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1. Association between procedural time and outcome in unsuccessful mechanical thrombectomy for acute ischemic stroke: analysis from the Italian Registry of Endovascular Treatment in Acute Stroke

Author

Sallustio, Fabrizio, Nicolini, Ettore, Saia, Valentina, Pracucci, Giovanni, Mascolo, Alfredo Paolo, Marrama, Federico, Gandini, Roberto, Da Ros, Valerio, Diomedi, Marina, Alemseged, Fana, Casetta, Ilaria, Fainardi, Enrico, Castellan, Lucio, Del Sette, Massimo, Limbucci, Nicola, Nencini, Patrizia, Bergui, Mauro, Cerrato, Paolo, Saletti, Andrea, De Vito, Alessandro, Cioni, Samuele, Tassi, Rossana, Simonetti, Luigi, Zini, Andrea, Ruggiero, Maria, Longoni, Marco, Tessitore, Agostino, Ferraù, Ludovica, Cavasin, Nicola, Critelli, Adriana, Vallone, Stefano, Bigliardi, Guido, Zimatore, Domenico Sergio, Petruzzellis, Marco, Boghi, Andrea, Naldi, Andrea, Comai, Alessio, Dall’Ora, Elisa, Sanfilippo, Giuseppina, Persico, Alessandra, Gallesio, Ivan, Sepe, Federica, Menozzi, Roberto, Pezzini, Alessandro, Besana, Michele, Giossi, Alessia, Sanna, Antioco, Tassinari, Tiziana, Burdi, Nicola, Boero, Giovanni, Augelli, Raffaele, Cappellari, Manuel, Cosottini, Mirco, Giannini, Nicola, Romano, Daniele G., Frauenfelder, Giulia, Nuzzi, Paolo Nunzio, Spinelli, Maria Carmela, Paladini, Adriana, Rizzo, Annalisa, Filizzolo, Marco, Mannino, Marina, Timpani, Carmine, De Santis, Federica, Carità, Giuseppe, Russo, Monia, Galvano, Gianluca, Sicurella, Luigi, Mangiafico, Salvatore, and Toni, Danilo

Published
2024
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2. Carotid artery stenting during endovascular thrombectomy for acute ischemic stroke with tandem occlusion: the Italian Registry of Endovascular Treatment in Acute Stroke

Author

Sallustio, Fabrizio, Pracucci, Giovanni, Cappellari, Manuel, Saia, Valentina, Mascolo, Alfredo Paolo, Marrama, Federico, Gandini, Roberto, Koch, Giacomo, Diomedi, Marina, D’Agostino, Federica, Rocco, Alessandro, Da Ros, Valerio, Wlderk, Andrea, Nezzo, Marco, Argirò, Renato, Morosetti, Daniele, Renieri, Leonardo, Nencini, Patrizia, Vallone, Stefano, Zini, Andrea, Bigliardi, Guido, Pitrone, Antonio, Grillo, Francesco, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Naldi, Andrea, Carità, Giuseppe, Casetta, Ilaria, Gasparotti, Roberto, Magoni, Mauro, Simonetti, Luigi, Haznedari, Nicolò, Paolucci, Matteo, Mavilio, Nicola, Malfatto, Laura, Menozzi, Roberto, Genovese, Antonio, Cosottini, Mirco, Orlandi, Giovanni, Comai, Alessio, Franchini, Enrica, Pedicelli, Alessandro, Frisullo, Giovanni, Puglielli, Edoardo, Casalena, Alfonsina, Cester, Giacomo, Baracchini, Claudio, Castellano, Davide, Di Liberto, Alessandra, Ricciardi, Giuseppe Kenneth, Chiumarulo, Luigi, Petruzzellis, Marco, Lafe, Elvis, Persico, Alessandra, Cavasin, Nicola, Critelli, Adriana, Semeraro, Vittorio, Tinelli, Angelica, Giorgianni, Andrea, Carimati, Federico, Auteri, William, Rizzuto, Stefano, Biraschi, Francesco, Nicolini, Ettore, Ferrari, Antonio, Melis, Maurizio, Calia, Stefano, Tassinari, Tiziana, Nuzzi, Nunzio Paolo, Corato, Manuel, Sacco, Simona, Squassina, Guido, Invernizzi, Paolo, Gallesio, Ivan, Ruiz, Luigi, Dui, Giovanni, Carboni, Nicola, Amistà, Pietro, Russo, Monia, Maiore, Mario, Zanda, Bastianina, Craparo, Giuseppe, Mannino, Marina, Inzitari, Domenico, Toni, Danilo, and Mangiafico, Salvatore

Published
2023
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3. Association of the careggi collateral score with radiological outcomes after thrombectomy for stroke with an occlusion of the middle cerebral artery

Author

Cappellari, Manuel, Saia, Valentina, Pracucci, Giovanni, Fainardi, Enrico, Nencini, Patrizia, Malfatto, Laura, Tassi, Rossana, Cerrato, Paolo, Mancuso, Michelangelo, Pesare, Angela, La Spina, Paolino, Lotti, Enrico Maria, Casalena, Alfonsina, Petruzzellis, Marco, Baracchini, Claudio, Via, Alessandra Giai, Gaudiano, Carmen, Sallustio, Fabrizio, Tassinari, Tiziana, Critelli, Adriana, Melis, Maurizio, Persico, Alessandra, Casetta, Ilaria, Sacco, Simona, Ferrandi, Delfina, Marcheselli, Simona, Russo, Monia, Zivelonghi, Cecilia, Mandruzzato, Nicolò, Invernizzi, Paolo, Romano, Daniele, Nicolini, Ettore, Scoditti, Umberto, Magoni, Mauro, Cariddi, Lucia Princiotta, Vallone, Stefano, Inzitari, Domenico, Toni, Danilo, and Mangiafico, Salavatore

Published
2022
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12. Carotid artery stenting during endovascular thrombectomy for acute ischemic stroke with tandem occlusion: the Italian Registry of Endovascular Treatment in Acute Stroke

Author

Sallustio, Fabrizio, Pracucci, Giovanni, Cappellari, Manuel, Saia, Valentina, Mascolo, Alfredo Paolo, Marrama, Federico, Gandini, Roberto, Koch, Giacomo, Diomedi, Marina, D’Agostino, Federica, Rocco, Alessandro, Da Ros, Valerio, Wlderk, Andrea, Nezzo, Marco, Argirò, Renato, Morosetti, Daniele, Renieri, Leonardo, Nencini, Patrizia, Vallone, Stefano, Zini, Andrea, Bigliardi, Guido, Pitrone, Antonio, Grillo, Francesco, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Naldi, Andrea, Carità, Giuseppe, Casetta, Ilaria, Gasparotti, Roberto, Magoni, Mauro, Simonetti, Luigi, Haznedari, Nicolò, Paolucci, Matteo, Mavilio, Nicola, Malfatto, Laura, Menozzi, Roberto, Genovese, Antonio, Cosottini, Mirco, Orlandi, Giovanni, Comai, Alessio, Franchini, Enrica, Pedicelli, Alessandro, Frisullo, Giovanni, Puglielli, Edoardo, Casalena, Alfonsina, Cester, Giacomo, Baracchini, Claudio, Castellano, Davide, Di Liberto, Alessandra, Ricciardi, Giuseppe Kenneth, Chiumarulo, Luigi, Petruzzellis, Marco, Lafe, Elvis, Persico, Alessandra, Cavasin, Nicola, Critelli, Adriana, Semeraro, Vittorio, Tinelli, Angelica, Giorgianni, Andrea, Carimati, Federico, Auteri, William, Rizzuto, Stefano, Biraschi, Francesco, Nicolini, Ettore, Ferrari, Antonio, Melis, Maurizio, Calia, Stefano, Tassinari, Tiziana, Nuzzi, Nunzio Paolo, Corato, Manuel, Sacco, Simona, Squassina, Guido, Invernizzi, Paolo, Gallesio, Ivan, Ruiz, Luigi, Dui, Giovanni, Carboni, Nicola, Amistà, Pietro, Russo, Monia, Maiore, Mario, Zanda, Bastianina, Craparo, Giuseppe, Mannino, Marina, Inzitari, Domenico, Toni, Danilo, Mangiafico, Salvatore, Gasparotti, R., Inzitari, D., Mangiafico, S., Toni, D., Vallone, S., Zini, A., Bergui, M., Causin, F., Ciccone, A., Nencini, P., Saletti, A., Sallustio, F., Tassi, R., Thyrion, F. Zappoli, Pracucci, G., Saia, V., Gandini, R., Da Ros, V., Greco, L., Morosetti, D., Diomedi, M., Nappini, S., Limbucci, N., Renieri, L., Fainardi, E., Verganti, L., Sacchetti, F., Zelent, G., Bigliardi, G., Dell’Acqua, M. L., Picchetto, L., Vandelli, L., Pentore, R., Maffei, S., Nichelli, P., Longo, M., Pitrone, A., Vinci, S. L., Velo, M., Caragliano, A., Tessitore, A., Bonomo, O., Musolino, R., La Spina, P., Casella, C., Fazio, M. C., Grillo, F., Cotroneo, M., Dell’Aera, C., Francalanza, I., Bracco, S., Cioni, S., Gennari, P., Vallone, I. M., Cerase, A., Martini, G., Stura, G., Daniele, D., Cerrato, P., Naldi, A., Onofrio, M., De Vito, A., Azzini, C., Casetta, I., Mardighian, D., Frigerio, M., Magoni, M., Costa, A., Simonetti, L., Cirillo, L., Taglialatela, F., Isceri, S., Princiotta, C., Dall’Olio, M., Cellerini, M., Gentile, M., Piccolo, L., Migliaccio, L., Brancaleoni, L., Naldi, F., Romoli, M., Zaniboni, A., Ruggiero, M., Sanna, A., Haznedari, N., Commodaro, C., Longoni, M., Biguzzi, S., Cordici, F., Malatesta, E., Castellan, L., Mavilio, N., Salsano, G., Malfatto, L., Finocchi, C., Menozzi, R., Piazza, P., Epifani, E., Andreone, A., Scoditti, U., Castellini, P., Latte, L., Grisendi, I., Cosottini, M., Puglioli, M., Lazzarotti, G., Lauretti, D., Mancuso, M., Giannini, N., Maccarone, M., Orlandi, G., Comai, A., Bonatti, G., Nano, G., Ferro, F., Bonatti, M., Dall’Ora, E., Dossi, R. Currò, Turri, E., Turri, M., Colosimo, C., Pedicelli, A., D’Argento, F., Alexandre, A., Frisullo, G., Di Egidio, V., Puglielli, E. G., Ruggero, L., Assetta, M., Casalena, A., Cester, G., Baracchini, C., Viaro, F., Pieroni, A., Vaudano, G., Comelli, C., Di Maggio, L., Castellano, D., Cavallo, R., Duc, E., Chianale, G., Ciceri, E. F. M., Plebani, M., Augelli, R., Zampieri, P., Grazioli, A., Cappellari, M., Forlivesi, S., Tomelleri, G., Micheletti, N., Chiumarulo, L., Zimatore, D. S., Federico, F., Petruzzelli, M., Zappoli, F., Lafe, E., Sanfilippo, G., Sgreccia, A., Martignoni, A., Cavallini, A., Denaro, F., Persico, A., Cagliari, E., Cavasin, N., Quatrale, R., Critelli, A., Burdi, N., Semeraro, V., Lucarelli, N., Ganimede, M. P., Internò, S., Tinelli, A., Prontera, M. P., Pesare, A., Cotroneo, E., Pampana, E., Ricciardi, F., Gigli, R., Pezzella, F. R., Corsi, F., Giorgianni, A., Baruzzi, F., Pellegrino, C., Terrana, A., Versino, M., Delodovici, M. L., Carimati, F., Cariddi, L. Princiotta, Auteri, W., Di Benedetto, O., Silvagni, U., Perrotta, P., Crispino, E., Petrone, A., Stancati, F., Rizzuto, S., Pugliese, P., Pisani, E., Siniscalchi, A., Gaudiano, C., Pirritano, D., Del Giudice, F., Piano, M., Agostoni, E., Motto, C., Gatti, A., Guccione, A., Tortorella, R., Stecco, A., Guzzardi, G., Del Sette, B., Coppo, L., Baldan, J., Romano, D., Siani, A., Locatelli, G., Saponiero, R., Napolitano, R., De Gregorio, M., Volpe, G., Tenuta, M., Guidetti, G., Biraschi, F., Wulbek, A., Falcou, A., Anzini, A., Mancini, A., De Michele, M., Fausti, S., Di Mascio, M. T., Durastanti, L., Sbardella, E., Mellina, V., Nicolini, E., Comelli, S., Ganau, C., Corraine, S., Fusaro, F., Ferrari, A., Schirru, F., Ledda, V., Secci, S., Melis, M., Piras, V., Moller, J., Padolecchia, R., Allegretti, L., Caldiera, V., Calia, S., Ganci, G., Tassinari, T., Sugo, A., De Nicola, M., Giannoni, M., Bruni, S., Gambelli, E., Provinciali, L., Nuzzi, N. P., Marcheselli, S., Corato, M., Scomazzoni, F., Simionato, F., Roveri, L., Filauri, P., Sacco, S., Orlandi, B., De Santis, F., Tiseo, C., Notturno, F., Ornello, R., Pavia, M., Squassina, G., Cobelli, M., Morassi, M., Magni, E., Invernizzi, P., Pepe, F., Bigni, B., Costa, P., Crabbio, M., Griffini, S., Palmerini, F., Piras, M. P., Gallesio, I., Barbero, S., Ferrandi, D., Dui, G., Fancello, M. C., Zedda, S., Ticca, A., Saddi, M. V., Deiana, G., Rossi, R., Carboni, N., Mela, A., Amistà, P., Russo, M., Iannucci, G., Pinna, V., Di Clemente, L., Santi, M., De Boni, A., De Luca, C., Natrella, M., Fanelli, G., Cristoferi, M., Bottacchi, E., Corso, G., Tosi, P., Sessa, M., Giossi, A., Baietti, Null, Romano, G., Meineri, P., Armentano, A., Versace, P., Arcudi, L., Galvano, G., Petralia, B., Feraco, P., Luppi, G., Giometto, B., Bignamini, V., Piffer, S., Meloni, G. B., Fabio, C., Maiore, M., Pintus, F., Pischedda, A., Manca, A., Mongili, C., Zanda, B., Baule, A., Florio, F., Ciccarese, G., Leone, M., Di Viesti, P., Pappalardo, M. P., Craparo, G., Gallo, C., Monaco, S., Mannino, M., Muto, M., Guarnieri, Gl., Andreone, V., Passalacqua, G., Allegritti, M., Caproni, S., Filizzolo, M., Salmaggi, A., Giordano, A., Marini, C., Frattale, I., Lucente, G., Nozzoli, C., and Lupo, F. A.

Subjects
Stent, Acute stroke, Settore MED/37 - Neuroradiologia, Acute stroke Internal carotid artery diseases Stent Thrombectomy, Neurology (clinical), General Medicine, Settore MED/26, Internal carotid artery diseases, Thrombectomy
Abstract

The management of tandem extracranial internal carotid artery and intracranial large vessel occlusion during endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) has been under-investigated. We sought to investigate outcomes of AIS patients with tandem occlusion (TO) treated with carotid artery stenting (CAS) compared to those not treated with CAS (no-CAS) during EVT.We performed a cohort study using data from AIS patients enrolled in the Italian Registry of Endovascular Treatment in Acute Stroke. Outcomes were 3 months' mortality, functional outcome, complete and successful recanalization, any intracranial hemorrhage, parenchymal hematoma and symptomatic intracerebral hemorrhage.Among 466 AIS patients with TO, CAS patients were 122 and no-CAS patients were 226 (118 excluded). After adjustment for unbalanced variables, CAS was associated with a lower rate of 3 months' mortality (OR 0.407, 95% CI 0.171-0.969, p = 0.042). After adjustment for pre-defined variables, CAS was associated with a lower rate of 3 months' mortality (aOR 0.430, 95% CI 0.187-0.989, p = 0.047) and a higher rate of complete recanalization (aOR 1.986, 95% CI 1.121-3.518, p = 0.019), successful recanalization (aOR 2.433, 95% CI 1.263-4.686, p = 0.008) and parenchymal hematoma (aOR 2.876, 95% CI 1.173-7.050, p = 0.021). CAS was associated with lower 3 months mortality (OR 0.373, 95% CI 0.141-0.982, p = 0.046) and higher rates of successful recanalization (OR 2.082, 95% CI 1.099-3.942, p = 0.024) after adjustment for variables associated with 3 months' mortality and successful recanalization, respectively.Among AIS patients with TO, CAS during EVT was associated with a higher rate of successful reperfusion and a lower rate of 3 months' mortality.

Published
2022

13. Screening for Fabry disease in patients with ischaemic stroke at young age: the Italian Project on Stroke in Young Adults

Author

Poli, L., Zedde, M., Zini, A., Del Sette, M., Lodigiani, C., Spalloni, A., Di Lisi, F., Toriello, A., Piras, V., Stilo, C., Tomelleri, G., Tancredi, L., Paciaroni, M., Silvestrelli, G., Adami, A., Costa, P., Morotti, A., De Giuli, V., Caria, F., Gamba, M., Malferrari, G., Simone, A. M., Musolino, R., Giorli, E., Banfi, E., Marcheselli, S., Rasura, M., Pugliese, N., Melis, M., Bovi, P., Padovani, A., Burlina, A., Pezzini, A., Del Zotto, Elisabetta, Giossi, Alessia, Sessa, Maria, Gilberti, Nicola, Magoni, Mauro, Ferrazzi, Paola, Librè, Luca, Rota, Lidia Luciana, Patella, Rosalba, Di Liso, Filomena, Calabrò, Rocco Salvatore, Bramanti, Placido, La Spina, Paolo, Finocchi, Cinzia, Balestrino, Maurizio, Bruno, Chiara, Massucco, Davide, Gandolfo, Carlo, Traverso, Elisabetta, DeLodovici, Maria Luisa, Verrengia, Elena Pinuccia, Carimati, Federico, Bono, Giorgio, DellʼAcqua, Maria Luisa, Bigliardi, Guido, Vandelli, Laura, Nichelli, Paolo Frigio, Carletti, Monica, Cerrato, Paolo, Iacoviello, Licia, Di Castelnuovo, Augusto, de Gaetano, Giovanni, Grassi, Mario, Locatelli, Giampiero, Caso, Valeria, DʼAmore, Cataldo, Agnelli, Giancarlo, Checcarelli, Nicoletta, Guidotti, Mario, Arnaboldi, Marco, Giacalone, Giacomo, Zanoli, Elisa, Cavallini, Anna, Persico, Alessandra, Micieli, Giuseppe, Chiti, Alberto, Orlandi, Giovanni, Marchi, Piernicola, Lanari, Alessia, Ciccone, Alfonso, Cucurachi, Laura, Bonifati, Marco Domenico, and Marcello, Norina

Published
2017
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14. Subclinical Vascular Brain Lesions in Young Adults With Acute Ischemic Stroke

Author

De Giuli, Valeria, primary, Grassi, Mario, additional, Besana, Michele, additional, Zedde, Marialuisa, additional, Zini, Andrea, additional, Lodigiani, Corrado, additional, Marcheselli, Simona, additional, Cavallini, Anna, additional, Micieli, Giuseppe, additional, Rasura, Maurizia, additional, DeLodovici, Maria Luisa, additional, Tomelleri, Giampaolo, additional, Checcarelli, Nicoletta, additional, Chiti, Alberto, additional, Giorli, Elisa, additional, Del Sette, Massimo, additional, Tancredi, Lucia, additional, Toriello, Antonella, additional, Braga, Massimiliano, additional, Morotti, Andrea, additional, Pezzini, Debora, additional, Locatelli, Martina, additional, Mazzoleni, Valentina, additional, Bonacina, Sonia, additional, Gamba, Massimo, additional, Magoni, Mauro, additional, Patella, Rosalba, additional, Spalloni, Alessandra, additional, Maria Simone, Anna, additional, Pascarella, Rosario, additional, Beretta, Sandro, additional, Padovani, Alessandro, additional, Gasparotti, Roberto, additional, Pezzini, Alessandro, additional, Gilberti, Nicola, additional, Ferrazzi, Paola, additional, Banfi, Elena, additional, Librè, Luca, additional, Traverso, Elisabetta, additional, Schirinzi, Erika, additional, Carimati, Federico, additional, Cappellari, Manuel, additional, Locatelli, Giampiero, additional, Demelas, Laura, additional, Ferrario, Davide, additional, Persico, Alessandra, additional, Orlandi, Giovanni, additional, Napoli, Manuela, additional, Moratti, Claudio, additional, and Guidotti, Mario, additional

Published
2021
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16. A snapshot of emergency neurology management in the Lombardy Region, Italy.

Author

Zanferrari, Carla, Salmaggi, Andrea, on behalf of the Lombardy section of the Italian Association for Emergency Neurology (ANEU), Belcastro, Vincenzo, Domina, Elisabetta, Beretta, Sandro, Braga, Massimiliano, Bonato, Sara, Ghione, Isabella, Caputi, Luigi, Brusaferri, Fabio, Cavallini, Anna, Persico, Alessandra, Ciccone, Alfonso, Silvestrelli, Giorgio, Clerici, Raffaella, De Piazza, Claudio, Conti, Giancarlo, Cotelli, Maria Sofia, and Turla, Marinella

Abstract

Background: The assessment of human and diagnostic resources is a prerequisite to improving the management of emergency neurology.Objective: To provide a landscape on the organization of the Lombardy Region hospitals for emergency neurological care management.Methods: We designed an anonymized questionnaire including 6 sections with 21 questions on facilities, human and diagnostic resources, and intra- and between-hospital connections. The time needed to fill the questionnaire was estimated not to exceed 6 min.Results: The questionnaire was returned by 33/41 (80.5%) hospitals, 22 classified as level 1 (spoke), and 11 as level 2 (hub). Five of 33 (15%) did not have a neurology unit. The mean annual rate of neurological consultations accounted for 5-6% of all admissions (range 2-8%) and did not differ between levels 1 and 2 hospitals. Neurologists were 24-h available in 21/33 (64%) hospitals, 12-h and on call at night in 6 (18%), less than 12 h without nocturnal availability in 5 (15%), and neither present nor available in 1 (3%). Brain CT and CSF examinations were 24-h universally available, whereas EEG and neurosonology were not in most hospitals. Despite angio-CT was 24-h available in more than 75% of the hospitals, only 45% of them had 24-h availability of diffusion/perfusion imaging, and 43% were not available at any time. Only 12% of the hospitals had 24-h availability of neuroradiologists and 6% of interventional neuroradiologists.Conclusion: Our data, while emphasizing current critical issues, offer clues for identifying priorities and improving the management of emergency and time-dependent neurological diseases. [ABSTRACT FROM AUTHOR]

Published
2022
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19. European Multicenter Study of ET-COVID-19

Author

Cagnazzo, Federico, primary, Piotin, Michel, additional, Escalard, Simon, additional, Maier, Benjamin, additional, Ribo, Marc, additional, Requena, Manuel, additional, Pop, Raoul, additional, Hasiu, Anca, additional, Gasparotti, Roberto, additional, Mardighian, Dikran, additional, Piano, Mariangela, additional, Cervo, Amedeo, additional, Eker, Omer Faruk, additional, Durous, Vincent, additional, Sourour, Nader-Antoine, additional, Elhorany, Mahmoud, additional, Zini, Andrea, additional, Simonetti, Luigi, additional, Marcheselli, Simona, additional, Paolo, Nuzzi Nunzio, additional, Houdart, Emmanuel, additional, Guédon, Alexis, additional, Ligot, Noémie, additional, Mine, Benjamin, additional, Consoli, Arturo, additional, Lapergue, Bertrand, additional, Cordona Portela, Pere, additional, Urra, Xabier, additional, Rodriguez, Alejandro, additional, Bolognini, Federico, additional, Lebedinsky, Pablo Ariel, additional, Pasco-Papon, Anne, additional, Godard, Sophie, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Limbucci, Nicola, additional, Nencini, Patrizia, additional, Nappini, Sergio, additional, Saia, Valentina, additional, Caldiera, Valentina, additional, Romano, Daniele, additional, Frauenfelder, Giulia, additional, Gallesio, Ivan, additional, Gola, Giuliano, additional, Menozzi, Roberto, additional, Genovese, Antonio, additional, Terrana, Alberto, additional, Giorgianni, Andrea, additional, Cappellari, Manuel, additional, Augelli, Raffaele, additional, Invernizzi, Paolo, additional, Pavia, Marco, additional, Lafe, Elvis, additional, Cavallini, Anna, additional, Giossi, Alessia, additional, Besana, Michele, additional, Valvassori, Luca, additional, Macera, Antonio, additional, Castellan, Lucio, additional, Salsano, Giancarlo, additional, Di Caterino, Fortunato, additional, Biondi, Alessandra, additional, Arquizan, Caroline, additional, Lebreuche, Julien, additional, Galvano, Gianluca, additional, Cannella, Alfio, additional, Cosottini, Mirco, additional, Lazzarotti, Guido, additional, Guizzardi, Giuseppe, additional, Stecco, Alessandro, additional, Tassi, Rossana, additional, Bracco, Sandra, additional, Bianchini, Elena, additional, Micieli, Camilla, additional, Pascarella, Rosario, additional, Napoli, Manuela, additional, Causin, Francesco, additional, Desal, Hubert, additional, Cotton, François, additional, Costalat, Vincent, additional, Delvoye, François, additional, Ciccio, Gabriele, additional, Smajda, Stanislas, additional, Redjem, Hocine, additional, Hébert, Solène, additional, Blanc, Raphaël, additional, Mazighi, Mikael, additional, Desilles, Jean-Philippes, additional, Mihoc, Dan, additional, Manisor, Monica, additional, Beaujeux, Rémy, additional, Quenardelle, Véronique, additional, Gheoca, Roxana, additional, Wolff, Valérie, additional, Pero, Guiglielmo, additional, Giuditta, Giussani, additional, Chiara, Ceresa, additional, Riva, Roberto, additional, Cappucci, Matteo, additional, Laubacher, Morgane, additional, Tuttle, Celia, additional, Piergallini, Lorenzo, additional, Turjman, Francis, additional, Clarençon, Frédéric, additional, Shotar, Eimad, additional, Lenck, Stéphanie, additional, Premat, Kevin, additional, Degos, Vincent, additional, Samson, Yves, additional, Rosso, Charlotte, additional, Alamowitch, Sonia, additional, Cirillo, Luigi, additional, Gentile, Mauro, additional, Migliaccio, Ludovica, additional, Isceri, Salvatore, additional, Rossi, Simone, additional, Baldini, Tommaso, additional, Dall’Olio, Massimo, additional, Cellerini, Martino, additional, Saint-Maurice, Jean-Pierre, additional, Civelli, Vittorio, additional, Fantoni, Matteo, additional, Gilles, Naeije, additional, Lise, Jodaïtis, additional, Boris, Lubicz, additional, Elens, Stephanie, additional, Thomas, Bonnet, additional, Adrien, Guenego, additional, Niloufar, Sadeghi, additional, Marc, Van Nuffelen, additional, Maria, Federico Di, additional, Coskun, Oguzhan, additional, Rodesch, Georges, additional, Zimatore, Sergio, additional, Florent, Gariel, additional, Berge, Jérôme, additional, Menegon, Patrice, additional, Barreau, Xavier, additional, Tourdias, Thomas, additional, Olindo, Stéphane, additional, Lucas, Ludovic, additional, Liegey, Jean-Sebastien, additional, Sagnier, Sharmila, additional, Renou, Pauline, additional, Couture, Marie, additional, Debruxelles, Sabrina, additional, Poli, Mathilde, additional, Musacchio, Mariano, additional, Delaitre, Mariette, additional, Padolecchia, Riccardo, additional, Ganci, Giuseppe, additional, Sugo, Annalisa, additional, Stefano, Barbero, additional, Giovanni, Taverna Giacomo, additional, Scoditti, Umberto, additional, Castellini, Paola, additional, Latte, Lilia, additional, Grisendi, Ilaria, additional, Epifani, Enrico, additional, Vizzari, Francesco, additional, Molinaro, Stefano, additional, Nativo, Luca, additional, Vinacci, Gabriele, additional, Bonetti, Bruno, additional, Micheletti, Nicola, additional, Tomelleri, Giampaolo, additional, Zampieri, Piergiuseppe, additional, Plebani, Mauro, additional, Grazioli, Andrea, additional, Ricciardi, Giuseppe Kenneth, additional, Polistena, Alessandra, additional, Alessando, Sgreccia, additional, Sanfilippo, Giuseppina, additional, Persico, Alessandra, additional, Boadu, William, additional, Cuzzoni, Maria Giovanna, additional, Magno, Serena, additional, Toscano, Gianpaolo, additional, Denaro, Maria Federica, additional, Tosi, Piera, additional, Censori, Bruno, additional, Puglisi, Valentina, additional, Vinciguerra, Luisa, additional, De Giuli, Valeria, additional, Mavillo, Nicola, additional, Renieri, Leonardo, additional, Fainardi, Enrico, additional, Vitale, Giovanni, additional, Panagiotis, Primikiris, additional, Charbonnier, Guillaume, additional, Claudio, Moratti, additional, Sallustio, Fabrizio, additional, Wlderk, Andrea, additional, Russo, Riccardo, additional, Bergui, Mauro, additional, Comelli, Chiara, additional, Boghi, Andrea, additional, Moynier, Marinette, additional, Maria Ciceri, Elisa Francesca, additional, Toni, Danilo, additional, Frandon, Julien, additional, Mourand, Isabelle, additional, Gaillard, Nicolas, additional, Mangiafico, Salvatore, additional, Derraz, Imad, additional, Dargazanli, Cyril, additional, Lefevre, Pierre-Henri, additional, Riquelme, Carlos, additional, Gascou, Gregory, additional, and Bonafe, Alain, additional

Published
2021
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20. Vessel wall magnetic resonance imaging in COVID‐19‐associated cryptogenic ischemic stroke.

Author

Mazzacane, Federico, Zito, Antonio, Magno, Serena, Persico, Alessandra, Mazzoleni, Valentina, Asteggiano, Carlo, Rognone, Elisa, Pichiecchio, Anna, Padovani, Alessandro, Cavallini, Anna, and Morotti, Andrea

Subjects
ISCHEMIC stroke, MAGNETIC resonance imaging, STROKE, COVID-19, STROKE patients, DISEASE complications
Abstract

Background and purpose: Acute ischemic stroke (AIS) is a common complication of coronavirus disease 2019 (COVID‐19), but the underlying biological mechanisms remain unclear. We aimed to describe the prevalence of vessel wall alterations in patients with cryptogenic stroke through vessel wall magnetic resonance imaging (vwMRI). Methods: All consecutive patients admitted for AIS and COVID‐19 to a single neuro‐COVID unit from 10 November to 31 December 2020 were prospectively evaluated and underwent a complete etiologic workup for AIS. In patients with cryptogenic stroke, the diagnostic workup was completed with vwMRI study. Results: After the exclusion of four patients ineligible for MRI, a total of 10 patients were included (median age = 78 years, 50% males), of whom four (40%) had a cryptogenic stroke. vwMRI showed vascular changes consistent with inflammation of intracranial artery walls in three subjects (75%). Two patients had focal and one multifocal involvement. Conclusions: vwMRI detected signs of vascular inflammation in the majority of patients with cryptogenic AIS, leading to an etiologic definition with potential therapeutical implications. Our findings are best interpreted as hypothesis‐generating, suggesting the possibility of expanding the diagnostic workup of cryptogenic stroke with vessel wall imaging. [ABSTRACT FROM AUTHOR]

Published
2022
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23. IER-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Thrombectomy for Stroke

Author

Cappellari, Manuel, Mangiafico, Salvatore, Saia, Valentina, Pracucci, Giovanni, Nappini, Sergio, Nencini, Patrizia, Konda, Daniel, Sallustio, Fabrizio, Vallone, Stefano, Zini, Andrea, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Pitrone, Antonio, Grillo, Francesco, Saletti, Andrea, De Vito, Alessandro, Gasparotti, Roberto, Magoni, Mauro, Puglielli, Edoardo, Casalena, Alfonsina, Causin, Francesco, Baracchini, Claudio, Castellan, Lucio, Malfatto, Laura, Menozzi, Roberto, Scoditti, Umberto, Comelli, Chiara, Duc, Enrica, Comai, Alessio, Franchini, Enrica, Cosottini, Mirco, Mancuso, Michelangelo, Peschillo, Simone, De Michele, Manuela, Giorgianni, Andrea, Delodovici, Maria Luisa, Lafe, Elvis, Denaro, Maria Federica, Burdi, Nicola, Internò, Saverio, Cavasin, Nicola, Critelli, Adriana, Chiumarulo, Luigi, Petruzzellis, Marco, Doddi, Marco, Carolei, Antonio, Auteri, William, Petrone, Alfredo, Padolecchia, Riccardo, Tassinari, Tiziana, Pavia, Marco, Invernizzi, Paolo, Turcato, Gianni, Forlivesi, Stefano, Ciceri, Elisa Francesca Maria, Bonetti, Bruno, Inzitari, Domenico, Toni, Danilo, Limbucci, Nicola, Consoli, Arturo, Renieri, Leonardo, Fainardi, Enrico, Gandini, Roberto, Pampana, Enrico, Diomedi, Marina, Koch, Giacomo, Verganti, Luca, Sacchetti, Federico, Zelent, Gabriele, Bigliardi, Guido, Picchetto, Livio, Vandelli, Laura, Romano, Daniele Giuseppe, Cioni, Samuele, Gennari, Paola, Cerase, Alfonso, Martini, Giuseppe, Stura, Guido, Daniele, Dino, Naldi, Andrea, Papa, Rosario, Vinci, Sergio Lucio, Bernava, Gianmarco, Velo, Mariano, Caragliano, Antonio, Tessitore, Agostino, Buonomo, Orazio, Musolino, Rossella, La Spina, Paolino, Casella, Carmela, Carolina Fazio, Maria, Cotroneo, Masina, Onofrio, Marcello, Azzini, Cristiano, Casetta, Ilaria, Mardighian, Dikran, Frigerio, Michele, Costa, Angelo, Di Egidio, Vincenzo, Lattanzi, Ruggero, Assetta, Maurizio, Cester, Giacomo, Mavilio, Nicola, Serrati, Carlo, Piazza, Paolo, Epifani, Enrico, Andreone, Andrea, Castellini, Paola, Latte, Lilia, Grisendi, Ilaria, Vaudano, Giacomo, Comelli, Simone, Cavallo, Roberto, Chianale, Gigliola, Simonetti, Luigi, Taglialatela, Francesco, Isceri, Salvatore, Procaccianti, Gaetano, Zaniboni, Anna, Borghi, Annamaria, Bonatti, Giampietro, Ferro, Federica, Bonatti, Matteo, Dall’Ora, Elisa, Currò Dossi, Roberto, Turri, Emanuela, Turri, Mara, Puglioli, Michele, Lazzarotti, Guido, Lauretti, DARIO LUCA, Giannini, Nicola, Maccarone, Miriam, Orlandi, Giovanni, Chiti, Alberto, Guidetti, Giulio, Biraschi, Francesco, Falcou, Anne, Anzini, Alexia, Mancini, Alessandra, Fausti, Silvia, Di Mascio, Maria Teresa, Durastanti, Laura, Sbardella, Emilia, Mellina, Vittorio, Baruzzi, Fabio, Pellegrino, Carlo, Terrana, Alberto, Carimati, Federico, Ruggiero, Maria, Sanna, Antioco, Passarin, Maria Grazia, Colosimo, Cesare, Pedicelli, Alessandro, D’Argento, Francesco, Alexandre, Andrea, Frisullo, Giovanni, Zappoli, Federico, Martignoni, Alessandra, Cavallini, Anna, Persico, Alessandra, Valvassori, Luca, Piano, Mariangela, Agostoni, Elio, Motto, Cristina, Gatti, Antonella, Longoni, Marco, Guccione, Angelo, Tortorella, Rachele, Zampieri, Piergiuseppe, Zimatore, Domenico Sergio, Grazioli, Andrea, Ricciardi, Giuseppe Kenneth, Augelli, Raffaele, Bovi, Paolo, Tomelleri, Giampaolo, Micheletti, Nicola, Semeraro, Vittorio, Lucarelli, Nicola, Ganimede, Maria, Tinelli, Angelica, Pia Prontera, Maria, Pesare, Angela, Cagliari, Enrico, Quatrale, Rocco, Federico, Francesco, Passalacqua, Giovanni, Filauri, Pietro, Orlandi, Berardino, De Santis, Federica, Gabriele, Amleto, Tiseo, Cindy, Armentano, Antonio, Di Benedetto, Olindo, Silvagni, Umberto, Perrotta, Paolo, Crispino, Emanuela, Stancati, Furio, Rizzuto, Stefano, Pugliese, Pierfrancesco, Pisani, Ermanno, Siniscalchi, Antonio, Gaudiano, Carmen, Pirritano, Domenico, Del Giudice, Francesco, Calia, Stefano, Ganci, Giuseppe, Sugo, Annalisa, Scomazzoni, Francesco, Simionato, Franco, Roveri, Luisa, De Nicola, Maurizio, Giannoni, Mirko, Bruni, Stefano, Gambelli, Elena, Provinciali, Leandro, Carriero, Alessandro, Coppo, Lorenzo, Baldan, Julika, Paolo Nuzzi, Nunzio, Marcheselli, Simona, Corato, Manuel, Cotroneo, Enrico, Ricciardi, Fabrizio, Gigli, Renato, Pozzessere, Claudio, Pezzella, Francesca Romana, Corsi, Fabio, Squassina, Guido, Cobelli, Milena, Morassi, Mauro, Magni, Eugenio, Pepe, Fulvio, Bigni, Barbara, Costa, Paolo, Crabbio, Massimo, Griffini, Simona, Palmerini, Francesco, Piras, Maria Paola, Natrella, Massimiliano, Fanelli, Gianluca, Cristoferi, Massimo, Bottacchi, Edo, Corso, Giovanni, Tosi, Piera, Amistà, Pietro, Russo, Monia, Tettoni, Serena, Gallesio, Ivan, Mascolo, Maria Carmela, Meloni, Giovanni Battista, Fabio, Claudio, Maiore, Mario, Pintus, Francesco, Pischedda, Aldo, Manca, Antonio, Mongili, Claudia, Zanda, Bastianina, Sanna, Antonella, Baule, Antonio, Pappalardo, Maria Pia, Craparo, Giuseppe, Gallo, Cristina, Monaco, Serena, Mannino, Marina, Terruso, Valeria, Muto, Mario, Guarnieri, Gianluigi, Andreone, Vincenzo, Dui, Giovanni, Ticca, Anna, Salmaggi, Andrea, Iannucci, Giuseppe, Pinna, Vittore, Di Clemente, Loris, Perini, Francesco, De Boni, Antonella, De Luca, Cristina, De Giorgi, Franco, Corraine, Simona, Enne, Paolo, Ganau, Claudio, and Piras, Valeria

Subjects
Male, medicine.medical_specialty, Fibrinolytic Agents/therapeutic use Humans Male Middle Aged *Nomograms Postoperative Complications/etiology Risk Assessment Risk Factors Stroke/complications/drug therapy/*surgery Thrombectomy/*adverse effects Thrombolytic Therapy/adverse effects, medicine.medical_treatment, contraindications, Risk Assessment, NO, Brain Ischemia, Brain ischemia, Postoperative Complications, Fibrinolytic Agents, Risk Factors, contraindications ◼ logistic models ◼ nomograms ◼ standard of care ◼ thrombectomy, medicine, 80 and over, Humans, Thrombolytic Therapy, Stroke, contraindications, logistic models, nomograms, standard of care, thrombectomy, Aged, Cerebral Hemorrhage, Aged, 80 and over, Advanced and Specialized Nursing, Intracerebral hemorrhage, Receiver operating characteristic, business.industry, Thrombolysis, Nomogram, Middle Aged, medicine.disease, logistic models, nomograms, standard of care, thrombectomy, Female, Thrombectomy, Tissue Plasminogen Activator, Nomograms, Settore MED/26 - NEUROLOGIA, Neurology (clinical), Radiology, Cardiology and Cardiovascular Medicine, business, Fibrinolytic agent, Cohort study
Abstract

Background and Purpose— As a reliable scoring system to detect the risk of symptomatic intracerebral hemorrhage after thrombectomy for ischemic stroke is not yet available, we developed a nomogram for predicting symptomatic intracerebral hemorrhage in patients with large vessel occlusion in the anterior circulation who received bridging of thrombectomy with intravenous thrombolysis (training set), and to validate the model by using a cohort of patients treated with direct thrombectomy (test set). Methods— We conducted a cohort study on prospectively collected data from 3714 patients enrolled in the IER (Italian Registry of Endovascular Stroke Treatment in Acute Stroke). Symptomatic intracerebral hemorrhage was defined as any type of intracerebral hemorrhage with increase of ≥4 National Institutes of Health Stroke Scale score points from baseline ≤24 hours or death. Based on multivariate logistic models, the nomogram was generated. We assessed the discriminative performance by using the area under the receiver operating characteristic curve. Results— National Institutes of Health Stroke Scale score, onset-to-end procedure time, age, unsuccessful recanalization, and Careggi collateral score composed the IER-SICH nomogram. After removing Careggi collateral score from the first model, a second model including Alberta Stroke Program Early CT Score was developed. The area under the receiver operating characteristic curve of the IER-SICH nomogram was 0.778 in the training set (n=492) and 0.709 in the test set (n=399). The area under the receiver operating characteristic curve of the second model was 0.733 in the training set (n=988) and 0.685 in the test set (n=779). Conclusions— The IER-SICH nomogram is the first model developed and validated for predicting symptomatic intracerebral hemorrhage after thrombectomy. It may provide indications on early identification of patients for more or less postprocedural intensive management.

Published
2019

24. Validation and Comparison of Noncontrast CT Scores to Predict Intracerebral Hemorrhage Expansion

Author

Poli, Loris, primary, Leuci, Eleonora, additional, Costa, Paolo, additional, De Giuli, Valeria, additional, Caria, Filomena, additional, Candeloro, Elisa, additional, Persico, Alessandra, additional, Gamba, Massimo, additional, Magoni, Mauro, additional, Micieli, Giuseppe, additional, Cavallini, Anna, additional, Padovani, Alessandro, additional, Pezzini, Alessandro, additional, and Morotti, Andrea, additional

Published
2019
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25. Longitudinal Study on Low-Dose Aspirin versus Placebo Administration in Silent Brain Infarcts: The Silence Study

Author

Maestrini, Ilaria, primary, Altieri, Marta, additional, Di Clemente, Laura, additional, Vicenzini, Edoardo, additional, Pantano, Patrizia, additional, Raz, Eytan, additional, Silvestrini, Mauro, additional, Provinciali, Leandro, additional, Paolino, Isabella, additional, Marini, Carmine, additional, Di Giuseppe, Matteo, additional, Russo, Tommasina, additional, Federico, Francesco, additional, Coppola, Cristiana, additional, Prontera, Maria Pia, additional, Mezzapesa, Domenico Maria, additional, Lucivero, Vincenzo, additional, Parnetti, Lucilla, additional, Sarchielli, Paola, additional, Peducci, Maria, additional, Inzitari, Domenico, additional, Carlucci, Giovanna, additional, Serrati, Carlo, additional, Zat, Carla, additional, Cavallini, Anna, additional, Persico, Alessandra, additional, Micieli, Giuseppe, additional, Bastianello, Stefano, additional, and Di Piero, Vittorio, additional

Published
2018
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26. An Automated Voice Response System for Anticoagulant Therapy Management

Author

Quaglini, Silvana, Giorgino, Toni, Rojas Barahona, Lina Maria, Caffi, Ezio, Devito, Mauro, Persico, Alessandra, Cavallini, Anna, Laboratory for BioMedical Informatics (BMI), Università degli Studi di Pavia = University of Pavia (UNIPV), Natural Language Processing: representation, inference and semantics (TALARIS), Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Fondazione 'Istituto Neurologico Nazionale C. Mondino', University of Pavia, and Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Lorraine (INPL)-Université Nancy 2-Université Henri Poincaré - Nancy 1 (UHP)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Lorraine (INPL)-Université Nancy 2-Université Henri Poincaré - Nancy 1 (UHP)

Subjects
Human-Computer Interaction, Medical informatics, [INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL], ACM: I.: Computing Methodologies/I.2: ARTIFICIAL INTELLIGENCE/I.2.7: Natural Language Processing
Abstract

International audience; The system described in this paper is aimed at improving the clinical workflow of post-stroke patients under oral anticoagulant therapy (OAT). The system helps both physicians and patients during the periodic control visits necessary to assess the anticoagulation status and the next therapeutic plan. Controls represent a burden for both patients, which after blood drawing must wait for the result, and for physicians, that, after assessing the therapy plan, must communicate it to patients, face-to-face or by telephone. A system is proposed, which embeds an algorithm for the patient-tailored calculation of the drug dosage and scheduling, and an automatic telephone dialogue for the communication of the therapy plan, once it has been validated or adjusted by the physician.

Published
2009

27. Clinical correlations of CSF single IgG bands

Author

Franciotta, Diego, Bergamaschi, Roberto, Amato, Maria Pia, Zardini, Elisabetta, Persico, Alessandra, Portaccio, Emilio, and Lolli, Francesco

Subjects
Nervous system diseases -- Causes of, Nervous system diseases -- Diagnosis, Nervous system diseases -- Care and treatment, Nervous system diseases -- Reports, Health
Published
2005

28. Letter to the Editor

Author

Franciotta, Diego, primary, Bestetti, Arabella, additional, Bergamaschi, Roberto, additional, Piccolo, Giovanni, additional, Persico, Alessandra, additional, and Cinque, Paola, additional

Published
2006
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29. An Automated Voice Response System for Anticoagulant Therapy Management.

Author

Adlassnig, Klaus-Peter, Blobel, Bernd, Mantas, John, Masic, Izet, Quaglini, Silvana, Giorgino, Toni, Rojas-Barahona, Lina M., Caffi, Ezio, De Vito, Mauro, Persico, Alessandra, and Cavallini, Anna

Abstract

The system described in this paper is aimed at improving the clinical workflow of post-stroke patients under oral anticoagulant therapy (OAT). The system helps both physicians and patients during the periodic control visits necessary to assess the anticoagulation status and the next therapeutic plan. Controls represent a burden for both patients, which after blood drawing must wait for the result, and for physicians, that, after assessing the therapy plan, must communicate it to patients, face-to-face or by telephone. A system is proposed, which embeds an algorithm for the patient-tailored calculation of the drug dosage and scheduling, and an automatic telephone dialogue for the communication of the therapy plan, once it has been validated or adjusted by the physician. [ABSTRACT FROM AUTHOR]

Published
2009

31. An automated voice response system for anticoagulant therapy management.

Author

Quaglini S, Giorgino T, Rojas-Barahona LM, Caffi E, De Vito M, Persico A, and Cavallini A

Subjects
Decision Support Systems, Clinical, Home Care Services, Humans, Stroke drug therapy, Anticoagulants therapeutic use, Speech Recognition Software
Abstract

The system described in this paper is aimed at improving the clinical workflow of post-stroke patients under oral anticoagulant therapy (OAT). The system helps both physicians and patients during the periodic control visits necessary to assess the anticoagulation status and the next therapeutic plan. Controls represent a burden for both patients, which after blood drawing must wait for the result, and for physicians, that, after assessing the therapy plan, must communicate it to patients, face-to-face or by telephone. A system is proposed, which embeds an algorithm for the patient-tailored calculation of the drug dosage and scheduling, and an automatic telephone dialogue for the communication of the therapy plan, once it has been validated or adjusted by the physician.

Published
2009

32. Transient global amnesia: hippocampal magnetic resonance imaging abnormalities.

Author

Alberici E, Pichiecchio A, Caverzasi E, Farina LM, Persico A, Cavallini A, and Bastianello S

Subjects
Aged, Brain Mapping, Female, Humans, Male, Middle Aged, Retrospective Studies, Amnesia, Transient Global diagnosis, Diffusion Magnetic Resonance Imaging methods, Hippocampus pathology
Abstract

Transient global amnesia (TGA) is an episodic dysfunction of declarative memory that usually resolves within 12 hours and whose underlying pathophysiological mechanisms are still unclear. Recent studies, on the basis of transient focal high-signal abnormalities in the hippocampus on diffusion-weighted imaging (DWI), suggest involvement of memory circuits in the temporo-mesial region. Out of a total of 65 patients presenting with acute or subacute TGA between May 2004 and May 2008, we retrospectively analysed 21 in whom a DWI sequence was performed. Five patients showed a focal hippocampal signal alteration both on DWI and on conventional T2; this alteration was no longer detectable on follow-up MRI two months later. The presence of transient DWI and T2 alterations in the hippocampal formation suggests that TGA could have a multifactorial, non-vascular aetiology. The presence of local susceptibility to neuronal metabolic stress emerges as a likely hypothesis.

Published
2008

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