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1. Efficacy and Safety of Tranexamic Acid in Cancer Surgery. An Update of Clinical Findings and Ongoing Research

Author

Zec T, Di Napoli R, Fievez L, Ben Aziz M, Ottaiano A, Vittori A, Perri F, and Cascella M

Subjects
tranexamic acid, cancer surgery, oncology, anemia, blood trasfusion, anti-fibrinolytic, Medicine (General), R5-920
Abstract

Tamara Zec,1 Raffaela Di Napoli,1 Lydwine Fievez,1 Mohamed Ben Aziz,1 Alessandro Ottaiano,2 Alessandro Vittori,3 Francesco Perri,4 Marco Cascella5 1Department of Anesthesiology, Institut Jules Bordet, Université Libre de Bruxelles, Bruxelles, 1000, Belgium; 2SSD Innovative Therapies for Abdominal Metastases, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, 80100, Italy; 3Department of Anesthesia and Critical Care, ARCO ROMA, Ospedale Pediatrico Bambino Gesù IRCCS, Piazza S. Onofrio 4, Rome, 00165, Italy; 4Medical and Experimental Head and Neck Oncology Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, 80100, Italy; 5Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, 80100, ItalyCorrespondence: Francesco Perri, Email f.perri@istitutotumori.na.itAbstract: In cancer patients undergoing surgery, tumor biology and anticancer treatments can increase the risk of perioperative bleeding and blood transfusions. Notably, blood transfusions can be potentially associated with an increased risk of life-threatening immune responses, acute lung injury, postoperative infections, and thromboembolism. Moreover, the link between perioperative transfusion and increased risk of cancer recurrence cannot be excluded. On the other hand, cancer patients have an increased risk of thromboembolism due to cancer itself and antineoplastic systemic treatments including chemotherapy and anti-angiogenic drugs. In this complex scenario, effective and safe strategies aimed at the prevention of blood transfusions are warranted. This narrative review addresses the efficacy, and the safety of the synthetic antifibrinolytic agent tranexamic acid (TXA) when used perioperatively in cancer surgery. Although in not oncologic surgery the use of TXA has been extensively studied, in the setting of cancer patients requiring surgery, the evidence is scarce. An overview of the ongoing clinical research is also provided.Keywords: tranexamic acid, cancer surgery, oncology, anemia, blood transfusion, anti-fibrinolytic

Published
2022

2. Single nucleotide polymorphisms and unacceptable late toxicity in breast cancer adjuvant radiotherapy: a case report

Author

Lazzari G, Natalicchio MI, Terlizzi A, Perri F, and Silvano G

Subjects
radiosensivity, SNP's, fibrosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Grazia Lazzari,1 Maria Iole Natalicchio,2 Angela Terlizzi,3 Francesco Perri,4 Giovanni Silvano1 1Radiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, 2Molecular Biology Laboratory, Pathological Anatomy Department, Ospedali Riuniti, Foggia, 3Medical Physic Unit, San Giuseppe Moscati Hospital, 4Medical Oncology Unit, Presidio Ospedaliero Centrale - Santissima Annunziata, Taranto, Italy Background: There has recently been a strong interest in the inter-individual variation in normal tissue and tumor response to radiotherapy (RT), because tissue radiosensitivity seems to be under genetic control. Evidence is accumulating on the role of polymorphic genetic variants, such as single nucleotide polymorphisms (SNPs) that could influence normal tissue response after radiation. The most studied SNPs include those in genes involved in DNA repair (single- and double-strand breaks, and base excision) and those active in the response to oxidative stress.Case report: We present the case report of a 60-year-old woman with early breast cancer who underwent adjuvant hormone therapy and conventional radiotherapy, and subsequently developed unacceptable cosmetic toxicities of the irradiated breast requiring a genetic test of genes involved in DNA repair mechanisms. The patient was found to be heterozygous for G28152A (T/C) and C18067T (A/G) mutations in X-ray repair cross-complementing group 1 (XRCC1) and 3 (XRCC3), respectively, homozygous for A313G (G/G) mutation in glutathione S transferase Pi 1 (GSTP1), and wild-type for A4541G (A/A) in XRCC3 and G135C (G/G) in RAD51 recombinase.Conclusion: The role of SNPs should be taken into account when a severe phenomenon appears in normal tissues after radiation treatment, because understanding the molecular basis of individual radiosensitivity may be useful for identifying moderately or extremely radiosensitive patients who may need tailored therapeutic strategies. Keywords: radiosensitivity, SNPs, fibrosis, DNA repair

Published
2017

3. Multi-year characterisation of the broad-band emission from the intermittent extreme BL Lac 1ES~2344+514

Author

Abe, H., Abe, S., Acciari, V. A., Agudo, I., Aniello, T., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Arcaro, C., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., de Almeida, U. Barres, Batković, I., Baxter, J., González, J. Becerra, Bernardini, E., Bernete, J., Berti, A., Besenrieder, J., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bošjak, Ž, Burelli, I., Busetto, G., Campoy-Ordaz, A., Carosi, A., Carosi, R., Carretero-Castrillo, M., Castro-Tirado, A. J., Chai, Y., Cifuentes, A., Cikota, S., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Ammando, F., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Del Popolo, A., Delfino, M., Delgado, J., Mendez, C. Delgado, Depaoli, D., Di Pierro, F., Di Venere, L., Prester, D. Dominis, Dorner, D., Doro, M., Elsaesser, D., Emery, G., Escudero, J., Fariña, L., Fattorini, A., Foffano, L., Font, L., Fukami, S., Fukazawa, Y., López, R. J. García, Gasparyan, S., Gaug, M., Paiva, J. G. Giesbrecht, Giglietto, N., Giordano, F., Gliwny, P., Grau, R., Green, J. G., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hrupec, D., Hütten, M., Imazawa, R., Inada, T., Iotov, R., Ishio, K., Martínez, I. Jiménez, Jormanainen, J., Kerszberg, D., Kluge, G. W., Kobayashi, Y., Kouch, P. M., Kubo, H., Kushida, J., Lezáun, M. Láinez, Lamastra, A., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Moya, M., López-Oramas, A., Loporchio, S., Lorini, A., Fraga, B. Machado de Oliveira, Majumdar, P., Makariev, M., Maneva, G., Mang, N., Manganaro, M., Mariotti, M., Martínez, M., Martínez-Chicharro, M., Mas-Aguilar, A., Mazin, D., Menchiari, S., Mender, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., González, M. Molero, Molina, E., Mondal, H. A., Moralejo, A., Morcuende, D., Nakamori, T., Nanci, C., Neustroev, V., Nigro, C., Nikolić, L., Nishijima, K., Ekoume, T. Njoh, Noda, K., Nozaki, S., Ohtani, Y., Okumura, A., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavlović, D., Persic, M., Pihet, M., Pirola, G., Podobnik, F., Moroni, P. G. Prada, Prandini, E., Principe, G., Priyadarshi, C., Rhode, W., Ribó, M., Rico, J., Righi, C., Sahakyan, N., Saito, T., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schmuckermaier, F., Schubert, J. L., Schweizer, T., Sciaccaluga, A., Sitarek, J., Spolon, A., Stamerra, A., Strišović, J., Strom, D., Suda, Y., Tajima, H., Takeishi, R., Tavecchio, F., Temnikov, P., Terauchi, K., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Ventura, S., Verguilov, V., Viale, I., Vigorito, C. F., Vitale, V., Walter, R., Wunderlich, C., Leto, T. Yamamoto M. Perri F. Verrecchia C., Das, S., Chatterjee, R., Raiteri, C. M., Villata, M., Semkov, E., Ibryamov, S., Bachev, R., Strigachev, A., Damljanovic, G., Vince, O., Jovanovic, M. D., Stojanovic, M., Larionov, V. M., Grishina, T. S., Kopatskaya, E. N., Larionova, E. G., Morozova, D. A., Savchenko, S. S., Troitskiy, I. S., Troitskaya, Y. V., Vasilyev, A. A., Chen, W. P., Hou, W. J., Lin, C. S., Tsai, A., Jorstad, S. G., Weaver, Z. R., Acosta-Pulido, J. A., Carnerero, M. I., Carosati, D., Kurtanidze, S. O., Kurtanidze, O. M., Jordan, B., Ivanidze, R. Z., Gazeas, K., Vrontaki, K., Hovatta, T., Liodakis, I., Readhead, A. C. S., Kiehlmann, S., Zheng, W., and Filippenko, A. V.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The BL Lac 1ES 2344+514 is known for temporary extreme properties (e.g., a shift of the synchrotron SED peak energy $\nu_{synch,p}$ above 1keV). While those extreme states were so far observed only during high flux levels, additional multi-year observing campaigns are required to achieve a coherent picture. Here, we report the longest investigation of the source from radio to VHE performed so far, focusing on a systematic characterisation of the intermittent extreme states. While our results confirm that 1ES 2344+514 typically exhibits $\nu_{synch,p}>$1keV during elevated flux periods, we also find periods where the extreme state coincides with low flux activity. A strong spectral variability thus happens in the quiescent state, and is likely caused by an increase of the electron acceleration efficiency without a change in the electron injection luminosity. We also report a strong X-ray flare (among the brightest for 1ES 2344+514) without a significant shift of $\nu_{synch,p}$. During this particular flare, the X-ray spectrum is among the softest of the campaign. It unveils complexity in the spectral evolution, where the common harder-when-brighter trend observed in BL Lacs is violated. During a low and hard X-ray state, we find an excess of the UV flux with respect to an extrapolation of the X-ray spectrum to lower energies. This UV excess implies that at least two regions contribute significantly to the infrared/optical/ultraviolet/X-ray emission. Using the simultaneous MAGIC, XMM-Newton, NuSTAR, and AstroSat observations, we argue that a region possibly associated with the 10 GHz radio core may explain such an excess. Finally, we investigate a VHE flare, showing an absence of simultaneous variability in the 0.3-2keV band. Using a time-dependent leptonic modelling, we show that this behaviour, in contradiction to single-zone scenarios, can instead be explained by a two-component model., Comment: Accepted for publication in Astronomy & Astrophysics

Published
2023
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4. On the statistical assessment of classifiers using DNA microarray data

Author

Carella M, Liuni S, Savino M, Cotugno R, D'Addabbo A, Piepoli A, Maglietta R, Ancona N, Pesole G, and Perri F

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5
Abstract

Abstract Background In this paper we present a method for the statistical assessment of cancer predictors which make use of gene expression profiles. The methodology is applied to a new data set of microarray gene expression data collected in Casa Sollievo della Sofferenza Hospital, Foggia – Italy. The data set is made up of normal (22) and tumor (25) specimens extracted from 25 patients affected by colon cancer. We propose to give answers to some questions which are relevant for the automatic diagnosis of cancer such as: Is the size of the available data set sufficient to build accurate classifiers? What is the statistical significance of the associated error rates? In what ways can accuracy be considered dependant on the adopted classification scheme? How many genes are correlated with the pathology and how many are sufficient for an accurate colon cancer classification? The method we propose answers these questions whilst avoiding the potential pitfalls hidden in the analysis and interpretation of microarray data. Results We estimate the generalization error, evaluated through the Leave-K-Out Cross Validation error, for three different classification schemes by varying the number of training examples and the number of the genes used. The statistical significance of the error rate is measured by using a permutation test. We provide a statistical analysis in terms of the frequencies of the genes involved in the classification. Using the whole set of genes, we found that the Weighted Voting Algorithm (WVA) classifier learns the distinction between normal and tumor specimens with 25 training examples, providing e = 21% (p = 0.045) as an error rate. This remains constant even when the number of examples increases. Moreover, Regularized Least Squares (RLS) and Support Vector Machines (SVM) classifiers can learn with only 15 training examples, with an error rate of e = 19% (p = 0.035) and e = 18% (p = 0.037) respectively. Moreover, the error rate decreases as the training set size increases, reaching its best performances with 35 training examples. In this case, RLS and SVM have error rates of e = 14% (p = 0.027) and e = 11% (p = 0.019). Concerning the number of genes, we found about 6000 genes (p < 0.05) correlated with the pathology, resulting from the signal-to-noise statistic. Moreover the performances of RLS and SVM classifiers do not change when 74% of genes is used. They progressively reduce up to e = 16% (p < 0.05) when only 2 genes are employed. The biological relevance of a set of genes determined by our statistical analysis and the major roles they play in colorectal tumorigenesis is discussed. Conclusions The method proposed provides statistically significant answers to precise questions relevant for the diagnosis and prognosis of cancer. We found that, with as few as 15 examples, it is possible to train statistically significant classifiers for colon cancer diagnosis. As for the definition of the number of genes sufficient for a reliable classification of colon cancer, our results suggest that it depends on the accuracy required.

Published
2006
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5. A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma

Author

Giaccherini, M, primary, Rende, M, additional, Gentiluomo, M, additional, Corradi, C, additional, Archibugi, L, additional, Ermini, S, additional, Maiello, E, additional, Morelli, L, additional, van Eijck, C H J, additional, Cavestro, G M, additional, Schneider, M, additional, Mickevicius, A, additional, Adamonis, K, additional, Basso, D, additional, Hlavac, V, additional, Gioffreda, D, additional, Talar-Wojnarowska, R, additional, Schöttker, B, additional, Lovecek, M, additional, Vanella, G, additional, Gazouli, M, additional, Uno, M, additional, Malecka-Wojciesko, E, additional, Vodicka, P, additional, Goetz, M, additional, Bijlsma, M F, additional, Petrone, M C, additional, Bazzocchi, F, additional, Kiudelis, M, additional, Szentesi, A, additional, Carrara, S, additional, Nappo, G, additional, Brenner, H, additional, Milanetto, A C, additional, Soucek, P, additional, Katzke, V, additional, Peduzzi, G, additional, Rizzato, C, additional, Pasquali, C, additional, Chen, X, additional, Capurso, G, additional, Hackert, T, additional, Bueno-de-Mesquita, B, additional, Uzunoglu, F G G, additional, Hegyi, P, additional, Greenhalf, W, additional, Theodoropoulos, G E E, additional, Sperti, C, additional, Perri, F, additional, Oliverius, M, additional, Mambrini, A, additional, Tavano, F, additional, Farinella, R, additional, Arcidiacono, P G, additional, Lucchesi, M, additional, Bunduc, S, additional, Kupcinskas, J, additional, Di Franco, G, additional, Stocker, S, additional, Neoptolemos, J P, additional, Bambi, F, additional, Jamroziak, K, additional, Testoni, S G G, additional, Aoki, M N, additional, Mohelnikova-Duchonova, B, additional, Izbicki, J R, additional, Pezzilli, R, additional, Lawlor, R T, additional, Kauffmann, E F, additional, López de Maturana, E, additional, Malats, N, additional, Canzian, F, additional, and Campa, D, additional

Published
2024
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6. Absolute basophil count is associated with time to recurrence in patients with high-grade T1 bladder cancer receiving bacillus Calmette–Guérin after transurethral resection of the bladder tumor

Author

Ferro, M., Di Lorenzo, G., Vartolomei, M. D., Bruzzese, D., Cantiello, F., Lucarelli, G., Musi, G., Di Stasi, S., Hurle, R., Guazzoni, G., Busetto, G. M., Gabriele, A., Del Giudice, F., Damiano, R., Perri, F., Perdona, S., Verze, P., Borghesi, M., Schiavina, R., Almeida, G. L., Bove, P., Lima, E., Autorino, R., Crisan, N., Farhan, A. R. Abu, Battaglia, M., Russo, G. I., Ieluzzi, Vincenzo, Morgia, G., De Placido, P., Terracciano, D., Cimmino, A., Scafuri, L., Mirone, V., De Cobelli, O., Shariat, S., Sonpavde, Guru, and Buonerba, C.

Published
2020
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9. MOLECULAR SUBTYPES AND DIETARY PATTERNS IN BREAST CANCER PATIENTS: A LATENT CLASS ANALYSIS

Author

Crispo, A., primary, Coluccia, S., additional, Vitale, S., additional, Palumbo, E., additional, Porciello, G., additional, Luongo, A., additional, Prete, M., additional, Coppola, E., additional, Montagnese, C., additional, Di Gennaro, P., additional, Grimaldi, M., additional, Pica, R., additional, Rotondo, E., additional, Celentano, E., additional, Izzo, F., additional, Amore, A., additional, Cascella, M., additional, Perri, F., additional, De Laurentiis, M., additional, and Augustin, L.S.A., additional

Published
2023
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12. Endoscopic papillectomy: a multicenter, retrospective, nationwide study after the standardization of the technique

Author

Binda, C., additional, Fabbri, S., additional, Cucchetti, A., additional, Mutignani, M., additional, Tringali, A., additional, Di Mitri, R., additional, Fugazza, A., additional, Sassatelli, R., additional, Gabbrielli, A., additional, Arcidiacono, P., additional, Di Matteo, F. M., additional, Coluccio, C., additional, Di Marco, M., additional, Spada, C., additional, Fantin, A., additional, De Angelis, C. G., additional, Macchiarelli, R., additional, Perri, F., additional, Manno, M., additional, Cugia, L., additional, Mussetto, A., additional, Dioscoridi, L., additional, Schepis, T., additional, Scimeca, D., additional, Da Rio, L., additional, Cecinato, P., additional, Crinò, S. F., additional, Repici, A., additional, Tarantino, I., additional, Anderloni, A., additional, Fabbri, C., additional, and I-Eus, G., additional

Published
2023
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14. OC.13.2 ENDOSCOPIC PAPILLECTOMY: A MULTICENTER, RETROSPECTIVE, NATIONWIDE STUDY AFTER THE STANDARDISATION OF THE TECHNIQUE

Author

Binda, C., primary, Fabbri, S., additional, Cucchetti, A., additional, Mutignani, M., additional, Tringali, A., additional, Di Mitri, R., additional, Fugazza, A., additional, Sassatelli, R., additional, Gabbrielli, A., additional, Arcidiacono, P.G., additional, Di Matteo, F., additional, Coluccio, C., additional, Di Marco, M., additional, Spada, C., additional, Fantin, A., additional, De Angelis, C., additional, Macchiarelli, R., additional, Perri, F., additional, Manno, M., additional, Cugia, L., additional, Mussetto, A., additional, Schepis, T., additional, Scimeca, D., additional, Da Rio, L., additional, Cecinato, P., additional, Crino, S., additional, Repici, A., additional, Tarantino, I., additional, Anderloni, A., additional, Fabbri, C., additional, and I-Eus, G., additional

Published
2023
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16. Gut virome-colonising Orthohepadnavirus genus is associated with ulcerative colitis pathogenesis and induces intestinal inflammation in vivo

Author

Massimino, L, Palmieri, O, Facoetti, A, Fuggetta, D, Spanò, S, Lamparelli, L, D'Alessio, S, Cagliani, S, Furfaro, F, D'Amico, F, Zilli, A, Fiorino, G, Parigi, T, Noviello, D, Latiano, A, Bossa, F, Latiano, T, Pirola, A, Mologni, L, Piazza, R, Abbati, D, Perri, F, Bonini, C, Peyrin-Biroulet, L, Malesci, A, Jairath, V, Danese, S, Ungaro, F, Massimino, Luca, Palmieri, Orazio, Facoetti, Amanda, Fuggetta, Davide, Spanò, Salvatore, Lamparelli, Luigi Antonio, D'Alessio, Silvia, Cagliani, Stefania, Furfaro, Federica, D'Amico, Ferdinando, Zilli, Alessandra, Fiorino, Gionata, Parigi, Tommaso Lorenzo, Noviello, Daniele, Latiano, Anna, Bossa, Fabrizio, Latiano, Tiziana, Pirola, Alessandra, Mologni, Luca, Piazza, Rocco Giovanni, Abbati, Danilo, Perri, Francesco, Bonini, Chiara, Peyrin-Biroulet, Laurent, Malesci, Alberto, Jairath, Vipul, Danese, Silvio, Ungaro, Federica, Massimino, L, Palmieri, O, Facoetti, A, Fuggetta, D, Spanò, S, Lamparelli, L, D'Alessio, S, Cagliani, S, Furfaro, F, D'Amico, F, Zilli, A, Fiorino, G, Parigi, T, Noviello, D, Latiano, A, Bossa, F, Latiano, T, Pirola, A, Mologni, L, Piazza, R, Abbati, D, Perri, F, Bonini, C, Peyrin-Biroulet, L, Malesci, A, Jairath, V, Danese, S, Ungaro, F, Massimino, Luca, Palmieri, Orazio, Facoetti, Amanda, Fuggetta, Davide, Spanò, Salvatore, Lamparelli, Luigi Antonio, D'Alessio, Silvia, Cagliani, Stefania, Furfaro, Federica, D'Amico, Ferdinando, Zilli, Alessandra, Fiorino, Gionata, Parigi, Tommaso Lorenzo, Noviello, Daniele, Latiano, Anna, Bossa, Fabrizio, Latiano, Tiziana, Pirola, Alessandra, Mologni, Luca, Piazza, Rocco Giovanni, Abbati, Danilo, Perri, Francesco, Bonini, Chiara, Peyrin-Biroulet, Laurent, Malesci, Alberto, Jairath, Vipul, Danese, Silvio, and Ungaro, Federica

Abstract

Objectives: Ulcerative colitis (UC) is a chronic inflammatory disorder of unknown aetiology. Gut virome dysbiosis is fundamental in UC progression, although its role in the early phases of the disease is far from fully understood. Therefore, we sought to investigate the role of a virome-associated protein encoded by the Orthohepadnavirus genus, the hepatitis B virus X protein (HBx), in UC aetiopathogenesis. Design: HBx positivity of UC patient-derived blood and gut mucosa was assessed by RT-PCR and Sanger sequencing and correlated with clinical characteristics by multivariate analysis. Transcriptomics was performed on HBx-overexpressing endoscopic biopsies from healthy donors. C57BL/6 mice underwent intramucosal injections of liposome-conjugated HBx-encoding plasmids or the control, with or without antibiotic treatment. Multidimensional flow cytometry analysis was performed on colonic samples from HBx-treated and control animals. Transepithelial electrical resistance measurement, proliferation assay, chromatin immunoprecipitation assay with sequencing and RNA-sequencing were performed on in vitro models of the gut barrier. HBx-silencing experiments were performed in vitro and in vivo. Results: HBx was detected in about 45% of patients with UC and found to induce colonic inflammation in mice, while its silencing reverted the colitis phenotype in vivo. HBx acted as a transcriptional regulator in epithelial cells, provoking barrier leakage and altering both innate and adaptive mucosal immunity ex vivo and in vivo. Conclusion: This study described HBx as a contributor to the UC pathogenesis and provides a new perspective on the virome as a target for tailored treatments.

Published
2023

17. The role of non-skeletal carbonate component in Mediterranean Coralligenous: new insight from the CRESCIBLUREEF project

Author

Cipriani, M, Basso, D, Bazzicalupo, P, Bertolino, M, Bracchi, V, Bruno, F, Costa, G, Dominici, R, Gallo, A, Muzzapappa, M, Rosso, A, Perri, F, Sanfilippo, R, Sciuto, F, Guido, A, Cipriani, Mara, Basso, Daniela, Bazzicalupo, Pietro, Bertolino, Marco, Bracchi, Valentina Alice, Bruno, Fabio, Costa, Gabriele, Dominici, Rocco, Gallo, Alessandro, Muzzapappa, Maurizio, Rosso, Antonietta, Perri, Francesco, Sanfilippo, Rossana, Sciuto, Francesco, Guido, Adriano, Cipriani, M, Basso, D, Bazzicalupo, P, Bertolino, M, Bracchi, V, Bruno, F, Costa, G, Dominici, R, Gallo, A, Muzzapappa, M, Rosso, A, Perri, F, Sanfilippo, R, Sciuto, F, Guido, A, Cipriani, Mara, Basso, Daniela, Bazzicalupo, Pietro, Bertolino, Marco, Bracchi, Valentina Alice, Bruno, Fabio, Costa, Gabriele, Dominici, Rocco, Gallo, Alessandro, Muzzapappa, Maurizio, Rosso, Antonietta, Perri, Francesco, Sanfilippo, Rossana, Sciuto, Francesco, and Guido, Adriano

Abstract

In the frame of the project FISR_04543 “CRESCIBLUREEF - Grown in the blue: new technologies for knowledge and conservation of Mediterranean reefs”, we present preliminary data on the ecological and depositional implications of micritic sediments in a coralligenous bioconstruction formed along the Mediterranean shelf in front of the Marzamemi village (Sicily, Italy). The framework of the buildup is mainly built by crustose coralline algae, which in turn create the substrate for a high-diversified epi- and infaunal community. Two types of microcrystalline calcite, tentatively interpreted as allochthonous and autochthonous micrite, strictly related to fine skeletal debris, have been detected. The allochthonous micrite derive from abiotic accumulation of fine sediments in the framework cavities. The autochthonous micrite is deposited in situ through organic-mediated processes. The occurrence of this component allows hypothesizing a possible contribution of non-skeletal carbonate in the strengthening of the primary framework due to its syndepositional cementation.

Published
2023

18. OP32 The gut virome-colonizing Orthohepadnavirus genus is associated with ulcerative colitis pathogenesis and induces intestinal inflammation in vivo

Author

Facoetti, A, primary, Massimino, L, additional, Palmieri, O, additional, Fuggetta, D, additional, Spanò, S, additional, D'Alessio, S, additional, Furfaro, F, additional, D'Amico, F, additional, ZIlli, A, additional, Fiorino, G, additional, Noviello, D, additional, Latiano, A, additional, Bossa, F, additional, Pirola, A, additional, Mologni, L, additional, Piazza, R, additional, Abbati, D, additional, Perri, F, additional, Bonini, C, additional, Peyrin-Biroulet, L, additional, Malesci, A, additional, Danese, S, additional, and Ungaro, F, additional

Published
2023
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20. Evaluation of factors associated with trust in telemedicine in patients with inflammatory bowel disease during COVID-19 pandemic: a multicenter cross-sectional survey

Author

Bossa, F, Valvano, Mr, Vetrone, Lm, Guerra, M, Lopetuso, Loris Riccardo, Carparelli, S, Mignini, Irene, Cocomazzi, F, Napolitano, Daniele, Costantino, A, Caprioli, F, Gasbarrini, Antonio, Perri, F, and Papa, Alfredo

Subjects
Cross-Sectional Studies, Telemon-itoring, Settore MED/12 - GASTROENTEROLOGIA, Chronic Disease, Humans, COVID-19, Trust, Inflammatory Bowel Diseases, Pandemics, Leukocyte L1 Antigen Complex, Inflammatory bowel disease, Telemedicine, Infor-mation and communication technologies
Abstract

Telemedicine (TM) has had a powerful impact in recent years, particularly on managing chronic diseases such as inflammatory bowel disease (IBD). Knowing patients' expectations and concerns is essential to increase their confidence in this mode of medical care.We interviewed a large cohort of IBD patients enrolled at two Italian tertiary referral centers to investigate their trust in TM.A total of 376 patients completed the survey and were included in the study: 293 (77.9%) considered TM valuable for managing their disease, and 307 (85%) wanted to have TM service at their center. However, only 99 patients (26.3%) believed that TM guarantees the same level of care as the in-person visit. Among the socio-demographic variables, those independently associated with trust in TM were the higher education qualification (p=0.02) and the level of competence in information and communication technologies (ICT) (p=0.03).Our findings highlighted the importance of equipping IBD patients with basic ICT skills to utilize TM services and increase their confidence in ICT with the help of caregivers. Additionally, to improve the perceived value of TM, it will be helpful to use additional tools such as telemonitoring of disease activity using patients' reported outcomes or remote measurement of fecal calprotectin.

Published
2022

21. Polymorphic variants involved in methylation regulation: a new strategy to discover risk loci for pancreatic ductal adenocarcinoma

Author

Corradi, Chiara, primary, Lencioni, G., additional, Gentiluomo, M., additional, Latiano, A., additional, Kiudelis, G., additional, van Eijck, C., additional, Marta, K., additional, Lawlor, R., additional, Tavano, F., additional, Boggi, U., additional, Dijk, F., additional, Cavestro, G., additional, Vermeulen, R., additional, Hackert, T., additional, Petrone, M., additional, Uzunoglu, F., additional, Archibugi, L., additional, Izbicki, J., additional, Mesquita, B. Bueno-de-, additional, Morelli, L., additional, Zerbi, A., additional, Stocker, H., additional, Talar-Wojnarowska, R., additional, Di Franco, G., additional, Hegyi, P., additional, Sperti, C., additional, Carrara, S., additional, Capurso, G., additional, Gazouli, M., additional, Brenner, H., additional, Bunduc, S., additional, Busch, O., additional, Landi, S., additional, Perri, F., additional, Oliverius, M., additional, Goetz, M., additional, Scognamiglio, P., additional, Mambrini, A., additional, Arcidiacono, P., additional, Kreivenaite, E., additional, Kupcinskas, J., additional, Hussein, T., additional, Ermini, S., additional, Milanetto, A., additional, Vodicka, P., additional, Kiudelis, V., additional, Hlavac, V., additional, Soucek, P., additional, Theodoropoulos, G., additional, Basso, D., additional, Aoki, M., additional, Pezzilli, R., additional, Pasquali, C., additional, Chammas, R., additional, Testoni, S., additional, Mohelníková-Duchoňová, B., additional, Lucchesi, M., additional, Neoptolemos, J., additional, Canzian, F., additional, and Campa, D., additional

Published
2022
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22. Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians

Author

Gentiluomo, Manuel, primary, Piccardi, M., additional, Bertoncini, S., additional, Costello, E., additional, Morelli, L., additional, Landi, S., additional, Milanetto, A., additional, Schöttker, B., additional, Di Franco, G., additional, Ermini, S., additional, Scarpa, A., additional, Izbicki, J., additional, Pezzilli, R., additional, Uzunoglu, F., additional, Talar-Wojnarowska, R., additional, Goetz, M., additional, Lawlor, R., additional, Aoki, M., additional, Bueno-de-Mesquita, B., additional, Busch, O., additional, Chammas, R., additional, Tavano, F., additional, van Laarhoven, H., additional, Cavestro, G., additional, Stocker, H., additional, Bazzocchi, F., additional, Pasquali, C., additional, Chen, X., additional, Puzzono, M., additional, Ponz de Leon Pisani, R., additional, Sperti, C., additional, Lovecek, M., additional, Erőss, B., additional, Basso, D., additional, Kupcinskas, J., additional, Vanagas, T., additional, Janciauskas, D., additional, Poskiene, L., additional, Tacelli, M., additional, Duchonova, B. Mohelnikova, additional, Perri, F., additional, Latiano, A., additional, Mambrini, A., additional, Maiello, E., additional, Hegyi, P., additional, Szentesi, A., additional, Bunduc, S., additional, Hussein, T., additional, Arcidiacono, P., additional, Boggi, U., additional, Hackert, T., additional, Soucek, P., additional, Lucchesi, M., additional, Ginocchi, L., additional, Gazouli, M., additional, Zerbi, A., additional, Roth, S., additional, Jamroziak, K., additional, Carrara, S., additional, Hlavac, V., additional, Oliverius, M., additional, Neoptolemos, J., additional, Theodoropoulos, G., additional, van Eijck, C., additional, Dannemann, M., additional, Canzian, F., additional, Tofanelli, S., additional, and Campa, D., additional

Published
2022
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23. Polymorphisms in Transcription Factor Binding Sites and Enhancers as Pancreatic Ductal Adenocarcinoma Risk Factors

Author

Unal, Pelin, primary, Lu, Y., additional, Aoki, M., additional, Chammas, R., additional, Gazouli, M., additional, Theodoropoulos, G., additional, van Eijck, C., additional, Bijlsma, M., additional, Dijk, F., additional, Bueno-de-Mesquita, B., additional, Kupcinskas, J., additional, Kiudelis, V., additional, Kreivenaite, E., additional, Kondrackiene, J., additional, Malecka-Wojciesko, E., additional, Talar-Wojnarowska, R., additional, Kapszewicz, M., additional, Hegyi, P., additional, Szentesi, A., additional, Eross, B., additional, Bunduc, S., additional, Mohelnikova-Duchonova, B., additional, Soucek, P., additional, Hlavac, V., additional, Oliverius, M., additional, Vodickova, L., additional, Cervena, K., additional, Hackert, T., additional, Neoptolemos, J., additional, Goetz, M., additional, Uzunoglu, F., additional, Izbicki, J., additional, Stocker, H., additional, Schöttker, B., additional, Brenner, H., additional, Perri, F., additional, Tavano, F., additional, Palmieri, O., additional, Bazzocchi, F., additional, Maiello, E., additional, Testoni, S., additional, Petrone, M., additional, Arcidiacono, P., additional, Landi, S., additional, Ermini, S., additional, Bambi, F., additional, Boggi, U., additional, Capurso, G., additional, Archibugi, L., additional, Vanella, G., additional, Cavestro, G., additional, Morelli, L., additional, Di Franco, G., additional, Milanetto, A., additional, Sperti, C., additional, Pasquali, C., additional, Basso, D., additional, Pezzilli, R., additional, Lawlor, R., additional, Capretti, G., additional, Carrara, S., additional, Campa, D., additional, and Canzian, F., additional

Published
2022
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27. Electrochemotherapy as palliative treatment in patients with recurrent and/or metastatic head and neck tumours: features analysis for an early determination of the partial responsive patients

Author

Maglitto, F., Salzano, G., Longo, F., DI BERNARDO, E., D’Alessio, V., Fusco, R., Aversa, C., Pavone, E., Pontone, M., Marciano, M. L., Togo, G., DE FAZIO, G. R., Ordano, D., Maglione, M. G., Vaira, L. A., Bergonzani, M., Salzano, F. A., Maiolino, P., Califano1, L., Ionna, F., and Perri, F.

Subjects
Bleomycin, Skin Neoplasms, Treatment Outcome, Head and Neck Neoplasms, Electrochemotherapy, Palliative Care, Quality of Life, Humans, Pain
Abstract

The aim of this study was to identify features mainly involved in determining the partial response (PR) to the Electrochemotherapy (ECT) in patients with recurrent and/or metastatic head and neck (HN) tumor; the identified features were also used in a decision chart in order to provide the clinician with a support tool in deciding further therapies.131 patients (186 treatment sessions) with recurrent and/or metastatic HN neoplasm were subjected to ECT. Treatment response was evaluated based on Response Evaluation Criteria in Solid Tumors (RECIST) v. 1.1 two months after the ECT. The grade of bleeding and pain before, at the end and one week after ECT treatment were evaluated. Univariate and multivariate analysis were performed to identify features involved in determining the patient PR.In the context of the univariate analysis, tumor size significantly influenced the response to ECT, with higher PR rate of 58.3%: 28 among 48 patients with lesion size ≤ 3 centimeters (p-value0.001 at Chi-square test). Pain and bleeding pre-treatment were positively correlated to PR (p-value0.001 at Chi-square test). A difference in the current flowing in the tissue during treatment was also observed in partially responsive patients, where the median current value (6.6 A) was higher than that achieved in patients that did not show PR (3.3 A). In the context of the multivariate analysis, the best performances are achieved with the BART method (accuracy of 84%). The main clinical factors to predict the partial response, among investigated features, that have shown to be considered were the pain value felt before performing the treatment and the median current delivered during the ECT treatment. A decision-making support tool to predict the patient prognosis in terms of response rate could be represented by the decision tree obtained with CART algorithm, where a pain pre-treatment more than 5 and a median delivered current not less than 2.8 A led to the prediction a partial responsive patient with an accuracy of 75%.The study confirmed that ECT is an interesting antitumoral therapy in advanced chemo- and radio-refractory HN neoplasms, able to reduce frequent symptoms and to improve the quality of life. Pain pre-treatment and delivered current are the most important variables when predicting the partial response of patients.

Published
2022

31. OC.12.1 ACCURACY OF ULTRASONOGRAPHY IN ASSESSING DISEASE ACTIVITY IN PEDIATRIC ULCERATIVE COLITIS: PRELIMINARY RESULTS OF A TWO-CENTER STUDY

Author

Terracciano, F., primary, Marra, A., additional, Bossa, F., additional, Dirodi, A., additional, Ippolito, M.A., additional, Carparelli, S., additional, Pastore, M.R., additional, Valvano, M.R., additional, Marseglia, A., additional, D’Altilia, M., additional, Ferrara, D., additional, Bucci, C., additional, Esposito, F., additional, and Perri, F., additional

Published
2022
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34. Management of Ewing Sarcoma Family of Tumors: A Short Description of a Rare Primitive Uterine pPNET and Literature Review

Author

Pisconti S, Della Vittoria Scarpati G, Buonerba C, Messinese S, Carella R, Di Marzo M, Di Lorenzo G, Lazzari G, Perri F, and Solla R

Subjects
pnet, ppnet, genetics, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, ewing sarcoma
Abstract

Salvatore Pisconti,1 Giuseppina Della Vittoria Scarpati,2 Carlo Buonerba,3 Simona Messinese,1 Roberta Carella,1 Massimiliano Di Marzo,4 Giuseppe Di Lorenzo,3 Grazia Lazzari,5 Francesco Perri,6 Raffaele Solla7,8 1Medical Oncology Unit, POC, SS Annunziata, Taranto, Italy; 2Medical Oncology Unit, Pollena Trocchia Hospital, ASL NA3sud, Naples, Italy; 3Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy; 4Department of Abdominal Surgery, National Tumor Institute of Naples IRCCS G. Pascale, Naples, Italy; 5Department of Radiation Oncology, POC, SS Annunziata, Taranto, Italy; 6Head and Neck Medical Oncology Unit, National Tumor Institute of Naples IRCCS G. Pascale, Naples, Italy; 7Department of Radiation Oncology, University of Naples Federico II, Naples, Italy; 8Italian National Research Council, Institute of Biostructure & Bioimaging, Naples, ItalyCorrespondence: Francesco PerriHead and Neck Medical Oncology Unit, National Tumor Institute of Naples IRCCS G. Pascale, Via Mariano Semmola, Naples 80131, ItalyTel +390815903362Email francescoperri508@gmail.comPurpose: To describe the outcome of a patient with a rare primitive uterine pPNET and to perform a review of the available data in literature, leading the clinicians to better face this rare disease.Methods: We have rescued data regarding the multidisciplinary treatment of pPNET from the PUBMED database, highlighting also issues regarding the pathogenesis and the genetic landscape of the ESFTs (Ewing Sarcoma Family of Tumors).Results: Ewing sarcoma and primitive neuroectodermal tumors (PNETs) are small round cell tumors presenting with different degrees of neuroectodermal differentiation. PNETs are further divided into central PNET and peripheral PNET (pPNET). Since pPNETs share the same genetic background of Ewing Sarcomas, they are considered to belong to the Ewing Sarcoma Family of Tumors (ESFTs). Multimodality treatment currently represents the best choice to offer to the affected patients.Conclusion: Although pPNETs are generally diagnosed in children and young adults, an elderly woman aged 85 years came to our attention after a diagnosis of uterine pPNET. Her medical history is presented here, along with a literature review of the subject, highlighting the main biological, pathological and clinical features, with a hypothesis about the possible future therapeutic approaches for these rare malignancies.Keywords: PNET, pPNET, Ewing Sarcoma, genetics

Published
2020

35. Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians

Author

Gentiluomo, M. Piccardi M., Bertoncini, S., Costello, E., Morelli, L., Landi, S., Milanetto, A. C., Schöttker, B., Di Franco, G., Ermini, S., Scarpa, A., Izbicki, J., Pezzilli, R., Uzunoglu, F., Talar-Wojnarowska, R., Goetz, M., Lawlor, R., Aoki, M., Bueno-de-Mesquita, B., Busch, O., Chammas, R., Tavano, F., van Laarhoven, H., Cavestro, G., Stocker, H., Bazzocchi, F., Pasquali, C., Chen, X., Puzzono, M., Ponz de Leon Pisani, R., Brenner, H., Vodickova, L., Sperti, C., Lovecek, L., Erőss, B., Basso, D., Kupcinskas, J., Vanagas, T., Janciauskas, D., Poskiene, L., Tacelli, M., Mohelnikova Duchonova, B., Capurso, G., Perri, F., Latiano, A., Mambrini, A., Maiello, E., Hegyi, P., Szentesi, A., Bunduc, S., Hussein, T., Arcidiacono, P., Boggi, U., Hackert, T., Archibugi, L., Soucek, P., Vanella, G., Lucchesi, M., Ginocchi, L., Gazouli, M., Zerbi, A., Roth, S., Jamroziak, K., Carrara, S., Hlavac, V., Oliverius, M., Neoptolemos, J., Theodoropoulos, G., van Eijck, C., Dannemann, M., Canzian, F., Tofanelli, S., and Campa, D.

Published
2022

37. Polymorphisms in transcription factor binding sites and enhancers as pancreatic ductal adenocarcinoma risk factors

Author

Unal, P., Lu, Y., Aoki, M., Chammas, R., Gazouli, M., Theodoropoulos, G., van Eijck, C., Bijlsma, M., Dijk, F., Bueno-de-Mesquita, B., Kupcinskas, J., Kiudelis, V., Kreivenaite, E., Kondrackiene, J., Malecka-Wojciesko, E., Talar-Wojnarowska, R., Kapszewicz, M., Hegyi, P., Szentesi, A., Eross, B., Bunduc, S., Mohelnikova-Duchonova, B., Soucek, P., Hlavac, V., Oliverius, M., Vodickova, L., Cervena, K., Hackert, T., Neoptolemos, J., Goetz, M., Uzunoglu, F., Izbicki, J., Stocker, H., Schöttker, B., Brenner, H., Perri, F., Tavano, F., Palmieri, O., Bazzocchi, F., Maiello, E., Testoni, S., Petrone, M., Arcidiacono, P., Landi, S., Ermini, S., Bambi, F., Boggi, U., Capurso, G., Archibugi, L., Vanella, G., Cavestro, G., Morelli, L., Di Franco, G., Milanetto, A. C., Sperti, C., Pasquali, C., Basso, D., Pezzilli, R., Lawlor, R., Capretti, G., Carrara, S., Campa, D., and Canzian, F.

Subjects
Hepatology, Endocrinology, Diabetes and Metabolism, Gastroenterology
Published
2022

39. P693 Willingness and hesitancy to the telemedicine in patients with inflammatory bowel disease during COVID-19 outbreak. Preliminary results of a survey in an Italian IBD Center

Author

Bossa, F, primary, Guerra, M, additional, Carparelli, S, additional, Antonella, M, additional, Terracciano, F, additional, Costantino, A, additional, Caprioli, F, additional, Valvano, M R, additional, Martino, G, additional, Nardella, M, additional, and Perri, F, additional

Published
2022
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40. P218 Accuracy of Ultrasonography in Assessing Disease Activity in Pediatric Ulcerative Colitis: Preliminary Results of a two-center study

Author

Marra, A, primary, Terracciano, F, additional, Bossa, F, additional, Pastore, M R, additional, Marseglia, A, additional, Di Rodi, A, additional, Valvano, M R, additional, Carparelli, S, additional, Ippolito, M A, additional, D’Altilia, M, additional, Ferrara, D, additional, Esposito, F, additional, Bucci, C, additional, and Perri, F, additional

Published
2022
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43. 'Regional' Gastrectomy

Author

Di Matteo, G., Lucci, S., Cancrini, A., Jr, Palazzini, G., Boemi, L., Perri, F. A., Reed, Peter I., editor, Carboni, Manlio, editor, Johnston, Belinda J., editor, and Guadagni, Stefano, editor

Published
1990
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44. 862MO Gene expression profile differentiates short-term and long-term survivors with immunotherapy in patients with recurrent/metastatic head and neck cancer

Author

Bossi, P., primary, Gurizzan, C., additional, Airoldi, M., additional, Cossu Rocca, M., additional, Strojan, P., additional, Cvetka, G.K., additional, Merlano, M.C., additional, Denaro, N., additional, Caponigro, F., additional, Perri, F., additional, Argiris, A., additional, Licitra, L.F., additional, Serafini, M.S., additional, and De Cecco, L., additional

Published
2021
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47. P623 The impact of SARS-CoV-2 outbreak on the treatment adherence and clinical outcome of patients with inflammatory bowel disease treated with biological agents

Author

Martino, G, primary, Carparelli, S, additional, Marseglia, A, additional, Pastore, M R, additional, Placentino, M, additional, Nardella, M, additional, Guerra, M, additional, Palmieri, O, additional, Latiano, A, additional, Perri, F, additional, Ercolino, F, additional, and Bossa, F, additional

Published
2021
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48. Accuracy and Inter-Observer Agreement of the Nice and the Kudo Classifications of Superficial Colonic Lesions: A Comparative Study

Author

Cocomazzi, F, additional, Gentile, M, additional, Perri, F, additional, Bossa, F, additional, Merla, A, additional, Ippolito, A, additional, Cubisino, R, additional, Carparelli, S, additional, Marra, A, additional, Mileti, A, additional, Paolillo, R, additional, Piazzolla, M, additional, Copetti, M, additional, Parente, P, additional, Graziano, P, additional, Di Leo, A, additional, and Andriulli, A, additional

Published
2021
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49. Inter-Observer Agreement of the Paris and the Simplified Classifications of Superficial Colonic Lesions: A Western Study

Author

Cocomazzi, F, additional, Gentile, M, additional, Perri, F, additional, Merla, A, additional, Bossa, F, additional, Piazzolla, M, additional, Ippolito, A, additional, Terracciano, F, additional, Giuliani, AP, additional, Cubisino, R, additional, Marra, A, additional, Carparelli, S, additional, Mileti, A, additional, Paolillo, R, additional, Fontana, A, additional, Copetti, M, additional, Di, Leo A, additional, and Andriulli, A, additional

Published
2021
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