525 results on '"Perrone, A. M."'
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2. Magneto-Thermal Instability In Galaxy Clusters II: Three-Dimensional Simulations
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Perrone, Lorenzo M. and Latter, Henrik
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Physics - Plasma Physics - Abstract
In the intracluster medium (ICM) of galaxies, exchanges of heat across magnetic field lines are strongly suppressed. This anisotropic heat conduction, in the presence of a large-scale temperature gradient, destabilizes the outskirts of galaxy clusters via the magneto-thermal instability (MTI), and thus supplies a source of observed ICM turbulence. In this paper we continue our investigation of the MTI with 3D simulations using the Boussinesq code SNOOPY. We redress two issues intrinsic to our previous 2D study: an inverse energy cascade and the impossibility of dynamo action. Contrary to 2D simulations, we find inconsequential transport of energy across scales (most energy is dissipated at the same scale as its injection), and that turbulent eddies are vertically elongated at or below the thermal conduction length, but relatively isotropic on larger scales. Similar to 2D, however, the saturated turbulent energy levels and the integral scale follow clear power-laws that depend on the thermal diffusivity, temperature gradient, and buoyancy frequency. We also show that the MTI amplifies magnetic fields, through a fluctuation dynamo, to equipartition strengths provided that the integral scale of MTI turbulence is larger than the viscous dissipation scale. Finally, we show that our scaling laws are consistent with extant observations of ICM turbulence if the thermal conductivity is reduced by a factor of $\sim 10$ from its Spitzer value, and that on global cluster scales the stable stratification significantly reduces the vertical elongation of MTI motions., Comment: 21 pages, 21 figure, submitted to MNRAS
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- 2021
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3. Magneto-Thermal Instability In Galaxy Clusters I: Theory and Two-Dimensional Simulations
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Perrone, Lorenzo M. and Latter, Henrik
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Physics - Plasma Physics - Abstract
Determining the origin of turbulence in galaxy clusters, and quantifying its transport of heat, is an outstanding problem, with implications for our understanding of their thermodynamic history and structure. As the dilute plasma of the intracluster medium (ICM) is magnetized, heat and momentum travel preferentially along magnetic field lines. This anisotropy triggers a class of buoyancy instabilities that destabilize the ICM, and whose turbulent motions can augment or impede heat transport. We focus on the magneto-thermal instability (MTI), which may be active in the periphery of galaxy clusters. We aim to take a fresh look at the problem and construct a general theory that explains the MTI saturation mechanism and provides scalings and estimates for the turbulent kinetic energy, magnetic energy, and heat flux. We simulate MTI turbulence with a Boussinesq code, SNOOPY, which, in contrast to previous work, allows us to perform an extensive sampling of the parameter space. In two dimensions the saturation mechanism involves an inverse cascade carrying kinetic energy from the short MTI injection scales to larger scales, where it is arrested by the stable entropy stratification; at a characteristic "buoyancy scale", the energy is dumped into large-scale g-modes, which subsequently dissipate. Consequently, the entropy stratification sets an upper limit on the size and strength of turbulent eddies. Meanwhile, the MTI conveys a substantial fraction of heat, despite the tangled geometry of the magnetic field. In a companion paper, these results are extended to three-dimensional flows, and compared to real cluster observations., Comment: 20 pages, 19 figures, submitted to MNRAS
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- 2021
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4. Clinical characteristics and survival outcome of early-stage, high-grade, serous tubo-ovarian carcinoma according to BRCA mutational status
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Marchetti, Claudia, Ataseven, Beyhan, Perrone, Anna M., Cassani, Chiara, Fruscio, Robert, Sassu, Carolina M., Apostol, Adriana I., Harter, Philipp, De Iaco, Pierandrea, Camnasio, Cristina Angela, Moubarak, Malak, Giannarelli, Diana, Scambia, Giovanni, and Fagotti, Anna
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- 2024
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5. Mapping the Relationship of White Matter Lesions to Depression in Multiple Sclerosis
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Baller, Erica B., Sweeney, Elizabeth M., Cieslak, Matthew, Robert-Fitzgerald, Timothy, Covitz, Sydney C., Martin, Melissa L., Schindler, Matthew K., Bar-Or, Amit, Elahi, Ameena, Larsen, Bart S., Manning, Abigail R., Markowitz, Clyde E., Perrone, Christopher M., Rautman, Victoria, Seitz, Madeleine M., Detre, John A., Fox, Michael D., Shinohara, Russell T., and Satterthwaite, Theodore D.
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- 2024
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6. Tuning humidity for highly selective detection of methanol and 2-butanone using MOF-derivatives NiO microrods
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Theodoro, Reinaldo S., Sá, Bruna S., Perrone, Olavo M., Perfecto, Tarcísio M., and Volanti, Diogo P.
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- 2023
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7. Unveiling oxygen vacancy impact on lizardite thermo and mechanical properties
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Pecinatto, H., Rêgo, Celso R. C., Wenzel, W., Frota, C. A., Perrone, B. M. S., Piotrowski, Maurício J., Guedes-Sobrinho, Diego, Dias, Alexandre C., Mota, Cicero, Gusmão, M. S. S., and Frota, H. O.
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- 2023
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8. Neutrino-electron magnetohydrodynamics in an expanding Universe
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Perrone, L. M., Gregori, G., Reville, B., Silva, L. O., and Bingham, R.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Phenomenology - Abstract
We derive a new model for neutrino-plasma interactions in an expanding universe that incorporates the collective effects of the neutrinos on the plasma constituents. We start from the kinetic description of a multi-species plasma in the flat Friedmann-Robertson-Walker metric, where the particles are coupled to neutrinos through the charged- and neutral-current forms of the weak interaction. We then derive the fluid equations and specialize our model to (a) the lepton epoch, where we consider a pair electron-positron plasma interacting with electron (anti-)neutrinos, and (b) after the electron-positron annihilation, where we model an electron-proton plasma and take the limit of slow ions and inertia-less electrons to obtain a set of neutrino-electron magnetohydrodynamics (NEMHD) equations. In both models, the dynamics of the plasma is affected by the neutrino motion through a ponderomotive force and, as a result, new terms appear in the induction equation that can act as a source for magnetic field generation in the early universe. A brief discussion on the possible applications of our model is proposed., Comment: 12 pages, 1 figure, submitted to Physical Review D; typos corrected, references added, added discussion on primordial magnetogenesis, accepted for publication in Physical Review D
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- 2021
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9. The International Trade Order and Development
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Perrone, Nicolás M., Buchanan, Ruth, book editor, Eslava, Luis, book editor, and Pahuja, Sundhya, book editor
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- 2023
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10. Four-dimensional drift-kinetic model for scrape-off layer plasmas
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Perrone, L. M., Jorge, R., and Ricci, P.
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Physics - Plasma Physics - Abstract
A four-dimensional plasma model able to describe the scrape-off layer region of tokamak devices at arbitrary collisionality is derived in the drift-reduced limit. The basis of the model is provided by a drift-kinetic equation that retains the full non-linear Coulomb collision operator and describes arbitrarily far from equilibrium distribution functions. By expanding the dependence of distribution function over the perpendicular velocity in a Laguerre polynomial basis and integrating over the perpendicular velocity, a set of four-dimensional moment equations for the expansion coefficients of the distribution function is obtained. The Coulomb collision operator, as well as Poisson's equation, are evaluated explicitly in terms of perpendicular velocity moments of the distribution function., Comment: 12 pages
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- 2020
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11. Imagining Alternatives? Latin American Scholarship on International Economic Law and the Global Economic Order
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Perrone, Nicolás M.
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international economics ,Latin American scholarship ,global economy - Abstract
This Article analyzes the role of Latin American international economic law scholarship within the global economic order. Many of the problems that Latin Americans face today relate to the global economy, such as labor conditions, access to medicine, and the use of natural resources, among others. The discussion of these problems, however, seldom recognizes the role of international economic law scholarship. Although the knowledge created by this scholarship may not completely explain why States actively behave in a certain way, it can serve to explain why they may refrain from certain actions. This Article argues that scholarship on international economic law plays a crucial role in the creation and reproduction of the current global economic order. If this claim is correct, regional scholarship can do more for Latin America than serving the advisory and litigation needs of States. By recognizing its role in constituting the global economic order, international economic law scholarship can promote alternative theories and practices that may help Latin America and its people find their place in the global economy.
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- 2020
12. Highly efficient detection of ethanol by SnO2 nanoparticles-decored NiO nanocuboids
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Perrone, Olavo M., Roveda, Antonio C., Jr, de Moraes, Daniel A., Theodoro, Reinaldo dos Santos, and Volanti, Diogo P.
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- 2023
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13. The enhanced n-butanol sensing performance of In2O3 loaded NiO cuboid heterostructure
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Perrone, Olavo M., Roveda, Antonio C., Jr, de Moraes, Daniel A., and Volanti, Diogo P.
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- 2023
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14. Linear Theory of Electron-Plasma Waves at Arbitrary Collisionality
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Jorge, R., Ricci, P., Brunner, S., Gamba, S., Konovets, V., Loureiro, N. F., Perrone, L. M., and Teixeira, N.
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Physics - Plasma Physics - Abstract
The dynamics of electron-plasma waves are described at arbitrary collisionality by considering the full Coulomb collision operator. The description is based on a Hermite-Laguerre decomposition of the velocity dependence of the electron distribution function. The damping rate, frequency, and eigenmode spectrum of electron-plasma waves are found as functions of the collision frequency and wavelength. A comparison is made between the collisionless Landau damping limit, the Lenard-Bernstein and Dougherty collision operators, and the electron-ion collision operator, finding large deviations in the damping rates and eigenmode spectra. A purely damped entropy mode, characteristic of a plasma where pitch-angle scattering effects are dominant with respect to collisionless effects, is shown to emerge numerically, and its dispersion relation is analytically derived. It is shown that such a mode is absent when simplified collision operators are used, and that like-particle collisions strongly influence the damping rate of the entropy mode., Comment: 23 pages, 10 figures, accepted for publication on Journal of Plasma Physics
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- 2018
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15. Impact of resilience, social support, and personality traits in patients with neuroinflammatory diseases during the COVID-19 pandemic
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Jakimovski, Dejan, Kavak, Katelyn S, Longbrake, Erin E., Levit, Elle, Perrone, Christopher M, Bar-Or, Amit, Benedict, Ralph HB, Riley, Claire S, De Jager, Philip L, Venkatesh, Shruthi, Walker, Elizabeth L.S., Xia, Zongqi, and Weinstock-Guttman, Bianca
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- 2022
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16. Cataclysmically disseminating neurologic presentation in an immunosuppressed lupus patient: From the National Multiple Sclerosis Society Case Conference Proceedings
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Perrone, Christopher M, Lisak, Robert P, Meltzer, Ethan I, Sguigna, Peter, Tizazu, Etsegenet, Jacobs, Dina, Melamed, Esther, Lucas, Ashlea, Freeman, Leorah, Pardo, Gabriel, Goodman, Andrew, Fox, Edward J, Costello, Kathleen, Parsons, Matthew S, Zamvil, Scott S, Frohman, Elliot M, and Frohman, Teresa C
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Biomedical and Clinical Sciences ,Clinical Sciences ,Diagnosis ,Differential ,Female ,Humans ,Immunocompromised Host ,Immunosuppression Therapy ,Lupus Erythematosus ,Systemic ,Middle Aged ,Varicella Zoster Virus Infection ,Neurosciences - Published
- 2019
17. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
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Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Davidson, Giana H, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Ford, Samuel, Garmanova, Tatiana, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gruendl, Magdalena, Halkias, Constantine, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jenkinson, Michael D, Jonker, Pascal, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn van der, Qureshi, Ahmad, Radenkovic, Dejan, Revell, Elliot J, Roberts, Keith, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Townend, Philip, Tsoulfas, Georgios, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, EuroSurg, NA, European Society of Coloproctology (ESCP), NA, Global Initiative for Children's Surgery, NA, GlobalSurg, NA, GlobalPaedSurg, NA, ItSURG, NA, PTSurg, NA, SpainSurg, NA, Italian Society of Colorectal Surgery, NA, Association of Surgeons in Training, NA, Irish Surgical Research Collaborative (ISRC), NA, Transatlantic Australasian Retroperitoneal Sarcoma Working, NA, Italian Society of Surgical Oncology, NA, Booth, Lesley, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Bahrami-Hessari, Mike, Riaz, Asad, Shah, Jaffer, Safi, Mohammed, Thereska, Dariel, Dajti, Irida, Cheddadi, Riadh, Tidjane, Anisse, Quinteros, Carlos A, khelfaoui, Ahmed, Salem, Khalifa M, Riffi, Omar, Kacimi, Salah Eddine O, Loudjedi, Salim, Damerdji, Tidjani, Pantoja Pachajoa, Diana A, Palacios Huatuco, René M, Alvarez, Fernando A, Doniquian, Alejandro M, Abeldaño Zuñiga, Roberto A, Schlottmann, Francisco, Cobos, Carlos M, Gigena, Cecilia, Forneris, Agustin Albani, Duro, Agustin, García-Mansilla, Agustín M, Busnelli, Virginia Cano, Poggi, Catalina, Mercado, Pedro L, González, Marcos, Castro Lalin, Agustina F, Mayer, Horacio F, Brandariz, Rodrigo, Slullitel, Pablo A, Boudou, Rocio, Lobos, Pablo A, Uffelmann, María C, Petersen, Maria L, Luzzi, Emilia, Padilla Lichtenberger, Fernando L, Crespi Amor, María S, Zarratea, Celeste S, Esteves, Tomas A, Gemelli, Nicolas A, Tirapegui, Sebastián, Liyo, Juan, Scherñuk, Jordán, Boccalatte, Luis A, Balmaceda, Ruben D, D'Addino, Jose L, Caubet, María M, Calderón Arancibia, José A, Chwat, Carina, Morris, Brian, Avellaneda, Nicolas, Pedraza Salazar, Ivana I, Eskinazi, Diego G, Vargas, Lara, Muriel, María E, Lucchini, Sergio M, Gosselink, Martijn P, Davis, Amelia L, Barker, John C, Qin, Kirby R, Proud, David M, Cox, Daniel RA, Goh, Su Kah, Liu, David S, Wu, Damien M, Merrett, Neil D, Badiani, Sarit S, Sengupta, Shomik, Jain, Anshini, Steen, Christopher J, Wong, Enoch, Ip, Christopher CK, Leaning, Matthew G, McCartney, Conor B, Gananadha, Sivakumar, Yeap, Evie FW, Stevens, Sean G, Vu, Anh N, Martin, Sarah A, Stanley, Guy H M, Watson, David I, Townend, Philip J, Young, Thomas K, Cox, Georgia T, Dawson, Amanda C, Laura, Sharon E, Lun, Elizabeth W Y, Liang, Ina X, O'Neill, Christine J, Lott, Natalie J, Chuan, Alwin, Saravanan, SK, Gundara, Justin, Ong, Bee Shan, Nataraja, Ramesh M, Pacilli, Maurizio, Foley, Daniel M, Ooi, Geraldine J, Traeger, Luke, MacDermid, Ewan, Daruwalla, Jurstine, Hodgson, Russell, Heriot, Alexander G, Mulligan, Christopher S, Blefari, Nicholas D A, Purcell, Shaun S, Frankel, Adam J, Guerra, Glen R, Tefay, Joan S, Liang, Rhea W Y, Kroon, Hidde M, Farfus, Anthony W, Warren, Leigh R, Roy, Jennifer M, Whitfield, Robert J, Moller, Cea-Cea B, Davis, Sean S, Sammour, Tarik, Lam, Yick Ho, Kour, Kevin, Gan, Siang Wei, Coventry, Brendon J, Dawson, Joseph A, Batstone, Martin D, King, Sebastian K, Scott, Nathan J, Foo, Jonathan W, Shepherd, Talia, Page, Richard S, Choong, Peter F, Badgery, Henry E, Chong, Lynn, Taylor, Lillian, Hii, Michael W, Wright, Gavin M, Kong, Joseph CH, Watson, Matthew M, Bock, Jacob, Lidder, Surjit S, Elias, Patrick, Kanavathy, Sathisvaran, Koh, Cherry E, Chennakesavan, Srinivas Kondalsamy, Panuganti, Vishwakar, Latif, Haider, Yeung, Justin MC, Besson, Alex J, Tse, Eunice Q Y, Pitcher, Meron E, Taylor, Danielle L, Nahm, Christopher B, Lim, Alicia, Tree, Kevin, Aigner, Felix, Dawoud, Christopher, Foessleitner, Philipp, Zimmermann, Matthias, Wiedemann, Dominik, Findl, Oliver, Messner, Franka, Bauer, Marlies, Nägele, Felix, Kronberger, Irmgard E, Öfner, Dietmar, Härter, Bettina, Bicz, Nina Ru B, Zwittag, Paul M, Poier, Nikolaus, Navarro, Francisco Ruiz, Zebuhr, Yorck A, Köglberger, Paul, Wiesinger, Clemens G, Mathew, Erwin, Trivik-Barrientos, Felipe, Königsrainer, Ingmar, Djedovic, Gabriel, Cohnert, Tina U, Lumenta, David B, Singer, Georg, Leithner, Andreas, Kamolz, Lars-Peter, Andrianakis, Alexandros, Puchwein, Paul, Mikalauskas, Saulius, Kirchweger, Patrick, Függer, Reinhold, Mittermair, Christof, Russe, Elisabeth, Paal, Peter, Grünbart, Martin, de Cillia, Michael, Weiss, Helmut G, Steiner, Florian, Binder, Alf Dorian, Samadov, Elgun, Ibrahimli, Arturan, Muslumov, Gurbankhan, Bayramov, Nuru Y, Saunders, Jada M, Almoosa, Noora, Haj-Ibrahim, Huzifa, Maresch, Martin, Ezzdean, Weaam K, Juma, Isam M, Hasan, Layla H, Haider, Fayza HA, Alfaqawi, Ghassan Salman, Alam, Mohammed S, Islam, Shahnoor, Basher, AKM K, Mitul, Ashrarur Rahman, Islam, Nazmul, Oosterkamp, Antje E, Ahmed, Tanveer, Hannan, M Jafrul, Padmore, Greg M, Doyle, Alex F, LaCorbiniere, Karisha L, Boyce, Rico D R, Ragoobar, Paul T, Walkes, Keisha M Y, Haynes, Amelia A, Corbin, Sasha M, Litvina, Yauheniya A, Makhmudov, Anvar, Strypstein, Sébastien, Dhondt, Bert, Rasschaert, Ricky, Farid, Yasser, Wahib, El Mahdi, Pigeolet, Manon, Belle, Koen Van, De Wachter, Stefan, Komen, Niels, Vandeputte, Mathieu PJ, Jansen, Yanina JL, Stijns, Jasper, Eynde, Jef Van den, Olowo, Benedicte I, Feraudy, Israel C, Dragisic, Vedran, Martinovic, Vlatka, Barišić, Tatjana, Penava, Nikolina, Hudic, Igor, Delibegovic, Samir, Bogdanović, Gordana, Grgić, Gordana, Cerovac, Anis, Cerovac, Elmedina, Bedada, Alemayehu G, Baiocchi, Glauco, Wainstein, Alberto, Moisés, Elaine Christine D, Zani, Ana Carolina Tagliatti, de Campos Prado, Caio Antonio, Panis, Carolina, Rech, Daniel, Soares da Silva, Ruan Gabriel, Joviliano, Edwaldo E, Rezende, Ricardo F, Reis, Igor G N, Pires, Robinson E S, Christiano, Adriana Borgonovi, Consani, Heitor F X, Pugliesi, Felipe G, Takeda, Flavio R, Mariani, Alessandro W, Valadares, Ricardo J B, Andreollo, Nelson A, Lopes, Luiz Roberto, Tonello, Cristiano, Alonso, Nivaldo, dos Santos, Carlos Ferreira, Lima, Leonardo S, Salgado, Wilson, Pereira, Thiago H S, Gatti, Arthur Paredes, Oliva, Ramon N L, Nardi, Caroline N, Sousa, Alvaro F L, Ribeiro, Ivonizete P, Carvalho, Herica E F, Oliveira, Layze B, Schneider, Guilherme, Casteleins, William Augusto, Silva, Larissa M, Gomes, Carlos Augusto, da Cunha Viana Júnior, Alonço, Cruz, Ricardo P, Gomes, Gustavo MA, Buarque, Igor L, Barros, Aldo V, Marangon, Gustavo B, Flumignan, Ronald LG, Nakano, Luís CU, Pascoal, Patrícia IF, Santos, Brena C, Kuramoto, Danielle AB, Correia, Rebeca M, Amaral, Fabio CF, Flumignan, Carolina DQ, Dussán-Sarria, Jairo A, Simões, Romeo L, Amorim, Robson L, Silva, Jeancarllo S, Lyra Junior, Humberto F, Julio, Nathalia S, Gerber, Marlus T, dos Santos, José Mauro, de Oliveira, Joao Carlos C, Palamim, Camila VC, Marson, Fernando AL, Gomes, Iolanda M, Oliveira, Priscila R, Lima, Ana Lucia L M, Carvalho, Vladimir C, Silva, Jorge S, NA, Ulysses Ribeiro, Laporte, Gustavo Andreazza, Gonçalves, Mateus Capuzzo, Botacin, Lais S, Avelino, Melissa AG, Brito, Luiz Gustavo O, Hristova, Evguenia T, Stoyanov, Vladislav Valentinov, Sakakushev, Boris E, Dardanov, Dragomir D, Sokolov, Manol B, Mehta, Ananya, Gyokova, Elitsa H, Abdullahi, Mohamed, Karamanliev, Martin P, Dimitrov, Dobromir D, Slavchev, Mihail T, Atanasov, Boyko Ch, Yotsov, Tsanko I, Hadzhiev, Dimitar Bozhidarov, Stock, Simon E, Nwegbu, Chukwuemeka Gerald, Tanyi, Tanyi John, Brown, James A, Arneja, Jugpal S, Lee, Susan M, Kancherla, Ramya, Kidane, Biniam, Champagne, Pierre-Olivier, Ma, Xiya, Munro, Allana, McKeen, Dolores M, Glinka, Juan, Vasarhelyi, Edward M, Subramani, Yamini, Alfaro, Hilda, Shah, Ushma J, Gonzalez, Nelson J, MacNeil, S Danielle, Nagappa, Mahesh, Malthaner, Richard A, Brackstone, Muriel, Alkhamesi, Nawar A, Qiabi, Mehdi, Arango-Ferreira, Camila, Prempeh, Agya B A, Dumitra, Sinziana, Spence, Richard T, Bedard, Eric LR, Luc, Jessica GY, Johnston, Brian R, Attabib, Najmedden, Persad, Amit RL, Das, Sunit, Khoshbin, Amir, Ladha, Karim S, Sankar, Ashwin, Teja, Bijan, Daza, Julian F, Chan, Veronica F, Baertschiger, Reto M, Zani, Augusto, Nessim, Carolyn, McIsaac, Daniel I, Singh, Mandeep, Behzadi, Abdollah, Dell, Angela J, Al Riyami, Salim M, Dajani, Khaled Z, Bigam, David, Manikala, Vinod K, Street, John T, Mayson, Kelly V, Wallis, Christopher J D, Mimica, Ximena, Villanueva, Julio, Altamirano, Roberto, Waissbluth, Sofia, Marín, Diego I, Fonseca, Bruno Catoia, Hodali, Andrés J, Ramos, Andrea I, Valenzuela, Marco A, Torres, Janina J, Song, Yi, Yang, Wah, Aldanakh, Abdullah, Alradhi, Mohammed, Lyu, Yidong, Chen, Yan, Fletcher, Angélica V, Camargo, Daniela, Casanova, Rafael Figueroa, Medina, Camilo Andres Caicedo, Bolivar, Dinimo, Garcia, Tatiana 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Joseph, Donnelly, Liam J, Erridge, Simon, Chidambaram, Swathikan, Luo, Xun, Bansal, Sujesh, Ryan, Neil AJ, Smith, Alexander C D, Flatman, Michael, Wafaie, Imad, Malik, Muhammad Isfandyar Khan, Thumbadoo, Ruben P, Hussain, Shoaib F, Henein, Christin, Hamad, Yousif T, Belgaumkar, Ajay P, Bosanquet, David C, Kolias, Angelos G, Choi, David, Marcus, Hani J, Horsfall, Hugo RM Layard, Khan, Danyal Z, Sahni, Arun, Millward, Christopher P, Render, Luke, Truss, Adam, Elmoslemany, Tarek, Parmar, Chetan, Hanger, Joseph, Sheen, Jonathon, Rait, Jaideep S, Foreman, Jennifer, Marzouqa, Natalie, Fontalis, Andreas, Voulalas, Grigorios, CHEONG, Ryan Chin Taw, Dindyal, Sanjay, Arumugam, Sathyaseelan, Ward, Thomas R W, Stephens, Alastair S, Douka, Eleftheria, Abou-Foul, Ahmad K, McKay, Siobhan C, Kitchen, Mark O, Rees-Stoner, Oliver DJ, Balasubramanya, Supriya, Akhtar, Muhammad Adeel, Warwick, Andrew J, Pawar, Shweta, Dubey, Vivek, Al-Yaseen, Mustafa W, Williams, Christopher YK, Laird, Alexander, Krishna, Kandaswamy, Anyaugo, Ngozi S, Wuraola, Obafemi K, Odejinmi, Funlayo, Craven, Joanna M, West, Charlotte L, Barter, Reece A, Navaratnam, Devaraj M, Malik, Shahbaz S, Mahendran, Vimaladhithan, Zilvetti, Miguel, Lovegrove, Richard E, Board, Tim N, Zeiton, Moez, Sarwar, Safdar A, Duff, Sarah E, Hsabo, Elmuiz A, Nugur, Ashwani Kumar, Morris, Richard M, Lala, Anil K, Kwan-Feinberg, Rita O, Ross, Samuel W, Dressler, Jeremy A, Evans, Faye M, Wason, Shaun E L, Vogel, Keianna R, Wang, Joanna C, Sulciner, Megan L, Hirji, Sameer, Raoof, Mustafa, Wolff, Christopher J, kent, Ilan, Turan, Alparslan, Teixeira, Pedro G, Olson, Kristofor A, Patel, Neil D, Krishnamoorthy, Vijay, Moris, Dimitrios, Rice, Henry E, Gabr, Hesham, Satoskar, Savni R, Castater, Christine A, Jmaileh, Manal, Payne, Rachel E, Kwon, David S, Aarabi, Shahram, Escobar, Pedro F, Kronenfeld, Joshua P, Dalton, Michael K, Etchill, Eric W, Haut, Elliott R, Vervoort, Dominique, Dehal, Ahmed, McKenney, Mark, Elkbuli, Adel, Gosain, Ankush, Abdelsattar, Zaid M, Naunheim, Matthew R, Burks, Ciersten A, Zhou, Allen S, Heng, Marilyn, Abohashem, Shady, Lozano-Calderón, Santiago A, Reisenauer, Janani S, Mouawad, Nicolas J, Diehl, Thomas M, Eriksson, Evert A, Marwaha, Jayson S, Schroeppel, Thomas J, LaRocca, Christopher J, Chang, Grace H, Hassan, Romana, Nosanov, Lauren B, Rickard, Jennifer L, Avraham, Jacob B, Petrone, Patrizio, Sferra, Joseph J, Hadaya, Joseph, Mead, Brittany S, Hauptman, Jason S, Ahmad, Maleeha, Meola, Antonio, Chang, Steven D, Ko, Ara, Specht, Katherine E, Choudhry, Asad, Encalada, Ronald Zerna, Poggio, Juan L, Xing, Hang, Glass, Nina E, Hooker, Robert, Martins, Paulo N, Scott, Erin M, Bankhead, Brittany K, Giorgakis, Emmanouil, Nigh, Joe, Osborn, Tamara, Tay Lasso, Erika L, Beswick, Daniel M, Berndtson, Allison E, Kaups, Krista L, Chen, Lee-lynn, Farrell, Michael S, Boeck, Marissa A, Vaysburg, Dennis M, Kassam, Al-Faraaz, Turner, Kevin M, Dyas, Adam R, Coleman, Julia R, Folsom, Megan, Lam, Christopher M, Kumer, Sean C, Larson, Kelsey, Turner, Scott, Guidry, Christopher, Reddy, Madhuri, Berbel, German, Findley, Austin, Beahm, David, Bur, Andres, Marlor, Derek, Houndschell, Corey, Carver, Shea, Ulrich, Alissa, Bhutiani, Neal, DiChiacchio, Laura, Abdou, Hossam, Napolitano, Lena M, Ghebre, Rahel, Bass, Gary Alan, Kaplan, Lewis J, Martin, Niels D, Duffy, Caoimhe C, Abdelhamid, Sultan S, Daley, Brian J, Roland, Christina L, Dumas, Ryan P, Ban, Vin Shen, Rajesh, Aashish, Davies, Mark G, Purudappa, Prabhudev P, Walters, Camila B, Lin, Nicole, Ruzgar, Nensi M, Ullrich, Sarah J, Trostchansky, Ivan, Bonilla-Cal, Fernando, Castedo, Fabiola, Sobrero, Helena, Acuña, Gastón, Álvarez, Sofía M, Tarigo, Josefina, Carbajal, Ana C, Carbajal, Ana, Reyes, Antonio R, Al-Eryani, Fatima A, Alqousi, Nardeen N, Alattas, Zainab, Al-Saban, Rafat A, Al-Shehari, Mohammed M, ALHammadi, Nawal T, Shream, Sarah A, Al-Naggar, Hamza M, Al-Qalisi, Lina M, Nadeesh, Areej E, Al-Samawi, Hytham H, Bajjah, Hadeel M, AL-Ameri, Saba A, Albably, Jamal F, Ghannam, Rana A, Shamsan, Amatallah H, Meead, Abdullah A, Al- Zubaidi, Riham Q, Zulait, Mohammed A, Najeeb, Halah, Alsayadi, Musaed M, Al-Mashreqi, Seham K, Al-Jomai, Najla A, Alsayadi, Ramzi A, Al-Naggar, Moath M, Almarashi, Hassan A, Musaeed, Hasna M, Al-Raimi, Ibrahim M, Ghanem, Hossam N, Al-Zazay, Karim A, AL-Mahdi, Shehab A, Almontaser, Amatalaleem S, Savopoulos, Vanessa A S, Munthali, James, Kabongo, Kizito M C, Mushiwokufa, Willard, Ngulube, Allan, Ntoto, Crispin, Magama, Praise T, Dzinotyiwei, Daniel, Chivanga, Shelton K, Dube, Ngqabutho S, Sanchez, Ernesto C, Moyo, Assel T, Chengahomwe, Antony, Chinyowa, Simbarashe, Siamuchembu, Maphios, Bondera, Tafadzwa, and Mushawarima, Trust
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- 2022
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18. Unraveling the functional attributes of the language connectome: crucial subnetworks, flexibility and variability
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Roger, E., Rodrigues De Almeida, L., Loevenbruck, H., Perrone-Bertolotti, M., Cousin, E., Schwartz, J.L., Perrier, P., Dohen, M., Vilain, A., Baraduc, P., Achard, S., and Baciu, M.
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- 2022
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19. Cesarean scar pregnancy: a practical overview and our series of combined double step procedure management.
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DAMIANI, Gianluca R., VIMERCATI, Antonella, DI GENNARO, Daniele, VITAGLIANO, Amerigo, GIAMPAOLINO, Pierluigi, MALVASI, Antonio, PERRONE, Anna M., PELLEGRINO, Antonio, DELLINO, Miriam, and CICINELLI, Ettore
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MEDICAL sciences ,ABORTION ,PREGNANT women ,HEALTH facilities ,ECTOPIC pregnancy ,PREGNANCY complications ,UTERINE rupture - Published
- 2024
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20. Taking Local Expectations Seriously: A Fresh Start for Foreign Investment Governance?
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Perrone, Nicolás M., Bungenberg, Marc, Series Editor, Krajewski, Markus, Series Editor, Tams, Christian J., Series Editor, Terhechte, Jörg Philipp, Series Editor, Ziegler, Andreas R., Series Editor, Crämer, Judith, Assistant Editor, von Bogdandy, Armin, Advisory Editor, Cottier, Thomas, Advisory Editor, Griller, Stefan, Advisory Editor, Hatje, Armin, Advisory Editor, Herrmann, Christoph, Advisory Editor, Hilf, Meinhard, Advisory Editor, Kovacic, William E., Advisory Editor, Marceau, Gabrielle, Advisory Editor, Petersmann, Ernst-Ulrich, Advisory Editor, Ruiz Fabri, Hélène, Advisory Editor, Simma, Bruno, Advisory Editor, Streinz, Rudolf, Advisory Editor, Haskell, John D., editor, and Rasulov, Akbar, editor
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- 2020
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21. Fertility-sparing treatment in advanced-stage serous borderline ovarian tumors. An analysis from the MITO14 study database
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Falcone, Francesca, Breda, Enrico, Ferrandina, Gabriella, Malzoni, Mario, Perrone, Anna M., Cormio, Gennaro, Di Donato, Violante, Frigerio, Luigi, Mangili, Giorgia, Raspagliesi, Francesco, Festi, Anna, Scibilia, Giuseppe, Biglia, Nicoletta, Sorio, Roberto, Vizza, Enrico, Losito, Nunzia S., and Greggi, Stefano
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- 2021
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22. COVID-19 free oncologic surgical hub: The experience of reallocation of a gynecologic oncology unit during pandemic outbreak
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Perrone, Anna M., Dondi, Giulia, Giunchi, Susanna, De Crescenzo, Eugenia, Boussedra, Safia, Tesei, Marco, D'Andrea, Rocco, De Leo, Antonio, Zamagni, Claudio, Morganti, Alessio G., De Palma, Alessandra, and De Iaco, Pierandrea
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- 2021
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23. Clinical characteristics and survival outcome of early-stage, high-grade, serous tubo-ovarian carcinoma according to BRCA mutational status
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Marchetti, C, Ataseven, B, Perrone, A, Cassani, C, Fruscio, R, Sassu, C, Apostol, A, Harter, P, De Iaco, P, Camnasio, C, Moubarak, M, Giannarelli, D, Scambia, G, Fagotti, A, Marchetti C., Ataseven B., Perrone A. M., Cassani C., Fruscio R., Sassu C. M., Apostol A. I., Harter P., De Iaco P., Camnasio C. A., Moubarak M., Giannarelli D., Scambia G., Fagotti A., Marchetti, C, Ataseven, B, Perrone, A, Cassani, C, Fruscio, R, Sassu, C, Apostol, A, Harter, P, De Iaco, P, Camnasio, C, Moubarak, M, Giannarelli, D, Scambia, G, Fagotti, A, Marchetti C., Ataseven B., Perrone A. M., Cassani C., Fruscio R., Sassu C. M., Apostol A. I., Harter P., De Iaco P., Camnasio C. A., Moubarak M., Giannarelli D., Scambia G., and Fagotti A.
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Objective: To investigate the role of BRCA1/2 mutations in early ovarian cancer (eOC) (International Federation of Gynecology and Obstetrics FIGO 2014 stage I-II), and its impact on prognosis after relapse. Methods: In this multicenter retrospective study, clinical and survival data from high-grade serous (HGS)-eOC patients at presentation and recurrence were compared according to BRCA status: BRCA-mutated (BRCAmut) vs. BRCA wild-type (BRCAwt). Results: Among 191 HGS-eOC patients, 89 were BRCAmut and 102 BRCAwt. There was no significant difference according to the BRCA status in terms of Progression-Free Survival (PFS). A longer Overall Survival (OS) was found in BRCAmut patients. Stage I patients had significantly improved PFS vs stage II, regardless of BRCA status. At multivariate analysis, stage at diagnosis was the only variable with a significant effect on PFS. No factors were significantly relevant on OS, albeit younger age and BRCA mutation showed a slight impact. Post-Recurrence Survival (PRS) in the BRCAmut population was significantly improved compared with BRCAwt. At multivariate analysis, Secondary Cytoreductive Surgery was the strongest predictor for longer PRS, followed by PARPi maintenance at recurrence. Conclusions: BRCA-status is not a prognostic factor in early ovarian cancer regarding PFS. However, our data suggest a better prognosis after relapse in BRCAm population.
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- 2024
24. Diagnosis and management of isolated serous tubal intraepithelial carcinoma: A qualitative focus group study
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Negri, S, Fisch, C, de Hullu, J, van Bommel, M, Simons, M, Bogaerts, J, Apperloo, M, Baiocchi, G, Bakker, J, Bart, J, van Beekhuizen, H, Bernardini, M, Boere, I, Bulten, J, Chen, L, Chrzan, A, Dorum, A, Ewing-Graham, P, Ferrero, A, Floter Radestad, A, Fruscio, R, Gaarenstroom, K, Garcia, C, Harter, P, Hoogstad-van Evert, J, de Iaco, P, Klooster, A, Kooreman, L, Jacobsen, M, Kruse, A, Kwon, J, Lawson, B, Lax, S, van Lonkhuijzen, L, Lu, K, Manchanda, R, Marchetti, C, Mccluggage, W, Mcnally, O, Mourits, M, Nicum, S, Norquist, B, Perrone, A, Piek, J, Polastro, L, Polee, M, Rabban, J, Reesink, N, de los Reyes Oliver Perez, M, Roes, E, Rychlik, A, Shih, I, Soong, T, Speiser, P, Stone, R, Tamussino, K, Tognon, G, Tuninetti, V, Valabrega, G, Vos, M, Welz, J, Zizioli, V, Hermens, R, Steenbeek, M, Negri S., Fisch C., de Hullu J. A., van Bommel M., Simons M., Bogaerts J., Apperloo M. J. A., Baiocchi G., Bakker J. L., Bart J., van Beekhuizen H. J., Bernardini M. Q., Boere I., Bulten J., Chen L. -M., Chrzan A., Dorum A., Ewing-Graham P. C., Ferrero A., Floter Radestad A., Fruscio R., Gaarenstroom K. N., Garcia C., Harter P., Hoogstad-van Evert J. S., de Iaco P., Klooster A., Kooreman L. F. S., Jacobsen M., Kruse A. -J., Kwon J. S., Lawson B. C., Lax S. F., van Lonkhuijzen L. R. C. W., Lu K. H., Manchanda R., Marchetti C., McCluggage W. G., McNally O. M., Mourits M. J. E., Nicum S., Norquist B. M., Perrone A. M., Piek J. M. J., Polastro L., Polee M. B., Rabban J. T., Reesink N., de los Reyes Oliver Perez M., Roes E. -M., Rychlik A., Shih I. -M., Soong T. R., Speiser P., Stone R. L., Tamussino K., Tognon G., Tuninetti V., Valabrega G., Vos M. C., Welz J., Zizioli V., Hermens R. P. M. G., Steenbeek M. P., Negri, S, Fisch, C, de Hullu, J, van Bommel, M, Simons, M, Bogaerts, J, Apperloo, M, Baiocchi, G, Bakker, J, Bart, J, van Beekhuizen, H, Bernardini, M, Boere, I, Bulten, J, Chen, L, Chrzan, A, Dorum, A, Ewing-Graham, P, Ferrero, A, Floter Radestad, A, Fruscio, R, Gaarenstroom, K, Garcia, C, Harter, P, Hoogstad-van Evert, J, de Iaco, P, Klooster, A, Kooreman, L, Jacobsen, M, Kruse, A, Kwon, J, Lawson, B, Lax, S, van Lonkhuijzen, L, Lu, K, Manchanda, R, Marchetti, C, Mccluggage, W, Mcnally, O, Mourits, M, Nicum, S, Norquist, B, Perrone, A, Piek, J, Polastro, L, Polee, M, Rabban, J, Reesink, N, de los Reyes Oliver Perez, M, Roes, E, Rychlik, A, Shih, I, Soong, T, Speiser, P, Stone, R, Tamussino, K, Tognon, G, Tuninetti, V, Valabrega, G, Vos, M, Welz, J, Zizioli, V, Hermens, R, Steenbeek, M, Negri S., Fisch C., de Hullu J. A., van Bommel M., Simons M., Bogaerts J., Apperloo M. J. A., Baiocchi G., Bakker J. L., Bart J., van Beekhuizen H. J., Bernardini M. Q., Boere I., Bulten J., Chen L. -M., Chrzan A., Dorum A., Ewing-Graham P. C., Ferrero A., Floter Radestad A., Fruscio R., Gaarenstroom K. N., Garcia C., Harter P., Hoogstad-van Evert J. S., de Iaco P., Klooster A., Kooreman L. F. S., Jacobsen M., Kruse A. -J., Kwon J. S., Lawson B. C., Lax S. F., van Lonkhuijzen L. R. C. W., Lu K. H., Manchanda R., Marchetti C., McCluggage W. G., McNally O. M., Mourits M. J. E., Nicum S., Norquist B. M., Perrone A. M., Piek J. M. J., Polastro L., Polee M. B., Rabban J. T., Reesink N., de los Reyes Oliver Perez M., Roes E. -M., Rychlik A., Shih I. -M., Soong T. R., Speiser P., Stone R. L., Tamussino K., Tognon G., Tuninetti V., Valabrega G., Vos M. C., Welz J., Zizioli V., Hermens R. P. M. G., and Steenbeek M. P.
- Abstract
Objective: A Serous Tubal Intraepithelial Carcinoma (STIC) without concomitant invasive carcinoma is occasionally identified and associated with a high risk of subsequent peritoneal carcinomatosis. Management needs optimisation. This study explores professionals' opinions and clinical practices regarding the diagnosis, counselling, treatment and follow-up of isolated STIC to facilitate clinical decision making and optimise the direction of future research. A secondary aim is to assess international clinical guidelines. Design: Focus group study. Setting: Four online sessions. Population: International panel (n = 12 countries) of gynaecologists, gynaecologic oncologists, pathologists and medical oncologists (n = 49). Methods: A semi-structured interview guide was used. Two independent researchers analysed transcripts by open and axial coding. Results were organised in domains. Relevant (inter)national guidelines were screened for recommendations regarding isolated STIC. Main Outcome Measures: Professionals' opinions and clinical practices regarding isolated STIC management. Results: Regarding pathology, most professionals identified the SEE-FIM protocol as standard of care for high-risk patients, whereas variation exists in the histopathological examination of fallopian tubes in the general population. Confirmation of STIC diagnosis by a specialised pathologist was recommended. Regarding work-up and follow-up after STIC diagnosis, there was variety and discordance. Data on outcomes is limited. As for treatment, chemotherapy and PARP inhibitors were not recommended by most. Eleven guidelines provided limited recommendations. Conclusions: We identified recommendations and highlighted knowledge gaps in the diagnosis and management of isolated STIC. Moreover, recommendations in clinical guidelines are limited. There is an agreed need for international collaboration for the prospective registration of isolated STIC.
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- 2024
25. SENECA study: staging endometrial cancer based on molecular classification
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Chacon, E, Boria, F, Lyer, R, Fanfani, F, Malzoni, M, Bretova, P, Luzarraga Aznar, A, Fruscio, R, Jedryka, M, Toth, R, Perrone, A, Kakkos, A, Cristobal Quevedo, I, Congedo, L, Zanagnolo, V, Fernandez-Gonzalez, S, Ferro, B, Narducci, F, Hovhannisyan, T, Aksahin, E, Cardenas, L, Oliver, M, Nozaleda, G, Arnaez, M, Misiek, M, Ferrero, A, Pain, F, Zarragoitia, J, Diaz, C, Ceppi, L, Mehdiyev, S, Roldan-Rivas, F, Guijarro-Campillo, A, Amengual, J, Manzour, N, Sanchez Lorenzo, L, Nunez-Cordoba, J, Gonzalez Martin, A, Minguez, J, Chiva, L, Chacon E., Boria F., Lyer R. R., Fanfani F., Malzoni M., Bretova P., Luzarraga Aznar A., Fruscio R., Jedryka M. A., Toth R., Perrone A. M., Kakkos A., Cristobal Quevedo I., Congedo L., Zanagnolo V., Fernandez-Gonzalez S., Ferro B., Narducci F., Hovhannisyan T., Aksahin E., Cardenas L., Oliver M. R., Nozaleda G., Arnaez M., Misiek M., Ferrero A., Pain F. A., Zarragoitia J., Diaz C., Ceppi L., Mehdiyev S., Roldan-Rivas F., Guijarro-Campillo A. R., Amengual J., Manzour N., Sanchez Lorenzo L., Nunez-Cordoba J. M., Gonzalez Martin A., Minguez J. A., Chiva L., Chacon, E, Boria, F, Lyer, R, Fanfani, F, Malzoni, M, Bretova, P, Luzarraga Aznar, A, Fruscio, R, Jedryka, M, Toth, R, Perrone, A, Kakkos, A, Cristobal Quevedo, I, Congedo, L, Zanagnolo, V, Fernandez-Gonzalez, S, Ferro, B, Narducci, F, Hovhannisyan, T, Aksahin, E, Cardenas, L, Oliver, M, Nozaleda, G, Arnaez, M, Misiek, M, Ferrero, A, Pain, F, Zarragoitia, J, Diaz, C, Ceppi, L, Mehdiyev, S, Roldan-Rivas, F, Guijarro-Campillo, A, Amengual, J, Manzour, N, Sanchez Lorenzo, L, Nunez-Cordoba, J, Gonzalez Martin, A, Minguez, J, Chiva, L, Chacon E., Boria F., Lyer R. R., Fanfani F., Malzoni M., Bretova P., Luzarraga Aznar A., Fruscio R., Jedryka M. A., Toth R., Perrone A. M., Kakkos A., Cristobal Quevedo I., Congedo L., Zanagnolo V., Fernandez-Gonzalez S., Ferro B., Narducci F., Hovhannisyan T., Aksahin E., Cardenas L., Oliver M. R., Nozaleda G., Arnaez M., Misiek M., Ferrero A., Pain F. A., Zarragoitia J., Diaz C., Ceppi L., Mehdiyev S., Roldan-Rivas F., Guijarro-Campillo A. R., Amengual J., Manzour N., Sanchez Lorenzo L., Nunez-Cordoba J. M., Gonzalez Martin A., Minguez J. A., and Chiva L.
- Abstract
OBJECTIVE: Management of endometrial cancer is advancing, with accurate staging crucial for guiding treatment decisions. Understanding sentinel lymph node (SLN) involvement rates across molecular subgroups is essential. To evaluate SLN involvement in early-stage (International Federation of Gynecology and Obstetrics 2009 I-II) endometrial cancer, considering molecular subtypes and new European Society of Gynaecological Oncology (ESGO) risk classification. METHODS: The SENECA study retrospectively reviewed data from 2139 women with stage I-II endometrial cancer across 66 centers in 16 countries. Patients underwent surgery with SLN assessment following ESGO guidelines between January 2021 and December 2022. Molecular analysis was performed on pre-operative biopsies or hysterectomy specimens. RESULTS: Among the 2139 patients, the molecular subgroups were as follows: 272 (12.7%) p53 abnormal (p53abn, 1191 (55.7%) non-specific molecular profile (NSMP), 581 (27.2%) mismatch repair deficient (MMRd), 95 (4.4%) POLE mutated (POLE-mut). Tracer diffusion was detected in, at least one side, in 97.2% of the cases; with a bilateral diffusion observed in 82.7% of the cases. By ultrastaging (90.7% of the cases) or one-step nucleic acid amplification (198 (9.3%) of the cases), 205 patients were identified with affected sentinel lymph nodes, representing 9.6% of the sample. Of these, 139 (67.8%) had low-volume metastases (including micrometastases, 42.9%; and isolated tumor cells, 24.9%) while 66 (32.2%) had macrometastases. Significant differences in SLN involvement were observed between molecular subtypes, with p53abn and MMRd groups having the highest rates (12.50% and 12.40%, respectively) compared with NSMP (7.80%) and POLE-mut (6.30%), (p=0.004); (p53abn, OR=1.69 (95% CI 1.11 to 2.56), p=0.014; MMRd, OR=1.67 (95% CI 1.21 to 2.31), p=0.002). Differences were also noted among ESGO risk groups (2.84% for low-risk patients, 6.62% for intermediate-risk patients, 21.63% for high-inte
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- 2024
26. Sentinel-node biopsy in apparent early stage ovarian cancer: final results of a prospective multicentre study (SELLY)
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Nero, Camilla, Bizzarri, Nicolo', Di Berardino, Stefano, Sillano, F., Vizzielli, Giuseppe, Cosentino, F., Vargiu, V., De Iaco, P., Perrone, A. M., Vizza, E., Chiofalo, B., Uccella, S., Ghezzi, F., Turco, L. C., Corrado, Giacomo, Giannarelli, Diana, Pasciuto, Tina, Zannoni, Gian Franco, Fagotti, Anna, Scambia, Giovanni, Nero C., Bizzarri N., Di Berardino S., Vizzielli G., Corrado G., Giannarelli D., Pasciuto T. (ORCID:0000-0003-2959-8571), Zannoni G. F. (ORCID:0000-0003-1809-129X), Fagotti A. (ORCID:0000-0001-5579-335X), Scambia G. (ORCID:0000-0003-2758-1063), Nero, Camilla, Bizzarri, Nicolo', Di Berardino, Stefano, Sillano, F., Vizzielli, Giuseppe, Cosentino, F., Vargiu, V., De Iaco, P., Perrone, A. M., Vizza, E., Chiofalo, B., Uccella, S., Ghezzi, F., Turco, L. C., Corrado, Giacomo, Giannarelli, Diana, Pasciuto, Tina, Zannoni, Gian Franco, Fagotti, Anna, Scambia, Giovanni, Nero C., Bizzarri N., Di Berardino S., Vizzielli G., Corrado G., Giannarelli D., Pasciuto T. (ORCID:0000-0003-2959-8571), Zannoni G. F. (ORCID:0000-0003-1809-129X), Fagotti A. (ORCID:0000-0001-5579-335X), and Scambia G. (ORCID:0000-0003-2758-1063)
- Abstract
Aim: To evaluate the sensitivity and specificity of sentinel-lymph-node mapping compared with the gold standard of systematic lymphadenectomy in detecting lymph node metastasis in apparent early stage ovarian cancer. Methods: Multicenter, prospective, phase II trial, conducted in seven centers from March 2018 to July 2022. Patients with presumed stage I-II epithelial ovarian cancer planned for surgical staging were eligible. Patients received injection of indocyanine green in the infundibulo-pelvic and, when feasible, utero-ovarian ligaments and sentinel lymph node biopsy followed by pelvic and para-aortic lymphadenectomy was performed. Histopathological examination of all nodes was performed including ultra-staging protocol for the sentinel lymph node. Results: 174 patients were enrolled and 169 (97.1 %) received study interventions. 99 (58.6 %) patients had successful mapping of at least one sentinel lymph node and 15 (15.1 %) of them had positive nodes. Of these, 11 of 15 (73.3 %) had a correct identification of the disease in the sentinel lymph node; 7 of 11 (63.6 %) required ultra-staging protocol to detect nodal metastasis. Four (26.7 %) patients with node-positive disease had a negative sentinel-lymph-node (sensitivity 73.3 % and specificity 100.0 %). Conclusions: In a multicenter setting, identifying sentinel-lymph nodes in apparent early stage epithelial ovarian cancer did not reach the expected sensitivity: 1 of 4 patients might have metastatic lymphatic disease unrecognized by sentinel-lymph-node biopsy. Nevertheless, 35.0 % of node positive patients was identified only thanks to ultra-staging protocol on sentinel-lymph-nodes.
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- 2024
27. Progressive multifocal leukoencephalopathy
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Perrone, Christopher M., additional and Berger, Joseph R., additional
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- 2021
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28. Enhancing wellbeing and resilience in coaches: The impact of a mindfulnessbased intervention.
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Lebeau, Jean-Charles, Tremml, Brian, Perrone, Kristin M., and Judge, Lawrence W.
- Abstract
Mindfulness training, characterised by the cultivation of present-moment awareness and non-judgmental attention, has emerged as a potent tool for enhancing mental wellbeing and resilience in the face of life's challenges. In the realm of sports, its effectiveness in fortifying the mental resilience and performance of athletes and coaches has garnered significant attention. This study sought to investigate the impact of an online mindfulness-based intervention on the perceptions of stress, emotion regulation, and burnout among full-time coaches. Sixteen full-time coaches (nine females and seven males) engaged in a six-week online mindfulness-based intervention program, an adaptation of the Mindfulness Training for Coaches program, within the context of swimming as a sport. Participants completed a series of online questionnaires assessing their levels of mindfulness, emotion regulation, burnout, and stress. Data collection occurred before the intervention, at weeks three and five during the program, and post-intervention. Baseline data indicated that full-time coaches reported significant levels of burnout. The study's results unveiled notable improvements, with coaches experiencing (a) a significant reduction in difficulties associated with regulating emotions (p =.02) and stress (p <.001), (b) a noteworthy trend towards increased mindfulness scores (p =.08), and (c) a promising trend towards decreased burnout (p =.08). This investigation underscores the relevance of mindfulness participation in bolstering the wellbeing of full-time coaches, demonstrating its potential to enhance their mental fortitude and reduce the detrimental effects of stress and burnout. The implications extend beyond coaching, offering insights into the broader application of mindfulness interventions for improved mental wellbeing and performance within the sports arena. [ABSTRACT FROM AUTHOR]
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- 2024
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29. A real-time marker of object-based attention in the human brain. A possible component of a “gate-keeping mechanism” performing late attentional selection in the Ventro-Lateral Prefrontal Cortex
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Perrone-Bertolotti, M., El Bouzaïdi Tiali, S., Vidal, J.R., Petton, M., Croize, A.C., Deman, P., Rheims, S., Minotti, L., Bhattacharjee, M., Baciu, M., Kahane, P., and Lachaux, J.P.
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- 2020
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30. Seeing Santurbán through ISDS: A sociolegal case study of Eco Oro v. Colombia
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Cotula, Lorenzo, primary and Perrone, Nicolás M., additional
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- 2024
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31. THE "INVISIBLE" LOCAL COMMUNITIES : FOREIGN INVESTOR OBLIGATIONS, INCLUSIVENESS, AND THE INTERNATIONAL INVESTMENT REGIME
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Perrone, Nicolás M.
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- 2019
32. Multigenerational Giftedness: Perceptions of Giftedness across Three Generations
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Perrone, Kristin M., Ksiazak, Tracy M., and Wright, Stephen L.
- Abstract
The focus of this study was on gifted adults' perceptions of multigenerational giftedness in their families. Participants have been surveyed annually since their high school graduation in 1988. The purpose of the longitudinal study is to gain insight into the career and life development of gifted individuals post-high school. For the present follow-up study, data were collected via the Internet and mailed surveys and analyzed by a 5-member research team. Participants reported their perceptions of whether or not their parents and children were gifted and the areas of giftedness. The number of participants who perceived both parents to be gifted was roughly equal to those stating that neither parent was gifted. Areas of perceived giftedness differed between mothers and fathers. The majority of participants identified at least one of their children as gifted. Specific areas of giftedness perceived in participants' children and parents are described. Implications of the findings are discussed. (Contains 3 tables.)
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- 2010
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33. Renal Complications and Their Management After Adult Cardiac Surgery
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Perrone, Juan M., Cudemus, Gaston, Dabbagh, Ali, editor, Esmailian, Fardad, editor, and Aranki, Sary, editor
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- 2018
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34. Conclusion
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Perrone, Nicolás M., primary
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- 2021
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35. The Rise of Investment Treaties and ISDS in the 1990s and Since
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Perrone, Nicolás M., primary
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- 2021
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36. Investment Treaties and the Legal Imagination
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Perrone, Nicolás M., primary
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- 2021
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37. Givings and ISDS
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Perrone, Nicolás M., primary
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- 2021
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38. ISDS in Action
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Perrone, Nicolás M., primary
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- 2021
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39. Introduction
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Perrone, Nicolás M., primary
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- 2021
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40. Local Communities and ISDS
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Perrone, Nicolás M., primary
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- 2021
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41. The Norm Entrepreneurs of the 1950s and 1960s
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Perrone, Nicolás M., primary
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- 2021
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42. Foreign Investor Rights and Investment Relations
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Perrone, Nicolás M., primary
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- 2021
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43. Competing Imaginaries and the 1970s
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Perrone, Nicolás M., primary
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- 2021
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44. Investors’ International Law and its Asymmetries: The Case of Local Communities
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Cotula, Lorenzo, primary and Perrone, Nicolás M, additional
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- 2021
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45. Electrochemotherapy – Emerging applications technical advances, new indications, combined approaches, and multi-institutional collaboration
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Campana, Luca G., Edhemovic, Ibrahim, Soden, Declan, Perrone, Anna M., Scarpa, Marco, Campanacci, Laura, Cemazar, Maja, Valpione, Sara, Miklavčič, Damijan, Mocellin, Simone, Sieni, Elisabetta, and Sersa, Gregor
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- 2019
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46. Seeing Santurbán through ISDS: A sociolegal case study of Eco Orov. Colombia
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Cotula, Lorenzo and Perrone, Nicolás M.
- Abstract
AbstractThis article aims to enrich the emerging, multi-coloured tapestry of ‘international law in context’ through a study of how international economic law operates in complex investment-related disputes. Focusing on the Eco Orov. Colombiainvestor-state arbitration, and drawing on both doctrinal analysis and sociolegal research, the study investigates how different actors make sense of the issues, of the dispute, and of the law. Besides shedding light on the neglected multi-actor, multi-layered dimensions of investment disputes, and on tensions between often incommensurable values, juxtaposing arbitral proceedings and underlying social realities highlights how investor-state arbitration involves a socio-political process of re-presenting actors, territory, the environment, and livelihoods through the prism of international arrangements that are primarily designed to protect foreign investment. The findings provide policy pointers on the need for systemic reform of international investment law, moving away from the predominant emphasis on investment protection and investor-state dispute settlement, towards a governance model that effectively considers the social, political, and environmental dimensions of foreign investment projects.
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- 2024
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47. International Investment Law as Transnational Law
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Perrone, Nicolás M. and Zumbansen, Peer, book editor
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- 2021
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48. Combination of Electrochemotherapy with Radiotherapy: A Comprehensive, Systematic, PRISMA-Compliant Review of Efficacy and Potential Radiosensitizing Effects in Tumor Control
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Ferioli, Martina, primary, Perrone, Anna M., additional, Buwenge, Milly, additional, Arcelli, Alessandra, additional, Vadala’, Maria, additional, Fionda, Bruno, additional, Malato, Maria C., additional, De Iaco, Pierandrea, additional, Zamagni, Claudio, additional, Cammelli, Silvia, additional, Tagliaferri, Luca, additional, and Morganti, Alessio G., additional
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- 2023
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49. Mapping the Relationship of White Matter Lesions to Depression in Multiple Sclerosis
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Baller, Erica B., primary, Sweeney, Elizabeth M., additional, Cieslak, Matthew, additional, Robert-Fitzgerald, Timothy, additional, Covitz, Sydney C., additional, Martin, Melissa L., additional, Schindler, Matthew K., additional, Bar-Or, Amit, additional, Elahi, Ameena, additional, Larsen, Bart S., additional, Manning, Abigail R., additional, Markowitz, Clyde E., additional, Perrone, Christopher M., additional, Rautman, Victoria, additional, Seitz, Madeleine M., additional, Detre, John A., additional, Fox, Michael D., additional, Shinohara, Russell T., additional, and Satterthwaite, Theodore D., additional
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- 2023
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50. Governing Global Capitalism: A Lawyer's Perspective
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Perrone, Nicolás M., primary
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- 2023
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