16 results on '"Pescarini E"'
Search Results
2. Mast cells in melanocytic skin lesions. An immunohistochemical and quantitative study
- Author
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Dyduch, G., Krzysztof Okon, and Pescarini, E.
- Subjects
integumentary system ,pigmented nevus ,melanoma ,tryptase ,mast cells ,skin and connective tissue diseases ,neoplasms ,chymase - Abstract
The mast cells participate in inflammation and possibly in carcinogenesis. The aim of the study was to study mast cells in melanocytic lesions. The material consisted of 24 pigmented nevi, 18 dysplastic nevi and 19melanomas. The sections were stained immunohistochemically for tryptase and chymase. Positive cells were counted inside the lesions and at the interface between the lesion and dermis. The mean intralesional tryptase+count was 15.75 for nevi, 21.78 for dysplastic nevi, and 8.07 for melanomas. The chymase+intralesional count was 14.89 for nevi, 21.88 for dysplastic nevi, and 11.34 for melanomas. The tryptase+ perilesional count was 16.89 for nevi, 15.93 for dysplastic nevi, and 15.71 for melanomas. The chymase+ perilesional count was 16.52 for nevi, 16.16 for dysplastic nevi, and 14.77 for melanomas. The tryptase/chymase intralesional ratio was 0.93 for nevi, 1.05 for dysplastic nevi, and 1.67 for melanomas. The tryptase/chymase perilesional ratio was 1.02 for nevi, 1.09 for dysplastic nevi, and 1.00 for melanomas. The differences between intralesional mast cells, both tryptase+and chymase+, were statistically significant. The intralesional tryptase+ count showed an inverse correlation to age (R = –0.42); this correlation was the strongest in melanomas. The results obtained in our study suggest a possible correlation between mast cells and the pathogenesis of cutaneous melanoma.
3. Therapeutic effects of pregnancy on a chronic skin ulcer
- Author
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Lancerotto L, Lago G, Pescarini E, Bassetto F, and Vincenzo Vindigni
- Subjects
integumentary system ,Journal Article - Abstract
Objectives: Sex hormones strongly influence skin physiology and evidences suggest wound healing as well. Estrogens establish a prohealing setting, and androgens play an antagonist role. Methods and Results: We present the case of a young woman in whom pregnancy with its associated hormonal shifts allowed the spontaneous healing of a chronic wound on the left leg with bone exposure, which had followed a car accident and had resisted medical and surgical treatments for 5 years. Discussion: Systemic or topical estrogens may offer alternative options in the therapy of chronic wounds, in particular in the elderly adults who have physiologically reduced estrogens levels.
4. Body evaluation in men: the role of body weight dissatisfaction in appearance evaluation, eating, and muscle dysmorphia psychopathology.
- Author
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Dal Brun D, Pescarini E, Calonaci S, Bonello E, and Meneguzzo P
- Abstract
Background: Body image dissatisfaction is a significant concern among men, influencing appearance evaluation, eating behaviors, and muscle dysmorphia psychopathology. However, research on these correlations is notably deficient in men, largely because body image concerns are unevenly distributed between genders. Therefore, this study aims to assess the various dimensions of concerns about body image in men and explore their associations with characteristics such as sexual orientation., Methods: A cross-sectional study was conducted with 251 adult men from fitness centers in the Veneto Region, Italy. Participants completed self-report questionnaires, including the Eating Attitudes Test (EAT-26), the Appearance Schemas Inventory-Revised (ASI-R), and the Muscle Dysmorphic Disorder Inventory (MDDI). Body weight perception and dissatisfaction were evaluated using a Figure Rating Scale (FRS) with 12 male biometric silhouettes., Results: Participants were divided into three subgroups based on the experienced levels of body weight dissatisfaction: those who rated a smaller body (BWsmaller), those who rated a larger body (BWlarger) more highly relative to their own estimated body size, and those who reported implicit neutrality with their current weight (BWneu). BWsmaller participants reported higher levels of eating-related concern, while BWlarger participants exhibited higher levels of muscle dysmorphia. Additionally, the BWlarger group showed the highest degree of quantitative perceptual underestimation of their body weight. Sexual orientation was found to have an impact on body weight dissatisfaction, with bisexual men more likely to desire an increase in weight and gay men more likely to desire a decrease., Conclusions: Body weight dissatisfaction significantly impacts appearance evaluation, eating behaviors, and muscle dysmorphia psychopathology in males. Tailored interventions that consider individual differences can support the well-being of men. The study provides useful insight into male body image issues, warranting further exploration to inform effective interventions and promote positive body image and mental health in this population., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
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5. Descriptive Study of Facial Motor Cocontractions During Voluntary Facial Movement in a Healthy Population: A New Hypothesis Contributing to Synkinesis.
- Author
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Citron I, Thomson D, Pescarini E, Creasy H, Sorooshian P, Berner JE, Neville C, Kannan RY, and Nduka C
- Abstract
Background: Motor overflow refers to involuntary movements that accompany voluntary movements in healthy individuals. This may have a role in synkinesis. Objective: To describe the frequency and magnitude of facial motor overflow in a healthy population. Methodology: Healthy participants performed unilateral facial movements: brow elevation, wink, snarl, and closed smile. Two reviewers analyzed the magnitude of each movement and cocontraction. Patterns of movements are described. Univariate analysis was used to assess the relationship between efficacy of unilateral facial control and the frequency and magnitude of cocontractions. Results: Eighty-nine participants completed the videos. Consensual mirror movements occurred in 96% of participants during unilateral eye closure and 86% during brow elevation. The most common associated movement was ipsilateral eye constriction occurring during snarl (90.1%). Improved unilateral facial control was associated with a decrease in frequency and magnitude of associated movements during brow elevation, wink, and snarl. Conclusion: This study showed stereotyped patterns of motor overflow in facial muscles that resemble those in synkinesis and become more evident as unilateral control of the face decreases.
- Published
- 2022
- Full Text
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6. Targeted chemodenervation of the posterior belly of the digastric muscle for the management of jaw discomfort in facial synkinesis.
- Author
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Pescarini E, Butler DP, Perusseau-Lambert A, Nduka C, and Kannan RY
- Subjects
- Adult, Aged, Disability Evaluation, Female, Humans, Injections, Intramuscular, Male, Middle Aged, Pain Measurement, Surveys and Questionnaires, Ultrasonography, Interventional, Botulinum Toxins, Type A therapeutic use, Facial Muscles drug effects, Facial Muscles innervation, Neuromuscular Agents therapeutic use, Synkinesis drug therapy
- Abstract
Background: Botulinum toxin (BT-A) chemodenervation has been proved to significantly improve the physical and psychological well-being of patients suffering from facial synkinesis. Despite this, a cohort of patients has persistent tightness and discomfort around the angle of the jaw, which may be caused by synkinesis within the posterior belly of digastric (PBD) muscle. This study was designed to evaluate the benefits of ultrasound-guided BT-A injections into the PBD., Methods: Thirty-three patients with recalcitrant tightness and discomfort around the angle of the jaw, despite maximal facial therapy and platysmal chemodenervation were selected for inclusion. Patients underwent ultrasound-guided BT-A injection into the ipsilateral PBD muscle (skin puncture site 1 cm inferior and posterior to the angle of mandible). Outcomes consisted of the Facial Disability Index (FDI), Synkinesis Assessment Questionnaire (SAQ), and a visual analogue scale (VAS) designed to assess tightness and pain around the PBD when moving the jaw, swallowing, and masticating. Questionnaires were completed two weeks before and postinjection. Statistical analysis was performed using a paired t-test., Results: Nineteen patients completed the post-treatment outcome questionnaire. A statistically significant improvement was noted in the physical and social function aspects of the FDI and all aspects of the patient-reported VAS scores apart from tightness and pain on jaw retrusion and swallowing. There was no significant difference in the SAQ., Conclusion: This study has demonstrated the patient-perceived benefit of ultrasound-targeted BT-A chemodenervation of PBD. This represents a low-risk treatment option that can be easily added to the repertoire of treatments offered to patients with post paralysis facial synkinesis., Competing Interests: Declaration of Competing Interest Nil to declare, (Crown Copyright © 2021. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2021
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7. Late Metastatic Melanoma after 25 Years: A Case Report and a Brief Literature Review.
- Author
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Pescarini E, Spanikova G, Mbaidjol Z, De Antoni E, Vindigni V, and Bassetto F
- Abstract
The incidence of cutaneous malignant melanoma has shown a drastic increase over recent decades, and approximately 70% of newly diagnosed melanoma are tumors with a Breslow thickness less or equal to 1 mm. In the literature, there are well-documented rare cases of late metastasis of thin melanoma, and given their growing incidence, it is expected in the future to see more cases of late recurrence. We present a case report of a metastatic cutaneous melanoma 25 years from diagnosis and a review of the literature. A 61-year-old female patient presented with a newly discovered asymptomatic nodule on her thigh. Her relevant past medical history included a completely excided lesion with Breslow 1.4 mm thickness in 1989 for which she was followed up according to the guidelines and subsequently declared cured after 10 years of surveillance. Fine-needle aspiration and cytological analysis of the lesion proved to be a subcutaneous localization of malignant melanoma. The lesion was completely excised, and the patient has remained disease free since her surgery. The aim of this case report is to emphasize that late metastasis remains uncommon but a definitive cure from melanoma cannot always be considered a disease-free interval of 10 years. Physicians should always be aware of previous melanoma diagnosis with newly discovered suspicious lesions. Better patient education could improve the detection of recurrence and secondary melanomas without any need for more frequent follow-up visits and a prolonged follow-up time., Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (Copyright © 2020 Elena Pescarini et al.)
- Published
- 2020
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8. Response to the comment made on the article "The diagnostic effectiveness of dermoscopy performed by plastic surgery registrars trained in melanoma diagnosis".
- Author
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Pescarini E, De Antoni E, Azzena GP, Vindigni V, Bassetto F, and Brambullo T
- Subjects
- Dermoscopy, Humans, Melanoma, Skin Neoplasms, Surgery, Plastic
- Abstract
Competing Interests: Declaration of Competing Interest There is no conflict of interest for all of the authors.
- Published
- 2020
- Full Text
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9. Huriez syndrome associated with basal cell carcinoma. A case report.
- Author
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Grigatti M, Pescarini E, Salmaso R, Gardener C, Brambullo T, and Vindigni V
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- Aged, Female, Foot, Hand, Humans, Plastic Surgery Procedures, Carcinoma, Basal Cell complications, Carcinoma, Basal Cell diagnosis, Carcinoma, Basal Cell surgery, Keratosis diagnosis, Keratosis etiology, Keratosis surgery, Scleroderma, Localized diagnosis, Scleroderma, Localized etiology, Scleroderma, Localized surgery, Skin Neoplasms complications, Skin Neoplasms diagnosis, Skin Neoplasms etiology, Skin Neoplasms surgery
- Abstract
Huriez syndrome is a rare cancer-prone genodermatosis confined to the hands and feet connects with an increase in squamous cell carcinoma on affected skin. Its diagnosis is complex due to not well defined symptoms and since only few cases are described in literature. The differential diagnoses are many and the treatment is focused only on symptoms control and tumours eradication. Our case report is highly interesting because add new knowledge about this disease describing a new important feature of the syndrome. For the first time in literature we describe the arising of basal cell carcinoma from affected skin. KEY WORDS: H, Basal cell carcinoma, Huriez syndrome, Palmoplantar keratoderma.
- Published
- 2020
10. Diagnostic effectiveness of dermoscopy performed by plastic surgery registrars trained in melanoma diagnosis.
- Author
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Pescarini E, De Antoni E, Azzena GP, Vindigni V, and Brambullo T
- Subjects
- Humans, Retrospective Studies, Clinical Competence, Dermoscopy education, Medical Staff, Hospital, Melanoma pathology, Melanoma surgery, Skin Neoplasms pathology, Skin Neoplasms surgery, Surgery, Plastic education
- Abstract
Background: Dermoscopy improves sensitivity and specificity and helps in the early detection of melanoma and nonmelanoma skin cancers (NMSC). Because of the multidisciplinary approach to melanoma, plastic surgeons may be required to perform dermoscopy evaluation. For this reason, in some university hospitals, plastic surgeons in training might perform these evaluations. To assess the validity of digital dermoscopy conducted by plastic surgery registrars, the authors collected the diagnoses of excised lesions from a dermoscopy outpatient clinic, comparing results with literature., Methods: A total of 1094 consecutive dermoscopy evaluations performed at Padova University Hospital between 2015 and 2018 were included in the study. All examinations were carried out by 3 plastic surgery registrars who received comparable training on dermoscopy. Excised lesions were classified according to pathological reports., Results: Four hundred sixty-six lesions were excised, and of them, 224 (48%) were considered pathological or atypical lesions: 34 melanomas (15%), 83 dysplastic or uncertain significance nevi (37%), and 107 NMSC and their precursors (48%). Considering only the 347 pigmented lesions, 34% were malignant or dysplastic lesions. The number needed to treat (NNT) was 10. The nevi-to-melanoma ratio (NMR) was 8, and the malignant melanoma-to-melanoma in situ ratio (MM:MMIS ratio) was 0.36., Conclusions: This retrospective study tested the performance of specifically trained plastic surgery registrars in the detection of malignant skin lesions. Compared to literature, the analysis reflects a good sensibility for melanoma, especially in early curable stages. Moreover, our study underlines quite a high number of total excisions, which could be explained by the "surgical imprinting" of plastic surgery registrars., Competing Interests: Declaration of Competing Interest None., (Copyright © 2019 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2020
- Full Text
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11. Dermatofibrosarcoma Protuberans on Tattooed Skin: A Case Report.
- Author
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De Antoni E, Brambullo T, Pescarini E, Salmaso R, Bassetto F, and Vindigni V
- Subjects
- Adult, Female, Humans, Dermatofibrosarcoma diagnosis, Dermatofibrosarcoma surgery, Skin Neoplasms diagnosis, Skin Neoplasms surgery, Tattooing
- Abstract
Dermatofibrosarcoma protuberans is an uncommon indolent fibroblastic skin tumor with a tendency for local recurrence. Its etiology is unknown, but there may be a link with vaccination sites, burn scars, and previous skin traumas. This report describes a curious case of dermatofibrosarcoma protuberans occurring secondary to a 16-year-old tattoo.
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- 2020
- Full Text
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12. Proliferative Lesions Found at Reduction Mammaplasty: Incidence and Implications in 995 Breast Reductions.
- Author
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Pescarini E, Kohlscheen E, and Vindigni V
- Subjects
- Breast surgery, Female, Incidence, Mammaplasty
- Published
- 2019
- Full Text
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13. The Need for Routine Assessment of Masseter Function After Masseteric Nerve Harvest With the Borschel Method.
- Author
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Pescarini E, Neville C, Gwynn T, Young K, Chandrasekharan L, Nduka C, and Kannan RY
- Subjects
- Adolescent, Adult, Female, Humans, Male, Masseter Muscle diagnostic imaging, Masseter Muscle physiology, Middle Aged, Retrospective Studies, Electromyography, Facial Paralysis surgery, Magnetic Resonance Imaging, Mandibular Nerve transplantation, Masseter Muscle innervation, Nerve Transfer methods
- Published
- 2019
- Full Text
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14. Greater surgical precision of a flexible carbon dioxide laser fiber compared to monopolar electrosurgery in porcine myometrium.
- Author
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Bailey AP, Lancerotto L, Gridley C, Orgill DP, Nguyen H, Pescarini E, Lago G, and Gargiulo AR
- Subjects
- Animals, Electrosurgery adverse effects, Female, Laser Therapy adverse effects, Sus scrofa, Swine, Tissue Adhesions, Wound Healing, Electrosurgery methods, Hysterectomy methods, Laser Therapy methods, Lasers, Gas, Myometrium injuries, Myometrium surgery
- Abstract
The objective of this experimental animal study was to compare the surgical precision of a flexible CO2 laser fiber with that of monopolar electrosurgery in porcine myometrium. The subjects were 6 live adult non-pregnant female pigs. Linear injury to the uterine horns was created using a flexible CO2 laser fiber at 5W, 10W, and 15W and with monopolar electrosurgery at 10W, 20W, 30W, and 40W in both cut and coagulation modes. Hysterectomy was then performed in the live animals. Cross-sections of the tissue were processed and stained using Masson trichrome to differentiate damaged from undamaged myometrium. Measurement means were compared using analysis of variance with Tukey honest significant difference correction; p <.05 indicated significance. Incision width of the laser at 5W and 10W was significantly less than both monopolar coagulation at all power settings and monopolar cut at 30W and 40W (all p <.01), at 5W was also significantly less than monopolar cut at 10W (p = .03), and at 15W was significantly less than monopolar coagulation at 40W (p = .001). Incision depth of the laser at 5W was significantly less than monopolar coagulation at 40W and laser at 15W (both p = .01), at 15W was significantly greater than monopolar coagulation at 10W and monopolar cut at 10, 20, and 30W (p ≤.01), and increased proportional to power for all 3 energy types. Collateral thermal damage width at all laser power settings was significantly less than at all monopolar coagulation power settings (p ≤.04) with the exception of the laser at 15W compared with monopolar coagulation at 10W (p = .30), and at all laser power settings was significantly less than at all monopolar coagulation power settings (p <.001). Collateral thermal damage depth of the laser at 5W and 10W was significantly less than monopolar cut at 30W (p ≤.002) and increased proportional to power in monopolar coagulation mode but remained constant with the laser. Incising efficiency of the laser at 5W was significantly greater than monopolar coagulation at 10W (p = .04), at 10W was significantly greater than at all monopolar power settings (p ≤.007) except cut at 40W (p = .29), and at 15W was significantly greater than that of every other energy type and power setting tested (p ≤.04). These findings support the hypothesis that CO2 laser energy delivered via a flexible fiber system would exhibit greater surgical precision than monopolar electrosurgery, in both cut and coagulation modes, as defined by 3 parameters: incising efficiency, changes in incision depth compared with width as power increases, and variability in the resulting incision measurements. Because increased thermal damage has been associated with delayed tissue necrosis and adhesion formation, these findings prompt the design of a comparative survival animal study to assess additional clinically relevant parameters., (Copyright © 2014 AAGL. Published by Elsevier Inc. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
15. Therapeutic effects of pregnancy on a chronic skin ulcer.
- Author
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Lancerotto L, Lago G, Pescarini E, Bassetto F, and Vindigni V
- Abstract
Objectives: Sex hormones strongly influence skin physiology and evidences suggest wound healing as well. Estrogens establish a prohealing setting, and androgens play an antagonist role., Methods and Results: We present the case of a young woman in whom pregnancy with its associated hormonal shifts allowed the spontaneous healing of a chronic wound on the left leg with bone exposure, which had followed a car accident and had resisted medical and surgical treatments for 5 years., Discussion: Systemic or topical estrogens may offer alternative options in the therapy of chronic wounds, in particular in the elderly adults who have physiologically reduced estrogens levels.
- Published
- 2013
16. Mast cells in melanocytic skin lesions. An immunohistochemical and quantitative study.
- Author
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Dyduch G, Okoń K, and Pescarini E
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor metabolism, Cell Count, Child, Chymases metabolism, Dysplastic Nevus Syndrome enzymology, Female, Humans, Male, Mast Cells enzymology, Melanocytes enzymology, Melanoma enzymology, Middle Aged, Nevus, Pigmented enzymology, Skin Neoplasms enzymology, Tryptases metabolism, Young Adult, Dysplastic Nevus Syndrome pathology, Mast Cells pathology, Melanocytes pathology, Melanoma pathology, Nevus, Pigmented pathology, Skin Neoplasms pathology
- Abstract
The mast cells participate in inflammation and possibly in carcinogenesis. The aim of the study was to study mast cells in melanocytic lesions. The material consisted of 24 pigmented nevi, 18 dysplastic nevi and 19 melanomas. The sections were stained immunohistochemically for tryptase and chymase. Positive cells were counted inside the lesions and at the interface between the lesion and dermis. The mean intralesional tryptase+ count was 15.75 for nevi, 21.78 for dysplastic nevi, and 8.07 for melanomas. The chymase+ intralesional count was 14.89 for nevi, 21.88 for dysplastic nevi, and 11.34 for melanomas. The tryptase+ perilesional count was 16.89 for nevi, 15.93 for dysplastic nevi, and 15.71 for melanomas. The chymase+ perilesional count was 16.52 for nevi, 16.16 for dysplastic nevi, and 14.77 for melanomas. The tryptase/chymase intralesional ratio was 0.93 for nevi, 1.05 for dysplastic nevi, and 1.67 for melanomas. The tryptase/chymase perilesional ratio was 1.02 for nevi, 1.09 for dysplastic nevi, and 1.00 for melanomas. The differences between intralesional mast cells, both tryptase+ and chymase+, were statistically significant. The intralesional tryptase+ count showed an inverse correlation to age (R = -0.42); this correlation was the strongest in melanomas. The results obtained in our study suggest a possible correlation between mast cells and the pathogenesis of cutaneous melanoma.
- Published
- 2011
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