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2. Non-Small Cell Lung Cancer Testing on Reference Specimens: An Italian Multicenter Experience

Author

Pepe, Francesco, Russo, Gianluca, Venuta, Alessandro, Scimone, Claudia, Nacchio, Mariantonia, Pisapia, Pasquale, Goteri, Gaia, Barbisan, Francesca, Chiappetta, Caterina, Pernazza, Angelina, Campagna, Domenico, Giordano, Marco, Perrone, Giuseppe, Sabarese, Giovanna, Altimari, Annalisa, de Biase, Dario, Tallini, Giovanni, Calistri, Daniele, Chiadini, Elisa, Capelli, Laura, Santinelli, Alfredo, Gulini, Anna Elisa, Pierpaoli, Elisa, Badiali, Manuela, Murru, Stefania, Murgia, Riccardo, Guerini Rocco, Elena, Venetis, Konstantinos, Fusco, Nicola, Morotti, Denise, Gianatti, Andrea, Furlan, Daniela, Rossi, Giulio, Melocchi, Laura, Russo, Maria, De Luca, Caterina, Palumbo, Lucia, Simonelli, Saverio, Maffè, Antonella, Francia di Celle, Paola, Venesio, Tiziana, Scatolini, Maria, Grosso, Enrico, Orecchia, Sara, Fassan, Matteo, Balistreri, Mariangela, Zulato, Elisabetta, Reghellin, Daniela, Lazzari, Elena, Santacatterina, Maria, Piredda, Maria Liliana, Riccardi, Manuela, Laurino, Licia, Roz, Elena, Longo, Domenico, Romeo, Daniela Petronilla, Fazzari, Carmine, Moreno-Manuel, Andrea, Puglia, Giuseppe Diego, Prjibelski, Andrey D., Shafranskaya, Daria, Righi, Luisella, Listì, Angela, Vitale, Domenico, Iaccarino, Antonino, Malapelle, Umberto, and Troncone, Giancarlo

Published
2024
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4. Robotic versus laparoscopic distal pancreatectomy in obese patients

Author

Ausania, Fabio, Landi, Filippo, Martinie, John B., Vrochides, Dionisios, Walsh, Matthew, Hossain, Shanaz M., White, Steven, Prabakaran, Viswakumar, Melstrom, Laleh G., Fong, Yuman, Butturini, Giovanni, Bignotto, Laura, Valle, Valentina, Bing, Yuntao, Xiu, Dianrong, Di Franco, Gregorio, Sanchez-Bueno, Francisco, de’Angelis, Nicola, Laurent, Alexis, Giuliani, Giuseppe, Pernazza, Graziano, Esposito, Alessandro, Salvia, Roberto, Bazzocchi, Francesca, Esposito, Ludovica, Pietrabissa, Andrea, Pugliese, Luigi, Memeo, Riccardo, Uyama, Ichiro, Uchida, Yuichiro, Rios, José, Coratti, Andrea, Morelli, Luca, and Giulianotti, Pier C.

Published
2023
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5. Conversion to open surgery in obese patients undergoing minimally invasive distal pancreatectomy: results from a multicenter analysis

Author

Ausania, Fabio, Gonzalez-Abós, Carolina, Landi, Filippo, Martinie, John B., Vrochides, Dionisios, Walsh, Matthew, Hossain, Shanaz M., White, Steven, Prabakaran, Viswakumar, Melstrom, Laleh G., Fong, Yuman, Butturini, Giovanni, Bignotto, Laura, Valle, Valentina, Bing, Yuntao, Xiu, Dianrong, Di Franco, Gregorio, Sanchez-Bueno, Francisco, de'Angelis, Nicola, Laurent, Alexis, Giuliani, Giuseppe, Pernazza, Graziano, Esposito, Alessandro, Salvia, Roberto, Bazzocchi, Francesca, Esposito, Ludovica, Pietrabissa, Andrea, Pugliese, Luigi, Memeo, Riccardo, Uyama, Ichiro, Uchida, Yuichiro, Ríos, José, Coratti, Andrea, Morelli, Luca, and Giulianotti, Pier C.

Published
2024
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6. Non-Small Cell Lung Cancer Testing on Reference Specimens: An Italian Multicenter Experience

Author

Francesco Pepe, Gianluca Russo, Alessandro Venuta, Claudia Scimone, Mariantonia Nacchio, Pasquale Pisapia, Gaia Goteri, Francesca Barbisan, Caterina Chiappetta, Angelina Pernazza, Domenico Campagna, Marco Giordano, Giuseppe Perrone, Giovanna Sabarese, Annalisa Altimari, Dario de Biase, Giovanni Tallini, Daniele Calistri, Elisa Chiadini, Laura Capelli, Alfredo Santinelli, Anna Elisa Gulini, Elisa Pierpaoli, Manuela Badiali, Stefania Murru, Riccardo Murgia, Elena Guerini Rocco, Konstantinos Venetis, Nicola Fusco, Denise Morotti, Andrea Gianatti, Daniela Furlan, Giulio Rossi, Laura Melocchi, Maria Russo, Caterina De Luca, Lucia Palumbo, Saverio Simonelli, Antonella Maffè, Paola Francia di Celle, Tiziana Venesio, Maria Scatolini, Enrico Grosso, Sara Orecchia, Matteo Fassan, Mariangela Balistreri, Elisabetta Zulato, Daniela Reghellin, Elena Lazzari, Maria Santacatterina, Maria Liliana Piredda, Manuela Riccardi, Licia Laurino, Elena Roz, Domenico Longo, Daniela Petronilla Romeo, Carmine Fazzari, Andrea Moreno-Manuel, Giuseppe Diego Puglia, Andrey D. Prjibelski, Daria Shafranskaya, Luisella Righi, Angela Listì, Domenico Vitale, Antonino Iaccarino, Umberto Malapelle, and Giancarlo Troncone

Subjects
Lung, Molecular pathology, Tumor biomarker, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Introduction Biomarker testing is mandatory for the clinical management of patients with advanced non-small cell lung cancer (NSCLC). Myriads of technical platforms are now available for biomarker analysis with differences in terms of multiplexing capability, analytical sensitivity, and turnaround time (TAT). We evaluated the technical performance of the diagnostic workflows of 24 representative Italian institutions performing molecular tests on a series of artificial reference specimens built to mimic routine diagnostic samples. Methods Sample sets of eight slides from cell blocks of artificial reference specimens harboring exon 19 EGFR (epidermal growth factor receptor) p.E746_AT50del, exon 2 KRAS (Kirsten rat sarcoma viral oncogene homologue) p.G12C, ROS1 (c-ros oncogene 1)-unknown gene fusion, and MET (MET proto-oncogene, receptor tyrosine kinase) Δ exon 14 skipping were distributed to each participating institution. Two independent cell block specimens were validated by the University of Naples Federico II before shipment. Methodological and molecular data from reference specimens were annotated. Results Overall, a median DNA concentration of 3.3 ng/µL (range 0.1–10.0 ng/µL) and 13.4 ng/µL (range 2.0–45.8 ng/µL) were obtained with automated and manual technical procedures, respectively. RNA concentrations of 5.7 ng/µL (range 0.2–11.9 ng/µL) and 9.3 ng/µL (range 0.5–18.0 ng/µL) were also detected. KRAS exon 2 p.G12C, EGFR exon 19 p.E736_A750del hotspot mutations, and ROS1 aberrant transcripts were identified in all tested cases, whereas 15 out of 16 (93.7%) centers detected MET exon 14 skipping mutation. Conclusions Optimized technical workflows are crucial in the decision-making strategy of patients with NSCLC. Artificial reference specimens enable optimization of diagnostic workflows for predictive molecular analysis in routine clinical practice.

Published
2024
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8. A SAT Encoding to Compute Aperiodic Tiling Rhythmic Canons

Author

Auricchio, Gennaro, Ferrarini, Luca, Gualandi, Stefano, Lanzarotto, Greta, and Pernazza, Ludovico

Subjects
Mathematics - Optimization and Control, 03G05 90C09 05E99
Abstract

In Mathematical Music theory, the Aperiodic Tiling Complements Problem consists in finding all the possible aperiodic complements of a given rhythm $A$. The complexity of this problem depends on the size of the period $n$ of the canon and on the cardinality of the given rhythm $A$. The current state-of-the-art algorithms can solve instances with $n$ smaller than $180$. In this paper we propose an ILP formulation and a SAT Encoding to solve this mathemusical problem, and we use the Maplesat solver to enumerate all the aperiodic complements. We validate our SAT Encoding using several different periods and rhythms and we compute for the first time the complete list of aperiodic tiling complements of standard Vuza rhythms for canons of period $n=\{180,420,900\}$.

Published
2021

12. Open vs robotic gastrectomy with D2 lymphadenectomy: a propensity score-matched analysis on 1469 patients from the IMIGASTRIC prospective database

Author

Trastulli, Stefano, Desiderio, Jacopo, Lin, Jian-Xian, Reim, Daniel, Zheng, Chao-Hui, Borghi, Felice, Cianchi, Fabio, Norero, Enrique, Nguyen, Ninh T., Qi, Feng, Coratti, Andrea, Cesari, Maurizio, Bazzocchi, Francesca, Alimoglu, Orhan, Brower, Steven T., Pernazza, Graziano, D’Imporzano, Simone, Azagra, Juan-Santiago, Zhou, Yan-Bing, Cao, Shou-Gen, Guerra, Francesco, Liu, Tong, Arcuri, Giacomo, González, Paulina, Staderini, Fabio, Marano, Alessandra, Di Nardo, Domenico, Parisi, Amilcare, Huang, Chang-Ming, and Tebala, Giovanni Domenico

Published
2023
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15. High-grade serous carcinoma of unknown primary origin associated with STIC clinically presented as isolated inguinal lymphadenopathy: a case report

Author

Paola Giancontieri, Camilla Turetta, Giacomo Barchiesi, Angelina Pernazza, Gemma Pignataro, Giuliano D’Onghia, Daniele Santini, and Federica Tomao

Subjects
STIC, HGSOC, ovarian, cancer, lymphadenopathy, metastasis, p53, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Serous tubal intraepithelial carcinoma (STIC) is a precancerous lesion of high-grade serous ovarian carcinoma (HGSOC). Usually, it arises from the fimbrial end of the tube, and it is associated with metastatic potential. On average, the time to progress from STIC to HGSOC is 6.5 years. Therefore, whenever a STIC lesion is found, surgical staging and prophylactic salpingectomy are recommended in order to prevent ovarian cancer. We report a rare case of a 45-year-old female patient who clinically presented an isolated right inguinal lymphadenopathy. The remaining clinical examination was normal. Therefore, an excisional biopsy of the lymph node was performed. Pathological analysis revealed a high-grade serous carcinoma, most likely of gynecological origin. Due to histological evidence, a computed tomography (CT) scan was carried out. There was no CT evidence of ovarian disease, pelvic involvement, intra-abdominal lymphadenopathies, metastatic disease, or ascites. All tumor markers were negative. The patient underwent laparoscopic hysterectomy and bilateral salpingo-oophorectomy followed by surgical staging. Surprisingly, pathological examination showed a STIC lesion in the fimbria of the left fallopian tube. We aim to report the potential capability of STIC to spread particularly through lymphatic pathways rather than peritoneal dissemination.

Published
2024
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17. 'Cheerios in the lung' as first metastases from endometrial endometrioid adenocarcinoma with adequate response to immunotherapy

Author

Chiara De Nardo, Nicholas Landini, Michele Massaro, Angelina Pernazza, Francesca Arienzo, Marco Bicchetti, Valeria Panebianco, and Carlo Catalano

Subjects
Lung metastases, Endometrial endometrioid adenocarcinoma, Immunotherapy, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Abstract Background Metastases from endometrial carcinoma to the lungs are uncommon and cavitating metastases are even rarer. In some cases, lung cavitating metastases may resemble diffuse “Cheerios in the lung.” Case presentation A 58-year-old woman, smoker, with a history of hysteroannessiectomy and pelvic lymphadenectomy for a low stage endometrial endometrioid adenocarcinoma, came under our attention for dry cough without fever that persisted for over three months, and computed tomography (CT) revealed diffuse cavitating lung metastases resembling "Cheerios in the lung". After standard chemotherapy proved ineffective, Lenvatinib plus Pembrolizumab (immunotherapy) was administrated, leading to the disappearance of all lung nodules, leaving behind a diffuse emphysematous-like pattern. Conclusions This case is a rare example of metastatic endometrioid adenocarcinoma, manifested with chronic dry cough, with “Cheerios in the lung” appearence. The metastases responded well to immunotherapy, resulting in the regression of nodules into areas of diffuse emphysematous-like changes.

Published
2023
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18. Surgeon experience influence lymphadenectomy during VATS lobectomy: National VATS database results

Author

Maurizio, Mancuso, Fausto, Pernazza, Majed, Refai, Franco, Stella, Desideria, Argnani, Giuseppe, Marulli, Angela, De Palma, Luigi, Bortolotti, Giovanna, Rizzardi, Piergiorgio, Solli, Giampiero, Dolci, Reinhold, Perkmann, Francesco, Zaraca, Roberto, Benvenuti Mauro, Diego, Gavezzoli, Roberto, Cherchi, Albino, Ferrari Paolo, Felice, Mucilli, Pierpaolo, Camplese, Giulio, Melloni, Federico, Mazza, Giorgio, Cavallesco, Pio, Maniscalco, Luca, Voltolini, Alessandro, Gonfiotti, Francesco, Sollitto, Pia, Ardò Nicoletta, Luca, Pariscenti Gian, Carlo, Risso, Corrado, Surrente, Camillo, Lopez, Andrea, Droghetti, Michele, Giovanardi, Cristiano, Breda, Fabio, Lo Giudice, Marco, Alloisio, Edoardo, Bottoni, Lorenzo, Spaggiari, Roberto, Gasparri, Massimo, Torre, Alessandro, Rinaldo, Mario, Nosotti, Davide, Tosi, Giampeiro, Negri, Alessandro, Bandiera, Alessandro, Baisi, Federico, Raveglia, Alessandro, Stefani, Pamela, Natali, Marco, Scarci, Emanuele, Pirondini, Carlo, Curcio, Dario, Amore, Ottavio, Rena, Samuele, Nicotra, Andrea, Dell' Amore, Alessandro, Bertani, Giorgia, Tancredi, Luca, Ampollini, Paolo, Carbognani, Francesco, Puma, Damiano, Vinci, Giuseppe, Cardillo, Francesco, Carleo, Nachira, Dania, Piero, Paladini, Marco, Ghisalberti, Roberto, Crisci, Duilio, Divisi, Diego, Fontana, Vittorio, Della Beffa, Angelo, Morelli, Francesco, Londero, Andrea, Imperatori, Nicola, Rotolo, Alberto, Andrea, Viti, Maurizio, Infante, Cristiano, Benato, Chiappetta, Marco, Sassorossi, Carolina, Lococo, Filippo, Curcio, Carlo, Crisci, Roberto, Sperduti, Isabella, Meacci, Elisa, and Margaritora, Stefano

Published
2024
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20. Laparoscopic Compared with Open D2 Gastrectomy on Perioperative and Long-Term, Stage-Stratified Oncological Outcomes for Gastric Cancer: A Propensity Score-Matched Analysis of the IMIGASTRIC Database.

Author

Trastulli, Stefano, Desiderio, Jacopo, Lin, Jian-Xian, Reim, Daniel, Zheng, Chao-Hui, Borghi, Felice, Cianchi, Fabio, Norero, Enrique, Nguyen, Ninh T, Qi, Feng, Coratti, Andrea, Cesari, Maurizio, Bazzocchi, Francesca, Alimoglu, Orhan, Brower, Steven T, Pernazza, Graziano, D'Imporzano, Simone, Azagra, Juan-Santiago, Zhou, Yan-Bing, Cao, Shou-Gen, Garofoli, Eleonora, Mosillo, Claudia, Guerra, Francesco, Liu, Tong, Arcuri, Giacomo, González, Paulina, Staderini, Fabio, Marano, Alessandra, Terrenato, Irene, D'Andrea, Vito, Bracarda, Sergio, Huang, Chang-Ming, and Parisi, Amilcare

Subjects
gastric cancer, laparoscopy, minimally invasive surgery, Clinical Research, Patient Safety, Cancer, 6.4 Surgery, Oncology and Carcinogenesis
Abstract

BackgroundThe laparoscopic approach in gastric cancer surgery is being increasingly adopted worldwide. However, studies focusing specifically on laparoscopic gastrectomy with D2 lymphadenectomy are still lacking in the literature. This retrospective study aimed to compare the short-term and long-term outcomes of laparoscopic versus open gastrectomy with D2 lymphadenectomy for gastric cancer.MethodsThe protocol-based, international IMIGASTRIC (International study group on Minimally Invasive surgery for Gastric Cancer) registry was queried to retrieve data on patients undergoing laparoscopic or open gastrectomy with D2 lymphadenectomy for gastric cancer with curative intent from January 2000 to December 2014. Eleven predefined, demographical, clinical, and pathological variables were used to conduct a 1:1 propensity score matching (PSM) analysis to investigate intraoperative and recovery outcomes, complications, pathological findings, and survival data between the two groups. Predictive factors of long-term survival were also assessed.ResultsA total of 3033 patients from 14 participating institutions were selected from the IMIGASTRIC database. After 1:1 PSM, a total of 1248 patients, 624 in the laparoscopic group and 624 in the open group, were matched and included in the final analysis. The total operative time (median 180 versus 240 min, p < 0.0001) and the length of the postoperative hospital stay (median 10 versus 14.8 days, p < 0.0001) were longer in the open group than in the laparoscopic group. The conversion to open rate was 1.9%. The proportion of patients with in-hospital complications was higher in the open group (21.3% versus 15.1%, p = 0.004). The median number of harvested lymph nodes was higher in the laparoscopic approach (median 32 versus 28, p < 0.0001), and the proportion of positive resection margins was higher (p = 0.021) in the open group (5.9%) than in the laparoscopic group (3.2%). There was no significant difference between the groups in five-year overall survival rates (77.4% laparoscopic versus 75.2% open, p = 0.229).ConclusionThe adoption of the laparoscopic approach for gastric resection with D2 lymphadenectomy shortened the length of hospital stay and reduced postoperative complications with respect to the open approach. The five-year overall survival rate after laparoscopy was comparable to that for patients who underwent open D2 resection. The types of surgical approaches are not independent predictive factors for five-year overall survival.

Published
2021

21. Xanthoma of rib: a case report and review of the literature

Author

Emilia Mottola, Flavia Adotti, Angelina Pernazza, Carlo Della Rocca, Giulia D’Amati, Piergiorgio Nardis, Jacopo Vannucci, Massimiliano Bassi, Federico Venuta, and Marco Anile

Subjects
Xanthoma, Rib, Hyperlipidemia, Thoracic trauma, Surgery, RD1-811, Anesthesiology, RD78.3-87.3
Abstract

Abstract Background Xanthomas are well-circumscribed benign proliferative lesions seen mainly in soft tissues. Usually, they are found in hyperlipidemia and familial hyperlipoproteinemia. Histologically, are characterized by macrophage-like mononuclear cells, multinucleated giant cells and abundant foam cells. The bone involvement, however, is notoriously rare and rib localization is extremely rare. Case presentation A 55-year-old man performed a chest X-ray and a subsequent chest Computed Tomography scan showing a rib lesion that was surgically removed and a diagnosis of rib xanthoma was made. The patient presented an unknown condition of hyperlipidemia. Conclusion Rib xanthoma can be discovered accidentally and can be helpful in identifying an unrecognized condition of hyperlipidemia.

Published
2023
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22. Therapeutic Strategies and Oncological Outcome of Peritoneal Metastases from Lung Cancer: A Systematic Review and Pooled Analysis

Author

Leandro Siragusa, Sara Di Carlo, Alessia Fassari, Bruno Sensi, Camilla Riccetti, Luciano Izzo, Giuseppe Cavallaro, Enrico Fiori, Paolo Sapienza, Letizia Mallia, Graziano Pernazza, and Simone Sibio

Subjects
lung cancer, peritoneal metastases, peritoneal carcinomatosis, palliative chemotherapy, cytoreductive surgery, HIPEC, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

The peritoneum is an unusual site of metastases from lung cancer, and optimal management at the moment remains unclear and mostly based on palliative strategies. Therefore, the aim of the study was to investigate demographic characteristics, management and overall survival of patients with peritoneal metastases from lung cancer (PCLC). A PRISMA-compliant systematic review and pooled analysis was performed searching all English studies published until December 2022. PROSPERO, CRD42022349362. Inclusion criteria were original articles including patients with peritoneal carcinomatosis from lung cancer, specifying at least one outcome of interest. Exclusion criteria were being unable to retrieve patient data from articles, and the same patient series included in different studies. Among 1746 studies imported for screening, twenty-one were included (2783 patients). Mean overall survival was between 0.5 and 5 months after peritoneal carcinomatosis diagnosis and 9 and 21 months from lung cancer diagnosis. In total, 27% of patients underwent first-line or palliative chemotherapy and 7% of them surgery. Management differs significantly among published studies. The literature on PCLC is scarce. Its incidence is low but appears to be substantially rising and is likely to be an underestimation. Prognosis is very poor and therapeutic strategies have been limited and used in a minority of patients. Subcategories of PCLC patients may have an improved prognosis and may benefit from an aggressive oncological approach, including cytoreductive surgery. Further investigation would be needed in this regard.

Published
2023
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23. Advancing the PD-L1 CPS test in metastatic TNBC: Insights from pathologists and findings from a nationwide survey

Author

Fusco, Nicola, Ivanova, Mariia, Frascarelli, Chiara, Criscitiello, Carmen, Cerbelli, Bruna, Pignataro, Maria Gemma, Pernazza, Angelina, Sajjadi, Elham, Venetis, Konstantinos, Cursano, Giulia, Pagni, Fabio, Di Bella, Camillo, Accardo, Marina, Amato, Michelina, Amico, Paolo, Bartoli, Caterina, Bogina, Giuseppe, Bortesi, Laura, Boldorini, Renzo, Bruno, Sara, Cabibi, Daniela, Caruana, Pietro, Dainese, Emanuele, De Camilli, Elisa, Dell’Anna, Vladimiro, Duda, Loren, Emmanuele, Carmela, Fanelli, Giuseppe Nicolò, Fernandes, Bethania, Ferrara, Gerardo, Gnetti, Letizia, Gurrera, Alessandra, Leone, Giorgia, Lucci, Raffaella, Mancini, Cristina, Marangi, Grazia, Mastropasqua, Mauro G., Nibid, Lorenzo, Orrù, Sandra, Pastena, Maria, Peresi, Monica, Perracchio, Letizia, Santoro, Angela, Vezzosi, Vania, Zambelli, Claudia, Zuccalà, Valeria, Rizzo, Antonio, Costarelli, Leopoldo, Pietribiasi, Francesca, Santinelli, Alfredo, Scatena, Cristian, Curigliano, Giuseppe, Guerini-Rocco, Elena, Martini, Maurizio, Graziano, Paolo, Castellano, Isabella, and d'Amati, Giulia

Published
2023
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24. Enhanced recovery after surgery (ERAS) program in octogenarian patients: a propensity score matching analysis on the “Lazio Network” database

Author

Grieco, Michele, Galiffa, Giampaolo, Lorenzon, Laura, Marincola, Giuseppe, Persiani, Roberto, Santoro, Roberto, Pernazza, Graziano, Brescia, Antonio, Santoro, Emanuele, Stipa, Francesco, Crucitti, Antonio, Mancini, Stefano, Palmieri, Raffaele Macarone, Di Paola, Massimiliano, Sacchi, Marco, and Carlini, Massimo

Published
2022
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27. A SAT Encoding to Compute Aperiodic Tiling Rhythmic Canons

Author

Auricchio, Gennaro, Ferrarini, Luca, Gualandi, Stefano, Lanzarotto, Greta, Pernazza, Ludovico, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, and Schaus, Pierre, editor

Published
2022
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28. Extended Vuza Canons

Author

Lanzarotto, Greta, Pernazza, Ludovico, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Montiel, Mariana, editor, Agustín-Aquino, Octavio A., editor, Gómez, Francisco, editor, Kastine, Jeremy, editor, Lluis-Puebla, Emilio, editor, and Milam, Brent, editor

Published
2022
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29. The Overweight Paradox: Impact of Body Mass Index on Patients Undergoing VATS Lobectomy or Segmentectomy

Author

Parini, Sara, Azzolina, Danila, Massera, Fabio, Mastromarino, Maria Giovanna, Papalia, Esther, Baietto, Guido, Curcio, Carlo, Crisci, Roberto, Rena, Ottavio, Alloisio, Marco, Amore, Dario, Ampollini, Luca, Ardò, Nicoletta, Argnani, Desideria, Baisi, Alessandro, Bandiera, Alessandro, Benato, Cristiano, Benvenuti, Mauro Roberto, Bertani, Alessandro, Bortolotti, Luigi, Bottoni, Edoardo, Breda, Cristiano, Camplese, Pierpaolo, Carbognani, Paolo, Cardillo, Giuseppe, Carleo, Francesco, Cavallesco, Giorgio, Cherchi, Roberto, De Palma, Angela, Dell'Amore, Andrea, Della Beffa, Vittorio, Divisi, Duilio, Dolci, Giampiero, Droghetti, Andrea, Ferrari, Paolo, Fontana, Diego, Gasparri, Roberto, Gavezzoli, Diego, Ghisalberti, Marco, Giovanardi, Michele, Gonfiotti, Alessandro, Guerrera, Francesco, Imperatori, Andrea, Infante, Maurizio, Lausi, Paolo, Lo Giudice, Fabio, Londero, Francesco, Lopez, Camillo, Mancuso, Maurizio, Maniscalco, Pio, Margaritora, Stefano, Marulli, Giuseppe, Mazza, Federico, Meacci, Elisa, Melloni, Giulio, Morelli, Angelo, Mucilli, Felice, Natali, Pamela, Negri, Giampiero, Nicotra, Samuele, Nosotti, Mario, Paladini, Piero, Pariscenti, Gianluca, Perkmann, Reinhold, Pernazza, Fausto, Pirondini, Emanuele, Puma, Francesco, Raveglia, Federico, Refai, Majed, Rinaldo, Alessandro, Risso, Carlo, Rizzardi, Giovanna, Rotolo, Nicola, Scarci, Marco, Solli, Piergiorgio, Sollitto, Francesco, Spaggiari, Lorenzo, Stefani, Alessandro, Stella, Franco, Surrente, Corrado, Tancredi, Giorgia, Terzi, Alberto, Torre, Massimo, Tosi, Davide, Vinci, Damiano, Viti, Andrea, Voltolini, Luca, and Zaraca, Francesco

Published
2023
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30. The contribution of the 1H-MRS lipid signal to cervical cancer prognosis: a preliminary study

Author

Miriam Dolciami, Rossella Canese, Claudia Testa, Angelina Pernazza, Giusi Santangelo, Innocenza Palaia, Carlo Della Rocca, Carlo Catalano, and Lucia Manganaro

Subjects
Choline, Lipids, Magnetic resonance imaging, Proton magnetic resonance spectroscopy, Uterine cervical neoplasms, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Abstract Background The aim of this study was to investigate the role of the lipid peak derived from 1H magnetic resonance (MR) spectroscopy in assessing cervical cancer prognosis, particularly in assessing response to neoadjuvant chemotherapy (NACT) of locally advanced cervical cancer (LACC). Methods We enrolled 17 patients with histologically proven cervical cancer who underwent 3-T MR imaging at baseline. In addition to conventional imaging sequences for pelvic assessment, the protocol included a single-voxel point-resolved spectroscopy (PRESS) sequence, with repetition time of 1,500 ms and echo times of 28 and 144 ms. Spectra were analysed using the LCModel fitting routine, thus extracting multiple metabolites, including lipids (Lip) and total choline (tCho). Patients with LACC were treated with NACT and reassessed by MRI at term. Based on tumour volume reduction, patients were classified as good responder (GR; tumour volume reduction > 50%) and poor responder or nonresponder (PR-or-NR; tumour volume reduction ≤ 50%). Results Of 17 patients, 11 were LACC. Of these 11, only 6 had both completed NACT and had good-quality 1H-MR spectra; 3 GR and 3 PR-or-NR. A significant difference in lipid values was observed in the two groups of patients, particularly with higher Lip values and higher Lip/tCho ratio in PR-NR patients (p =0.040). A significant difference was also observed in choline distribution (tCho), with higher values in GR patients (p = 0.040). Conclusions Assessment of lipid peak at 1H-MR spectroscopy could be an additional quantitative parameter in predicting the response to NACT in patients with LACC.

Published
2022
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31. Laterocervical lymph node metastases from suspected thyroidal primary site that turned out to be metastases of lung cancer: A case report

Author

Chiara Scorziello, Maria Carola Borcea, Marco Biffoni, Angelina Pernazza, Francesca Arienzo, Rossella Melcarne, Luca Ventrone, Angelo Laca, Giorgio Grani, Cosimo Durante, Fabrizio Consorti, and Laura Giacomelli

Subjects
case report, lung adenocarcinoma, lung cancer, non‐thyroidal cervical lymph node metastases, thyroid cancer, Medicine, Medicine (General), R5-920
Abstract

Key Clinical Message Incidental sonographic discovery of thyroid nodules is an increasingly common event in clinical practice. Less frequently, patients with cytological benign thyroid nodules have suspicious cervical lymph nodes detected by ultrasound examination or by cytological exam. Here, we discuss an intriguing case of cervical lymph node metastasis with a probable thyroid origin in a 65‐year‐old asymptomatic male smoker. He underwent thyroidectomy and unilateral cervical lymphadenectomy. Despite a negative chest X‐ray, the postoperative histological examination revealed that the lymph node metastasis was actually from a lung carcinoma. Metastatic lesions in cervical lymph nodes from non‐thyroidal origins must be excluded when evaluating lesions in the region, especially when thyroid nodules subjected to fine needle aspiration biopsy yield negative results, or lymph node cytological evaluations are inconsistent with thyroid cytological findings and sonographic features. Thyroid and lung adenocarcinomas share some epithelial and mesenchymal markers. Thyroglobulin helps differentiate primary thyroid tumors from lung ones, but in cases of poor differentiation, distinguishing metastatic lesions in the thyroid gland can be challenging. Lung cancer (LC) is the leading cause of cancer mortality worldwide, and survival rates have only marginally improved over the last several decades. The ongoing clinical challenge is detecting LC at earlier stages of the disease.

Published
2023
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37. Not all that glitters is gold

Author

Anile, Marco, primary, Ferrante, Francesco, additional, Zacchini, Beatrice, additional, Pernazza, Angelina, additional, Bassi, Massimiliano, additional, Vannucci, Jacopo, additional, and Venuta, Federico, additional

Published
2024
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38. Vulvar lipoma: rare case, rare location

Author

Cuccu, I., primary, Golia D’Augè, T., additional, Di Dio, C., additional, Giannini, A., additional, Laganà, A.S., additional, Chiantera, V., additional, Bogani, G., additional, Pernazza, A., additional, Manganaro, L., additional, Miceli, V., additional, Santangelo, G., additional, Muzii, L., additional, Di Donato, V., additional, and Perniola, G., additional

Published
2024
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40. Post-operative outcomes and quality of life assessment after thoracoscopic lobectomy for Non-small-cell lung cancer in octogenarians: Analysis from a national database

Author

Alloisio, Marco, Amore, Dario, Ampollini, Luca, Andreetti, Claudio, Argnani, Desideria, Baietto, Guido, Bandiera, Alessandro, Benato, Cristiano, Benvenuti, Mauro Roberto, Bertani, Alessandro, Bertolaccini, Luca, Bortolotti, Luigi, Bottoni, Edoardo, Breda, Cristiano, Camplese, Pierpaolo, Carbognani, Paolo, Cardillo, Giuseppe, Casadio, Caterina, Cavallesco, Giorgio, Cherchi, Roberto, Crisci, Roberto, Curcio, Carlo, Dell’Amore, Andrea, Della Beffa, Vittorio, Dolci, Giampiero, Droghetti, Andrea, Ferrari, Paolo A., Fontana, Diego, Gargiulo, Gaetano, Gasparri, Roberto, Gavezzoli, Diego, Ghisalberti, Marco, Giovanardi, Michele, Gonfiotti, Alessandro, Guerrera, Francesco, Imperatori, Andrea, Infante, Maurizio, Iurilli, Luciano, Lausi, Paolo, Lo Giudice, Fabio, Londero, Francesco, Luzzi, Luca, Lopez, Camillo, Mancuso, Maurizio, Maniscalco, Pio, Margaritora, Stefano, Meacci, Elisa, Melloni, Giulio, Morelli, Angelo, Mucilli, Felice, Natali, Pamela, Negri, Giampiero, Nicotra, Samuele, Nosotti, Mario, Pariscenti, Gianluca, Perkmann, Reinhold, Pernazza, Fausto, Pirondini, Emanuele, Poggi, Camilla, Puma, Francesco, Refai, Majed, Rinaldo, Alessandro, Rizzardi, Giovanna, Rosso, Lorenzo, Rotolo, Nicola, Russo, Emanuele, Sabbatini, Armando, Scarci, Marco, Spaggiari, Lorenzo, Stefani, Alessandro, Solli, Piergiorgio, Surrente, Corrado, Terzi, Alberto, Torre, Massimo, Vinci, Damiano, Viti, Andrea, Voltolini, Luca, Zaccagna, Gino, Zaraca, Francesco, Bongiolatti, Stefano, and Borgianni, Sara

Published
2021
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44. Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery.

Author

Parisi, Amilcare, Reim, Daniel, Borghi, Felice, Nguyen, Ninh T, Qi, Feng, Coratti, Andrea, Cianchi, Fabio, Cesari, Maurizio, Bazzocchi, Francesca, Alimoglu, Orhan, Gagnière, Johan, Pernazza, Graziano, D'Imporzano, Simone, Zhou, Yan-Bing, Azagra, Juan-Santiago, Facy, Olivier, Brower, Steven T, Jiang, Zhi-Wei, Zang, Lu, Isik, Arda, Gemini, Alessandro, Trastulli, Stefano, Novotny, Alexander, Marano, Alessandra, Liu, Tong, Annecchiarico, Mario, Badii, Benedetta, Arcuri, Giacomo, Avanzolini, Andrea, Leblebici, Metin, Pezet, Denis, Cao, Shou-Gen, Goergen, Martine, Zhang, Shu, Palazzini, Giorgio, D'Andrea, Vito, and Desiderio, Jacopo

Subjects
Humans, Stomach Neoplasms, Postoperative Complications, Laparoscopy, Retrospective Studies, Aged, Aged, 80 and over, Middle Aged, Italy, Female, Male, Robotic Surgical Procedures, Gastrectomy, Gastric cancer, Minimally invasive surgery, Robot-assisted, Robotic, and over, Gastroenterology & Hepatology, Clinical Sciences
Abstract

AimTo investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.MethodsThis is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy (RG), laparoscopic gastrectomy (LG), open gastrectomy (OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.ResultsThe present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients (RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery (P = 0.42) and stage of the disease (P = 0.16). Intraoperative blood loss was significantly lower in the LG (95.93 ± 119.22) and RG (117.91 ± 68.11) groups compared to the OG (127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG (27.78 ± 11.45), LG (24.58 ± 13.56) and OG (25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay (P < 0.0001). A similar complications rate was found (P = 0.13). The leakage rate was not different (P = 0.78) between groups.ConclusionLaparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery.

Published
2017

45. Predicting a Prolonged Air Leak After Video-Assisted Thoracic Surgery, Is It Really Possible?

Author

Mancuso, M., Pernazza, F., Refai, M., Srella, F., Argnani, D., Marulli, G., De Palma, A., Bortolotti, L., Rizzardi, G., Solli, P.G., Dolci, G.P., Perkmann, R., Zaraca, F., Benvenuti, M., Gavezzoli, D., Cherchi, R., Ferrari, P., Mucilli, F., Camplese, P., Melloni, G., Mazza, F., Cavallesco, G., Maniscalco, P., Voltolini, L., Gonfiotti, A., Sollitto, F., Ardò, N., Pariscenti, G.L., Risso, C., Surrente, C., Lopez, C., Droghetti, A., Giovanardi, M., Breda, C., Giudice, Lo F., Alloisio, M., Bottoni, E., Spaggiari, L., Gasparri, R., Torre, M., Rinaldo, A., Nosotti, M., Tosi, D., Negri, G.P., Bandiera, A., Baisi, A., Raveglia, F., Stefani, A., Natali, P., Scarci, M., Pirondini, E., Curcio, C., Amore, D., Rena, O., Nicotra, S., Dell’ Amore, A., Bertani, A., Tancredi, G., Ampollini, L., Carbognani, P., Puma, F., Vinci, D., Cardillo, G., Carleo, F., Margaritora, S., Meacci, E., Luzzi, L., Ghisalberti, M., Crisci, R., Divisi, D., Lausi, P., Guerrera, F., Fontana, D., Beffa, V. Della, Morelli, A., Londero, F., Imperatori, A., Rotolo, N., Terzi, A., Viti, A., Infante, M., Benato, C., Zaraca, Francesco, Pipitone, Marco, Feil, Birgit, Perkmann, Reinhold, Bertolaccini, Luca, Curcio, Carlo, and Crisci, Roberto

Published
2021
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46. Circulating CD137+ T Cell Levels Are Correlated with Response to Pembrolizumab Treatment in Advanced Head and Neck Cancer Patients

Author

Alessio Cirillo, Ilaria Grazia Zizzari, Andrea Botticelli, Lidia Strigari, Hassan Rahimi, Simone Scagnoli, Fabio Scirocchi, Angelina Pernazza, Angelica Pace, Bruna Cerbelli, Giulia d’Amati, Paolo Marchetti, Marianna Nuti, Aurelia Rughetti, and Chiara Napoletano

Subjects
immunotherapy, anti-PD1, HNSCC, CD137, 4-1BB, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Pembrolizumab, an anti-PD-1 antibody, has been approved as first-line treatment for recurrent or metastatic head and neck squamous cell carcinoma ((R/M) HNSCC). However, only a minority of patients benefit from immunotherapy, which highlights the need to identify novel biomarkers to optimize treatment strategies. CD137+ T cells have been identified as tumour-specific T cells correlated with immunotherapy responses in several solid tumours. In this study, we investigated the role of circulating CD137+ T cells in (R/M) HNSCC patients undergoing pembrolizumab treatment. PBMCs obtained from 40 (R/M) HNSCC patients with a PD-L1 combined positive score (CPS) ≥1 were analysed at baseline via cytofluorimetry for the expression of CD137, and it was found that the percentage of CD3+CD137+ cells is correlated with the clinical benefit rate (CBR), PFS, and OS. The results show that levels of circulating CD137+ T cells are significantly higher in responder patients than in non-responders (p = 0.03). Moreover, patients with CD3+CD137+ percentage ≥1.65% had prolonged OS (p = 0.02) and PFS (p = 0.02). Multivariate analysis, on a combination of biological and clinical parameters, showed that high levels of CD3+CD137+ cells (≥1.65%) and performance status (PS) = 0 are independent prognostic factors of PFS (CD137+ T cells, p = 0.007; PS, p = 0.002) and OS (CD137+ T cells, p = 0.006; PS, p = 0.001). Our results suggest that levels of circulating CD137+ T cells could serve as biomarkers for predicting the response of (R/M) HNSCC patients to pembrolizumab treatment, thus contributing to the success of anti-cancer treatment.

Published
2023
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48. Robotic versus laparoscopic distal pancreatectomy for pancreatic adenocarcinoma in obese patients

Author

Ausania, Fabio, primary, Landi, Filippo, additional, González‐Abós, Carolina, additional, Martinie, John B., additional, Vrochides, Dionisios, additional, Walsh, Matthew, additional, Hossain, Shanaz M., additional, White, Steven, additional, Prabakaran, Viswakumar, additional, Melstrom, Laleh G., additional, Fong, Yuman, additional, Valle, Valentina, additional, Bing, Yuntao, additional, Xiu, Dianrong, additional, Di Franco, Gregorio, additional, de' Angelis, Nicola, additional, Laurent, Alexis, additional, Giuliani, Giuseppe, additional, Pernazza, Graziano, additional, Memeo, Riccardo, additional, Rios, José, additional, Coratti, Andrea, additional, Morelli, Luca, additional, and Giulianotti, Pier C., additional

Published
2023
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