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1. Additional copies of 1q negatively impact the outcome of multiple myeloma patients and induce transcriptomic deregulation in malignant plasma cells

Author

D’Agostino, Mattia, Rota-Scalabrini, Delia, Belotti, Angelo, Bertamini, Luca, Arigoni, Maddalena, De Sabbata, Giovanni, Pietrantuono, Giuseppe, Pascarella, Anna, Tosi, Patrizia, Pisani, Francesco, Pescosta, Norbert, Ruggeri, Marina, Rogers, Jennifer, Olivero, Martina, Garzia, Mariagrazia, Galieni, Piero, Annibali, Ombretta, Monaco, Federico, Liberati, Anna Marina, Palmieri, Salvatore, Stefanoni, Paola, Zamagni, Elena, Bruno, Benedetto, Calogero, Raffaele Adolfo, Boccadoro, Mario, Musto, Pellegrino, and Gay, Francesca

Published
2024
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2. A real-life study of daratumumab-bortezomib-dexamethasone (D-VD) in lenalidomide exposed/refractory multiple myeloma patients: a report from the Triveneto Myeloma Working Group

Author

Barilà, Gregorio, Quaglia, Francesca Maria, Furlan, Anna, Pescosta, Norbert, Bonalumi, Angela, Marcon, Chiara, Pascarella, Anna, Tinelli, Martina, De March, Elena, Lico, Albana, Sartori, Roberto, Clissa, Cristina, De Sabbata, Giovanni, Nappi, Davide, Porrazzo, Marika, De Marchi, Roberta, Pavan, Laura, Tosetto, Alberto, Gherlinzoni, Filippo, Krampera, Mauro, Bassan, Renato, Patriarca, Francesca, Semenzato, Gianpietro, and Zambello, Renato

Published
2024
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3. Bortezomib, thalidomide, and dexamethasone followed by double autologous haematopoietic stem-cell transplantation for newly diagnosed multiple myeloma (GIMEMA-MMY-3006): long-term follow-up analysis of a randomised phase 3, open-label study

Author

Cavo, Michele, Fanin, Renato, Foa', Roberto, Rambaldi, Alessandro, Di Raimondo, Francesco, Rossi, Giuseppe, Boccadoro, Mario, Leoni, Pietro, Corradini, Paolo, Torelli, Giuseppe, Fioritoni, Giuseppe, Cortelazzo, Sergio, Lambertenghi Deliliers, Giorgio, La Nasa, Giorgio, Zaccaria, Alfonso, De Fabritiis, Paolo, Cascavilla, Nicola, Bosi, Alberto, Semenzato, Gianpietro, Gugliotta, Luigi, Gherlinzoni, Filippo, Angelucci, Emanuele, Martelli, Massimo Fabrizio, Petti, Maria Concetta, Leone, Giuseppe, Carella, Angelo Michele, Ciceri, Fabio, Santoro, Armando, Ferrara, Felicetto, Nobile, Francesco, D'Arco, Alfonso Maria, Levis, Alessandro, Guardigni, Luciano, Gallamini, Andrea, Musto, Pellegrino, Fattori, Pier Paolo, Galieni, Piero, Morandi, Sergio, Amadori, Dino, Gobbi, Marco, Rotoli, Bruno, Mirto, Salvatore, Lazzaro, Antonio, Paladini, Giorgio, Mozzana, Ruggero, Pinotti, Graziella, Rodeghiero, Francesco, Cantore, Nicola, Pavone, Vincenzo, Pogliani, Enrico Maria, Liberati, Anna Marina, Majolino, Ignazio, Amadori, Sergio, Lauria, Francesco, Aglietta, Massimo, Quarta, Giovanni, Storti, Sergio, Morabito, Fortunato, Capalbo, Silvana Franca, Gianni, Alessandro Massimo, Mettivier, Vincenzo, Rizzoli, Vittorio, Bernasconi, Carlo, Visani, Giuseppe, Pizzuti, Michele, La Verde, Giacinto, Avvisati, Giuseppe, Longinotti, Maurizio, Gallo, Eugenio, Dammacco, Franco, Russo, Domenico, Bacigalupo, Andrea, Musolino, Caterina, Tacchetti, Paola, Pantani, Lucia, Patriarca, Francesca, Petrucci, Maria Teresa, Zamagni, Elena, Dozza, Luca, Galli, Monica, Crippa, Claudia, Barbato, Simona, Tosi, Patrizia, Narni, Franco, Montefusco, Vittorio, Testoni, Nicoletta, Spadano, Antonio, Terragna, Carolina, Pescosta, Norbert, Marzocchi, Giulia, Cellini, Claudia, Ronconi, Sonia, Catalano, Lucio, De Sabbata, Giovanni, Cangialosi, Clotilde, Ciambelli, Fabrizio, and Elice, Francesca

Published
2020
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4. A real‐world retrospective–prospective analysis of efficacy and safety of combined ixazomib, lenalidomide, and dexamethasone in relapsed/refractory multiple myeloma: The northern Italy experience

Author

Furlan, Anna, primary, Cea, Michele, additional, Pavan, Laura, additional, Galli, Monica, additional, Clissa, Cristina, additional, Mangiacavalli, Silvia, additional, Cafro, Anna Maria, additional, Girlanda, Stefania, additional, Patriarca, Francesca, additional, Minotto, Claudia, additional, Bertoldero, Giovanni, additional, Barilà, Gregorio, additional, Pascarella, Anna, additional, Lico, Albana, additional, Paolini, Rossella, additional, Rabassi, Nicholas, additional, Pescosta, Norbert, additional, Porrazzo, Marika, additional, De Sabbata, Giovanni, additional, Pompa, Alessandra, additional, Bega, Giulia, additional, Cavallin, Stefania, additional, Guidotti, Francesca, additional, Marcatti, Magda, additional, Rupolo, Maurizio, additional, Belotti, Angelo, additional, Gherlinzoni, Filippo, additional, and Zambello, Renato, additional

Published
2024
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5. Ixazomib-based induction regimens plus ixazomib maintenance in transplant-ineligible, newly diagnosed multiple myeloma: the phase II, multi-arm, randomized UNITO-EMN10 trial

Author

Mina, Roberto, Falcone, Antonietta Pia, Bringhen, Sara, Liberati, Anna Marina, Pescosta, Norbert, Petrucci, Maria Teresa, Ciccone, Giovannino, Capra, Andrea, Patriarca, Francesca, Rota-Scalabrini, Delia, Bonello, Francesca, Musolino, Caterina, Cea, Michele, Zambello, Renato, Tacchetti, Paola, Belotti, Angelo, Cellini, Claudia, Paris, Laura, Grasso, Mariella, Aquino, Sara, De Paoli, Lorenzo, De Sabbata, Giovanni, Ballanti, Stelvio, Offidani, Massimo, Boccadoro, Mario, Monaco, Federico, Corradini, Paolo, and Larocca, Alessandra

Published
2021
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6. Additional copies of 1q negatively impact the outcome of multiple myeloma patients and induce transcriptomic deregulation in malignant plasma cells.

Author

D'Agostino, Mattia, Rota-Scalabrini, Delia, Belotti, Angelo, Bertamini, Luca, Arigoni, Maddalena, De Sabbata, Giovanni, Pietrantuono, Giuseppe, Pascarella, Anna, Tosi, Patrizia, Pisani, Francesco, Pescosta, Norbert, Ruggeri, Marina, Rogers, Jennifer, Olivero, Martina, Garzia, Mariagrazia, Galieni, Piero, Annibali, Ombretta, Monaco, Federico, Liberati, Anna Marina, and Palmieri, Salvatore

Subjects
MULTIPLE myeloma, CANCER cells, PLASMA cells, STEM cell transplantation, TRANSCRIPTOMES
Abstract

Additional copies of chromosome 1 long arm (1q) are frequently found in multiple myeloma (MM) and predict high-risk disease. Available data suggest a different outcome and biology of patients with amplification (Amp1q, ≥4 copies of 1q) vs. gain (Gain1q, 3 copies of 1q) of 1q. We evaluated the impact of Amp1q/Gain1q on the outcome of newly diagnosed MM patients enrolled in the FORTE trial (NCT02203643). Among 400 patients with available 1q data, 52 (13%) had Amp1q and 129 (32%) Gain1q. After a median follow-up of 62 months, median progression-free survival (PFS) was 21.2 months in the Amp1q group, 54.9 months in Gain1q, and not reached (NR) in Normal 1q. PFS was significantly hampered by the presence of Amp1q (HR 3.34 vs. Normal 1q, P < 0.0001; HR 1.99 vs. Gain1q, P = 0.0008). Patients with Gain1q had also a significantly shorter PFS compared with Normal 1q (HR 1.68, P = 0.0031). Concomitant poor prognostic factors or the failure to achieve MRD negativity predicted a median PFS < 12 months in Amp1q patients. Carfilzomib–lenalidomide–dexamethasone plus autologous stem cell transplantation treatment improved the adverse effect of Gain1q but not Amp1q. Transcriptomic data showed that additional 1q copies were associated with deregulation in apoptosis signaling, p38 MAPK signaling, and Myc-related genes. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Treatment Intensification With Autologous Stem Cell Transplantation and Lenalidomide Maintenance Improves Survival Outcomes of Patients With Newly Diagnosed Multiple Myeloma in Complete Response

Author

Mina, Roberto, Petrucci, Maria Teresa, Corradini, Paolo, Spada, Stefano, Patriarca, Francesca, Cerrato, Chiara, De Paoli, Lorenzo, Pescosta, Norbert, Ria, Roberto, Malfitano, Alessandra, Musto, Pellegrino, Baldini, Luca, Guglielmelli, Tommasina, Gamberi, Barbara, Mannina, Donato, Benevolo, Giulia, Zambello, Renato, Falcone, Antonietta Pia, Palumbo, Antonio, Nagler, Arnon, Calafiore, Valeria, Hájek, Roman, Spencer, Andrew, Boccadoro, Mario, and Bringhen, Sara

Published
2018
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8. A real-life study of daratumumab-bortezomib-dexamethasone (D-VD) in lenalidomide exposed/refractory multiple myeloma patients: a report from the Triveneto Myeloma Working Group

Author

Barilà, Gregorio, primary, Quaglia, Francesca Maria, additional, Furlan, Anna, additional, Pescosta, Norbert, additional, Bonalumi, Angela, additional, Marcon, Chiara, additional, Pascarella, Anna, additional, Tinelli, Martina, additional, De March, Elena, additional, Lico, Albana, additional, Sartori, Roberto, additional, Clissa, Cristina, additional, De Sabbata, Giovanni, additional, Nappi, Davide, additional, Porrazzo, Marika, additional, De Marchi, Roberta, additional, Pavan, Laura, additional, Tosetto, Alberto, additional, Gherlinzoni, Filippo, additional, Krampera, Mauro, additional, Bassan, Renato, additional, Patriarca, Francesca, additional, Semenzato, Gianpietro, additional, and Zambello, Renato, additional

Published
2023
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9. P970: A REAL-WORLD RETROSPECTIVE-PROSPECTIVE ANALYSIS OF EFFICACY AND SAFETY OF COMBINED IXAZOMIB, LENALIDOMIDE AND DEXAMETHASONE IN RELAPSED/REFRACTORY MULTIPLE MYELOMA: THE NORTHERN ITALY EXPERIENCE

Author

Furlan, Anna, primary, Cea, Michele, additional, Zambello, Renato, additional, Pavan, Laura, additional, Galli, Monica, additional, Clissa, Cristina, additional, Mangiacavalli, Silvia, additional, Maria Cafro, Anna, additional, Girlanda, Stefania, additional, Patriarca, Francesca, additional, Minotto, Claudia, additional, Bertoldero, Giovanni, additional, Barilà, Gregorio, additional, Pascarella, Anna, additional, Lico, Albana, additional, Paolini, Rossella, additional, Rabassi, Nicholas, additional, Pescosta, Norbert, additional, Porrazzo, Marika, additional, and Gherlinzoni, Filippo, additional

Published
2023
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10. Bortezomib-dexamethasone as maintenance therapy or early retreatment at biochemical relapse versus observation in relapsed/refractory multiple myeloma patients: a randomized phase II study

Author

Mina, Roberto, Belotti, Angelo, Petrucci, Maria Teresa, Zambello, Renato, Capra, Andrea, Di Lullo, Giacomo, Ronconi, Sonia, Pescosta, Norbert, Grasso, Mariella, Monaco, Federico, Cellini, Claudia, Gobbi, Marco, Ballanti, Stelvio, de Fabritiis, Paolo, Mosca-Siez, Maria Letizia, Marchetti, Monia, Liberati, Anna Marina, Offidani, Massimo, Giuliani, Nicola, Ria, Roberto, Musto, Pellegrino, Romano, Alessandra, Sonneveld, Pieter, Boccadoro, Mario, and Larocca, Alessandra

Published
2020
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11. Chemotherapy plus lenalidomide versus autologous transplantation, followed by lenalidomide plus prednisone versus lenalidomide maintenance, in patients with multiple myeloma: a randomised, multicentre, phase 3 trial

Author

Gay, Francesca, Oliva, Stefania, Petrucci, Maria Teresa, Conticello, Concetta, Catalano, Lucio, Corradini, Paolo, Siniscalchi, Agostina, Magarotto, Valeria, Pour, Luděk, Carella, Angelo, Malfitano, Alessandra, Petrò, Daniela, Evangelista, Andrea, Spada, Stefano, Pescosta, Norbert, Omedè, Paola, Campbell, Philip, Liberati, Anna Marina, Offidani, Massimo, Ria, Roberto, Pulini, Stefano, Patriarca, Francesca, Hajek, Roman, Spencer, Andrew, Boccadoro, Mario, and Palumbo, Antonio

Published
2015
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12. Carfilzomib induction, consolidation, and maintenance with or without autologous stem-cell transplantation in patients with newly diagnosed multiple myeloma: pre-planned cytogenetic subgroup analysis of the randomised, phase 2 FORTE trial

Author

Mina, Roberto, primary, Musto, Pellegrino, additional, Rota-Scalabrini, Delia, additional, Paris, Laura, additional, Gamberi, Barbara, additional, Palmas, Angelo, additional, Aquino, Sara, additional, de Fabritiis, Paolo, additional, Giuliani, Nicola, additional, De Rosa, Luca, additional, Gozzetti, Alessandro, additional, Cellini, Claudia, additional, Bertamini, Luca, additional, Capra, Andrea, additional, Oddolo, Daniela, additional, Vincelli, Iolanda Donatella, additional, Ronconi, Sonia, additional, Pavone, Vincenzo, additional, Pescosta, Norbert, additional, Cea, Michele, additional, Fioritoni, Francesca, additional, Ballanti, Stelvio, additional, Grasso, Mariella, additional, Zamagni, Elena, additional, Belotti, Angelo, additional, Boccadoro, Mario, additional, and Gay, Francesca, additional

Published
2023
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13. Bortezomib induction, reduced-intensity transplantation, and lenalidomide consolidation-maintenance for myeloma: updated results

Author

Gay, Francesca, Magarotto, Valeria, Crippa, Claudia, Pescosta, Norbert, Guglielmelli, Tommasina, Cavallo, Federica, Pezzatti, Sara, Ferrari, Samantha, Liberati, Anna Marina, Oliva, Stefania, Patriarca, Francesca, Offidani, Massimo, Omedé, Paola, Montefusco, Vittorio, Petrucci, Maria Teresa, Giuliani, Nicola, Passera, Roberto, Pietrantuono, Giuseppe, Boccadoro, Mario, Corradini, Paolo, and Palumbo, Antonio

Published
2013
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14. Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study

Author

Cavo, Michele, Tacchetti, Paola, Patriarca, Francesca, Petrucci, Maria Teresa, Pantani, Lucia, Galli, Monica, Di Raimondo, Francesco, Crippa, Claudia, Zamagni, Elena, Palumbo, Antonio, Offidani, Massimo, Corradini, Paolo, Narni, Franco, Spadano, Antonio, Pescosta, Norbert, Deliliers, Giorgio Lambertenghi, Ledda, Antonio, Cellini, Claudia, Caravita, Tommaso, Tosi, Patrizia, and Baccarani, Michele

Published
2010
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15. OAB-055: Gain and amplification of 1q induce transcriptome deregulation and worsen the outcome of newly diagnosed Multiple Myeloma patients

Author

D’Agostino, Mattia, primary, Belotti, Angelo, additional, Zamagni, Elena, additional, Auclair, Daniel, additional, Zambello, Renato, additional, Arigoni, Maddalena, additional, Spadano, Antonio, additional, Cea, Michele, additional, Pescosta, Norbert, additional, Ronconi, Sonia, additional, Olivero, Martina, additional, Musolino, Caterina, additional, Genuardi, Elisa, additional, Molica, Stefano, additional, Pavone, Vincenzo, additional, Patriarca, Francesca, additional, Fabritiis, Paolo de, additional, Gamberi, Barbara, additional, Calogero, Raffaele Adolfo, additional, Offidani, Massimo, additional, Galli, Monica, additional, Musto, Pellegrino, additional, Boccadoro, Mario, additional, and Gay, Francesca, additional

Published
2021
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16. Lenalidomide Maintenance after VTD Induction and Autologous Stem Cell Transplantation: An Italian Real-Life Study of 558 Patients

Author

Barila, Gregorio, Grassi, Angela, Conticello, Concetta, Mina, Roberto, Marcon, Chiara, Fazio, Francesca, Cartia, Claudio Salvatore, Tinelli, Martina, Del Giudice, Maria Livia, Pilerci, Sofia, Belotti, Angelo, Pascarella, Anna, Tafuri, Mariantonietta, Rocchi, Serena, Sgherza, Nicola, Mele, Giuseppe, Scomazzon, Edoardo, Gentile, Massimo, Porrazzo, Marika, Pescosta, Norbert, Furlan, Anna, Febbo, Massimiliano Arangio, Clissa, Cristina, Casson, Andrea, Ribolla, Rossella, Maroccia, Antonio, Lisi, Chiara, Martino, Enrica Antonia, Annibali, Ombretta, Buda, Gabriele, Antonioli, Elisabetta, Mangiacavalli, Silvia, Tosetto, Alberto, Musto, Pellegrino, Gay, Francesca, Zamagni, Elena, Petrucci, Maria Teresa, Di Raimondo, Francesco, Patriarca, Francesca, and Zambello, Renato

Published
2023
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17. Iberdomide Maintenance after Autologous Stem-Cell Transplantation in Newly Diagnosed MM: First Results of the Phase 2 EMN26 Study

Author

van de Donk, Niels W.C.J., Touzeau, Cyrille, Terpos, Evangelos, Perrot, Aurore, Mina, Roberto, de Ruijter, Maaike, Antonioli, Elisabetta, Katodritou, Eirini, Pescosta, Norbert, Geerts, Paulus A.F., Sonntag, Cécile, Wester, Ruth, Belotti, Angelo, Mangiacavalli, Silvia, Offidani, Massimo, D'Agostino, Mattia, van Duin, Mark, Cavo, Michele, Aquino, Sara, Lombardo, Alessandra, Levin, Mark-David, Hulin, Cyrille, Boccadoro, Mario, Sonneveld, Pieter, and Gay, Francesca

Published
2023
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21. Bortezomib, thalidomide, and dexamethasone followed by double autologous haematopoietic stem-cell transplantation for newly diagnosed multiple myeloma (GIMEMA-MMY-3006): long-term follow-up analysis of a randomised phase 3, open-label study

Author

Tacchetti, Paola, primary, Pantani, Lucia, additional, Patriarca, Francesca, additional, Petrucci, Maria Teresa, additional, Zamagni, Elena, additional, Dozza, Luca, additional, Galli, Monica, additional, Di Raimondo, Francesco, additional, Crippa, Claudia, additional, Boccadoro, Mario, additional, Barbato, Simona, additional, Tosi, Patrizia, additional, Narni, Franco, additional, Montefusco, Vittorio, additional, Testoni, Nicoletta, additional, Spadano, Antonio, additional, Terragna, Carolina, additional, Pescosta, Norbert, additional, Marzocchi, Giulia, additional, Cellini, Claudia, additional, Galieni, Piero, additional, Ronconi, Sonia, additional, Gobbi, Marco, additional, Catalano, Lucio, additional, Lazzaro, Antonio, additional, De Sabbata, Giovanni, additional, Cangialosi, Clotilde, additional, Ciambelli, Fabrizio, additional, Musto, Pellegrino, additional, Elice, Francesca, additional, Cavo, Michele, additional, Fanin, Renato, additional, Foa', Roberto, additional, Rambaldi, Alessandro, additional, Rossi, Giuseppe, additional, Leoni, Pietro, additional, Corradini, Paolo, additional, Torelli, Giuseppe, additional, Fioritoni, Giuseppe, additional, Cortelazzo, Sergio, additional, Lambertenghi Deliliers, Giorgio, additional, La Nasa, Giorgio, additional, Zaccaria, Alfonso, additional, De Fabritiis, Paolo, additional, Cascavilla, Nicola, additional, Bosi, Alberto, additional, Semenzato, Gianpietro, additional, Gugliotta, Luigi, additional, Gherlinzoni, Filippo, additional, Angelucci, Emanuele, additional, Martelli, Massimo Fabrizio, additional, Petti, Maria Concetta, additional, Leone, Giuseppe, additional, Carella, Angelo Michele, additional, Ciceri, Fabio, additional, Santoro, Armando, additional, Ferrara, Felicetto, additional, Nobile, Francesco, additional, D'Arco, Alfonso Maria, additional, Levis, Alessandro, additional, Guardigni, Luciano, additional, Gallamini, Andrea, additional, Fattori, Pier Paolo, additional, Morandi, Sergio, additional, Amadori, Dino, additional, Rotoli, Bruno, additional, Mirto, Salvatore, additional, Paladini, Giorgio, additional, Mozzana, Ruggero, additional, Pinotti, Graziella, additional, Rodeghiero, Francesco, additional, Cantore, Nicola, additional, Pavone, Vincenzo, additional, Pogliani, Enrico Maria, additional, Liberati, Anna Marina, additional, Majolino, Ignazio, additional, Amadori, Sergio, additional, Lauria, Francesco, additional, Aglietta, Massimo, additional, Quarta, Giovanni, additional, Storti, Sergio, additional, Morabito, Fortunato, additional, Capalbo, Silvana Franca, additional, Gianni, Alessandro Massimo, additional, Mettivier, Vincenzo, additional, Rizzoli, Vittorio, additional, Bernasconi, Carlo, additional, Visani, Giuseppe, additional, Pizzuti, Michele, additional, La Verde, Giacinto, additional, Avvisati, Giuseppe, additional, Longinotti, Maurizio, additional, Gallo, Eugenio, additional, Dammacco, Franco, additional, Russo, Domenico, additional, Bacigalupo, Andrea, additional, and Musolino, Caterina, additional

Published
2020
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22. Ixazomib-Based Induction Followed By Single-Agent Ixazomib Maintenance in Transplant Ineligible, Newly Diagnosed Multiple Myeloma Patients: Updated Results of the EMN10-Unito Trial

Author

Mina, Roberto, primary, Larocca, Alessandra, additional, Corradini, Paolo, additional, Cascavilla, Nicola, additional, Liberati, Anna Marina, additional, Pescosta, Norbert, additional, Fazio, Francesca, additional, Ciccone, Giovannino, additional, Capra, Andrea, additional, Patriarca, Francesca, additional, Bernardini, Annalisa, additional, Rota Scalabrini, Delia, additional, Cea, Michele, additional, Zambello, Renato, additional, Baraldi, Anna, additional, Belotti, Angelo, additional, Boccadoro, Mario, additional, and Bringhen, Sara, additional

Published
2020
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23. Impact of Minimal Residual Disease (MRD) By Multiparameter Flow Cytometry (MFC) and Next-Generation Sequencing (NGS) on Outcome: Results of Newly Diagnosed Transplant-Eligible Multiple Myeloma (MM) Patients Enrolled in the Forte Trial

Author

Oliva, Stefania, primary, Genuardi, Elisa, additional, Petrucci, Maria Teresa, additional, D'Agostino, Mattia, additional, Auclair, Daniel, additional, Spadano, Antonio, additional, Jacob, Allison P., additional, Cea, Michele, additional, De Rosa, Luca, additional, Gozzetti, Alessandro, additional, Ruggeri, Marina, additional, Capra, Andrea, additional, Gilestro, Milena, additional, Pescosta, Norbert, additional, Palmas, Angelo D., additional, Siniscalchi, Agostina, additional, Kirsch, Ilan R., additional, Corradini, Paolo, additional, Musto, Pellegrino, additional, Boccadoro, Mario, additional, Zamagni, Elena, additional, and Gay, Francesca, additional

Published
2020
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25. Efficacy and Safety of Ixazomib-Dexamethasone, Ixazomib-Cyclophosphamide-Dexamethasone, Ixazomib-Thalidomide-Dexamethasone and Ixazomib-Bendamustine-Dexamethasone for Elderly Newly Diagnosed Multiple Myeloma (NDMM) Patients: Analysis of the Phase II Randomized Unito-EMN10 Study

Author

Larocca, Alessandra, primary, Corradini, Paolo, additional, Mina, Roberto, additional, Cascavilla, Nicola, additional, Liberati, Anna Marina, additional, Pescosta, Norbert, additional, Petrucci, Maria Teresa, additional, Ciccone, Giovannino, additional, Capra, Andrea, additional, Patriarca, Francesca, additional, Rota Scalabrini, Delia, additional, Innao, Vanessa, additional, Poggiu, Marco, additional, Cea, Michele, additional, Zambello, Renato, additional, Baraldi, Anna, additional, Belotti, Angelo, additional, Cellini, Claudia, additional, Galli, Monica, additional, Grasso, Mariella, additional, Aquino, Sara, additional, Margiotta Casaluci, Gloria, additional, De Sabbata, Giovanni, additional, Ballanti, Stelvio, additional, Offidani, Massimo, additional, Mancuso, Katia, additional, Boccadoro, Mario, additional, and Bringhen, Sara, additional

Published
2019
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26. Integrative Analysis of Baseline Prognostic Features and Achievement of Minimal Residual Disease Negativity As Predictors of Early Relapse in Transplant-Eligible Multiple Myeloma Patients

Author

Gay, Francesca, primary, Zaccaria, Gian Maria, primary, Offidani, Massimo, primary, Vozella, Federico, primary, Becco, Paolo, primary, Belotti, Angelo, primary, Capra, Andrea, primary, Galli, Monica, primary, Morabito, Fortunato, primary, Bertamini, Luca, primary, Pisani, Francesco, primary, Galieni, Piero, primary, Rizzi, Rita, primary, Gozzetti, Alessandro, primary, Pescosta, Norbert, primary, De Rosa, Luca, primary, Narni, Franco, primary, Gilestro, Milena, primary, Palmieri, Salvatore, primary, Cea, Michele, primary, Tosi, Patrizia, primary, Giuliani, Nicola, primary, Musto, Pellegrino, primary, Cavo, Michele, primary, and Boccadoro, Mario, primary

Published
2019
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27. Lenalidomide-based induction and maintenance in elderly newly diagnosed multiple myeloma patients: updated results of the EMN01 randomized trial

Author

Bringhen, Sara, primary, D’Agostino, Mattia, additional, Paris, Laura, additional, Ballanti, Stelvio, additional, Pescosta, Norbert, additional, Spada, Stefano, additional, Pezzatti, Sara, additional, Grasso, Mariella, additional, Rota-Scalabrini, Delia, additional, De Rosa, Luca, additional, Pavone, Vincenzo, additional, Gazzera, Giulia, additional, Aquino, Sara, additional, Poggiu, Marco, additional, Santoro, Armando, additional, Gentile, Massimo, additional, Baldini, Luca, additional, Petrucci, Maria Teresa, additional, Tosi, Patrizia, additional, Marasca, Roberto, additional, Cellini, Claudia, additional, Palumbo, Antonio, additional, Falco, Patrizia, additional, Hájek, Roman, additional, Boccadoro, Mario, additional, and Larocca, Alessandra, additional

Published
2019
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28. Maintenance Therapy vs Re-treatment at Biochemical Relapse vs Observation in Relapsed/Refractory Multiple Myeloma Patients: Results of a Phase II, Randomized Study

Author

Mina, Roberto, primary, Larocca, Alessandra, additional, Belotti, Angelo, additional, Conticello, Concetta, additional, Monaco, Federico, additional, Offidani, Massimo, additional, Ronconi, Sonia, additional, Marchetti, Monia, additional, Ria, Roberto, additional, Mosca-Siez, Maria Letizia, additional, Pescosta, Norbert, additional, Grasso, Mariella, additional, Capra, Andrea, additional, Zambello, Renato, additional, Poggiu, Marco, additional, Giuliani, Nicola, additional, Ballanti, Stelvio, additional, Cellini, Claudia, additional, Liberati, Anna Marina, additional, Siniscalchi, Agostina, additional, Petrucci, Maria Teresa, additional, Palumbo, Antonio, additional, Musto, Pellegrino, additional, Sonneveld, Pieter, additional, and Boccadoro, Mario, additional

Published
2019
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30. Bortezomib-Thalidomide-Dexamethasone Versus Thalidomide-Dexamethasone before and after Double Autologous Stem Cell Transplantation for Newly Diagnosed Multiple Myeloma: Final Analysis of Phase 3 Gimema-MMY-3006 Study and Prognostic Score for Survival Outcomes

Author

Tacchetti, Paola, primary, Dozza, Luca, additional, Di Raimondo, Francesco, additional, Crippa, Claudia, additional, Zamagni, Elena, additional, Bringhen, Sara, additional, Pantani, Lucia, additional, Offidani, Massimo, additional, Montefusco, Vittorio, additional, Narni, Franco, additional, Mancuso, Katia, additional, Cellini, Claudia, additional, Spadano, Antonio, additional, Pescosta, Norbert, additional, Baldini, Luca, additional, Terragna, Carolina, additional, Nozzoli, Chiara, additional, Zambello, Renato, additional, Derudas, Daniele, additional, Ballanti, Stelvio, additional, and Cavo, Michele, additional

Published
2018
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31. Carfilzomib-Lenalidomide-Dexamethasone (KRd) Induction-Autologous Transplant (ASCT)-Krd Consolidation Vs KRd 12 Cycles Vs Carfilzomib-Cyclophosphamide-Dexamethasone (KCd) Induction-ASCT-KCd Consolidation: Analysis of the Randomized Forte Trial in Newly Diagnosed Multiple Myeloma (NDMM)

Author

Gay, Francesca, primary, Cerrato, Chiara, additional, Rota Scalabrini, Delia, additional, Galli, Monica, additional, Belotti, Angelo, additional, Zamagni, Elena, additional, Ledda, Antonio, additional, Grasso, Mariella, additional, Angelucci, Emanuele, additional, Liberati, Anna Marina, additional, Tosi, Patrizia, additional, Pisani, Francesco, additional, Spada, Stefano, additional, Annibali, Ombretta, additional, Baraldi, Anna, additional, Omedé, Paola, additional, Galieni, Piero, additional, Rizzi, Rita, additional, Pescosta, Norbert, additional, Ronconi, Sonia, additional, Vincelli, Donatella, additional, Cafro, Anna Maria, additional, Offidani, Massimo, additional, Palumbo, Antonio, additional, Musto, Pellegrino, additional, Cavo, Michele, additional, and Boccadoro, Mario, additional

Published
2018
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32. Efficacy and Feasibility of Dose/Schedule-Adjusted Rd-R Vs. Continuous Rd in Elderly and Intermediate-Fit Newly Diagnosed Multiple Myeloma (NDMM) Patients: RV-MM-PI-0752 Phase III Randomized Study

Author

Larocca, Alessandra, primary, Salvini, Marco, additional, De Paoli, Lorenzo, additional, Cascavilla, Nicola, additional, Benevolo, Giulia, additional, Galli, Monica, additional, Montefusco, Vittorio, additional, Caravita di Toritto, Tommaso, additional, Baraldi, Anna, additional, Spada, Stefano, additional, Giuliani, Nicola, additional, Pautasso, Chiara, additional, Pulini, Stefano, additional, Ronconi, Sonia, additional, Pescosta, Norbert, additional, Liberati, Anna Marina, additional, Patriarca, Francesca, additional, Cellini, Claudia, additional, Tosi, Patrizia, additional, Offidani, Massimo, additional, Cavo, Michele, additional, Palumbo, Antonio, additional, Boccadoro, Mario, additional, and Bringhen, Sara, additional

Published
2018
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33. Phase II trial to investigate efficacy and safety of bendamustine, dexamethasone and thalidomide in relapsed or refractory multiple myeloma patients after treatment with lenalidomide and bortezomib

Author

Mian, Michael, primary, Pescosta, Norbert, additional, Badiali, Stefania, additional, Cappelletto, Paola Cristina, additional, Marcheselli, Luigi, additional, Luminari, Stefano, additional, Patriarca, Francesca, additional, Zambello, Renato, additional, Pascarella, Anna, additional, Tagariello, Giuseppe, additional, Marabese, Alessandra, additional, Mondello, Patrizia, additional, Billio, Atto, additional, and Cortelazzo, Sergio, additional

Published
2018
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34. Phase II trial to investigate efficacy and safety of bendamustine, dexamethasone and thalidomide in relapsed or refractory multiple myeloma patients after treatment with lenalidomide and bortezomib.

Author

Mian, Michael, Pescosta, Norbert, Badiali, Stefania, Cappelletto, Paola Cristina, Marcheselli, Luigi, Luminari, Stefano, Patriarca, Francesca, Zambello, Renato, Pascarella, Anna, Tagariello, Giuseppe, Marabese, Alessandra, Mondello, Patrizia, Billio, Atto, and Cortelazzo, Sergio

Subjects
*THERAPEUTICS, *MULTIPLE myeloma, *THALIDOMIDE
Abstract

The article focuses on a research which aims to evaluate the efficacy of bendamustine, dexamethasone and thalidomide in relapsed or refractory multiple myeloma patients following lenalidomide and bortezomib therapy or who were ineligible to receive such drugs as measured by the rate of response in terms of overall response rate. It also aims to assess the tolerability and toxicity and evaluate the time to treatment failure, overall survival, and disease-free survival.

Published
2019
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35. Autologous Transplantation Versus Cyclophosphamide-Lenalidomide-Prednisone Followed By Lenalidomide-Prednisone Versus Lenalidomide Maintenance in Multiple Myeloma: Long-Term Results of a Phase Ill Trial

Author

Gay, Francesca, Magarotto, Valeria, Petrucci, Maria Teresa, Di Raimondo, Francesco, Pour, Ludek, Caravita, Tommaso, Scudla, Vlastimil, Cafro, Anna Maria, Liberati, Anna Marina, Spada, Stefano, Vladimir, Maisnar, Pescosta, Norbert, Ria, Roberto, Offidani, Massimo, Bringhen, Sara, Bernardini, Annalisa, Patriarca, Francesca, Corradini, Paolo, Foa, Roberto, Cascavilla, Nicola, Catalano, Lucio, Spencer, Andrew, Roman Hajek, Boccadoro, Mario, and Palumbo, Antonio

Published
2015

36. Minimal residual disease after transplantation or lenalidomide-based consolidation in myeloma patients: a prospective analysis

Author

Oliva, Stefania, primary, Gambella, Manuela, additional, Gilestro, Milena, additional, Muccio, Vittorio Emanuele, additional, Gay, Francesca, additional, Drandi, Daniela, additional, Ferrero, Simone, additional, Passera, Roberto, additional, Pautasso, Chiara, additional, Bernardini, Annalisa, additional, Genuardi, Mariella, additional, Patriarca, Francesca, additional, Saraci, Elona, additional, Petrucci, Maria Teresa, additional, Pescosta, Norbert, additional, Liberati, Anna Marina, additional, Caravita, Tommaso, additional, Conticello, Concetta, additional, Rocci, Alberto, additional, Musto, Pellegrino, additional, Boccadoro, Mario, additional, Palumbo, Antonio, additional, and Omedè, Paola, additional

Published
2016
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37. Autologous Transplantation Versus Cyclophosphamide-Lenalidomide-Prednisone Followed By Lenalidomide-Prednisone Versus Lenalidomide Maintenance in Multiple Myeloma: Long-Term Results of a Phase III Trial

Author

Gay, Francesca, primary, Magarotto, Valeria, additional, Petrucci, Maria Teresa, additional, Di Raimondo, Francesco, additional, Pour, Luděk, additional, Caravita, Tommaso, additional, Scudla, Vlastimil, additional, Cafro, Anna Maria, additional, Liberati, Anna Marina, additional, Spada, Stefano, additional, Vladimir, Maisnar, additional, Pescosta, Norbert, additional, Ria, Roberto, additional, Offidani, Massimo, additional, Bringhen, Sara, additional, Bernardini, Annalisa, additional, Patriarca, Francesca, additional, Corradini, Paolo, additional, Foà, Roberto, additional, Cascavilla, Nicola, additional, Catalano, Lucio, additional, Spencer, Andrew, additional, Hajek, Roman, additional, Boccadoro, Mario, additional, and Palumbo, Antonio, additional

Published
2015
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38. A Randomized Study of Carfilzomib-Lenalidomide-Dexamethasone Vs Carfilzomib-Cyclophosphamide-Dexamethasone Induction in Newly Diagnosed Myeloma Patients Eligible for Transplant: High Efficacy in High- and Standard-Risk Patients

Author

Gay, Francesca Maria, Rota Scalabrini, Delia, Belotti, Angelo, Galli, Monica, Zamagni, Elena, Offidani, Massimo, Oliva, Stefania, Montefusco, Vittorio, Zambello, Renato, Ledda, Antonio, Grasso, Mariella, Aquino, Sara, Esma, Fabrizio, Tosi, Patrizia, Pisani, Francesco, Annibali, Ombretta, Liberati, Anna Marina, Baraldi, Anna, Galieni, Piero, Specchia, Giorgina, Pescosta, Norbert, Mancuso, Katia, Paris, Laura, Ribolla, Rossella, Coha, Valentina, Palumbo, Antonio, Musto, Pellegrino, Cavo, Michele, and Boccadoro, Mario

Published
2017
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39. Bortezomib-Dexamethasone Re-Treatment at Biochemical Relapse Vs Observation in Relapsed/Refractory Multiple Myeloma Patients: Results of a Phase II Multi-Center, Randomized Study

Author

Mina, Roberto, Larocca, Alessandra, Belotti, Angelo, Di Raimondo, Francesco, Baraldi, Anna, Offidani, Massimo, Marchetti, Monia, Ria, Roberto, Conconi, Annarita, Pescosta, Norbert, Grasso, Mariella, Cetani, Giusy, Cafro, Anna Maria, Passera, Roberto, Troia, Rossella, Semenzato, Gianpietro, Giuliani, Nicola, Ballanti, Stelvio, Cellini, Claudia, Liberati, Anna Marina, Caravita di Toritto, Tommaso, Petrucci, Maria Teresa, Musto, Pellegrino, Palumbo, Antonio, Sonneveld, Pieter, and Boccadoro, Mario

Published
2017
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40. Definition of a Prognostic Risk-Classifier Based on SNPs Array Analysis of Copy Number Alterations in Newly Diagnosed Transplant-Eligible Multiple Myeloma Patients

Author

Terragna, Carolina, Solli, Vincenza, Poletti, Andrea, Santacroce, Barbara, Martello, Marina, Larocca, Alessandra, Dozza, Luca, Baraldi, Anna, Pantani, Lucia, Sementa, Adelina, Tacchetti, Paola, Pescosta, Norbert, Zamagni, Elena, Leonardi, Giovanna, Musolino, Caterina, Marzocchi, Giulia, Canepa, Letizia, Ameli, Gaia, Zannetti, Beatrice, Pascarella, Anna, Borsi, Enrica, De Rosa, Luca, Testoni, Nicoletta, Martinelli, Giovanni, Sonneveld, Pieter, and Cavo, Michele

Published
2017
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41. In Multiple Myeloma, Minimal Residual Disease (MRD) Is an Early Predictor of Progression and Is Modulated By Maintenance Therapy with Lenalidomide

Author

Gambella, Manuela, primary, Omedè, Paola, additional, Oliva, Stefania, additional, Gilestro, Milena, additional, Muccio, Vittorio Emanuele, additional, Drandi, Daniela, additional, Ferrero, Simone, additional, Gay, Francesca, additional, Patriarca, Francesca, additional, Palladino, Carmela, additional, Petrucci, Maria Teresa, additional, Pescosta, Norbert, additional, Liberati, Anna Marina, additional, Caravita, Tommaso, additional, Di Raimondo, Francesco, additional, Rocci, Alberto, additional, Musto, Pellegrino, additional, Boccadoro, Mario, additional, and Palumbo, Antonio, additional

Published
2014
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43. Minimal Residual Disease Monitoring During Maintenance In Multiple Myeloma Patients

Author

Rocci, Alberto, primary, Gambella, Manuela, additional, Omedè, Paola, additional, Drandi, Daniela, additional, Gay, Francesca, additional, Patriarca, Francesca, additional, Cavallo, Federica, additional, Petrucci, Maria Teresa, additional, Tommaso, Caravita, additional, Benevolo, Giulia, additional, Pescosta, Norbert, additional, Oliva, Stefania, additional, Offidani, Massimo, additional, Montefusco, Vittorio, additional, Liberati, Anna Marina, additional, Falcone, Antonietta Pia, additional, Ballanti, Stelvio, additional, Spadano, Tonino, additional, Guglielmelli, Tommasina, additional, Musto, Pellegrino, additional, Zambello, Renato, additional, Di Raimondo, Francesco, additional, Ladetto, Marco, additional, Boccadoro, Mario, additional, and Palumbo, Antonio, additional

Published
2013
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44. Persistent Improvement In Clinical Outcomes With Bortezomib-Thalidomide-Dexamethasone Vs Thalidomide-Dexamethasone Incorporated Into Double Autologous Transplantation For Multiple Myeloma: An Updated Analysis Of Phase 3 Gimema-MMY-3006 Study

Author

Cavo, Michele, primary, Galli, Monica, additional, Pezzi, Annalisa, additional, Di Raimondo, Francesco, additional, Crippa, Claudia, additional, Offidani, Massimo, additional, Tacchetti, Paola, additional, Montefusco, Vittorio, additional, Narni, Franco, additional, Spadano, Antonio, additional, Pescosta, Norbert, additional, Zamagni, Elena, additional, Gamberi, Barbara, additional, Caravita, Tommaso, additional, Falcone, Antonietta Pia, additional, Nozzoli, Chiara, additional, Zambello, Renato, additional, Furlan, Anna, additional, Brioli, Annamaria, additional, and Boccadoro, Mario, additional

Published
2013
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45. A Simple Score, Based On Geriatric Assessment, Improves Prediction of Survival, and Risk Of Serious Adverse Events In Elderly Newly Diagnosed Multiple Myeloma Patients

Author

Larocca, Alessandra, primary, Bringhen, Sara, additional, Evangelista, Andrea, additional, Offidani, Massimo, additional, Ballanti, Stelvio, additional, Zaccaria, Alfonso, additional, Pescosta, Norbert, additional, Montefusco, Vittorio, additional, De Rosa, Luca, additional, Carella, Angelo Michele, additional, Baldini, Luca, additional, Aglietta, Massimo, additional, Vincelli, Iolanda Donatella, additional, Marasca, Roberto, additional, Pezzati, Sara, additional, Tosi, Patrizia, additional, Cocito, Federica, additional, Grasso, Mariella, additional, Fioritoni, Giuseppe, additional, Pavone, Vincenzo, additional, Musto, Pellegrino, additional, Grammatico, Sara, additional, Omedè, Paola, additional, Gay, Francesca, additional, Ciccone, Giovannino, additional, Boccadoro, Mario, additional, and Palumbo, Antonio, additional

Published
2013
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46. Bortezomib-Thalidomide-Dexamethasone Incorporated Into Autotransplantation Is Associated with More Favorable Outcomes After Relapse in Comparison with Thalidomide-Dexamethasone Plus Autotransplantation in Multiple Myeloma

Author

Cavo, Michele, primary, Galli, Monica, additional, Pantani, Lucia, additional, Di Raimondo, Francesco, additional, Crippa, Claudia, additional, Offidani, Massimo, additional, Zamagni, Elena, additional, Montefusco, Vittorio, additional, Narni, Franco, additional, Pezzi, Annalisa, additional, Spadano, Antonio, additional, Pescosta, Norbert, additional, Tacchetti, Paola, additional, Baldini, Luca, additional, Ledda, Antonio, additional, Cellini, Claudia, additional, Caravita, Tommaso, additional, Falcone, Antonietta, additional, Nozzoli, Chiara, additional, Zambello, Renato, additional, Masini, Luciano, additional, and Boccadoro, Mario, additional

Published
2012
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48. Superior Complete Response Rate (CR) and Progression-Free Survival (PFS) with Bortezomib-Thalidomide-Dexamethasone (VTD) Versus Thalidomide-Dexamethasone (TD) As Consolidation Therapy After Autologous Stem-Cell Transplantation (ASCT) in Multiple Myeloma (MM)

Author

Cavo, Michele, primary, Pantani, Lucia, additional, Patriarca, Francesca, additional, Petrucci, Maria Teresa, additional, Galli, Monica, additional, Raimondo, Francesco Di, additional, Rossi, Giuseppe, additional, Palumbo, Antonio, additional, Tacchetti, Paola, additional, Offidani, Massimo, additional, Montefusco, Vittorio, additional, Narni, Franco, additional, Spadano, Tonino, additional, Cellini, Claudia, additional, Pescosta, Norbert, additional, Baldini, Luca, additional, Ledda, Antonio, additional, Toritto, Tommaso Caravita Di, additional, Pezzi, Annalisa, additional, Falcone, Antonietta, additional, Nozzoli, Chiara, additional, Zambello, Renato, additional, Masini, Luciano, additional, Gherlinzoni, Filippo, additional, Petti, Maria Concetta, additional, Derudas, Daniele, additional, Ballanti, Stelvio, additional, Stefano, Valerio De, additional, and Baccarani, Michele, additional

Published
2011
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49. Melphalan/Prednisone/Lenalidomide (MPR) Versus High-Dose Melphalan and Autologous Transplantation (MEL200) in Newly Diagnosed Multiple Myeloma (MM) Patients <65 Years: Results of a Randomized Phase III Study

Author

Palumbo, Antonio, primary, Cavallo, Federica, additional, Hardan, Izhar, additional, Lupo, Barbara, additional, Redoglia, Valter, additional, Levin, Moshe, additional, Corradini, Paolo, additional, Pezzatti, Sara, additional, Patriarca, Francesca, additional, Cavo, Michele, additional, Marcatti, Magda, additional, Pescosta, Norbert, additional, Falcone, Antonietta Pia, additional, Ria, Roberto, additional, Rossi, Davide, additional, Benevolo, Giulia, additional, Cangialosi, Clotilde, additional, Galli, Monica, additional, Catalano, Lucio, additional, Baraldi, Anna, additional, Carella, Angelo Michele, additional, Cafro, Annamaria, additional, Siniscalchi, Agostina, additional, Crippa, Claudia, additional, Grammatico, Sara, additional, Cavalli, Maide, additional, Di Toritto, Tommaso Caravita, additional, Di Raimondo, Francesco, additional, Nagler, Arnon, additional, and Boccadoro, Mario, additional

Published
2011
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50. Aspirin, Warfarin, or Enoxaparin Thromboprophylaxis in Patients With Multiple Myeloma Treated With Thalidomide: A Phase III, Open-Label, Randomized Trial

Author

Palumbo, Antonio, primary, Cavo, Michele, additional, Bringhen, Sara, additional, Zamagni, Elena, additional, Romano, Alessandra, additional, Patriarca, Francesca, additional, Rossi, Davide, additional, Gentilini, Fabiana, additional, Crippa, Claudia, additional, Galli, Monica, additional, Nozzoli, Chiara, additional, Ria, Roberto, additional, Marasca, Roberto, additional, Montefusco, Vittorio, additional, Baldini, Luca, additional, Elice, Francesca, additional, Callea, Vincenzo, additional, Pulini, Stefano, additional, Carella, Angelo M., additional, Zambello, Renato, additional, Benevolo, Giulia, additional, Magarotto, Valeria, additional, Tacchetti, Paola, additional, Pescosta, Norbert, additional, Cellini, Claudia, additional, Polloni, Claudia, additional, Evangelista, Andrea, additional, Caravita, Tommaso, additional, Morabito, Fortunato, additional, Offidani, Massimo, additional, Tosi, Patrizia, additional, and Boccadoro, Mario, additional

Published
2011
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