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15 results on '"Persad, Aaron H."'

2. Hardness Tester for Analog Planetary Rocks: A Preliminary Assessment in Microgravity Flight

Author

Pires, Ana, Costa, Catarina, Moura, Rui, Persad, Aaron H., Reimuller, Jason, Gowanlock, Derek, Alavi, Shahrukh, Beatty, Heather Wright, Almeida, José, Almeida, Fernando, Silva, Eduardo, Pérez-Alberti, Augusto, Chaminé, Helder I., Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Chaminé, Helder I., editor, and Fernandes, José Augusto, editor

Published
2023
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4. Hardness Tester for Analog Planetary Rocks: A Preliminary Assessment in Microgravity Flight

Author

Pires, Ana, primary, Costa, Catarina, additional, Moura, Rui, additional, Persad, Aaron H., additional, Reimuller, Jason, additional, Gowanlock, Derek, additional, Alavi, Shahrukh, additional, Beatty, Heather Wright, additional, Almeida, José, additional, Almeida, Fernando, additional, Silva, Eduardo, additional, Pérez-Alberti, Augusto, additional, and Chaminé, Helder I., additional

Published
2023
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6. Effect of Membrane Permeance and System Parameters on the Removal of Protein-Bound Uremic Toxins in Hemodialysis

Author

Massachusetts Institute of Technology. Department of Chemical Engineering, Massachusetts Institute of Technology. Department of Mechanical Engineering, Chow, Chun M., Persad, Aaron H., Karnik, Rohit, Massachusetts Institute of Technology. Department of Chemical Engineering, Massachusetts Institute of Technology. Department of Mechanical Engineering, Chow, Chun M., Persad, Aaron H., and Karnik, Rohit

Abstract

Inadequate clearance of protein-bound uremic toxins (PBUTs) during dialysis is associated with morbidities in chronic kidney disease patients. The development of high-permeance membranes made from materials such as graphene raises the question whether they could enable the design of dialyzers with improved PBUT clearance. Here, we develop device-level and multi-compartment (body) system-level models that account for PBUT-albumin binding (specifically indoxyl sulfate and p-cresyl sulfate) and diffusive and convective transport of toxins to investigate how the overall membrane permeance (or area) and system parameters including flow rates and ultrafiltration affect PBUT clearance in hemodialysis. Our simulation results indicate that, in contrast to urea clearance, PBUT clearance in current dialyzers is mass-transfer limited: Assuming that the membrane resistance is dominant, raising PBUT permeance from 3 × 10−6 to 10−5 m s−1 (or equivalently, 3.3 × increase in membrane area from ~ 2 to ~ 6 m2) increases PBUT removal by 48% (from 22 to 33%, i.e., ~ 0.15 to ~ 0.22 g per session), whereas increasing dialysate flow rates or adding adsorptive species have no substantial impact on PBUT removal unless permeance is above ~ 10−5 m s−1. Our results guide the future development of membranes, dialyzers, and operational parameters that could enhance PBUT clearance and improve patient outcomes.

Published
2023

8. List of Contributors

Author

Bonn, Daniel, primary, Bormashenko, Edward, additional, Bou Zeid, Wassim, additional, Brutin, David, additional, Carle, Florian, additional, Carrier, Odile, additional, Cavalli, Andrea, additional, Colinet, Pierre, additional, Colombani, Jean, additional, Di Marco, Paolo, additional, Dorbolo, Stéphane, additional, Duan, Fei, additional, Fairhurst, David, additional, Gambaryan-Roisman, Tatiana, additional, Laux, Didier, additional, Lopes, Marcus Camarinha, additional, Mailleur, Alexandra, additional, Maquet, Laurent, additional, Medale, Marc, additional, Moreau, Florian, additional, Mugele, Frieder, additional, Pauchard, Ludovic, additional, Persad, Aaron H., additional, Pirat, Christophe, additional, Rednikov, Alexey, additional, Rigollet, Fabrice, additional, Rubio, Ramon G., additional, Semenov, Sergey, additional, Sobac, Benjamin, additional, Starov, Victor, additional, Vancauwenberghe, Valérie, additional, Venzmer, Joachim, additional, Ward, Charles A., additional, Wei, Tao, additional, and Zhu, Guiping, additional

Published
2015
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14. ENGINEERS TEACHING ENGINEERING COMMUNICATION: INTEGRATING DISCIPLINARY EXPERTISE INTO THE ENGINEERING COMMUNICATION CURRICULUM

Author

Denbeigh, Kathleen, primary, Esensoy, Ali Vahit, additional, Kinnear, Penny, additional, Li, Jason, additional, Ma, Wilson, additional, MacArthur, Michelle, additional, Maloul, Asmaa, additional, Milicevic, Mario, additional, Persad, Aaron H., additional, Sasangohar, Farzan, additional, Tihanyi, Deborah, additional, and Yuan, Liang Leon, additional

Published
2012
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15. Condensation in One-Dimensional Dead-End Nanochannels

Author

Zhong, Junjie, Zandavi, Seyed Hadi, Li, Huawei, Bao, Bo, Persad, Aaron H., Mostowfi, Farshid, and Sinton, David

Abstract

Phase change at the nanoscale is at the heart of many biological and geological phenomena. The recent emergence and global implications of unconventional oil and gas production from nanoporous shale further necessitate a higher understanding of phase behavior at these scales. Here, we directly observe condensation and condensate growth of a light hydrocarbon (propane) in discrete sub-100 nm (∼70 nm) channels. Two different condensation mechanisms at this nanoscale are distinguished, continuous growth and discontinuous growth due to liquid bridging ahead of the meniscus, both leading to similar net growth rates. The growth rates agree well with those predicted by a suitably defined thermofluid resistance model. In contrast to phase change at larger scales (∼220 and ∼1000 nm cases), the rate of liquid condensate growth in channels of sub-100 nm size is found to be limited mainly by vapor flow resistance (∼70% of the total resistance here), with interface resistance making up the difference. The condensation-induced vapor flow is in the transitional flow regime (Knudsen flow accounting for up to 13% of total resistance here). Collectively, these results demonstrate that with confinement at sub-100 nm scales, such as is commonly found in porous shale and other applications, condensation conditions deviate from the microscale and larger bulk conditions chiefly due to vapor flow and interface resistances.

Published
2017
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