Watson, A. . A., Yang, L., and Zimmermann, B.
Subjects: acceleration of particles, astroparticle physics, Nuclear and High Energy Physics, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Upper Limit, Astronomy, Ciencias Físicas, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Field, Cosmic ray, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Otras Ciencias Físicas, 01 natural sciences, Settore FIS/04 - Fisica Nucleare e Subnucleare, Settore FIS/05 - Astronomia e Astrofisica, Observatory, Spectrum, 0103 physical sciences, acceleration of particles, astroparticle physics, Surface Detector, 010303 astronomy & astrophysics, acceleration of particle, Astrophysics::Galaxy Astrophysics, Physics, Pierre Auger Observatory, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, Settore FIS/01 - Fisica Sperimentale, Array, Astrophysics::Instrumentation and Methods for Astrophysics, [ PHYS.ASTR.HE ] Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], astroparticle physic, Astronomy and Astrophysics, ASTROFÍSICA, Nuclei, Space and Planetary Science, Experimental High Energy Physics, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Física nuclear, Catalog, Sky, Astrophysics - High Energy Astrophysical Phenomena, CIENCIAS NATURALES Y EXACTAS
Abstract: We analyze the distribution of arrival directions of ultra-high energy cosmic rays recorded at the Pierre Auger Observatory in 10 years of operation. The data set, about three times larger than that used in earlier studies, includes arrival directions with zenith angles up to $80^\circ$, thus covering from $-90^\circ$ to $+45^\circ$ in declination. After updating the fraction of events correlating with the active galactic nuclei (AGNs) in the V��ron-Cetty and V��ron catalog, we subject the arrival directions of the data with energies in excess of 40 EeV to different tests for anisotropy. We search for localized excess fluxes and for self-clustering of event directions at angular scales up to $30^\circ$ and for different threshold energies between 40~EeV and 80~EeV. We then look for correlations of cosmic rays with celestial structures both in the Galaxy (the Galactic Center and Galactic Plane) and in the local Universe (the Super-Galactic Plane). We also examine their correlation with different populations of nearby extragalactic objects: galaxies in the 2MRS catalog, AGNs detected by Swift-BAT, radio galaxies with jets and the Centaurus~A galaxy. None of the tests shows a statistically significant evidence of anisotropy. The strongest departures from isotropy (post-trial probability ${\sim}1.4$\%) are obtained for cosmic rays with $E>58$~EeV in rather large windows around Swift AGNs closer than 130~Mpc and brighter than $10^{44}$~erg/s (18$^\circ$ radius) and around the direction of Centaurus~A (15$^\circ$ radius)., Replaced with published version. Added Journal reference and DOI
Published: 2015
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29. The effect of the osmolality of sugar-containing media, the type of sugar, and the mass and molar concentration of sugar on the survival of frozen-thawed mouse sperm

Author: Peter Mazur and Chihiro Koshimoto
Subjects: Male, Sucrose, Molar concentration, Organ Preservation Solutions, Carbohydrates, General Biochemistry, Genetics and Molecular Biology, Osmolar Concentration, Mice, chemistry.chemical_compound, Cryoprotective Agents, Raffinose, Glycerol, Animals, Sugar, Cryopreservation, Chromatography, Dose-Response Relationship, Drug, Osmotic concentration, General Medicine, Spermatozoa, Sperm, Glucose, chemistry, General Agricultural and Biological Sciences, Semen Preservation
Abstract: Several factors have contributed to problems in mouse sperm cryopreservation, and we and others have found ways to ameliorate them. These include high sensitivity to several types of mechanical stresses and to oxygen-derived free radicals, low tolerance to osmotic cell volume changes, and rather rigorous requirements for cooling and warming rates. Another important factor is the cryoprotective agent. Mouse sperm are unusual in that our best results have been obtained in media containing the nonpermeating sugar raffinose (18% w/v) and lacking glycerol. This paper deals with questions about the basis of the protective action of sugars, and whether raffinose is unusual or unique in its ability to confer protection. More specifically, we investigated whether protection was more related to the total osmolality of the freezing solution, to the mass concentration of sugar, or to the molarity of the sugar, and we looked to see whether there are effects attributable to specific sugars. To investigate these questions, mouse sperm were frozen at the optimal rate of 25 degrees C/min in solutions prepared with different proportions of three sugars-raffinose, sucrose, and glucose-dissolved in 1/4x PBS. In the first experimental series, the total osmolality and the total sugar molarity were varied from 400 to 700 mOsm and from 300 to 530 mM, respectively, while holding the mass concentration of sugar constant at 18% (w/v). In the second experimental series, the mass concentration of sugars was varied from 10 to 18% while the sugar molarity and solution osmolality remained constant at 300 mM and 420 mOsm, respectively. The results suggest that protection against freezing and thawing depends more on the mass concentration of the sugar than on its molar concentration, a conclusion that has mechanistic implications.
Published: 2002
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30. Is Intracellular Ice Formation the Cause of Death of Mouse Sperm Frozen at High Cooling Rates?1

Author: Peter Mazur and Chihiro Koshimoto
Subjects: Nucleation, Cell Biology, General Medicine, Biology, medicine.disease, Sperm, Cryopreservation, Protoplasm, Reproductive Medicine, Congelation, Immunology, medicine, Biophysics, Dehydration, Supercooling, Intracellular
Abstract: Mouse spermatozoa in 18% raffinose and 3.8% Oxyrase in 0.25× PBS exhibit high motilities when frozen to −70°C at 20–130°C/min and then rapidly warmed. However, survival is
Published: 2002
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31. Effects of Cooling and Warming Rate to and from −70°C, and Effect of Further Cooling from −70 to −196°C on the Motility of Mouse Spermatozoa1

Author: Peter Mazur and Chihiro Koshimoto
Subjects: Osmole, In vitro fertilisation, medicine.medical_treatment, Motility, chemistry.chemical_element, Cell Biology, General Medicine, Anatomy, Biology, Sperm, Oxygen, Cryopreservation, Andrology, chemistry.chemical_compound, Reproductive Medicine, chemistry, Glycerol, medicine, Raffinose
Abstract: We have previously reported high survival in mouse sperm frozen at 21°C/min to −70°C in a solution containing 18% raffinose in 0.25× PBS (400 mOsm) and then warmed rapidly at approximately 2000°C/min, especially under lowered oxygen tensions induced by Oxyrase, a bacterial membrane preparation. The best survival rates were obtained in the absence of glycerol. The first concern of the present study was to determine the effects of the cooling rate on the survival of sperm suspended in this medium. The sperm were cooled to −70°C at rates ranging from 0.3 to 530°C/min. The survival curve was an inverted “U” shape, with the highest motility occurring between 27 and 130°C/min. Survival decreased precipitously at higher cooling rates. Decreasing the warming rate, however, decreased survivals at all cooling rates. The motility depression with slow warming was especially evident in sperm cooled at the optimal rates. This fact is consistent with our current view that the frozen medium surrounding sperm cel...
Published: 2002
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32. What are three actionable strategies to improve quality in biomedical research

Author: John G. Baust, John M. Baust, Jim Vaught, Glyn Stacey, Peter Mazur, Peter Riegman, Fay Betsou, Michael R. Barnes, and Albert E. Heacox
Subjects: Knowledge management, Computer science, business.industry, media_common.quotation_subject, Medicine (miscellaneous), Quality (business), Cell Biology, General Medicine, business, Data science, General Biochemistry, Genetics and Molecular Biology, media_common
Published: 2014

33. Comparison between the temperatures of intracellular ice formation in fresh mouse oocytes and embryos and those previously subjected to a vitrification procedure

Author: Shinsuke Seki and Peter Mazur
Subjects: Intracellular Fluid, Cryobiology, Biology, Article, Phase Transition, General Biochemistry, Genetics and Molecular Biology, Andrology, Mice, Cryoprotective Agents, Freezing, Congelation, Botany, medicine, Animals, Vitrification, Cryopreservation, Ice formation, Ice, Embryo, IIf, General Medicine, Embryo, Mammalian, Oocyte, Cold Temperature, medicine.anatomical_structure, embryonic structures, Oocytes, Female, General Agricultural and Biological Sciences, Intracellular
Abstract: When cells that have been subjected to supposedly innocuous freezing or vitrification procedures are used as the source material for subsequent experiments, it is important that they possess or exhibit the same relevant properties as fresh cells. In this study, we compared the temperatures of intracellular ice formation (IIF) in previously vitrified mouse oocytes/embryos with those in fresh intact ones. In the case of MII oocytes, 2-cell embryos, 4-6-cell embryos, and morulae, there are no significant differences (p0.05); namely, -33.3 degrees C (fresh) vs. -35.4 degrees C (vitrified) with MII oocytes, -40.6 degrees C (fresh) vs. -38.7 degrees C (vitrified) with 2-cell embryos, -38.0 degrees C (fresh) vs. -39.4 degrees C (vitrified) with 4-6-cell embryos, -24.5 degrees C (fresh) vs. -24.2 degrees C (vitrified) with morulae. But, in 8-cell embryos, there is a significant difference (p0.05) between fresh (-37.9 degrees C) and vitrified (-32.9 degrees C). If we include this significant difference, the overall IIF temperature of fresh cells is 0.74 degrees C lower than that of previously vitrified cells. If we exclude it, the IIF temperature for fresh cells is 0.32 degrees C higher than that for previously vitrified cells. Our conclusion then is that there is no difference between the IIF temperatures of fresh and previously vitrified cells.
Published: 2010
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34. Searches for Large-Scale Anisotropy in the Arrival Directions of Cosmic Rays Detected above Energy of $10^{19}$ eV at the Pierre Auger Observatory and the Telescope Array

Author: Telescope, Array, Pierre Auger Collaborations (Alexander Aab, Pedro, Abreu, Marco, Aglietta, Eun Joo Ahn, Imen Al Samarai, Ivone, Albuquerque, Ingomar, Allekotte, Jeff, Allen, Patrick, Allison, Alejandro, Almela, Jesus Alvarez Castillo, Jaime Alvarez Muñiz, Rafael Alves Batista, Michelangelo, Ambrosio, Amin, Aminaei, Luis, Anchordoqui, Sofia, Andringa, Carla, Aramo, Victor Manuel Aranda, Fernando, Arqueros, Hernán Gonzalo Asorey, Pedro, Assis, Julien, Aublin, Maximo, Ave, Michel, Avenier, Gualberto, Avila, Nafiun, Awal, Alina Mihaela Badescu, Barber, Kerri B., Julia, Bäuml, Colin, Baus, Jim, Beatty, Karl Heinz Becker, Bellido, Jose A., Corinne, Berat, Mario Edoardo Bertania, Xavier, Bertou, Peter, Biermann, Pierre, Billoir, Blaess, Simon G., Miguel, Blanco, Carla, Bleve, Hans, Blümer, Martina, Boháčová, Denise, Boncioli, Carla, Bonifazi, Raffaella, Bonino, Nataliia, Borodai, Jeffrey, Brack, Iliana, Brancus, Ariel, Bridgeman, Pedro, Brogueira, Brown, William C., Peter, Buchholz, Antonio, Bueno, Stijn, Buitink, Buscemi, Mario, Caballero Mora, Karen S., Barbara, Caccianiga, Lorenzo, Caccianiga, Marina, Candusso, Laurentiu, Caramete, Caruso, Rossella, Antonella, Castellina, Gabriella, Cataldi, Lorenzo, Cazon, Rosanna, Cester, Chavez, Alan G., Andrea, Chiavassa, Jose Augusto Chinellato, Jiri, Chudoba, Marco, Cilmo, Clay, Roger W., Giuseppe, Cocciolo, Roberta, Colalillo, Alan, Coleman, Laura, Collica, Maria Rita Coluccia, Ruben, Conceição, Fernando, Contreras, Cooper, Mathew J., Alain, Cordier, Stephane, Coutu, Corbin, Covault, James, Cronin, Alex, Curutiu, Richard, Dallier, Bruno, Daniel, Sergio, Dasso, Kai, Daumiller, Dawson, Bruce R., de Almeida, Rogerio M., Manlio De Domenico, de Jong, Sijbrand J., Joao de Mello Neto, Ivan De Mitri, Jaime de Oliveira, Vitor de Souza, Luis del Peral, Olivier, Deligny, Hans, Dembinski, Niraj, Dhital, Claudio Di Giulio, Armando Di Matteo, Johana Chirinos Diaz, Mary Lucia Díaz Castro, Francisco, Diogo, Carola, Dobrigkeit, Wendy, Docters, Juan Carlos D'Olivo, Alexei, Dorofeev, Qader Dorosti Hasankiadeh, Maria Teresa Dova, Jan, Ebr, Ralph, Engel, Martin, Erdmann, Mona, Erfani, Escobar, Carlos O., Joao, Espadanal, Alberto, Etchegoyen, Pedro Facal San Luis, Heino, Falcke, Fang, Ke, Glennys, Farrar, Anderson, Fauth, Norberto, Fazzini, Ferguson, Andrew P., Mateus, Fernandes, Brian, Fick, Juan Manuel Figueira, Alberto, Filevich, Andrej, Filipčič, Brendan, Fox, Octavian, Fratu, Uwe, Fröhlich, Benjamin, Fuchs, Toshihiro, Fujii, Romain, Gaior, Beatriz, García, Sayri Tupac Garcia Roca, Diego Garcia Gamez, Diego Garcia Pinto, Gianpaolo, Garilli, Alberto Gascon Bravo, Florian, Gate, Hartmut, Gemmeke, Piera Luisa Ghia, Ugo, Giaccari, Marco, Giammarchi, Maria, Giller, Christian, Glaser, Henry, Glass, Mariano Gómez Berisso, Gómez Vitale, Primo F., Patrícia, Gonçalves, Gonzalez, Javier G., Nicolás, González, Ben, Gookin, Jacob, Gordon, Alessio, Gorgi, Peter, Gorham, Philippe, Gouffon, Stefan, Grebe, Nathan, Griffith, Aurelio, Grillo, Grubb, Trent D., Fausto, Guarino, Germano, Guedes, Matías Rolf Hampel, Patricia, Hansen, Diego, Harari, Harrison, Thomas A., Sebastian, Hartmann, John, Harton, Andreas, Haungs, Thomas, Hebbeker, Dieter, Heck, Philipp, Heimann, Herve, Alexander E., Hill, Gary C., Carlos, Hojvat, Nicholas, Hollon, Ewa, Holt, Piotr, Homola, Jörg, Hörandel, Pavel, Horvath, Miroslav, Hrabovský, Daniel, Huber, Tim, Huege, Antonio, Insolia, Paula Gina Isar, Ingolf, Jandt, Stefan, Jansen, Cecilia, Jarne, Mariela, Josebachuili, Alex, Kääpä, Olga, Kambeitz, Karl Heinz Kampert, Peter, Kasper, Igor, Katkov, Balazs, Kégl, Bianca, Keilhauer, Azadeh, Keivani, Ernesto, Kemp, Roger, Kieckhafer, Hans, Klages, Matthias, Kleifges, Jonny, Kleinfeller, Raphael, Krause, Nicole, Krohm, Oliver, Krömer, Daniel Kruppke Hansen, Daniel, Kuempel, Norbert, Kunka, Danielle, Lahurd, Luca, Latronico, Robert, Lauer, Markus, Lauscher, Pascal, Lautridou, Sandra Le Coz, Milton, Leão, Didier, Lebrun, Paul, Lebrun, Marcelo Augusto Leigui de Oliveira, Antoine Letessier Selvon, Isabelle Lhenry Yvon, Katrin, Link, Rebeca, López, Angeles Lopez Agüera, Karim, Louedec, Julio Lozano Bahilo, Lu, Lu, Agustin, Lucero, Marianne, Ludwig, Max, Malacari, Simone, Maldera, Manuela, Mallamaci, Jennifer, Maller, Dusan, Mandat, Paul, Mantsch, Analisa, Mariazzi, Vincent, Marin, Ioana, Mariş, Giovanni, Marsella, Daniele, Martello, Lilian, Martin, Humberto, Martinez, Oscar Martínez Bravo, Diane, Martraire, Jimmy Masías Meza, Hermann Josef Mathes, Sebastian, Mathys, James, Matthews, John, Matthews, Giorgio, Matthiae, Detlef, Maurel, Daniela, Maurizio, Eric, Mayotte, Peter, Mazur, Carlos, Medina, Gustavo Medina Tanco, Rebecca, Meissner, Maximilien, Melissas, Diego, Melo, Alexander, Menshikov, Stefano, Messina, Rishi, Meyhandan, Saša, Mićanović, Maria Isabel Micheletti, Lukas, Middendorf, Minaya, Ignacio A., Lino, Miramonti, Bogdan, Mitrica, Laura Molina Bueno, Silvia, Mollerach, Maria, Monasor, Delphine Monnier Ragaigne, François, Montanet, Carlo, Morello, Miguel, Mostafá, Moura, Celio A., Marcio Aparecido Muller, Gero, Müller, Sarah, Müller, Moritz, Münchmeyer, Roberto, Mussa, Gianni, Navarra, Sergio, Navas, Petr, Necesal, Lukas, Nellen, Anna, Nelles, Jens, Neuser, Nguyen, Phong H., Marcus, Niechciol, Lukas, Niemietz, Tim, Niggemann, Dave, Nitz, Dalibor, Nosek, Vladimir, Novotny, Lyberis, Nožka, Livingstone, Ochilo, Angela, Olinto, Micael, Oliveira, Noelia, Pacheco, Daniel Pakk Selmi Dei, Miroslav, Palatka, Juan, Pallotta, Nunzia, Palmieri, Philipp, Papenbreer, Gonzalo, Parente, Alejandra, Parra, Thomas, Paul, Miroslav, Pech, Jan, Pękala, Rodrigo, Pelayo, Iuri, Pepe, Lorenzo, Perrone, Emily, Petermann, Christine, Peters, Sergio, Petrera, Yevgeniy, Petrov, Jamyang, Phuntsok, Ricardo, Piegaia, Tanguy, Pierog, Pablo, Pieroni, Mário, Pimenta, Valerio, Pirronello, Manuel, Platino, Matthias, Plum, Alessio, Porcelli, Czeslaw, Porowski, Raul Ribeiro Prado, Paolo, Privitera, Michael, Prouza, Victor, Purrello, Quel, Eduardo J., Sven, Querchfeld, Sean, Quinn, Julian, Rautenberg, Olivier, Ravel, Diego, Ravignani, Benoît, Revenu, Jan, Ridky, Simone, Riggi, Markus, Risse, Pablo, Ristori, Vincenzo, Rizi, Washington Rodrigues de Carvalho, Iago Rodriguez Cabo, Gonzalo Rodriguez Fernandez, Jorge Rubén Rodriguez Rojo, Maria Dolores Rodríguez Frías, Dmytro, Rogozin, Germán, Ros, Jaime, Rosado, Tomas, Rossler, Markus, Roth, Esteban, Roulet, Adrian, Rovero, Saffi, Steven J., Alexandra, Saftoiu, Francesco, Salamida, Humberto, Salazar, Ahmed, Saleh, Francisco Salesa Greus, Gaetano, Salina, Federico, Sánchez, Patricia Sanchez Lucas, Santo, Catarina E., Edivaldo Moura Santos, Eva, Santos, Fred, Sarazin, Biswaijt, Sarkar, Raul, Sarmento, Ricardo, Sato, Nils, Scharf, Viviana, Scherini, Harald, Schieler, Peter, Schiffer, David, Schmidt, Olaf, Scholten, Harm, Schoorlemmer, Petr, Schovánek, Alexander, Schulz, Johannes, Schulz, Johannes, Schumacher, Sergio, Sciutto, Alberto, Segreto, Mariangela, Settimo, Amir, Shadkam, Shellard, Ronald C., Iván, Sidelnik, Guenter, Sigl, Octavian, Sima, Andrzej, Śmiałkowski, Radomir, Šmída, Gregory, Snow, Paul, Sommers, Sorokin, J., Ruben, Squartini, Srivastava, Yogendra N., Samo, Stanič, James, Stapleton, Jaroslaw, Stasielak, Maurice, Stephan, Anne, Stutz, Federico, Suarez, Tiina, Suomijärvi, Daniel Supanitsky, A., Michael, Sutherland, John, Swain, Zbigniew, Szadkowski, Marek, Szuba, Oscar Alejandro Taborda, Alex, Tapia, Mathieu, Tartare, Andreas, Tepe, Vanessa Menezes Theodoro, Charles, Timmermans, Todero Peixoto, Carlos J., Gabriel, Toma, Lenka, Tomankova, Bernardo, Tomé, Aurelio, Tonachini, Guillermo Torralba Elipe, Diego Torres Machado, Petr, Travnicek, Enrica, Trovato, Matias, Tueros, Ralf, Ulrich, Michael, Unger, Martin, Urban, Valdés Galicia, Jose F., Ines, Valiño, Laura, Valore, Guus van Aar, Patrick van Bodegom, van den Berg, Ad M., Sjoert van Velzen, Arjen van Vliet, Enrique, Varela, Bernardo Vargas Cárdenas, Gary, Varner, Vázquez, Jose R., Ricardo, Vázquez, Darko, Veberič, Valerio, Verzi, Jakub, Vicha, Mariela, Videla, Luis, Villaseñor, Brian, Vlcek, Serguei, Vorobiov, Hernan, Wahlberg, Oscar, Wainberg, David, Walz, Alan, Watson, Marc, Weber, Klaus, Weidenhaupt, Andreas, Weindl, Felix, Werner, Allan, Widom, Lawrence, Wiencke, Barbara, Wilczyńska, Henryk, Wilczyński, Martin, Will, Christopher, Williams, Tobias, Winchen, David, Wittkowski, Brian, Wundheiler, Sarka, Wykes, Tokonatsu, Yamamoto, Tolga, Yapici, Guofeng, Yuan, Alexey, Yushkov, Bruno, Zamorano, Enrique, Zas, Danilo, Zavrtanik, Marko, Zavrtanik, Ingyin, Zaw, Arnulfo, Zepeda, Jing, Zhou, Yue, Zhu, Marcelo Zimbres Silva, Michael, Ziolkowski, Francesca, Zuccarello, Rasha, Abbasi, Michihiko, Abe, Tareq Abu Zayyad, Monica, Allen, Robyn, Anderson, Ryuji, Azuma, Elliott, Barcikowski, Belz, John W., Bergman, Douglas R., Samuel Adam Blake, Robert, Cady, Min Jung Chae, Byung Gu Cheon, Junsei, Chiba, Michiyuki, Chikawa, Woo Ram Cho, Masaki, Fukushima, Takashi, Goto, William, Hanlon, Yoshio, Hayashi, Naoaki, Hayashida, Kinya, Hibino, Ken, Honda, Daisuke, Ikeda, Naoya, Inoue, Takaaki, Ishii, Rie, Ishimori, Hideo Ito (Utah, U., Riken, Dmitri, Ivanov, Jui, Charles C. H., Kenichi, Kadota, Fumio, Kakimoto, Oleg, Kalashev, Katsuaki, Kasahara, Hideyuki, Kawai, Saburo, Kawakami, Shingo, Kawana, Kazumasa, Kawata, Eiji, Kido, Hang Bae Kim, Ji Hee Kim, Ji Hyun Kim, Seiji, Kitamura, Yuki, Kitamura, Vadim, Kuzmin, Young Joon Kwon, Jian, Lan, Sun In Lim, Jon Paul Lundquist, Kazuhiro, Machida, Kai, Martens, Takeshi, Matsuda, Toshio, Matsuyama, Matthews, John N., Mayuko, Minamino, Keijiro, Mukai, Isaac, Myers, Keisuke, Nagasawa, Shigehiro, Nagataki, Toru, Nakamura, Toshiyuki, Nonaka, Asuka, Nozato, Shoichi, Ogio, Jun, Ogura, Munehiro, Ohnishi, Hideyuki, Ohoka, Kaoru, Oki, Takeshi, Okuda, Masaomi, Ono, Akitoshi, Oshima, Shunsuke, Ozawa, Park, Il H., Pshirkov, Maxim S., Douglas Chase Rodriguez, Grigory, Rubtsov, Dongsu, Ryu, Hiroyuki, Sagawa, Nobuyuki, Sakurai, Sampson, Amanda L., Scott, Lauren M., Priti Dhanesh Shah, Fumiya, Shibata, Tatsunobu, Shibata, Hideaki, Shimodaira, Bok Kyun Shin, Smith, Jeremy D., Pierre, Sokolsky, Wayne Springer, R., Benjamin Taylor Stokes, Stratton, Sean R., Thomas, Stroman, Takumi, Suzawa, Mai, Takamura, Masahiro, Takeda, Ryuji, Takeishi, Akimichi, Taketa, Masato, Takita, Yuichiro, Tameda, Hideki, Tanaka, Koichi, Tanaka, Manobu, Tanaka, Thomas, Stanton B., Thomson, Gordon B., Peter, Tinyakov, Igor, Tkachev, Hisao, Tokuno, Takayuki, Tomida, Sergey, Troitsky, Yoshiki, Tsunesada, Kazuki, Tsutsumi, Yukio, Uchihori, Shigeharu, Udo, Federico, Urban, Gina, Vasiloff, Tiffany, Wong, Hiroshi, Yamaoka, Katsuya, Yamazaki, Jongmann, Yang, Kenta, Yashiro, Shigeru, Yoshida, Hisashi, Yoshii, Rhett, Zollinger, Zachary, Zundel, Shogo, Konishi, Shingo, Wachi, Yoshiki, Nishimoto, Heungsu, Shin, Mai, Tsujimoto, Tomoya, Matsuhira, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Unité Scientifique de la Station de Nançay (USN), Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), PIERRE AUGER, Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), A., Aab, P., Abreu, M., Aglietta, E. J., Ahn, I., Al Samarai, I. F. M., Albuquerque, I., Allekotte, J., Allen, P., Allison, A., Almela, J., Alvarez Castillo, J., Alvarez Mu?iz, R., Alves Batista, M., Ambrosio, A., Aminaei, L., Anchordoqui, S., Andringa, Aramo, Carla, F., Arquero, H., Asorey, P., Assi, J., Aublin, M., Ave, M., Avenier, G., Avila, A. M., Badescu, K. B., Barber, J., B?uml, C., Bau, J. J., Beatty, K. H., Becker, J. A., Bellido, C., Berat, M. E., Bertaina, X., Bertou, P. L., Biermann, P., Billoir, M., Blanco, C., Bleve, H., Bl?mer, M., Boh??ov?, D., Boncioli, C., Bonifazi, R., Bonino, N., Borodai, J., Brack, I., Brancu, P., Brogueira, W. C., Brown, P., Buchholz, A., Bueno, S., Buitink, Buscemi, Mario, K. S., Caballero Mora, B., Caccianiga, L., Caccianiga, M., Candusso, L., Caramete, R., Caruso, A., Castellina, G., Cataldi, L., Cazon, R., Cester, A. G., Chavez, A., Chiavassa, J. A., Chinellato, J., Chudoba, Cilmo, Marco, R. W., Clay, G., Cocciolo, Colalillo, Roberta, A., Coleman, L., Collica, M. R., Coluccia, R., Concei??o, F., Contrera, M. J., Cooper, A., Cordier, S., Coutu, C. E., Covault, J., Cronin, A., Curutiu, R., Dallier, B., Daniel, S., Dasso, K., Daumiller, B. R., Dawson, R. M., de Almeida, M., De Domenico, S. J., de Jong, J. R. T., de Mello Neto, I., De Mitri, J., de Oliveira, V., de Souza, L., del Peral, O., Deligny, H., Dembinski, N., Dhital, C., Di Giulio, A., Di Matteo, J. C., Diaz, M. L., D?az Castro, F., Diogo, C., Dobrigkeit, W., Docter, J. C., D'Olivo, A., Dorofeev, Q., Dorosti Hasankiadeh, M. T., Dova, J., Ebr, R., Engel, M., Erdmann, M., Erfani, C. O., Escobar, J., Espadanal, A., Etchegoyen, P., Facal San Lui, H., Falcke, K., Fang, G., Farrar, A. C., Fauth, N., Fazzini, A. P., Ferguson, M., Fernande, B., Fick, J. M., Figueira, A., Filevich, A., Filip?i?, B. D., Fox, O., Fratu, U., Fr?hlich, B., Fuch, T., Fuji, R., Gaior, B., Garc?a, S. T., Garcia Roca, D., Garcia Gamez, D., Garcia Pinto, G., Garilli, A., Gascon Bravo, F., Gate, H., Gemmeke, P. L., Ghia, U., Giaccari, M., Giammarchi, M., Giller, C., Glaser, H., Gla, M., G?mez Berisso, P. F., G?mez Vitale, P., Gon?alve, J. G., Gonzalez, N., Gonz?lez, B., Gookin, A., Gorgi, P., Gorham, P., Gouffon, S., Grebe, N., Griffith, A. F., Grillo, T. D., Grubb, Y., Guardincerri, Guarino, Fausto, G. P., Guede, M. R., Hampel, P., Hansen, D., Harari, T. A., Harrison, S., Hartmann, J. L., Harton, A., Haung, T., Hebbeker, D., Heck, P., Heimann, A. E., Herve, G. C., Hill, C., Hojvat, N., Hollon, E., Holt, P., Homola, J. R., H?randel, P., Horvath, M., Hrabovsk?, D., Huber, T., Huege, A., Insolia, P. G., Isar, K., Islo, I., Jandt, S., Jansen, C., Jarne, M., Josebachuili, A., K??p?, O., Kambeitz, K. H., Kampert, P., Kasper, I., Katkov, B., K?gl, B., Keilhauer, A., Keivani, E., Kemp, R. M., Kieckhafer, H. O., Klage, M., Kleifge, J., Kleinfeller, R., Krause, N., Krohm, O., Kr?mer, D., Kruppke Hansen, D., Kuempel, N., Kunka, G., La Rosa, D., Lahurd, L., Latronico, R., Lauer, M., Lauscher, P., Lautridou, S., Le Coz, M. S. A. B., Le?o, D., Lebrun, P., Lebrun, M. A., Leigui de Oliveira, A., Letessier Selvon, I., Lhenry Yvon, K., Link, R., L?pez, A., Lopez Ag?era, K., Louedec, J., Lozano Bahilo, L., Lu, A., Lucero, M., Ludwig, M. C., Maccarone, M., Malacari, S., Maldera, M., Mallamaci, J., Maller, D., Mandat, P., Mantsch, A. G., Mariazzi, V., Marin, I. C., Mari?, G., Marsella, D., Martello, L., Martin, H., Martinez, O., Mart?nez Bravo, D., Martraire, J. J., Mas?as Meza, H. J., Mathe, S., Mathy, J. A. J., Matthew, J., Matthew, G., Matthiae, D., Maurel, D., Maurizio, E., Mayotte, P. O., Mazur, C., Medina, G., Medina Tanco, M., Melissa, D., Melo, E., Menichetti, A., Menshikov, S., Messina, R., Meyhandan, S., Mi?anovi?, M. I., Micheletti, L., Middendorf, I. A., Minaya, L., Miramonti, B., Mitrica, L., Molina Bueno, S., Mollerach, M., Monasor, D., Monnier Ragaigne, F., Montanet, C., Morello, M., Mostaf?, C. A., Moura, M. A., Muller, G., M?ller, M., M?nchmeyer, R., Mussa, G., Navarra, S., Nava, P., Necesal, L., Nellen, A., Nelle, J., Neuser, M., Niechciol, L., Niemietz, T., Niggemann, D., Nitz, D., Nosek, V., Novotny, L., No?ka, L., Ochilo, A., Olinto, M., Oliveira, N., Pacheco, D., Pakk Selmi Dei, M., Palatka, J., Pallotta, N., Palmieri, P., Papenbreer, G., Parente, A., Parra, T., Paul, M., Pech, J., P?kala, R., Pelayo, I. M., Pepe, L., Perrone, R., Pesce, E., Petermann, C., Peter, S., Petrera, A., Petrolini, Y., Petrov, J., Phuntsok, R., Piegaia, T., Pierog, P., Pieroni, M., Pimenta, V., Pirronello, M., Platino, M., Plum, A., Porcelli, C., Porowski, R. R., Prado, P., Privitera, M., Prouza, V., Purrello, E. J., Quel, S., Querchfeld, S., Quinn, J., Rautenberg, O., Ravel, D., Ravignani, B., Revenu, J., Ridky, S., Riggi, M., Risse, P., Ristori, V., Rizi, J., Robert, W., Rodrigues de Carvalho, I., Rodriguez Cabo, G., Rodriguez Fernandez, J., Rodriguez Rojo, M. D., Rodr?guez Fr?a, G., Ro, J., Rosado, T., Rossler, M., Roth, E., Roulet, A. C., Rovero, S. J., Saffi, A., Saftoiu, F., Salamida, H., Salazar, A., Saleh, F., Salesa Greu, G., Salina, F., S?nchez, P., Sanchez Luca, C. E., Santo, E., Santo, E. M., Santo, F., Sarazin, B., Sarkar, R., Sarmento, R., Sato, N., Scharf, V., Scherini, H., Schieler, P., Schiffer, O., Scholten, H., Schoorlemmer, P., Schov?nek, A., Schulz, J., Schulz, J., Schumacher, S. J., Sciutto, A., Segreto, M., Settimo, A., Shadkam, R. C., Shellard, I., Sidelnik, G., Sigl, O., Sima, A., ?mia?kowski, R., ?m?da, G. R., Snow, P., Sommer, J., Sorokin, R., Squartini, Y. N., Srivastava, S., Stani?, J., Stapleton, J., Stasielak, M., Stephan, A., Stutz, F., Suarez, T., Suomij?rvi, A. D., Supanitsky, M. S., Sutherland, J., Swain, Z., Szadkowski, M., Szuba, O. A., Taborda, A., Tapia, M., Tartare, V. M., Theodoro, C., Timmerman, C. J., Todero Peixoto, G., Toma, L., Tomankova, B., Tom?, A., Tonachini, G., Torralba Elipe, D., Torres Machado, P., Travnicek, E., Trovato, M., Tuero, R., Ulrich, M., Unger, M., Urban, Galicia, J. F. Vald?s., I., Vali?o, Valore, Laura, G., van Aar, A. M., van den Berg, S., van Velzen, A., van Vliet, E., Varela, B., Vargas C?rdena, G., Varner, J. R., V?zquez, R. A., V?zquez, D., Veberi?, V., Verzi, J., Vicha, M., Videla, L., Villase?or, B., Vlcek, S., Vorobiov, H., Wahlberg, O., Wainberg, D., Walz, A. A., Watson, M., Weber, K., Weidenhaupt, A., Weindl, F., Werner, A., Widom, L., Wiencke, B., Wilczy?ska, H., Wilczy?ski, M., Will, C., William, T., Winchen, D., Wittkowski, B., Wundheiler, S., Wyke, T., Yamamoto, T., Yapici, P., Younk, G., Yuan, A., Yushkov, B., Zamorano, E., Za, D., Zavrtanik, M., Zavrtanik, I., Zaw, A., Zepeda, J., Zhou, Y., Zhu, M., Zimbres Silva, M., Ziolkowski, R. U., Abbasi, M., Abe, T., Abu Zayyad, M., Allen, R., Anderson, R., Azuma, E., Barcikowski, J. W., Belz, D. R., Bergman, S. A., Blake, R., Cady, M. J., Chae, B. G., Cheon, J., Chiba, M., Chikawa, W. R., Cho, T., Fujii, M., Fukushima, T., Goto, W., Hanlon, Y., Hayashi, N., Hayashida, K., Hibino, K., Honda, D., Ikeda, N., Inoue, T., Ishii, R., Ishimori, H., Ito, D., Ivanov, C. C. H., Jui, K., Kadota, F., Kakimoto, O., Kalashev, K., Kasahara, H., Kawai, S., Kawakami, S., Kawana, K., Kawata, E., Kido, H. B., Kim, J. H., Kim, S., Kitamura, Y., Kitamura, V., Kuzmin, Y. J., Kwon, J., Lan, S. I., Lim, J. 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B., Thomson, P., Tinyakov, I., Tkachev, H., Tokuno, T., Tomida, S., Troitsky, Y., Tsunesada, K., Tsutsumi, Y., Uchihori, S., Udo, F., Urban, G., Vasiloff, T., Wong, R., Yamane, H., Yamaoka, K., Yamazaki, J., Yang, K., Yashiro, Y., Yoneda, S., Yoshida, H., Yoshii, R., Zollinger, Z., Zundel, I. A., Samarai, I. F., M., J. A., Castillo, J., Alvarez Muñiz, R. A., Batista, C., Aramo, J., Bäuml, Bleve, Carla, H., Blümer, M., Boháčová, M., Buscemi, M., Cilmo, Cocciolo, Giuseppe, R., Colalillo, Coluccia, MARIA RITA, R., Conceição, R. M., De, M. D., Domenico, S. J., De, J. R., T., DE MITRI, Ivan, J. d., Oliveira, V. d., Souza, L. d., Peral, C. D., Giulio, A. D., Matteo, M. L., Díaz, Q. D., Hasankiadeh, P. F., San, A., Filipčič, U., Fröhlich, B., García, S. T., Garcia, A. G., Bravo, M. G., Berisso, P. F., Gómez, P., Gonçalve, N., González, F., Guarino, J. R., Hörandel, M., Hrabovský, A., Kääpä, B., Kégl, O., Krömer, G. L., Rosa, S. L., Coz, M. S., A., M. A., Leigui, R., López, A. L., Agüera, J. L., Bahilo, I. C., Mariş, Marsella, Giovanni, Martello, Daniele, O. M., Bravo, J. J., Masía, J. A., J., S., Mićanović, D. M., Ragaigne, M., Mostafá, G., Müller, M., Münchmeyer, L., Nožka, D. P., Selmi Dei, J., Pękala, Perrone, Lorenzo, W. R., De, I. R., Cabo, G. R., Fernandez, J. R., Rojo, M. D., Rodríguez Fría, F. S., Greu, F., Sánchez, Scherini, Viviana, P., Schovánek, A., Śmiałkowski, R., Šmída, S., Stanič, T., Suomijärvi, C. J., Todero, B., Tomé, G. T., Elipe, D. T., Machado, J. F., Valdé, I., Valiño, L., Valore, G. v., Aar, A. M., Van, S. v., Velzen, A. v., Vliet, B. V., Cárdena, J. R., Vázquez, R. A., Vázquez, D., Veberič, L., Villaseñor, B., Wilczyńska, H., Wilczyński, M. Z., Silva, T. P., Auger, C. C., H., T. T., Array, A. Aab, P. Abreu, M. Aglietta, E. J. Ahn, I. A. Samarai, I. F. M., I. Allekotte, J. Allen, P. Allison, A. Almela, J. A. Castillo, J. Alvarez-Muñiz, R. A. Batista, M. Ambrosio, A. Aminaei, L. Anchordoqui, S. Andringa, C. Aramo, F. Arquero, H. Asorey, P. Assi, J. Aublin, M. Ave, M. Avenier, G. Avila, A. M. Badescu, K. B. Barber, J. Bäuml, C. Bau, J. J. Beatty, K. H. Becker, J. A. Bellido, C. Berat, M. E. Bertaina, X. Bertou, P. L. Biermann, P. Billoir, M. Blanco, C. Bleve, H. Blümer, M. Boháčová, D. Boncioli, C. Bonifazi, R. Bonino, N. Borodai, J. Brack, I. Brancu, P. Brogueira, W. C. Brown, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, K. S. Caballero-Mora, B. Caccianiga, L. Caccianiga, M. Candusso, L. Caramete, R. Caruso, A. Castellina, G. Cataldi, L. Cazon, R. Cester, A. G. Chavez, A. Chiavassa, J. A. Chinellato, J. Chudoba, M. Cilmo, R. W. Clay, G. Cocciolo, R. Colalillo, A. Coleman, L. Collica, M. R. Coluccia, R. Conceição, F. Contrera, M. J. Cooper, A. Cordier, S. Coutu, C. E. Covault, J. Cronin, A. Curutiu, R. Dallier, B. Daniel, S. Dasso, K. Daumiller, B. R. Dawson, R. M. de, M. D. Domenico, S. J. de, J. R. T., I. D. Mitri, J. d. Oliveira, V. d. Souza, L. d. Peral, O. Deligny, H. Dembinski, N. Dhital, C. D. Giulio, A. D. Matteo, J. C. Diaz, M. L. Díaz, F. Diogo, C. Dobrigkeit, W. Docter, J. C. D'Olivo, A. Dorofeev, Q. D. Hasankiadeh, M. T. Dova, J. Ebr, R. Engel, M. Erdmann, M. Erfani, C. O. Escobar, J. Espadanal, A. Etchegoyen, P. F. San, H. Falcke, K. Fang, G. Farrar, A. C. Fauth, N. Fazzini, A. P. Ferguson, M. Fernande, B. Fick, J. M. Figueira, A. Filevich, A. Filipčič, B. D. Fox, O. Fratu, U. Fröhlich, B. Fuch, T. Fuji, R. Gaior, B. García, S. T. Garcia, D. Garcia-Gamez, D. Garcia-Pinto, G. Garilli, A. G. Bravo, F. Gate, H. Gemmeke, P. L. Ghia, U. Giaccari, M. Giammarchi, M. Giller, C. Glaser, H. Gla, M. G. Berisso, P. F. Gómez, P. Gonçalve, J. G. Gonzalez, N. González, B. Gookin, A. Gorgi, P. Gorham, P. Gouffon, S. Grebe, N. Griffith, A. F. Grillo, T. D. Grubb, Y. Guardincerri, F. Guarino, G. P. Guede, M. R. Hampel, P. Hansen, D. Harari, T. A. Harrison, S. Hartmann, J. L. Harton, A. Haung, T. Hebbeker, D. Heck, P. Heimann, A. E. Herve, G. C. Hill, C. Hojvat, N. Hollon, E. Holt, P. Homola, J. R. Hörandel, P. Horvath, M. Hrabovský, D. Huber, T. Huege, A. Insolia, P. G. Isar, K. Islo, I. Jandt, S. Jansen, C. Jarne, M. Josebachuili, A. Kääpä, O. Kambeitz, K. H. Kampert, P. Kasper, I. Katkov, B. Kégl, B. Keilhauer, A. Keivani, E. Kemp, R. M. Kieckhafer, H. O. Klage, M. Kleifge, J. Kleinfeller, R. Krause, N. Krohm, O. Krömer, D. Kruppke-Hansen, D. Kuempel, N. Kunka, G. L. Rosa, D. LaHurd, L. Latronico, R. Lauer, M. Lauscher, P. Lautridou, S. L. Coz, M. S. A., D. Lebrun, P. Lebrun, M. A. Leigui, A. Letessier-Selvon, I. Lhenry-Yvon, K. Link, R. López, A. L. Agüera, K. Louedec, J. L. Bahilo, L. Lu, A. Lucero, M. Ludwig, M. C. Maccarone, M. Malacari, S. Maldera, M. Mallamaci, J. Maller, D. Mandat, P. Mantsch, A. G. Mariazzi, V. Marin, I. C. Mariş, G. Marsella, D. Martello, L. Martin, H. Martinez, O. M. Bravo, D. Martraire, J. J. Masía, H. J. Mathe, S. Mathy, J. A. J., J. Matthew, G. Matthiae, D. Maurel, D. Maurizio, E. Mayotte, P. O. Mazur, C. Medina, G. Medina-Tanco, M. Melissa, D. Melo, E. Menichetti, A. Menshikov, S. Messina, R. Meyhandan, S. Mićanović, M. I. Micheletti, L. Middendorf, I. A. Minaya, L. Miramonti, B. Mitrica, L. Molina-Bueno, S. Mollerach, M. Monasor, D. M. Ragaigne, F. Montanet, C. Morello, M. Mostafá, C. A. Moura, M. A. Muller, G. Müller, M. Münchmeyer, R. Mussa, G. Navarra, S. Nava, P. Necesal, L. Nellen, A. Nelle, J. Neuser, M. Niechciol, L. Niemietz, T. Niggemann, D. Nitz, D. Nosek, V. Novotny, L. Nožka, L. Ochilo, A. Olinto, M. Oliveira, N. Pacheco, D. P. Selmi-Dei, M. Palatka, J. Pallotta, N. Palmieri, P. Papenbreer, G. Parente, A. Parra, T. Paul, M. Pech, J. Pękala, R. Pelayo, I. M. Pepe, L. Perrone, R. Pesce, E. Petermann, C. Peter, S. Petrera, A. Petrolini, Y. Petrov, J. Phuntsok, R. Piegaia, T. Pierog, P. Pieroni, M. Pimenta, V. Pirronello, M. Platino, M. Plum, A. Porcelli, C. Porowski, R. R. Prado, P. Privitera, M. Prouza, V. Purrello, E. J. Quel, S. Querchfeld, S. Quinn, J. Rautenberg, O. Ravel, D. Ravignani, B. Revenu, J. Ridky, S. Riggi, M. Risse, P. Ristori, V. Rizi, J. Robert, W. R. de, I. R. Cabo, G. R. Fernandez, J. R. Rojo, M. D. Rodríguez-Fría, G. Ro, J. Rosado, T. Rossler, M. Roth, E. Roulet, A. C. Rovero, S. J. Saffi, A. Saftoiu, F. Salamida, H. Salazar, A. Saleh, F. S. Greu, G. Salina, F. Sánchez, P. Sanchez-Luca, C. E. Santo, E. Santo, E. M. Santo, F. Sarazin, B. Sarkar, R. Sarmento, R. Sato, N. Scharf, V. Scherini, H. Schieler, P. Schiffer, O. Scholten, H. Schoorlemmer, P. Schovánek, A. Schulz, J. Schulz, J. Schumacher, S. J. Sciutto, A. Segreto, M. Settimo, A. Shadkam, R. C. Shellard, I. Sidelnik, G. Sigl, O. Sima, A. Śmiałkowski, R. Šmída, G. R. Snow, P. Sommer, J. Sorokin, R. Squartini, Y. N. Srivastava, S. Stanič, J. Stapleton, J. Stasielak, M. Stephan, A. Stutz, F. Suarez, T. Suomijärvi, A. D. Supanitsky, M. S. Sutherland, J. Swain, Z. Szadkowski, M. Szuba, O. A. Taborda, A. Tapia, M. Tartare, V. M. Theodoro, C. Timmerman, C. J. Todero, G. Toma, L. Tomankova, B. Tomé, A. Tonachini, G. T. Elipe, D. T. Machado, P. Travnicek, E. Trovato, M. Tuero, R. Ulrich, M. Unger, M. Urban, J. F. Valdé, I. Valiño, L. Valore, G. v. Aar, A. M. van, S. v. Velzen, A. v. Vliet, E. Varela, B. V. Cárdena, G. Varner, J. R. Vázquez, R. A. Vázquez, D. Veberič, V. Verzi, J. Vicha, M. Videla, L. Villaseñor, B. Vlcek, S. Vorobiov, H. Wahlberg, O. Wainberg, D. Walz, A. A. Watson, M. Weber, K. Weidenhaupt, A. Weindl, F. Werner, A. Widom, L. Wiencke, B. Wilczyńska, H. Wilczyński, M. Will, C. William, T. Winchen, D. Wittkowski, B. Wundheiler, S. Wyke, T. Yamamoto, T. Yapici, P. Younk, G. Yuan, A. Yushkov, B. Zamorano, E. Za, D. Zavrtanik, M. Zavrtanik, I. Zaw, A. Zepeda, J. Zhou, Y. Zhu, M. Z. Silva, M. Ziolkowski, T. P. Auger, R. U. Abbasi, M. Abe, T. Abu-Zayyad, M. Allen, R. Anderson, R. Azuma, E. Barcikowski, J. W. Belz, D. R. Bergman, S. A. Blake, R. Cady, M. J. Chae, B. G. Cheon, J. Chiba, M. Chikawa, W. R. Cho, T. Fujii, M. Fukushima, T. Goto, W. Hanlon, Y. Hayashi, N. Hayashida, K. Hibino, K. Honda, D. Ikeda, N. Inoue, T. Ishii, R. Ishimori, H. Ito, D. Ivanov, C. C. H., K. Kadota, F. Kakimoto, O. Kalashev, K. Kasahara, H. Kawai, S. Kawakami, S. Kawana, K. Kawata, E. Kido, H. B. Kim, J. H. Kim, S. Kitamura, Y. Kitamura, V. Kuzmin, Y. J. Kwon, J. Lan, S. I. Lim, J. P. Lundquist, K. Machida, K. Marten, T. Matsuda, T. Matsuyama, J. N. Matthew, M. Minamino, K. Mukai, I. Myer, K. Nagasawa, S. Nagataki, T. Nakamura, T. Nonaka, A. Nozato, S. Ogio, J. Ogura, M. Ohnishi, H. Ohoka, K. Oki, T. Okuda, M. Ono, A. Oshima, S. Ozawa, I. H. Park, M. S. Pshirkov, D. C. Rodriguez, G. Rubtsov, D. Ryu, H. Sagawa, N. Sakurai, A. L. Sampson, L. M. Scott, P. D. Shah, F. Shibata, T. Shibata, H. Shimodaira, B. K. Shin, J. D. Smith, P. Sokolsky, R. W. Springer, B. T. Stoke, S. R. Stratton, T. A. Stroman, T. Suzawa, M. Takamura, M. Takeda, R. Takeishi, A. Taketa, M. Takita, Y. Tameda, H. Tanaka, K. Tanaka, M. Tanaka, S. B. Thoma, G. B. Thomson, P. Tinyakov, I. Tkachev, H. Tokuno, T. Tomida, S. Troitsky, Y. Tsunesada, K. Tsutsumi, Y. Uchihori, S. Udo, F. Urban, G. Vasiloff, T. Wong, R. Yamane, H. Yamaoka, K. Yamazaki, J. Yang, K. Yashiro, Y. Yoneda, S. Yoshida, H. Yoshii, R. Zollinger, Z. Zundel, T. T. Array, and Research unit Astroparticle Physics
Subjects: Ciencias Físicas, Astronomy, Rays, Astrophysics, Astroparticle physics, Cosmic rays, 01 natural sciences, law.invention, Pierre, law, Anisotropy, Telescope, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, [PHYS]Physics [physics], Energy, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Astrophysics::Instrumentation and Methods for Astrophysics, astroparticle physic, Radiación cósmica, Auger, Cosmic, Arrival, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Física nuclear, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, CIENCIAS NATURALES Y EXACTAS, High, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Cosmic ray, SURFACE DETECTOR, ICECUBE, AIR-SHOWER ARRAY, Directions, cosmic rays, 0103 physical sciences, Instrumentation and Methods for Astrophysics (astro-ph.IM), Ciencias Exactas, Pierre Auger Observatory, SPECTRUM, 010308 nuclear & particles physics, Array, Spectral density, Spherical harmonics, Física, Astronomy and Astrophysics, ASTROFÍSICA, Ultra, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Astronomía, Dipole, RESOLUTION, Space and Planetary Science, Experimental High Energy Physics, Quadrupole, Observatory, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Spherical harmonic moments are well-suited for capturing anisotropy at any scale in the flux of cosmic rays. An unambiguous measurement of the full set of spherical harmonic coefficients requires full-sky coverage. This can be achieved by combining data from observatories located in both the northern and southern hemispheres. To this end, a joint analysis using data recorded at the Telescope Array and the Pierre Auger Observatory above 1019 eV is presented in this work. The resulting multipolar expansion of the flux of cosmic rays allows us to perform a series of anisotropy searches, and in particular to report on the angular power spectrum of cosmic rays above 1019 eV. No significant deviation from isotropic expectations is found throughout the analyses performed. Upper limits on the amplitudes of the dipole and quadrupole moments are derived as a function of the direction in the sky, varying between 7% and 13% for the dipole and between 7% and 10% for a symmetric quadrupole., Facultad de Ciencias Exactas
Published: 2014
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35. From Jews to New Christians

Author: Peter Mazur
Published: 2013
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36. âEl de los Catalanesâ

Author: Peter Mazur
Published: 2013
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37. Extreme rapid warming yields high functional survivals of vitrified 8-cell mouse embryos even when suspended in a half-strength vitrification solution and cooled at moderate rates to -196°C

Author: Peter Mazur, Bo Jin, and Shinsuke Seki
Subjects: Male, Osmosis, Time Factors, Cell Survival, Organ Preservation Solutions, Embryonic Development, Biology, General Biochemistry, Genetics and Molecular Biology, Article, Mice, Animal science, Animals, Vitrification, High rate, Cryopreservation, Ice formation, Embryo, General Medicine, Cooling rates, Anatomy, Embryo, Mammalian, embryonic structures, Female, General Agricultural and Biological Sciences, Warming rate
Abstract: To cryopreserve cells, it is essential to avoid intracellular ice formation during cooling and warming. One way to do so is to subject them to procedures that convert cell water into a non-crystalline glass. Current belief is that to achieve this vitrification, cells must be suspended in very high concentrations of glass-inducing solutes (i.e., ≥ 6 molal) and cooled at very high rates (i.e., >> 1,000°C/min). We report here that both these beliefs are incorrect with respect to the vitrification of 8-cell mouse embryos. In this study, precompaction 8-cell embryos were vitrified in several dilutions of EAFS10/10 using various cooling rates and warming rates. Survival was based on morphology, osmotic functionality, and on the ability to develop to expanded blastocysts. With a warming rate of 117,500°C/min, the percentages of embryos vitrified in 1×, 0.75×, and 0.5× EAFS that developed to blastocysts were 93%, 92%, and 86%, respectively. And the percentages of morphological survivors that developed to expanded blastocysts were 100%, 92%, and 97%, respectively. Even when the solute concentration of the EAFS was reduced to 33% of normal, we obtained 40% functional survival of these 8-cell embryos.
Published: 2013

38. The survival of mouse oocytes shows little or no correlation with the vitrification or freezing of the external medium, but the ability of the medium to vitrify is affected by its solute concentration and by the cooling rate

Author: Peter Mazur and Estefania Paredes
Subjects: Cell Survival, Evaporation rate, Thermodynamics, Biology, General Biochemistry, Genetics and Molecular Biology, Cryopreservation, Article, Mice, Cryoprotective Agents, Freezing, medicine, Animals, Vitrification, Dehydration, Droplet size, Cell survival, General Medicine, medicine.disease, Crystallography, Cooling rate, Oocytes, Female, General Agricultural and Biological Sciences, Warming rate
Abstract: As survival of mouse oocytes subjected to vitrification depends far more on the warming rate than on the cooling rate, we wished to determine whether the lack of correlation between survival and cooling rate was mirrored by a lack of correlation between cooling rate and vitrification of the medium (EAFS), and between survival and the vitrification of the medium. The morphological and functional survival of the oocytes showed little or no relation to whether or not the EAFS medium vitrified or froze. We studied if the droplet size and the elapsed time (between placing the droplet on the Cryotop and the start of cooling) affects the result through modification of the cooling rate and solute concentration. Dehydration was rapid; consequently, the time between the placing the droplets into a Cryotop and cooling must be held to a minimum. The size of the EAFS droplet that is being cooled does not seem to affect vitrification. Finally, the degree to which samples of EAFS vitrify is firmly dependent on both its solute concentration and the cooling rate.
Published: 2013

39. Osmotic Tolerance Limits and Properties of Murine Spermatozoa1

Author: Peter Mazur, A.T. Peter, John K. Critser, and Cara E. Willoughby
Subjects: Osmotic shock, Motility, Video microscopy, Cell Biology, General Medicine, Biology, Rhodamine 123, Sperm, Cryopreservation, chemistry.chemical_compound, Reproductive Medicine, chemistry, Immunology, Biophysics, Osmotic pressure, Propidium iodide
Abstract: Osmotic tolerance of spermatozoa is a critical determinant of functional survival after cryopreservation. This study first tested the hypothesis that mouse spermatozoa behave as linear osmometers, using an electronic particle counter to measure the change in sperm volume in response to anisosmotic solutions. The resulting Boyle-van't Hoff plot was linear (r 2 = 0.99) from 75 to 1200 mOsmolal and indicates that 60.7% of the total cell volume is osmotically inactive. Next, mouse sperm tolerance to osmotic stress was determined by assessment of plasma membrane integrity, mitochondrial viability, and motility. Each functional endpoint was measured after exposure to anisosmotic solutions and again after return to isosmolality. The dual fluorescent stains-carboxyfluorescein diacetate with propidium iodide and Rhodamine 123 with propidium iodide-were used to determine membrane integrity and functional mitochondria, respectively. Motility was measured by video microscopy in the range of 1-2400 mOsmolal and was further analyzed from 140 to 600 mOsmolal using computer-assisted semen analysis. The data indicate that motility is substantially more sensitive to osmotic stress than either mitochondrial viability or membrane integrity and that mouse spermatozoa should be maintained within 76-124% of their isosmotic volume during cryopreservation in order to maintain > 80% of pretreatment motility.
Published: 1996
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40. The Fermilab E771 spectrometer A large aperture spectrometer to study charm and beauty states as detected by decays into muons

Author: H.C. Ballagh, E. Gorini, C. R. Wang, S. Ramachandran, C. T. Murphy, Z. L. Cao, M. Panareo, C. Durandet, W. Selove, J. Lys, H. H. Bingham, M. He, J. Jennings, S. Misawa, Kwong Lau, Peter Mazur, T. Alexopoulos, P. Hanlet, J. Budagov, S. Conetti, P. Creti, K. S. Nelson, J. Trischuk, L. Antoniazzi, W. Yang, C. Wei, V. Elia, A. P. McManus, D. E. Wagoner, K. Hagan-Ingram, M. Jenkins, P. Torre, A. Boden, T. Lawry, R. P. Smith, M. Haire, V. Golovatyuk, Leonard Spiegel, C. Dukes, A. Blankman, S.N. Zhang, L. Fortney, W. Kononenko, G. Corti, E. Evangelista, G. Liguori, I. Tzamouranis, M. Recagni, D. Judd, A. Erwin, N. J. Zhang, F. Grancagnolo, J. Rhoades, Gianluca Introzzi, S.V. Borodin, Martin M. Block, Germano Bonomi, V. Pogosyan, T.Y. Chen, S. Tokar, N. Yao, G. H. Mo, Bradley Cox, G. Cataldi, M. Arenton, M. Cooper, David B. Cline, K. Clark, B. T. Zou, J. Segal, A. Ledovskoy, W. Kowald, L. Turnbull, J. G. Sun, T., Alexopoulo, L., Antoniazzi, M., Arenton, H. C., Ballagh, H., Bingham, A., Blankman, M., Block, A., Boden, G., Bonomi, S. V., Borodin, J., Budagov, Z. L., Cao, G., Cataldi, T. Y., Chen, K., Clark, D., Cline, S., Conetti, M., Cooper, G., Corti, B., Cox, P., Creti, C., Duke, C., Durandet, Elia, Valerio, A. R., Erwin, E., Evangelista, L., Fortney, V., Golovatyuk, Gorini, Edoardo, F., Grancagnolo, M., Haire, P., Hanlet, M., He, G., Introzzi, M., Jenkin, J., Jenning, D., Judd, W., Kononenko, W., Kowald, K., Lau, T., Lawry, A., Ledovskoy, G., Liguori, J., Ly, P. O., Mazur, A. P., Mcmanu, S., Misawa, G. H., Mo, C. T., Murphy, K., Nelson, Panareo, Marco, V., Pogosyan, S., Ramachandran, M., Recagni, J., Rhoade, J., Segal, W., Selove, R. P., Smith, L., Spiegel, J. G., Sun, S., Tokar, P., Torre, J., Trischuk, L., Turnbull, I., Tzamourani, D. E., Wagoner, C. R., Wang, C., Wei, W., Yang, N., Yao, N. J., Zhang, S. N., Zhang, and B. T., Zou
Subjects: Physics, GLASS ARRAY, Nuclear and High Energy Physics, Resistive touchscreen, Particle physics, Muon, Proton, Spectrometer, Physics::Instrumentation and Detectors, GEV POSITRONS, SHOWER, Large aperture, PERFORMANCE, RESISTIVE PLATE COUNTERS, Nuclear physics, RADIATION-DAMAGE, High mass, High Energy Physics::Experiment, Fermilab, Charm (quantum number), CALORIMETER, Nuclear Experiment, Instrumentation, SYSTEM, TRIGGER
Abstract: This paper describes the final incarnation of the Fermilab High Intensity Lab spectrometer which operated for ten years in the Proton West Area of Fermilab in the execution of two experiments (E537 and E705) which studied hadroproduction of high mass dimuon pairs. The version of the spectrometer used in E771 differed from earlier versions of the spectrometer by the addition of a silicon microstrip detector, pad chambers and resistive plate counters. These additions were implemented to give the spectrometer the capability of detection of secondary decay vertices from B --> mu or B --> J/psi --> mu mu decays. As discussed, the spectrometer in a short data taking period was able to address many kinds of physics, other than beauty decays.
Published: 1996
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41. The kinetics of embryo drying in Drosophila melanogaster as a function of the steps in permeabilization: Experimental

Author: Paul D. Schreuders, Anthony P. Mahowald, Peter Mazur, J.N. Kassis, Kenneth W. Cole, and U. Schneider
Subjects: Heptane, animal structures, Membrane permeability, Physiology, Butanol, Kinetics, Analytical chemistry, Biology, medicine.disease, chemistry.chemical_compound, Membrane, chemistry, Biochemistry, Permeability (electromagnetism), Insect Science, embryonic structures, medicine, Steady state (chemistry), Dehydration
Abstract: Previously, we gravimetrically examined the Drosophila embryos' rate of air drying after each step in their permeabilization; namely, (1) dechorionation, (2) isopropanol exposure, and (3) heptane/butanol exposure. Here we describe a physical model characterizing the dehydration and compare the theory with the experimental kinetics. The model is based on those of Eyring. It treats the net flux (Jnet) through the membrane as the sum of two opposing fluxes (air → embryo {a{ and embryo → air {i{. Each flux is the product of a kinetic constant (k), the number of embryos in the sample (n), and the water concentration (C). Thus, Jnet = kanCa −kinCi. The relationship between ki and ka, for embryos in steady state with room humidity, is kika = CaCi. Determining the k values requires the mass and density of the embryo solids, n, Ci, as a function of drying time, and the steady-state value of Ci. Following integration of the flux equation, linear regression was used to determine ki. ka was computed using the previous equation. The resulting values for ka are 3.96, 26.70, 17.40, and 258.00 mn3/embryo·h for untreated embryos and embryos treated with, (1), (l) + (2), (l) + (2) + (3), respectively. The corresponding values for ki (×106) are 484, 3680, 2800, and 47,300 mm3/embryo·h.
Published: 1996
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42. Permeabilization of Eggs of the Malaria MosquitoAnopheles gambiae

Author: Maria Del Pilar Valencia, Peter Mazur, and Louis H. Miller
Subjects: Ethylene Glycol, Cell Membrane Permeability, Bleach, Cryoprotectant, Sodium Hypochlorite, Anopheles gambiae, General Biochemistry, Genetics and Molecular Biology, Cryopreservation, chemistry.chemical_compound, Cryoprotective Agents, Anopheles, medicine, Animals, Humans, Dehydration, Ovum, Chromatography, biology, Isopropyl alcohol, General Medicine, biology.organism_classification, medicine.disease, Insect Vectors, Malaria, Drosophila melanogaster, chemistry, Evaluation Studies as Topic, Sodium hypochlorite, Ethylene Glycols, Female, General Agricultural and Biological Sciences, Ethylene glycol
Abstract: Although Anopheles gambiae embryos that have developed for 15 h at 17 degrees C are slightly permeable to water, they are impermeable to ethylene glycol, the cryoprotectant used in the cryopreservation of Drosophila melanogaster embryos. Success in cryopreservation requires that they be made permeable to protective solutes. Permeabilization of D. melanogaster was achieved by 1) dechorionation with 50% Clorox (household bleach) followed by 2) a water flush; 3) immersion in isopropyl alcohol to remove most extraembryonic water; 4) 2 min air drying to remove most isopropyl alcohol; 5) 90-s exposure to n-heptane containing 0.3% 1-butanol; and 6) 15-s exposure to pure n-heptane. The permeability of A. gambiae embryos was assessed by determining the times required for the initial dehydration of embryos in 1 M ethylene glycol in 260 mOsm Drosophila culture medium (permeability to water) and the times required for their return to normal volume (permeability to ethylene glycol). Based on these criteria, the above D. melanogaster procedure effectively permeabilizes 15 h/17 degrees C to 19 h/17 degrees C A. gambiae embryos. Nearly all collapsed in
Published: 1996
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43. Techniques for measuring aerosol attenuation using the Central Laser Facility at the Pierre Auger Observatory

Author: Miguel Mostafá, F. Diogo, E. Santos, R. M. de Almeida, M. Prouza, B. Zamorano Garcia, O. Tascau, Colin Baus, P. Abreu, D. Ravignani, Zbigniew Szadkowski, G. Cocciolo, G. Matthiae, S. Westerhoff, H. Schieler, Karl-Heinz Kampert, Antonio Bueno, Sergio Pastor, Antonella Castellina, J. Lozano Bahilo, Corbin Covault, Y. Petrov, M. Platino, M. Monasor, V. H. Ponce, Geraldina Golup, Alexander Grillo, S. Fliescher, E. Trovato, Diego Harari, Gualberto Avila, Ingomar Allekotte, C. E. Santo, Francisco J. Blanco, Lino Miramonti, N. Nierstenhoefer, B. Gookin, Jose Chinellato, F. Gomez Albarracin, Angela V. Olinto, S. Jansen, B. J. Whelan, M. Oliveira, J. Kleinfeller, E. M. Santos, S. H. Cheng, I. C. Mariş, Hernan Wahlberg, Bruce R. Dawson, P. Lautridou, B. Rouillé-D'Orfeuil, Martina Bohacova, Patrick Allison, A. Widom, S. J. De Jong, Leigui de Oliveira, H. Rivera, M. Straub, E. D. Fraenkel, J. Sorokin, Daniel Kuempel, R. J. Lauer, Yogendra N. Srivastava, Luis A. Anchordoqui, Pierre Billoir, A. F. Barbosa, Carlos Escobar, P. Ristori, D. Nosek, J. Knapp, A. Lopez Agüera, D. Thomas, A. Curutiu, M. Risse, Rémi Bardenet, M. Will, B. D. Fox, Alberto Filevich, G. Parente, Carlos Hojvat, J. C. Marin, H. R. Marquez Falcon, Alejandro Almela, Markus Ahlers, Yingchun Zhu, B. Revenu, Muller, S. Maldera, P. Brogueira, J. Oehlschläger, A. Letessier-Selvon, Petr Travnicek, M. Avenier, Peter Hansen, F. Guarino, Lorenzo Cazon, E. Varela, T. Rossler, Johannes Schulz, J. Maller, K.-H. Becker, Kai Daumiller, Peter Buchholz, Jörg R. Hörandel, G. Garilli, N. Griffith, S. J. Saffi, B. Caccianiga, L. Caramete, M. Plum, R. F. Gamarra, Trent D. Grubb, D. Huber, J. Bäuml, Rossella Caruso, A. Lucero, Ivone F. M. Albuquerque, Ke Fang, A. van Vliet, M. Szuba, F. Salesa Greus, P. Wahrlich, G. Marsella, Iván Sidelnik, N. T. Thao, Rúben Conceição, I.M. Brancus, R. Meyhandan, Eric Mayotte, M. Ave, G. La Rosa, R. E. Burton, B. Vargas Cárdenas, Alan Watson, M. Pimenta, Juan Manuel Figueira, Marco Aglietta, Roberta Colalillo, H. M. Spinka, A. G. Mariazzi, A. Weindl, Maria-Teresa Dova, H. Cook, J. Gitto, J. Alvarez Castillo, J. R. Vázquez, T. Suomijärvi, J. Pallotta, M. Gómez Berisso, Markus Lauscher, Jing Zhou, G. S. Varner, R. C. Shellard, K. Link, W. Docters, A. C. Rovero, I. Lhenry-Yvon, L. Perrone, Jiri Chudoba, D. Torres Machado, E. J. Quel, Kreso Kadija, D. Nitz, J. Stasielak, S. Coutu, D. Martraire, Béatrice Fuchs, Octavian Fratu, A. Gorgi, B. M. Baughman, A. Haungs, M. Zimbres Silva, J. L. Harton, M. Videla, Niraj Dhital, A. Smialkowski, N. Hollon, V. Verzi, Thomas Harrison, I. Valiño, A. Chiavassa, J. Espadanal, N. Palmieri, J. R. T. de Mello Neto, M. Palatka, M. Hrabovský, Norberto Fazzini, K. B. Barber, P. Pieroni, J. Neuser, D. Kruppke-Hansen, R. Gaior, J. Stapleton, G. Salina, Paul Sommers, P. Gouffon, Rodríguez-Frías, F. Arqueros, P. Necesal, L. R. Wiencke, M. L. Díaz Castro, G. Farrar, A. Menshikov, A.M. van den Berg, P. Karhan, A. Bellétoile, Olivier Deligny, C. E. Fracchiolla, D. D'Urso, P. Kasper, Alessandro Petrolini, A. Dorofeev, M. J. Cooper, Corinne Berat, Y. Guardincerri, P. T. Nhung, Darko Veberič, F. Sánchez, Luca Latronico, M. Coco, A. Keivani, Vincenzo Rizi, I. Rodriguez Cabo, F. Suarez, Thomas Hebbeker, Octavian Sima, J. G. Gonzalez, Sergio Dasso, M. De Domenico, A. Schmidt, R. Pesce, Igor Katkov, A. C. Fauth, K. Louedec, Mariangela Settimo, K. Weidenhaupt, Alexey Yushkov, Lukas Middendorf, V. C. Holmes, D. Lebrun, J. Schovancova, G. Torralba Elipe, D. Heck, V. Pirronello, G. Cataldi, D. Maurizio, Iuri Muniz Pepe, H. Lyberis, C. Jarne, R. Krause, W. Tkaczyk, Carla Bonifazi, D. Martello, G. Müller, Jose A. Bellido, L. Villaseñor, C. Rühle, E. Petermann, L. Valore, Peter Gorham, N. Kunka, H. Blümer, Max Malacari, Miroslav Pech, Peter Schiffer, V. Scherini, Amin Aminaei, L. Martin, M. Ziolkowski, C. Aramo, Alberto Daniel Supanitsky, U. Fröhlich, R. Bonino, T. Huege, Marco Cilmo, L. 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Krömer, A. Insolia, M. Kleifges, D. Zavrtanik, B. Tome, Peter Mazur, Ralph Engel, M. Blanco, J. Ridky, F.G. Schröder, Enrique Zas, H.O. Klages, A. Tonachini, B. García, Mario Scuderi, Tobias Winchen, T. Susa, A. Stutz, J. Pȩkala, L. Caccianiga, C. Di Giulio, Denise Boncioli, R. López, Karen S. Caballero-Mora, N. Scharf, Fernando Contreras, P. N. Dong, S. Messina, I. A. Minaya, B. Keilhauer, D. B. Tridapalli, J. Allen, S. Navas, M. Melissas, A. P. Ferguson, N. Krohm, A. Tapia, S. J. Sciutto, M. Ludwig, German Ros, Martin Erdmann, H. Gemmeke, M. Unger, R. A. Vázquez, G. Yuan, W. Rodrigues de Carvalho, B. Sarkar, Christian Glaser, F. Salamida, L. Molina-Bueno, D. Melo, M. Tartare, Roberts, F. Sarazin, J. W. Cronin, David Walz, Roger W Clay, Marc Weber, D. Pakk Selmi-Dei, P. Lebrun, G. Toma, E. Kemp, R. Sato, Nataliia Borodai, M. Ambrosio, F. Werner, H. Wilczyński, J. L. Navarro, D. Monnier Ragaigne, C. Pfendner, M. I. Micheletti, C. J.W.P. Timmermans, E. J. Ahn, H. Schoorlemmer, S. 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J., Whelan, A., Widom, G., Wieczorek, L., Wiencke, B., Wilczyńska, H., Wilczyński, M., Will, C., William, T., Winchen, M., Wommer, B., Wundheiler, T., Yamamoto a, T., Yapici, P., Younk, G., Yuan, A., Yushkov, B., Zamorano Garcia, E., Za, D., Zavrtanik, M., Zavrtanik, I., Zaw h, A., Zepeda b, J., Zhou, Y., Zhu, M., Zimbres Silva, M., Ziolkowski, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Unité Scientifique de la Station de Nançay (USN), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO), PIERRE AUGER, Aramo, Carla, Buscemi, Mario, Cilmo, Marco, Colalillo, Roberta, D., D’Urso, Guarino, Fausto, Valore, Laura, and The Pierre Auger, Collaboration
Subjects: Astronomy, Detector alignment and calibration methods (lasers, sources, particle-beams), 01 natural sciences, Detector alignment and calibration methods (laser, Observatory, ATMOSPHERIC CONDITIONS, Detector alignment and calibration methods, Instrumentation, cosmic ray, Mathematical Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, atmospheric monitoring, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Data analysi, particle-beams), ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Central Laser Facility, Física nuclear, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, sources, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], source, Auger Experiment, aerosols * Authors are listed on the following pages, Data analysis, FOS: Physical sciences, Cosmic ray, cosmic rays, aerosols, Optics, Ultra-high energy cosmic rays. atmospheric monitoring. aerosols, 0103 physical sciences, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Pierre Auger Observatory, 010308 nuclear & particles physics, business.industry, Large detector systems for particle and astroparticle physics, Attenuation, Atmospheric correction, Ultra-high energy cosmic rays, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Aerosol, Detector alignment and calibration methods (lasers, Air shower, detector alignment and calibration methods (lasers, large detector systems for particle and astroparticle physics, data analysis, Experimental High Energy Physics, Large detector systems for particle and astroparticle physic, business, RAIOS CÓSMICOS, SYSTEM
Abstract: The Pierre Auger Observatory in Malargue, Argentina, is designed to study the properties of ultra-high energy cosmic rays with energies above 10(18) eV. It is a hybrid facility that employs a Fluorescence Detector to perform nearly calorimetric measurements of Extensive Air Shower energies. To obtain reliable calorimetric information from the FD, the atmospheric conditions at the observatory need to be continuously monitored during data acquisition. In particular, light attenuation due to aerosols is an important atmospheric correction. The aerosol concentration is highly variable, so that the aerosol attenuation needs to be evaluated hourly. We use light from the Central Laser Facility, located near the center of the observatory site, having an optical signature comparable to that of the highest energy showers detected by the FD. This paper presents two procedures developed to retrieve the aerosol attenuation of fluorescence light from CLF laser shots. Cross checks between the two methods demonstrate that results from both analyses are compatible, and that the uncertainties are well understood. The measurements of the aerosol attenuation provided by the two procedures are currently used at the Pierre Auger Observatory to reconstruct air shower data., We are very grateful to the following agencies and organizations for financial support: Comision Nacional de Energia Atomica, Fundacion Antorchas, Gobierno De La Provincia de Mendoza, Municipalidad de Malargue, NDM Holdings and Valle Las Lenas, in gratitude for their continuing cooperation over land access, Argentina; the Australian Research Council; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Financiadora de Estudos e Projetos (FINEP), Fundacao de Amparo a Pesquisa do Estado de Rio de Janeiro (FAPERJ), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Ministerio de Ciencia e Tecnologia (MCT), Brazil; AVCR AV0Z10100502 and AV0Z10100522, GAAV KJB100100904, MSMT-CR LA08016, LC527, 1M06002, MEB111003, and MSM0021620859, Czech Republic; Centre de Calcul IN2P3/CNRS, Centre National de la Recherche Scientifique (CNRS), Conseil Regional Ile-de-France, Departement Physique Nucleaire et Corpusculaire (PNC-IN2P3/CNRS), Departement Sciences de l'Univers (SDU-INSU/CNRS), France; Bundesministerium fur Bildung und Forschung (BMBF), Deutsche Forschungsgemeinschaft (DFG), Finanzministerium Baden-Wurttemberg, Helmholtz-Gemeinschaft Deutscher Forschungszentren (HGF), Ministerium fur Wissenschaft und Forschung, Nordrhein-Westfalen, Ministerium fur Wissenschaft, Forschung und Kunst, Baden-Wurttemberg, Germany; Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR), Italy; Consejo Nacional de Ciencia y Tecnologia (CONACYT), Mexico; Ministerie van Onderwijs, Cultuur en Wetenschap, Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), Stichting voor Fundamenteel Onderzoek der Materie (FOM), Netherlands; Ministry of Science and Higher Education, Grant Nos. N N202 200239 and N N202 207238, Poland; Fundacao para a Ciencia e a Tecnologia, Portugal; Ministry for Higher Education, Science, and Technology, Slovenian Research Agency, Slovenia; Comunidad de Madrid, Consejeria de Educacion de la Comunidad de Castilla La Mancha, FEDER funds, Ministerio de Ciencia e Innovacion and Consolider-Ingenio 2010 (CPAN), Xunta de Galicia, Spain; Science and Technology Facilities Council, United Kingdom; Department of Energy, Contract Nos. DE-AC02-07CH11359, DE-FR02-04ER41300, National Science Foundation, Grant Nos. 0450696, 0855680, The Grainger Foundation USA; NAFOSTED, Vietnam; ALFA-EC /HE-LEN, European Union 6th Framework Program, Grant No. MEIF-CT-2005-025057, European Union 7th Framework Program, Grant No. PIEF-GA-2008-220240, and UNESCO.
Published: 2013
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44. Toward the cryopreservation of Zebrafish embryos: Tolerance to osmotic dehydration

Author: Estefania Paredes, Peter Mazur, Michelle H. Connolly, and Mary Hagedorn
Subjects: Chemistry, Zebrafish embryo, General Medicine, General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology, Cryopreservation, Osmotic dehydration, Cell biology
Published: 2016
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45. Andrology: Prevention of osmotic injury to human spermatozoa during addition and removal of glycerol*

Author: P.F. Watson, J. Liu, Frederick W. Kleinhans, Dayong Gao, Elizabeth S. Critser, John K. Critser, Peter Mazur, L. E. McGann, and Chi Liu
Subjects: endocrine system, Osmotic concentration, urogenital system, Rehabilitation, Obstetrics and Gynecology, Biology, Osmosis, Sperm, Reproductive Medicine, Cryoprotective Agent, Immunology, Biophysics, Osmotic pressure, Tonicity, Sperm motility, Sperm plasma membrane
Abstract: Use of a cryoprotective agent is indispensable to prevent injury to human spermatozoa during the cryopreservation process. However, addition of cryoprotective agents to spermatozoa before cooling and their removal after warming may create severe osmotic stress for the cells, resulting in injury. The objective of this study was to test the hypothesis that the degree (or magnitude) of human sperm volume excursion can be used as an independent indicator to evaluate and predict possible osmotic injury to spermatozoa during the addition and removal of cryoprotective agents. Glycerol was used as a model cryoprotective agent in the present study. To test this hypothesis, first the tolerance limits of spermatozoa to swelling in hypo-osmotic solutions (iso-osmotic medium diluted with water) and to shrinkage in hyperosmotic solutions (iso-osmotic medium with sucrose) were determined. Sperm plasma membrane integrity was measured by fluorescent staining, and sperm motility was assessed by computer-assisted semen analysis before, during and after the anisosomotic exposure. The result indicate firstly that motility was much more sensitive to anisosmotic conditions than membrane integrity, and secondly that motility was substantially more sensitive to hypotonic than to hypertonic conditions. Based on the experimental data, osmotic injury as a function of sperm volume excursion (swelling or shrinking) was determined. The second step, using these sperm volume excursion limits and previously measured glycerol and water permeability coefficients of human spermatozoa, was to predict, by computer simulation, the cell osmotic injury caused by different procedures for the addition and removal of glycerol. The predicted sperm injury was confirmed by experiment. Based on this study, an analytical methodology has been developed for predicting optimal protocols to reduce osmotic injury associated with the addition and removal of hypertonic concentrations of glycerol in human spermatozoa.
Published: 1995
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46. Regulatory volume decrease in COS-7 cells at 22 °C and its influence on the Boyle van’t Hoff relation and the determination of the osmotically inactive volume☆

Author: Diana B. Peckys and Peter Mazur
Subjects: Cryopreservation, Osmosis, COS cells, Chemistry, Cell volume, Osmolar Concentration, Thermodynamics, General Medicine, Haplorhini, Models, Biological, General Biochemistry, Genetics and Molecular Biology, Article, Cell size, Cell Physiological Phenomena, Kinetics, Membrane, Volume (thermodynamics), Isotonic, COS Cells, Animals, Least-Squares Analysis, General Agricultural and Biological Sciences, Cell Size
Abstract: Cryobiological analyses assume that the direction and rate of water movements across cell membranes and equilibrium cell volumes are determined solely by differences in the chemical potentials of intra- and extra-cellular water. A consequence of this assumption is that cells obey the Boyle van’t Hoff (BvH) law which states that cell volumes are a linear function of reciprocal osmolality. Extrapolation of the BvH plot to infinite osmolality yields a quantity b , the fractional volume of the cell occupied by solids. In many cells, however, a cell volume excursion above the isotonic volume initiates an energy-requiring response that causes the swollen cells to shrink back to or towards isotonic volume. It is referred to as regulatory volume decrease (RVD). We have observed a strong RVD in COS-7 cells. If not eliminated by keeping exposure times short, this RVD produces a b that is 60% too high (0.48 vs. 0.30). These results indicate the importance of examining cells for volume regulatory mechanisms before performing measurements to determine their osmotic parameters.
Published: 2012

47. Enhancements to the Southern Pierre Auger Observatory

Author: Giorgio Matthiae, E. Moreno, C. Macolino, Alessio Gorgi, J. Oehlschläger, S. Harmsma, M. Ave, R. Mussa, J. J. Beatty, Norbert Kunka, Silvia Mollerach, Alain Hervé, J. Coppens, Antonio Insolia, R. Sato, G. Müller, L. Winders, Richard Dallier, Christopher Morris, Jaime Alvarez-Muñiz, S. Dagoret-Campagne, Henry Glass, Eva Santos, C. Meurer, D. Pakk Selmi-Dei, D. Schuster, A. Anzalone, C. Morello, M. Prouza, Domenico Tegolo, A. Cordier, Antonio Bueno, M. Roth, N. Nierstenhoefer, R. D. Parsons, Luis Villaseñor, Dariusz Gora, Sergio Pastor, Diego Harari, B. Sarkar, R. Rebolo Lopez, Carola Dobrigkeit, Sergio Sciutto, P. Younk, Fabian Schmidt, J. K. Kulbartz, Daniel Gonzalez, Ricardo Vázquez, Jakub Vicha, P. A. Kasper, J. S. Díaz, P. Abreu, S. L. C. Barroso, M. Will, V. H. Ponce, T. Paul, B. Vargas Cárdenas, Miroslav Palatka, T. Yamamoto, Rémi Bardenet, Alexander Menshikov, D. Kruppke-Hansen, Simone Riggi, Ruben Squartini, Jiri Chudoba, Daniel Kuempel, D.R. Walz, A. Italiano, Sebastian Schulte, E. Strazzeri, E. Varela, N. T. Thao, T. Hebbeker, A. Shadkam, Peter Schiffer, K. B. Barber, A. Lemiere, I. Zaw, A. Creusot, Paolo Privitera, R.M. Kieckhafer, S. Maldera, P. Brogueira, M. Blanco, M. Zimbres-Silva, Mário Pimenta, Gregory R Snow, Moritz Münchmeyer, Christopher B. Williams, D. Maurizio, J. C. Moreno, Ralph Engel, E. Petermann, H. Schoorlemmer, A. Śmiał kowski, D. Allard, K. Gesterling, Mario Scuderi, Ivone F. M. Albuquerque, C. Aramo, Carlos Hojvat, Ernesto Kemp, H. H. Silva Lopez, Andreas Weindl, Dusan Mandat, M. Ambrosio, Niraj Dhital, I. Valiño, Katrin Link, E. Menichetti, Bruce R. Dawson, C. E. Santo, R. Bruijn, Petr Schovanek, Pham Ngoc Diep, C. Robledo, O. Wainberg, Jonny Kleinfeller, J. Alvarez Castillo, F. Sarazin, R. F. Gamarra, Karen S. Caballero-Mora, A. Stutz, H. R. Marquez Falcon, Gualberto Avila, Angela V. Olinto, C. Di Giulio, Michael Sutherland, A. Guzman, M. A. Muller, G. Marsella, A. Filevich, P. Gouffon, Gaetano Salina, U. Fröhlich, J. Bäuml, G. Yuan, P. Karhan, Bianca Keilhauer, M. Monasor, B. Zamorano, Sebastian Achim Mueller, M. Gold, J. D. Hague, L. Perrone, S. Westerhoff, Viviana Scherini, N. Palmieri, L. Anchordoqui, Alessandro Petrolini, K. Weidenhaupt, V. Verzi, P. Wahrlich, G. Sigl, L. Niemietz, A. Tamashiro, Heino Falcke, Paulo J. S. Gonçalves, J. Aublin, Miroslav Hrabovský, J. Lozano Bahilo, Segev BenZvi, Andreas Haungs, M. Videla, Michael Unger, A. Schmidt, Francisco J. Blanco, G. Cataldi, M. L. Díaz Castro, Jaroslaw Stasielak, Juan Carlos D'Olivo, L. del Peral, I. Fajardo Tapia, Hans Klages, A. Chiavassa, A. Nelles, M. T. Dova, Matthias Kleifges, H. Spinka, P. Ristori, S. H. Cheng, O. Ravel, Jan Ridky, V. Rizi, Corbin Covault, Roger W Clay, A. Ferrero, Azadeh Keivani, F. Gomez Albarracin, Esteban Roulet, Philipp Mertsch, Aaron S. Chou, Ricardo Piegaia, C. E. Fracchiolla, F. Arqueros, N. Krohm, V. M. Olmos-Gilbaja, P. Necesal, Germano Guedes, Hermann-Josef Mathes, G. Tristram, U. Cotti, Olivier Deligny, H. Salazar, Geraldina Golup, Alexander Grillo, Juan Pallotta, M. Tueros, Rodrigo Pelayo, P. Allison, Osvaldo Catalano, D. D'Urso, M. I. Micheletti, J. Rodriguez Martino, S. Fliescher, Corinne Berat, D. Nitz, D. García Gámez, Martina Bohacova, Miroslav Pech, Tobias Winchen, T. Bäcker, J. C. Marin, Hartmut Gemmeke, J. L. Harton, J. Petrovic, Xavier Bertou, Fausto Guarino, Jose Luis La Rosa Navarro, J. Pȩkala, H. Wahlberg, M. Zavrtnik, Javier Gonzalez, Piera Luisa Ghia, Darko Veberič, Diego Ravignani, Lino Miramonti, B. Rouillé-d'Orfeuil, P. T. Nhung, Anderson Fauth, S. Gambetta, Pedro Assis, K. Kadija, Adrian Rovero, J. R. Vázquez, O. Taşcău, J. R. T. de Mello Neto, Tiina Suomijarvi, K. D. de Vries, Jörg R. Hörandel, W. C. Brown, Ioana Codrina Maris, V. de Souza, K. Louedec, Mariangela Settimo, K. H. Kampert, Alexey Yushkov, J. F. Valdés Galicia, D. Monnier Ragaigne, P. L. Biermann, P. Buchholz, David Warner, Michael Ziolkowski, Javier Tiffenberg, I. De Mitri, H. Blümer, W. Rodrigues de Carvalho, Gonzalo Parente, J. Rosado, Benoît Revenu, S. Mićanović, D. Garcia-Pinto, Danilo Zavrtanik, M. S. A. B. Leão, Kumiko Kotera, Bryan C. Fuchs, Dieter Heck, Paul Sommers, R. Cester, A. Aminaei, A. F. Barbosa, Iván Sidelnik, W. Tkaczyk, B. J. Whelan, D. H. Koang, P. N. Dong, P. Lebrun, M. J. Cooper, Piotr Homola, P. Facal San Luis, M. Grigat, B. Morales, S. Jiraskova, M. Tartare, R. Gaior, C. Pfendner, J. W. Cronin, S. R. Gozzini, H. Martinez, Tim Huege, Dalibor Nosek, M. Josebachuili, J. Neuser, N. Hollon, E. Grashorn, F. Sánchez, Lawrence Wiencke, C. Timmermans D. K. Tiwari, H. Cook, M. De Domenico, Marcos Santander, C. O. Escobar, Valerio Pirronello, A.D. Supanitsky, A. Curutiu, J. A. J. Matthews, J. L. Kelley, Henryk Wilczyński, I. Allekotte, Sofia Andringa, R. Tcaciuc, J. D. Swain, Tanguy Pierog, Alan Watson, M. G. Winnick, F. Montanet, R. Bonino, A. Criss, Sergio Dasso, Zbigniew Szadkowski, M.D. Rodríguez-Frías, B. Wilczyńska, N. Pacheco, C. Jarne, Warner A. Miller, W. Docters, Paul Mantsch, Kurt Becker, G. Wieczorek, J. C. dos Anjos, E. Trovato, M. Gómez Berisso, P. Travnicek, E. J. Ahn, N. Griffith, Ernesto Arganda, Alejandra Parra, S. Sánchez Navas, Isabelle Lhenry-Yvon, M. Mostafá, N. Phan, Jose Chinellato, J. Chauvin, Edivaldo Moura Santos, J. Stapleton, M. Stephan, C. Lachaud, Peter Mazur, R. E. Burton, Y. Guardincerri, J. Knapp, A. Lopez Agüera, Maria J. Ortiz, H. Lyberis, D. Martello, Maria Rita Coluccia, Y. Petrov, M. C. Maccarone, P. Lautridou, M. Weber, N. Scharf, Carla Bonifazi, Alberto Segreto, Jose A. Bellido, A. Dorofeev, Iuri Muniz Pepe, A. Lucero, Peter Hansen, Nataliia Borodai, John Matthews, Jaroslava Schovancova, A. Letessier-Selvon, Maria Giller, Glennys R. Farrar, Jan Ebr, Arnulfo Zepeda, Etienne Parizot, L. Valore, J. Allen, Rossella Caruso, R. Pesce, Bruce Becker, J. Sorokin, T. Rossler, A. Bellétoile, Markus Risse, Galo Rafael Gonzalvo Rodriguez, Marianne Ludwig, Sergio Petrera, M. Melissas, G. La Rosa, F. Kuehn, H. Rivera, R. M. de Almeida, Rúben Conceição, Marco Aglietta, Lukas Nellen, M. Wommer, V. Marin, P. Billoir, S. Grebe, Sven Querchfeld, B. Gookin, M. Urban, C. Bleve, H. Dembinski, R. Ulrich, M.A. Leigui de Oliveira, C. J. Todero Peixoto, D. B. Tridapalli, P. Pieroni, L. Martin, A. Horneffer, P. Petrinca, Antonella Castellina, O. Martínez Bravo, M. Erdmann, V. C. Holmes, D. Lebrun, I. Dutan, I. Rodriguez-Cabo, B. M. Baughman, Julian Rautenberg, Radomir Smida, S. Coutu, Federico Suarez, A. Tonachini, L. Nožka, Lorenzo Cazon, G. De La Vega, A. M. van den Berg, Norberto Fazzini, Analisa Mariazzi, D. Melo, Kai Daumiller, Benjamin A. Garcia, M. Nyklicek, A. Filipčič, J. Rodriguez Rojo, L. Caramete, S. Stanič, Manuel Platino, C. De Donato, Jeffrey Brack, Olaf Scholten, M. Szuba, F.G. Schröder, Enrique Zas, Harald Schieler, A. Tapia, M. Balzer, C. Rühle, T. Yapici, M. Pontz, G. Decerprit, Alberto Etchegoyen, G. Navarra, A. P. Ferguson, C. A. Moura, Bernardo Tomé, Brian Fick, Brian Wundheiler, Fernando Contreras, Balázs Kégl, Subir Sarkar, A. Gascon, Hernán Asorey, T. Šuša, R.C. Shellard, Denise Boncioli, F. Ionita, S. J. De Jong, M. Avenier, D. Thomas, Ugo Giaccari, Francesco Salamida, German Ros, Gustavo Medina-Tanco, C. G. Tavera Ruiz, Eduardo Quel, E. D. Fraenkel, W. J. M. de Mello Junior, T. Antičić, J. Roberts, and O. Krömer
Subjects: History, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Astronomy, Cosmic ray, Scintillator, 01 natural sciences, 7. Clean energy, Education, Optics, Observatory, 0103 physical sciences, 010306 general physics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Cherenkov radiation, Physics, Pierre Auger Observatory, 010308 nuclear & particles physics, business.industry, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Computer Science Applications, Air shower, Experimental High Energy Physics, Amiga, business
Abstract: The southern Pierre Auger Observatory has been detecting cosmic rays above 1018eV since 2004, exploiting a hybrid air shower detection technique, with 1660 water Cherenkov detectors together with 24 air fluorescence telescopes on a 3000 km2 site. As low energy enhancements to the observatory, 3 additional telescopes with elevated fields of view were built (HEAT). The detector density was increased in the HEAT fields of view by a factor of four in an area of about 25 km2. This setup enables unbiased hybrid data taking above 1017eV. The infilled area is also being equipped with large underground scintillator muon detectors (AMIGA). Finally, a prototype array of radio antenna stations (AERA), working from 30 to 80 MHz, has been installed in a part of the infill. Properties and status of AMIGA, HEAT, and AERA are presented.
Published: 2012

48. Water volume and osmotic behaviour of mouse spermatozoa determined by electron paramagnetic resonance

Author: Jun Tao, Junying Du, Frederick W. Kleinhans, Peter Mazur, and John K. Critser
Subjects: Male, Embryology, Sodium, Analytical chemistry, Mineralogy, chemistry.chemical_element, Osmolar Concentration, law.invention, Mice, Endocrinology, law, Animals, Spin label, Electron paramagnetic resonance, Water content, Cryopreservation, Mice, Inbred ICR, Osmotic concentration, Chemistry, Cell Membrane, Electron Spin Resonance Spectroscopy, Water, Obstetrics and Gynecology, Cell Biology, Spermatozoa, Reproductive Medicine, Volume (thermodynamics), Water volume, Semen Preservation
Abstract: Experiments were conducted to determine the water volume and osmotic behaviour of mouse spermatozoa using an electron paramagnetic resonance technique using the spin label tempone, and the broadening agent potassium chromium oxalate. After a swim-up procedure, an average water volume of 43.3 micron3 of individual spermatozoa was obtained at 290 mosmol. If a water compartment of 59% is assumed, the total volume of mouse spermatozoa is 73.4 micron3. A plot of the relative water volume of mouse spermatozoa versus the reciprocal of buffer osmolality (Boyle van't Hoff plot) is linear in the range 250-900 mosmol of sodium chloride solutions (r2 = -.96). The Boyle van't Hoff plot intercept indicates that 13% of the spin-label accessible isotonic water is osmotically inactive.
Published: 1994
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49. The influence of human fertility on the economic conditions of the rural population in poland

Author: D. Peter Mazur
Subjects: Human fertility, education.field_of_study, History, business.industry, media_common.quotation_subject, Population, Fertility, Livelihood, Geography, Agriculture, Agricultural land, business, education, Rural population, Socioeconomic status, Demography, media_common
Abstract: Summary In 1970, Polish women in agricultural households reported larger numbers of children born alive than women in other occupations. When controlling for the influence of age at marriage and duration of marriage, the average number of children born per women among the farming population increased directly with the amount of privately owned agricultural land. Consistently, women whose principal source of livelihood was derived from non-agricultural sources even though they resided in villages, showed lower fertility than those in the agricultural sector, but significantly higher fertility than city women. This study is based on the five per cent sample of ever-married women between 15 and 70 years of age interviewed about their past reproductive histories in Poland during the 1970 Census of Population.The conclusions identify the high level of human fertility in rural populations as the main determinant of economic status among Polish peasants whose sources of support derive primarily from farming. Additional evidence supporting the hypothesis of dependence of the agricultural economy on the force of human reproduction is based on data for Slovakia and the Czech regions.
Published: 2011

50. Effect of the expression of aquaporins 1 and 3 in mouse oocytes and compacted eight-cell embryos on the nucleation temperature for intracellular ice formation

Author: Shinsuke Seki, Keisuke Edashige, Peter Mazur, and Sakiko Wada
Subjects: Embryology, Ethylene Glycol, Nucleation, Aquaporin, Biology, Morula, Cryopreservation, Article, Mice, Endocrinology, Cryoprotective Agents, Animals, RNA, Double-Stranded, Aquaporin 3, Mice, Inbred ICR, Ice crystals, Aquaporin 1, Cell Membrane, Ice, Temperature, Obstetrics and Gynecology, Gene Expression Regulation, Developmental, IIf, Cell Biology, Hydrogen-Ion Concentration, Embryo, Mammalian, Membrane, Reproductive Medicine, Biochemistry, Models, Animal, Ice nucleus, Biophysics, Oocytes, Female, Crystallization, Intracellular
Abstract: The occurrence of intracellular ice formation (IIF) is the most important factor determining whether cells survive a cryopreservation procedure. What is not clear is the mechanism or route by which an external ice crystal can traverse the plasma membrane and cause the heterogeneous nucleation of the supercooled solution within the cell. We have hypothesized that one route is through preexisting pores in aquaporin (AQP) proteins that span the plasma membranes of many cell types. Since the plasma membrane of mature mouse oocytes expresses little AQP, we compared the ice nucleation temperature of native oocytes with that of oocytes induced to express AQP1 and AQP3. The oocytes were suspended in 1.0 M ethylene glycol in PBS for 15 min, cooled in a Linkam cryostage to −7.0 °C, induced to freeze externally, and finally cooled at 20 °C/min to −70 °C. IIF that occurred during the 20 °C/min cooling is manifested by abrupt black flashing. The mean IIF temperatures for native oocytes, for oocytes sham injected with water, for oocytes expressing AQP1, and for those expressing AQP3 were −34, −40, −35, and −25 °C respectively. The fact that the ice nucleation temperature of oocytes expressing AQP3 was 10–15 °C higher than the others is consistent with our hypothesis. AQP3 pores can supposedly be closed by low pH or by treatment with double-strandedAqp3RNA. However, when morulae were subjected to such treatments, the IIF temperature still remained high. A possible explanation is suggested.
Published: 2011

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