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Sylvie Callejon,1,2 Félix Giraud,1,2 Florence Larue,1 Armonie Buisson,1 Léa Mateos,1,2 Laurence Grare,1 Aurélie Guyoux,1 Eric Perrier,2 Nathalie Ardiet,1 Sandra Trompezinski1,2 1NAOS Group, Research and Development Department, Aix-en-Provence, France; 2NAOS Institute of Life Science, Aix-en-Provence, FranceCorrespondence: Sandra Trompezinski, 355 Rue Pierre Simon Laplace, 13593 Aix-en-Provence Cedex 03, Aix-en-Provence, France, Tel +33 4 42 60 73 65, Email sandra.trompezinski@naos.comPurpose: Skincare products are used daily to maintain a healthy skin, although their skin microbiome impact is still poorly known. Preserving the natural resources and mechanisms of the skin ecosystem is essential, and a novel approach based on these premises, called ecobiology, has recently emerged in skincare. We evaluated the impact on the skin microbiome of three types of leave-on face skincare products: a hydrophilic solution, a micellar solution, and an oil-in-water emulsion.Patients and Methods: Samples for microbial profiling were obtained from 20 Caucasian females twenty-four hours and four days following daily application of the skincare products and compared to an untreated area. The bacterial diversity and the abundance of the skin microbiome were analyzed by 16S rRNA gene sequencing using an Illumina MiSeq platform.Results: Our results confirmed the skin microbiome diversity and the prevalence of Cutibacterium spp. and Staphylococcus spp. at sebaceous sites. The bacterial diversity and abundance were not affected by the products, and no dissimilarities versus the control nor between each product were noted at both times.Conclusion: These preliminary results demonstrate for the first time that three types of leave-on face skincare products have no impact on the human skin microbiome and can be considered to be “microbiome friendly”.Keywords: cosmetic product, ecobiology, microbiome friendly

The extremely successful Standard Model of Particle Physics allows one to define the so-called Elementary Particles. From another point of view, how can we think of them? What kind of a status can be attributed to Elementary Particles and their associated quantised fields? Beyond the unprecedented efficiency and reach of quantum field theories, the current paper attempts at understanding the nature of what these theories describe, the enigmatic reality of the quantum world., Author(s): D.-M. Cabaret [sup.1], T. Grandou [sup.2], G.-M. Grange [sup.3], E. Perrier [sup.3] Author Affiliations: (1) Couvent Saint Etienne, , Jerusalem, Israel (2) grid.497397.7, 0000 0000 9497 6864, Université Côte [...]

BACKGROUND/OBJECTIVES: In sedentary adults, hydration is mostly influenced by total fluid intake and not by sweat losses; moreover, low daily fluid intake is associated with adverse health outcomes. This study aimed to model the relation between total fluid intake and urinary hydration biomarkers. SUBJECTS/METHODS: During 4 consecutive weekdays, 82 adults (age, 31.6 ± 4.3 years; body mass index, 23.2 ± 2.7 kg/[m.sup.2]; 52% female) recorded food and fluid consumed, collected one first morning urine (FMU) void and three 24-h (24hU) samples. The strength of linear association between urinary hydration biomarkers and fluid intake volume was evaluated using simple linear regression and Pearson's correlation. Multivariate partial least squares (PLS) modeled the association between fluid intake and 24hU hydration biomarkers. RESULTS: Strong associations ([absolute value of r] [greater than or equal to] 0.6; P < 0.001) were found between total fluid intake volume and 24hU osmolality, color, specific gravity (USG), volume and solute concentrations. Many 24hU biomarkers were collinear (osmolality versus color: r = 0.49-0.76; USG versus color: r = 0.46-0.78; osmolality versus USG: 0.86-0.97; P < 0.001). Measures in FMU were not strongly correlated to intake. Multivariate PLS and simple linear regression using urine volume explained > 50% of the variance in fluid intake volume ([r.sup.2] = 0.59 and 0.52, respectively); however the error in both models was high and the limits of agreement very large. CONCLUSIONS: Hydration biomarkers in 24hU are strongly correlated with daily total fluid intake volume in sedentary adults in free-living conditions; however, the margin of error in the present models limits the applicability of estimating fluid intake from urinary biomarkers. European Journal of Clinical Nutrition (2013) 67, 939-943; doi:10.1038/ejcn.2013.93; published online 22 May 2013 Keywords: osmolality; urination; hydration; beverages; water; intake, INTRODUCTION Water is essential for a wide variety of physiological functions, and water intake must be sufficient to compensate for daily losses. Low daily water intake and low urine output [...]

Growing evidence suggests a distinction between water intake necessary for maintaining a euhydrated state, and water intake considered to be adequate from a perspective of long-term health. Previously, we have proposed that maintaining a 24-h urine osmolality (U[sub.Osm]) of [precedes/equal to]500 mOsm/kg is a desirable target for urine concentration to ensure sufficient urinary output to reduce renal health risk and circulating vasopressin. In clinical practice and field monitoring, the measurement of U[sub.Osm] is not practical. In this analysis, we calculate criterion values for urine-specific gravity (U[sub.SG]) and urine color (U[sub.Col]), two measures which have broad applicability in clinical and field settings. A receiver operating characteristic curve analysis performed on 817 urine samples demonstrates that a U[sub.SG] [succeeds/equal to]1.013 detects U[sub.Osm] [greater than] 500 mOsm/kg with very high accuracy (AUC 0.984), whereas a subject-assessed U[sub.Col][succeeds/equal to]4 offers high sensitivity and moderate specificity (AUC 0.831) for detecting U[sub.Osm] [greater than] 500 m Osm/kg. European Journal of Clinical Nutrition (2017) 71, 561-563; doi: 10.1038/ejcn.2016.269; published online 1 February 2017, Author(s): E T Perrier [1]; J H Bottin [1]; M Vecchio [1]; G Lemetais [1] Introduction Water is essential to life, represents the largest single nutrient in terms of intake, [...]