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A two‐dimensional numerical analysis based on the finite element method and linear elasticity is used to demonstrate how the differential compaction of the basinal unit can cause the early deformation of a prograding and/or aggrading carbonate platform. Our model investigates the modification of the carbonate platform stratal architecture and stress field driven by the process of differential compaction. We compared the results of our model with observations from two Triassic carbonate platforms in the Italian Dolomites: Lastoni di Formin and Nuvolau Mts. (Passo Giau, Italy). We show that the model can explain the modification of stratal architecture, as well as fault and fracture patterns observed on these platforms. In particular, we show that (1) the slope and slope‐to‐basin transition regions are expected to experience most of the brittle deformation and, differently from what was suggested by previous numerical studies, the formation of platform‐ward dipping faults and major fractures with dip angles that tend to decrease moving dip‐ward. In addition, (2) the inner platform region can exhibit a slightly tensile regime, which may lead to the formation of syndepositional and/or syndiagenetic fractures. Moreover, (3) in the case of predominantly prograding platforms, the results of the model show a general tilting and thickening of the inner platform strata towards the shelf‐slope break. [ABSTRACT FROM AUTHOR]

Extracorporeal Photopheresis (ECP) may be considered the unique large-scale cell therapy currently available. It is currently employed mainly as second-line treatment, especially in steroid-resistant or steroid-dependent Graft versus Host Disease (GvHD) with good results and very few limitations. Many points need to be clarified regarding the ECP mechanism of action, that conditions the lack of uniqueness among the different centers, essentially cycle frequency, treatment duration, and the number of cells to be treated to obtain a response, according to the organs involved. Moreover, reliable biomarkers for prediction of response are lacking, as well as the best pharmacological combination. We will focus on the recent advances concerning ECP for GvHD treatment. We performed a systematic literature research in Pubmed and Embase as of September 2023. The recent studies on ECP mechanism of action along with the promising biomarkers of response, and the synergistic benefit of ECP in association with the new drugs render this therapy an important weapon for GvHD resistant to conventional treatment and can be proposed as a valid first-line therapy option with promising results. We believe that it should be used early in all categories of patients, considering its high safety profile. [ABSTRACT FROM AUTHOR]

The investigation of deformations in Quaternary deposits holds primary importance in understanding recent geological history and natural hazards in highly populated areas, such as the Po Plain. While civil excavations and trenches possess the potential to be pivotal in identifying and characterizing these deformations, they often remain underused due to the stringent regulation framework and timetables governing civil construction works. In this study, we demonstrate how digital photogrammetry and digital outcrop modelling (DOM) are useful techniques for obtaining a permanent digital representation of a trench situated in Castelletto Ticino (Po Plain–Southern Alps transition). This trench exhibits Holocene deformational structures: (i) an overall tilting of sedimentary deposits towards the SW; (ii) folds with a NE–SW trend; (iii) slumping and other soft-sediment deformations structures; and (iv) reverse faults with NE–SW and NW–SE directions. Using radiocarbon and archeological dating, we are able to confidently constrain the age of these deformations to between 8760 and 400 years BC, suggesting recent tectonic activity related to buried thrust faults. [ABSTRACT FROM AUTHOR]

Background: Refractory or metastatic nasopharyngeal carcinoma (NPC) patients have a poor prognosis due to the lack of effective salvage treatments and prolonged survival by means of combination chemotherapy being described only for a minority of younger patients with oligometastatic disease. Targeting the Epstein - Barr virus (EBV) proteins expressed in NPC cells has been shown to be a feasible strategy that could help control systemic disease. Patients and Methods: Between 2011 and 2014, 16 patients with recurrent/metastatic EBV-NPC received first-line chemotherapy (CT) followed by 2 doses of autologous cytotoxic EBV specific T-lymphocytes (15-25 x 107 total cells/dose, 2 weeks apart), based on our previous studies showing the feasibility and efficacy of this infusion regimen. Cumulative overall survival (OS) and median OS were analysed in the whole population and according to specific clinical and biological parameters. Results: All patients received the planned T-cell therapy schedule, 9 after reaching partial (n=5) or complete (n=4) disease remission with CT, and 7 after failing to obtain benefit from chemotherapy. No severe adverse events were recorded. Patients who received cytotoxic T-lymphocytes (CTLs) had a cumulative 10-year OS of 44%, with a median OS of 60 months (95% CI 42-62). Patients responding to CT, with oligometastatic disease (<3 disease sites), and plasma EBV-DNA <1000 copies/mL had a better outcome. Conclusions: Autologous EBV-specific CTLs transplanted following conventional first-line CT demonstrated promising efficacy with several patients obtaining long-lasting disease control. The rationale provided by this study, with the crucial role likely played by the timing of CTL administration when trying to induce synergy with conventional treatment needs to be confirmed in a prospective controlled trial. [ABSTRACT FROM AUTHOR]