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Background: In the last 30 years there has been an incidence increase of medullary carcinoma due to the development in diagnostic methods. MC represents 2% out of all thyroid carcinomas. Objective: Objective: Monitoring the therapeutic approach in medullary carcinoma Material and methods: Our retrospective analysis includes a cohort study of patients that underwent surgeries in 2nd Department of Surgery, UMFST Targu Mures, during 2018-2023. I have included individuals with the diagnosis of medullary carcinoma, meanwhile the exclusion criteria were: other type of thyroid dysfunction that underwent surgery, or associated with other types of anomalies (parathyroid). The results were statistically analyzed. Results: Within the examined period there were 422 cases of thyroid intervention, including 4% of which were represented by medullary carcinoma. 75% of those cases were women and 25% men, with the average age of 55. In 7% of the cases, the tumor was located in both lobes, 27% in the left lobe, and 67% in the right lobe. In 5 of the cases, total thyroidectomy (TT) was performed with CCND (central compartment neck dissection) and selective bilateral neck dissection; in 4 cases TT with CCND and selective unilateral neck dissection; one case of TT with CCND; 4 cases of TT; one case of right isthmolobectomy; one case of reoccurrence in central compartment Conclusions: Medullary carcinoma is a rare oncological condition which requires an extensive approach based on the clinical stage of the disease. [ABSTRACT FROM AUTHOR]