7 results on '"Peter Glerup"'
Search Results
2. Contributors
- Author
-
E. Terence Adams, Rick Adler, Carl L. Alden, Phillip M. Bartholomew, Joydeep Basu, Val R. Beasley, Brian R. Berridge, Timothy A. Bertram, Hyo-eun Bhang, Hugh E. Black, Brad Bolon, Gary A. Boorman, Denise I. Bounous, Rogely Waite Boyce, William M. Bracken, Amy E. Brix, Danielle Brown, Mark T. Butt, Glenn H. Cantor, Bruce D. Car, Vincent Castranova, Russell C. Cattley, Curtis Chan, Robert E. Chapin, Samuel M. Cohen, Steve Colegate, Daniel Cook, Paul S. Cooke, Torrie A. Crabbs, Dianne M. Creasy, James W. Crissman, John M. Cullen, Dimitry M. Danilenko, Barbara Davis, Myrtle A. Davis, T. Zane Davis, Ronald A. DeLellis, Nancy D. Denslow, Kelly L. Diegel, David C. Dorman, Richard R. Dubielzig, Stephen K. Durham, Sandy Eldridge, Susan A. Elmore, Jeffrey I. Everitt, Suzanne Fenton, Duncan C. Ferguson, Reuel Field, George L. Foley, William R. Foster, Jerry D. Frantz, Kathy Gabrielson, Shayne C. Gad, Elizabeth J. Galbreath, Dale R. Gardner, Robert H. Garman, Santokh Gill, Peter Glerup, Dale L. Goad, Mary Elizabeth Pecquet Goad, Nanna Grand, Benjamin T. Green, Kathryn E. Gropp, Hans Jørgen G. Gundersen, Diane Gunson, Ramesh C. Gupta, Sharon M. Gwaltney-Brant, Jeffery O. Hall, Wendy Halpern, Gordon C. Hard, Jerry F. Hardisty, Jack R. Harkema, Philip W. Harvey, Wanda M. Haschek, Kathleen Heinz-Taheny, Ronald A. Herbert, Eugene Herman, Mark Hoenerhoff, Ann Hubbs, David Hutto, Evan B. Janovitz, Kanwar Nasir M. Khan, Kevin P. Keenan, Roy L. Kerlin, John M. Kreeger, Kannan Krishnan, C. Frieke Kuper, Stephen T. Lee, Lois D. Lehman-McKeeman, Xiantang Li, Eric D. Lombardini, Calvert Louden, John W. Ludlow, David E. Malarkey, Peter C. Mann, Robert R. Maronpot, Kevin S. McDorman, Mark A. Melanson, Robert Mercer, Rosanna Mirabile, Ronald W. Moch, James P. Morrison, Daniel Morton, Laura Dill Morton, Sureshkumar Muthupalani, Kristen J. Nikula, Ricardo Ochoa, Michelle E. Pacheco-Thompson, Olga M. Pulido, Kip E. Panter, George A. Parker, Dale W. Porter, Douglas Reid Patterson, James A. Pfister, Carl A. Pinkert, Lila Ramaiah, Deepa B. Rao, Donald G. Robertson, Jennifer Rojko, Thomas J. Rosol, Colin G. Rousseaux, Daniel G. Rudmann, Christine Ruehl-Fehlert, Linda Sargent, Christina M. Satterwhite, Kenneth A. Schafer, Philip F. Solter, Robert C. Sills, Liz Simon, Mikala Skydsgaard, Graham S. Smith, Krishnan Sriram, Bryan L. Stegelmeier, John M. Sullivan, Catherine Sutcliffe, James A. Swenberg, Polina Sysa-Shah, Leandro Teixeira, Noriko Tsuchiya, John L. Vahle, John F. Van Vleet, Aurore Varela, Kenneth A. Voss, Robin M. Walker, Matthew A. Wallig, Gail L. Walter, Kevin D. Welch, Paul White, Christopher T. Winkelmann, Zbigniew W. Wojcinski, and Jeffrey C. Wolf more...
- Published
- 2013
- Full Text
- View/download PDF
Catalog
3. The Use of Minipigs in Non-Clinical Research
- Author
-
Mikala Skydsgaard, Nanna Grand, and Peter Glerup
- Subjects
Drug development ,Regulatory toxicology ,business.industry ,Non clinical ,Medicine ,Physiology ,Acute dermatitis ,Göttingen minipig ,Dosing ,Pharmacology ,business ,Animal species - Abstract
The choice of animal species in relation to non-clinical research should always be carefully considered and justified. Pigs and minipigs are considered good models for humans because they share some important characteristics with man. Swine exhibit particularly close resemblance to humans with respect to the anatomy of the skin, the cardiovascular system, the major part of the gastrointestinal tract, the nasal cavity, and the urogenital system. In addition, similarities are often found regarding metabolism of drugs and physiological parameters in these two species. In drug development, the intended clinical route of dosing should always be applied in non-clinical studies wherever possible. All general routes of product administration (i.e. dermal [topical and intradermal], intramuscular and intravenous, oral and subcutaneous) are practically feasible in pigs and minipigs. Furthermore, all generally required durations of dosing can be completed, with up to 12 months of daily dosing, depending on the route of dose administration. For regulatory toxicity studies, the minipig in particular should always be considered as a relevant test species. Indeed, the minipig is fully accepted by regulatory authorities worldwide. more...
- Published
- 2013
- Full Text
- View/download PDF
4. Wound Healing Models
- Author
-
Peter Glerup
- Subjects
medicine.medical_specialty ,business.industry ,medicine ,business ,Wound healing ,Surgery - Published
- 2011
- Full Text
- View/download PDF
5. Development of a porcine model for examining the effect of debriding agents
- Author
-
Peter Glerup, Jes Tovborg Jensen, Mikala Skydsgaard, and Signe Klastrup
- Subjects
business.industry ,Medicine ,Toxicology ,business ,Bioinformatics - Published
- 2010
- Full Text
- View/download PDF
6. The minipig as a model for intranasal dosing
- Author
-
Andy Makin, Peter Glerup, Lars Andersen, and Stig Mølgaard
- Subjects
business.industry ,Medicine ,Nasal administration ,Dosing ,Pharmacology ,Toxicology ,business - Published
- 2010
- Full Text
- View/download PDF
7. Development of a model for long-term bile collection in Göttingen minipigs
- Author
-
Anthony Webb, Peter Glerup, and Christina Skytte
- Subjects
medicine.medical_specialty ,Bile duct ,business.industry ,General Medicine ,Göttingen minipig ,Toxicology ,Diaphragm (structural system) ,Surgery ,Bile flow ,Catheter ,Biliary excretion ,medicine.anatomical_structure ,Port (medical) ,medicine ,Duodenum ,business - Abstract
Studying metabolism and elimination of exogenous substances includes investigation of potential biliary excretion of metabolites of the parent compound. Repeated sampling of bile for analysis in relation to dosing is therefore necessary, which requires surgical catheterisation of the bile duct. The Gottingen minipig is a commonly used species within nonclinical drug research due to the high level of similarity to humans. This also includes similarities in many drug metabolism pathways, as several porcine cytochromeP450’smetabolise the same test substrates as the human enzymes. For long termbile collection in consciousGottingenminipigswe have developed a catheterisation procedure allowing for repeated sampling, without disturbing the normal bile flow into the intestinal lumen, that otherwise could result in digestive and nutritional disturbances over time. A T-tube catheter with two side arms was inserted into the bile duct of four minipigs. The side arm towards the duodenum contained a conical diaphragm. Inflation of the diaphragm caused obstruction of normal bile flow, diverting the bile into the side arm towards the liver. Both side arms were tunnelled to the back and connected to vascular access ports, placed subcutaneously. This enclosed system allowed for bile collection when puncturing one port while inflating the diaphragm through the second port. The catheters were used for repeated bile collection in relation to two dosing occasions and remained patent for twoweeks. Study results and practical aspects of the procedure will be presented, including suggestions for method improvement. more...
- Published
- 2009
- Full Text
- View/download PDF
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.