1. Ciclosporin-responsive pyoderma in dogs: A comparison to human pyoderma gangrenosum.
- Author
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De Lucia, Michela, Orlandini, Paola, Denti, Daria, Berto, Laura, Mezzalira, Giorgia, Peserico, Andrea, and Fortina, Anna Belloni
- Subjects
PYODERMA gangrenosum ,C-reactive protein ,BACTERIAL diseases ,CYCLOSPORINE ,DOGS - Abstract
We describe 20 cases of canine pyoderma responsive to immunosuppressive treatments and resembling human pyoderma gangrenosum. All dogs presented with a rapidly evolving, focal to multifocal, painful ulcerative dermatitis, non-responsive to multiple antibiotic and anti-inflammatory therapies. Elevations of C-reactive protein (100%), neutrophilia (75%) and fever (25%) were also present. Histopathology showed a severe, ulcerative, superficial to deep, predominantly neutrophilic dermatitis. Bacterial infection was the most challenging differential diagnosis. Resolution of the lesions was obtained within 4-8 weeks in 83% of dogs treated with ciclosporin. Maintenance treatment was required in the majority of the dogs. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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