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4. TACE and conformal radiotherapy vs. TACE alone for hepatocellular carcinoma: A randomised controlled trial

Author

Féray, Cyrille, Campion, Loic, Mathurin, Philippe, Archambreaud, Isabelle, Mirabel, Xavier, Bronowicki, Jean Pierre, Rio, Emmanuel, Perret, Christophe, Mineur, Laurent, Oberti, Frédéric, Touchefeu, Yann, Gournay, Jérôme, Regnault, Hélène, Edeline, Julien, Rode, Agnès, Hillion, Patrick, Blanc, Jean Frédéric, Khac, Eric Nguyen, Azoulay, Daniel, Luciani, Alain, Preglisasco, Athena Galetto, Faurel-Paul, Elodie, Auble, Hélène, Mornex, Françoise, and Merle, Philippe

Published
2023
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5. Pulmonary Artery Embolization in the Management of Hemoptysis Related to Lung Tumors

Author

Claudinot, Amandine, primary, Douane, Frédéric, additional, Morla, Olivier, additional, Perret, Christophe, additional, Neveu, Marine, additional, Thouveny, Francine, additional, Bouvier, Antoine, additional, Hureaux, José, additional, Le Guen, Arnaud, additional, Jouan, Jérémy, additional, Heautot, Jean-François, additional, Larralde, Antoine, additional, Cerasuolo, Damiano, additional, Bergot, Emmanuel, additional, Fohlen, Audrey, additional, and Pelage, Jean-Pierre, additional

Published
2023
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10. Utilisation des modèles pharmacocinétiques et pharmacodynamiques dans le développement des candidats médicaments

Author

Perret, Christophe, Aix-Marseille Université - Faculté de pharmacie (AMU PHARM), Aix Marseille Université (AMU), and Florence Gattacceca

Subjects
Modélisation, [SDV]Life Sciences [q-bio], Modèle pharmacocinétique physiologique (PBPK), Pré-clinique, Prédiction, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, Candidats-médicaments, Développement
Abstract

Introduction : les simulations sont utilisées pour prédire le comportement d’un élément depuis des décennies, et tout particulièrement dans le monde pharmaceutique. Cette méthode permet de gagner du temps et de l’argent pour les industriels. Dans le cadre de cette thèse, l’utilisation des modèles pharmacocinétiques et pharmacodynamiques aidant au développement des candidats-médicaments seront mis en avant. La détermination de la première dose à administrer à l’Homme à partir des résultats précliniques a été l’objectif principal de recherche.Matériels et Méthodes : pour la conception du projet, les études sur la molécule A ont été menées sur trois espèces : le rat ; le chien et le singe. De plus des études in vitro ont été réalisées afin de mieux comprendre les mécanismes et les interactions des molécules A et B. Des modèles sur ordinateurs utilisant les logiciels Excel, Gastroplus et Berkeley Madonna ont été utilisés pour prédire le comportement du candidat-médicament chez l’Homme.Résultats : les comportements pharmacocinétiques et pharmacodynamiques de la molécule A ont pu être déterminés avant la première administration à l’Homme grâce aux résultats in vivo et in vitro.Conclusion et Discussion : les résultats mis en avant durant les études sur la molécule A et la molécule B ne sont que des suppositions et nécessitent d’être confirmés par des études chez l’Homme. Cependant, elles montrent le processus qui est réalisé par les chercheurs dans l’industrie pharmaceutique afin de diminuer les coûts et d’accélérer la productivité dans la recherche.

Published
2021

13. Results from the phase I dose-escalation study of the radiation enhancer NBTXR3 for the treatment of HCC and liver metastases.

Author

De Baere, Thierry, primary, Pracht, Marc, additional, Rolland, Yann, additional, Durand-Labrunie, Jerome, additional, Jaksic, Nicolas, additional, Nguyen, France, additional, Bronowicki, Jean-Pierre, additional, Vendrely, Veronique, additional, Croisé-Laurent, Valérie, additional, Rio, Emmanuel, additional, Le Sourd, Samuel, additional, Said, Patricia, additional, Gustin, Pierre, additional, Perret, Christophe, additional, Peiffert, Didier, additional, Deutsch, Eric, additional, and Chajon, Enrique, additional

Published
2021
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14. Pharmaco-mechanical catheter-directed thrombolysis versus recanalization and stenting for post thrombotic syndrome after lower limb deep vein thrombosis: a comparative study

Author

Gautier, Giovanni, primary, Douane, Frederic, additional, David, Arthur, additional, Perret, Christophe, additional, Pistorius, Marc-Antoine, additional, Goueffic, Yann, additional, Connault, Jerôme, additional, Artifoni, Mathieu, additional, Durant, Cecile, additional, Ploton, Gaëtan, additional, Raimbeau, Alizee, additional, Bergere, Guillaume, additional, Robin, Olivier, additional, Maurel, Blandine, additional, and Espitia, Olivier, additional

Published
2021
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17. Treatment of hepatocellular carcinoma and liver metastases with hafnium oxide nanoparticles activated by SBRT: A phase I/II trial.

Author

Jaksic, Nicolas, primary, Pracht, Marc, additional, Rolland, Yann, additional, De Baere, Thierry, additional, Durand-Labrunie, Jerome, additional, Nguyen, France, additional, Bronowicki, Jean-Pierre, additional, Vendrely, Veronique, additional, Sa Cunha, Antonio, additional, Croisé-Laurent, Valérie, additional, Rio, Emmanuel, additional, Le Sourd, Samuel, additional, Said, Patricia, additional, Freund, Sebastian, additional, Baskin-Bey, Edwina, additional, Gustin, Pierre, additional, Perret, Christophe, additional, Peiffert, Didier, additional, Deutsch, Eric, additional, and Chajon, Enrique, additional

Published
2020
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19. First-in-class hafnium oxide nanoparticles NBTXR3 in the treatment of liver cancers.

Author

Chajon, Enrique, primary, Pracht, Marc, additional, Rolland, Yan, additional, De Baere, Thierry, additional, Nguyen, France, additional, Bronowicki, Jean-Pierre, additional, Vendrely, Veronique, additional, Sa Cunha, Antonio, additional, Baumann, Anne-Sophie, additional, Valérie, Laurent, additional, Rio, Emmanuel, additional, Le Sourd, Samuel, additional, Gustin, Pierre, additional, Perret, Christophe, additional, Peiffert, Didier, additional, and Deutsch, Eric, additional

Published
2019
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20. Hepatocellular carcinoma and liver metastasis treated by hafnium oxide nanoparticles activated by SBRT: A phase I/II trial.

Author

Chajon, Enrique, primary, Pracht, Marc, additional, De Baere, Thierry, additional, Nguyen, France, additional, Bronowicki, Jean-Pierre, additional, Vendrely, Veronique, additional, Baumann, Anne-Sophie, additional, Valérie, Laurent, additional, Rio, Emmanuel, additional, Rolland, Yan, additional, Le Sourd, Samuel, additional, Gustin, Pierre, additional, Perret, Christophe, additional, Mornex, Francoise, additional, Peiffert, Didier, additional, Merle, Philippe, additional, and Deutsch, Eric, additional

Published
2019
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21. Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study

Author

Gagniere, Johan, Abjean, Adeline, Franz, Martin, Aumont, Ophélie, Pereira, Bruno, Dupré, Aurélien, Veziant, Julie, Le Roy, Bertrand, Pezet, Denis, Buc, Emmanuel, Maran, Jean-Christophe, Cassagnes, Lucie, Musset, Dominique, Frydman, René, Mage, Gérard, Canis, Michel, Ami, Olivier, Nicolas, Charlotte, Le Gouge, Amélie, D’Alteroche, Louis, Ayoub, Jean, Georgescu, Monica, Vidal, Vincent, Castaing, Denis, Cercueil, Jean, Chevallier, Patrick, Roumy, Jerome, Trillaud, Hervé, Boyer, Louis, Le Pennec, Vincent, Perret, Christophe, Giraudeau, Bruno, Perarnau, Jean, Service Chirurgie Disgestive, CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), Service d'Oncologie Chirurgicale [Lyon], Centre Léon Bérard [Lyon], Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), CHU Clermont-Ferrand, Service Chirurgie Digestive, Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Gabriel Montpied [Clermont-Ferrand], Service de radiologie et imagerie [Béclère], AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11), Service de gynécologie-obstétrique, médecine de la reproduction [Béclère], Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CIC - Tours, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Service de chirurgie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse, Centre Hospitalier Universitaire de Nice (CHU Nice), Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques ( IRTOMIT), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Saint-André, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Inserm CIC 202, France, François Rabelais University Tours, France, Tours University Hospital, France, Institut National de la Santé et de la Recherche Médicale (INSERM), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire Estaing, Biostat Unit, Centre Hospitalier Universitaire de Clermont-Ferrand, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte - Clermont Auvergne (M2iSH), Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), Institut Pascal - Clermont Auvergne (IP), Sigma CLERMONT (Sigma CLERMONT)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), CHU Gabriel Montpied (CHU), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Antoine Béclère, and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse

Subjects
medicine.medical_specialty, Hepatology, business.industry, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Transjugular intrahepatic portosystemic shunt, 030218 nuclear medicine & medical imaging, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Dysfunction, cardiovascular system, medicine, Prospective Study, 030211 gastroenterology & hepatology, Radiology, Ultrasonography, Doppler-ultrasonography, business, Prospective cohort study, ComputingMilieux_MISCELLANEOUS, circulatory and respiratory physiology
Abstract

AIM To prospectively evaluate the performance of Doppler-ultrasonography (US) for the detection of transjugular intrahepatic portosystemic shunt (TIPS) dysfunction within a multicenter cohort of cirrhotic patients. METHODS This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction (defined by a portosystemic gradient ≥ 12 mmHg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of Tours. RESULTS Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein (P = 0.008), the reversal of flow in the right (P = 0.038) and left (P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium (P = 0.0005), ascites (P = 0.001) and the overall impression of the operator (P = 0.0001). The diagnostic performances of these variables were low; sensitivity was < 58% and negative predictive value was < 73%. Therefore, dysfunction cannot be ruled out from Doppler-US. CONCLUSION The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction.

Published
2017

22. NBTXR3, hafnium oxide nanoparticles in the treatment of liver cancer: A phase I/II trial.

Author

Chajon, Enrique, primary, Pracht, Marc, additional, De Baere, Thierry, additional, Nguyen, France, additional, Bronowicki, Jean-Pierre, additional, Vendrely, Veronique, additional, Baumann, Anne-Sophie, additional, Croisé-Laurent, Valérie, additional, Rio, Emmanuel, additional, Rolland, Yan, additional, Le Sourd, Samuel, additional, Gustin, Pierre, additional, Perret, Christophe, additional, Mornex, Francoise, additional, Peiffert, Didier, additional, Merle, Philippe, additional, and Deutsch, Eric, additional

Published
2018
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24. Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study

Author

Nicolas, Charlotte, primary, Le Gouge, Amélie, additional, d’Alteroche, Louis, additional, Ayoub, Jean, additional, Georgescu, Monica, additional, Vidal, Vincent, additional, Castaing, Denis, additional, Cercueil, Jean-Pierre, additional, Chevallier, Patrick, additional, Roumy, Jérôme, additional, Trillaud, Hervé, additional, Boyer, Louis, additional, Le Pennec, Vincent, additional, Perret, Christophe, additional, Giraudeau, Bruno, additional, and Perarnau, Jean-Marc, additional

Published
2017
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25. Plasma cholesterol is excreted in the feces of patients with complete common bile duct obstruction : In vivo evidence for TICE pathway in humans

Author

Moreau, Francois, primary, Blanchard, Claire, additional, Perret, Christophe, additional, Flet, Laurent, additional, Douane, Frédéric, additional, Frampas, Eric, additional, Aguesse, Audrey, additional, Ouguerram, Khadija, additional, Krempf, Michel, additional, Prieur, Xavier, additional, Pichelin, Matthieu, additional, Miraillé, Eric, additional, Cariou, Bertrand, additional, and Le May, Cédric, additional

Published
2017
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27. Cocoa

Author

Bastide, Philippe and Perret, Christophe

Subjects
Analyse de système, Fève de cacao, E14 - Économie et politique du développement, Theobroma cacao, Donnée de production, Commerce international, Marché, E71 - Commerce international, Offre et demande, E16 - Économie de la production, Commercialisation, Qualité
Abstract

West Africa was - conceived - for the most part by the colonizers seeking suppliers of agricultural raw materials. The Office du Niger (initially set up for cotton), the groundnut basins in Senegal and northern Nigeria, cotton basins, rubber tree and oil palm plantations were responsible for shaping the rural landscape, fostering the development of towns, redistributing the population and sometimes even defining borders of future nations states. Cocoa and coffee are emblematic of this history. Often considered inseparable, grown in the same areas, both dependent on the London and New York stock exchanges, subject to speculative global markets, they are two topic-specific chapters of the Atlas on Regional Integration in West Africa.

Published
2007

28. Le cacao

Author

Bastide, Philippe and Perret, Christophe

Subjects
Analyse de système, Fève de cacao, E14 - Économie et politique du développement, Theobroma cacao, Donnée de production, Commerce international, Marché, E71 - Commerce international, Libéralisation des échanges, Offre et demande, E16 - Économie de la production, Commercialisation, Qualité
Abstract

L'Afrique de l'Ouest a été en grande partie "conçue" par les colonisateurs pour ses fonctions de pourvoyeuse de matières premières agricoles. L'Office du Niger (dont la fonction initiale était le coton), le bassin arachidier du Sénégal, celui du Nord Nigeria, les bassins cotonniers, les plantations d'hévéas et de palmier à huile, ont modelé les paysages agraires, fait naître des villes, recomposé le peuplement et parfois même défini les frontières des futurs Etats nations. Le cacao et le café sont emblématiques de cette histoire. Souvent considérés comme indissociables, cultivés dans les mêmes zones, dépendant l'un et l'autre des bourses de New York et de Londres, soumis à des marchés mondiaux spéculatifs, ils font pourtant l'objet de deux chapitres distincts de l'Atlas de l'intégration régionale en Afrique de l'Ouest.

Published
2007

34. Cotton in West Africa

Author

Hussein, Karim, Perret, Christophe, Hitimana, Leonidas, Organisation for Economic Co-operation and Development, Hussein, Karim, Perret, Christophe, Hitimana, Leonidas, and Organisation for Economic Co-operation and Development

Subjects
Cotton growing--Government policy--Africa, West, Cotton--Africa, West--Cultural policy, Cotton trade--Africa, West, Cotton trade--Government policy--Africa, West, Cotton growing--Africa, West
Abstract

In West Africa, approximately 16 million people depend directly or indirectly on cotton cultivation. Cotton plays a vital role in the economic and social development of many countries, and in improving the livelihoods of the inhabitants. It has also enabled West Africa to become a major player on the international market, since it is now the second largest fiber exporter behind the United States. This success is partly due to an integrated approach which is often called the'cotton system.'Since the World Trade Organization's 2003 Ministerial Conference in Cancun, the actors in the international community have recognized the crucial need to address the cotton crisis in an'ambitious, rapid and specific'manner. At the end of the Hong Kong Ministerial Conference in December 2005, progress was made in the negotiations aiming to reduce subsidies, ensure market access and improve development policies. On 24 July, multilateral trade negotiations of the Doha'Development Round'were suspended because an agreement could not be reached which would satisfy both developing and developed countries. This book contends that dialogue between developed and developing countries should continue in order to find a lasting solution to the difficulties facing the cotton sub-sector. It sets out the regional stakes linked to the economic and social importance of cotton in West Africa. It retraces the consultation process on the West African cotton crisis with the aim of finding a negotiated solution acceptable to all parties. Also discussed are the challenges and the measures that need to be taken over the medium and long term in order to prevent this sub-sector's sudden collapse. Countries covered: Benin, Burkina Faso, Cameroon, Cape Verde, Chad, Côte d'Ivoire, The Gambia, Ghana, Guinea, Guinea-Bissau, Liberia, Mali, Mauritania, Niger, Nigeria, Senegal, Sierra Leone, and Togo.--Publisher summary.

Published
2006

36. Revitalisation de la zone humide de La Presta.

Author

Blant, Jean-Daniel, Matthey, Yvan, and Perret, Christophe

Subjects
WETLANDS, BIRD watching, BIRD watchers, BIRDS, ORNITHOLOGY
Abstract

The article offers information on the revitalization of the wetland of La Presta by the PAONNE committee for bird watching in France in 2019. Topics discussed include the waterbodies of that area, and their suitability for the availability of various birds for bird watchers. It also mentions about the renovations made by the PAONNE committee to improve their conditions.

Published
2019

37. Tracking the dynamic interplay between bacterial and host factors during pathogen-induced vacuole rupture in real time

Author

Anne Danckaert, Katrina Ray, Jost Enninga, Philippe J. Sansonetti, Guy Tran Van Nhieu, Alexandre Bobard, Caroline Clair, Irit Paz-Haftel, Soudeh Ehsani, Christoph M. Tang, Dynamique des Interactions Hôte-Pathogène - Dynamics of Host-Pathogen Interactions, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Pathogénie Microbienne Moléculaire, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Imperial College London, Microbiology and Systems Biology Department, The Netherlands Organisation for Applied Scientific Research (TNO), Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université - Faculté de Médecine (SU FM), Sorbonne Université (SU), Chaire Microbiologie et Maladies infectieuses, Collège de France (CdF (institution)), Katrina Ray is supported by the EIMID programme, and Jost Enninga acknowledges the support from the International Human Frontiers Science Program Organisation (HFSPO). This study was also supported by the ANR (grant: MIE NR. A05134JS to Philippe Sansonetti)., The authors would like to thank the members of the laboratories of P.S., J.E., and C.T. for stimulating discussions on various aspects of this work. Furthermore, we would like to thank Emmanuelle Perret, Christophe Machu and Pascale Roux at the PFID at the Institut Pasteur with help setting up the automated microscopy. We also appreciate the work of Adeline Mallet from the PFMU at the Institut Pasteur for performing the electron microscope analysis. We would like to thank Stéphane Meresse (Luminy, Marseille) and Roger Tsien (San Diego) for contributing plasmids., Dynamique des Interactions Hôte-Pathogène, Institut Pasteur [Paris], Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Collège de France - Chaire Microbiologie et Maladies infectieuses

Subjects
Time Factors, RHOA, MESH: Shigella flexneri, Galectin 3, Immunology, MESH: Glycoproteins, Vacuole, Microbiology, MESH: Vacuoles, Shigella flexneri, 03 medical and health sciences, Bacterial Proteins, Salmonella, Virology, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Humans, MESH: Salmonella, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Pathogen, MESH: Bacterial Proteins, Glycoproteins, 030304 developmental biology, 0303 health sciences, Host cell cytosol, MESH: Humans, biology, 030306 microbiology, Effector, MESH: Host-Pathogen Interactions, MESH: Time Factors, biology.organism_classification, MESH: Galectin 3, Cell biology, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], Cytosol, Host-Pathogen Interactions, Vacuoles, MESH: HeLa Cells, biology.protein, Bacteria, HeLa Cells
Abstract

International audience; Escape into the host cell cytosol following invasion of mammalian cells is a common strategy used by invasive pathogens. This requires membrane rupture of the vesicular or vacuolar compartment formed around the bacteria after uptake into the host cell. The mechanism of pathogen-induced disassembly of the vacuolar membrane is poorly understood. We established a novel, robust and sensitive fluorescence microscopy method that tracks the precise time point of vacuole rupture upon uptake of Gram-negative bacteria. This revealed that the enteroinvasive pathogen Shigella flexneri escapes rapidly, in less than 10 min, from the vacuole. Our method demonstrated the recruitment of host factors, such as RhoA, to the bacterial entry site and their continued presence at the point of vacuole rupture. We found a novel host marker for ruptured vacuoles, galectin-3, which appears instantly in the proximity of bacteria after escape into the cytosol. Furthermore, we show that the Salmonella effector proteins, SifA and PipB2, stabilize the vacuole membrane inhibiting bacterial escape from the vacuole. Our novel approach to track vacuole rupture is ideally suited for high-content and high-throughput approaches to identify the molecular and cellular mechanisms of membrane rupture during invasion by pathogens such as viruses, bacteria and parasites.

Published
2016

38. Pharmaco-mechanical catheter-directed thrombolysis versus recanalization and stenting for post thrombotic syndrome after lower limb deep vein thrombosis: a comparative study.

Author

Gautier G, Douane F, David A, Perret C, Pistorius MA, Goueffic Y, Connault J, Artifoni M, Durant C, Ploton G, Raimbeau A, Bergere G, Robin O, Maurel B, and Espitia O

Abstract

Background: Endovenous interventional procedures can be used in addition to therapeutic anticoagulation to treat deep vein thrombosis in selected patients with proximal vein involvement (vena cava, iliac and/or common femoral). The aim of this study was to compare venous patency and the post-thrombotic syndrome (PTS) in patients treated with pharmaco-mechanical catheter-directed thrombolysis (PMT) versus recanalization-stenting for PTS after a proximal lower limb deep vein thrombosis., Methods: Between January 2014 and December 2020, this retrospective and monocentric study included patients with very symptomatic acute iliofemoral deep vein thrombosis treated with PMT within 21 days after diagnosis (PMT group) and patients with PTS caused by chronic venous obstruction treated with recanalization and stenting (CRS group)., Results: A total of 116 patients were included (26 PMT, 90 CRS). The rate of primary patency was 81.8% (18/22 patients) in the PMT group and 78.4% (69/88) in the CRS group (P>0.99). The rate of venous patency at the last follow-up was 76.9% (20/26) in the PMT group and 82.2% (74/90) in the CRS group (P=0.57). The median number of stents was 2 (range, 0-5) in the PMT group and 3 (range, 0-7) in the CRS group (P<0.001). The median stent length was 150 mm (range, 60-390 mm) and 280 mm (range, 120-820 mm), respectively (P<0.001). The median last Villalta score was 2 (range, 0-10) in the PMT group and 2 (range, 0-21) in the CRS group (P=0.55). The rate of venous claudication at the last follow-up was 19.0% (4/21) in the PMT group and 12.0% (10/83) in the CRS group (P=0.47)., Conclusions: In this study, there was no difference in venous patency and in the rate and severity of PTS between the PMT and CRS groups. The number of stent and their length were significantly lower in the PMT group compared with the CRS group., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi.org/10.21037/qims-21-572). FD reports research funding from Cook medical, Optimed, WL Gore and personal fees and grants from Cook medical, Optimed, WL Gore (medical advisory board, educational course, speaking). YG reports research funding from Abbott, General Electric, Veryan, WL Gore and personal fees and grants from Abbott, Bard, Biotronik, Boston Scientic, Cook, General Electric, Medtronic, Penumbra, Terumo, Veryan, WL Gore (medical advisory board, educational course, speaking). BM reports consulting and proctoring fees from COOK medical and consulting fees from Philips Medical. OE reports research funding from Boston Scientific (Industry-Sponsored Research). The other authors have no conflicts of interest to declare., (2022 Quantitative Imaging in Medicine and Surgery. All rights reserved.)

Published
2022
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