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1. Thermoresponsive PNIPAM/FeRh smart composite activated by magnetic field for doxorubicin release

Author

Amirov, Abdulkarim A., Permyakova, Elizaveta S., Yusupov, Dibir M., Savintseva, Irina V., Murliev, Eldar K., Rabadanov, Kamil Sh., Popov, Anton L., Chirkova, Alisa M., and Aliev, Akhmed M.

Subjects
Condensed Matter - Materials Science
Abstract

The ability to control by physical properties of the thermoresponsive polymer of PNIPAM by magnetocaloric effect was demonstrated by in-situ experiments on PNIPAM/FeRh smart composite. The concept of drug release loaded in smart composite by applying of 3 T magnetic field was demonstrated using an example of doxorubicin. Released results of the magnetic field applying the drug were detected using IV-VIS and Raman spectroscopy. In vitro, studies have demonstrated a high degree of PNIPAM/FeRh scaffold biocompatibility for primary mouse embryonic fibroblasts (PMEF) cell culture. PMEFs effectively ad-hered to the PNIPAM/FeRh scaffold surface and showed high metabolic and proliferative activity for 72 h after seeding., Comment: 8 pages, 12 figures

Published
2024

7. Different concepts for creating antibacterial yet biocompatible surfaces: Adding bactericidal element, grafting therapeutic agent through COOH plasma polymer and their combination

Author

Permyakova, Elizaveta S., Manakhov, Anton M., Kiryukhantsev-Korneev, Philipp V., Sheveyko, Alexander N., Gudz, Kristina Y., Kovalskii, Andrey M., Polčak, Josef, Zhitnyak, Irina Y., Gloushankova, Natalia A., Dyatlov, Ivan A., Ignatov, Sergei G., Ershov, Sergey, and Shtansky, Dmitry V.

Published
2021
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9. Polycaprolactone Nanofibers Functionalized by Fibronectin/Gentamicin and Implanted Silver for Enhanced Antibacterial Properties, Cell Adhesion, and Proliferation

Author

Permyakova, Elizaveta S., primary, Solovieva, Anastasiya O., additional, Sitnikova, Natalia, additional, Kiryukhantsev-Korneev, Philipp V., additional, Kutzhanov, Magzhan K., additional, Sheveyko, Alexander N., additional, Ignatov, Sergey G., additional, Slukin, Pavel V., additional, Shtansky, Dmitry V., additional, and Manakhov, Anton M., additional

Published
2024
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16. X‑ray and UV Irradiation-Induced Reactive Oxygen Species Mediated Antibacterial Activity in Fe and Pt Nanoparticle-Decorated Si-Doped TiCaCON Films.

Author

Ponomarev, Viktor A., Sheveyko, Alexander N., Kuptsov, Konstantin A., Sukhanova, Ekaterina V., Popov, Zakhar I., Permyakova, Elizaveta S., Slukin, Pavel V., Ignatov, Sergei G., Ilnitskaya, Alla S., Gloushankova, Natalya A., Timoshenko, Roman V., Erofeev, Alexander S., Kuchmizhak, Aleksandr A., and Shtansky, Dmitry V.

Published
2023
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17. Study of Cytotoxicity and Internalization of Redox-Responsive Iron Oxide Nanoparticles on PC-3 and 4T1 Cancer Cell Lines

Author

Nizamov, Timur R., primary, Iliasov, Artem R., additional, Vodopyanov, Stepan S., additional, Kozhina, Irina V., additional, Bordyuzhin, Igor G., additional, Zhukov, Dmitry G., additional, Ivanova, Anna V., additional, Permyakova, Elizaveta S., additional, Mogilnikov, Pavel S., additional, Vishnevskiy, Daniil A., additional, Shchetinin, Igor V., additional, Abakumov, Maxim A., additional, and Savchenko, Alexander G., additional

Published
2022
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18. Antibacterial, UV-Protective, Hydrophobic, Washable, and Heat-Resistant BN-Based Nanoparticle-Coated Textile Fabrics: Experimental and Theoretical Insight

Author

Permyakova, Elizaveta S., primary, Tregubenko, Marya V., additional, Antipina, Liubov Yu., additional, Kovalskii, Andrey M., additional, Matveev, Andrei T., additional, Konopatsky, Anton S., additional, Manakhov, Anton M., additional, Slukin, Pavel V., additional, Ignatov, Sergei G., additional, and Shtansky, Dmitry V., additional

Published
2022
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24. Plasma‐coated PCL scaffolds with immobilized platelet‐rich plasma enhance the wound healing in diabetics mice

Author

Solovieva, Anastasiya O., primary, Permyakova, Elizaveta S., additional, Ershov, Konstantin I., additional, Bakhareva, Ksenia I., additional, Miroshnichenko, Svetlana M., additional, Kiryukhantsev‐Korneev, Philipp V., additional, Konopatsky, Anton S., additional, Polčak, Josef, additional, Shtansky, Dmitry V., additional, and Manakhov, Anton M., additional

Published
2022
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26. Biodegradable Nanohybrid Materials as Candidates for Self-Sanitizing Filters Aimed at Protection from SARS-CoV-2 in Public Areas

Author

Manakhov, Anton M., primary, Permyakova, Elizaveta S., additional, Sitnikova, Natalya A., additional, Tsygankova, Alphiya R., additional, Alekseev, Alexander Y., additional, Solomatina, Maria V., additional, Baidyshev, Victor S., additional, Popov, Zakhar I., additional, Blahová, Lucie, additional, Eliáš, Marek, additional, Zajíčková, Lenka, additional, Kovalskii, Andrey M., additional, Sheveyko, Alexander N., additional, Kiryukhantsev-Korneev, Philipp V., additional, Shtansky, Dmitry V., additional, Nečas, David, additional, and Solovieva, Anastasiya O., additional

Published
2022
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27. Microstructure and biological properties of titanium dioxide coatings doped with bioactive and bactericidal elements

Author

Ponomarev, Viktor A., primary, Popova, Anastasia D., additional, Sheveyko, Aleksander N., additional, Permyakova, Elizaveta S., additional, Kuptsov, Konstantin A., additional, Ilnitskaya, Alla S., additional, Slukin, Pavel V., additional, Ignatov, Sergei G., additional, Gloushankova, Natalia A., additional, Subramanian, B., additional, and Shtansky, Dmitry V., additional

Published
2022
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28. Study of Cytotoxicity and Internalization of Redox-Responsive Iron Oxide Nanoparticles on PC-3 and 4T1 Cancer Cell Lines.

Author

Nizamov, Timur R., Iliasov, Artem R., Vodopyanov, Stepan S., Kozhina, Irina V., Bordyuzhin, Igor G., Zhukov, Dmitry G., Ivanova, Anna V., Permyakova, Elizaveta S., Mogilnikov, Pavel S., Vishnevskiy, Daniil A., Shchetinin, Igor V., Abakumov, Maxim A., and Savchenko, Alexander G.

Subjects
IRON oxide nanoparticles, CANCER cells, CELL lines, IRON oxides, MAGNETIC cores, MAGNETIC nanoparticles, SURFACE grafting (Polymer chemistry), POLYETHYLENE glycol
Abstract

Redox-responsive and magnetic nanomaterials are widely used in tumor treatment separately, and while the application of their combined functionalities is perspective, exactly how such synergistic effects can be implemented is still unclear. This report investigates the internalization dynamics of magnetic redox-responsive nanoparticles (MNP-SS) and their cytotoxicity toward PC-3 and 4T1 cell lines. It is shown that MNP-SS synthesized by covalent grafting of polyethylene glycol (PEG) on the magnetic nanoparticle (MNP) surface via SS-bonds lose their colloidal stability and aggregate fully in a solution containing DTT, and partially in conditioned media, whereas the PEGylated MNP (MNP-PEG) without S-S linker control remains stable under the same conditions. Internalized MNP-SS lose the PEG shell more quickly, causing enhanced magnetic core dissolution and thus increased toxicity. This was confirmed by fluorescence microscopy using MNP-SS dual-labeled by Cy3 via labile disulfide, and Cy5 via a rigid linker. The dyes demonstrated a significant difference in fluorescence dynamics and intensity. Additionally, MNP-SS demonstrate quicker cellular uptake compared to MNP-PEG, as confirmed by TEM analysis. The combination of disulfide bonds, leading to faster dissolution of the iron oxide core, and the high-oxidative potential Fe3+ ions can synergically enhance oxidative stress in comparison with more stable coating without SS-bonds in the case of MNP-PEG. It decreases the cancer cell viability, especially for the 4T1, which is known for being sensitive to ferroptosis-triggering factors. In this work, we have shown the effect of redox-responsive grafting of the MNP surface as a key factor affecting MNP-internalization rate and dissolution with the release of iron ions inside cancer cells. This kind of synergistic effect is described for the first time and can be used not only in combination with drug delivery, but also in treatment of tumors responsive to ferroptosis. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens

Author

Gudz, Kristina Y., primary, Antipina, Liubov Yu., additional, Permyakova, Elizaveta S., additional, Kovalskii, Andrey M., additional, Konopatsky, Anton S., additional, Filippovich, Svetlana Yu., additional, Dyatlov, Ivan A., additional, Slukin, Pavel V., additional, Ignatov, Sergei G., additional, and Shtansky, Dmitry V., additional

Published
2021
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30. Pristine and antibiotic-loaded nanosheets/nanoneedles-based boron nitride films as a promising platform to suppress bacterial and fungal infections

Author

Gudz, Kristina Y., Permyakova, Elizaveta S., Matveev, Andrei T., Bondarev, Andrei, Manakhov, Anton M., Sidorenko, Daria, Filippovich, Svetlana, Brouchkov, Anatoli, Golberg, Dmitri, Ignatov, Sergei, Shtansky, Dmitry V., Gudz, Kristina Y., Permyakova, Elizaveta S., Matveev, Andrei T., Bondarev, Andrei, Manakhov, Anton M., Sidorenko, Daria, Filippovich, Svetlana, Brouchkov, Anatoli, Golberg, Dmitri, Ignatov, Sergei, and Shtansky, Dmitry V.

Abstract

In recent years, bacteria inactivation during their direct physical contact withsurface nanotopography has become one of the promising strategies for fighting infection. Contact-killing ability has been reported for several nanostructured surfaces, e.g. black silicon, carbon nanotubes, zinc oxide nanorods, and copper oxide nanosheets. Herein, we demonstrate that Gram-negative antibiotic-resistant Escherichia coli (E. coli) bacteria are killed as a result of their physical destruction while contacting nanostructured h-BN surfaces. BN films, made ofspherical nanoparticles formed by numerous nanosheets and nanoneedles with a thickness <15 nm, have been obtained through a reaction of ammonia with amorphous boron. The contact-killing bactericidal effect of BN nanostructures has been compared with a toxic effect of gentamicin released from them. For a wider protection against bacterial and fungal infection, the films have been saturated with a mixture of gentamicin and amphotericin B. Such BN films demonstrate a high antibiotic/antimycotic agent loading capacity and a fast initial and sustained release of therapeutic agents for 170-260 h depending on the loaded dose. The pristine BN films possess high antibacterial activity against E. coli K-261 strain at their initial concentration of 104 cells/mL,attaining >99 % inactivation of colony forming units after 24 h, same as gentamicin-loaded (150 µg/cm2) BN sample. The BN films loaded with a mixture of gentamicin (150 and 300 µg/cm2) and amphotericin B (100 µg/cm2) effectively inhibit the growth of E. coli K-261 and Neurospora crassa strains. During immersion in the normal saline solution, the BN film generates reactiveoxygen species (ROS), which can lead to accelerated oxidative stress at the site of physical cell damage. The obtained results are valuable for further development of nanostructured surfaces having contact killing, ROS and biocide release abilities.

Published
2020

31. New insights into synthesis of nanocrystalline hexagonal BN

Author

Matveev, Andrey T., Permyakova, Elizaveta S., Kovalskii, Andrey M., Leibo, Denis V., Shchetinin, Igor, Maslakov, Kirill, Golberg, Dmitri, Shtansky, Dmitry V., Konopatsky, Anton S., Matveev, Andrey T., Permyakova, Elizaveta S., Kovalskii, Andrey M., Leibo, Denis V., Shchetinin, Igor, Maslakov, Kirill, Golberg, Dmitri, Shtansky, Dmitry V., and Konopatsky, Anton S.

Abstract

Uncovering the mechanism behind nanocrystalline hexagonal boron nitride (h-BN) formation at relatively low temperatures is of great scientific and practical interest. Herein, the sequence of phase transformations occurring during the interaction of boric acid with ammonia in a temperature range of 25-1000 °C has been studied in detail by means of thermo-gravimetric analysis, X-ray diffraction, infrared spectroscopy, X-ray photoelectron spectroscopy, and high-resolution transmission electron microscopy. The results indicate that at room temperature boric acid reacts with ammonia to form an ammonium borate hydrate (NH4)2B4O7x4H2O. Its interaction with ammonia upon further heating at 550 °C for 1 h leads to the formation of turbostratic BN. Nanocrystalline h-BN is obtained either during heating in ammonia at 550 °C for 24 h or at 1000 °C for 1 h. This result is important for the development of novel cost-effective and scalable syntheses of h-BN nanostructures, such as nanosheets, nanoparticles, nanofibers, and nanofilms, as well as for sintering h-BN ceramic materials.

Published
2020

32. Polyol Synthesis of Ag/BN Nanohybrids and their Catalytic Stability in CO Oxidation Reaction

Author

Konopatsky, Anton S., Leybo, Denis V., Faershteyn, Konstantin, Chepkasov, Ilya, Popov, Zakhar I., Permyakova, Elizaveta S., Volkov, Ilia, Kovalskii, Andrey M., Matveev, Andrei T., Shtansky, Dmitry V., Golberg, Dmitri, Konopatsky, Anton S., Leybo, Denis V., Faershteyn, Konstantin, Chepkasov, Ilya, Popov, Zakhar I., Permyakova, Elizaveta S., Volkov, Ilia, Kovalskii, Andrey M., Matveev, Andrei T., Shtansky, Dmitry V., and Golberg, Dmitri

Abstract

Polyol method provides variety of options for microstructure control of a synthesized material. The present study aims to demonstrate that in case of Ag/h‐BN nanohybrid fabrication the synthesis time requires precise tuning. Nonlinear correlation between synthesis time and Ag nanoparticles (AgNPs) formation and deposition is found and discussed. Catalytic stability of the studied system toward carbon monoxide oxidation is investigated for the first time. Two stages of catalytic activity decrease are found and associated with the sintering of AgNPs of the certain size. Correlations between Ag content, particle size distribution and temperature of complete CO conversion allow us to conclude that AgNPs, which size is below the critical value (3 nm), have a decisive role in Ag/BN nanohybrid catalytic performance. Density functional theory (DFT) calculations uncover the mechanism behind the increased catalytic activity of smaller AgNPs and highlight an importance of the Ag/BN interfacial regions.

Published
2020

33. Reaction Sintering of Machinable TiB 2 -BN-C Ceramics with In-Situ Formed h-BN Nanostructure.

Author

Popov, Oleksii, Shtansky, Dmitry V., Vishnyakov, Vladimir, Klepko, Oleksandra, Polishchuk, Sergey, Kutzhanov, Magzhan K., Permyakova, Elizaveta S., and Teselko, Petro

Subjects
SIMPLE machines, CHEMICAL kinetics, CERAMICS, SINTERING, TITANIUM diboride, THERMAL shock, BORON nitride, HOT pressing
Abstract

Soft TiB2-BN-C hetero-modulus ceramics were sintered with the assistance of in-situ reactions during the hot pressing of TiN-B4C precursors. TiB2 formation was observed already after the hot pressing at 1100 °C, remaining the only phase identifiable by XRD even after sintering at 1500 °C. Analysis of reaction kinetics allows us to assume that the most probable reaction controlling stage is boron atoms sublimation and gas phase transfer from B4C to TiN. Reactive sintering route allows almost full densification of TiB2-BN-C composite ceramics at 1900 °C. The processes enable the formation of multilayer h-BN nanosheets inside the TiB2 matrix. The manufactured TiB2-33BN-13C ceramic with K1C = 5.3 MPa·m1/2 and HV = 1.6 GPa is extremely thermal shock-resistant at least up to quenching temperature differential of 800 °C. The sintered UHTC composite can be machined into complex geometry components. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Pristine and Antibiotic-Loaded Nanosheets/Nanoneedles-Based Boron Nitride Films as a Promising Platform to Suppress Bacterial and Fungal Infections

Author

Gudz, Kristina Y., primary, Permyakova, Elizaveta S., additional, Matveev, Andrei T., additional, Bondarev, Andrey V., additional, Manakhov, Anton M., additional, Sidorenko, Daria A., additional, Filippovich, Svetlana Y., additional, Brouchkov, Anatoli V., additional, Golberg, Dmitri V., additional, Ignatov, Sergei G., additional, and Shtansky, Dmitry V., additional

Published
2020
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35. Ag(Pt) nanoparticles-decorated bioactive yet antibacterial Ca- and P-doped TiO2 coatings produced by plasma electrolytic oxidation and ion implantation

Author

Ponomarev, Viktor A., primary, Orlov, Evgeny A., additional, Malikov, Nikolay A., additional, Tarasov, Yuriy V., additional, Sheveyko, Aleksander N., additional, Permyakova, Elizaveta S., additional, Kuptsov, Konstantin A., additional, Dyatlov, Ivan A., additional, Ignatov, Sergei G., additional, Ilnitskaya, Alla S., additional, Gloushankova, Natalia A., additional, Subramanian, B., additional, and Shtansky, Dmitry V., additional

Published
2020
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36. Polyol Synthesis of Ag/BN Nanohybrids and their Catalytic Stability in CO Oxidation Reaction

Author

Konopatsky, Anton S., primary, Leybo, Denis V., additional, Firestein, Konstantin L., additional, Chepkasov, Ilya V., additional, Popov, Zakhar I., additional, Permyakova, Elizaveta S., additional, Volkov, Ilia N., additional, Kovalskii, Andrey M., additional, Matveev, Andrei T., additional, Shtansky, Dmitry V., additional, and Golberg, Dmitri V., additional

Published
2020
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38. Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study

Author

Permyakova, Elizaveta S., primary, Antipina, Liubov Yu., additional, Kiryukhantsev-Korneev, Philipp V., additional, Kovalskii, Andrey M., additional, Polčak, Josef, additional, Manakhov, Anton, additional, Gudz, Kristina Yu., additional, Sorokin, Pavel B., additional, and Shtansky, Dmitry V., additional

Published
2019
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39. TiCaPCON-Supported Pt- and Fe-Based Nanoparticles and Related Antibacterial Activity

Author

Ponomarev, Viktor A., primary, Sheveyko, Aleksander N., additional, Permyakova, Elizaveta S., additional, Lee, Jihyung, additional, Voevodin, Andrey A., additional, Berman, Diana, additional, Manakhov, Anton M., additional, Michlíček, Miroslav, additional, Slukin, Pavel V., additional, Firstova, Viktoriya V., additional, Ignatov, Sergey G., additional, Chepkasov, Ilya V., additional, Popov, Zakhar I., additional, and Shtansky, Dmitry V., additional

Published
2019
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44. Synthesis and Characterization of Folate Conjugated Boron Nitride Nanocarriers for Targeted Drug Delivery

Author

Permyakova, Elizaveta S., Sukhorukova, Irina V., Antipina, Liubov Yu., Konopatsky, Anton S., Kovalskii, Andrey M., Matveev, Andrei T., Lebedev, Oleg I., Golberg, Dmitri V., Manakhov, Anton M., and Shtansky, Dmitry V.

Abstract

We have developed advanced folate bonded to boron nitride (BN) nanocarriers with a high potential for targeted drug delivery. The folic acid (FA) molecules were successfully conjugated to BN nanoparticles (BNNPs) in three consecutive stages: (i) FA preactivation by N,N′-dicyclohexylcarbodiimide (DCC), (ii) BNNP modification by AgNPs and their further NH2-functionalization with l-cysteine, and (iii) final conjugation of activated FA to modified BNNPs. To shed light on the FA-BNNPs binding mechanism, detailed energetic analysis of the atomic structure and stability of the FA-BNNPs system using density functional theory (DFT) calculations was carried out. The results indicated that the FA was successfully bonded with the BNNPs by a condensation reaction between amino groups of Cyst-Ag/BNNPs and carboxyl groups of FA using DCC. Theoretical analysis also demonstrated that the grafting of FA to the surface of BNNP does not affect FA targeting properties.

Published
2024
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