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1. Risk factors for placenta accreta spectrum disorders in women with any prior cesarean and a placenta previa or low lying: a prospective population-based study

Author

Kayem, Gilles, Seco, Aurélien, Vendittelli, Francoise, Crenn Hebert, Catherine, Dupont, Corinne, Branger, Bernard, Huissoud, Cyril, Fresson, Jeanne, Winer, Norbert, Langer, Bruno, Rozenberg, Patrick, Morel, Olivier, Bonnet, Marie Pierre, Perrotin, Franck, Azria, Elie, Carbillon, Lionel, Chiesa, Coralie, Raynal, Pierre, Rudigoz, René Charles, Patrier, Sophie, Beucher, Gaël, Dreyfus, Michel, Sentilhes, Loïc, and Deneux-Tharaux, Catherine

Published
2024
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2. Posttraumatic stress disorder 2 months after cesarean delivery: a multicenter prospective study

Author

Sentilhes, Loïc, Senat, Marie V., Le Lous, Maëla, Winer, Norbert, Rozenberg, Patrick, Kayem, Gilles, Verspyck, Eric, Fuchs, Florent, Azria, Elie, Gallot, Denis, Korb, Diane, Desbrière, Raoul, Le Ray, Camille, Chauleur, Céline, de Marcillac, Fanny, Perrotin, Franck, Parant, Olivier, Salomon, Laurent J., Gauchotte, Emilie, Bretelle, Florence, Sananès, Nicolas, Bohec, Caroline, Mottet, Nicolas, Legendre, Guillaume, Letouzey, Vincent, Haddad, Bassam, Vardon, Delphine, Madar, Hugo, Mattuizzi, Aurélien, Froeliger, Alizée, Daniel, Valérie, Regueme, Sophie, Roussillon, Caroline, Bénard, Antoine, Georget, Aurore, Darsonval, Astrid, Deneux-Tharaux, Catherine, and Loussert, Lola

Published
2024
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3. Tranexamic acid for reduction of blood loss after Caesarean delivery: a cost-effectiveness analysis of the TRAAP2 trial

Author

Senat, Marie-Victoire, Le Lous, Maëla, Winer, Norbert, Rozenberg, Patrick, Kayem, Gilles, Verspyck, Eric, Fuchs, Florent, Azria, Elie, Gallot, Denis, Korb, Diane, Desbrière, Raoul, Le Ray, Camille, Chauleur, Céline, de Marcillac, Fanny, Perrotin, Franck, Parant, Olivier, Salomon, Laurent J., Gauchotte, Emilie, Bretelle, Florence, Sananès, Nicolas, Bohec, Caroline, Mottet, Nicolas, Legendre, Guillaume, Letouzey, Vincent, Haddad, Bassam, Vardon, Delphine, Madar, Hugo, Froeliger, Alizée, Daniel, Valérie, Pharm.D, Regueme, Sophie, Roussillon, Caroline, Darsonval, Astrid, Sentilhes, Loïc, Bénard, Antoine, Petit, Solène, and Deneux-Tharaux, Catherine

Published
2023
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4. Balloon catheters versus vaginal prostaglandins for labour induction (CPI Collaborative): an individual participant data meta-analysis of randomised controlled trials

Author

Jones, Madeleine N, Palmer, Kirsten R, Pathirana, Maleesa M, Cecatti, Jose Guilherme, Filho, Olimpio B Moraes, Marions, Lena, Edlund, Måns, Prager, Martina, Pennell, Craig, Dickinson, Jan E, Sass, Nelson, Jozwiak, Marta, Eikelder, Mieke Ten, Rengerink, Katrien Oude, Bloemenkamp, Kitty W M, Henry, Amanda, Løkkegaard, Ellen C L, Christensen, Ib Jarle, Szychowski, Jeff M, Edwards, Rodney K, Beckmann, Michael, Diguisto, Caroline, Gouge, Amélie Le, Perrotin, Franck, Symonds, Ian, O’Leary, Sean, Rolnik, Daniel L, Mol, Ben W, and Li, Wentao

Published
2022
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5. Neonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial

Author

Boize, Philippe, Garabédian, Charles, Flamein, Florence, Le Lous, Maela, Beuchée, Alain, Gondry, Jean, Tourneux, Pierre, Coste-Mazeau, Perrine, Bedu, Antoine, Gallot, Denis, Coste, Karen, Chauleur, Céline, Patural, Hugues, Kayem, Gilles, Mitanchez, Delphine, Heckenroth, Hélène, Boubred, Farid, Sibiude, Jeanne, Desfrère, Luc, Bohec, Caroline, Mansir, Thierry, Koch, Antoine, Kuhn, Pierre, Tillouche, Nadia, Lapeyre, Fabrice, Perrotin, Franck, Favrais, Géraldine, Lecarpentier, Edouard, Durrmeyer, Xaxier, Equy, Véronique, Debillon, Thierry, Rigonnot, Luc, Lefoulgoc, Stéphanie, Brie, Claudia, Pagès, Anne-Sophie, Rayssiguier, Romy, Cambonie, Gilles, Cudeville, Corinne, Madeleneau, Doriane, Morel, Olivier, Hascoet, Jean-Michel, Letouzey, Vincent, Di Maio, Massimo, Salomon, Laurent J., Lapillonne, Alexandre, Schmitz, Thomas, Doret-Dion, Muriel, Sentilhes, Loic, Parant, Olivier, Claris, Olivier, Renesme, Laurent, Abbal, Julie, Girault, Aude, Torchin, Héloïse, Houllier, Marie, Le Saché, Nolwenn, Vivanti, Alexandre J, De Luca, Daniele, Winer, Norbert, Flamant, Cyril, Thuillier, Claire, Boileau, Pascal, Blanc, Julie, Brevaut, Véronique, Bouet, Pierre-Emmanuel, Gascoin, Géraldine, Beucher, Gaël, Datin-Dorriere, Valérie, Bounan, Stéphane, Bolot, Pascal, Poncelet, Christophe, Alberti, Corinne, Ursino, Moreno, Aupiais, Camille, and Baud, Olivier

Published
2022
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6. What is the impact of blood pressure on neurological symptoms and the risk of ESKD in primary and secondary thrombotic microangiopathies based on clinical presentation: a retrospective study

Author

Halimi, Jean-Michel, Thoreau, Benjamin, von Tokarski, Florent, Bauvois, Adeline, Gueguen, Juliette, Goin, Nicolas, Barbet, Christelle, Cloarec, Sylvie, Mérieau, Elodie, Lachot, Sébastien, Garot, Denis, Lemaignen, Adrien, Gyan, Emmanuel, Perrotin, Franck, Pouplard, Claire, Maillot, François, Gatault, Philippe, Sautenet, Bénédicte, Rusch, Emmanuel, Frémeaux-Bacchi, Véronique, Vigneau, Cécile, Bayer, Guillaume, and Fakhouri, Fadi

Published
2022
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7. Closed- or open-glottis pushing for vaginal delivery: a planned secondary analysis of the TRAnexamic Acid for Preventing postpartum hemorrhage after vaginal delivery study

Author

Sentilhes, Loïc, Winer, Norbert, Azria, Elie, Sénat, Marie Victoire, Le Ray, Camille, Vardon, Delphine, Perrotin, Franck, Desbrière, Raoul, Fuchs, Florent, Kayem, Gilles, Ducarme, Guillaume, Doret-Dion, Muriel, Huissoud, Cyril, Bohec, Caroline, Deruelle, Philippe, Darsonval, Astrid, Chrétien, Jean-Marie, Seco, Aurélien, Daniel, Valérie, Deneux-Tharaux, Catherine, Froeliger, Alizée, Madar, Hugo, and Bouchghoul, Hanane

Published
2024
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9. Posttraumatic stress disorder 2 months after cesarean delivery: a multicenter prospective study

Author

Froeliger, Alizée, primary, Deneux-Tharaux, Catherine, additional, Loussert, Lola, additional, Madar, Hugo, additional, Sentilhes, Loïc, additional, Senat, Marie V., additional, Le Lous, Maëla, additional, Winer, Norbert, additional, Rozenberg, Patrick, additional, Kayem, Gilles, additional, Verspyck, Eric, additional, Fuchs, Florent, additional, Azria, Elie, additional, Gallot, Denis, additional, Korb, Diane, additional, Desbrière, Raoul, additional, Le Ray, Camille, additional, Chauleur, Céline, additional, de Marcillac, Fanny, additional, Perrotin, Franck, additional, Parant, Olivier, additional, Salomon, Laurent J., additional, Gauchotte, Emilie, additional, Bretelle, Florence, additional, Sananès, Nicolas, additional, Bohec, Caroline, additional, Mottet, Nicolas, additional, Legendre, Guillaume, additional, Letouzey, Vincent, additional, Haddad, Bassam, additional, Vardon, Delphine, additional, Mattuizzi, Aurélien, additional, Froeliger, Alizée, additional, Daniel, Valérie, additional, Regueme, Sophie, additional, Roussillon, Caroline, additional, Bénard, Antoine, additional, Georget, Aurore, additional, and Darsonval, Astrid, additional

Published
2024
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10. 78 Foley catheter+oral misoprostol versus misoprostol for cervical ripening in nulliparous-obese women: a French multicenter RCT

Author

Guerby, Paul, primary, Berveiller, Paul, additional, Garabedian, Charles, additional, SENTILHES, Loïc, additional, Perrotin, Franck, additional, Winer, Norbert, additional, Vivanti, Alexandre, additional, Chauleur, Céline, additional, Boukerrou, Malik, additional, Fuchs, Florent, additional, Abossolo, Thierry, additional, Gallot, Denis, additional, Senat, Marie Victoire, additional, Desbriere, Raoul, additional, Letouzey, Vincent, additional, Azria, Elie, additional, Pierre, Fabrice, additional, Olivier-Abbal, Pascale, additional, Cassan, Perrine, additional, Arnaud, Catherine, additional, Devlamynck, Laure, additional, and Vayssiere, Christophe, additional

Published
2024
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11. Efficacy of early intrauterine balloon tamponade for immediate postpartum hemorrhage after vaginal delivery: a randomized clinical trial

Author

Rozenberg, Patrick, Sentilhes, Loïc, Goffinet, François, Vayssiere, Christophe, Senat, Marie-Victoire, Haddad, Bassam, Morel, Olivier, Garabedian, Charles, Vivanti, Alexandre, Perrotin, Franck, Kayem, Gilles, Azria, Elie, Raynal, Pierre, Verspyck, Eric, Sananes, Nicolas, Gallot, Denis, Bretelle, Florence, Seco, Aurélien, Winer, Norbert, and Deneux-Tharaux, Catherine

Published
2023
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12. Amniotic fluid peptides predict postnatal kidney survival in developmental kidney disease

Author

Allegaert, Karel, Aubard, Yves, Basmaison, Odile, Benevent, Jean-Baptiste, Biquard, Florence, Champion, Gérard, Delbosc, Jean-Marie, Eckart, Philippe, Froute, Marie-Françoise, Gaucherand, Pascal, Groussolles, Marion, Guigonis, Vincent, Hougas, Blandine, Le Bouar, Gwenaelle, Martin, Alain, Martin, Sophie, Maupin-Hyvonnet, Mariannick, Merveille, Marina, Mousty, Eve, Nobili, François, Ryckewaert, Amelie, Sartor, Agnes, Taque, Sophie, Winer, Norbert, Klein, Julie, Buffin-Meyer, Bénédicte, Boizard, Franck, Moussaoui, Nabila, Lescat, Ophélie, Breuil, Benjamin, Fedou, Camille, Feuillet, Guylène, Casemayou, Audrey, Neau, Eric, Hindryckx, An, Decatte, Luc, Levtchenko, Elena, Raaijmakers, Anke, Vayssière, Christophe, Goua, Valérie, Lucas, Charlotte, Perrotin, Franck, Cloarec, Sylvie, Benachi, Alexandra, Manca-Pellissier, Marie-Christine, Delmas, Hélène Laurichesse, Bessenay, Lucie, Le Vaillant, Claudine, Allain-Launay, Emma, Gondry, Jean, Boudailliez, Bernard, Simon, Elisabeth, Prieur, Fabienne, Lavocat, Marie-Pierre, Saliou, Anne-Hélène, De Parscau, Loic, Bidat, Laurent, Noel, Catherine, Floch, Corinne, Bourdat-Michel, Guylène, Favre, Romain, Weingertner, Anne-Sophie, Oury, Jean-François, Baudouin, Véronique, Bory, Jean-Paul, Pietrement, Christine, Fiorenza, Maryse, Massardier, Jérôme, Kessler, Sylvie, Lounis, Nadia, Auriol, Françoise Conte, Marcorelles, Pascale, Collardeau-Frachon, Sophie, Zürbig, Petra, Mischak, Harald, Magalhães, Pedro, Batut, Julie, Blader, Patrick, Saulnier Blache, Jean-Sebastien, Bascands, Jean-Loup, Schaefer, Franz, Decramer, Stéphane, and Schanstra, Joost P.

Published
2021
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14. A snapshot of the Covid-19 pandemic among pregnant women in France

Author

Kayem, Gilles, Lecarpentier, Edouard, Deruelle, Philippe, Bretelle, Florence, Azria, Elie, Blanc, Julie, Bohec, Caroline, Bornes, Marie, Ceccaldi, Pierre-François, Chalet, Yasmine, Chauleur, Céline, Cordier, Anne-Gael, Desbrière, Raoul, Doret, Muriel, Dreyfus, Michel, Driessen, Marine, Fermaut, Marion, Gallot, Denis, Garabédian, Charles, Huissoud, Cyril, Luton, Dominique, Morel, Olivier, Perrotin, Franck, Picone, Olivier, Rozenberg, Patrick, Sentilhes, Loïc, Sroussi, Jeremy, Vayssière, Christophe, Verspyck, Eric, Vivanti, Alexandre J., Winer, Norbert, Alessandrini, Vivien, and Schmitz, Thomas

Published
2020
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15. Tranexamic acid for the prevention of blood loss after cesarean among women with twins: a secondary analysis of the TRAnexamic Acid for Preventing Postpartum Hemorrhage Following a Cesarean Delivery randomized clinical trial

Author

Sentilhes, Loïc, Madar, Hugo, Le Lous, Maëla, Sénat, Marie Victoire, Winer, Norbert, Rozenberg, Patrick, Kayem, Gilles, Verspyck, Eric, Fuchs, Florent, Azria, Elie, Gallot, Denis, Korb, Diane, Desbrière, Raoul, Le Ray, Camille, Chauleur, Céline, de Marcillac, Fanny, Perrotin, Franck, Parant, Olivier, Salomon, Laurent J., Gauchotte, Emilie, Bretelle, Florence, Sananès, Nicolas, Bohec, Caroline, Mottet, Nicolas, Legendre, Guillaume, Letouzey, Vincent, Haddad, Bassam, Vardon, Delphine, Mattuizzi, Aurélien, Froeliger, Alizée, Bouchghoul, Hanane, Daniel, Valérie, Regueme, Sophie, Roussillon, Caroline, Georget, Aurore, Darsonval, Astrid, Benard, Antoine, and Deneux-Tharaux, Catherine

Published
2022
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17. Closed- or open-glottis pushing for vaginal delivery: a planned secondary analysis of the TRAnexamic Acid for Preventing postpartum hemorrhage after vaginal delivery study

Author

Froeliger, Alizée, primary, Deneux-Tharaux, Catherine, additional, Madar, Hugo, additional, Bouchghoul, Hanane, additional, Le Ray, Camille, additional, Sentilhes, Loïc, additional, Winer, Norbert, additional, Azria, Elie, additional, Sénat, Marie Victoire, additional, Vardon, Delphine, additional, Perrotin, Franck, additional, Desbrière, Raoul, additional, Fuchs, Florent, additional, Kayem, Gilles, additional, Ducarme, Guillaume, additional, Doret-Dion, Muriel, additional, Huissoud, Cyril, additional, Bohec, Caroline, additional, Deruelle, Philippe, additional, Darsonval, Astrid, additional, Chrétien, Jean-Marie, additional, Seco, Aurélien, additional, and Daniel, Valérie, additional

Published
2023
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18. Arabin pessary to prevent adverse perinatal outcomes in twin pregnancies with a short cervix: a multicenter randomized controlled trial (PESSARONE)

Author

Groussolles, Marion, Winer, Norbert, Sentilhes, Loïc, Biquart, Florence, Massoud, Mona, Vivanti, Alexandre J., Bouchghoul, Hanane, Rozenberg, Patrick, Olivier, Pascale, Desbriere, Raoul, Chauleur, Celine, Perrotin, Franck, Coatleven, Frederic, Fuchs, Florent, Bretelle, Florence, Tsatsaris, Vassilis, Salomon, Laurent J., Sananes, Nicolas, Kayem, Gilles, Houflin-Debarge, Veronique, Schmitz, Thomas, Benoist, Guillaume, Arnaud, Catherine, Ehlinger, Virginie, and Vayssière, Christophe

Published
2022
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19. Rationale and design of ePPOP-ID: a multicenter randomized controlled trial using an electronic-personalized program for obesity in pregnancy to improve delivery

Author

Deruelle, Philippe, Lelorain, Sophie, Deghilage, Sylvie, Couturier, Emmanuelle, Guilbert, Elodie, Berveiller, Paul, Sénat, Marie Victoire, Vayssière, Christophe, Sentilhes, Loïc, Perrotin, Franck, Gallot, Denis, Chauleur, Céline, Sananes, Nicolas, Roth, Emmanuel, Luton, Dominique, Caputo, Marie, Lorio, Elodie, Chatelet, Carla, Couster, Julien, Timbely, Oumar, Doret-Dion, Muriel, Duhamel, Alain, and Pigeyre, Marie

Published
2020
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21. Balloon Catheters Versus Vaginal Prostaglandins for Labour Induction (CPI Collaborative): An Individual Participant Data Meta-analysis of Randomised Controlled Trials

Author

Jones, Madeleine N., primary, Palmer, Kirsten R., additional, Pathirana, Maleesa M., additional, Cecatti, Jose Guilherme, additional, Moraes Filho, Olimpio B., additional, Marions, Lena, additional, Edlund, Måns, additional, Prager, Martina, additional, Pennell, Craig, additional, Dickinson, Jan E., additional, Sass, Nelson, additional, Jozwiak, Marta, additional, Ten Eikelder, Mieke, additional, Rengerink, Katrien Oude, additional, Bloemenkamp, Kitty W. M., additional, Henry, Amanda, additional, Løkkegaard, Ellen C. L., additional, Christensen, Ib Jarle, additional, Szychowski, Jeff M., additional, Edwards, Rodney K., additional, Beckmann, Michael, additional, Diguisto, Caroline, additional, Le Gouge, Amélie, additional, Perrotin, Franck, additional, Symonds, Ian, additional, O'Leary, Sean, additional, Rolnik, Daniel L., additional, Mol, Ben W., additional, and Li, Wentao, additional

Published
2023
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22. Oxytocin versus prostaglandins for labour Induction of women with an unfavourable cervix after 24 hours of cervical ripening (OPIC): protocol for an open multicentre randomised non-inferiority trial

Author

De Berti, Marion, primary, Le Gouge, Amélie, additional, Monmousseau, Fanny, additional, Gallot, Denis, additional, Sentilhes, Loïc, additional, Winer, Norbert, additional, Legendre, Guillaume, additional, Desbriere, Raoul, additional, Girault, Aude, additional, Pozzi, Jordan, additional, Gachon, Bertrand, additional, Barjat, Thiphaine, additional, Perrotin, Franck, additional, Brunet-Houdard, Solène, additional, and Diguisto, Caroline, additional

Published
2023
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23. Cancer-associated Mutations in Congenital Pulmonary Malformations: A Prospective Cohort

Author

Garinet, Simon, primary, Rahshenas, Makan, additional, Galmiche-Rolland, Louise, additional, Abbo, Olivier, additional, Bonnard, Arnaud, additional, Hameury, Frédéric, additional, Khen-Dunlop, Naziha, additional, Khoshnood, Babak, additional, Blons, Hélène, additional, Delacourt, Christophe, additional, Boudjemaa, Sabah, additional, Choupeaux, Laure, additional, Collardeau-Frachon, Sophie, additional, Fouquet, Virginie, additional, Habonimana, Edouard, additional, Hervieux, Erik, additional, Lelong, Nathalie, additional, Levard, Guillaume, additional, Molina, Thierry Jo, additional, Picard, Cecile, additional, Piolat, Christophe, additional, Sfeir, Rony, additional, Biquard, Florence, additional, Bory, Jean-Paul, additional, Goffinet, François, additional, As, Valat-Rigot, additional, Winer, Norbert, additional, Mousty, Eve, additional, Muszynski, Charles, additional, Benachi, Alexandra, additional, Salomon, Laurent J., additional, Goua, Valérie, additional, Jouannic, Jean-Marie, additional, Bouar, Gwenaelle Le, additional, Massardier, Jérôme, additional, Rosenblatt, Jonathan, additional, Sartor, Agnès, additional, Thong-Vanh, Catherine, additional, Prieur, Fabienne, additional, Quibel, Thibaud, additional, Touboul, Claudine, additional, Gondry, Jean, additional, Sentilhes, Loic, additional, Bonfiglioli, Valérie, additional, Carbillon, Lionel, additional, Saliou, Anne-Helene, additional, Saada, Julien, additional, Letourneau, Alexandra, additional, Laurichesse, Helene, additional, Egron, Carole, additional, Deslandes, Loren, additional, Castaigne, Vanina, additional, Dazel-Salonne, Claire, additional, Stirnemann, Julien, additional, Roth, Philippe, additional, Bultez, Thierry, additional, Ville, Yves, additional, Tsatsaris, Vassilis, additional, Guilbaud, Lucie, additional, Darras, Anne-Marie, additional, Oury, Jean-Francois, additional, Fanget, Cecile, additional, Favre, Romain, additional, Paris, Anne, additional, Perrotin, Franck, additional, Banaszkiewicz, Nathalie, additional, Rakza, Thameur, additional, Morin, Mathieu, additional, Trastour, Cynthia, additional, Mottet, Nicolas, additional, Coatleven, Frederic, additional, Alanio, Elisabeth, additional, Morel, Olivier, additional, Perdriolle, Estelle, additional, Eszto-Cambon, Marie-Laure, additional, Berrazaga, Insaf, additional, Podevin, Guillaume, additional, Feghali, Hala, additional, Thumerelle, Caroline, additional, Mangione, Rafaelle, additional, Lebras, Marie-Noelle, additional, Ducoin, Héloise, additional, Romeo, Bernard, additional, Buisson, Philippe, additional, Cros, Pierrick, additional, Roditis, Léa, additional, Devries, Hiline, additional, Brouard, Jacques, additional, Petit, Thierry, additional, Petit, Isabelle, additional, Simo, Adam Kandem, additional, Pons, Maguelonne, additional, Jaby, Olivier, additional, Llerena, Catherine, additional, Sabatier, Edith, additional, Thouvenin, Guillaune, additional, Larroquet, Michele, additional, Irtan, Sabine, additional, Grapin, Christine, additional, Parico, Caroline, additional, Varlet, François, additional, Matis, Jacqueline, additional, Becmeur, François, additional, Gibertini, Isabelle, additional, Lardy, Hubert, additional, Denapolicocci, Stephan, additional, Deschildre, Antoine, additional, Breaud, Jean, additional, Lecompte, Jean-François, additional, Kamdem, Arnaud Fotso, additional, Elbaz, Frédéric, additional, Lavrand, Frédéric, additional, Pomedio, Mickael, additional, Lefebvre, Francis, additional, Lemelle, Jean Louis, additional, Gomola, Vladimir, additional, Vigier, Clementine, additional, and Monier, Isabelle, additional

Published
2023
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24. Cervical ripening in prolonged pregnancies by silicone double balloon catheter versus vaginal dinoprostone slow release system: The MAGPOP randomised controlled trial

Author

Diguisto, Caroline, Le Gouge, Amélie, Arthuis, Chloé, Winer, Norbert, Parant, Olivier, Poncelet, Christophe, Chauleur, Celine, Hannigsberg, Jacob, Ducarme, Guillaume, Gallot, Denis, Gabriel, Rene, Desbriere, Raoul, Beucher, Gael, Faraguet, Cyrille, Isly, Helene, Rozenberg, Patrick, Giraudeau, Bruno, and Perrotin, Franck

Subjects
Balloon dilatation -- Usage -- Comparative analysis, Pregnancy, Protracted -- Care and treatment, Dinoprostone -- Dosage and administration -- Comparative analysis, Labor, Induced (Obstetrics) -- Methods, Biological sciences
Abstract

Background Prolonged pregnancies are a frequent indication for induction of labour. When the cervix is unfavourable, cervical ripening before oxytocin administration is recommended to increase the likelihood of vaginal delivery, but no particular method is currently recommended for cervical ripening of prolonged pregnancies. This trial evaluates whether the use of mechanical cervical ripening with a silicone double balloon catheter for induction of labour in prolonged pregnancies reduces the cesarean section rate for nonreassuring fetal status compared with pharmacological cervical ripening by a vaginal pessary for the slow release of dinoprostone (prostaglandin E2). Methods and findings This is a multicentre, superiority, open-label, parallel-group, randomised controlled trial conducted in 15 French maternity units. Women with singleton pregnancies, a vertex presentation, [greater than or equal to]41+0 and [less than or equal to]42+0 weeks' gestation, a Bishop score Conclusions In this study, we observed no difference in the rates of cesarean deliveries for nonreassuring fetal status between mechanical ripening with a silicone double balloon catheter and pharmacological cervical ripening with a pessary for the slow release of dinoprostone. Trial registration ClinicalTrials.gov NCT02907060., Author(s): Caroline Diguisto 1,2,3,*, Amélie Le Gouge 4, Chloé Arthuis 5, Norbert Winer 5, Olivier Parant 6, Christophe Poncelet 7,8, Celine Chauleur 9,10, Jacob Hannigsberg 11, Guillaume Ducarme 12, Denis [...]

Published
2021
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26. Tranexamic Acid for the Prevention of Blood Loss After Vaginal Delivery

Author

Sentilhes, Loïc, Winer, Norbert, Azria, Elie, Sénat, Marie-Victoire, Le Ray, Camille, Vardon, Delphine, Perrotin, Franck, Desbrière, Raoul, Fuchs, Florent, Kayem, Gilles, Ducarme, Guillaume, Doret-Dion, Muriel, Huissoud, Cyril, Bohec, Caroline, Deruelle, Philippe, Darsonval, Astrid, Chrétien, Jean-Marie, Seco, Aurélien, Daniel, Valérie, and Deneux-Tharaux, Catherine

Published
2019
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27. Induction of labour versus expectant management for large-for-date fetuses: a randomised controlled trial

Author

Boulvain, Michel, Senat, Marie-Victoire, Perrotin, Franck, Winer, Norbert, Beucher, Gael, Subtil, Damien, Bretelle, Florence, Azria, Elie, Hejaiej, Dominique, Vendittelli, Françoise, Capelle, Marianne, Langer, Bruno, Matis, Richard, Connan, Laure, Gillard, Philippe, Kirkpatrick, Christine, Ceysens, Gilles, Faron, Gilles, Irion, Olivier, and Rozenberg, Patrick

Published
2015
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28. Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial

Author

Bistervels, Ingrid M, primary, Buchmüller, Andrea, additional, Wiegers, Hanke M G, additional, Ní Áinle, Fionnuala, additional, Tardy, Bernard, additional, Donnelly, Jennifer, additional, Verhamme, Peter, additional, Jacobsen, Anne F, additional, Hansen, Anette T, additional, Rodger, Marc A, additional, DeSancho, Maria T, additional, Shmakov, Roman G, additional, van Es, Nick, additional, Prins, Martin H, additional, Chauleur, Céline, additional, Middeldorp, Saskia, additional, van den Akker, Eline S, additional, Bekker, Mireille N, additional, van Bemmel, Thomas, additional, Bertoletti, Laurent, additional, Blanc, Julie, additional, Bleker, Suzanne M, additional, Bourtembourg-Matras, Aude, additional, Bretelle, Florence, additional, Byrne, Bridgette, additional, Couturaud, Francis, additional, Delorme, Pierre, additional, Eerenberg, Elise S, additional, Franssen, Maureen TM, additional, Fuglsang, Jens, additional, Ganzevoort, Wessel, additional, Goffinet, François, additional, de Haan-Jebbink, Jiska M, additional, Heidema, Wieteke, additional, Hertzberg, Monique A, additional, Hovens, Marcel MC, additional, Huisman, Menno V, additional, de Jong-Speksnijder, Leonie, additional, Kamphuisen, Pieter-Willem, additional, O'Keeffe, Denis J, additional, Lacut, Karine, additional, Langenveld, Josje, additional, Lunshof, M Simone, additional, Martens, Caroline P, additional, Merah, Adel, additional, Le Moigne, Emmanuelle, additional, Papatsonis, Dimitri NM, additional, Pernod, Gilles, additional, Perrotin, Franck, additional, Peynaud-Debayle, Edith, additional, Pierre, Fabrice, additional, Plu Bureau, Geneviève, additional, Raia-Barjat, Tiphaine, additional, Rijnders, Robbert JP, additional, Rosario, Roger, additional, Ruivard, Marc, additional, Schmidt, Jeannot, additional, Sueters, Marieke, additional, Vanassche, Thomas, additional, Varlet, Marie-Noëlle, additional, Vivanti, Alexandre J, additional, van der Vlist, Matthieu Y, additional, van der Voet, Lucet F, additional, Vollebregt, Karlijn C, additional, de Vries, Johanna IP, additional, de Weerd, Sabina, additional, Westerweel, Peter E, additional, Wijnberger, Lia DE, additional, ten Wolde, Marije, additional, Ypma, Paula F, additional, Zuily-Lamy, Catherine, additional, Zwart, Joost J, additional, Benachi, Alexandra, additional, Beucher, Gaël, additional, Bezanahary, Holy, additional, de Boer, Karin, additional, de Boer, Marjon A., additional, Bousquet, Frantz, additional, Bremer, Henk A., additional, Bressollette, Luc, additional, Brossard, Aurélie, additional, Chau, Cécile, additional, Cleary, Brian, additional, Comte, Fabienne, additional, Corsini, Thomas, additional, Coustel, Anne, additional, Debaveye, Barbara, additional, Desbrière, Raoul, additional, Duvillard, Cécile, additional, Eckman, Astrid, additional, Eikenboom, Jeroen, additional, Elias, Antoine, additional, Faber, Laura M., additional, Ferrari, Emile, additional, Gallot, Denis, additional, Gauchotte, Emilie, additional, Gaugler, Ingrid, additional, Geerlings, Abby E., additional, O'Gorman, Audrey, additional, Grobost, Vincent, additional, de Groot, Pieter-Kees, additional, van der Ham, David P., additional, Hermsen, Brenda, additional, Kamphorst, Kim, additional, Karovitch, Alan, additional, Kleiverda, Gunilla, additional, Kloster, Aiste, additional, Koops, Annemarieke, additional, Krabbendam, Inneke, additional, Kruip, Marieke J.H.A., additional, Kuipers, Saskia, additional, van Laar, Judith, additional, Laneelle, Damien, additional, Lima, Suzanne, additional, MacMahon, Peter, additional, Mandelbrot, Laurent, additional, van Meir, Claudia A., additional, Menez, Caroline, additional, Morssink, Leonard P., additional, Moulin, Nathalie, additional, Mousty, Eve, additional, Muller, Matthieu, additional, Murphy, Lucy, additional, Peerlinck, Kathelijne, additional, O'Reilly, Alma, additional, de Reus, Maartje, additional, Le Roux, Magali Hilmi, additional, Ryan, Kevin, additional, Samren, Bettina, additional, Schippers, Daniela, additional, Schuitemaker, Nico, additional, Schweizer, Chloé, additional, van der Straaten, Hanneke, additional, Tromeur, Cécile, additional, Vanheule, Kristine, additional, Verhagen, Tamara, additional, Visser, Jantien, additional, Watts, Michael, additional, van Wijngaarden, Wim J., additional, Woiski, Mallory, additional, and Zelis, Maartje, additional

Published
2022
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29. Low-dose aspirin to prevent preeclampsia and growth restriction in nulliparous women identified by uterine artery Doppler as at high risk of preeclampsia: A double blinded randomized placebo-controlled trial

Author

Diguisto, Caroline, Le Gouge, Amelie, Marchand, Marie-Sara, Megier, Pascal, Ville, Yves, Haddad, Georges, Winer, Norbert, Arthuis, Chloé, Doret, Muriel, Debarge, Veronique Houfflin, Flandrin, Anaig, Delmas, Hélène Laurichesse, Gallot, Denis, Mares, Pierre, Vayssiere, Christophe, Sentilhes, Loïc, Cheve, Marie-Therese, Paumier, Anne, Durin, Luc, Schaub, Bruno, Equy, Veronique, Giraudeau, Bruno, Perrotin, Franck, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Maternité Olympe de Gouges [CHRU Tours], Centre d’Investigation Clinique [Tours] CIC 1415 (CIC ), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Régional d'Orléans (CHRO), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), CHU Lille, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Clermont-Ferrand, Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Aix-Marseille Université - École de maïeutique (AMU SMPM EM), Aix-Marseille Université - Faculté des sciences médicales et paramédicales (AMU SMPM), Aix Marseille Université (AMU)-Aix Marseille Université (AMU), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Centre Hospitalier Le Mans (CH Le Mans), Polyclinique de l’Atlantique, Partenaires INRAE, Elsan Polyclinique du Parc - Caen, CHU de la Martinique [Fort de France], CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, and Université de Tours (UT)

Subjects
Male, Uterine Artery, Pregnancy Trimester, First, Multidisciplinary, Pre-Eclampsia, Aspirin, Pregnancy, [SDV]Life Sciences [q-bio], Infant, Newborn, Humans, Birth Weight, Female
Abstract

Introduction This trial evaluates whether daily low-dose aspirin initiated before 16 weeks of gestation can reduce preeclampsia and fetal growth restriction in nulliparous women identified by first-trimester uterine artery Dopplers as at high risk of preeclampsia. Methods This randomized, blinded, placebo-controlled, parallel-group trial took place in 17 French obstetric departments providing antenatal care. Pregnant nulliparous women aged ≥ 18 years with a singleton pregnancy at a gestational age < 16 weeks of gestation with a lowest pulsatility index ≥ 1.7 or a bilateral protodiastolic notching for both uterine arteries on an ultrasound performed between 11+0 and 13+6 weeks by a certified sonographer were randomized at a 1:1 ratio to 160 mg of low-dose aspirin or to placebo to be taken daily from inclusion to their 34th week of gestation. The main outcome was preeclampsia or a birthweight ≤ 5th percentile. Other outcomes included preeclampsia, severe preeclampsia, preterm preeclampsia, preterm delivery before 34 weeks, mode of delivery, type of anesthesia, birthweight ≤ 5th percentile and perinatal death. Results The trial was interrupted due to recruiting difficulties. Between June 2012 and June 2016, 1104 women were randomized, two withdrew consent, and two had terminations of pregnancies. Preeclampsia or a birthweight ≤ 5th percentile occurred in 88 (16.0%) women in the low-dose aspirin group and in 79 (14.4%) in the placebo group (proportion difference 1.6 [-2.6; 5.9] p = 0.45). The two groups did not differ significantly for the secondary outcomes. Conclusion Low-dose aspirin was not associated with a lower rate of either preeclampsia or birthweight ≤ 5th percentile in women identified by their first-trimester uterine artery Doppler as at high risk of preeclampsia. Trial registration (NCT0172946).

Published
2022

30. Neonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial

Author

Schmitz, Thomas, primary, Doret-Dion, Muriel, additional, Sentilhes, Loic, additional, Parant, Olivier, additional, Claris, Olivier, additional, Renesme, Laurent, additional, Abbal, Julie, additional, Girault, Aude, additional, Torchin, Héloïse, additional, Houllier, Marie, additional, Le Saché, Nolwenn, additional, Vivanti, Alexandre J, additional, De Luca, Daniele, additional, Winer, Norbert, additional, Flamant, Cyril, additional, Thuillier, Claire, additional, Boileau, Pascal, additional, Blanc, Julie, additional, Brevaut, Véronique, additional, Bouet, Pierre-Emmanuel, additional, Gascoin, Géraldine, additional, Beucher, Gaël, additional, Datin-Dorriere, Valérie, additional, Bounan, Stéphane, additional, Bolot, Pascal, additional, Poncelet, Christophe, additional, Alberti, Corinne, additional, Ursino, Moreno, additional, Aupiais, Camille, additional, Baud, Olivier, additional, Boize, Philippe, additional, Garabédian, Charles, additional, Flamein, Florence, additional, Le Lous, Maela, additional, Beuchée, Alain, additional, Gondry, Jean, additional, Tourneux, Pierre, additional, Coste-Mazeau, Perrine, additional, Bedu, Antoine, additional, Gallot, Denis, additional, Coste, Karen, additional, Chauleur, Céline, additional, Patural, Hugues, additional, Kayem, Gilles, additional, Mitanchez, Delphine, additional, Heckenroth, Hélène, additional, Boubred, Farid, additional, Sibiude, Jeanne, additional, Desfrère, Luc, additional, Bohec, Caroline, additional, Mansir, Thierry, additional, Koch, Antoine, additional, Kuhn, Pierre, additional, Tillouche, Nadia, additional, Lapeyre, Fabrice, additional, Perrotin, Franck, additional, Favrais, Géraldine, additional, Lecarpentier, Edouard, additional, Durrmeyer, Xaxier, additional, Equy, Véronique, additional, Debillon, Thierry, additional, Rigonnot, Luc, additional, Lefoulgoc, Stéphanie, additional, Brie, Claudia, additional, Pagès, Anne-Sophie, additional, Rayssiguier, Romy, additional, Cambonie, Gilles, additional, Cudeville, Corinne, additional, Madeleneau, Doriane, additional, Morel, Olivier, additional, Hascoet, Jean-Michel, additional, Letouzey, Vincent, additional, Di Maio, Massimo, additional, Salomon, Laurent J., additional, and Lapillonne, Alexandre, additional

Published
2022
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31. Tranexamic acid for the prevention of postpartum hemorrhage after vaginal delivery: the TRAAP trial: 1

Author

Sentilhes, Loïc, Winer, Norbert, Azria, Elie, Sénat, Marie-Victoire, Le Ray, Camille, Vardon, Delphine, Perrotin, Franck, Desbrière, Raoul, Fuchs, Florent, Kayem, Gilles, Ducarme, Guillaume, Doret-Dion, Muriel, Huissoud, Cyril, Bohec, Caroline, Deruelle, Philippe, Darsonval, Astrid, Chrétien, Jean-Marie, Séco, Aurélien, Daniel, Valérie, and Deneux-Tharaux, Catherine

Published
2018
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32. Serial plotting of symphysis–fundal height and estimated fetal weight to improve the antenatal detection of infants small for gestational age: A cluster randomised trial.

Author

Ego, Anne, Monier, Isabelle, Vilotitch, Antoine, Kayem, Gilles, Vayssiere, Christophe, Verspyck, Eric, Zeitlin, Jennifer, Barjat, Tiphaine, Bretelle, Florence, Debarge, Véronique, Grangé, Gilles, Guillaume, Benoist, Heckenroth, Hélène, Hoffmann, Pascale, Mandelbrot, Laurent, Perrotin, Franck, Rozenberg, Patrick, Sananes, Nicolas, Schmitz, Thomas, and Sénat, Marie‐Victoire

Subjects
SMALL for gestational age, FETAL growth retardation, DELIVERY (Obstetrics), INFANTS, PRENATAL care, FETAL macrosomia
Abstract

Objective: To assess whether standardised longitudinal reporting of growth monitoring information improves antenatal detection of infants who are small for gestational age (SGA), compared with usual care. Design: Cluster‐randomised controlled trial. Setting: Sixteen French level‐3 units in 2018–2019. Population: Singleton pregnancies. Methods: The intervention consisted of the serial plotting of symphysis–fundal height (SFH) and estimated fetal weight (EFW) measurements on customised growth charts using a software program, compared with standard antenatal care. We estimated relative risks (RR) adjusted for known risk factors for fetal growth restriction (FGR). Main Outcome Measures: The primary outcome was antenatal detection of FGR among SGA births (with birthweights below the tenth centile of French customised curves), defined as the mention of suspected FGR in medical records and either referral ultrasounds for growth monitoring or indicated delivery for FGR. Secondary outcomes were false‐positive rates, mode of delivery, perinatal morbidity and mortality, and number of antenatal visits and ultrasounds. Results: In total, seven intervention clusters (n = 4349) and eight control clusters (n = 4943) were analysed, after the exclusion of one intervention centre for a major deviation in protocol. SGA births represented 613 (14.1%) and 626 (12.7%) of all births, respectively. The rates of antenatal detection of FGR among SGA births were 40.0% in the intervention arm versus 37.1% in the control arm (crude RR 1.08, 95% CI 0.87–1.34; adj RR 1.09, 95% CI 0.88–1.35). No benefits of the intervention were detected in the analyses of secondary outcomes. Conclusions: Serial plotting of SFH and EFW measurements on customised growth charts did not improve the antenatal detection of FGR among SGA births. Linked article: This article is commented on by Kiserud, pp. 740 in this issue. To view this mini commentary visit https://doi.org/10.1111/1471‐0528.17416. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Conservative management or cesarean hysterectomy for placenta accreta spectrum: the PACCRETA prospective study

Author

Sentilhes, Loïc, primary, Seco, Aurélien, additional, Azria, Elie, additional, Beucher, Gaël, additional, Bonnet, Marie-Pierre, additional, Branger, Bernard, additional, Carbillon, Lionel, additional, Chiesa, Coralie, additional, Crenn-Hebert, Catherine, additional, Dreyfus, Michel, additional, Dupont, Corinne, additional, Fresson, Jeanne, additional, Huissoud, Cyril, additional, Langer, Bruno, additional, Morel, Olivier, additional, Patrier, Sophie, additional, Perrotin, Franck, additional, Raynal, Pierre, additional, Rozenberg, Patrick, additional, Rudigoz, René-Charles, additional, Vendittelli, Francoise, additional, Winer, Norbert, additional, Deneux-Tharaux, Catherine, additional, Kayem, Gilles, additional, Avril, Isabelle, additional, Bazire, Sophie, additional, Bedel, Sophie, additional, De Marcillac, Fanny, additional, Gaucher, Laurent, additional, Guitton, Maëlle, additional, Guerin, Catherine, additional, Lecomte, Laurence, additional, Pranal, Marine, additional, Rault, Laetitia, additional, Viallon, Anne, additional, Virlouvet, Myriam, additional, and Schwanka, Justine, additional

Published
2022
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35. Sentilhes L, Sénat M.V, Bouchghoul H, Delorme P, Gallot D, Garabedian C, Madar H, Sananès N, Perrotin F, Schmitz T. Réponse à l’article de Boujenah J. intitulé « La cholestase gravidique : pour une vision holistique de la femme. À propos des examens complémentaires lors du diagnostic ». Gynecol Obstet Fertil 2024;52(6). doi:10.1016/j.gofs.2024.02.023

Author

Sentilhes, Loïc, Sénat, Marie-Victoire, Bouchghoul, Hanane, Delorme, Pierre, Gallot, Denis, Garabedian, Charles, Madar, Hugo, Sananès, Nicolas, Perrotin, Franck, and Schmitz, Thomas

Published
2024
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36. Oral misoprostol tablets (25 µg) for induction of labor: a targeted literature review and cost analysis

Author

Poinas, Anne-Claire, Padgett, Katherine, de Heus, Roel, Perrotin, Franck, and Devlieger, Roland

Subjects
misoprostol, obstetrics, I00, Health Policy, costs, Administration, Oral, oral misoprostol, A10, Pregnancy, Oxytocics, Costs and Cost Analysis, Humans, Female, Labor, Induced, A1, Induction of labor, Misoprostol, Retrospective Studies, Tablets
Abstract

BACKGROUND: Various methods exist for the induction of labor (IOL), and there is limited consensus as to optimal methods. Off-label misoprostol is recommended by the World Health Organization (WHO) for IOL but preparing it into doses suitable for IOL lacks precision, with potential adverse outcomes if dosing is inaccurate. This study explores potential outcomes and costs associated with increased uptake of a low-dose (25 µg) oral misoprostol formulation (Angusta; Norgine BV, Amsterdam) approved for IOL, in France, Belgium, and the Netherlands. METHODS: A literature review was undertaken to derive probabilities of delivery outcomes (vaginal, instrumental, and cesarean sections) for IOL methods, from published meta-analyses. Outcomes for oral misoprostol tablets (25 µg) were unavailable in the meta-analyses, so were estimated using data from two published retrospective cohort studies. A model was developed to predict the frequency of IOL outcomes and associated costs at the national level, across multiple scenarios. Scenarios were tested using a moderate, medium, and high increase in oral misoprostol tablet (25 µg) uptake. Market shares, costs, and induction rates were defined for each country using multiple data sources. RESULTS: Increased uptake of oral misoprostol tablets (25 µg) was estimated to be associated with a slightly increased rate of routine vaginal deliveries, and concurrent decreases in instrumental vaginal deliveries and cesarean sections. Since routine vaginal deliveries are less costly than other delivery outcomes, increased uptake of oral misoprostol tablets (25 µg) within the IOL market has the potential to be cost-saving. These trends were predicted using 25 µg oral misoprostol tablet outcomes informed by both retrospective studies. CONCLUSION: Preliminary outcomes suggest that oral misoprostol tablets at 25 µg per dose may improve outcomes in IOL and be cost-saving. Further study is required to validate these findings and assess the comparative efficacy of IOL methods, including oral misoprostol tablets (25 µg). ispartof: JOURNAL OF MEDICAL ECONOMICS vol:25 issue:1 pages:428-436 ispartof: location:England status: accepted

Published
2022
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37. Association Between Planned Cesarean Delivery and Neonatal Mortality and Morbidity in Twin Pregnancies

Author

Schmitz, Thomas, Prunet, Caroline, Azria, Elie, Bohec, Caroline, Bongain, André, Chabanier, Pierre, DʼErcole, Claude, Deruelle, Philippe, De Tayrac, Renaud, Dreyfus, Michel, Dupont, Corinne, Gondry, Jean, Graesslin, Olivier, Kayem, Gilles, Langer, Bruno, Marpeau, Loïc, Morel, Olivier, Parant, Olivier, Perrotin, Franck, Pierre, Fabrice, Poulain, Patrice, Riethmuller, Didier, Rozenberg, Patrick, Rudigoz, René-Charles, Sagot, Paul, Sénat, Marie-Victoire, Sentilhes, Loïc, Vayssière, Christophe, Venditelli, Françoise, Verspyck, Eric, Winer, Norbert, Lecomte-Raclet, Laurence, Ancel, Pierre-Yves, and Goffinet, François

Published
2017
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38. Neonatal twin outcomes according to the planned mode of delivery: a national prospective population-based cohort study with propensity score analysis: 99

Author

Schmitz, Thomas, Prunet, Caroline, Azria, Elie, Bongain, André, Chabanier, Pierre, dʼErcole, Claude, Deruelle, Philippe, de Tayrac, Renaud, Dreyfus, Michel, Dupont, Corinne, Gondry, Jean, Kayem, Gilles, Langer, Bruno, Marpeau, Loic, Morel, Olivier, Perrotin, Franck, Pierre, Fabrice, Riethmuller, Didier, Sénat, Marie-Victoire, Sentilhes, Loic, Vayssière, Christophe, Winer, Norbert, Ancel, Pierre-Yves, and Goffinet, François

Published
2017
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40. A comparison of balloon catheters and vaginal prostaglandins for cervical ripening prior to labour induction

Author

Jones, Madeleine, primary, Palmer, Kirsten, additional, Pathirana, Maleesa M., additional, Cecatti, Jose Guilherme, additional, Moraes Filho, Olimpio B., additional, Marions, Lena, additional, Prager, Martina, additional, Edlund, Måns, additional, Jozwiak, Marta, additional, Eikelder, Mieke Ten, additional, Rengerink, Katrien Oude, additional, Bloemenkamp, Kitty W.M., additional, Henry, Amanda, additional, Beckmann, Mike, additional, Kumar, Sailesh, additional, Diguisto, Caroline, additional, Le Gouge, Amélie, additional, Perrotin, Franck, additional, Symonds, Ian, additional, O'Leary, Sean, additional, Rolnik, Daniel L., additional, Mol, Ben W., additional, and Li, Wentao, additional

Published
2022
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41. Infection in Patients with Suspected Thrombotic Microangiopathy Based on Clinical Presentation

Author

Thoreau, Benjamin, primary, von Tokarski, Florent, additional, Bauvois, Adeline, additional, Bayer, Guillaume, additional, Barbet, Christelle, additional, Cloarec, Sylvie, additional, Mérieau, Elodie, additional, Lachot, Sébastien, additional, Garot, Denis, additional, Bernard, Louis, additional, Gyan, Emmanuel, additional, Perrotin, Franck, additional, Pouplard, Claire, additional, Maillot, François, additional, Gatault, Philippe, additional, Sautenet, Bénédicte, additional, Rusch, Emmanuel, additional, Frémeaux-Bacchi, Véronique, additional, Vigneau, Cécile, additional, Fakhouri, Fadi, additional, and Halimi, Jean-Michel, additional

Published
2021
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42. Shear wave velocity dispersion analysis in placenta using 2-D transient elastography.

Author

Callé, Samuel, Simon, Emmanuel, Dumoux, Marie-Coline, Perrotin, Franck, and Remenieras, Jean-Pierre

Subjects
PREECLAMPSIA, FETAL development, PLACENTA, ELASTOGRAPHY, MODULUS of rigidity
Abstract

Preeclampsia and intrauterine growth restriction are related to placental insufficiency and constitute a major public health challenge. Significant changes in placental microarchitecture have already been described in these situations, including, for example, increases or decreases in the number of villi ramifications and the presence of fibrin deposits in terms of villi. These changes affect the entire placenta and might lead to variations in elasticity compared to normal placentas. In this context, we proposed to develop a 2-D transient elastography system, dedicated to the placenta and adapted for in vivo measurements, based on the coupling of a shear wave generated by an external vibration and ultrasound images acquired at an ultrafast rate. To be particularly sensitive to the structure of this organ, a frequency analysis of the complex shear modulus has been realized by applying a fractional rheological model. This model provides a parameter n which could be sensitive to a shape factor, for example, the variations in the number of villi ramifications in the case of placental insufficiency. An ex vivo feasibility of the method on 20 normal placentas is presented in this work. [ABSTRACT FROM AUTHOR]

Published
2018
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43. Liste des collaborateurs

Author

Acker, Olivier, primary, Autret-Leca, Élisabeth, additional, Ayeva-Derman, Michael, additional, Bénichou, Renaud, additional, Body, Gilles, additional, Brun, Jean-Luc, additional, Chevillot, Muriel, additional, Ciavaldini, Jean-François, additional, Cissoko, Hawaré, additional, Cornuau, Marion, additional, Couet, Charles, additional, De Poncheville, Loïc, additional, Descamps, Philippe, additional, El Hage, Wissam, additional, Farad-Bensenouci, Samia, additional, Fignon, Alain, additional, Fournié, Alain, additional, Geoffrion, Hugues, additional, Golfier, François, additional, Gonnet, Jean-Marie, additional, Guyot, Hervé, additional, Gras, Guillaume, additional, Gruel, Yves, additional, Jacquet, Annie, additional, Jonville-Béra, Anne-Pierre, additional, Jourdain, Olivier, additional, Lansac, Jacques, additional, Lehr Drylewicz, Anne-Marie, additional, Levêque, Jean, additional, Lionnet, Corinne, additional, Maillot, François, additional, Marret, Henri, additional, Mesrine, Sylvie, additional, Perrotin, Franck, additional, Potin, Jérôme, additional, Ramos, Anna, additional, Roussillon, Emmanuel, additional, Saint Martin, Pauline, additional, Schiano, Alain, additional, Simon, Emmanuel, additional, Trignol-Viguier, Nathalie, additional, Vaudoyer, Fabien, additional, and Wagner-Ballon, Jacques, additional

Published
2014
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44. Liste des collaborateurs

Author

Affres, Hélène, primary, Amar, Laurence, additional, Amate, Pascale, additional, Annane, Djillali, additional, Azria, Elie, additional, Benachi, Alexandra, additional, Berlin, Ivan, additional, Bernuau, Jacques, additional, Bobrie, Guillaume, additional, Boleslawski, Emmanel, additional, Bonneau, Claire, additional, Bornes, Marie, additional, Bouhnik, Yoram, additional, Bouteloup, Corinne, additional, Bouvet, Elisabeth, additional, Brémond-Gignac, Dominique, additional, Bresset, Arnaud, additional, Bretelle, Florence, additional, Bricaire, Léopoldine, additional, Bruyere, Marie, additional, Ceccaldi, Pierre-François, additional, Chanson, Philippe, additional, Chauvet, Sophie, additional, Clair, Bernard, additional, Clouqueur, Élodie, additional, Cohen, Sarah, additional, Conard, Jacqueline, additional, Comarmond, Cloé, additional, Conquy, Sophie, additional, Copin, Henri, additional, Cordier, Anne-Gaël, additional, Cordiez, Sophie, additional, Costedoat-Chalumeau, Nathalie, additional, Daraï, Emile, additional, Delabaere, Amélie, additional, Deruelle, Philippe, additional, Dommergues, Marc, additional, Dreyfus, Marie, additional, Dubertret, Caroline, additional, Du-Boutin, Lê Thi Huong, additional, Ducarme, Guillaume, additional, Ducloy-Bouthors, Anne-Sophie, additional, Le Pointe, Hubert Ducou, additional, Duranteau, Lise, additional, Fakhouri, Fadi, additional, Fernandez, Hervé, additional, Ferrand, Hélène, additional, Filippova, Julia, additional, Fior, Renato, additional, Frank, Michael, additional, Friedman, Diane, additional, Galacteros, Frédéric, additional, Gallot, Denis, additional, Garcia, Gilles, additional, Gauvrit, Jean-Yves, additional, Gervais, Anne, additional, Girot, Robert, additional, Godeau, Bertrand, additional, Grangé, Gilles, additional, Grenet, Dominique, additional, Groussin, Lionel, additional, Guettrot-Imbert, Gaëlle, additional, Habibi, Anoosha, additional, Hadj-Rabia, Smail, additional, Hermine, Olivier, additional, Houfflin-Debarge, Véronique, additional, Houyel, Lucile, additional, Hugon-Rodin, Justine, additional, Humbert, Marc, additional, Iserin, Laurence, additional, Iung, Bernard, additional, Jaïs, Xavier, additional, Joly, Bérangère, additional, Jondeau, Guillaume, additional, Kahn, Jean-Emmanuel, additional, Kayem, Gilles, additional, Keita, Hawa, additional, Keller, Valentin, additional, Ladouceur, Magalie, additional, Legardeur, Hélène, additional, Le Guern, Véronique, additional, Lejeune, Claude, additional, Le Jeunne, Claire, additional, Le Ray, Camille, additional, Luton, Dominique, additional, Manamani-Bererhi, Lynda, additional, Mandelbrot, Laurent, additional, Marie, Isabelle, additional, Matheron, Sophie, additional, Maulard, Amandine, additional, Merbai, Nadia, additional, Messas, Emmanuel, additional, De Miranda, Sandra, additional, Morgant, Stéphanie, additional, Msika, Simon, additional, Nebout, Sophie, additional, Nedellec, Sophie, additional, Nizard, Jacky, additional, d'Oiron, Roseline, additional, Ozenne, Violaine, additional, Perlemuter, Gabriel, additional, Perrouin-Verbe, Brigitte, additional, Perrotin, Franck, additional, Peynaud-Debayle, Edith, additional, Philippe, Henri-Jean, additional, Picard, Clément, additional, Picone, Olivier, additional, Pigeyre, Marie, additional, Plouin, Pierre-François, additional, Plu-Bureau, Geneviève, additional, Polivka, Laura, additional, Poulain, Patrice, additional, de Pradier, Marie, additional, Raccah-Tebeka, Brigitte, additional, Ribeil, Jean-Antoine, additional, Rouzier, Roman, additional, Ronziere, Thomas, additional, Rossi, Aude, additional, Saadoun, David, additional, Selleret, Lise, additional, Sellier, Pierre, additional, Sénat, Marie-Victoire, additional, Subtil, Damine, additional, Taillé, Camille, additional, Therby, Denis, additional, Tô, Ngoc-Tram, additional, de Toffol, Bertrand, additional, Trillot, Nathalie, additional, Tsatsaris, Vassilis, additional, Tuyeras, Géraud, additional, Valentin, Morgane, additional, Vambergue, Anne, additional, Vandendriessche, David, additional, Verspyck, Eric, additional, Vincent-Rohfritsch, Aurélie, additional, Voltzenlogel, Marie-Catherine, additional, Vukusic, Sandra, additional, Wechsler, Bernard, additional, Winer, Norbert, additional, and Young, Jacques-François, additional

Published
2014
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45. Tranexamic Acid for the Prevention of Blood Loss after Cesarean Delivery

Author

Sentilhes, Loïc, primary, Sénat, Marie V., additional, Le Lous, Maëla, additional, Winer, Norbert, additional, Rozenberg, Patrick, additional, Kayem, Gilles, additional, Verspyck, Eric, additional, Fuchs, Florent, additional, Azria, Elie, additional, Gallot, Denis, additional, Korb, Diane, additional, Desbrière, Raoul, additional, Le Ray, Camille, additional, Chauleur, Céline, additional, de Marcillac, Fanny, additional, Perrotin, Franck, additional, Parant, Olivier, additional, Salomon, Laurent J., additional, Gauchotte, Emilie, additional, Bretelle, Florence, additional, Sananès, Nicolas, additional, Bohec, Caroline, additional, Mottet, Nicolas, additional, Legendre, Guillaume, additional, Letouzey, Vincent, additional, Haddad, Bassam, additional, Vardon, Delphine, additional, Madar, Hugo, additional, Mattuizzi, Aurélien, additional, Daniel, Valérie, additional, Regueme, Sophie, additional, Roussillon, Caroline, additional, Benard, Antoine, additional, Georget, Aurore, additional, Darsonval, Astrid, additional, and Deneux-Tharaux, Catherine, additional

Published
2021
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46. Amniotic fluid peptides predict postnatal kidney survival in developmental kidney disease

Author

Klein, Julie, primary, Buffin-Meyer, Bénédicte, additional, Boizard, Franck, additional, Moussaoui, Nabila, additional, Lescat, Ophélie, additional, Breuil, Benjamin, additional, Fedou, Camille, additional, Feuillet, Guylène, additional, Casemayou, Audrey, additional, Neau, Eric, additional, Hindryckx, An, additional, Decatte, Luc, additional, Levtchenko, Elena, additional, Raaijmakers, Anke, additional, Vayssière, Christophe, additional, Goua, Valérie, additional, Lucas, Charlotte, additional, Perrotin, Franck, additional, Cloarec, Sylvie, additional, Benachi, Alexandra, additional, Manca-Pellissier, Marie-Christine, additional, Delmas, Hélène Laurichesse, additional, Bessenay, Lucie, additional, Le Vaillant, Claudine, additional, Allain-Launay, Emma, additional, Gondry, Jean, additional, Boudailliez, Bernard, additional, Simon, Elisabeth, additional, Prieur, Fabienne, additional, Lavocat, Marie-Pierre, additional, Saliou, Anne-Hélène, additional, De Parscau, Loic, additional, Bidat, Laurent, additional, Noel, Catherine, additional, Floch, Corinne, additional, Bourdat-Michel, Guylène, additional, Favre, Romain, additional, Weingertner, Anne-Sophie, additional, Oury, Jean-François, additional, Baudouin, Véronique, additional, Bory, Jean-Paul, additional, Pietrement, Christine, additional, Fiorenza, Maryse, additional, Massardier, Jérôme, additional, Kessler, Sylvie, additional, Lounis, Nadia, additional, Auriol, Françoise Conte, additional, Marcorelles, Pascale, additional, Collardeau-Frachon, Sophie, additional, Zürbig, Petra, additional, Mischak, Harald, additional, Magalhães, Pedro, additional, Batut, Julie, additional, Blader, Patrick, additional, Saulnier Blache, Jean-Sebastien, additional, Bascands, Jean-Loup, additional, Schaefer, Franz, additional, Decramer, Stéphane, additional, Schanstra, Joost P., additional, Allegaert, Karel, additional, Aubard, Yves, additional, Basmaison, Odile, additional, Benevent, Jean-Baptiste, additional, Biquard, Florence, additional, Champion, Gérard, additional, Delbosc, Jean-Marie, additional, Eckart, Philippe, additional, Froute, Marie-Françoise, additional, Gaucherand, Pascal, additional, Groussolles, Marion, additional, Guigonis, Vincent, additional, Hougas, Blandine, additional, Le Bouar, Gwenaelle, additional, Martin, Alain, additional, Martin, Sophie, additional, Maupin-Hyvonnet, Mariannick, additional, Merveille, Marina, additional, Mousty, Eve, additional, Nobili, François, additional, Ryckewaert, Amelie, additional, Sartor, Agnes, additional, Taque, Sophie, additional, and Winer, Norbert, additional

Published
2021
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47. 485 Efficacy of early versus late intrauterine balloon tamponade in the management of severe postpartum hemorrhage

Author

Rozenberg, Patrick, primary, Sentilhes, Loïc, additional, Winer, Norbert, additional, goffinet, Francois, additional, Vayssiere, Christophe, additional, senat, Marie-Victoire, additional, Morel, Olivier, additional, Haddad, Bassam, additional, Garabédian, Charles, additional, Vivanti, Alexandre, additional, Perrotin, Franck, additional, Kayem, Gilles, additional, Raynal, Pierre, additional, Blanc, Julie, additional, Verspyck, Eric, additional, Gallot, Denis, additional, Sananes, Nicolas, additional, séco, Aurélien, additional, Desbrière, Raoul, additional, and Deneux-Tharaux, Catherine, additional

Published
2021
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49. Additional file 1 of Rationale and design of ePPOP-ID: a multicenter randomized controlled trial using an electronic-personalized program for obesity in pregnancy to improve delivery

Author

Deruelle, Philippe, Lelorain, Sophie, Deghilage, Sylvie, Couturier, Emmanuelle, Guilbert, Elodie, Berveiller, Paul, Sénat, Marie Victoire, Vayssière, Christophe, Sentilhes, Loïc, Perrotin, Franck, Gallot, Denis, Chauleur, Céline, Sananes, Nicolas, Roth, Emmanuel, Luton, Dominique, Caputo, Marie, Lorio, Elodie, Chatelet, Carla, Couster, Julien, Timbely, Oumar, Doret-Dion, Muriel, Duhamel, Alain, and Pigeyre, Marie

Abstract

Additional file 1: Table S1. Content of the e-learning program. Table giving more detailed information about the program

Published
2020
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50. The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design

Author

Buffin-Meyer, Bénédicte, Klein, Julie, van der Zanden, Loes F M, Levtchenko, Elena, Moulos, Panogiotis, Lounis, Nadia, Conte-Auriol, Françoise, Hindryckx, An, Wühl, Elke, Persico, Nicola, Oepkes, Dick, Schreuder, Michiel F, Tkaczyk, Marcin, Ariceta, Gema, Fossum, Magdalena, Parvex, Paloma, Feitz, Wout, Olsen, Henning, Montini, Giovanni, Decramer, Stéphane, Schanstra, Joost P, De Catte, Luc, Vayssieres, Christophe, Sartor, Agnès, Groussolles, Marion, Plard, Christelle, Guerby, Paul, Connan, Laure, Morin, Mathieu, Simon, Elizabeth, Breaud, Jean, Saliou, Anne-Hélène, De Parscau, Loic, Jay, Nadine, Germouty, Isabelle, Le Bouar, Gwenaelle, Ryckewaert, Amelie, Manca-Pellissier, Marie-Christine, Merrot, Thierry, Laurichesse, Helene, Gallot, Denis, Bessenay, Lucie, Bidat, Laurent, Boize, Philippe, Winer, Norbert, Allain-Launey, Emma, Le Vaillant, Claudine, Prieur, Fabienne, Lavocat, Marie-Pierre, Coatleven, Frederic, Debromez, Eric, Harembat, Jérôme, Llanas, Brigitte, Favre, Romain, Moog, Raphael, Zaloszyc, Ariane, Massardier, Jérôme, Demede, Delphine, Perrotin, Franck, Cloarec, Sylvie, Vequeau-Goua, Valérie, Descombes, Emmanuelle, Boulot, Pierre, Morin, Denis, Fuchs, Florent, Tenenbaum, Julie, Ville, Yves, Blanc, Thomas, Heidet, Laurence, Paris, Anne, Dobremez, Eric, Froute, Marie-Françoise, Gondry, Jean, Muszynski, Charles, Haraux, Elodie, Lobelle, Fabienne, Chevreau, Julien, Rosenblatt, Jonathan, Baudoin, Véronique, Deschenes, Georges, Guigue, Virginie, Amblard, Florence, Bourdat-Michel, Guylhène, Schaefer, Franz, Elsässer, Michael, Rossi, Federica, Manzoni, Gianantonio, De Marco, Erika A, Capone, Valentina, Caforio, Leonardo, Zaccara, Antonio, Innocenzi, Michele, Bagolan, Pietro, Capozza, Nicola, Castagnetti, Marco, Mancini, Mariangela, van Scheltema, Phebe Adama, Kortmann, Barbara, Schreuder, Michiel, Stańczyk, Małgorzata, Szaflik, Krzysztof, Wojtera, Justyna, Krzeszowski, Waldemar, Talar, Tomasz, Pawłowska, Barbara, Fortecka-Piestrzeniewicz, Katarzyna, Olejniczak, Dariusz, Arevalo, Silvia, Rodo, Carlota, Lindgren, Peter, Chehade, Hassib, ANTENATAL Consortium, Hindryckx, A., De Catte, L., Vayssieres, C., Sartor, A., Groussolles, M., Plard, C., Guerby, P., Connan, L., Morin, M., Simon, E., Breaud, J., Saliou, A.H., De Parscau, L., Jay, N., Germouty, I., Le Bouar, G., Ryckewaert, A., Manca-Pellissier, M.C., Merrot, T., Laurichesse, H., Gallot, D., Bessenay, L., Bidat, L., Boize, P., Winer, N., Allain-Launey, E., Le Vaillant, C., Prieur, F., Lavocat, M.P., Coatleven, F., Debromez, E., Harembat, J., Llanas, B., Favre, R., Moog, R., Zaloszyc, A., Massardier, J., Demede, D., Perrotin, F., Cloarec, S., Vequeau-Goua, V., Descombes, E., Boulot, P., Morin, D., Fuchs, F., Tenenbaum, J., Ville, Y., Blanc, T., Heidet, L., Paris, A., Dobremez, E., Froute, M.F., Gondry, J., Muszynski, C., Haraux, E., Lobelle, F., Chevreau, J., Rosenblatt, J., Baudoin, V., Deschenes, G., Guigue, V., Amblard, F., Bourdat-Michel, G., Wühl, E., Schaefer, F., Elsässer, M., Persico, N., Rossi, F., Manzoni, G., De Marco, E.A., Montini, G., Capone, V., Caforio, L., Zaccara, A., Innocenzi, M., Bagolan, P., Capozza, N., Castagnetti, M., Mancini, M., Oepkes, D., van Scheltema, P.A., Feitz, W., Kortmann, B., Schreuder, M., Tkaczyk, M., Stańczyk, M., Szaflik, K., Wojtera, J., Krzeszowski, W., Talar, T., Pawłowska, B., Fortecka-Piestrzeniewicz, K., Olejniczak, D., Ariceta, G., Arevalo, S., Rodo, C., Fossum, M., Lindgren, P., Parvex, P., Chehade, H., Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Radboud University Medical Center [Nijmegen], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), HybridStat Predictive Analytics [Athens, Greece], Centre d'investigation clinique de Toulouse (CIC 1436), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospitals Leuven [Leuven], Heidelberg University Hospital [Heidelberg], University of Milan, Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico [Milan, Italy], Leiden University Medical Center (LUMC), Radboud Institute for Molecular Life Sciences [Nijmegen, the Netherlands], Polish Mother’s Memorial Hospital Research Institute [Lodz] (ICZMP), Pediatric Nephrology [Barcelona, Spain] (Vall d’Hebron Hospital), Universitat Autònoma de Barcelona (UAB)-Vall d'Hebron University Hospital [Barcelona], Karolinska University Hospital [Stockholm], Karolinska Institutet [Stockholm], Geneva University Hospital (HUG), Aarhus University Hospital, Aarhus University [Aarhus], Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, ANTENATAL Consortium: An Hindryckx, Luc De Catte, Christophe Vayssieres, Agnès Sartor, Marion Groussolles, Christelle Plard, Paul Guerby, Laure Connan, Mathieu Morin, Elizabeth Simon, Jean Breaud, Anne-Hélène Saliou, Loic De Parscau, Nadine Jay, Isabelle Germouty, Gwenaelle Le Bouar, Amelie Ryckewaert, Marie-Christine Manca-Pellissier, Thierry Merrot, Helene Laurichesse, Denis Gallot, Lucie Bessenay, Laurent Bidat, Philippe Boize, Norbert Winer, Emma Allain-Launey, Claudine Le Vaillant, Fabienne Prieur, Marie-Pierre Lavocat, Frederic Coatleven, Eric Debromez, Jérôme Harembat, Brigitte Llanas, Romain Favre, Raphael Moog, Ariane Zaloszyc, Jérôme Massardier, Delphine Demede, Franck Perrotin, Sylvie Cloarec, Valérie Vequeau-Goua, Emmanuelle Descombes, Pierre Boulot, Denis Morin, Florent Fuchs, Julie Tenenbaum, Yves Ville, Thomas Blanc, Laurence Heidet, Anne Paris, Eric Dobremez, Marie-Françoise Froute, Jean Gondry, Charles Muszynski, Elodie Haraux, Fabienne Lobelle, Julien Chevreau, Jonathan Rosenblatt, Véronique Baudoin, Georges Deschenes, Virginie Guigue, Florence Amblard, Guylhène Bourdat-Michel, Elke Wühl, Franz Schaefer, Michael Elsässer, Nicola Persico, Federica Rossi, Gianantonio Manzoni, Erika A De Marco, Giovanni Montini, Valentina Capone, Leonardo Caforio, Antonio Zaccara, Michele Innocenzi, Pietro Bagolan, Nicola Capozza, Marco Castagnetti, Mariangela Mancini, Dick Oepkes, Phebe Adama van Scheltema, Wout Feitz, Barbara Kortmann, Michiel Schreuder, Marcin Tkaczyk, Małgorzata Stańczyk, Krzysztof Szaflik, Justyna Wojtera, Waldemar Krzeszowski, Tomasz Talar, Barbara Pawłowska, Katarzyna Fortecka-Piestrzeniewicz, Dariusz Olejniczak, Gema Ariceta, Silvia Arevalo, Carlota Rodo, Magdalena Fossum, Peter Lindgren, Paloma Parvex, Hassib Chehade., Schanstra, Joost, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Università degli Studi di Milano = University of Milan (UNIMI)

Subjects
Posterior urethral valve, medicine.medical_specialty, Urinary system, [SDV]Life Sciences [q-bio], kidney disease, prenatal biomarkers, Renal function, Prenatal care, 030204 cardiovascular system & hematology, DIAGNOSIS, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Medicine, obstructive uropathy, Obstructive uropathy, development, 030304 developmental biology, RISK, 0303 health sciences, Transplantation, Kidney, ddc:618, Science & Technology, business.industry, Obstetrics, Original Articles, prediction, Urology & Nephrology, Omics, medicine.disease, 6. Clean water, 3. Good health, [SDV] Life Sciences [q-bio], Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], medicine.anatomical_structure, Nephrology, embryonic structures, Settore MED/20, URINARY-TRACT OBSTRUCTION, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], business, Life Sciences & Biomedicine, Kidney disease
Abstract

Altres ajuts: The study is partially made possible by support of the 'Programme Hospitalier de Recherche Clinique and 'La Foundation de la Recherche Médicale (grant number DEQ20170336759, France). M.T. was supported by the Polish Mothers Memorial Hospital Research Institute (internal grant number 2016/IV/54-GW. LvdZ is supported by a Kolff grant from the Dutch Kidney Foundation (13OKJ36) and a ZonMW-VENI grant from the Netherlands Organisation for Scientific Research (91618036). This project has been supported by ERN ERKNet and ERN eUROGEN, which are partly co-funded by the European Union within the framework of the Third Health Programme 'ERN-2016-Framework Partnership Agreement 2017-2021'. Posterior urethral valves (PUV) account for 17% of paediatric end-stage renal disease. A major issue in the management of PUV is prenatal prediction of postnatal renal function. Fetal ultrasound and fetal urine biochemistry are currently employed for this prediction, but clearly lack precision. We previously developed a fetal urine peptide signature that predicted in utero with high precision postnatal renal function in fetuses with PUV. We describe here the objectives and design of the prospective international multicentre ANTENATAL (multicentre validation of a fetal urine peptidome-based classifier to predict postnatal renal function in posterior urethral valves) study, set up to validate this fetal urine peptide signature. Participants will be PUV pregnancies enrolled from 2017 to 2021 and followed up until 2023 in >30 European centres endorsed and supported by European reference networks for rare urological disorders (ERN eUROGEN) and rare kidney diseases (ERN ERKNet). The endpoint will be renal/patient survival at 2 years postnatally. Assuming α = 0.05, 1-β = 0.8 and a mean prevalence of severe renal outcome in PUV individuals of 0.35, 400 patients need to be enrolled to validate the previously reported sensitivity and specificity of the peptide signature. In this largest multicentre study of antenatally detected PUV, we anticipate bringing a novel tool to the clinic. Based on urinary peptides and potentially amended in the future with additional omics traits, this tool will be able to precisely quantify postnatal renal survival in PUV pregnancies. The main limitation of the employed approach is the need for specialized equipment. Accurate risk assessment in the prenatal period should strongly improve the management of fetuses with PUV.

Published
2020

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