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1. COLOR: A Randomized Clinical Trial Comparing Laparoscopic and Open Resection for Colon Cancer

Author

Stephan Wildi, H. Lippert, Hajime Maeta, Takashi Maeba, Shinichi Yachida, Luis Ortiz de Zárate, Thomas Kotsis, Levent Tezcan, Sadık Perek, Kimberley Giffard, K. Thon, Emre F. Yekebas, Javier Osorio, Ahmet Batkin, H. Stöltzing, Sasan Najibi, V. Zolota, Ola Røkke, V. Patrinou, Haldun Uluutku, Shawn M. Garber, Hisao Wakabayashi, Matthew G. Cohen, Esperanza Bachs, Mehmet Levhi Akin, Joseph Espat, Jean-Jacques Tuech, Núria Farreras, Moshe Schein, Asiye Perek, Metin Kapan, Sukru Yildirim, M.R.B. Keighley, Idunn Nesvik, Peter Lehocky, Agathi Paphiti, T. Manger, Nib Soehendra, Jean-Pierre Arnaud, Xavier Rogiers, G. Skroubis, Dionysios Voros, Christoph Busch, Bernhard Egger, Ronald S. Chamberlain, Charles Sklar, Jason P. Shaw, Leslie H. Blumgart, Cengiz Erenoglu, Julie Miller, Olof Winzer, C. Vagianos, Jonathan S. Zager, Michael G. Sarr, Elias Mallas, M. Pross, Stefan W. Schmid, Markus Naef, C. Haeckel, Eric R. Frykberg, Ian K. Komenaka, Ertuğrul Göksoy, Karl Søndenaa, Jules E. Garbus, Jakob R. Izbicki, A. Buttafuoco, Patrick Pessaux, Markus W. Büchler, and Matrona Frangou

Subjects
Male, Laparoscopic surgery, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, Malignancy, law.invention, Randomized controlled trial, Colon, Sigmoid, law, Open Resection, medicine, Humans, Laparoscopic resection, Prospective Studies, Laparoscopy, Colectomy, Aged, medicine.diagnostic_test, business.industry, fungi, Gastroenterology, food and beverages, Cancer, medicine.disease, Surgery, Europe, Sigmoid Neoplasms, Colonic Neoplasms, Female, business
Abstract

Background: Laparoscopic surgery has proven to be safe and effective. However, the value of laparoscopic resection for malignancy in terms of cancer outcome can only be assessed by large prospective randomized clinical trials with sufficient follow-up. Methods: COLOR (COlon carcinoma Laparoscopic or Open Resection) is a European multicenter randomized trial which has started in September 1997. In 24 hospitals in Sweden, The Netherlands, Germany, France, Italy and Spain, 1,200 patients will be included. The primary end point of the study is cancer-free survival after 3 years. Results: Within Conclusions: Although laparoscopic surgery appears of value in colorectal malignancy, results of randomized trials have to be awaited to determine the definitive place of laparoscopy in colorectal cancer. Considering the current accrual rate, the COLOR study will be completed in 2002.

Published
2000
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2. Early Enteral Feeding in Severe Acute Pancreatitis: Can It Prevent Secondary Pancreatic (Super) Infection?

Author

Peter Lehocky and Michael G. Sarr

Subjects
medicine.medical_specialty, Time Factors, Pancreatitis, Acute Necrotizing, business.industry, Gastroenterology, macromolecular substances, medicine.disease, Enteral administration, Pathogenesis, Sepsis, Enteral Nutrition, Pharmacotherapy, medicine.anatomical_structure, Intestinal mucosa, Gastric Mucosa, Bacterial Translocation, Superinfection, medicine, Humans, Acute pancreatitis, Pancreatitis, Surgery, Intensive care medicine, business, Pancreas
Abstract

Sepsis continues to account for a second peak in mortality in patients with severe acute pancreatitis. The prevention of these septic complications and subsequent development of multiple organ dysfunction syndrome remains a major focus for investigators, yet despite considerable clinical and experimental work addressing its etiology, septic complications remain high. Several studies have been designed to demonstrate the mechanism of origin of these septic complications with an attempt to define strategies for their prevention to improve patient outcomes. There is clear evidence that the origin of this secondary bacterial infection arises from enteric bacterial translocation secondary to disruption of the gut mucosal barrier during acute pancreatitis. Strategies designed to prevent secondary pancreatic infection include aggressive fluid resuscitation to maximize organ perfusion, early systemic antibiotic treatment or selective gut decontamination, and recently attempts to block mediators of the systemic inflammatory response. This discussion will summarize our present understanding of the etiopathogenesis of secondary bacterial ‘superinfection’ of necrotizing pancreatitis and how the initiation of enteral feeding early in the course of acute pancreatitis may prove to be an effective means of preventing and/or reversing the breakdown of the gut mucosal defense barrier.

Published
2000
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3. Subject Index Vol. 17, 2000

Author

Ertuğrul Göksoy, Jonathan S. Zager, Kimberley Giffard, Emre F. Yekebas, H. Stöltzing, Christoph Busch, Hajime Maeta, Takashi Maeba, Sukru Yildirim, Ronald S. Chamberlain, Dionysios Voros, Stephan Wildi, Haldun Uluutku, Agathi Paphiti, Xavier Rogiers, Núria Farreras, Stefan W. Schmid, G. Skroubis, Michael G. Sarr, V. Zolota, Luis Ortiz de Zárate, Jakob R. Izbicki, H. Lippert, Thomas Kotsis, Ola Røkke, Nib Soehendra, Markus W. Büchler, C. Vagianos, Metin Kapan, Karl Søndenaa, A. Buttafuoco, T. Manger, Mehmet Levhi Akin, Markus Naef, Jules E. Garbus, Matrona Frangou, Shawn M. Garber, Eric R. Frykberg, Charles Sklar, Jean-Pierre Arnaud, Hisao Wakabayashi, Patrick Pessaux, Sasan Najibi, Moshe Schein, Leslie H. Blumgart, Elias Mallas, Jean-Jacques Tuech, Peter Lehocky, M. Pross, Esperanza Bachs, Matthew G. Cohen, Jason P. Shaw, Cengiz Erenoglu, Julie Miller, Olof Winzer, Shinichi Yachida, Joseph Espat, Sadık Perek, Asiye Perek, Idunn Nesvik, K. Thon, Ahmet Batkin, Levent Tezcan, M.R.B. Keighley, Javier Osorio, Bernhard Egger, V. Patrinou, C. Haeckel, and Ian K. Komenaka

Subjects
medicine.medical_specialty, Index (economics), business.industry, Gastroenterology, Physical therapy, medicine, Physiology, Surgery, Subject (documents), business
Published
2000
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4. Contents Vol. 17, 2000

Author

Jakob R. Izbicki, Levent Tezcan, Joseph Espat, Stefan W. Schmid, Núria Farreras, Karl Søndenaa, M.R.B. Keighley, Javier Osorio, Jules E. Garbus, Shinichi Yachida, Asiye Perek, Idunn Nesvik, Nib Soehendra, Ronald S. Chamberlain, Bernhard Egger, T. Manger, K. Thon, Sasan Najibi, Sadık Perek, Ahmet Batkin, Mehmet Levhi Akin, Charles Sklar, Matthew G. Cohen, C. Vagianos, Markus W. Büchler, Cengiz Erenoglu, Leslie H. Blumgart, Julie Miller, Markus Naef, Stephan Wildi, Olof Winzer, Matrona Frangou, Eric R. Frykberg, Elias Mallas, M. Pross, V. Patrinou, Jason P. Shaw, C. Haeckel, V. Zolota, Luis Ortiz de Zárate, Thomas Kotsis, Ian K. Komenaka, Xavier Rogiers, G. Skroubis, Hajime Maeta, Takashi Maeba, Hisao Wakabayashi, Haldun Uluutku, Ola Røkke, Shawn M. Garber, Moshe Schein, Jean-Jacques Tuech, Peter Lehocky, Sukru Yildirim, Agathi Paphiti, H. Lippert, Esperanza Bachs, Patrick Pessaux, Jean-Pierre Arnaud, Michael G. Sarr, A. Buttafuoco, Ertuğrul Göksoy, Kimberley Giffard, Emre F. Yekebas, H. Stöltzing, Christoph Busch, Metin Kapan, Jonathan S. Zager, and Dionysios Voros

Subjects
Traditional medicine, business.industry, Gastroenterology, Medicine, Surgery, business
Published
2000
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