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Your search keyword '"Peruzzaro, Sarah"' showing total 9 results
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9 results on '"Peruzzaro, Sarah"'

1. A Mixed-Surface Polyamidoamine Dendrimer for In Vitro and In Vivo Delivery of Large Plasmids

Author

Srinageshwar, Bhairavi, primary, Florendo, Maria, additional, Clark, Brittany, additional, Johnson, Kayla, additional, Munro, Nikolas, additional, Peruzzaro, Sarah, additional, Antcliff, Aaron, additional, Andrews, Melissa, additional, Figacz, Alexander, additional, Swanson, Douglas, additional, Dunbar, Gary L., additional, Sharma, Ajit, additional, and Rossignol, Julien, additional

Published
2020
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5. PAMAM Dendrimers Cross the Blood–Brain Barrier When Administered through the Carotid Artery in C57BL/6J Mice

Author

Srinageshwar, Bhairavi, primary, Peruzzaro, Sarah, additional, Andrews, Melissa, additional, Johnson, Kayla, additional, Hietpas, Allison, additional, Clark, Brittany, additional, McGuire, Crystal, additional, Petersen, Eric, additional, Kippe, Jordyn, additional, Stewart, Andrew, additional, Lossia, Olivia, additional, Al-Gharaibeh, Abeer, additional, Antcliff, Aaron, additional, Culver, Rebecca, additional, Swanson, Douglas, additional, Dunbar, Gary, additional, Sharma, Ajit, additional, and Rossignol, Julien, additional

Published
2017
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9. Electrophysiological, behavioral and histological characterization of paclitaxel, cisplatin, vincristine and bortezomib-induced neuropathy in C57Bl/6 mice

Author

Boehmerle, Wolfgang, Huehnchen, Petra, Peruzzaro, Sarah, Balkaya, Mustafa, and Endres, Matthias

Abstract

Polyneuropathy is a frequent and potentially severe side effect of clinical tumor chemotherapy. The goal of this study was to characterize paclitaxel-, cisplatin-, vincristine- and bortezomib-induced neuropathy in C57BL/6 mice with a comparative approach. The phenotype of the animals was evaluated at four time points with behavioral and electrophysiological tests, followed by histology. Treatment protocols used in this study were well tolerated and induced a sensory and predominantly axonal polyneuropathy. Behavioral testing revealed normal motor coordination, whereas all mice receiving verum treatment developed mechanical allodynia and distinct gait alterations. Electrophysiological evaluation showed a significant decrease of the caudal sensory nerve action potential amplitude for all cytostatic agents and a moderate reduction of nerve conduction velocity for cisplatin and paclitaxel. This finding was confirmed by histological analysis of the sciatic nerve which showed predominantly axonal damage: Paclitaxel and vincristine affected mostly large myelinated fibers, bortezomib small myelinated fibers and cisplatin damaged all types of myelinated fibers to a similar degree. Neuropathic symptoms developed faster in paclitaxel and vincristine treated animals compared to cisplatin and bortezomib treatment. The animal models in this study can be used to elucidate pathomechanisms underlying chemotherapy-induced polyneuropathy and for the development of novel therapeutic and preventative strategies.

Published
2014
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