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1. Clinical effectiveness and analytical quality of a national pointof-care testing network for sexually transmitted infections integrated into rural and remote primary care clinics in Australia, 2016 - 2022: an observational program evaluation

Author

Causer, LM, Ward, J, Smith, K, Saha, A, Andrewartha, K, Wand, H, Hengel, B, Badman, SG, Tangey, A, Matthews, S, Mak, D, Gunathilake, M, Moore, E, Speers, D, Persing, D, Anderson, D, Whiley, D, Maher, L, Regan, D, Donovan, B, Fairley, C, Kaldor, J, Shephard, M, Guy, R, Causer, LM, Ward, J, Smith, K, Saha, A, Andrewartha, K, Wand, H, Hengel, B, Badman, SG, Tangey, A, Matthews, S, Mak, D, Gunathilake, M, Moore, E, Speers, D, Persing, D, Anderson, D, Whiley, D, Maher, L, Regan, D, Donovan, B, Fairley, C, Kaldor, J, Shephard, M, and Guy, R

Abstract

BACKGROUND: To address inequitable diagnostic access and improve time-to-treatment for First Nations peoples, molecular point-of-care (POC) testing for chlamydia, gonorrhoea and trichomonas was integrated into 49 primary care clinics across Australia. We conducted an observational evaluation to determine clinical effectiveness and analytical quality of POC testing delivered through this national program. METHODS: We evaluated (i) implementation by measuring trends in mean monthly POC testing; ii) clinical effectiveness by comparing proportions of positive patients treated by historical control/intervention period and by test type, and calculated infectious days averted; (iii) analytical quality by calculating result concordance by test type, and proportion of unsuccessful POC tests. FINDINGS: Between 2016 and 2022, 46,153 POC tests were performed; an increasing mean monthly testing trend was observed in the first four years (p < 0.0001). A greater proportion of chlamydia/gonorrhoea positives were treated in intervention compared with historical control periods (≤2 days: 37% vs 22% [RR 1.68; 95% CI 1.12, 2.53]; ≤7 days: 48% vs 30% [RR 1.6; 95% CI 1.10, 2.33]; ≤120 days: 79% vs 54% [RR 1.46; 95% CI 1.10, 1.95]); similarly for trichomonas positives and by test type. POC testing for chlamydia, gonorrhoea and trichomonas averted 4930, 5620 and 7075 infectious days, respectively. Results concordance was high [99.0% (chlamydia), 99.3% (gonorrhoea) and 98.9% (trichomonas)]; unsuccessful POC test proportion was 1.8% for chlamydia/gonorrhoea and 2.1% for trichomonas. INTERPRETATION: Molecular POC testing was successfully integrated into primary care settings as part of a routinely implemented program achieving significant clinical benefits with high analytical quality. In addition to the individual health benefits of earlier treatment, fewer infective days could contribute to reduced transmissions in First Nations communities. FUNDING: This work was supported by an Australian

Published
2024

15. Focusing on the selection process: a field study of the measures that influence admission decisions

Author

Russell, James S., Persing, D. Lynne, Dunn, Judith A., and Rankin, Richard J.

Subjects
Ranking and selection (Statistics) -- Methods, Elementary school teachers -- Appointments, resignations and dismissals, Student teachers -- Appointments, resignations and dismissals, Education, Psychology and mental health
Abstract

This field study examines the measures used at multiple stages in a selection process employed by a university's teacher training program. Specifically, the study utilizes LISREL structural analysis to assess the importance each measure assumed in determining admission and intermediate outcomes. Of the measures, which included ability tests and a situational interview, only the mathematics, language, and essay scores prophesied selection. Neither the pre-interview overall qualifications rating nor the interview score proved significant in predicting admission, suggesting a discrepancy between official and operative emphases. Age and race emerged as non-significant, and sex as of minor importance. An analysis of the results supports the position that demographic variables should be investigated in field settings in which raters possess substantial pertinent applicant information. The study concludes with a discussion of the need to elevate the level of analysis in selection research in order to understand the nature and validity of decisions made during the process itself.

Published
1990

17. Evaluation of the Xpert fingerstick HCV viral load assay

Author

Lamoury, F., primary, Bajis, S., additional, Hajarizadeh, B., additional, Marshall, A., additional, Martinello, M., additional, Ivanova, E., additional, Catlett, B., additional, Mowat, Y., additional, Marks, P., additional, Amin, J., additional, Smith, J., additional, Ezard, N., additional, Cock, V., additional, Hayllar, J., additional, Persing, D., additional, Kleman, M., additional, Cunningham, P., additional, Dore, G., additional, Applegate, T., additional, and Grebely, J., additional

Published
2018
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18. Evaluation of the Xpert HCV Viral Load point-of-care assay from venepuncture-collected and finger-stick capillary whole-blood samples: a cohort study

Author

Grebely, J, Lamoury, FMJ, Hajarizadeh, B, Mowat, Y, Marshall, AD, Bajis, S, Marks, P, Amin, J, Smith, J, Edwards, M, Gorton, C, Ezard, N, Persing, D, Kleman, M, Cunningham, P, Catlett, B, Dore, GJ, Applegate, TL, Grebely, J, Lamoury, FMJ, Hajarizadeh, B, Mowat, Y, Marshall, AD, Bajis, S, Marks, P, Amin, J, Smith, J, Edwards, M, Gorton, C, Ezard, N, Persing, D, Kleman, M, Cunningham, P, Catlett, B, Dore, GJ, and Applegate, TL

Abstract

Background Point-of-care hepatitis C virus (HCV) RNA testing offers an advantage over antibody testing (which only indicates previous exposure), enabling diagnosis of active infection in a single visit. In this study, we evaluated the performance of the Xpert HCV Viral Load assay with venepuncture and finger-stick capillary whole-blood samples. Methods Plasma and finger-stick capillary whole-blood samples were collected from participants in an observational cohort enrolled at five sites in Australia (three drug and alcohol clinics, one homelessness service, and one needle and syringe programme). We compared the sensitivity and specificity of the Xpert HCV Viral Load test for HCV RNA detection by venepuncture and finger-stick collection with the Abbott RealTime HCV Viral Load assay (gold standard). Findings Of 210 participants enrolled between Feb 8, 2016, and July 27, 2016, 150 participants had viral load testing results for the three assays tested. HCV RNA was detected in 45 (30% [95% CI 23–38]) of 150 participants based on Abbott RealTime. Sensitivity of the Xpert HCV Viral Load assay for HCV RNA detection in plasma collected by venepuncture was 100·0% (95% CI 92·0–100·0) and specificity was 99·1% (95% CI 94·9–100·0). Sensitivity of the Xpert HCV Viral Load assay for HCV RNA detection in samples collected by finger-stick was 95·5% (95% CI 84·5–99·4) and specificity was 98·1% (95% CI 93·4–99·8). No adverse events caused by the index test or the reference standard were observed. Implications The Xpert HCV Viral Load test can detect active infection from a finger-stick sample, which represents an advance over antibody-based tests that only indicate past or previous exposure. Funding National Health and Medical Research Council (Australia), Cepheid, South Eastern Sydney Local Health District (Australia), and Merck Sharp & Dohme (Australia).

Published
2017

19. Field evaluation of Xpert ® HCV Viral Load point-of-care test for detection of hepatitis C virus infection by venipuncture-collected and finger-stick capillary whole-blood samples

Author

Grebely, J., primary, Lamoury, F., additional, Hajarizadeh, B., additional, Mowat, Y., additional, Marshall, A., additional, Bajis, S., additional, Marks, P., additional, Amin, J., additional, Smith, J., additional, Edwards, M., additional, Gorton, C., additional, Ezard, N., additional, Persing, D., additional, Kleman, M., additional, Cunningham, P., additional, Catlett, B., additional, Dore, G., additional, and Applegate, T.L., additional

Published
2017
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23. Identification of pan B-cell neoplasm markers using a combination of cDNA subtraction and microarrayanalysis

Author

Gaiger, A., Ordonez, N., Mannion-Henderson, J., Carter, L., Kušec, R., Jakšić, Branimir, Greinix, H., Jeffery, E., Jelinek, D., Greipp, P., Persing, D., Cheever, M.A., Jaeger, Ulrich, and Algate, P.

Subjects
musculoskeletal, neural, and ocular physiology, digestive, oral, and skin physiology, B-cell neoplasm, markers, cDNA, microarray, human activities, behavioral disciplines and activities, psychological phenomena and processes
Abstract

Identification of pan B-cell neoplasm markers using a combination of cDNA subtraction and microarrayanalysis.

Published
2003

24. Identification of genes associated with multiple myeloma and monoclonal gammopathy of undetermined significance using the myeloma microarray

Author

Gaiger, A., Fonseca, R., Jelinek, D., Ordonez, N., Pyle, R., Molesh, D., Jeffery, E., Likes, R., Lechner, K., Kušec, Rajko, Jaeger, Ulrich, Persing, D., and Greipp, P.

Subjects
immune system diseases, hemic and lymphatic diseases, multiple myeloma, microarray, monoclonal gammopathy
Abstract

Identification of genes associated with multiple myeloma and monoclonal gammopathy of undetermined significance using the myeloma microarray.

Published
2003

25. Identification of pan B-cell neoplasm markers using a combination of cDNA PCR subtraction and microarray analysis

Author

Gaiger, A., Ordonez, N., Mannion-Henderson, J., Carter, L., Kusec, Rajko, Jaksic, Branimir, Jaeger, U., Greinix, H., McNeill, P., Jeffery, E., Reed, S., Jelinek, D., Greipp, P., Persing, D., Cheever, M.A., and Algate, P.

Subjects
hemic and lymphatic diseases
Abstract

Malignant cells express multiple antigens that can be recognized by the immune system and can be targeted by antigen specific immunotherapies including vaccines, antibodies and T cells. To identify genes that are over-expressed in B-cell malignancies PCR subtracted cDNA libraries in conjunction with microarray screening were used. Ten subtracted libraries (lymphoma n=6, CLL n=2, myeloma n=2) were constructed to enrich for B-cell neoplasm or lymphatic tissue specific cDNA sequences. cDNA pools from lymphomas, B-CLL and multiple myeloma (MM) were subtracted against cDNA pools of related normal hematopoietic tissues or normal non-hematopietic tissues. Subtracted libraries showed enrichment for both B-cell neoplasm and lymphatic tissue specific genes compared to an unsubtracted library. 14, 000 clones were sequenced and analyzed by comparison to sequences in 3 electronic databases: GenBank, huEST and GenSeq. At the time of analysis, 1380 (10%) clones had no significant similarities to known genes and 12, 120 (90%) matched known genes. These 14, 000 cDNA fragments were then analyzed using DNA microarray technology. Genes over-expressed in B-cell malignancies were identified using pairs of fluorescence-labeled cDNA probes synthesized from lymphomas, CLL or MM (n=50) and normal tissue poly A+ RNAs (n=50). Over 1.4 Million hybridization signals were analyzed. Expression patterns of 65 overexpressed genes were confirmed and characterized further by Real Time PCR using a panel of 170 cDNAs comprising of lymphomas, CLL, MM, normal tissues and MACS sorted hematopoietic subpopulations. Expression profiles were compared to known therapeutic antibody targets, CD20, CD52 and CD45. Based on their mRNA expression profile a group of cDNA fragments (Ly1448, Ly1456 and Ly1464) was identified demonstrating expression in normal tissues similar to CD20 but displaying broader coverage in B-cell malignancies. These cDNA fragments are expressed in the majority of B-cell lymphomas, B-CLL and multiple myeloma patient samples and were thus termed Pan B-cell neoplasm markers. So far, potential full length open reading frames of 2 of the 3 cDNA fragments have been identified, encoding for proteins with a predicted transmembrane region. Further characterization of these genes is in progress.

Published
2001

27. Relationship of human papillomavirus to Schneiderian papillomas.

Author

Weiner JS, Sherris D, Kasperbauer J, Lewis J, Li H, Persing D, Weiner, J S, Sherris, D, Kasperbauer, J, Lewis, J, Li, H, and Persing, D

Abstract

Objectives/hypothesis: To classify a large group of Schneiderian papillomas (SPs) into their histologic subtypes and to determine the incidence of human papillomavirus (HPV) in each subtype.Study Design: Pathologic review and polymerase chain reaction-based (PCR-based) examination of archived tissue.Methods: Slides of 114 tumors diagnosed as Schneiderian, inverting, fungiform, or cylindric cell papillomas, or any associated carcinomas, were examined by a head and neck pathologist. Using PCR, consensus primers for the L1 region of HPV were used to determine the presence of HPV in the tumors. This was also performed on normal turbinate control specimens.Results: Eighty-two (78%) were the inverting subtype, 21 (20%) the fungiform subtype, and 2 (2%) the cylindric cell type. Nine tumors were diagnosed as either verrucous or squamous cell carcinoma. Eighty-eight percent of the tumors had DNA of sufficient quality to be amplified using PCR. Of these, 5 of 69 (6.8%) inverting, 17 of 17 (100%) fungiform, and 0 of 2 cylindric cell papillomas were positive for HPV. One of nine (11.1%) cancers was positive for HPV. No normal turbinate tissue contained HPV. HPV types 6b and 11 accounted for all cases of fungiform papillomas. Of the five HPV-positive inverting papillomas, three had HPV type 11 and two had HPV type 16. The single carcinoma containing HPV contained HPV type 18.Conclusions: The histologic subtype of SPs is important, as their etiologies appear to be different. HPV 6b and 11 appear to be involved in all cases of fungiform papillomas but are only rarely involved in cases of inverting or cylindric cell papillomas. HPV 16 may rarely play a role in cases of inverting papillomas, and HPV 16 and 18 may be involved in a subset of cases of carcinomas originating in an inverting papilloma. [ABSTRACT FROM AUTHOR]

Published
1999

38. Managing in polychronic times: exploring individual creativity and performance in intellectually intensive venues

Author

Persing, D. Lynne

Subjects
Creative ability -- Management, Human resource management -- Research, Time management -- Research, Business, Business, general, Human resources and labor relations, Psychology and mental health
Abstract

The increase in competitive pressures has made polychronicity a trend among firms that try to achieve more with less at a greater speed with their employees. By polychronicity is meant the performance of two or more things simultaneously. Polychronic behavior is brought about by several factors. These include downsizing, using teams and pushing the time to market. With regard to polychronicity's role in creativity, research has suggested that individual creativity is more related to polychronicity than to monochronicity.

Published
1999

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